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Victoria W. Fitz, Sandro Graca, Shruthi Mahalingaiah, Jing Liu, Lily Lai, Muhammad A. Butt, Mike Armour, Vibhuti Rao, Dhevaksha Naidoo, Alison Maunder, Guoyan Yang, Vaishnavi Vaddiparthi, Selma F. Witchel, Alexia S. Peña, Poli Mara Spritzer, Rong Li, Chau Thien Tay, Aya Mousa, Helena Teede, Carolyn Ee,
... common in women with polycystic ovary syndrome (PCOS). Inositol may have insulin sensitizing effects; however, its efficacy ... review and meta-analysis evaluated the efficacy of inositol, alone or in combination with other therapies, in ... in meta-analyses. Evidence suggests benefits for myo-inositol or D-chiro-inositol (DCI) for some metabolic measures and potential benefits from DCI for ovulation, but inositol may have no effect on other outcomes. Metformin ... improve waist-hip ratio and hirsutism compared to inositol, but there is likely no difference for reproductive ...
Tópico(s): Endometriosis Research and Treatment
2024 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Zdravko Kamenov, Antoaneta Gateva, Simona Dinicola, Vittorio Unfer,
Despite the beneficial effect of myo-inositol on metabolic, hormonal, and reproductive parameters of polycystic ovary syndrome (PCOS) patients, 28% to 38% could be resistant to this treatment. The ... can be a useful therapeutic approach to overcome inositol resistance and achieve ovulation in these women. This ... aimed to compare the effects of supplementing myo-inositol plus α-lactalbumin vs myo-inositol alone on reproductive and metabolic abnormalities in PCOS. ... PCOS diagnosis were randomly assigned to receive myo-inositol alone or a combination of myo-inositol and ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2023 - Multidisciplinary Digital Publishing Institute | Metabolites
Qiuran Yu, Fenglu Han, Maoxian Huang, Xiaodan Wang, Jian G. Qin, Liqiao Chen, Erchao Li,
Myo-inositol serves as an essential nutrient in many animal species. However, the optimal requirements of myo-inositol and the mechanisms by which myo-inositol is involved in nutritional regulation in crustaceans are ... the effects of 6 levels of dietary myo-inositol (20, 528, 1030, 2060, 3180 and 4235 mg/ ... gain and conditioning factors of shrimp fed myo-inositol were significantly higher than those of the 20 mg/kg myo-inositol group. The maximal hepatosomatic index was found in the 1030 mg/kg myo-inositol group. On the other hand, serum triglyceride, total ...
Tópico(s): Aquaculture disease management and microbiota
2023 - Elsevier BV | Aquaculture
Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka, Christopher Wittwer, Kenta Kikuchi, Takatoshi Iijima, Yu Kakimoto, Kenichi Hirabayashi, Daisuke Kurotaki, Henning J. Jessen, Adolfo Saiardi, Eiichiro Nagata,
Inositol pyrophosphates regulate diverse physiological processes; to better understand their functional roles, assessing their tissue-specific distribution is important. Here, we profiled inositol pyrophosphate levels in mammalian organs using an originally ... levels of diphosphoinositol pentakisphosphate (IP7) and its precursor inositol hexakisphosphate (IP6). Although their absolute levels in the ... pathway is conducive to the enteric nervous system. Inositol pyrophosphates regulate diverse physiological processes; to better understand ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2023 - Elsevier BV | Journal of Biological Chemistry
Mariano Bizzarri, Noemi Monti, Aurora Piombarolo, Antonio Angeloni, Roberto Verna,
Myo-inositol is a natural polyol, the most abundant among the nine possible structural isomers available in living organisms. Inositol confers some distinctive traits that allow for a ... the basic clusters into which organisms are partitioned. Inositol cooperates in numerous biological functions where the polyol ... obtained through the sequential addition of phosphate groups (inositol phosphates, phosphoinositides, and pyrophosphates). Overall myo-inositol and its phosphate metabolites display an entangled network, ...
Tópico(s): Pancreatic function and diabetes
2023 - Multidisciplinary Digital Publishing Institute | Nutrients
Jingjing Lu, Xinyue Tao, Ming Li, Xin Zhang, Qicun Zhou, Jiaxiang Luo, Tingting Zhu, Lefei Jiao, Min Jin,
... study aimed to evaluate the effects of dietary inositol level (0.86, 1.34, 1.40, 2. ... vannamei. The results indicated that the contents of inositol, phosphatidyl inositol (PI) and glycogen in hepatopancreas and muscle, very ... and inox were positively related to the dietary inositol levels, while the contents of glucose (GLU), crustacean ... and fbp were negatively correlated with the dietary inositol level. TG content, phosphoenolpyruvate carboxykinase (PEPCK) activity and ... 3.88 and 7.50 g kg−1 inositol diets were significantly lower compared with shrimp fed ...
