Ginés Escolar, Irene López-Vílchez, Maribel Díaz‐Ricart, James G. White, Ana M. Galán,
Tissue factor (TF) has been found associated with platelets. Mechanisms responsible for TF-platelet interactions and transport are not fully understood. We explored the response of isolated washed platelets to preparations of recombinant (rTF) or placental (pTF) human TF, exposed on lipid microvesicles (MVs). Sequential ultrastructural and immunocytochemical studies revealed trafficking of these TF preparations, being endocytosed by platelets into channels of the open canalicular system (OCS) and accumulating ...
Tópico(s): Blood properties and coagulation
2008 - Elsevier BV | Thrombosis Research
José J. Zamorano‐León, Inés Hernández-Fisac, Sandra Guerrero, Jorge Tamarit‐Rodriguez, Juana María Santos-Sancho, B. Sopeña, Ginés Escolar, Irene López-Vílchez, Juan Duarte, Alberto Barrientos, Antonio López‐Farré,
Tópico(s): Advanced Drug Delivery Systems
2016 - Elsevier BV | Transplant Immunology
Ginés Escolar, Eduardo Arellano‐Rodrigo, Irene López-Vílchez, Patricia Molina, Juan Sanchis, Joan Carles Reverter, Xavier Carné, Joan Cid, Jaume Villalta, Dolors Tàssies, Ana M. Galán, Maribel Díaz‐Ricart,
Background:Despite the good safety of rivaroxaban, there is limited information on strategies for urgent reversal of its antihemostatic effects.Methods and Results:Alterations of hemostasis induced by rivaroxaban (230 ng/ml) were assessed by using several tests applied to steady and circulating human blood. Effects on thrombin generation (TG) and thromboelastometry (TEM) parameters were measured. Modifications in platelet adhesive, aggregating and procoagulant activities were evaluated in studies with ...
Tópico(s): Hemophilia Treatment and Research
2014 - Japanese Circulation Society | Circulation Journal
Joan Cid, Ginés Escolar, Ana M. Galán, Irene López-Vílchez, Patricia Molina, Maribel Díaz‐Ricart, Miquel Lozano, Larry J. Dumont,
BACKGROUND Cryopreserved platelet (CPP) concentrates exhibit a variety of morphologic and functional alterations that may affect the action of CPP with accelerated platelet (PLT) response and clotting. The objective of this study was to compare the in vitro hemostatic effect of CPP with fresh whole blood (WB) and standard 5‐day PLT concentrates (PCs). STUDY DESIGN AND METHODS WB collected from eight healthy donors was used to prepare fresh WB, PLT‐depleted WB (TPN), and PLT‐restored TPN using CPP (TPN‐ ...
Tópico(s): Periodontal Regeneration and Treatments
2015 - Wiley | Transfusion
Irene Camps-Ortueta, Luis Deltell Escolar, María Francisca Blasco López,
Museums have gone through a modernization process which has seen the adoption of new technologies in what they offer visitors. Within the framework of the new critical museology, these organizations have been transformed into places of encounter and experience, the key tools in this change being socialization and play. Gamification are now intrinsic to collections and are a way of inviting visitors to share new museum experiences through the latest technology such as AR (Augmented Reality) and VR ( ...
Tópico(s): Museums and Cultural Heritage
2021 - University of Navarre | Communication & Society
Rosario Del Rey, Rosario Ortega Ruiz, Irene Feria,
The concept of coexistence has a clear positive meaning and is associated to the main principles of education. However, its analysis is often carried out on the basis of the problems
Tópico(s): Inclusive Education and Diversity
2009 - University of Murcia | Revista Interuniversitaria de Formación del Profesorado Continuación de la antigua Revista de Escuelas Normales
María Consuelo Sáiz Manzanares, Raúl Marticorena Sánchez, María del Camino Escolar Llamazares, Irene González-Díez, Luis Jorge Martín Antón,
Monitoring the learning process during task solving through different channels will facilitate a better understanding of the learning process. This understanding, in turn, will provide teachers with information that will help them to offer individualised education. In the present study, monitoring was carried out during the execution of a task applied in a self-regulated virtual environment. The data were also analysed using data fusion techniques. The objectives were as follows: (1) to examine whether ...
