Kathryn A. Bayles, Daniel R. Boone,
... intelligenceSandra Freitas, Gerardo Prieto, Mário R. Simões, Joana Nogueira, Isabel Santana, Cristina Martins and Lara Alves Alzheimer Disease & ...
Tópico(s): Noise Effects and Management
1982 - American Speech–Language–Hearing Association | Journal of Speech and Hearing Disorders
Daniele de Sanctis, José M. Inácio, Peter F. Lindley, Isabel Sá‐Nogueira, Isabel Bento,
Endo ‐1,5‐α‐ l ‐arabinanases are glycosyl hydrolases that are able to cleave the glycosidic bonds of α‐1,5‐ l‐ arabinan, releasing arabino‐oligosaccharides and l ‐arabinose. Two extracellular endo ‐1,5‐α‐ l ‐arabinanases have been isolated from Bacillus subtilis , BsArb43A and BsArb43B (formally named AbnA and Abn2, respectively). BsArb43B shows low sequence identity with previously characterized 1,5‐α ‐l‐ arabinanases and is a much larger enzyme. Here we describe the 3D structure of native BsArb43B, biochemical ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2010 - Wiley | FEBS Journal
G. Gim�nez-Jurado, María José Valderrama, Isabel Sá‐Nogueira, Isabel Spencer‐Martins,
Tópico(s): Plant Pathogens and Resistance
1995 - Springer Science+Business Media | Antonie van Leeuwenhoek
Sílvia Rodrigues Gavinho, Ana Sofia Pádua, Isabel Sá‐Nogueira, Jorge Silva, João Paulo Borges, L.C. Costa, M.P.F. Graça,
Polymeric membranes are widely used in guided bone regeneration (GBR), particularly in dentistry. In addition, bioactive glasses can be added to the polymers in order to develop a matrix that is osteoconductive and osteoinductive, increasing cell adhesion and proliferation. The bioactive glasses allow the insertion into its network of therapeutic ions in order to add specific biological properties. The addition of zinc into bioactive glasses can promote antibacterial activity and induce the differentiation ...
Tópico(s): Facial Trauma and Fracture Management
2023 - Multidisciplinary Digital Publishing Institute | Materials
E. Nogueira, Isabel Bravo, P. Montero, Pilar Díaz‐Tapia, S. Calvo, Begoña Ben-Gigirey, Rosa Isabel Figueroa, José L. Garrido, Isabel Ramilo, Nuria Lluch, Araceli E. Rossignoli, Pilar Riobó, Francisco Rodríguez,
Alexandrium minutum blooms generally occur in semi-enclosed sites such as estuaries, harbours and lagoons, where enhanced stratification, restricted circulation and accumulation of resting cysts in the sediment set suitable habitat conditions for the proliferation of this paralytic shellfish poisoning toxigenic species. In the Galician Rías Baixas (NW Iberian Peninsula), according to weekly time-series between 1994 and 2020, blooms of A. minutum were recurrent in small, shallow estuarine bays inside ...
Tópico(s): Microbial Community Ecology and Physiology
2022 - Elsevier BV | Ecological Indicators
Rosiane Rocha, José Pinela, Rui M.V. Abreu, Mikel Añibarro-Ortega, Tânia C. S. P. Pires, Ana Saldanha, Maria José Alves, António Nogueira, Isabel C.F.R. Ferreira, Lillian Barros,
Heat (HAE)- and ultrasound (UAE)-assisted extraction methods were implemented to recover anthocyanins from red raspberry. Processing time, ethanol concentration, and temperature or ultrasonic power were the independent variables combined in five-level rotatable central composite designs coupled with response surface methodology (RSM) for processes optimization. The extraction yield and levels of cyanidin-3-O-sophoroside (C3S) and cyanidin-3-O-glucoside (C3G) were monitored by gravimetric and HPLC-DAD- ...
Tópico(s): Microbial Metabolism and Applications
2020 - Multidisciplinary Digital Publishing Institute | Processes
Ana Margarida Castro, Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Ruth Pereira,
The textile industry has an important role in the economic development of several countries; however, it consumes large amounts of water and generates huge quantities of wastewater. These effluents are of great environmental concern due to their complex chemical content, known by their toxicity and low biodegradability, which can cause harmful effects to the aquatic environment. In the present study, bioassays with aquatic species were employed to evaluate the toxicity of effluent samples collected ...
