... Rokumeikan by Request of Minister of Foreign Affairs Inoue Kaoru, the Hotel Was a Neo-Renaissance-Style Building ...
0000 - Gale Group | NCCO Photography
Keiji Oguma, Yukako Fujinaga, Kaoru Inoue,
... JapanSearch for more papers by this authorKaoru Inoue, Kaoru Inoue Department of Bacteriology, Okayama University Medical School, Okayama, ... JapanSearch for more papers by this authorKaoru Inoue, Kaoru Inoue Department of Bacteriology, Okayama University Medical School, Okayama, ...
Tópico(s): Neurological disorders and treatments
1995 - Wiley | Microbiology and Immunology
H. Masato, Toshinobu Matsuno, Kaoru Inoue Kaoru Inoue,
We report on the lattice-mismatched growth and electrical properties of In 0.5 Ga 0.5 As/InAlAs modulation-doped heterostructures on GaAs substrates by molecular beam epitaxy using a wide-gap InAlAs graded buffer layer and low-temperature Molecular Beam Epitaxial growth at about 350°C. A drastic reduction in residual carrier accumulation has been achieved, and a high electron mobility at room temperature of 11100 cm 2 /V·s was obtained with an electron concentration of 3×10 12 /cm 2 . It was found that ...
Tópico(s): Semiconductor materials and devices
1991 - Institute of Physics | Japanese Journal of Applied Physics
Keiji Oguma, Kaoru Inoue, Yukako Fujinaga, Kenji Yokota, Takayuki Watanabe, Tohru Ohyama, Koichi Takeshi, Kaoru Inoue,
AbstractClostridium botulinum strains produce seven immunologically distinct neurotoxins (NTX), type A to G. the NTXs associate with nontoxic components in cultures, and become large complexes with three forms (12S, 16S, and 19S) designated progenitor toxins. the 12S toxin consists of a NTX and a nontoxic component having no hemagglutinin (HA) activity (described here as non-toxic non-HA, NTNH), and the 16S and 19S toxins are formed by conjugation of the 12S toxin with HA. Based on the genetic-and protein ...
Tópico(s): Biochemical and Structural Characterization
1999 - Informa | Journal of Toxicology Toxin Reviews
Kaoru Inoue, Yukako Fujinaga, Tatsuo Watanabe, Tohru Ohyama, Koichi Takeshi, Kohji Moriishi, Hiroshi Nakajima, Kaoru Inoue, Keiji Oguma,
The molecular composition of progenitor toxins produced by a Clostridium botulinum type A strain (A-NIH) was analyzed. The strain produced three types of progenitor toxins (19 S, 16 S, and 12 S) as reported previously. Purified 19 S and 16 S toxins demonstrated the same banding profiles on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), indicating that they consist of the same protein components. The nontoxic components of the 19 S and 16 S toxins are a nontoxic non-hemagglutinin ( ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
1996 - American Society for Microbiology | Infection and Immunity
Yoshiro Inoue, Kaoru Inoue, Toshio Terashima, Katsuhiko Mikoshiba, Yasuzo Tsukada,
Tópico(s): Alzheimer's disease research and treatments
1983 - Springer Science+Business Media | Anatomy and Embryology
Toshio Terashima, Yoshiro Inoue, Kaoru Inoue, Katsuhiko Mikoshiba, Yasuzo Tsukada,
Abstract Reeler, a recessive mutation in mice., causes cytoarchitectqnic abnormalities to the cerebral and cerebellar cortices. In normal controls corticospinal (CS) tract neurons retrogradely labelled after HRP injection into the lumbar cord were situated only in layer V (the inner pyramidal layer). In the reeler, by contrast, the labelled CS neurons were scattered diffusely throughout all levels of the corresponding cortical area. In addition to the malpositioning of the somata, the labelled CS ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
1983 - Wiley | The Journal of Comparative Neurology
Karen E. Swales, Satoru Kakizaki, Yukio Yamamoto, Kaoru Inoue, Kaoru Kobayashi, Masahiko Negishi,
The constitutive active receptor (CAR) regulates the induction of the cytochrome P450 2B6 (CYP2B6) gene by phenobarbital-type inducers, such as 1,4 bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) via the distal phenobarbital-responsive enhancer module (PBREM, at –1732/–1685 bp). Activation of the PBREM by TCPOBOP generated a 10-fold induction of CYP2B6 mRNA in HepG2 cells stably expressing mouse CAR (Ym17). Co-treatment with the protein phosphatase inhibitor okadaic acid (OA) synergistically increased ...
Tópico(s): Estrogen and related hormone effects
2004 - Elsevier BV | Journal of Biological Chemistry
Yoshiro Inoue, Yuko Matsumura, Kaoru Inoue, Ryoichi Ichikawa, Chitoshi Takayama,
The 'Wriggle Mouse Sagami (WMS)' is a new neurological mutant with severe dystonic movements of the trunk and extremities whose pathological characters are transmitted by an autosomal recessive gene (wri). Manifestations first appear at 10 days to 2 weeks after birth and progress until 12 weeks of age. In spite of the severe dystonic movements, no marked abnormalities had been found in the cyto- or myeloarchitecture of the central nervous system or that of the peripheral nerves, except for the impaired ...
Tópico(s): Genetic Neurodegenerative Diseases
1993 - Elsevier BV | Neuroscience Research
Masashi Takahashi, Kaoru Inoue, Naoki Koyama, Midori Yoshida, Kaoru Irie, Tomomi Morikawa, Makoto Shibutani, Masamitsu Honma, Akiyoshi Nishikawa,
Tópico(s): Nephrotoxicity and Medicinal Plants
2011 - Springer Science+Business Media | Archives of Toxicology
Kei Tamura, Kaoru Inoue, Masashi Takahashi, Saori Matsuo, Kaoru Irie, Yukio Kodama, Shogo Ozawa, Akiyoshi Nishikawa, Midori Yoshida,
To clarify the dose-response relationship between constitutive androstane receptor (CAR) activity and induction of cytochrome P450 2B (CYP2B) expression and hypertrophy by triazole fungicides in mouse liver, three dose levels of cyproconazole (Cypro), tebuconazole (Teb), fluconazole (Flu), and phenobarbital (PB), a typical CYP2B inducer, were administrated in diet to male wild-type (WT) and CAR-knockout (CARKO) mice for one week. In WT mice, all compounds dose-dependently induced liver weight increases ...
Tópico(s): Pesticide Residue Analysis and Safety
2013 - Elsevier BV | Toxicology Letters
Kei Tamura, Kaoru Inoue, Masashi Takahashi, Saori Matsuo, Kaoru Irie, Yukio Kodama, Toshie Gamo, Shogo Ozawa, Midori Yoshida,
We clarified the involvement of constitutive androstane receptor (CAR) in triazole-induced liver hypertrophy and tumorigenesis using CAR-knockout (CARKO) mice. Seven-week-old male CARKO and wild-type (WT) mice were treated with 200 ppm cyproconazole (Cypro), 1500 ppm tebuconazole (Teb), or 200 ppm fluconazole (Flu) in the diet for 27 weeks after initiation by diethylnitrosamine (DEN). At weeks 4 (without DEN) and 13 (with DEN), WT mice in all treatment groups and CARKO mice in Teb group revealed liver hypertrophy ...
Tópico(s): Inflammatory mediators and NSAID effects
2015 - Elsevier BV | Food and Chemical Toxicology
Yoshiro Inoue, Nobuaki Maeda, Takehiko Kokubun, Chitoshi Takayama, Kaoru Inoue, Toshio Terashima, Katsuhiko Mikoshiba,
P400 protein, which is identical to the inositol 1,4,5-trisphosphate receptor protein, is a glycoprotein closely associated with the membranes of Purkinje cells. Three types of monoclonal antibodies against P400 protein were employed for the immunohistochemical detection of Purkinje cells in the cerebellum and brainstem of the normal and reeler mouse. Purkinje cells in both types of mice were immunoreactive against anti-P400 antibodies, and the soma, dendrites, axon and even terminal boutons in ...