Tópico(s): Physiological and biochemical adaptations
2023 - Elsevier BV | Aquaculture
Simiao Pan, Xiaobo Yan, Xiaohui Dong, Tao Li, Xiangxiang Suo, Beiping Tan, Shuang Zhang, Zhihao Li, Yuanzhi Yang, Haitao Zhang,
... present research was to assess the influence of inositol supplementation on growth performance, histological morphology of liver, ... fed isonitrogenous and isolipidic diets (16%) with various inositol levels of 0.17 g/kg (J1, the ... for 8 weeks. The results indicated that dietary inositol had a significant promoting effect on final mean ... ALT) and alkaline phosphatase (AKP) activities in the inositol-treated groups showed distinctly decreased compared with those ... group (P < 0.05). In the liver, dietary inositol could significantly increase the activities of SOD, catalase ( ...
Tópico(s): Aquaculture disease management and microbiota
2022 - Elsevier BV | Fish & Shellfish Immunology
Pablo Lazcano, Michael W. Schmidtke, Chisom J. Onu, Miriam L. Greenberg,
Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells. A recent ... mouse embryonic fibroblasts demonstrated that nuclear translocation of inositol hexakisphosphate kinase 1 (IP6K1) mediates repression of myo-inositol-3-P synthase (MIPS), the rate-limiting inositol biosynthetic enzyme. Binding of IP6K1 to phosphatidic acid ( ...
Tópico(s): Cellular transport and secretion
2022 - Elsevier BV | Journal of Biological Chemistry
Mahmoud Suliman, Kendall C. Case, Michael W. Schmidtke, Pablo Lazcano, Chisom J. Onu, Miriam L. Greenberg,
Inositol plays a significant role in cellular function and signaling. Studies in yeast have demonstrated an "inositol-less death" phenotype, suggesting that inositol is an essential metabolite. In yeast, inositol synthesis is highly regulated, and inositol levels have been shown to be a major ... the expression of hundreds of genes. Abnormalities in inositol metabolism have been associated with several human disorders. ... very little is known about the regulation of inositol synthesis and the pathways regulated by inositol in ...
Tópico(s): Pancreatic function and diabetes
2022 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Xue Su, An-Li Andrea Ko, Adolfo Saiardi,
... well-established substrate of non-protein phosphorylation is inositol, whose phosphorylation generates many important signalling molecules such ... signalling. A fundamental question to our understanding of inositol phosphorylation is how the levels of cellular inositol are controlled. While the availability of protein phosphorylation ... that control the uptake, synthesis, and removal of inositol are underexplored. Potentially, such mechanisms serve as an ... are two ways in which mammalian cells acquire inositol. The historic use of radioactive 3H-myo-inositol ...
Tópico(s): Pancreatitis Pathology and Treatment
2022 - Elsevier BV | Advances in Biological Regulation
Nicola Spotorno, Chloé Najac, Erik Stomrud, Niklas Mattsson, Sebastian Palmqvist, Danielle van Westen, Itamar Ronen, Oskar Hansson,
... investigate this hypothesis in vivo by measuring myo-inositol, a metabolite involved in astrocytic functions, with magnetic ... regarding the relationship between APOE ε4 and myo-inositol concentration. Furthermore, data supporting a relationship between APOE ε4, myo-inositol and Alzheimer’s disease pathology (amyloid-beta and ... limited. A previous study revealed differences in myo-inositol levels between APOE ε4 carriers and non-carriers ... of APOE genotype on the association between myo-inositol and the rate of amyloid-beta accumulation. In ...