Tópico(s): Microplastics and Plastic Pollution
2019 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Catarina F. Marques, Susana M. Olhero, P.M.C. Torres, J.C.C. Abrantes, Sara Fateixa, Helena I. S. Nogueira, Isabel Ribeiro, Ana Bettencourt, Aureliana Sousa, Pedro L. Granja, J.M.F. Ferreira,
Advances on the fabrication of sintering-free biphasic calcium phosphate (BCP)/natural polymer composite scaffolds using robocasting as additive manufacturing technique are presented in the present work. Inks with high amounts of BCP powders (45 vol%) containing different HA/β-TCP ratios, in presence of crosslinked polymer, were successfully fine-tuned for extrusion by robocasting. The non-existence of sintering step opened the possibility to obtain drug loaded scaffolds by adding levofloxacin to ...
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2018 - Elsevier BV | Materials Science and Engineering C
Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Fernando Gonçalves, Ruth Pereira,
High quantities of industrial wastewaters containing a wide range of organic and inorganic pollutants are being directly discharged into the environment, sometimes without proper treatment. Nanotechnology has a tremendous potential improving the existing treatments or even develop new treatment solutions. In this study, nano-TiO2 or nano-Fe2O3 was used for the photocatalytic treatment of kraft pulp mill effluent and mining effluent. The experiments with the organic effluent lead to reduction percentages ...
Tópico(s): Advanced oxidation water treatment
2017 - Taylor & Francis | Environmental Technology
Produção Nacional
Revisado por pares
Paulo César Koch Nogueira, Isabel de Pádua Paz,
The abnormalities of the genitourinary tract development are the leading cause of chronic kidney disease (CKD) in children. The diagnosis of this disease in Brazil is late and incomplete, which results in increased morbidity and mortality in this age group. Early diagnosis of this condition is the prerogative of generalist pediatricians, and the aim of this study was to review the clinical signs and symptoms associated with developmental abnormalities of the genitourinary tract. Based on the description ...
Tópico(s): Renal and related cancers
2016 - Elsevier BV | Jornal de Pediatria
Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Fernando Gonçalves, Armando C. Duarte, Ruth Pereira,
Tópico(s): TiO2 Photocatalysis and Solar Cells
2016 - Springer Science+Business Media | Water Air & Soil Pollution
Felicitas Lopez Vicchi, Guillermina M. Luque, Belén Brie, Juan Patricio Nogueira, Isabel García Tornadú, Damasia Becú‐Villalobos,
The importance of dopamine in central nervous system function is well known, but its effects on glucose homeostasis and pancreatic β cell function are beginning to be unraveled. Mutant mice lacking dopamine type 2 receptors (D2R) are glucose intolerant and have abnormal insulin secretion. In humans, administration of neuroleptic drugs, which block dopamine receptors, may cause hyperinsulinemia, increased weight gain and glucose intolerance. Conversely, treatment with the dopamine precursor l-DOPA ...
Tópico(s): Metabolism, Diabetes, and Cancer
2015 - Elsevier BV | Pharmacological Research
Verónica Nogueira, Isabel Lopes, Ana C. Freitas, Teresa Rocha‐Santos, Fernando Gonçalves, Armando C. Duarte, Ruth Pereira,
Olive mill wastewater (OMW) still is a major environmental problem due to its high chemical oxygen demand (COD) and total phenolic content (TPC), contributing for the high toxicity and recalcitrant nature. Several attempts have been made for developing more efficient treatment processes, but no chemical or biological approaches were found to be totally effective, especially in terms of toxicity reduction. In this context, the main purpose of this study was to investigate the treatability of OMW by ...
Tópico(s): TiO2 Photocatalysis and Solar Cells
2015 - Elsevier BV | Ecotoxicology and Environmental Safety
Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Fernando Gonçalves, Ruth Pereira,
Nanomaterials (NMs) are widely recommended for wastewater treatments due to their unique properties. Several studies report the different advantages of nanotechnology in the remediation of wastewaters, but limited research has been directed toward the fate and potential impacts of the solid residues (SRs) produced after the application of such technologies. The present work aimed at investigating the ecotoxicity of SRs resulting from the treatment of three effluents (OOMW, kraft pulp mill, and mining ...
