Miranda Fábio Alexandre, João Chambel, Almeida Catarina, Pires Damiana, Inês Duarte, Esteves Liliana, Paulo Maranhão,
... Alexandre S Miranda João Chambel Catarina Almeida Damiana Pires Inês Duarte Liliana Esteves Paulo Maranhão Google Fábio Alexandre S Miranda João Chambel Catarina Almeida Damiana Pires Inês Duarte Liliana Esteves Paulo Maranhão Google Scholar Fábio Alexandre S Miranda João Chambel Catarina Almeida Damiana Pires Inês Duarte Liliana Esteves Paulo Maranhão PubMed Fábio Alexandre S Miranda João Chambel Catarina Almeida Damiana Pires Inês Duarte Liliana Esteves Paulo Maranhão Related Article in ...
Tópico(s): Saffron Plant Research Studies
2016 - Frontiers Media | Frontiers in Marine Science
Mario Mandalà, Paul Lorigan, Maria Chiara Sergi, Naima Benannoune, Patricio Serra, Maria Grazia Vitale, Diana Giannarelli, Ana Arance, Eva Muñoz‐Couselo, Bart Neyns, Marco Tucci, Michele Guida, Francesco Spagnolo, Ernesto Rossi, Marcella Occelli, Paola Queirolo, Pietro Quaglino, Roberta Depenni, Barbara Merelli, Joanna Placzke, Anna Maria Di Giacomo, Michele Del Vecchio, Alice Indini, Inês Pires da Silva, Alexander M. Menzies, Georgina V. Long, Caroline Robert, Piotr Rutkowski, Paolo A. Ascierto,
Ipilimumab plus nivolumab (COMBO) is the standard treatment in asymptomatic patients with melanoma brain metastases (MBM). We report a retrospective study aiming to assess the outcome of patients with MBM treated with COMBO outside clinical trials.
Tópico(s): Cancer Immunotherapy and Biomarkers
2024 - Elsevier BV | European Journal of Cancer
Rachael M. Zemek, Valsamo Anagnostou, Inês Pires da Silva, Georgina V. Long, W. Joost Lesterhuis,
Tópico(s): Immune cells in cancer
2024 - Nature Portfolio | Nature reviews. Cancer
Ana Merino, Ricardo Araújo, Luciano Pereira, Joana Campos, Luísa Barreiros, Marcela A. Segundo, Nádia Silva, Carolina F. F. A. Costa, Janete Quelhas‐Santos, Fábio Trindade, Inês Falcão‐Pires, Inês S. Alencastre, Ioana Bancu, Benedita Sampaio‐Maia,
Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and a well-established risk factor for the development of cardiovascular disease (CVD). Gut dysbiosis may contribute to CVD and inflammation in CKD patients. Nonetheless, the role of gut and blood microbiomes in CKD-associated VC remains unknown. Therefore, this pilot study aimed to explore the link between gut and blood microbiomes and VC in CKD patients on peritoneal dialysis (CKD-PD). Our results showed relative changes ...
Tópico(s): Oral and gingival health research
2022 - Multidisciplinary Digital Publishing Institute | Biomolecules
José Magalhães, Inês Falcão‐Pires, Inês O. Gonçalves, José Lumini‐Oliveira, Inês Marques‐Aleixo, Emanuel Passos, Sílvia Rocha‐Rodrigues, Nuno G. Machado, Ana C. Moreira, Daniela Miranda‐Silva, Cosme Moura, Adelino Leite‐Moreira, Paulo J. Oliveira, Joan Ramón Torrella, António Ascensão,
Background Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function. Methods Two-sets of rats were divided into normoxic-sedentary (NS), normoxic-exercised (NE, 1 h/day/5 weeks treadmill-running), hypoxic- ...
Tópico(s): Heart Rate Variability and Autonomic Control
2013 - Elsevier BV | International Journal of Cardiology
Ramon Andrade de Mello, Mónica Ferreira, Sandra Costa, Bruno M. Costa, Filipa Soares Pires, Inês Neves, Maria Inês Almeida, João Cunha, Pedro Oliveira, Venceslau Hespanhol, Rui Manuel Reis,
Epidermal growth factor (EGF) and its receptor play critical roles in non-small cell lung cancer (NSCLC) carcinogenesis. A functional polymorphism in the EGF gene has been linked to increased cancer susceptibility. This study aimed to evaluate the role of the EGF +61A/G polymorphism as risk factors in NSCLC patients. For the present case-control study, we analyzed 112 NSCLC and 126 cancer-free controls from Portugal. Following DNA isolation from peripheral blood, EGF +61A/G polymorphism was assessed ...
Tópico(s): HER2/EGFR in Cancer Research
2012 - SAGE Publishing | Tumor Biology
Ricardo Passos, Ana Patrícia Correia, Damiana Pires, Pedro Pires, Inês Ferreira, Marco Simões, Beatriz do Carmo, Paulo Santos, Ana Pombo, Clélia Afonso, Teresa Baptista,
Seaweeds still possess a large undisclosed potential, mainly due to their constituent's richness, which may have several uses for society. In aquaculture, they may play a role as an ecological sustainable aquafeed supplement to increase overall health and fight pathogenic outbreaks. This study aimed to evaluate the general health modulation that the inclusion of Gracilaria gracilis could accomplish in the diet of Dicentrarchus labrax. Dried algae at 2.5% and 5% and algal extract at 0.35% inclusion ...
Tópico(s): Marine and Coastal Ecosystems
2021 - Elsevier BV | Fish & Shellfish Immunology
Ana L. Pires, Inês F. Cruz, Joana Silva, Gonçalo N. P. Oliveira, Sofia Ferreira‐Teixeira, A. M. L. Lopes, João P. Araújo, Joana Fonseca, Clara Pereira, André M. Pereira,
Inorganic–polymer composites have become promising materials to be processed by printing technologies because of their unique properties that allow the fabrication of flexible wearable electronics at reduced manufacturing costs. In the present work, a complete methodological process of assembling a flexible microthermoelectric generator based on inorganic−polymer materials is presented. The used microparticles were prepared by a top-down approach beginning with a previously prepared material by ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2019 - American Chemical Society | ACS Applied Materials & Interfaces
Helena Espírito‐Santo, Catarina Freitas Pires, Inês Queiroz Garcia, Fernanda Daniel, Alexandre Silva, Rachel L. Fazio,
The Edinburgh Handedness Inventory (EHI) is persistently the most used inventory to evaluate handedness, being neuropsychological investigation and clinical practice. Despite this, there is no information on how this instrument functions in a Portuguese population. The objective of this study was therefore to examine the sociodemographic influences on handedness and establish psychometric properties of the EHI in a Portuguese sample. The sample consisted of 342 adults (157 men and 185 women), assessed ...
Tópico(s): Hearing Impairment and Communication
2017 - Taylor & Francis | Applied Neuropsychology Adult
José Carlos Curvelo Santana, Clara Giraudi, Emilio Marengo, Elisa Robotti, Sara Moreno Pires, Inês Nunes, Elvira M.S.M. Gaspar,
Tópico(s): Toxic Organic Pollutants Impact
2013 - Springer Science+Business Media | Environmental Science and Pollution Research
Camelia Quek, Aditya Pratapa, Xinyu Bai, Ghamdan Al‐Eryani, Inês Pires da Silva, Aaron T. Mayer, Nenad Bartonicek, Kate Harvey, Nigel Maher, Jordan W. Conway, Rebecca J. Kasalo, Bassem Ben Cheikh, Oliver Braubach, Umaimainthan Palendira, Robyn P.M. Saw, Jonathan R. Stretch, Kerwin F. Shannon, Alexander M. Menzies, Richard A. Scolyer, Georgina V. Long, Alexander Swarbrick, James S. Wilmott,
Heterogeneous resistance to immunotherapy remains a major challenge in cancer treatment, often leading to disease progression and death. Using CITE-seq and matched 40-plex PhenoCycler tissue imaging, we performed longitudinal multimodal single-cell analysis of tumors from metastatic melanoma patients with innate resistance, acquired resistance, or response to immunotherapy. We established the multimodal integration toolkit to align transcriptomic features, cellular epitopes, and spatial information ...
Tópico(s): CAR-T cell therapy research
2024 - Cell Press | Cell Reports
S. G. Sousa, Vasco Pinto, Filipe Vaz da Silva, Tiago Ribeiro da Costa, Armindo Fernandes, Rodrigo Batata, Carolina Noronha, João Silva, Sónia Ferreira, Salomé Sobral Sousa, Célia Alves, Rui Rangel, Alfredo Calheiros, _ _, Jorge M. Antunes, Miguel Fidalgo, Ana Grande, Gonçalo Figueiredo, L.A. Rocha, Eduardo Grala da Cunha, Miguel A. Ferreira, Sérgio Rodrigues Moreira, Ana Lúcia Machado, Márcia Tizziani, Carla Silva, Elsa Silva, Joaquim Reis, Mário Gomes, Célia Pinheiro, Dora Simões, Isabel Ribeiro, Pedro Amorim, Sara Barbeiro, Vanessa Teixeira, Sílvia Helena Henriques Camelo, Maria Laura Gonçalves, Graça Maria Alves dos Santos Magalhães, Ana Cristina Rodrigues Lacerda, Ana Paula Couto, Ana Paula Silva, Ana Bela Sarmento‐Ribeiro, Ana Rita Poças, Anabela Neves, Andreia Portela, Andreia Preto, Andreia Queirós, António de Castro Caeiro, Ariana Rocha, Bruna Mateus, Cristiana Pereira, Daniel Ferreira da Cunha, Daniela M. Sousa, Elsa Oliveira, Ema Paula Ribeiro, Hélder R. O. Rocha, Inês A. Barbosa, Inês Carvalho, Inês Cunha, Inês Lima, Inês Falcão‐Pires, Inês Maria Meneses dos Santos, Isabel Pavão Martins, Isabel Ramos, Joana Silva, Jorge Castanheira, J.A.M. Ferreira, Júlia Leitão, Juliana Silva, Leonela Margarita Torre, Lucília Alves, Vasco Pinto, Margarida Chagas Lopes, Maria do Céu Amaral, Maria João Rocha Melo, Maria Monteiro, Maria Teresa Lisboa, Mariana Silva, Marília Saffarizadeh, Marisa Moreira, Marlene Luz, Noémia Costa, Patrícia Capas, Rita Quintela, Rosa Silva, Rui Neto, Rui Santos, Sílvia Silva, Simão Pinto, Sofia Queirós, Tiago Oliveira,
Timing of mobilization after chronic subdural hematoma (cSDH) surgery is highly heterogeneous among neurosurgical centers. Past studies have suggested that early mobilization may reduce medical complications without increasing recurrence, but evidence remains scarce. The purpose of this study was to compare an early mobilization protocol with a 48-hour bed rest practice, with a focus on the occurrence of medical complications.The GET-UP Trial is a prospective, randomized, unicentric, open-label study ...
Tópico(s): Pituitary Gland Disorders and Treatments
2023 - American Association of Neurological Surgeons | Journal of neurosurgery
Aljosja Rogiers, Carlo Tondini, Joe M. Grimes, Megan H. Trager, Sharon H. Nahm, Leyre Zubiri, Neha Papneja, Arielle Elkrief, Jessica S.W. Borgers, April A. N. Rose, Johanna Mangana, Michael Erdmann, Inês Pires da Silva, Christian Posch, Axel Hauschild, Lisa Zimmer, Paola Queirolo, Caroline Robert, Karijn P.M. Suijkerbuijk, Paolo A. Ascierto, Paul Lorigan, Richard D. Carvajal, Osama E. Rahma, Mario Mandalà, Georgina V. Long,
... Jessica Borgers, April Rose, Johanna Mangana, Michael Erdmann, Ines Pires da Silva, Christian Posch, Axel Hauschild, Lisa Zimmer, ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2020 - American Association for Cancer Research | Clinical Cancer Research
M. A. Castelo-Branco, Jaqueline Jesus Santana dos Santos, Olga Moreira, A. B. de Oliveira, F. P. Pires, Inês Magalhães, S. H. L. Dias, Lorys Fernandes, José Telo da Gama, J.M Vieira e Silva, José Ramalho Ribeiro,
The results of an ongoing study of soil improvement using pyrite-rich waste from the Neves-Corvo copper mine as an amendment, are reported for an area in southern Portugal. The application of pyrite to the calcareous soils resulted in the increased availability of certain trace elements, an increase in nutritive parameters, and an increase in dry matter production. This application does not appear to lead to pollution problems in surface waters or toxicological problems in grazing animals.