Tópico(s): Dementia and Cognitive Impairment Research
2022 - Oxford University Press | Brain Communications
Philipp Gaugler, Robin Schneider, Guizhen Liu, Danye Qiu, Jonathan Weber, Jochen Schmid, Nikolaus Jork, Markus Häner, Kevin Ritter, Nicolás Fernández-Rebollo, Ricardo Fabiano Hettwer Giehl, Minh Nguyen Trung, Ranjana Yadav, Dorothea Fiedler, Verena Gaugler, Henning J. Jessen, Gabriel Schaaf, Debabrata Laha,
Inositol pyrophosphates are signaling molecules containing at least one phosphoanhydride bond that regulate a wide range of ... of phosphate esters and diphosphate groups around myo-inositol, these molecular messengers possess the highest charge density found in nature. Recent work deciphering inositol pyrophosphate biosynthesis in Arabidopsis revealed important functions of ... phosphohydrolases that convert these messengers back to their inositol polyphosphate precursors. Here, we investigate whether Arabidopsis Plant ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2022 - American Chemical Society | Biochemistry
Simiao Pan, Xiaobo Yan, Xiaohui Dong, Tao Li, Xiangxiang Suo, Hao Liu, Beiping Tan, Shuang Zhang, Zhihao Li, Yuanzhi Yang, Haitao Zhang,
... was conducted to investigate the effects of dietary inositol on growth performance, lipid metabolism, and expression of ... diets were formulated to contain graded levels of inositol (0.17 g/kg (J1), 0.62 g/ ... gradually increasing trend and significant increase in four inositol treatments (J3, J4, J5, and J6) ( P < 0. ... significant difference exhibiting in survival rate between the inositol-treated groups and the control group ( P > 0.05 ). (b) In serum, dietary inositol significantly reduced the contents of triglyceride (TG), total ...
Tópico(s): Reproductive biology and impacts on aquatic species
2022 - Wiley | Aquaculture Nutrition
F Kuhlmann, Phillip Key, Suzanne M. Hickerson, John Turk, Fong‐Fu Hsu, Stephen M. Beverley,
Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs ... catabolism may warrant further emphasis. Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid (SL), differing ... synthesize sphingomyelin (SM) and complex glycosphingolipids, Leishmania synthesize inositol phosphorylceramide (IPC) as their primary SL (19Kaneshiro E.S. Jayasimhulu K. Lester R.L. Characterization of inositol lipids from Leishmania donovani promastigotes: identification of an ...
Tópico(s): Lysosomal Storage Disorders Research
2022 - Elsevier BV | Journal of Biological Chemistry
Qiquan Zhang, Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai, Jie Zhang,
... this study, P. pastoris was exploited for high inositol production using an effective dynamic regulation strategy. Through enhancing native inositol biosynthesis pathway, knocking out inositol transporters, and slowing down carbon flux of glycolysis, an inositol-producing mutant was successfully developed and low inositol production of 0.71 g/L was obtained. The inositol production was further improved by 12.7% through introduction of heterologous inositol-3-phosphate synthase (IPS) and inositol monophosphatase (IMP) ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2022 - BioMed Central | Microbial Cell Factories
A. L. Unanyan, L.G. Pivazyan, Ekaterina Krylova, Andrey Eskin, A.A. Zakaryan, Antonina Sarkisova, А.И. Ищенко,
... study aims to compare the effect of metformin, inositol and their combinations on the efficiency in improving ... articles evaluating the effectiveness of treatment metformin and inositol on ART outcomes.Study selection The systematic review ... trials (RCTs) in English that compared metformin or inositol or metformin + inositol treatment with placebo or no treatment in women ... RCTs with comparison combination and single metformin or inositol treatment were also included.Data extraction and synthesis ... Metformin treatment were included 1891 patients, in Myo-inositol group − 281, in inositol + metformin group were included ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2022 - Informa | Gynecological Endocrinology
Giovanni Monastra, Mónica H. Vazquez‐Levin, Maria Salomè Bezerra Espinola, Gabriele Bilotta, Antonio Simone Laganà, Vittorio Unfer,
... out to investigate the effect of D-chiro-inositol, a putative aromatase down-modulator, on serum levels ... stimulating hormone, luteinizing hormone, inhibin B, D-chiro-inositol and myo-inositol serum levels were also measured. Results Male volunteers ... the 10 volunteers enrolled took oral D-chiro-inositol (1 g/day) for 1 month. Serum assays ... at baseline (control) and after treatment. D-chiro-inositol administration was associated to reduced serum levels of ... Model Assessment index was observed after D-chiro-inositol treatment, although differences did not reach statistical significance. ...