Tópico(s): Nanomaterials for catalytic reactions
2015 - Elsevier BV | Aquatic Toxicology
Produção Nacional
Revisado por pares
Maximiliano Ribeiro Guerra, Gulnar Azevedo e Silva, Mário Círio Nogueira, Isabel Cristina Gonçalves Leite, Raquel de Vasconcellos Carvalhães de Oliveira, Jane Rocha Duarte Cintra, Maria Teresa Bustamante-Teixeira,
Breast cancer is the most frequent neoplasm in women, and some studies have shown social inequalities in incidence and survival, which are poorly investigated in Brazil. To assess iniquity in prognosis, a hospital-based cohort study was carried out. Follow-up was made by active search in medical records and in the Mortality Information System, phone calls, and consultation on Individual Tax-Collection Record status. Survival functions were estimated by the Kaplan-Meier method, and the Cox proportional ...
Tópico(s): Cancer Risks and Factors
2015 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Maria G. Rasteiro, Nélson Abrantes, Fernando Gonçalves, Amadeu M.V.M. Soares, Armando C. Duarte, Ruth Pereira,
Tópico(s): Healthcare and Environmental Waste Management
2015 - Springer Science+Business Media | Environmental Science and Pollution Research
Viviana Loria‐Kohen, Thais Lourenço-Nogueira, Isabel Espinosa‐Salinas, Francisco Marı́n, Cristina Soler‐Rivas, Ana Ramı́rez de Molina,
Over the past two decades, there has been a steady flow of publications about the health effects related to mushrooms consumption. They represent a valuable source of protein, present high levels of fiber, some vitamins and minerals, and they also have reduced amount of fat and sodium. In addition, their complex carbohydrates profile can strengthen considerably the immune system.Edible mushrooms have been related to significant functional properties due to their bioactive compounds, such as eritadenine, ...
Tópico(s): Herbal Medicine Research Studies
2014 - | Journal of Pharmacy and Nutrition Sciences
Verónica Nogueira, Isabel Lopes, Teresa Rocha‐Santos, Ana L. Santos, Maria G. Rasteiro, Filipe E. Antunes, Fernando Gonçalves, Amadeu M.V.M. Soares, Ângela Cunha, Adelaide Almeida, Newton C. M. Gomes, Ruth Pereira,
In this study the effect of organic and inorganic nanomaterials (NMs) on the structural diversity of the soil microbial community was investigated by Denaturing Gradient Gel Electrophoresis, after amplification with universal primers for the bacterial region V6–V8 of 16S rDNA. The polymers of carboxylmethyl-cellulose (CMC), of hydrophobically modified CMC (HM-CMC), and hydrophobically modified polyethylglycol (HM-PEG); the vesicles of sodium dodecyl sulphate/didodecyl dimethylammonium bromide (SDS/DDAB) ...
Tópico(s): Geochemistry and Elemental Analysis
2012 - Elsevier BV | The Science of The Total Environment
Outi Hovatta, Miodrag Stojković, Maria José Nogueira, Isabel Varela‐Nieto,
In 2002, the European Science Foundation (ESF) published a Science Policy Briefing entitled Human Stem Cell Research: Scientific Uncertainties and Ethical Dilemmas. Since then there have been significant advances in the field of research, notably the emergence of regenerative medicine (RM) which promises to be a fascinating development, opening the possibility of repairing or replacing tissue or organ function lost due to age, disease, damage, or congenital defects using human stem cells (hSCs)—an ...
