Filipa Gil Marques, Esmeralda Poli, João Malaquias, Tânia Carvalho, Ana Portêlo, Afonso Ramires, Fernando Aldeia, Ruy M. Ribeiro, Emília Vitorino, Isabel Diegues, Luís Lopes-da-Costa, Joào Coutinho, Filomena Pina, Marc Mareel, Susana Constantino Rosa Santos,
During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation. Herein, the biological and molecular effects of doses lower than 0.8 Gy per fraction (LDIR), previously described as angiogenesis inducers, were assessed in human peritumoral tissues.Paired biopsies of preperitoneal adipose tissue were surgically collected from 16 patients diagnosed with locally advanced rectal cancer who underwent neo-adjuvant radiotherapy. One of the biopsies is located ...
Tópico(s): Advanced Radiotherapy Techniques
2020 - Elsevier BV | Radiotherapy and Oncology
Filipa Gil Marques, Esmeralda Poli, João Malaquias, Tânia Carvalho, Ana Portêlo, Afonso Ramires, Fernando Aldeia, Ruy M. Ribeiro, Emília Vitorino, Isabel Diegues, Luís Costa, Joào Coutinho, Filomena Pina, Marc Mareel, Susana Constantino Rosa Santos,
During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation. Herein, the biological and molecular effects of doses lower than 0.8 Gy per fraction (LDIR), previously described as angiogenesis inducers, were assessed in human peritumoral tissues.Paired biopsies of preperitoneal adipose tissue were surgically collected from 16 patients diagnosed with locally advanced rectal cancer who underwent neo-adjuvant radiotherapy. One of the biopsies is located ...
Tópico(s): Effects of Radiation Exposure
2019 - Elsevier BV | Radiotherapy and Oncology
Filipa Gil Marques, Lara Carvalho, Joana S. Sousa, José Rino, Isabel Diegues, Esmeralda Poli, Filomena Pina, Leonor Saúde, Susana Constantino Rosa Santos,
Low doses of ionizing radiation (LDIR) activate endothelial cells inducing angiogenesis. In zebrafish, LDIR induce vessel formation in the sub-intestinal vessels during post-embryonic development and enhance the inter-ray vessel density in adult fin regeneration. Since angiogenesis is a crucial process involved in both post-embryonic development and regeneration, herein we aimed to understand whether LDIR accelerate these physiological conditions. Our data show that LDIR upregulate the gene expression ...
Tópico(s): Radiation Therapy and Dosimetry
2020 - Nature Portfolio | Scientific Reports
Filipa Gil Marques, Esmeralda Poli, José Rino, Marta Pinto, Isabel Diegues, Filomena Pina, Susana Constantino Rosa Santos,
At low doses, ionizing radiation activates endothelial cells and promotes angiogenesis. However, it is still unknown if other cells may contribute to this process. In this study, the effect of low-dose ionizing radiation (LDIR) in modulating the pro-angiogenic potential of adipocytes was investigated. Adipocytes are known to secrete multiple angiogenic factors and adipokines that induce angiogenesis. In this work, a confluent monolayer of 3T3-L1 pre-adipocytes was exposed to low doses (0.1 and 0.3 ...
Tópico(s): Biomarkers in Disease Mechanisms
2019 - Radiation Research Society | Radiation Research
Gil Marques Filipa, Poli Esmeralda, Malaquias Joao, Carvalho Tania, P D Mendes Ana, Ramires Afonso, Aldeia Fernando, Ribeiro Ruy Miguel, Emília Vitorino, Diegues Isabel, Costa Luis, Coutinho Joao, Pina Filomena, Mareel Marc, Constantino Rosa Santos Susana,
2019 - Elsevier BV | Radiotherapy and Oncology
Sônia Machado Rocha Ribeiro, Ana Rita Simões, Filipe Rocha, Inês Sofia Vala, Ana Teresa Pinto, Augusto Ministro, Esmeralda Poli, Isabel Maria Diegues, Filomena Pina, Mohamed Amine Benadjaoud, Stéphane Flamant, Radia Tamarat, Hugo Osório, Diogo Pais, Diogo Casal, Fausto J. Pinto, Rune Matthiesen, Manuela Fiúza, Susana Constantino Rosa Santos,
The contribution of radiotherapy, per se, to late cardiotoxicity remains controversial. To clarify its impact on the development of early cardiac dysfunction, we developed an experimental model in which the hearts of rats were exposed, in a fractionated plan, to clinically relevant doses of ionizing radiation for oncological patients that undergo thoracic radiotherapy. Rat hearts were exposed to daily doses of 0.04, 0.3, and 1.2 Gy for 23 days, achieving cumulative doses of 0.92, 6.9, and 27.6 Gy, ...
Tópico(s): Cardiac Imaging and Diagnostics
2022 - Frontiers Media | Frontiers in Oncology
Filipa Gil Marques, Esmeralda Poli, João Malaquias, Tânia Carvalho, Ana Portêlo, Afonso Ramires, Fernando Aldeia, Ruy M. Ribeiro, Emília Vitorino, Isabel Diegues, Luís Costa, Joào Coutinho, Filomena Pina, Marc Mareel, Susana Constantino Rosa Santos,
The publisher regrets that the printed version of the above article contained a number of errors. The correct and final version follows. The publisher would like to apologise for any inconvenience caused. Low doses of ionizing radiation activate endothelial cells and induce angiogenesis in peritumoral tissuesRadiotherapy and OncologyVol. 141PreviewRadiotherapy is widely used to treat malignant tumors. It is mostly delivered in fractionated schemes, consisting of a daily small dose repeated during ...
Tópico(s): Management of metastatic bone disease
2020 - Elsevier BV | Radiotherapy and Oncology
Pedro Miguel Neves, Maria de Fátima de Pina, Isabel Diegues, C. Raimundo, Pedro Marques‐Vidal, Paula Ravasco,
Rationale: Poor nutritional status in cancer is mainly manifested by severe muscle depletion, that may happen at any treatment' stage(curative,adjuvant,palliative), independently of weight. Sarcopenia/myopenia detrimentally impact clinical outcomes; studies suggest a role of phase angle for undernutrition diagnosis.
Tópico(s): Therapeutic Uses of Natural Elements
2020 - Elsevier BV | Clinical Nutrition ESPEN
Margarida Eiras, Isabel Diegues, I. Monteiro Grillo, Ana Escoval,
Purpose: The aim of this paper is a/ to identify and compare existing external review systems for radiation oncology facilities and b/ to distinguish main differences between clinical audit and other external evaluation models and c/ to identify where those models are currently used in European Union member states.Materials: Based on the literature review and the survey conducted between January and April 2007 among representatives of 67 national societies (for diagnostic radiology, radiotherapy ...
Tópico(s): Radiology practices and education
2009 - Elsevier BV | Radiotherapy and Oncology
Produção Nacional
Revisado por pares
Rômulo Romeu Nóbrega Alves, Alberto Kioharu Nishida, Malva Isabel Medina Hernández,
... on traditional knowledge [14-18]. In Brazil alone, Diegues [19] listed 868 relevant publications on traditional human ...
Tópico(s): Aquaculture Nutrition and Growth
2005 - BioMed Central | Journal of Ethnobiology and Ethnomedicine
Francisco George, Tara Shivaji, Cátia Sousa Pinto, Luis Antonio Oliveira Serra, João Valente, Maria João Albuquerque, Paula Cristina Olivença Vicêncio, Ana San-Bento, Paulo Diegues, Paulo Nogueira, Teresa Marques, Helena Rebelo, Filipa Alves da Costa, Raquel Rodrigues, Alexandra Nunes, Vítor Borges, João Paulo Gomes, Daniel A. Sampaio, Paula Barreiro, Sílvia Duarte, Dina Carpinteiro, Joana Mendonça, Catarina Silva, Luı́s Vieira, Maria João Simões, Paulo Gonçalves, Baltazar Nunes, Carlos Alberto Dias, Jorge Machado, Fernando Antônio de Almeida, Elsa A Goncalves, M. Lucília Carvalho, Pedro Viterbo, Dília Jardim, Nuno Lacasta, Filomena Boavida, Ana Pérez, Isabel Santana, Paula Matias, Nuno Banza, C Rabaçal,
We describe the investigation and control of an outbreak of Legionnaires' disease in Portugal in October, November and December 2014. Confirmed cases were individuals with pneumonia, laboratory evidence of Legionella pneumophila serogroup 1 and exposure, by residence, occupational or leisure to the affected municipalities. 49 possible sources were reduced to four potential sources, all industries with wet cooling system, following risk assessment. We geo-referenced cases' residences and the location ...
Tópico(s): Dental Research and COVID-19
2016 - Elsevier BV | Revista Portuguesa de Saúde Pública
Produção Nacional
Revisado por pares
Dalila Rayane Rayane de Lima Pádua, Eduardo Ramirez Asquieri, Yris Maria Fonseca-Bazzo, Diegue Henrique Nascimento Martins, Keyla Oliveira Ribeiro, Clarissa Damiani, Flávio Alves da Silva,
The objective of the present study was to evaluate the behavior of the bioactive compounds during the physiological development of the early Isabel grape cultivar (Vitis labrusca L), cultivated in the Brazilian savanna, with a view to future applications. This is a quantitative study carried out in the field and in the laboratory.The physical and chemical characterization was performed total phenolic compounds, antioxidant activity and the profile of the phenolic compounds by HPLC. The physical and ...
Tópico(s): Horticultural and Viticultural Research
2020 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
Geslaine Rafaela Lemos Gonçalves, Isabel Soares, Valter M. Azevedo‐Santos, Milena Regina Wolf, Atonio Castilho,
... biodiversity that it is a global biosphere reserve (Diegues, 1987; UNESCO, 1999; UNESCO, 2005). We collected specimens ... in coastal waters. Science, 178(4062): 749-750. Diegues, A. C. (1987). Conservação e desenvolvimento sustentado de ... The Authors in Frontiers Geslaine Rafaela L Gonçalves Isabel M Soares Valter M Azevedo-Santos Milena R ... Atonio L Castilho Google Geslaine Rafaela L Gonçalves Isabel M Soares Valter M Azevedo-Santos Milena R ... L Castilho Google Scholar Geslaine Rafaela L Gonçalves Isabel M Soares Valter M Azevedo-Santos Milena R ...
Tópico(s): Microplastics and Plastic Pollution
2019 - Frontiers Media | Frontiers in Marine Science
Produção Nacional
Revisado por pares
... Triple frontera dreams (2012) do escritor brasileiro Douglas Diegues, Xirú (2010) do paraguaio Damián Cabrera e Viralata ( ... como gozo do presente pelo delírio em Douglas Diegues. Uma comunidade de existência que se manifesta na ...
Tópico(s): Latin American Literature Studies
2021 - UNIVERSIDADE DE BRASÍLIA | Estudos de Literatura Brasileira Contemporânea
Yi Qin Gao, Jiyao Li, Bo Dong, Min Zhang, Churen Zhang, Qi Liu, Jingwen Yang, Jianxia Hou, Junying Li, Celia Sommer, Hom‐Lay Wang, Luca Lepidi, Tim Joda, Gustavo Mendonça, Marta Revilla‐León, Joshua Fountain, Wenceslao Piedra‐Cascón, Amirali Zandinejad, Ju-Hyoung Lee, Lauren L. Lustig, Weslie Williams, David Gozalo-Diaz, Sherif Hosney, Maria Gabriela Carranza, Alessandro Geminiani, Carlo Ercoli, Panos Papaspyridakos, Konstantinos Chochlidakis, Kyung Oh, Jeongho Jeon, Jeehwan Kim, Lambert Stumpel, Lucio Lo Russo, Angelo Salamini, Giuseppe Eng, Laura Guida, Mahtab Tabesh, Farahnaz Nejatidanesh, Ghazal Savabi, Amin Davoudi, Omid Savabi, Hesam Mirmohammadi, Marietta Taylor, Mohd Masood, George Mnatzaganian, Cleusa Vieira, Luciano Bachmann, Carol De Andrade, Lima Chaves, Yara Teresinha, Corrêa Silva-Sousa, S. Correa, Da Silva, Edson Alfredo, Diegues Ney, Plinio Pacheco, Rafael Soares Gomes, Altair Antoninha, Del Cury, May Alaidrous, Matthew Finkelman, Yukio Kudara, Hugo Campos, Yongjeong Kim, André De Souza, Nadin Al-Haj, Laura Husain, Mutlu Özcan, Med Dent, Maria‐João Paulo, Mendes Tribst, Amanda Maria De Oliveira, Amanda Maria de Oliveira Dal Piva, A. Werner, Larissa Tavares, Sampaio Silva, Lilian Costa Anami, Marco C. Bottino, Johannes Kleverlaan, Carolina Guedes Barquete, Renata Antoun Simão, Stéphanie Souza, Amanda Lana Fonseca, Barboza Elias, José Marcelo da Silva Guilherme, Antunes Guimarães, Zacarias Herrera, Alexandre Mello, Eduardo Moreira da Silva, Ömür Dede, Ahmet Serkan Küçükekenci, Gdem Kahveci, Aaron Barto, Kraig S Vandewalle, Wen Lien, Kyumin Whang, Susana Bandarra, Joana Neves, Ana Paraíso, Paulo Mascarenhas, Ana Carolina Prado Ribeiro, Isabel Barahona,
Physicomechanical, optical, and antifungal properties of polymethyl methacrylate modified with metal methacrylate monomers
2021 - Elsevier BV | Journal of Prosthetic Dentistry