Tópico(s): Phytoestrogen effects and research
2021 - BioMed Central | Basic and Clinical Andrology
Paul Ramp, Alexander Lehnert, Susana Matamouros, Astrid Wirtz, Meike Baumgart, Michael Bott,
Scyllo-inositol has been identified as a potential drug for the treatment of Alzheimer's disease. Therefore, cost-efficient ... glutamicum with the aim to develop competitive scyllo-inositol producer strains. Initial studies revealed that C. glutamicum naturally produces scyllo-inositol when cultured with myo-inositol as carbon source. The conversion involves NAD+-dependent oxidation of myo-inositol to 2-keto-myo-inositol followed by NADPH-dependent reduction to scyllo-inositol. Use of myo-inositol for biomass formation was ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2021 - Elsevier BV | Metabolic Engineering
Adiilah Mamode Cassim, Yotam Navon, Yu Gao, Marion Décossas, Laëtitia Fouillen, Axelle Grélard, Minoru Nagano, Olivier Lambert, Delphine Bahammou, Pierre Van Delft, Lilly Maneta-Peyret, Françoise Simon-Plas, Laurent Heux, Bruno Jean, Giovanna Fragneto, Jenny C. Mortimer, Magali Deleu, Laurence Lins, Sébastien Mongrand,
... lipid classes: sphingolipids, sterols, and phospholipids. The glycosyl inositol phosphoryl ceramides (GIPCs), representing up to 40% of ... lipid classes: sphingolipids, sterols, and phospholipids. The glycosyl inositol phosphoryl ceramides (GIPCs), representing up to 40% of ... subclass of sphingolipids in plants is the glycosyl inositol phosphoryl ceramides (GIPCs). GIPCs were discovered in plants ... ceramide consists of a phosphate bound to an inositol, forming the inositol phosphoryl ceramide (IPC) backbone, which ...
Tópico(s): Cellular transport and secretion
2021 - Elsevier BV | Journal of Biological Chemistry
Meysam Zarezadeh, Azadeh Dehghani, Amir Hossein Faghfouri, Nima Radkhah, Mohammad Naemi Kermanshahi, Fatemeh Hamedi, Niyaz Mohammadzadeh Honarvar, Zohreh Ghoreishi, Alireza Ostadrahimi, Mehrangiz Ebrahimi‐Mameghani,
Abstract Background Inositol is a sugar‐alcohol and recognized as a key component of cell membrane phospholipids. It has crucial role ... some earlier studies have revealed the effect of inositol mediating glucose uptake by improving insulin sensitivity, the benefit of inositol supplementation in patients with overweight and obesity is ... This study aimed to assess the impact of inositol supplementation on body mass index (BMI) through a ... Fifteen controlled clinical trials investigating the effect of inositol on adult's BMI were finally included in ...
Tópico(s): Folate and B Vitamins Research
2021 - Wiley | Obesity Science & Practice
Han Zhao, Chuan Xing, Jiaqi Zhang, Bing He,
... oral insulin-sensitizing agents, such as metformin, thiazolidinediones, inositols, and berberine, have been proven safe and efficacious ... this study. Compared with metformin, treatment with myo-inositol + D-chiro-inositol was associated with a greater improvement in menstrual ... confidence interval (CI) 2.31-93.58]). Myo-inositol + D-chiro-inositol and metformin + thiazolidinediones combination therapies were superior to ... total testosterone levels. Thiazolidinediones, metformin + thiazolidinediones, and myo-inositol + D-chiro-inositol were associated with a lower ...
Tópico(s): Lipid metabolism and disorders
2021 - BioMed Central | Reproductive Health
Simona Dinicola, Vittorio Unfer, Fabio Facchinetti, Christophe O. Soulage, Nicholas D. E. Greene, Mariano Bizzarri, Antonio Simone Laganà, Shiao‐Yng Chan, Arturo Bevilacqua, Lali Pkhaladze, Salvatore Benvenga, Annarita Stringaro, Daniele Barbaro, Marialuisa Appetecchia, Cesare Aragona, Maria Salomè Bezerra Espinola, Tonino Cantelmi, Pietro Cavalli, Tony Chiu, Andrew J. Copp, Rosario D’Anna, Didier Dewailly, Cherubino Di Lorenzo, Evanthia Diamanti‐Kandarakis, Imelda Hernández Marín, Moshe Hod, Zdravko Kamenov, Eleni Kandaraki, Giovanni Monastra, Mario Montanino Oliva, John E. Nestler, Maurizio Nordio, Ali Cenk Özay, Olga Papalou, Giuseppina Porcaro, Nikos Prapas, Scott Roseff, Mónica H. Vazquez‐Levin, Ivana Vučenik, Artur Wdowiak,
Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Since the discovery of their involvement in endocrine signal transduction, myo-Ins ... likely in opposite ways. Given the complexity of inositol-related mechanisms of action, many of their beneficial ... and mechanisms that can allow clinicians to tailor inositol therapy and to use it in other medical ... The present paper outlines the established evidence on inositols and updates on recent research, namely concerning D- ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Che-Chia Hsu, Xian Zhang, Guihua Wang, Weina Zhang, Zhen Cai, Bo‐Syong Pan, Haiwei Gu, Chuan Xu, Guoxiang Jin, Xiang Xu, Rajesh Manne, Yan Jin, Wei Yan, Jingwei Shao, Tingjin Chen, Emily Lin, Amit Ketkar, Robert L. Eoff, Zhigang Xu, Zhong‐Zhu Chen, Hong‐yu Li, Hui‐Kuan Lin,
... underline various human diseases. Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent ... classical mode as a precursor for phosphoinositide generation. Inositol decline by IMPA1/2 deficiency elicits AMPK activation and mitochondrial fission without affecting ATP level, whereas inositol accumulation prevents AMPK-dependent mitochondrial fission. Metabolic stress or mitochondrial damage causes inositol decline in cells and mice to elicit AMPK-dependent mitochondrial fission. Inositol directly binds to AMPKγ and competes with AMP ...
Tópico(s): Metabolism, Diabetes, and Cancer
2021 - Elsevier BV | Molecular Cell
Brian S. Mantilla, Leticia D. Do Amaral, Henning J. Jessen, Roberto Docampo,
Inositol phosphates (IPs) are phosphorylated derivatives of myo-inositol involved in the regulation of several cellular processes ... to mass spectrometry (LC-MS) to dissect the inositol phosphate biosynthetic pathway and its metabolic intermediates in ... of the presence of highly phosphorylated IPs, like inositol hexakisphosphate (IP6), inositol heptakisphosphate (IP7), and inositol octakisphosphate (IP8), that were not detected before by HPLC analyses of the products of radiolabeled exogenous inositol. The kinases involved in their synthesis (inositol polyphosphate ...
Tópico(s): Research on Leishmaniasis Studies
2021 - American Chemical Society | ACS Chemical Biology
Reyna Murry, Lea Traxler, Jessica Pötschner, Thomas Krüger, Olaf Kniemeyer, Katrin Krause, Erika Kothe,
... to regulate development and cellular functions. In fungi, inositol phosphate signaling has been shown to be involved ... are lacking so far. In Schizophyllum commune, an inositol monophosphatase has been found up-regulated during sexual development. The enzyme is crucial for inositol cycling, where it catalyzes the last step of inositol phosphate metabolism, restoring the inositol pool from the monophosphorylated inositol monophosphate. We overexpressed the gene in this model ... were evidenced by proteome analyses. In addition, altered inositol signaling was shown to be involved in tolerance ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2021 - Multidisciplinary Digital Publishing Institute | Journal of Fungi
Debabrata Laha, Marília Kamleitner, Philipp Johnen, Gabriel Schaaf,
The phosphate esters of myo-inositol (Ins) occur ubiquitously in biology. These molecules exist as soluble or membrane-resident derivatives and regulate a plethora of cellular functions ... directed growth, and membrane morphogenesis. Phosphorylation of all inositol hydroxyl groups generates phytic acid (InsP6), the most abundant inositol phosphate present in eukaryotic cells. However, phytic acid is not the most highly phosphorylated naturally occurring inositol phosphate. Specialized small molecule kinases catalyze the formation ...
Tópico(s): Trace Elements in Health
2021 - Springer Science+Business Media | Methods in molecular biology
Paulína Káňovičová, Petra Čermáková, Dominika Kubalová, Lenka Bábelová, Petra Veselá, Martin Valachovič, Jakub Zahumenský, Anton Horváth, J Malínský, Mária Balážová,
... biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces ... biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces ... other effects, VPA inhibits de novo synthesis of inositol from glucose-6-phosphate by indirectly blocking myo-inositol phosphate synthase (19Yu W. Daniel J. Mehta D. ... L. MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition ...
Tópico(s): Genetic Neurodegenerative Diseases
2021 - Elsevier BV | Journal of Biological Chemistry
Ali S. Sharif, Cecilia D. Gerstner, Martha A. Cady, Vadim Y. Arshavsky, Christina A. Mitchell, Guoxin Ying, Jeanne M. Frederick, Wolfgang Baehr,
... and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.J. Biol. Chem. 2000; 275: ... A. Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. ... S.E. Dyson J.M. Mitchell C.A. Inositol polyphosphate 5-phosphatases; new players in the regulation ... Boltshauser E. et al.Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.Nat. Genet. 2009; 41: ...
Tópico(s): Microtubule and mitosis dynamics
2021 - Elsevier BV | Journal of Biological Chemistry