Tópico(s): Agricultural Science and Fertilization
1999 - Elsevier BV | Journal of Geochemical Exploration
Produção Nacional
Revisado por pares
Lídia Rosi Medeiros, Célia Scapin Duarte, Daniela Dornelles Rosa, Maria Isabel Albano Edelweiss, Marcia Edelweiss, Fábio Rosa Silva, Erik Paul Winnnikow, Patrícia Duarte Simões Pires, Maria Inês da Rosa,
Tópico(s): Advanced MRI Techniques and Applications
2011 - Springer Science+Business Media | Breast Cancer Research and Treatment
James P. Pham, Anthony M. Joshua, Inês Pires da Silva, Reinhard Dummer, Simone M. Goldinger,
Abstract Purpose of Review In the preceding decade, the management of metastatic cutaneous melanoma has been revolutionised with the development of highly effective therapies including immune checkpoint inhibitors (specifically CTLA-4 and PD-1 inhibitors) and targeted therapies (BRAF and MEK inhibitors). The role of chemotherapy in the contemporary management of melanoma is undefined. Recent Findings Extended analyses highlight substantially improved 5-year survival rates of approximately 50% in patients ...
Tópico(s): CAR-T cell therapy research
2023 - Springer Science+Business Media | Current Oncology Reports
Tuba N. Gide, Elizabeth Paver, Zarwa Yaseen, Nigel Maher, Nurudeen A. Adegoke, Alexander M. Menzies, Inês Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer,
Lymphocyte-activation gene-3 (LAG-3), an immune checkpoint receptor, negatively regulates T-cell function and facilitates immune escape of tumors. Dual inhibition of LAG-3 and programmed cell death receptor-1 (PD-1) significantly improved progression-free survival (PFS) in metastatic melanoma patients compared to anti-PD-1 therapy alone. Investigating the utility of LAG-3 expression as a biomarker of response to anti-LAG-3 + anti-PD-1 immunotherapy is of great clinical relevance. This study sought to ...
Tópico(s): Immunotherapy and Immune Responses
2023 - Landes Bioscience | OncoImmunology
Hansol Lee, Angela L. Ferguson, Camelia Quek, Ismael A. Vergara, Inês Pires da Silva, Ruth Allen, Tuba N. Gide, Jordan W. Conway, Lambros T. Koufariotis, Nicholas K. Hayward, Nicola Waddell, Matteo S. Carlino, Alexander M. Menzies, Robyn P.M. Saw, Elena Shklovskaya, Helen Rizos, Serigne Lo, Richard A. Scolyer, Georgina V. Long, Umaimainthan Palendira, James S. Wilmott,
Abstract Purpose: This study characterizes intratumoral macrophage populations within baseline melanoma biopsies from patients with advanced melanoma who received either anti-PD-1 monotherapy or a combination with anti-CTLA-4. Particularly, FcγRIIIa (CD16)-expressing macrophage densities were investigated for associations with response and progression-free survival. Experimental Design: Patients with advanced melanoma who received either anti-PD-1 monotherapy or combination anti-PD-1 and anti-CTLA- ...
Tópico(s): CAR-T cell therapy research
2023 - American Association for Cancer Research | Clinical Cancer Research
Patricio Serra-Bellver, Judith M. Versluis, H.K. Oberoi, Cong Zhou, Timothy D. Slattery, Yasir Khan, James R. Patrinely, Inês Pires da Silva, Clara Martínez-Vila, Natalie Cook, Donna M. Graham, Matteo S. Carlino, Alexander M. Menzies, Ana Arance, Douglas B. Johnson, Georgina V. Long, Lisa Pickering, James Larkin, Christian U. Blank, Paul Lorigan,
To assess efficacy and toxicity of combination immunotherapy with ipilimumab plus nivolumab in routine practice in a retrospective multicentre cohort of patients with advanced melanoma.This retrospective analysis included patients with advanced melanoma treated with ipilimumab and nivolumab between October 2015 and January 2020 at six centres in Australia, Europe and the United States of America. We describe efficacy outcomes (overall survival [OS], progression-free survival [PFS] and objective response ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Elsevier BV | European Journal of Cancer
Jordan W. Conway, Robert V. Rawson, Serigne Lo, Tasnia Ahmed, Ismael A. Vergara, Tuba N. Gide, Grace H. Attrill, Matteo S. Carlino, Robyn P.M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Brindha Shivalingam, Alexander M. Menzies, James S. Wilmott, Georgina V. Long, Richard A. Scolyer, Inês Pires da Silva,
The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorable outcome. There are limited data available regarding the immune microenvironment at different anatomical sites of melanoma metastases. This study sought to characterize and compare the tumor immune microenvironment of liver, brain, lung, subcutaneous (subcut) as ...
Tópico(s): CAR-T cell therapy research
2022 - BMJ | Journal for ImmunoTherapy of Cancer
Inês Pires da Silva, Tasnia Ahmed, Jennifer L. McQuade, Caroline A. Nebhan, John Park, Judith M. Versluis, Patricio Serra-Bellver, Yasir Khan, Tim Slattery, H.K. Oberoi, Selma Ugurel, Lauren E. Haydu, Rudolf Herbst, Jochen Utikal, Claudia Pföhler, Patrick Terheyden, Michael Weichenthal, Ralf Gutzmer, Peter Mohr, Rajat Rai, Jessica L. Smith, Richard A. Scolyer, Ana Arance, Lisa Pickering, James Larkin, Paul Lorigan, Christian U. Blank, Dirk Schadendorf, Michael A. Davies, Matteo S. Carlino, Douglas B. Johnson, Georgina V. Long, Serigne Lo, Alexander M. Menzies,
Currently, there are no robust biomarkers that predict immunotherapy outcomes in metastatic melanoma. We sought to build multivariable predictive models for response and survival to anti-programmed cell death protein 1 (anti-PD-1) monotherapy or in combination with anticytotoxic T-cell lymphocyte-4 (ipilimumab [IPI]; anti-PD-1 ± IPI) by including routine clinical data available at the point of treatment initiation.One thousand six hundred forty-four patients with metastatic melanoma treated with anti- ...
Tópico(s): Immunotherapy and Immune Responses
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Rebecca Simpson, Erin R. Shanahan, Marcel Batten, Irene L. M. Reijers, Mark Read, Inês Pires da Silva, Judith M. Versluis, Rosilene V. Ribeiro, Alexandra S. Angelatos, Jian Tan, Chandra Mani Adhikari, Alexander M. Menzies, Robyn P.M. Saw, Maria Gonzalez, Kerwin F. Shannon, Andrew J. Spillane, Rebecca Velickovic, Alexander J. Lazar, Ashish Damania, Aditya K. Mishra, Manoj Chelvanambi, Anik Banerjee, Nadim J. Ajami, Jennifer A. Wargo, Laurence Macia, Andrew Holmes, James S. Wilmott, Christian U. Blank, Richard A. Scolyer, Georgina V. Long,
Tópico(s): Tryptophan and brain disorders
2022 - Nature Portfolio | Nature Medicine
José Garcia‐Pelaez, Rita Barbosa‐Matos, Silvana Lobo, Alexandre Dias, Luzia Garrido, Sérgio Castedo, Sónia Sousa, Hugo Pinheiro, Liliana Sousa, Rita Monteiro, Joaquín J. Maqueda, Susana Fernandes, Fátima Carneiro, Nádia Pinto, Carolina Lemos, Carla Pinto, Manuel R. Teixeira, Stefan Aretz, Svetlana Lagercrantz, Judith Balmañà, Ana Blatnik, Patrick R. Benusiglio, Maud Blanluet, Vincent Bours, Hilde Brems, Joan Brunet, Daniele Calistri, Gabriel Capellá, Sergio Carrera, Chrystelle Colas, Karin Dahan, Robin De Putter, Camille Desseignés, Elena Domínguez‐Garrido, Conceição Egas, D. Gareth Evans, Damien Féret, Eleanor Fewings, Rebecca C. Fitzgerald, Florence Coulet, María Garcia-Barcina, Maurizio Genuardi, Lisa Golmard, Karl Hackmann, Helen Hanson, Elke Holinski‐Feder, Robert Hüneburg, Mateja Krajc, Kristina Lagerstedt‐Robinson, Conxi Lázaro, Marjolijn J. L. Ligtenberg, Cristina Martínez-Bouzas, Sonia Merino, G Michils, Srdjan Novaković, Ana Patiño‐García, Guglielmina Nadia Ranzani, Evelin Schröck, Inês Pires da Silva, Catarina Silveira, José Luís Soto, Isabel Spier, Verena Steinke‐Lange, Gianluca Tedaldi, María‐Isabel Tejada, Emma R. Woodward, Marc Tischkowitz, Nicoline Hoogerbrugge, Carla Oliveíra,
Background Truncating pathogenic or likely pathogenic variants of CDH1 cause hereditary diffuse gastric cancer (HDGC), a tumour risk syndrome that predisposes carrier individuals to diffuse gastric and lobular breast cancer.Rare CDH1 missense variants are often classified as variants of unknown significance.We conducted a genotypephenotype analysis in families carrying rare CDH1 variants, comparing cancer spectrum in carriers of pathogenic or likely pathogenic variants (PV/LPV; analysed jointly) or ...