Tópico(s): Innovative Teaching and Learning Methods
2024 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Víctor Manuel Arnau, Irene Checa, María Rocío Bohórquez Gómez-Millán,
El objetivo de este trabajo fue explorar la influencia que el género, la edad, los años nadando y la resiliencia tienen sobre la ansiedad competitiva en una muestra de nadadores escolares (N=74). La resiliencia fue medida con una adaptación española del CD-RISC, mientras que para medir la ansiedad competitiva se utilizó la versión española del CSAI-2R. También se exploraron los datos sociodemográficos (edad, sexo, años nadando y nivel competitivo). Para el análisis de datos se realizaron pruebas no ...
Tópico(s): Sports Performance and Training
2018 - | Informació psicològica/Informació psicològica
Ginés Escolar, Victor Fernandez‐Gallego, Eduardo Arellano‐Rodrigo, Jaume Roquer, Joan Carles Reverter, Victoria Veronica Sanz, Patricia Molina, Irene López-Vílchez, Maribel Díaz‐Ricart, Ana M. Galán,
Apixaban is a new oral anticoagulant with a specific inhibitory action on FXa. No information is available on the reversal of the antihemostatic action of apixaban in experimental or clinical settings. We have evaluated the effectiveness of different factor concentrates at reversing modifications of hemostatic mechanisms induced by moderately elevated concentrations of apixaban (200 ng/ml) added in vitro to blood from healthy donors (n = 10). Effects on thrombin generation (TG) and thromboelastometry ( ...
Tópico(s): Hemophilia Treatment and Research
2013 - Public Library of Science | PLoS ONE
Gerard ILL‐Raga, Ernest Palomer, Eva Ramos‐Fernández, Francesc X. Guix, Mònica Bosch-Morató, Biuse Guivernau, Marta Tajes, Victòria Valls-Comamala, Jordi Jiménez-Conde, Ángel Ois, Fernando J. Pérez-Asensio, Mario Reyes-Navarro, Carolina Caballo, Gabriel Gil‐Gómez, Irene López-Vílchez, Ana M. Galán, Francesc Alameda, Ginés Escolar, Carlos Opazo, Anna M. Planas, Jaume Roquer, Miguel A. Valverde, Francisco J. Muñoz,
Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its correct management. Ischemia produces increased nitric oxide synthesis to recover blood flow but also induces a free radical burst. Nitric oxide and superoxide anion react to generate peroxynitrite that nitrates tyrosines. We found that fibrinogen nitrotyrosination was detected in plasma after the initiation of ischemic stroke in human patients. ...
Tópico(s): Acute Ischemic Stroke Management
2014 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Carmen Márquez Vázquez, Marta Sandoval Mena, Sergio Sánchez, Cecilia Simón Rueda, Anabel Moriña, Beatriz Morgado, Irene Moreno-Medina, José García, Vicente Díaz Gandasegui, Begoña Elizalde-San Miguel,
Las universidades son espacios a los que determinados estudiantes no acceden o en los que encuentran destacados obstáculos para permanecer. Avanzar hacia la construcción de universidades donde todos puedan aprender y participar es una tarea inaplazable que muchas instituciones desconocen cómo enfrentar. Este trabajo tiene como objetivo diseñar un sistema de indicadores que facilite a las instituciones universitarias la autoevaluación de las condiciones que ofrecen a sus estudiantes con respecto ...
Tópico(s): Inclusive Education and Diversity
2021 - Red Iberoamericana de Investigación sobre Cambio y Eficacia Escolar (RINACE) | REICE Revista Iberoamericana sobre Calidad Eficacia y Cambio en Educación
Carlos Ossa Cornejo, Fancy Inés Castro Rubilar, María Teresa Castañeda Díaz, Juana Irene Castro Rubilar,
El siguiente ensayo analiza la metacognición en relación con las nuevas perspectivas constructivistas y como forma de aprendizaje asociado a la gestión del conocimiento y el aprendizaje organizativo. Desde esta nueva perspectiva, se valora el conocimiento de los sujetos no solo como una característica intraindividual, sino más bien interindividual (o grupal) y organizacional. Se presenta el concepto de metacognición institucional como proceso que permite generar un aprendizaje consciente, dialógico ...
