... organic chemist. It is thus surprising that the intramolecular version, in which both diene and dienophile are ... of complex polycyclic molecules only recently. In the intramolecular Diels–Alder reaction, two rings are formed in ... reflected in large negative activation entropies. In the intramolecular version, some of the ordering has been accomplished ... using forcing conditions one can sometimes carry out intramolecular Diels–Alder additions that would be doomed to ... the bimolecular Diels–Alder reaction interferes with the intramolecular cyclization are rare. All of these features suggest ...
Tópico(s): Chemical Synthesis and Analysis
1984 - American Chemical Society | Organic reactions
Wonjang Jeong, Mi Jung Kim, Hyoungsu Kim, Sanghee Kim, Deukjoon Kim, Kye Jung Shin,
... cis- or α,α′-trans-tetrahydrofuran isomers by intramolecular alkylation with either an amide enolate or a ... a striking difference in the stereochemistry of the intramolecular alkylation involving either an N,N-dimethylamide enolate ... be constructed in a stereoselective manner through an intramolecular amide enolate alkylation (IAEA) of tosylate 6, which ... three steps) with 17:1 syn/anti selectivity. Intramolecular amide enolate alkylation and RCM: a) CH2=CHCH2MgCl, ... this end, 8 was transformed into the key intramolecular alkylation substrate 17 by a straightforward four-step ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2009 - Wiley | Angewandte Chemie International Edition
Rhonda A. Newman, Kenneth E. Prehoda,
... regions of the membrane. Allosteric regulation of an intramolecular interaction between the Src homology 3 (SH3) and ... encodes a form of Dlg that disrupts the intramolecular association while leaving the SH3 and GK domains ... to assess the role of the SH3-GK intramolecular interaction in MAGUK function. Analysis of asymmetric cell ... maternal-zygotic dlgsw embryonic neuroblasts demonstrates that the intramolecular interaction is not required for Dlg localization but ... conclude that allosteric regulation of the SH3-GK intramolecular interaction is required for regulation of MAGUK function ...
Tópico(s): Cellular Mechanics and Interactions
2009 - Elsevier BV | Journal of Biological Chemistry
Marcus Gutscher, Mirko C. Sobotta, Guido H. Wabnitz, Seda Ballikaya, Andreas J. Meyer, Yvonne Samstag, Tobias P. Dick,
... resolving cysteine of Orp1 (Cys82) to generate an intramolecular disulfide bond that is subject to reduction by ... of Yap1 and thus exchanged into a Yap1 intramolecular disulfide bond. The disulfide form of Yap1 accumulates ... disulfide, which is then rearranged into a target intramolecular disulfide by virtue of a second target thiol. ... formed Cys36-SOH is rapidly converted into the intramolecular Cys36–Cys82 disulfide bond (16.Ma L.H. ... the absence of Cys82 demonstrates that the Orp1 intramolecular disulfide is dispensable for Yap1 oxidation (14.Delaunay ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2009 - Elsevier BV | Journal of Biological Chemistry
... functional theory method was performed to investigate the intramolecular and intermolecular hydrogen bonding in both the singlet ... such as internal conversion, intersystem crossing (ISC), twisted intramolecular charge transfer (TICT), and so forth. The intramolecular hydrogen bond C=O...H-N can be ... for the isolated AF and MAF. However, no intramolecular hydrogen bond for DMAF can be formed. At ... and 41.74 degrees, respectively. The formation of intramolecular hydrogen bond for AF and MAF is tightly ... can be dominantly determined by the change of intramolecular hydrogen bond between S(1) and T(1) ...