Tópico(s): Genomics and Rare Diseases
2022 - Elsevier BV | The Lancet Oncology
Alexander M. Menzies, Inês Pires da Silva, Claudia Trojaniello, Elisabeth Vieu, Rodabe N. Amaria, Lisa Zimmer, Serigne Lo, Elizabeth M. Burton, Hussein A. Tawbi, Dirk Schadendorf, Jean‐Jacques Grob, Paolo A. Ascierto, Georgina V. Long,
Tópico(s): Melanoma and MAPK Pathways
2022 - Massachusetts Medical Society | New England Journal of Medicine
Grace H. Attrill, C. Owen, Tasnia Ahmed, Ismael A. Vergara, Andrew J. Colebatch, Jordan W. Conway, Kazi Nahar, John F. Thompson, Inês Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Serigne Lo, Umaimainthan Palendira, Richard A. Scolyer, Georgina V. Long, James S. Wilmott,
Background Adjuvant immune checkpoint inhibitor (ICI) immunotherapies have significantly reduced the recurrence rate in high-risk patients with stage III melanoma compared with surgery alone. However, 48% of anti-PD-1-treated patients will develop recurrent disease within 4 years. There is a need to identify biomarkers of recurrence after adjuvant ICI to enable identification of patients in need of alternative treatment strategies. As cytotoxic T cells are critical for the antitumor response to anti- ...
Tópico(s): Immunotherapy and Immune Responses
2022 - BMJ | Journal for ImmunoTherapy of Cancer
Maria G. Leichtweis, Adriana K. Molina, Tânia C. S. P. Pires, María Inês Días, Ricardo C. Calhelha, Khaldoun Bacharı, Borhane Eddine Chérif Ziani, M. Beatriz P.P. Oliveira, Carla Pereira, Lillian Barros,
Pumpkin fruits are widely appreciated and consumed worldwide. In addition to their balanced nutritional profile, pumpkin species also present valuable bioactive compounds that confer biological and pharmacological properties to them. However, the seeds, peels, and fibrous strands resulting from pumpkin processing are still poorly explored by the food industry. The current study used those fruit components from the genotypes of pumpkin that are economically significant in Portugal and Algeria to ...
Tópico(s): Seed and Plant Biochemistry
2022 - Multidisciplinary Digital Publishing Institute | Molecules
Inês Pires da Silva, Tasnia Ahmed, Irene L. M. Reijers, Alison M. Weppler, Allison Betof Warner, James R. Patrinely, Patricio Serra-Bellver, Clara Allayous, Joanna Mangana, Khang Nguyen, Lisa Zimmer, Claudia Trojaniello, Dan Stout, Megan Lyle, Oliver Klein, Camille L. Gérard, Olivier Michielin, Andrew Haydon, Paolo A. Ascierto, Matteo S. Carlino, Célèste Lebbe, Paul Lorigan, Douglas B. Johnson, Shahneen Sandhu, Serigne Lo, Christian U. Blank, Alexander M. Menzies, Georgina V. Long,
Background Anti-PD-1 therapy (hereafter referred to as anti-PD-1) induces long-term disease control in approximately 30% of patients with metastatic melanoma; however, two-thirds of patients are resistant and will require further treatment. We aimed to determine the efficacy and safety of ipilimumab plus anti-PD-1 (pembrolizumab or nivolumab) compared with ipilimumab monotherapy in patients who are resistant to anti-PD-(L)1 therapy (hereafter referred to as anti-PD-[L]1). Methods This multicentre, ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Elsevier BV | The Lancet Oncology
Felicity Newell, Inês Pires da Silva, Peter A. Johansson, Alexander M. Menzies, James S. Wilmott, Venkateswar Addala, Matteo S. Carlino, Helen Rizos, Kátia Nones, Jarem Edwards, Vanessa Lakis, Stephen H. Kazakoff, Pamela Mukhopadhyay, Peter M. Ferguson, Conrad Leonard, Lambros T. Koufariotis, Scott Wood, Christian U. Blank, John F. Thompson, Andrew J. Spillane, Robyn P.M. Saw, Kerwin F. Shannon, John V. Pearson, Graham J. Mann, Nicholas K. Hayward, Richard A. Scolyer, Nicola Waddell, Georgina V. Long,
We concurrently examine the whole genome, transcriptome, methylome, and immune cell infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated with anti-PD-1 with or without anti-CTLA-4. We show that high tumor mutation burden (TMB), neoantigen load, expression of IFNγ-related genes, programmed death ligand expression, low PSMB8 methylation (therefore high expression), and T cells in the tumor microenvironment are associated with response to immunotherapy. No specific ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Cell Press | Cancer Cell
Aljosja Rogiers, Inês Pires da Silva, Chiara Tentori, Carlo Tondini, Joseph M. Grimes, Megan H. Trager, Sharon H. Nahm, Leyre Zubiri, Michael P. Manos, Peter J. Bowling, Arielle Elkrief, Neha Papneja, Maria Grazia Vitale, April A. N. Rose, Jessica S.W. Borgers, Séverine Le Roy, Joanna Mangana, Thiago Pimentel Muniz, Tim Cooksley, Jéremy Lupu, A Vaisman, Samuel D. Saibil, Marcus O. Butler, Alexander M. Menzies, Matteo S. Carlino, Michael Erdmann, Carola Berking, Lisa Zimmer, Dirk Schadendorf, Laura Pala, Paola Queirolo, Christian Posch, Axel Hauschild, Reinhard Dummer, John B.A.G. Haanen, Christian U. Blank, Caroline Robert, Ryan J. Sullivan, Paolo A. Ascierto, Wilson H. Miller, F. Stephen Hodi, Karijn P.M. Suijkerbuijk, Kerry L. Reynolds, Osama E. Rahma, Paul Lorigan, Richard D. Carvajal, Serigne Lo, Mario Mandalà, Georgina V. Long,
Patients with cancer who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to develop severe illness and die compared with those without cancer. The impact of immune checkpoint inhibition (ICI) on the severity of COVID-19 illness is unknown. The aim of this study was to investigate whether ICI confers an additional risk for severe COVID-19 in patients with cancer.
Tópico(s): Cancer survivorship and care
2021 - BMJ | Journal for ImmunoTherapy of Cancer
Lisa Haas, Anais Elewaut, Camille L. Gérard, Christian Umkehrer, Lukas Leiendecker, Malin Pedersen, Izabela Kręcioch, David Hoffmann, Maria Novatchkova, Mario Kuttke, Tobias Neumann, Inês Pires da Silva, Harriet Witthock, Michel A. Cuendet, Sebastian Carotta, Kevin J. Harrington, Johannes Zuber, Richard A. Scolyer, Georgina V. Long, James S. Wilmott, Olivier Michielin, Sakari Vanharanta, Thomas Wiesner, Anna C. Obenauf,
How targeted therapies and immunotherapies shape tumors, and thereby influence subsequent therapeutic responses, is poorly understood. In the present study, we show, in melanoma patients and mouse models, that when tumors relapse after targeted therapy with MAPK pathway inhibitors, they are cross-resistant to immunotherapies, despite the different modes of action of these therapies. We find that cross-resistance is mediated by a cancer cell–instructed, immunosuppressive tumor microenvironment that ...
Tópico(s): CAR-T cell therapy research
2021 - Nature Portfolio | Nature Cancer