Tópico(s): Educational Innovations and Technology
2015 - | Gestión de la educación
Irene Susana Analuisa-Jácome, Juan Carlos Pila Martínez,
Este ensayo, está centrado en analizar ¿Qué competencias debe tener el directivo para la gestión y mejora de un centro educativo?, para lo cual se ha precisado obtener información teórica relevante de los diversos autores en materia educativa como Fullan (2002), Bolívar (2018), Murillo-Torrecilla (2013), Díaz-Barriga (2006), entre otros investigadores quienes han aportado significativamente en el aprendizaje, reaprendizaje del fenómeno educativo. Un buen directivo escolar debe estar centrado siempre ...
Tópico(s): Educational Methods and Psychological Studies
2020 - | Revista Docentes 2 0
Irene López-Vílchez, Maribel Díaz‐Ricart, James G. White, Ginés Escolar, Ana M. Galán,
Circulating tissue factor (TF) has been linked to thrombus propagation. Our group demonstrated that platelets possess mechanisms to capture TF-rich microvesicles (TF-MVs). Serotonin facilitates the development of platelets with increased procoagulant activity. An enhanced platelet serotonin uptake has been identified with increased cardiovascular risk. We have investigated the involvement of serotonergic mechanisms facilitating the interaction of human platelets with TF-MVs. Inhibitory strategies ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2009 - Oxford University Press | Cardiovascular Research
Montserrat Serra, Irene López-Vílchez, Víctor M. Navarro, Ana M. Galán, Ginés Escolar, Rafael Penadés, Rosa Catalán, Lourdes Fañanás, Bárbara Arias, Cristòbal Gastó,
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2011 - Springer Science+Business Media | Psychopharmacology
Para nosotros los psicólogos escolares que trabajamos -los que trabajamos- a salto de mata en un colegio de monjas, una guardería y un colegio público de polígono -póngase por caso- el apellido de (psicólogo) educativo nos viene grande. También le viene grande a los que, a golpe de camino, configuran el equipo municipal com- partido de tres o cuatro pueblos distantes entre sí cuarenta o cincuenta kilómetros. Y es que pertenecemos a otra clase de psicólogos, tal vez la clase B, los vulgares, los poco ...
Tópico(s): Developmental and Educational Neuropsychology
1985 - | APUNTES DE PSICOLOGÍA
Produção Nacional
Revisado por pares
Patrícia Batista Marques, Marisa Irene Siqueira Castanho,
Esta pesquisa insere-se na área da Psicologia Escolar e Educacional e investiga o sentido atribuído à escola por alunos. Trata-se de uma pesquisa participante, com observações de campo, entrevistas e produções diversificadas, com sujeitos de 10 a 13 anos, do Ensino Fundamental II de escolas públicas, realizada no espaço de um projeto de educação não formal, em comunidade da periferia de São Paulo. Pela análise qualitativa, construíram-se núcleos de significação referentes a: visão geral da escola; ...
Tópico(s): Education and Digital Technologies
2011 - Associação Brasileira de Psicologia Escolar e Educacional | Psicologia Escolar e Educacional
... revista. En el campo del deporte en edad escolar, Cristina Menescardi, Irene Moya, Concepcion Ros e Isaac Estevan analizan en su artículo el tiempo de lucha y no lucha en taekwondistas cadetes. El fútbol sala femenino es abordado por Norberto Pascual, Víctor Llorca, José Antonio Carbonell y José Antonio Perez quienes estudian la carga interna en los entrenamientos de fútbol sala femenino de 1ª división nacional. En el camino entre el deporte en edad escolar y la Educación Física, José Eugenio Rodríguez, José ...
Tópico(s): Genetics and Physical Performance
2016 - University of A Coruña | Sportis Scientific Journal of School Sport Physical Education and Psychomotricity
Rodrigo Morchón, Iván Rodríguez-Escolar, Ricardo Enrique Hernández‐Lambraño, José Ángel Sánchez Agudo, José Alberto Montoya-Alonso, Irene Serafín-Pérez, Carolina Fernández-Serafín, Elena Carretón,
Heartworm disease is a vector-borne zoonotic disease caused by Dirofilaria immitis. The Canary Islands (Spain), geolocated close to the coast of Western Sahara, is an archipelago considered hyperendemic where the average prevalence in domestic dogs is high, heterogeneous, and non-uniform. In addition, Culex theileri has been reported as a vector of the disease on two of the most populated islands. Our aim was to develop a more accurate transmission risk model for dirofilariosis for the Canary Islands. ...
Tópico(s): Parasites and Host Interactions
2023 - Multidisciplinary Digital Publishing Institute | Animals
Irene López-Vílchez, Ulla Hedner, Carmen Altisent, Maribel Díaz‐Ricart, Ginés Escolar, Ana M. Galán,
Clinical evidence accumulated from hemophilic patients during prophylaxis with recombinant activated factor VII (rFVIIa) suggests that the duration of the hemostatic action of rFVIIa exceeds its predicted plasma half-life. Mechanisms involved in this outcome have not been elucidated. We have investigated in vitro the redistribution of rFVIIa in platelets from healthy donors, patients with FVII deficiency, and one patient with Bernard-Soulier syndrome. Platelet-rich plasma was exposed to rFVIIa (3 ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2011 - Elsevier BV | American Journal Of Pathology
O presente trabalho tem por objetivo alertar os profissionais de Educação Física sobre a utilização do esporte na escola de maneira irrefletida. Termos como a competição, a cooperação, a lealdade, e o espírito de equipe são alguns dos itens abordados, na tentativa de levantar-se um questionamento maior sobre eles. O esporte pode ser um meio efetivo de Educação, desde que o professor o transforme em tal.
Tópico(s): Physical Education and Pedagogy
2013 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Kinesis
Sı́lvia Pérez-Pujol, Raúl Tonda, Miquel Lozano, Berta Fusté, Irene López-Vílchez, Ana M. Galán, J. Li, Raymond P. Goodrich, Ginés Escolar,
Several strategies are being developed to reduce the risk of pathogen transmission associated with platelet (PLT) transfusion.The impact of a new technology for pathogen reduction based on riboflavin plus illumination (Mirasol PRT, Navigant Biotechnologies, Inc.) at 6.2 and 12.3 J per mL on functional and biochemical characteristics of PLTs was evaluated. PLT concentrates (PCs) obtained by apheresis were treated with Mirasol PRT and stored at 22 degrees C. Modifications in major PLT glycoproteins (GPIbalpha, ...
Tópico(s): Blood groups and transfusion
2005 - Wiley | Transfusion
Irene Elias Rodrigues, Samara de Farias Fernandes FERREIRA,
A pesquisa, objeto deste trabalho, analisou a forma como se materializa a prática pedagógica do professor de Educação Física em um ambiente escolar inclusivo, buscando com isto favorecer uma reflexão mais aprofundada do assunto no meio acadêmico. Foi desenvolvida em uma escola da rede pública do município de Tucuruí-Pa onde a prática inclusiva é vivenciada desde 1994, fato este considerado fundamental para a realização da mesma. O tipo de estudo realizado foi o estudo de caso, sendo que a coleta ...
Tópico(s): Education Pedagogy and Practices
1969 - | REVISTA DA ASSOCIAÇÃO BRASILEIRA DE ATIVIDADE MOTORA ADAPTADA
Annette Kreuz Smolinski, Carmen Casas García, Irene Aguilar Alagarda, Ma Jesús Carbó Gávila,
El trabajo sistemico en la escuela es una herramienta relativamente reciente y altamente eficaz para la solucion de conflictos. El articulo describe la vision sistemica de los problemas mas frecuentes en el aula, resaltando la necesidad de coordinacion y la conveniencia de colaboracion entre los diferentes componentes afectados: familia, profesorado, direccion, personal administrativo, alumnos, etc. Se elaboran los conceptos de rol del psicologo sistemico escolar, demanda, derivacion y se finaliza ...
Tópico(s): Education for Peace and Conflict Resolution
2009 - | Informació psicològica/Informació psicològica
Pau López-Vicente, Irene Cussó-Parcerisas, Eva Rodríguez-Garcia, Jordi Riera-Romaní,
Often educational success is understood as opposed to the concept of school failure. Usually quantifiable indicators are used to measure the phenomena, with little criticism of the reductionism this option poses. In this article we query about how we could assess educational success from a wider perspective in our context. First of all, this study analyses the common principles that appear in the forewords of the different Spanish Education Laws that have been in force during the democratic period ...
Tópico(s): Education and Teacher Training
2016 - Red Iberoamericana de Investigación sobre Cambio y Eficacia Escolar (RINACE) | REICE Revista Iberoamericana sobre Calidad Eficacia y Cambio en Educación
Irene López-Vílchez, Maribel Díaz‐Ricart, Fulgencio Navalón, Esther Gómez‐Gil, Cristòbal Gastó, Ginés Escolar, Ana M. Galán,
Summary Although it is generally acknowledged that serotonin (5-HT) is a weak agonist for human platelets, recent information suggests an association between serotonergic mechanisms and cardiovascular risk. We investigated the action of 5-HT on adhesive, cohesive and procoagulant properties of human platelets. Impact of 5-HT on whole blood coagulation and thrombin generation was measured by modified thromboelastometry (TEM) and specific fluorogenic assays. We evaluated the effects of 5-HT on thrombus ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2009 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Irene López-Vílchez, Maribel Díaz‐Ricart, Berta Fuste, Ana M. Galán, James G. White, Ginés Escolar,
Summary We investigated the interactions of vesicles containing human tissue factor (TF) with platelets and evaluated responses induced by rFVIIa using standard aggregometry, ultrastructural and flow-cytometry techniques. Washed platelets were exposed to a preparation of placental human TF (pTF) or to a relipidated formulation of recombinant humanTF (rTF). Under stirring conditions, pTF induced reversible aggregation with platelets returning to their resting state after 5 minutes. This reversible response ...
Tópico(s): Blood properties and coagulation
2007 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Didac Jerez-Dolz, Sergi Torramadé‐Moix, Marta Palomo, Ana Belén Moreno‐Castaño, Irene López-Vílchez, Rosa Hernandez, Juan J. Badimón, M. Urooj Zafar, Maribel Díaz‐Ricart, Ginés Escolar,
Background and aims Circulating platelet microparticles (PMP) are the most abundant in bloodstream, are highly procoagulant and contribute to cross-talk with inflammatory cells. The aim of the present study was to investigate the interactions of PMP with platelets and explore the involvement of toll-like receptor 4 (TLR-4). Methods PMP were separated by ultracentrifugation of expired platelet concentrates and added to: i) washed platelets, to confirm uptake, by flow cytometry and confocal and transmission ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2019 - Elsevier BV | Atherosclerosis
Produção Nacional
Cláudia Davis, Maria Irene Miranda,
... Fernando. A Origem do Conhecimento e a Aprendizagem Escolar. Porto Alegre: Artmed, 2003.LIMA, Lauro Oliveira de. Piaget - Sugestões aos Educadores. 2. ed. Petrópolis: Vozes, 2000.MIRANDA, Maria Irene. Crianças com Problemas de Aprendizagem na Alfabetização - Contribuições ...
Tópico(s): Linguistics and Language Studies
2012 - | EDUCAÇÃO E FILOSOFIA
Jordi Longás Mayayo, Irene Cussó-Parcerisas, Roser de Querol Duran, Jordi Riera Romaní,
RESUMEN. El artículo presenta un estudio de casos múltiples que identiica factores de apoyo a trayectorias de éxito escolar en estudiantes de secundaria que están en situación de precariedad económica y vulnerabilidad social en cinco ciudades españolas. La investigación aborda la comprensión del éxito escolar evitando la estigmatización que genera la correlación ya demostrada entre fracaso escolar y bajos niveles socio-económico-culturales. La muestra se compone de 30 casos de alumnos que han inalizado ...
Tópico(s): Education in Rural Contexts
2016 - Catholic University of the Most Holy Conception | Revista de Estudios y Experiencias en Educación