Noam Yarom, Tali Shani, Ninette Amariglio, Shlomo Taicher, Ilana Kaplan, Marilena Vered, Gidi Rechavi, L. Trakhtenbrot, Abraham Hirshberg,
The malignant potential of oral lichen planus (OLP) has been a matter of serious controversy. We aimed to detect chromosomal numerical aberrations in cells of brush samples collected from affected mucosa. The samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) with chromosomes 2 and 8 centromeric probes. We analyzed 57 persons with OLP and 33 control individuals. A cut-off value of aneuploid cells was determined as 1.1%. Aneuploid cells were found in 16 ...
Tópico(s): Oral and Maxillofacial Pathology
2009 - SAGE Publishing | Journal of Dental Research
Ilana Kaplan, Karen Anavi, Yakir Anavi, Shlomo Calderon, Dvora Schwartz-Arad, Shlomo Teicher, Avraham Hirshberg,
To characterize the clinical manifestations of Actinomyces-associated lesions of the oral mucosa and jawbones, and to correlate the clinical course and treatment requirements with the findings of histomorphometric analysis.The study was a 10-year retrospective analysis of archived cases with microscopic identification of Actinomyces infection. Actinomyces colonies were identified, using hematoxylin-eosin, Gram, and periodic acid-Schiff stains, exhibiting filamentous morphology with color variation ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2009 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Amir Shuster, Vadim Reiser, Luis Carlos Caporal Trejo, Clariel Ianculovici, Shlomi Kleinman, Ilana Kaplan,
The purpose of this study was to compare the histopathological parameters of chronic/suppurative osteomyelitis, medication-related osteonecrosis of the jaw (MRONJ), and osteoradionecrosis (ORN), and to examine the hypothesis that distinct histological features can be related to a specific disease, allowing for diagnosis based on microscopic evaluation alone. One hundred and ten samples were reviewed by two examiners in a blinded fashion, and a semi-quantitative histomorphometric analysis was performed. ...
Tópico(s): Bone and Joint Diseases
2018 - Elsevier BV | International Journal of Oral and Maxillofacial Surgery
Ilana Kaplan, Vadim Reiser, Amir Shuster, Benjamin Shlomi, Eli Rosenfeld, Adi Greenberg, Avraham Hirshberg, Ran Yahalom, Anna Shnaiderman-Shapiro, Marilena Vered,
To perform clinico-pathological characterization of a large series of oral metastases, collected from 3 main medical centers in Israel and compare findings to data on frequency of primary cancer types in the population.Pathology archives were searched for cases of metastatic tumors to the oral soft tissues and jawbones, 1990 - 2016. Metastases to the skin of face or to major salivary glands have been excluded. Demographic data and histopathological features were analyzed.Study population included ...
Tópico(s): Tumors and Oncological Cases
2019 - Elsevier BV | Acta Histochemica
Ormond S. Culp, Michelle Magid, Ilana Kaplan,
No AccessJournal of Urology1 Jun 1944Podophyllin Treatment of Condylomata Acuminata O.S. Culp, M.A. Magid, and I.W. Kaplan O.S. CulpO.S. Culp More articles by this author , M.A. MagidM.A. Magid More articles by this author , and I.W. KaplanI.W. Kaplan More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)70408-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1944 by The American Urological Association ...
Tópico(s): Fungal Infections and Studies
1944 - Lippincott Williams & Wilkins | The Journal of Urology
Tópico(s): Cervical Cancer and HPV Research
1944 - Lippincott Williams & Wilkins | Annals of Surgery
Orly Livny, Ram Reifen, Zecharia Madar, Betty Schwartz, Ilana Kaplan, Sylvie Polak‐Charcon,
Tópico(s): Biochemical Analysis and Sensing Techniques
2002 - Elsevier BV | Journal of Nutrition
Dror M. Allon, Ilana Kaplan, Ronen Manor, Shlomo Calderon,
Carcinoma cuniculatum is a rare variant of carcinoma usually involving the foot. Only 13 cases have been described in the oral cavity, none of which was in the English-language literature. We describe a 56-year-old man who presented with a soft exophytic mass in the maxillary gingiva, alveolar bone destruction, and loosening of the teeth. Histopathologic study revealed thin papillary projections covered by a thick keratin layer in the superficial areas and multiple, branching keratin-filled crypts ...
Tópico(s): Cancer Diagnosis and Treatment
2002 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Abraham Hirshberg, Avital Kozlovsky, Devorah Schwartz‐Arad, Ofer Mardinger, Ilana Kaplan,
Peripheral giant cell granuloma (PGCG) is a well-circumscribed lesion confined to the alveolar and gingival mucosa. PGCG is considered a reactive lesion caused by local irritation or trauma. The objectives of the present study were to evaluate the incidence of PGCG in peri-implant lesions submitted for histologic examination, to establish its correlation with implant failure, and to discuss its pathogenesis.The study was conducted on 25 periimplant biopsy specimens submitted for histological examination ...
Tópico(s): Musculoskeletal synovial abnormalities and treatments
2003 - Wiley | Journal of Periodontology
Yakir Anavi, Ilana Kaplan, Mete Citir, Shlomo Calderon,
Abstract Objectives. Clear cells have been reported in approximately 8% of cases of calcifying epithelial odontogenic tumor (CEOT). The purpose of this study was to describe the clinical and radiographic features of clear-cell CEOT (CCEOT). Study Design. Eighteen cases of CCEOT were identified by review of the literature from 1958 to 2001, and a new one was added (total 19; 12 central, 7 peripheral). Results. Fourteen tumors (74%) were located in the mandible, with the central lesions favoring the posterior ...
Tópico(s): Soft tissue tumor case studies
2003 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Abraham Hirshberg, Igor Tsesis, Zvi Metzger, Ilana Kaplan,
We sought to evaluate the incidence and clinical outcome of an accidental finding of actinomycotic colonies in periapical lesions submitted for histologic examination.The study included all periapical biopsy specimens submitted for histologic examination between 1997 and 2000. Sections of paraffin-embedded tissues, 5 microm, were cut and stained by using hematoxylin and eosin, periodic acid-Schiff, and the Gram stain. The presence of typical branching colonies of filamentous bacteria staining positive ...
Tópico(s): Sinusitis and nasal conditions
2003 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Orly Livny, Ilana Kaplan, Ram Reifen, Sylvie Polak‐Charcon, Zecharia Madar, Betty Schwartz,
Abstract We established distinctive monolayer and organotypic cell culture techniques to assess possible differences in cross-talk and spatial and structural organization of oral cancer cells compared with normal oral cells and also to evaluate possible differential responses of the cells to carotenoids. In monolayers, we investigated the effect of lycopene on the proliferation of an established oral cancer cell line, KB-1, and compared it with a primary cell line obtained from normal oral mucosa. ...
Tópico(s): Lipid metabolism and biosynthesis
2003 - Routledge | Nutrition and Cancer
Riri S. Manor, Yakir Anavi, Ilana Kaplan, Shlomo Calderon,
Objectives: To present five new cases of glandular odontogenic cyst (GOC) and to review the radiological features at presentation as reported in the English literature. Methods: From 1993 to 2002, five patients in our department were diagnosed with GOC based on histopathological findings and supported by radiography and CT. The radiographic features of the new GOC cases were analysed in addition to 51 literature cases. Results: There were 31 male and 25 female patients, aged 14–90 years (mean 50 years). ...
Tópico(s): Soft tissue tumor case studies
2003 - Oxford University Press | Dentomaxillofacial Radiology
Ilana Kaplan, Shlomo Calderon, Amos Buchner,
Tópico(s): Oral and Maxillofacial Pathology
1994 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Avraham Hirshberg, Ilana Kaplan, Amos Buchner,
The calcifying odontogenic cyst (COC) has been reported to be associated with odontoma in about 24% of cases. Separation of the cases of COC associated with odontoma (COCaO) may lead to a better understanding of the pathogenesis of this lesion. A screen of the literature revealed 52 cases of COCaO. The male to female ratio was 1:1.9, with a mean age of 16 years. The most common location was the maxilla (61.5%). The radiographic appearance of most cases (80.5%) was of a well-defined, mixed radiolucent- ...
Tópico(s): Tumors and Oncological Cases
1994 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Ilana Kaplan, Yakir Anavi, Abraham Hirshberg,
The present review analyzes the accumulated data from all cases of glandular odontogenic cyst (GOC) reported in the English language literature. In the 20 years since it was first described, 111 cases have been reported, an incidence of 0.2% of odontogenic cysts. The age range is 14–75, mean 45.7, with a M/F ratio of 1.3:1. GOC has a predilection for the mandible (70%), affecting both anterior and posterior areas. It is typically radiolucent, well defined, either unilocular (53.8%) or multilocular ( ...
Tópico(s): Soft tissue tumor case studies
2008 - Wiley | Oral Diseases
Ilana Kaplan, Limor Zuk‐Paz, Ändy Wolff,
To investigate the association of salivary flow rates with oral symptoms and oral mucosal status.The study population included 462 Israeli subjects attending a xerostomia clinic. After patient history and oral mucosal examination, major gland sialometry, and complementary tests, patients were divided into 6 groups: drug-induced salivary gland hypofunction (SGH), Sjögren syndrome (SS), radiation-induced SGH, idiopathic SGH, xerostomia without SGH, and control.Oral mucosal alterations were more prevalent ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2008 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Ilana Kaplan, Zoe Nicolaou, Dorian Hatuel, Shlomo Calderon,
Osteomas are relatively rare benign osteogenic neoplasms, characterized by the proliferation of compact and/or cancellous bone. Osteomas can develop as peripheral (periosteal) masses attached to the cortical plates or as central lesions arising from endosteal bone surfaces. Although multiple osteomas of the jaws are a hallmark of Gardner syndrome (familial adenomatous polyposis), nonsyndromic cases are typically solitary. A search of the literature identified 91 well documented cases of solitary osteoma ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2008 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Ändy Wolff, Limor Zuk‐Paz, Ilana Kaplan,
The intake of medications is a major aetiologic factor of xerostomia. The purpose of this study was to investigate the selective influence of medication categories on flow rates of individual major salivary glands.The effect of each medication category on salivary flow rates was determined by dichotomy comparisons between users and non-users. A total of 246 patients were included, 79 males and 167 females aged 13-92 years (mean 63 years). Of these, 200 used medications, which were grouped according ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2008 - Wiley | Gerodontology
Șerban Țovaru, Ioanina Părlătescu, Anca‐Silvia Dumitriu, Alexandru Bucur, Ilana Kaplan,
Background: Wilson disease (WD) is a hereditary disease inhibiting copper release from the liver. Multi‐organ manifestations involve the liver, nervous system, kidneys, eyes, heart, and skin. Elastic fiber damage is a complication of the most frequently used medication in the treatment of WD D‐penicillamine (D‐PCA). These changes have very rarely been described in the oral cavity. The article describes oral complications associated with WD and its treatment by D‐PCA. Methods: Clinical, radiographic, ...
Tópico(s): Oral Health Pathology and Treatment
2010 - Wiley | Journal of Periodontology
Ahmmad Safadi, Dan M. Fliss, Josephine Issakov, Ilana Kaplan,
Tópico(s): Head and Neck Surgical Oncology
2010 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Abraham Hirshberg, Anna Shnaiderman-Shapiro, Ilana Kaplan, Rannan Berger,
The oral region is an uncommon site for metastatic tumour cell colonization and is usually evidence of a wide spread disease. In 25% of cases, oral metastases were found to be the first sign of the metastatic spread and in 23% it was the first indication of an undiscovered malignancy at a distant site. The jawbones, particularly the mandible, were more frequently affected than the oral soft tissues (2:1). In the oral soft tissues, the attached gingiva was the most commonly affected site (54%). The ...
Tópico(s): Oral and gingival health research
2007 - Elsevier BV | Oral Oncology
Amir Shuster, Benjamin Shlomi, Vadim Reiser, Ilana Kaplan,
Odontogenic keratocyst (OKC), which was originally described by Philipsen 1 in 1956, has distinctive clinical and histologic characteristics. The histologic features of OKC include a thin epithelial lining of uniform thickness, with palisading of basal cells and a thin corrugated layer of parakeratin. OKCs have a high recurrence rate, which can be attributed both to the high proliferative activity of the epithelial lining and to the extension along the bony cancellous spaces, which makes complete ...
Tópico(s): Head and Neck Surgical Oncology
2011 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Ilana Kaplan, Tali Levin, Alexandru D.P. Papoiu, Nishel Patel, Tejesh Patel, Shlomo Calderon, M.M. Littner, Francis McGlone, Gil Yosipovitch,
Background: Burning mouth syndrome (BMS) is a chronic orofacial pain syndrome that occurs in middle‐aged and postmenopausal women and poses a therapeutic challenge to dermatologists and dentists. It has been suggested previously that BMS is a small‐fiber neuropathy. Aims: This study was designed to examine thermal sensory and pain thresholds in the oral mucosa and chin, both innervated by the trigeminal nerve, in patients with BMS, as well as in healthy controls. In addition, the study proposed to ...
Tópico(s): Temporomandibular Joint Disorders
2011 - Wiley | Skin Research and Technology
Yoram Cohen, Nitza Goldenberg‐Cohen, Bruria Shalmon, Tali Shani, Shirley Oren, Ninette Amariglio, Olga Dratviman‐Storobinsky, Anna Shnaiderman-Shapiro, Ran Yahalom, Ilana Kaplan, Abraham Hirshberg,
The phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma (AKT) viral oncogene pathway is involved in regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation, and cell growth. Mutations in the genes associated with the PI3K/AKT pathway including PI3K, AKT, RAS and PTEN, are infrequently found within head and neck squamous cell carcinoma and more specifically are rarely reported in oral squamous cell carcinoma (OSCC) cases. We aimed to investigate ...
Tópico(s): Vascular Tumors and Angiosarcomas
2011 - Elsevier BV | Oral Oncology
Irit Allon, Dror M. Allon, Avraham Hirshberg, Benjamin Shlomi, Beatriz Lifschitz‐Mercer, Ilana Kaplan,
J Oral Pathol Med (2012) 41 : 348–353 Background: Neurovascular hamartoma (NVH), in particular in the oral cavity, is rarely described in the literature. The low number of cases may reflect a genuine rarity of the lesion, or it may be due to its being unrecognized and/or under‐reported. Objectives: To investigate clinical and microscopic features of oral NVH and to define microscopic diagnostic criteria with emphasis on the differential diagnosis. Methods: Archival cases diagnosed as oral NVH between ...
Tópico(s): Soft tissue tumor case studies
2011 - Wiley | Journal of Oral Pathology and Medicine
Ilana Kaplan, Yael Ventura-Sharabi, Gavriel Gal, Shlomo Calderon, Yakir Anavi,
To evaluate disease dynamics, treatment results, and frequency of malignant transformation. Ten-year single center retrospective study. The study included 171 patients, 28-99 years old. Follow-up was 1-16 years. 49.5% exhibited changes in clinical presentation, with 19% yearly increase of probability for type shift. Index of extent (number of oral locations) showed a mean 40% decrease and 94.1% reported improvement. There were significant differences between treated and untreated patients (P=0.012). ...
Tópico(s): Oral and gingival health research
2011 - Springer Science+Business Media | Head and Neck Pathology
Abraham Hirshberg, Meytal Lib, Avital Kozlovsky, Ilana Kaplan,
Epithelial-mesenchymal interactions have been found to play a role in the pathogenesis of odontogenic keratocyst (OKC). In the present study we investigated the effect of inflammation in the OKC wall on the polarization colors of Picrosirius red-stained collagen fibers. 50 cases of OKC were selected and separated into two groups according to the inflammatory intensity: those with mild-to-moderate inflammation (Group A), and those with intense inflammation (Group B). The polarization colors of the collagen ...
Tópico(s): Corneal Surgery and Treatments
2006 - Elsevier BV | Oral Oncology
Abraham Hirshberg, Ninette Amariglio, Sharon Akrish, Ran Yahalom, Hanna Rosenbaum, Elimelech Okon, Ilana Kaplan,
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B-cell receptor gene rearrangements. The inflammatory infiltrate consisted in most cases of B and T lymphocytes, macrophages, abundant eosinophils, and large atypical cells. In 5 cases, ...
Tópico(s): Tumors and Oncological Cases
2006 - Oxford University Press | American Journal of Clinical Pathology
Ilana Kaplan, Ifat Manor, Ran Yahalom, Abraham Hirshberg,
To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF).Retrospective clinical and histomorphometric analysis of all cases diagnosed as CGCG or COF between 1994 and 2002.A total of 51 cases were included in the study: CGCG (n = 23), COF (n = 25), and combined COF-CGCG (n = 3). All 3 lesions presented expansile, well-defined unilocular radiolucencies, with radiopacities (66%), root resorption ( ...
Tópico(s): Soft tissue tumor case studies
2006 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology