Ray Goshing, Smokey, John Naughton, William Henry Holmes, Nigel Andrew, Paul De la Sautée, Eric Griffiths, Eric Miswinter, D. A. N. Jones, Nick Clarke, Brendan Callaghan Sj, Ma, MPhil, MTh, Julian Critchley, Naomi Lewis, Barry Took, M. P., Robin Lustig, K. I. Ward SRN, Carl Gardner, Roger Woddis, Robert Harris, Barry Fox, Pamela Smith, Sophy Robinson, Michael Poole, J. Holden, Reginald Lightwood, Cara Chanteau, Patrick Steptoe Frcs, Frcog, Julian O'Halloran, Peter Fiddick, Stephen Spender, Mary Goldring, Richard Morrison, John Cole, C. R. Austin, Irene Watson Hon. Secretary, Angela Huth, Julie Sheppard, Peter Lennon, Lewis Foreman, Margaret Percy, Colin Shaw, M. Whitehouse, David Murray,
The Listener NP The Listener The case of the confused chemicals The only substantial piece of evidence has now been completely discredited The Listener ...
1983 - Gale Group | The Listener GDA
Cara Dosman, Irene Drmic, Jessica Brian, Ambikaipakan Senthilselvan, Mary Harford, Ryan Smith, S Wendy,
... ferritin concentration' Cara F Dosman MD, Corresponding Author Cara F Dosman MD aGlenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta;*Correspondence to: carado123 @hotmail. ComSearch for more papers by this authorIrene E Drmic MSc, Irene E Drmic MSc bDepartment of Psychology, York University; ... this author Cara F Dosman MD, Corresponding Author Cara F Dosman MD aGlenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta;*Correspondence to: carado123 @hotmail. ComSearch for more papers by this authorIrene E Drmic MSc, Irene E Drmic MSc bDepartment of Psychology, York University; ...
Tópico(s): Child Nutrition and Feeding Issues
2006 - Wiley | Developmental Medicine & Child Neurology
Leni Gillman, Edward Helmore, Michael Prescott, Pete Bradley, Rhoda Koenig, Barbara Hall, Rupert Darwall, Richard Ellis, Peter McKay, Shena MacKay, Jon Swain, Helen Davidson, Anthony Clare, John Peter, Pam Barrett, G R Watkin, John Harlow Transport Correspondent, Jonathan Miller, Eric Dymock, Norman MacRae, James Rusbridger, Susan d'Arcy, John Diamond, Frank Whitford, Graham Rose, Gordon Kirby, John Stansell, Diana Wright Personal Finance Editor, J P Emery, Sally Payne, David Smith, Sean Ryan Environment Correspondent, Hermione Lee, Robert Leedham, Nick Pitt, Charles Hymas, Andrew Sullivan, Ivan Falion, Sarah Beattie, Peter West, Francesca Nelson, Caroline Lees Arts Correspondent, Geordie Greig, Tony Allen-Mills, Martin James, Robert Sandall, Iain Johnstone, Nilgin Yusuf, Irwin Stelzer, Peter Wilson, Ivan Fallon, David Dougill, John Mortimer, Clifford Wallis, Patrick Janson-Smith, Malcolm Wheatley, C Bullen, Harvey Porlock, Hugh Canning, Jeremy Clarkson, Peter Kemp, Michael Jones, Sean MacCarthaigh, Peter Kellner, George Perry, Sue Mott, Robin Marlar, Anatole Kaletsky, Nick Gardner, Harry Ritchie, Sir Roy Strong, Shelley von Strunckel, Jonathan Margolis, Maria Cara, Bernard Cafferty, Neville Hodgkinson Science Correspondent, Richard Johnson, Roy Strong, Stuart Wavell, Roger Eglin, Paul Donovan, Steven Wheeler, Frances Spalding, Jeff Randall, James Bethell, Paul Driver, James Adams, Roddy Doyle, Margaret Dibben, R Lindström, Liz Lightfoot, Caroline Scott, Camille Paglia, Irene Lamont, Maurice Bale, Heather Couper, Steel Brownlie, Cathy Galvin, Mark Edwards, Kirstie Hamilton, Rufus Olins, Julian Loose, Martin Jacques, Robert Gahan, George Town, Wade Smith, Phil Baker, Christopher Lloyd, Charles Hymas Education Correspondent, Michael Winner, Lois Rogers, Jenny Diski, Sara Hiorns, Christopher Ward, John Karter, Kate Saunders, Barbara Amiel, Malcolm Winton, Noeline Donaher, Craig Brown, Diana Wright, Peter Bryan, Stephen Jones, Count Paolo Filo Della Torre, Brian Deer, Richard Burgess-Ellis, Peter Blomeley, Richard Palmer, Paul Nuki, Ivan Hill, Martin Searby, Miranda Seymour, Ian Critchley, Anthony Godby Johnson, The Rt Hon Lord Ashley, Andrew Lorenz Associate Business Editor, Tim Willis, Russell Miller, Brough Scott, Bruce Johnston, Parin Janmohamed, Richard Woods, Peter Johnson, Rachel Cooke, Maurice Chittenden, Iola Smith, Neil Lyndon, Michael Kallenbach, Dr Mark Griffiths, Jonathon Porritt, Craig Lord, Michael Jones Political Editor, J M Monk, David Hunn, Frank McLynn, D J Taylor, Michael Hanson, Mihir Bose, John Harlow, Dr Philip Welsby, Michael Austin, Alastair Burnet, Emily Dean, Christa D'Souza, Dave Hill, Matthew Campbell, Dr Chris Hails Director, Stan Levenson, Chris Dighton, Steven Berkoff, Alejandro H Rodriguez-Giovo, Lauren St John, Chrissy Iley, Peter, Tom Tickell, Gilbert Adair, Dr David Fisher, Dr Derek Pheby, Andrew Lorenz, John Furbisher, Peter Semler, Cynthia Harrod-Eagles, Claire Rayner, Dean James Potter, Rajmata Vijayaraje Scindia Mp, Joe Lane, John Parker, Jonathan Futrell, Hugh Pearman, Jeff Randall City Editor, Andrew Davidson, John Kohut, David Smith Economics Editor, Kay Ricketts, Penny Perrick, Tony Hetherington, Martin Booth, Peter Roebuck, Joanna Simon, Nicholas Kenyon, Iain Jenkins, Janine di Giovanni, Geoff Thompson, Boris Schapiro,
Treasury tells Clarke: you must raise taxes Lamont aide claims the Tory left is taking over Neo-fascists run Rachman racket Virgin's Angel Row over minister' ...
1993 - Gale Group | Sunday Times HA GDA
Cara Dosman, Irene Drmic, Jessica Brian, Ambikaipakan Senthilselvan, Mary Harford, Ryan Smith, S. Wendy Roberts,
Tópico(s): Iron Metabolism and Disorders
2006 - Wiley | Developmental Medicine & Child Neurology
Emanuele Pivetta, Alberto Goffi, Maria Tizzani, Stefania Locatelli, Giulio Porrino, Isabel Losano, Dario Leone, G Calzolari, Matteo Vesan, Fabio Steri, Arianna Ardito, Marialessia Capuano, Maria Gelardi, Giulia Silvestri, S. Dutto, Maria Avolio, Rossana Cavallo, Alice Bartalucci, Cristina Paglieri, Fulvio Morello, Lorenzo Richiardi, Milena Maule, Enrico Lupia, Federico Baldassa, Paolo Baron, Giordano Bianchi, Valeria Busso, Andrea Conterno, Paola Rizzo, Paolo Fascio Pecetto, Francesca Giachino, Andrea Iannaccone, Patrizia Ferrera, Franco Riccardini, Claudia Sacchi, Michela Sozzi, Silvia Totaro, Pasqualina Visconti, Francesca Risi, Francesca Basile, Denise Baricocchi, Alessia Beux, Valentina Beux, Paolo Bima, Irene Cara, Liliana Chichizola, Francesca Dellavalle, Federico Vilaplana Grosso, Giulia Labarile, Matteo Oddi, Marco Ottino, Ilaria Pia, Virginia Scategni, Astrid Surra,
Study objectiveAccurate diagnostic testing to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical. Although highly specific, SARS-CoV-2 reverse transcriptase–polymerase chain reaction (RT-PCR) has been shown in clinical practice to be affected by a noninsignificant proportion of false-negative results. This study seeks to explore whether the integration of lung ultrasonography with clinical evaluation is associated with increased sensitivity for the diagnosis ...
Tópico(s): Pleural and Pulmonary Diseases
2020 - Elsevier BV | Annals of Emergency Medicine
César Menor, Jesús Fueyo, Óscar Escribano, María Jesús Boné Pina, Pilar Negrete Redondo, C. Cara, Irene D. Román, M.D. Fernández-Moreno, Luis G. Guijarro,
The present study was performed in order to obtain the thiopurine methyltransferase (TPMT) activity frequency distribution histogram in a Spanish population. A total of 3640 Spanish clinical laboratory samples were evaluated, which included 1249 patients with Crohn’s disease, 589 with ulcerative colitis, 348 with multiple sclerosis (MS), 487 with several autoimmune diseases different from the above-mentioned diseases and 967 a donor group. We have measured the TPMT activity in red blood cells (RBCs) ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2002 - SAGE Publishing | Multiple Sclerosis Journal
Cara Pray, Neelufor Irene Feroz, Nisha Nigil Haroon,
Tópico(s): Bone health and osteoporosis research
2017 - Springer Science+Business Media | Calcified Tissue International
Enrique Fernández‐Cara, Irene Marín-Gayte,
This article deals with the solution of some multi-objective optimal control problems for several PDEs: linear and semilinear elliptic equations and stationary Navier-Stokes systems. More precisely, we look for Pareto equilibria associated to standard cost functionals. First, we study the linear and semilinear cases. We prove the existence of equilibria, we deduce appropriate optimality systems, we present some iterative algorithms and we establish convergence results. Then, we analyze the existence ...
Tópico(s): Optimization and Variational Analysis
2020 - American Institute of Mathematical Sciences | Communications on Pure &Applied Analysis
Cara Dosman, Jessica Brian, Irene Drmic, Ambikaipakan Senthilselvan, Mary Harford, Ryan Smith, Waseem Sharieff, Stanley Zlotkin, Harvey Moldofsky, S. Wendy Roberts,
To determine if there is a relationship between low serum ferritin and sleep disturbance in children with autism spectrum disorder, an 8-week open-label treatment trial with oral iron supplementation was conducted as a pilot study. At baseline and posttreatment visits, parents completed a Sleep Disturbance Scale for Children and a Food Record. Blood samples were obtained. Thirty-three children completed the study. Seventy-seven percent had restless sleep at baseline, which improved significantly ...
Tópico(s): Restless Legs Syndrome Research
2007 - Elsevier BV | Pediatric Neurology
Enrique Fernández‐Cara, Irene Marín-Gayte,
This paper deals with the solution of some multi-objective optimal control problems for several PDEs: linear and semilinear elliptic equations and stationary Navier-Stokes systems. Specifically, we look for Nash equilibria associated with standard cost functionals. For linear and semilinear elliptic equations, we prove the existence of equilibria and we deduce related optimality systems. For stationary Navier-Stokes equations, we prove the existence of Nash quasi-equilibria, i.e. solutions to the ...
Tópico(s): Advanced Mathematical Modeling in Engineering
2021 - EDP Sciences | ESAIM Control Optimisation and Calculus of Variations
Emanuele Pivetta, Anna Ravetti, Giulia Paglietta, Irene Cara, Federico Buggè, Gitana Scozzari, Milena Maule, Fulvio Morello, Stefania Locatelli, Enrico Lupia,
During the COVID-19 pandemic, use of telemedicine with the aim of reducing the rate of viral transmission increased. This proof-of-concept observational study was planned to test the feasibility of a home-based lung ultrasound (LUS) follow-up performed by patients with mild COVID-19 infection on themselves. We enrolled patients presenting to the emergency department with SARS-CoV-2 infection without signs of pneumonia and indication to discharge. Each patient received a brief training on how to perform ...
Tópico(s): COVID-19 and healthcare impacts
2022 - Multidisciplinary Digital Publishing Institute | Biomedicines
Yu-An S. Lien, Caitlin Irene Gattuccio, Cara E. Stepp,
The effect of phonetic context on relative fundamental frequency (RFF) was examined, in order to develop stimuli sets with minimal within-speaker variability that can be implemented in future clinical protocols.Sixteen speakers with healthy voices produced RFF stimuli. Uniform utterances consisted of 3 repetitions of the same voiced sonorant-voiceless consonant-voiced sonorant speech sequence; moderately variable sentences contained speech sequences with a single voiceless phoneme (/f/, /s/, /ʃ/, /p/, / ...
Tópico(s): Phonetics and Phonology Research
2014 - American Speech–Language–Hearing Association | Journal of Speech Language and Hearing Research
César Menor, Jesús Fueyo, Óscar Escribano, Carlos Cara, María Dolores Fernández-Moreno, Irene D. Román, Luis Gonzales Guijarro,
The current article describes a new assay to measure thiopurine methyltransferase (TPMT) activity from red blood cells. This method is based on the measurement of the reaction product 6-methylmercaptopurine (6-MMP) by high-performance liquid chromatography (HPLC). 6-MMP is extracted by ethyl acetate with recoveries of 85%, 80%, 80%, and 92% for 50, 250, 500, and 1,000 ng/100 μL packed red blood cells, respectively. 6-MMP was identified and measured by a Zorbax CN column installed in an HPLC system. ...
Tópico(s): Folate and B Vitamins Research
2001 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
Peter Molony, Réiltín Werner, Cara Martin, Deirdre Callanan, Irene H. Nauta, Daniëlle A.M. Heideman, Patrick Sheahan, Cynthia Heffron, Linda Feeley,
There is no consensus on the optimal approach to human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC). Our objective was to classify OPSCC as HPV positive or negative based on (1) morphology alone, (2) p16 status alone, (3) combined morphology and p16 status with additional HPV testing in discordant cases in keeping with 2012 College of American Pathologists (CAP) guidelines (combined approach), and to evaluate and compare survival outcomes.Retrospective review of 168 patients, ...
Tópico(s): Head and Neck Surgical Oncology
2020 - Elsevier BV | Oral Oncology
Produção Nacional
Revisado por pares
Enrique Fernández‐Cara, J. Límaco, Irene Marín-Gayte,
This paper is devoted to the theoretical and numerical analysis of the null controllability of a quasi-linear parabolic equation. First, we establish a local controllability result. The proof relies on an appropriate inverse function argument. Then, we formulate an iterative algorithm for the computation of the null control and we prove a convergence result. Finally, we illustrate the analysis with some numerical experiments.
Tópico(s): Numerical methods in inverse problems
2021 - Elsevier BV | Journal of the Franklin Institute
César Menor, María Dolores Fernández-Moreno, Jesús Fueyo, Óscar Escribano, Tomás Olleros, Encarna Arriaza, Carlos Cara, Michele Lorusso, Marco Di Paola, Irene D. Román, Luis G. Guijarro,
Azathioprine is an immunosuppressant drug widely used. Our purpose was to 1) determine whether its associated hepatotoxicity could be attributable to the induction of a necrotic or apoptotic effect in hepatocytes, and 2) elucidate the mechanism involved. To evaluate cellular responses to azathioprine, we used primary culture of isolated rat hepatocytes. Cell metabolic activity, reduced glutathione, cell proliferation, and lactate dehydrogenase release were assessed. Mitochondria were isolated from ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2004 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Benedetta Vai, Lorenzo Parenti, Irene Bollettini, Cristina Cara, Chiara Verga, Elisa Melloni, Elena Mazza, Sara Poletti, Cristina Colombo, Francesco Benedetti,
One of the greatest challenges in providing early effective treatment in mood disorders is the early differential diagnosis between major depression (MDD) and bipolar disorder (BD). A remarkable need exists to identify reliable biomarkers for these disorders. We integrate structural neuroimaging techniques (i.e. Tract-based Spatial Statistics, TBSS, and Voxel-based morphometry) in a multiple kernel learning procedure in order to define a predictive function of BD against MDD diagnosis in a sample of ...
Tópico(s): Functional Brain Connectivity Studies
2020 - Elsevier BV | European Neuropsychopharmacology
Cara Lawrence, Irene Hong‐McAtee, Bryan D. Hall, James K. Hartsfield, Andrew I Rutherford, Tracy Bonilla, Carolyn Bay,
Abstract Townes–Brocks syndrome is a recognizable variable pattern of malformation caused by mutations to the SALL1 gene located on chromosome 16q12.1. Only three known cases of Townes–Brocks syndrome with proven SALL1 gene mutation and concurrent endocrine abnormalities have been previously documented to our knowledge [Kohlhase et al., 1999; Botzenhart et al., 2005; Choi et al., 2010]. We report on two unrelated patients with Townes–Brocks syndrome who share an identical SALL1 mutation (c.3414_3415delAT), ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2013 - Wiley | American Journal of Medical Genetics Part A
Emanuele Pivetta, Irene Cara, Giulia Paglietta, Virginia Scategni, Giulia Labarile, Maria Tizzani, Giulio Porrino, Stefania Locatelli, G Calzolari, Fulvio Morello, Milena Maule, Enrico Lupia,
Lung Ultrasound Evaluation (LUS) is usefully applied in the Emergency Department (ED) to patients with suspected or confirmed COVID-19. Diaphragmatic Ultrasound (DUS) may provide additional insight into ventilatory function. This proof-of-concept study aimed to evaluate the feasibility of LUS and DUS in a third level ED during the COVID-19 pandemic.Adult patients presenting with COVID-19 symptoms were eligible. After the physical examination, both LUS and DUS (i.e., diaphragmatic motion and thickness) ...
Tópico(s): Sepsis Diagnosis and Treatment
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Colleen Fogarty Draper, Irene Vassallo, Alessandro Di Cara, Cristiana Milone, Ornella Comminetti, Irina Monnard, Jean‐Philippe Godin, Max Scherer, Mingming Su, Jia Wang, Seu‐Ping Guiraud, Fabienne Praplan, Laurence Guignard, Corinne Ammon Zufferey, Maya Shevlyakova, Nashmil Emami, Sofia Moco, Maurice Beaumont, Jim Kaput, François‐Pierre Martin,
Research is limited on diet challenges to improve health. A short-term, vegan protein diet regimen nutritionally balanced in macronutrient composition compared to an omnivorous diet is hypothesized to improve metabolic measurements of blood sugar regulation, blood lipids, and amino acid metabolism.This randomized, cross-over, controlled vegan versus animal diet challenge is conducted on 21 (11 female,10 male) healthy participants. Fasting plasma is measured during a 3 d diet intervention for clinical ...
Tópico(s): Diet and metabolism studies
2017 - Wiley | Molecular Nutrition & Food Research
Irene Gómez‐Cruz, Cristóbal Cara, Inmaculada Romero, Eulógio Castro, Beatriz Gullón,
Exhausted olive pomace (EOP) is the waste generated from the drying and subsequent extraction of residual oil from the olive pomace. In this work, the effect of different aqueous solvents on the recovery of antioxidant compounds from this lignocellulosic biomass was assessed. Water extraction was selected as the best option for recovering bioactive compounds from EOP, and the influence of the main operational parameters involved in the extraction was evaluated by response surface methodology. Aqueous ...
Tópico(s): Fermentation and Sensory Analysis
2020 - Multidisciplinary Digital Publishing Institute | Antioxidants
Cara Marker, Magdalena Weeks, Irene Kraegel,
With a prevalence rate of between 2 and 6 per 1,000 individuals, Autistic Spectrum Disorders (ASD) are increasingly prominent in today's society. Spreading knowledge of various ASD disorders in medical community, along with ever more accurate diagnostic tools, have lead to an increasing number of diagnoses of ASDs. The increased focus on these disorders has, in turn, spurred a flurry of treatment methods in recent years. This article provides an overview of behavioral method of treatment for ASD. ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2007 - Christian Association for Psychological Studies | The Journal of psychology and Christianity
Tópico(s): Social Sciences and Policies
2017 - | Miguel Hernández Communication Journal
Irene Kim, Randall E. Wilson, Cara L. Wellman,
Previously, we demonstrated that plasticity of frontal cortex is altered in aging rats: lesions of the nucleus basalis magnocellularis (NBM) produce larger declines in dendritic morphology in frontal cortex of aged rats compared to young adults. Cholinergic afferents from the NBM modulate glutamatergic transmission in neocortex, and glutamate is known to be involved in dendritic plasticity. To begin to identify possible mechanisms underlying age-related differences in plasticity after NBM lesion, ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2004 - Elsevier BV | Neurobiology of Aging
Cara Gargano sees the plays of Maria Irene Fornes as reflecting ‘nucleate disorder in a system far from equilibrium’ – a theatrical response to the ...
Tópico(s): Theatre and Performance Studies
1997 - Cambridge University Press | New Theatre Quarterly
Andrea Pica, Irene Russo Krauss, Immacolata Castellano, Francesco La Cara, Giuseppe Graziano, Filomena Sica, Antonello Merlino,
The transpeptidation activity of γ-glutamyltranspeptidase from Geobacillus thermodenitrificans (GthGT) is negligible and the enzyme is highly thermostable. Here we have examined the effect of concentrated NaCl solutions on structure, stability, dynamics and enzymatic activity of GthGT. The protein exhibited hydrolytic activity over a broad range of NaCl concentrations. Even at 4.0M NaCl, GthGT retained more than 90% of the initial activity and showed unaltered fluorescence emission, secondary structure ...
Tópico(s): Biochemical and Molecular Research
2012 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Virginia Kaklamani, Jacqueline S. Jeruss, Elisha Hughes, Kalliopi P. Siziopikou, Kirsten M. Timms, Alexander Gutin, Victor Abkevich, Zaina Sangale, Cara Solimeno, Krystal Brown, Joshua T. Jones, Anne-Renee Hartman, Caitlin Meservey, Borko Jovanovic, Irene Helenowski, Seema A. Khan, Kevin P. Bethke, Nora Hansen, Regina Uthe, Sara Giordano, Steven T. Rosen, Kent Hoskins, Jamie Von Roenn, Sarika Jain, Vamsi Parini, William J. Gradishar,
Tópico(s): HER2/EGFR in Cancer Research
2015 - Springer Science+Business Media | Breast Cancer Research and Treatment
Reseña de: Manuel CAMPO VIDAL. La cara oculta de los debates electorales (2017). Arpa y Alfil Editores, S.L. Barcelona, 237 pp. ISBN: 978-84-16601-34-9
Tópico(s): Political Dynamics in Latin America
2017 - | Miguel Hernández Communication Journal
Enrique Fernández‐Cara, Irene Marín-Gayte,
We prove that the limits of the semi-discrete and the discrete semi-implicit Euler schemes for the 3D Navier-Stokes equations supplemented with Dirichlet boundary conditions are suitable in the sense of Scheffer [1]. This provides a new proof of the existence of suitable weak solutions, first established by Caffarelli, Kohn and Nirenberg [2]. Our results are similar to the main result in [3]. We also present some additional remarks and open questions on suitable solutions.
Tópico(s): Nonlinear Partial Differential Equations
2018 - Scientific Research Publishing | Applied Mathematics
Andrea Pica, Irene Russo Krauss, Immacolata Castellano, Mosè Rossi, Francesco La Cara, Giuseppe Graziano, Filomena Sica, Antonello Merlino,
γ-glutamyltranspeptidases (γ-GTs) are ubiquitous enzymes that catalyze the hydrolysis of γ-glutamyl bonds in glutathione and glutamine and the transfer of the released γ-glutamyl group to amino acids or short peptides. These enzymes are generally synthesized as precursor proteins, which undergo an intra-molecular autocatalytic cleavage yielding a large and a small subunit. In this study, circular dichroism and intrinsic fluorescence measurements have been used to investigate the structural features ...
Tópico(s): Amino Acid Enzymes and Metabolism
2012 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics