Zhirong Gao, Junnan Shi, Yu Wang, Fayou Gu,
... part or in the root part of the groove, infectious materials may get into the pulp cavity when there are pathologic conditions either through accessory foramina in the crown part or through accessory formaina exposed by localized periodontitis around the groove.
Tópico(s): Oral microbiology and periodontitis research
1989 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology
Tópico(s): History of Medical Practice
1999 - Nature Portfolio | Nature Genetics
... real-time RT- PCR using a 3′-minor groove binder-DNA probe. BMC Infectious Diseases, 6, 69. Le Guyader FS, Parnaudeau S, ...
Tópico(s): Advanced Thermodynamic Systems and Engines
2016 - Wiley | EFSA Journal
Chun-Yuan Chen, Chung‐ke Chang, Yi‐Wei Chang, Shih‐Che Sue, Hsin-I Bai, Lilianty Riang, Chwan‐Deng Hsiao, Tai-huang Huang,
... region. Residues 248–280 form a positively charged groove similar to that found in the infectious bronchitis virus (IBV) nucleocapsid protein. Furthermore, the positively charged surface area is larger in the SARS-CoV construct than in the IBV. Interactions between residues 248–280 and the rest of the molecule also stabilize the formation of an octamer in the asymmetric unit. Packing of the octamers in the crystal forms two parallel, basic helical grooves, which may be oligonucleotide attachment sites, and suggests ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2007 - Elsevier BV | Journal of Molecular Biology
Produção Nacional
Revisado por pares
Ana Paula Fernandes, Maria Alice G Gonçalves, Raquel B Zavanella, José Fernando C. Figueiredo, Eduardo Antônio Donadi, Maria Lourdes Veronese Rodrigues,
... molecules exhibiting particular motifs in the peptide binding groove [18]. Cytomegalovirus is an important opportunistic infectious agent in AIDS patients that may cause considerable ...
Tópico(s): Herpesvirus Infections and Treatments
2003 - Lippincott Williams & Wilkins | AIDS
Sterling K. Clarren, DavidW. Smith, Mary Ann Sedgwick Harvey, R. H. T. Ward, Ntinos C. Myrianthopoulos,
... a hyperthermic event around the time of neural groove closureY In both of these studies the infectious agents associated with fever were diverse and, in ...
Tópico(s): Sexual Differentiation and Disorders
1979 - Elsevier BV | The Journal of Pediatrics
Michael McMenamy, John McKillen, Bernt Hjertner, István Kiss, A. Yacoub, Mikael Leijon, Catherine Duffy, Sándor Bélak, Michael Welsh, Gordon Allan,
... for the rapid, sensitive and specific detection of infectious laryngotracheitis virus (ILTV) DNA is described. A Primer-Probe Energy Transfer (PriProET) assay and 5′ conjugated Minor Groove Binder (MGB) method are compared and contrasted. Both ...
Tópico(s): Plant and Fungal Interactions Research
2011 - Elsevier BV | Journal of Virological Methods
Sigrun Häge, Manfred Marschall,
... into the complex regulatory role of hook and groove proteins during the assembly, egress and maturation of infectious virus.
Tópico(s): RNA regulation and disease
2022 - Multidisciplinary Digital Publishing Institute | Cells
Sergi Juanpere, Laia Valls, Isabel Badell, Margarita Osorio, Arantxa Gelabert, Albert Maroto, Salvador Pedraza,
... masses, inflammation and hematomas. • Distinguishing between tumour and groove pancreatitis can be challenging by cross-sectional imaging. • Infectious diseases of the duodenum are difficult to diagnose, ...
Tópico(s): Pancreatitis Pathology and Treatment
2018 - Springer Nature | Insights into Imaging
Philip Turner, William A. Denny,
... particular parasitic infections. Keywords: Drug Target Cellular, Minor Groove Binding Ligands, DNA Binding, DNA Gene expression, Parasitic infectious, Cytotoxic, Plasmodium, Falciparum, DNA replication, DNA Alkylating compounds
Tópico(s): Metal complexes synthesis and properties
2000 - Bentham Science Publishers | Current Drug Targets
Binh Nguyen, Donald Hamelberg, Christian Bailly, Pierre Colson, Jaroslav Staněk, Reto Brun, Stephen Neidle, W. David Wilson,
... dicationic amidine compounds bind in the DNA minor groove and have excellent biological activity against a range of infectious diseases. Para-substituted aromatic diamidines such as furamidine, ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2004 - Elsevier BV | Biophysical Journal
Lerato Hlaka, Michael-Jon Rosslee, Mumin Ozturk, Santosh Kumar, Suraj P. Parihar, Frank Brombacher, Abedawn I. Khalaf, Katharine C. Carter, Fraser J. Scott, Colin J. Suckling, Reto Guler,
... of new drugs approved for TB treatment. Minor groove binders (MGBs) have previously revealed promising antimicrobial activity against various infectious agents; however, they have not yet been screened ...
Tópico(s): Tuberculosis Research and Epidemiology
2017 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Mohanapriya Arumugam, Sajitha Lulu, Rajarathinam Kayathri, Pandjassarame Kangueane,
... peptide binding combinations of varying length at the groove, having an eventual effect in the host immune response to infectious agents. Here we describe the development of a ...
Tópico(s): Biochemical and Structural Characterization
2009 - Elsevier BV | Human Immunology
Andrea Di Matteo, Emilio Filippucci, Edoardo Cipolletta, Matteo Ausili, María Victoria Martiré, Marco Di Carlo, Fausto Salaffi, Walter Grassi,
To determine the prevalence of the ultrasound findings indicating monosodium urate crystal deposits at the popliteal groove region in patients with gout; to evaluate the diagnostic accuracy of ultrasound in detecting monosodium urate crystal deposits at the popliteal groove region, patellar tendon and the knee hyaline cartilage; to investigate the correlation between the ultrasound findings at the popliteal groove region and the clinical features. Bilateral ultrasound assessment of the popliteal ...
Tópico(s): Veterinary medicine and
2018 - Elsevier BV | Joint Bone Spine
Laura Cipolla, Ana C. Araújo, Cristina Airoldi, Davide Bini,
Compounds that bind in the minor groove of DNA have found use in the experimental treatment of cancer and certain infectious diseases. Furthermore, agents which target and can recognize discrete sequences of DNA have the potential to offer selective therapies by modulating the ...
Tópico(s): Biochemical and Molecular Research
2009 - Bentham Science Publishers | Anti-Cancer Agents in Medicinal Chemistry
Carl L. Stanitski, Vert Mooney,
Abstract Skeletal ingrowth to vitreous carbon was tested by means of bicortical corrugated vitreous carbon dowels of various groove sizes in dog femora and humeri. After a 4‐week ingrowth period, resistance of the implants to push out loads ranged from 66 to 100 kg. Comparable data was obtained from similar sized polymethylmethacrylate and vitreous carbon‐coated graphite implants. Histologic acceptability of the vitreous carbon appeared excellent in terms of minimal foreign body giant cell and fibrous ...
Tópico(s):
1973 - Wiley | Journal of Biomedical Materials Research
Amy J. Vogler, Elizabeth M. Driebe, Judy Lee, Raymond K. Auerbach, Christopher J. Allender, Miles Stanley, Kristy Kubota, Gary L. Andersen, Lyndsay Radnedge, Patricia L. Worsham, Paul Keim, David M. Wagner,
We present TaqMan-minor groove binding (MGB) assays for an SNP that separates the Yersinia pestis strain CO92 from all other strains and for another SNP that separates North American strains from all other global strains.
Tópico(s): Vector-borne
2008 - Future Science Ltd | BioTechniques
Tópico(s): Vector-borne
1977 - Southwestern Association of Naturalists | The Southwestern Naturalist
Karin Melanie Rohrer, Markus Haug, Daniela Schwörer, Hubert Kalbacher, Ursula Holzer,
Heat-shock protein 70 (Hsp70)-peptide complexes are involved in MHC class I- and II-restricted antigen presentation, enabling enhanced activation of T cells. As shown previously, mammalian cytosolic Hsp70 (Hsc70) molecules interact specifically with HLA-DR molecules. This interaction might be of significance as Hsp70 molecules could transfer bound antigenic peptides in a ternary complex into the binding groove of HLA-DR molecules. The present study provides new insights into the distinct interaction ...
Tópico(s): Veterinary medicine and
2014 - Wiley | Immunology
George J. Hruza, Stephen N. Snow,
... basal cell carcinoma of the left nasal alar groove in a patient with acquired immunodeficiency syndrome is described. Fixation of the tissue before excision and appropriate infectious disease precautions minimize exposure to the human immunodeficiency ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
1989 - Wiley | The Journal of Dermatologic Surgery and Oncology
James F. Murphy, Herbert L. Fred,
... above and below the inguinal ligament forming the "groove" sign (Fig 1), a characteristic of lymphogranuloma venereum. 1 Infectious lymphadenitis seemed evident. Lymphogranuloma venereum topped the list ...
Tópico(s): Mycobacterium research and diagnosis
1976 - American Medical Association | JAMA
David S. P. Dearborn, Sophie Warren, Frank Hailer,
... MHC protein is a heterodimer whose peptide-binding groove is encoded by an MHC-IIA gene and an MHC-IIB gene. However, our literature review found that class II MHC papers on infectious disease or sexual selection included IIA data only ...
Tópico(s): Animal Behavior and Reproduction
2022 - Wiley | Molecular Ecology
Produção Nacional
Revisado por pares
Láuris Lucia da Silva, Cláudio Luis Donnici, Júlio César Dias Lopes, Marília Oliveira Fonseca Goulart, Fabiane C. de Abreu, Francine Santos de Paula, Carlos Bravo, Marcelo M. Santoro, Ângelo M. L. Denadai, Alexandre Martins Costa Santos, Carlos A. Montanari,
... DNA.Biscationic amidines bind in the DNA minor groove and present biological activity against a range of infectious diseases.Two new biscationic compounds (bis-α,ω- ...
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2012 - Brazilian Chemical Society | Química Nova
Miguel Ángel Jiménez‐Clavero, Montserrat Agüero, Elena San Miguel, T. Mayoral, Maria Cruz López, Marı́a José Ruano, Emny Rochell Bobadilla Romero, Federica Monaco, Andrea Polci, Giovanni Savini, Concepción Gómez-Tejedor,
... probe bound to 5'-Taq nuclease-3' minor groove binder (TaqMan MGB) was used to detect a range of isolates. This real-time RT-PCR assay could detect 5.4 x 10(-3) tissue culture infectious doses (TCID50) of virus per milliliter of sample, ...
Tópico(s): Animal Disease Management and Epidemiology
2006 - SAGE Publishing | Journal of Veterinary Diagnostic Investigation
Ellis L. Reinherz, Wonmuk Hwang, Matthew J. Lang,
... lymphocytes (CTLs) recognize "foreign" antigens bound in the groove of major histocompatibility complex (MHC) molecules (H-2 in mouse and HLA in human) displayed on altered cells. These antigens are peptide fragments of proteins derived either from infectious pathogens or cellular transformations during cancer evolution. The ...
Tópico(s): T-cell and B-cell Immunology
2023 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Hilario Flores-A, Andrea Munguı́a, Eulalia Valencia, Diego Sanchez, Araceli Rodríguez, Felicitas Manzanarez, C. Aláez, Clara Gorodezky,
... interaction of specific amino acids in the HLA groove with different infectious agents and environmental factors, are related to AML ...
Tópico(s): vaccines and immunoinformatics approaches
2015 - Elsevier BV | Human Immunology
... 11) is a largely diatonic work with an infectious groove that has rocketed Shaw to stardom, earning her ...
Tópico(s): Theater, Performance, and Music History
2022 - Taylor & Francis | Contemporary Music Review
... of the IG and TR, and for the groove (G) domains of the major histocompatibility (MH). These breakthroughs contributed to the development of IMGT databases and tools for antibody informatics and its diverse applications, such as repertoire analysis in infectious diseases, antibody engineering and humanization, and study of ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - American Society for Microbiology | Microbiology Spectrum
Ishmeet Kaur, Deepak Jakhar, Archana Singal, Chander Grover,
... source and carrier of infections. The distal nail groove, nail folds, and undersurface of the nail plate have a potential to harbor particles and infectious agents during daily routine work.[123] This undesired ...
Tópico(s): Infection Control in Healthcare
2020 - Medknow | Indian Dermatology Online Journal
F. Janssen, Ariane ZeHnsky-Gurung, Éric Caumes, Jean‐Marie Decazes,
A rapidly enlarging left inguinal adenitis, with positive groove sign, and fever, chills, malaise, hypotension, headache, scarlatiniform rash, choleroid diarrhea, and proteinuria developed in an homosexual man who was positive for human immunodeficiency virus. The needle aspiration of the inguinal mass showed group A beta-hemolytic streptococci and the blood cultures were negative, suggesting group A streptococcal cellulitis-adenitis with toxic strep syndrome. Treatment with penicillin and surgical ...
Tópico(s): Rabies epidemiology and control
1991 - Elsevier BV | Journal of the American Academy of Dermatology