Tópico(s): Vestibular and auditory disorders
1990 - Elsevier BV | Neuroscience Research
Hisako Fushimi, Toru Inoue, Yuya Yamada, Hiroaki Horie, Masakuni Kameyama, Kaoru Inoue, Takeshi Minami, Yuko Okazaki,
Streptozotocin diabetic rats showed an increase of bone fragility (11.9 +/- 2.1 kg/cm2 vs. 16.8 +/- 2.0, P < 0.005) which was normalized by insulin treatment (18.3 +/- 4.2), indicating that osteoporosis was induced in diabetic rats. The rats were fed a zinc-deficient diet (0.16 mg/100 g) or a control diet (5.2 mg/100 g). This mild zinc-deficient diet did not lower the serum zinc level. The cortical bone of diabetic rats was shown to be markedly thinner by microscopic examination of ground cross-sections of the tibia. ...
Tópico(s): Bone and Joint Diseases
1993 - Elsevier BV | Diabetes Research and Clinical Practice
Kaoru Inoue, Akitaka Hisatomi, Fumio Umeda, Hajime Nawata,
Tópico(s): Alzheimer's disease research and treatments
1990 - Elsevier BV | Diabetes Research and Clinical Practice
Toshio Terashima, Kaoru Inoue, Yoshiro Inoue, Katsuhiko Mikoshiba,
Abstract Reeler, an autosomal recessive mutation in mice, causes cytoarchitectonic abnormalities of the cerebral cortex, which are characterized by malposition of neurons. Retrograde and anterograde transport of horseradish peroxidase (HRP) was employed to examine the reciprocal connectivity between the hindlimb area of the primary motor cortex (MI) and thalamus of normal and reeler mutant mice. In the normal mouse, most of the cells labelled after HRP injection into the hindlimb area of MI were located ...
Tópico(s): Zebrafish Biomedical Research Applications
1987 - Wiley | The Journal of Comparative Neurology
Akiyoshi TAMURA, Takeshi Uenoyama, K. Nishii, Kaoru Inoue, Takeshi Onuma,
A new rapid thermal annealing (RTA) method that uses GaAs guard rings has been developed. A new temperature monitoring method is also described. Generations of slip lines on 2-in.-diam GaAs wafers annealed in different kinds of RTA arrangements were investigated by x-ray transmission topography. The use of three GaAs guard rings has been found to be very effective in reducing slip lines. The temperature dependence of activation and uniformity of annealing characteristics for a selective Si-implanted ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
1987 - American Institute of Physics | Journal of Applied Physics
Hidekuni Takahagi, Kaoru Inoue, Masaaki HORIGUCHI,
A procedure involving direct injection of whole plasma for analyses of drugs by an automated high-performance liquid chromatograph was developed. This system comprised two columns, two pumps, one detector, two programmable switching valves, an automatic sample injector with a cooling device for sample tubes and a microprocessor. Effluents from the first column, containing a drug of interest, were selectively introduced into the second column for further separation. The columns used were an aqueous ...
Tópico(s): Chemical Synthesis and Analysis
1986 - Elsevier BV | Journal of Chromatography A
Toshio Terashima, Kaoru Inoue, Yoshiro Inoue, Minesuke Yokoyama, Katsuhiko Mikoshiba,
Abstract The normal‐reeler chimera mouse (+/+ ↔ rl/rl) provides an experimental system in which an analysis of the migration of immature neurons in the cerebellum can be accomplished. In the present study, five chimera mice were produced from embryos of the wild‐type control (C57Bl/6N) and the reeler mutant mouse (BALB/c) by the aggregation technique. The isozyme pattern of glucosephosphate isomerase (GPI) revealed that the brain tissue in the chimera contained both isozymes of the BALB/c (reeler) and C57Bl/ ...
Tópico(s): Neuroscience and Neuropharmacology Research
1986 - Wiley | The Journal of Comparative Neurology
Jean‐Christophe Harmand, Toshinobu Matsuno, Kaoru Inoue,
We report on the lattice-mismatched growth of In 0.53 Ga 0.47 As/In 0.52 Al 0.48 As modulation-doped heterostructures on GaAs substrates by molecular beam epitaxy. A buffer layer structure and its growth conditions were optimized. As a result, we obtained a sample with a mirrorlike surface which exhibits electron mobility of 10500 cm 2 /V·s and 48500 cm 2 /V·s at 300 K and 77 K, respectively. These values are comparable to those obtained in lattice-matched structures grown on InP substrates. To our ...
Tópico(s): Cold Atom Physics and Bose-Einstein Condensates
1989 - Institute of Physics | Japanese Journal of Applied Physics
Hitoshi Sohma, Kaoru Inoue, Fumi Morita,
A cAMP-dependent regulatory protein which modulates the phosphorylation of scallop myosin regulatory light chain-a (RLC-a) by RLC-a myosin kinase (aMK) (Sohma, H. & Morita, F. (1986) J. Biochem. 100, 1155-1163) was purified from the scallop smooth muscle. RLC-a is abundant in the opaque portion of scallop smooth muscle, one of the catch muscles. The regulatory protein for aMK was purified by employing successively DEAE Toyopearl ion exchange chromatography, Sepharose 4B-8(6-aminohexylamino)cAMP affinity ...
Tópico(s): Cardiomyopathy and Myosin Studies
1988 - Oxford University Press | The Journal of Biochemistry
Kaoru Inoue, Midori Yoshida, Masashi Takahashi, Hitoshi Fujimoto, K. OHNISHI, Koichi Nakashima, Makoto Shibutani, Masao Hirose, Akiyoshi Nishikawa,
Madder color (MC) has been shown to exert carcinogenic potential in the rat kidney in association with degeneration, karyomegaly, increased cell proliferation of renal tubule cells and increased renal 8-OHdG levels. To clarify the causal relationship of components and metabolites of MC to renal carcinogenesis, male F344 rats were fed lucidin-3-O-primeveroside (LuP) or alizarin (Alz), and the genotoxic LuP metabolites lucidin (Luc) or rubiadin (Rub) for up to 26 weeks. After one week and four weeks, Luc ...
Tópico(s): Skin Protection and Aging
2009 - Elsevier BV | Food and Chemical Toxicology
Shingo Mutoh, Makoto Osabe, Kaoru Inoue, Rick Moore, L. G. Pedersen, L. Perera, Yvette Rebolloso, Tatsuya Sueyoshi, Masahiko Negishi,
Upon activation by therapeutics, the nuclear xenobiotic/ constitutive active/androstane receptor (CAR) regulates various liver functions ranging from drug metabolism and excretion to energy metabolism. CAR can also be a risk factor for developing liver diseases such as hepatocellular carcinoma. Here we have characterized the conserved threonine 38 of human CAR as the primary residue that regulates nuclear translocation and activation of CAR. Protein kinase C phosphorylates threonine 38 located on ...
Tópico(s): Estrogen and related hormone effects
2009 - Elsevier BV | Journal of Biological Chemistry
Yukie Saegusa, Hitoshi Fujimoto, Gye‐Hyeong Woo, Kaoru Inoue, Masashi Takahashi, Kunitoshi Mitsumori, Masao Hirose, Akiyoshi Nishikawa, Makoto Shibutani,
To evaluate developmental exposure effects of two brominated flame retardants, tetrabromobisphenol A (TBBPA) and 1,2,5,6,9,10-hexabromocyclododecane (HBCD), pregnant Sprague-Dawley rats were administered either chemical at doses of 100, 1000 or 10,000 ppm in a soy-free diet from gestation day 10 until the day 20 after delivery. Offspring exposed to TBBPA showed dose-unrelated slight decreases of serum triiodothyronine (T(3)) concentration at postnatal day 20, and there was no evidence of hypothyroidism- ...
Tópico(s): Air Quality and Health Impacts
2009 - Elsevier BV | Reproductive Toxicology
Kaoru Inoue, Masahiko Negishi,
Nuclear xenobiotic receptor CAR activates transcription of the CYP2B6 gene by directly binding to the distal enhancer PB responsive enhancer module (PBREM). This CAR-mediated activation is synergized by transcription factors early growth response 1 (EGR1) and hepatocyte-enriched nuclear factor 4alpha (HNF4alpha) that bind to the proximal element OA response element KI (OARE(KI)) [Inoue, K., & Negishi, M. (2008). Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 ...
Tópico(s): Drug Transport and Resistance Mechanisms
2009 - Wiley | FEBS Letters
Toshiji Kato, Kaoru Inoue, Takayuki Fukutani, Yoshinori Kanda,
Various fast and efficient computation techniques for a power converter simulation have been researched. According to the conventional methods, a single step size for a whole circuit is selected for the numerical integration. A real-power electronic system, however, is multirate in that its currents and voltages nonuniformly vary spatially and temporally, and its subcircuits have different transient rates. A simulation that selected an appropriate step size for each subcircuit independently would, ...
Tópico(s): Electromagnetic Compatibility and Noise Suppression
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Kaoru Inoue, Midori Yoshida, Masashi Takahashi, Hitoshi Fujimoto, Makoto Shibutani, Masao Hirose, Akiyoshi Nishikawa,
Madder color (MC), a food coloring extracted from roots of Rubia tinctorum L., has been proven to exert carcinogenicity in the rat kidney and liver. Furthermore, it induces DNA adducts in the kidney, liver, and colon. MC is in fact composed of anthraquinones such as lucidin-3-O-primeveroside and alizarin. To clarify which of these might be responsible for the carcinogenicity, a rat medium-term multi-organ carcinogenesis bioassay was performed focusing on the kidney, liver, and colon. Male 6-week- ...
Tópico(s): Dye analysis and toxicity
2009 - Wiley | Cancer Science
Masashi Takahashi, Makoto Shibutani, Jun Nakahigashi, Natsumi Sakaguchi, Kaoru Inoue, Tomomi Morikawa, Midori Yoshida, Akiyoshi Nishikawa,
Tópico(s): Potato Plant Research
2009 - Springer Science+Business Media | Archives of Toxicology
Makoto Shibutani, Gye‐Hyeong Woo, Hitoshi Fujimoto, Yukie Saegusa, Masashi Takahashi, Kaoru Inoue, Masao Hirose, Akiyoshi Nishikawa,
To clarify the developmental effects of hypothyroidism and to establish a detection system of resultant brain retardation, pregnant rats were administered 3 or 12 ppm of 6-propyl-2-thiouracil (PTU) or 200 ppm of methimazole (MMI) in the drinking water from gestation day 10 to postnatal day 20 and maintained after weaning until 11 weeks of age (adult stage). Offspring displayed evidence of growth retardation lasting into the adult stage, which was particularly prominent in males. Except for hypothyroidism- ...
Tópico(s): Pregnancy and preeclampsia studies
2009 - Elsevier BV | Reproductive Toxicology
Kaoru Inoue, Akitaka Hisatomi, Fumio Umeda, Hajime Nawata,
Amylin is a 37-amino acid peptide isolated from the islet amyloid of patients with non-insulin-dependent diabetes mellitus. The isolated perfused normal rat pancreas was used to evaluate the effects of glucose and insulin secretagogues, such as arginine, beta-hydroxybutyrate, and gliclazide, on amylin secretion. Glucose and the other stimulants tested elicited a significant release of amylin from the rat pancreas in a biphasic pattern, similar to that of insulin. Dose-response studies of the glucose- ...
Tópico(s): Diabetes Treatment and Management
1991 - American Diabetes Association | Diabetes