Tópico(s): Radical Photochemical Reactions
2009 - American Chemical Society | The Journal of Physical Chemistry A
Alexander Wulf, Koichi Fumino, Ralf Ludwig, Philip F. Taday,
... above 150 cm−1 can be assigned to intramolecular bending and wagging modes of cations and anions ... anions. However, uncertainties remained as to whether all intramolecular vibrational modes above 120 cm−1 are attributed ... methods are differently suitable for detecting intermolecular and intramolecular vibrational modes. The given combination allows the assignment ... 170 cm−1 can be referred to the intramolecular bending mode of the N(CN)2− anion. ... for [C2mim][SCN] and [C2mim][EtSO4] no significant intramolecular vibrational modes of the anions can be detected ...
Tópico(s): Acoustic Wave Resonator Technologies
2009 - Wiley | ChemPhysChem
Marie‐Ève Charbonneau, Julie Janvore, Michaël Mourez,
... we confirmed that cleavage of AIDA-I is intramolecular. Our results unveil a new mechanism of auto- ... we confirmed that cleavage of AIDA-I is intramolecular. Our results unveil a new mechanism of auto- ... the mechanism of proteolysis for AIDA-I is intramolecular. This is the first report of this type ... the cleavage of AIDA-I relies on an intramolecular mechanism of processing.As shown in Fig. 9, ... model also differs from the two previously described intramolecular mechanisms of cleavage for autotransporters; that is, the ...
Tópico(s): Escherichia coli research studies
2009 - Elsevier BV | Journal of Biological Chemistry
Min Chen, Aaron Orozco, David M. Spencer, Jin Wang,
... inefficient in the dimer in the absence of intramolecular processing, suggesting that caspase activation is initiated via intramolecular processing. Homodimerization of caspase-8 or caspase-9 ... inefficient in the dimer in the absence of intramolecular processing, suggesting that caspase activation is initiated via intramolecular processing. Homodimerization of caspase-8 or caspase-9 ... in the oligomer may cleave itself by an intramolecular processing mechanism. In this study, we provide evidence ... stable dimeric intermediate induces caspase activation by an intramolecular processing mechanism. A synthetic rapamycin analog, AP20840 (Ariad ...
Tópico(s): Autophagy in Disease and Therapy
2002 - Elsevier BV | Journal of Biological Chemistry
Марек Напиерала, Paweł Parniewski, Anna Pluciennik, Robert D. Wells,
... sequences using a genetic assay based on an intramolecular plasmid system in Escherichia coli. The rate of intramolecular recombination between long CTG·CAG tracts oriented as ... implies the involvement of DNA replication in the intramolecular recombination between CTG·CAG sequences. Thus, long CTG· ... sequences using a genetic assay based on an intramolecular plasmid system in Escherichia coli. The rate of intramolecular recombination between long CTG·CAG tracts oriented as ... implies the involvement of DNA replication in the intramolecular recombination between CTG·CAG sequences. Thus, long CTG· ...
Tópico(s): Fungal and yeast genetics research
2002 - Elsevier BV | Journal of Biological Chemistry
Ervin Welker, Lynne D. Raymond, Harold A. Scheraga, Byron Caughey,
... have suggested that the presence of this sole intramolecular disulfide bond in PrPsen is required for conversion ... bonds in PrPres are intermolecular (between monomers) or intramolecular (within monomers) is a critical issue that has ... that, upon denaturation, PrP monomers with an intact (intramolecular) disulfide bond dissociate from an infectious PrPrespreparation (14Turk ... by sequestering the disulfide bond(s) from the intramolecular attack by the thiol(s). However, when the ... the thiol of another cysteine residue. This fast intramolecular reshuffling persists in the unfolded protein, resulting in ...