Tópico(s): Ethics and Legal Issues in Pediatric Healthcare
2010 - Oxford University Press | Stem Cells
J A Martínez-Piñeiro, N Flores, Santiago Isorna, E. Solsona, James Sebastian, C Pertusa, L.A. Rioja, L. Martínez-Piñeiro, Rhonda Vela, José Emilio Camacho, José Luís Nogueira, Isabel Pereira, Luis Resel, Pedro Muntañola, F. Galvis, Nicolás Chesa, J. Alonso Torres, Joaquı́n Carballido, C. Bernuy, SALVADOR ARRIBAS, Rosário Madero,
To determine the efficacy of a three-fold reduced dose (RD, 27 mg) of intravesical bacille Calmette-Guérin (BCG) against the standard dose (81 mg) in patients with superficial bladder cancer, assessing recurrence, progression, and differences in toxicity. Five hundred patients with superficial bladder cancer (Ta, T1, Tis) were enrolled and randomly assigned to be treated after transurethral resection of all visible lesions with intravesical BCG Connaught strain (weekly × six and thereafter fortnightly × ...
Tópico(s): Amino Acid Enzymes and Metabolism
2003 - Elsevier BV | Urologic Oncology Seminars and Original Investigations
J.A. Martínez‐Pin ̃eiro, N Flores, Santiago Isorna, E. Solsona, J. L. Sebastian, C Pertusa, L.A. Rioja, L. Martínez‐Pin ̃eiro, R. Vela, José Emilio Camacho, José Luís Nogueira, Isabel Pereira, Luis Resel, Praise Ola, F. Galvis, Nicolás Chesa, Javier Torres, Joaquı́n Carballido, C. Bernuy, SALVADOR ARRIBAS, Rosário Madero,
Objectives To determine the efficacy of a three‐fold reduced dose (RD, 27 mg) of intravesical bacille Calmette‐Gue´rin (BCG) against the standard dose (81 mg) in patients with superficial bladder cancer, assessing recurrence, progression and differences in toxicity. Patients and methods Five hundred patients with superficial bladder cancer (Ta, T1, Tis) were enrolled and randomly assigned to be treated after transurethral resection of all visible lesions with intravesical BCG Connaught strain (weekly× ...
Tópico(s): Infectious Disease Case Reports and Treatments
2002 - Wiley | BJU International
Sandra Nogueira, Isabel Abreu‐Lima, Catarina Canário, Orlanda Cruz,
Background: Parenting is a challenging endeavor, particularly for low-income families, who are often exposed to multiple stressors known to jeopardize children's development.Research indicates that evidence-based parenting interventions mitigate the adverse effects of growing up in low-income families.The purpose of the current study is to evaluate the efficacy of Group Triple P -Positive Parenting Program in a sample of Portuguese low-income families assisted by social welfare services.Methods/Design: ...
Tópico(s): Family and Disability Support Research
2021 - Elsevier BV | Children and Youth Services Review
R. Nogueira, Isabel C.F.R. Ferreira, P. Janknecht, Juan J. Rodrı́guez, Pedro Oliveira, A. G. Brito,
Natural interactions between water, soil, atmosphere, plants and microorganisms include physical, chemical and biological processes with decontaminating capacities. Natural or energy-saving wastewater treatment systems utilize these processes and thereby enable a sustainable management in the field of wastewater treatment, offering low investment and operation costs, little or no energy consumption, little and low-skill labor requirements, good landscape integration and excellent feasibility for ...
Tópico(s): Water Systems and Optimization
2007 - Pergamon Press | Water Science & Technology
Maria Leonor Faleiro, Ana Cristina Marques, João Carlos Martins, Luísa Jordão, Isabel Nogueira, Nadiia I. Gumerova, Annette Rompel, Manuel Aureliano,
The increase in bacterial resistance to antibiotics has led researchers to find new compounds or find combinations between different compounds with potential antibacterial action and with the ability to prevent the development of antibiotic resistance. Polyoxotungstates (POTs) are inorganic clusters that may fulfill that need, either individually or in combination with antibiotics. Herein, we report the ability of the polyoxotungstates (POTs) with Wells-Dawson P2W18, P2W17, P2W15, and Preyssler P5W30 ...
Tópico(s): Bacterial biofilms and quorum sensing
2022 - Multidisciplinary Digital Publishing Institute | Biology
Ander Zugazaga, Malgorzata Agata Stachno, A. López García, German Alirio Tovar, Virginia Benito, Ignasi Guasch, Isabel Nogueira, P. Puyalto, Jaume Sampere,
Tópico(s): Tracheal and airway disorders
2021 - Springer Science+Business Media | European Radiology
Produção Nacional
Revisado por pares
Luíza Aymée, Wilmara Rampinelli Reuter Gregg, Ana Paula Loureiro, Maria Isabel Nogueira Di Azevedo, Juliana Pedrosa, Juliana dos Santos Loria de Melo, Filipe Aníbal Carvalho‐Costa, Guilherme Nunes de Souza, Walter Lilenbaum,
Bovine genital leptospirosis (BGL) is characterized by silent chronic reproductive disorders, most related to early embryonic death leading to estrus repetition, subfertility and abortions. However, most studies were conducted in slaughterhouses, which lacks reproductive and sanitary history of the studied animals. This study aimed to evaluate the occurrence of Leptospira sp. infection in live cows with history of low reproductive efficiency. Blood, urine, cervico-vaginal mucus and uterine fragment ...
Tópico(s): Humic Substances and Bio-Organic Studies
2021 - Elsevier BV | Veterinary Microbiology
Produção Nacional
Revisado por pares
Ricardo Sant’Anna da Costa, Maria Isabel Nogueira Di Azevedo, Ana Luiza dos Santos Baptista Borges, Filipe Aníbal Carvalho‐Costa, Gabriel Martins, Walter Lilenbaum,
(1) Background: Dogs are known as hosts of Leptospira interrogans and can spread this bacterium to the environment. Although Canicola is responsible for determining chronic disease in dogs, when affected by incidental serogroups such as Icterohaemorrhagiae, acute disease may occur with a predominance of clinical signs with hepatic and renal changes. In endemic areas, it is a serious public health problem. Thus, this study aims to estimate the incidence and duration of elimination of leptospires ...
Tópico(s): Veterinary medicine and infectious diseases
2021 - Multidisciplinary Digital Publishing Institute | Animals
Miguel P. Batista, V.S.S. Gonçalves, Frédéric Bustos Gaspar, Isabel Nogueira, Ana A. Matias, Pavel Gurikov,
Aerogels produced from marine polymers, such as chitosan and alginate, are of interest for wound healing applications due to their attractive properties. These properties can be the aerogel's high porosity along with the antimicrobial activity of chitosan or the capacity to provide a moist environment of alginate. The aim of this work was to develop a new route towards hybrid alginate-chitosan aerogel fibres and to evaluate their potential for wound healing applications. The influence of chitosan ...
Tópico(s): Wound Healing and Treatments
2020 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Luciana dos Santos Medeiros, Susan Christina Braga Domingos, Maria Isabel Nogueira Di Azevedo, Rui Carlos Peruquetti, Narianne Ferreira de Albuquerque, Paulo Sérgio D’Andrea, André Luís Botelho, Charle Ferreira Crisóstomo, Anahi S. Vieira, Gabriel Martins, Bernardo Rodrigues Teixeira, Filipe Aníbal Carvalho‐Costa, Walter Lilenbaum,
Leptospira is a bacteria that causes leptospirosis and is transmitted through water, soil, or mud that is contaminated by the urine of infected animals. Although it is mainly associated with the urban environment, Leptospires also circulate in rural and wild environments. This study aimed to investigate the role of small mammals in leptospirosis epidemiology in the western Amazon, Brazil. In total, 103 animals from 23 species belonging to the orders Didelphimorphia and Rodentia were captured. Blood, ...
Tópico(s): Zoonotic diseases and public health
2020 - Frontiers Media | Frontiers in Veterinary Science
Andrew White, Charlotte Sarfas, Laura Sibley, Jennie Gullick, Simon Clark, Emma Rayner, Fergus Gleeson, Martí Català, Isabel Nogueira, Pere‐Joan Cardona, Cristina Vilaplana, Mike Dennis, Ann Williams, Sally Sharpe,
Ten million cases of tuberculosis (TB) were reported in 2018 with a further 1.5 million deaths attributed to the disease. Improved vaccination strategies are urgently required to tackle the ongoing global TB epidemic. In the absence of a validated correlate of protection, highly characterised pre-clinical models are required to assess the protective efficacy of new vaccination strategies. In this study, we demonstrate the application of a rhesus macaque ultra-low dose (ULD) aerosol M. tuberculosis ...
Tópico(s): Influenza Virus Research Studies
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics