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Artigo Acesso aberto

Masamitsu Kanoe, Hiroshi Imagawa, Mitsuyoshi Toda, Akio Sato, Makoto Inoue, Yasunori Yoshimoto,

A survey was conducted on the occurrence of hepatic abscesses among slaughtered cattle in Yamaguchi Prefecture, Japan, by bacteriological examination. The results obtained are summarized as follows. 1. Of 867 animals slaughtered over a period from December, 1970 to August, 1971, 46 animals (5%) had hepatic abscesses of varying sizes. 2. 0f 66 hepatic abscesses found, 57 (86%) contained Fusobacterium necrophorum. In 21 of these specimens, the organism was isolated in pure culture. In the majority of ...

Tópico(s): Streptococcal Infections and Treatments

1976 - Japanese Society of Veterinary Science | The Japanese Journal of Veterinary Science

Artigo Revisado por pares

Akinori Miyashita, Yanan Wen, Nobutaka Kitamura, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji, Naoki Tomita, Katsutoshi Furukawa, Hiroyuki Arai, Takashi Asada, Yasuo Harigaya, Masaki Ikeda, Masakuni Amari, Haruo Hanyu, Susumu Higuchi, Masatoyo Nishizawa, Masaichi Suga, Yasuhiro Kawase, Hiroyasu Akatsu, Masaki Imagawa, Tsuyoshi Hamaguchi, Masahito Yamada, Takashi Morihara, Masatoshi Takeda, Takeo Takao, Kenji Nakata, Ken Sasaki, Ken Watanabe, Kenji Nakashima, Katsuya Urakami, Terumi Ooya, Mitsuo Takahashi, Takefumi Yuzuriha, Kayoko Serikawa, Seishi Yoshimoto, Ryuji Nakagawa, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama, Akiyoshi Kakita, Hitoshi Takahashi, Haruyasu Yamaguchi, Kohei Akazawa, Ichiro Kanazawa, Yasuo Ihara, Takeshi Ikeuchi, Ryozo Kuwano,

Rare non-synonymous variants of TREM2 have recently been shown to be associated with Alzheimer's disease (AD) in Caucasians. We here conducted a replication study using a well-characterized Japanese sample set, comprising 2,190 late-onset AD (LOAD) cases and 2,498 controls. We genotyped 10 non-synonymous variants (Q33X, Y38C, R47H, T66M, N68K, D87N, T96K, R98W, H157Y, and L211P) of TREM2 reported by Guerreiro et al. (2013) by means of the TaqMan and dideoxy sequencing methods. Only three variants, R47H, ...

Tópico(s): Neurological Disease Mechanisms and Treatments

2014 - IOS Press | Journal of Alzheimer s Disease

Revisão Acesso aberto Revisado por pares

Akinori Miyashita, Asako Koike, Gyungah Jun, Li‐San Wang, Satoshi Takahashi, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji, Naoki Tomita, Hiroyuki Arai, Takashi Asada, Yasuo Harigaya, Masaki Ikeda, Masakuni Amari, Haruo Hanyu, Susumu Higuchi, Takeshi Ikeuchi, Masatoyo Nishizawa, Masaichi Suga, Yasuhiro Kawase, Hiroyasu Akatsu, Kenji Kosaka, Takayuki Yamamoto, Masaki Imagawa, Tsuyoshi Hamaguchi, Masahito Yamada, Takashi Moriaha, Masatoshi Takeda, Takeo Takao, Kenji Nakata, Yoshikatsu Fujisawa, Ken Sasaki, Ken Watanabe, Kenji Nakashima, Katsuya Urakami, Terumi Ooya, Mitsuo Takahashi, Takefumi Yuzuriha, Kayoko Serikawa, Seishi Yoshimoto, Ryuji Nakagawa, Jong‐Won Kim, Chang‐Seok Ki, Hong‐Hee Won, Duk L. Na, Sang Won Seo, Inhee Mook‐Jung, Peter St George‐Hyslop, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Makiko Yoshida, Nao Nishida, Katsushi Tokunaga, Ken Yamamoto, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Gerard D. Schellenberg, Lindsay A. Farrer, Ryozo Kuwano,

To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide significance was observed with 12 SNPs in the APOE region. ...

Tópico(s): Genetic Associations and Epidemiology

2013 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Revisado por pares

Akinori Miyashita, Asako Koike, Gyungah Jun, Li‐San Wang, Satoshi Takahashi, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji, Naoki Tomita, Hiroyuki Arai, Takashi Asada, Yasuo Harigaya, Masaki Ikeda, Masakuni Amari, Haruo Hanyu, Susumu Higuchi, Takeshi Ikeuchi, Masatoyo Nishizawa, Masaichi Suga, Yasuhiro Kawase, Hiroyasu Akatsu, Kenji Kosaka, Takayuki Yamamoto, Masaki Imagawa, Tsuyoshi Hamaguchi, Masahito Yamada, Takashi Morihara, Masatoshi Takeda, Takeo Takao, Kenji NAKATA, Yoshikatsu Fujisawa, Ken Sasaki, Ken Watanabe, Kenji Nakashima, Katsuya Urakami, Terumi Ooya, Mitsuo Takahashi, Takefumi Yuzuriha, Kayoko Serikawa, Seishi Yoshimoto, Ryuji Nakagawa, Jong-Won Kim, Chang‐Seok Ki, Hong‐Hee Won, Duk L. Na, Sang Won Seo, Inhee Mook‐Jung, Peter St George‐Hyslop, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak‐Vance, Makiko Yoshida, Nao Nishida‐Aoki, Katsushi Tokunaga, Ken Yamamoto, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Gerard D. Schellenberg, Lindsay A. Farrer, Ryozo Kuwano,

To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC).In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016).Genome-wide significance was observed with 12 SNPs in the APOE region. ...

Tópico(s): Retinoids in leukemia and cellular processes

2013 - Public Library of Science | PLoS ONE

Artigo Revisado por pares

Yuta Yoshimoto, Kazuo Azuma, Atsushi Miya, Eiichi Makino, Hidekazu Nakamoto, Nobutaka Abe, Masashi Kaburagi, Hisaki Ueda, Kohei Kuroda, Takeshi Tsuka, Akihiko Sugiyama, Tomohiro Imagawa, Yusuke Murahata, Norihiko Ito, Tomohiro Osaki, Tadashi Shimizu, Yoshiharu Okamoto,

Cryoablation is a minimally invasive cancer treatment. In this study, the effects of cryoablation on normal rabbit bone were evaluated using imaging and histopathological examinations. Cryoablation was performed using a Cryo-Hit (Galil Medical, Yokneam, Israel). Under anesthesia, one cryoablation needle was inserted at the center of the femur (day 0). To create an ice ball (2 × 3 cm), two 10-min freeze cycles were performed, separated by a 5-min thaw cycle. During cryoablation, changes in the bone and ...

Tópico(s): Bone health and treatments

2014 - Elsevier BV | Cryobiology

Artigo Revisado por pares

Hirokazu Tsukahara, Kiyoshi Kikuchi, Katsuji Nakamura, Masahiro Yoshimoto, Masakazu Saito, Masakatsu Sudo,

... Science®Google Scholar 4 Hashida S., Nakagawa K., Imagawa M. et al. Use of inorganic salts to ...

Tópico(s): Pediatric Urology and Nephrology Studies

1990 - Wiley | Pediatrics International