Tópico(s): Porphyrin Metabolism and Disorders
2002 - Elsevier BV | Journal of Biological Chemistry
Christophe Blanchetot, Leon G.J. Tertoolen, John Overvoorde, Jeroen den Hertog,
... Chem. 2000; 275: 12446-12452Google Scholar). Inter- and intramolecular interactions between purified CD45-D1 and CD45-D2 ... of RPTPμ was shown to bind in an intramolecular fashion with both PTP domains of RPTPμ, thus ... and LAR-D2, provided some structural evidence for intramolecular D1/D2 binding (5Nam H.J. Poy F. ... with LAR-D2 through the spacer region. Using intramolecular FRET, the conformation of RPTPα-D2 was found ... These results are consistent with the model that intramolecular D1/D2 binding regulates intermolecular D1/D2 interactions. ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2002 - Elsevier BV | Journal of Biological Chemistry
Melissa Schwaller, Bonney Wilkinson, Hiram Gilbert,
... cycles of reduction and reoxidation in preference to intramolecular isomerization of the PDI-bound substrate. Using a ... reoxidation may set up critical folding intermediates for intramolecular isomerization, or it may serve as the only ... cycles of reduction and reoxidation in preference to intramolecular isomerization of the PDI-bound substrate. Using a ... reoxidation may set up critical folding intermediates for intramolecular isomerization, or it may serve as the only ... disulfide, resulting in a different disulfide configuration. The intramolecular rearrangement concludes when a substrate cysteine displaces PDI ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2003 - Elsevier BV | Journal of Biological Chemistry
Olivier David, Wim J. N. Meester, Hans Bieräugel, Hans E. Schoemaker, Henk Hiemstra, Jan H. van Maarseveen,
... closure by traditional strategies is enabled by an intramolecular Staudinger ligation approach. An undesired premature Staudinger reaction ... reactions. Herein we show the power of the intramolecular Staudinger ligation method (Scheme 1), which provides access ... 9-membered lactams including the monocyclic homodiketopiperazine series. Intramolecular Staudinger ligation. Ligation strategies have been developed to ... reaction12 produces an intermediate iminophosphorane, which undergoes an intramolecular S→N acyl-transfer reaction via a favored ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2003 - Wiley | Angewandte Chemie International Edition
Akimasa Matsugami, T. Okuizumi, Seiichi Uesugi, Masato Katahira,
... physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a similar architecture to that of the intramolecular parallel quadruplex was found for a telomere DNA ... GGA)8 (24-mer) under physiological conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G ... manner. This is the first demonstration of the intramolecular higher order packing of quadruplexes at atomic resolution. ... physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2003 - Elsevier BV | Journal of Biological Chemistry
Noriyuki Asaba, Toshihiko Hanada, Atsuko Takeuchi, Athar H. Chishti,
... binding of GAKIN is not regulated by the intramolecular interactions within the discs large protein. The recombinant ... binding of GAKIN is not regulated by the intramolecular interactions within the discs large protein. The recombinant ... revealed the existence of a novel mode of intramolecular interactions between the SH3 and GUK domains, providing ... of SAP97 is regulated by a series of intramolecular interactions between the SH3 and GUK domains (33Wu ... GUK domain of hDlg is not regulated by intramolecular interactions of the SH3 and GUK domains (Fig. ...
Tópico(s): Cellular Mechanics and Interactions
2003 - Elsevier BV | Journal of Biological Chemistry
Yoshiyuki Nishimiya, Satoru Ohgiya, Sakae Tsuda,
... pout (Lycodichthys dearborni) comprises the type III AFP intramolecular dimer, which is known to exhibit a significant ... Chem. 276, 1304–1310). Here we genetically synthesized intramolecular dimer, trimer, and tetramer of the type III ... pout (Lycodichthys dearborni) comprises the type III AFP intramolecular dimer, which is known to exhibit a significant ... Chem. 276, 1304–1310). Here we genetically synthesized intramolecular dimer, trimer, and tetramer of the type III ... AFP, antifreeze protein; RD3, native type III AFP intramolecular dimer comprising the N- and C-domains connected ...
Tópico(s): Neurobiology and Insect Physiology Research
2003 - Elsevier BV | Journal of Biological Chemistry
Jongchul Yoon, Bora Oh, Kyunggon Kim, Jungeun Park, Dohyun Han, Kyeong Kyu Kim, Sun‐Shin Cha, Dongsoon Lee, Youngsoo Kim,
... enzyme with α- and β-subunits, first by intramolecular cleavage and, second, by intermolecular cleavage. Intramolecular autocatalytic proteolysis is initiated by nucleophilic attack of ... study determined the precursor structure after disabling the intramolecular cleavage. This study also provides experimental evidence showing ... the Ser-1β to a target carbonyl carbon. Intramolecular proteolysis is disabled as a result of a ... water molecule plays a critical role in initiating intramolecular cleavage in the post-translational modification of the ...
Tópico(s): Cancer-related gene regulation
2003 - Elsevier BV | Journal of Biological Chemistry
Noemí Blanco-García, Elena Asensio-Juan, Xavier de la Cruz, Marian A. Martínez‐Balbás,
... p300 in vivo. P/CAF autoacetylation is an intramolecular or intermolecular event. Intramolecular acetylation targets five lysines within the nuclear localization ... subcellular distribution of P/CAF is regulated by intramolecular autoacetylation and found that a P/CAF mutant ... p300 in vivo. P/CAF autoacetylation is an intramolecular or intermolecular event. Intramolecular acetylation targets five lysines within the nuclear localization ... subcellular distribution of P/CAF is regulated by intramolecular autoacetylation and found that a P/CAF mutant ...
Tópico(s): Sirtuins and Resveratrol in Medicine
2008 - Elsevier BV | Journal of Biological Chemistry
Nancy W. Karuri, Zong Lin, Hays S. Rye, Jean E. Schwarzbauer,
... and by treatment with mild denaturants that disrupted intramolecular interactions between the two modules. We also show ... and by treatment with mild denaturants that disrupted intramolecular interactions between the two modules. We also show ... conformational sensor designed to test the idea that intramolecular interactions between III1 and III2 sequester key FN- ... modules to interact. As proposed by our model, intramolecular interactions give III1–2 a compact conformation within ... from CFP and YFP in the CIIIY spectrum. Intramolecular FRET in CIIIY—Fluorescence spectroscopy studies of CIIIY ...
Tópico(s): Cellular Mechanics and Interactions
2008 - Elsevier BV | Journal of Biological Chemistry
Ryu Takeya, K Taniguchi, Shuh Narumiya, Hideki Sumimoto,
... major endothelial formin that is normally autoinhibited by intramolecular interaction between the N- and C-terminal regions. ... Bni1p, are likely to be inhibited through an intramolecular interaction between the C-terminal Dia autoregulatory domain ( ... in an inactive form through a DAD-mediated intramolecular interaction with the N-terminal region (Gasteier et ... appears to be sufficient for disruption of the intramolecular interaction in FHOD1. Furthermore, expression of a full- ... S2A). We next tested the effect of the intramolecular interaction of FHOD1 on phosphorylation by ROCK. FHOD1- ...
Tópico(s): S100 Proteins and Annexins
2008 - Springer Nature | The EMBO Journal
Brian K. Kobilka, Xavier Deupí,
... intermediate states involves the disruption of non-covalent intramolecular interactions that stabilize the basal state of the ... entail the disruption of different combinations of these intramolecular interactions, leading to different receptor conformations and differential ... View Large Image Figure ViewerDownload (PPT)Non-covalent intramolecular interactions define the activity and stability of the ... be predicted that disrupting one of the stabilizing intramolecular interactions would favor either a more active conformation ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2007 - Elsevier BV | Trends in Pharmacological Sciences
Marcelo G. Kazanietz, Mark A. Lemmon,
... of PKCβII, an AGC kinase, revealing an unanticipated intramolecular autoinhibitory interaction between its C-terminal tail and ... of PKCβII, an AGC kinase, revealing an unanticipated intramolecular autoinhibitory interaction between its C-terminal tail and ... primed” by phosphorylation, PKC isoforms remain “autoinhibited” by intramolecular interactions between the N-terminal pseudosubstrate region and ... be maintained in an inactive state by unexpected intramolecular autoinhibitory interactions between the regulatory C1b domain and ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2011 - Elsevier BV | Structure
Martin Muik, Marc Fahrner, Rainer Schindl, Peter B. Stathopulos, Irene Frischauf, Isabella Derler, Peter Plenk, Barbara Lackner, Klaus Groschner, Mitsuhiko Ikura, Christoph Romanin,
... 2011Open Access STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation Martin Muik Martin ... activating small fragment (OASF) undergoes a C-terminal, intramolecular transition into an extended conformation when activating ORAI1. ... revealing the involvement of hydrophobic residues in the intramolecular transition. Corresponding full-length STIM1 mutants exhibited enhanced ... imitate a physiological activated state, which mimics the intramolecular transition that occurs in native STIM1 upon store ...
Tópico(s): Ion channel regulation and function
2011 - Springer Nature | The EMBO Journal
... GK) protein interaction domains of Dlg, whereas an intramolecular interaction between the two domains inhibits association with ... GK) protein interaction domains of Dlg, whereas an intramolecular interaction between the two domains inhibits association with ... domain. The SH3 and GK domains form an intramolecular interaction in the MAGUK PSD-95, which is ... ion channels and organizing signal transduction pathways. The intramolecular interaction between the SH3 and GK domains is ... related Caenorhabditis elegans lin-2 gene disrupt the intramolecular interaction (5McGee A.W. Bredt D.S. J. ...
Tópico(s): Microtubule and mitosis dynamics
2006 - Elsevier BV | Journal of Biological Chemistry
Liana Oganesian, Ian K. Moon, Tracy M. Bryan, Michael B. Jarstfer,
... recombinant Tetrahymena and native Euplotes telomerase. Inter- and intramolecular G-quadruplexes were gel-purified and their stability ... ciliate telomerases in primer extension assays. In contrast, intramolecular G-quadruplexes formed in K+ exhibited biphasic unfolding ... were not extended by ciliate telomerases. Na+-stabilised intramolecular G-quadruplexes were extended by telomerase owing to ... telomerase protein component bound to inter- but not intramolecular K+-stabilised G-quadruplexes. This study provides evidence ...
Tópico(s): RNA Interference and Gene Delivery
2006 - Springer Nature | The EMBO Journal
Eric A. Appel, Joseph Dyson, Jesús del Barrio, Zarah Walsh, Oren A. Scherman,
... nanoparticles were prepared through stimuli-responsive and reversible intramolecular crosslinking of a single polymer chain in water. ... 2 In this instance, crosslinking must be specifically intramolecular to form these "self-collapsed" single-chain polymeric ... dilaurate, NMP=N-methylpyrrolidone, rt=room temperature). Controlled intramolecular collapse of the functional polymer chains was achieved ... the high effective molarity (Meff) typically observed in intramolecular interactions.29 Control experiments were developed whereby multi- ...
Tópico(s): Radioactive element chemistry and processing
2012 - Wiley | Angewandte Chemie International Edition
Christian Lesterlin, Emmanuelle Gigant, Frédéric Boccard, Olivier Espéli,
... carried by the same molecule, i.e., an intramolecular/intrachromatid event (event 1 Figure 1A), was prevented ... arrows). This construct conferred the Lac− phenotype. The intramolecular recombination event (noted 1) was prevented by the ... product (blue arrow), conferring the Lac+ phenotype. The intramolecular recombination between the first and third loxP sites ... were separated by 105 bp and therefore supported intramolecular recombination in vivo (event 3, Figure 1A). Because ... measured for the same loci the capacity of intramolecular loxP/Cre recombination to estimate the relative access ...
Tópico(s): Escherichia coli research studies
2012 - Springer Nature | The EMBO Journal