Arthur Leathley, Transport Correspondent, Tom Baldwin and David Lister, David Adams, Helen Johnstone, Joanna Hunter, Andrew Pierce, Sally Brock, Lawrence T. Roach, Sarah Potter, Paul Hoggart, Mark Souster, David Rhys Jones, Richard Hobson, Robert Lea, Christopher Walker, Chief Ireland Correspondent, Raymond Snoddy, Media Editor, Gavin Lumsden, Debra Craine and Dalya Alberge, Philip Howard, Boyd Farrow, David Smith, Dina Shiloh, Michael Binyon and Philip Webster, Joanna Bale, James Bone, Lea Paterson, Alasdair Murray and Adam Jones, Clive Davis, Alexandra Frean Social Affairs Correspondent, Richard Caborn, John Battle, Michael Wilks Chairman, Ginny Dougary, Barbara Ellen, Michael Baum (President), David Robinson and Perry Cleveland-Peck, Tony Patrick, Fraser Nelson, Retail Correspondent, Raymond Snoddy, Gerald Davies, Giles Coren, Pat Gibson, Cornelius Lysaght, Jason Allardyce, Stewart Tendler Crime Correspondent, Dominic Walsh, Raymond Keene Chess Correspondent, Michael Harvey, Rosemary Whiting, Robert Atkins, Anita Chaudhuri, Robin Young, Oliver Wright, Stephen Farrell, Mark Inglefield, Eve-Ann Prentice, Ian Hughes, Jason Allardyce Scottish Political Reporter, Mike Bradley, Alix Ramsay, Tennis Correspondent, Jill Sherman, Whitehall Editor, Peter Barnard, David Charter, Paul McCann, Media Correspondent, Derwent May, David L. Gosling, Raymond Durrant, Caroline Merrell Banking Correspondent, Paul Durman, Paul McCann, Ross Clark, David Lister, John Hopkins, Adrian Brodkin, Barry Millington, Rob Wright, Stephen Wood, David Watts, Dalya Alberge, Arts Correspondent, Adam Jones, Raymond Keene, Adam Sage, Matt Dickinson, Winifred Stephenson, Stefano Hatfield, M. J. Greenleaves, Imogen Edwards-Jones, Carl Mortished, International Business Editor, J. T. Fetherston-Dilke, Melissa Kite, Martin Luther King, Cathy Harris, Jill Sherman, Richard Owen, Lysaght's Turf, Damian Whitworth, P. J. Harford, John Stern, Brian Simpson, Nick Hasell, Edwina Charlett-Green, Nick Kelly, Philip Webster, Political Editor, Hettie Judah, Robert Cole Edited, Jennifer O'Neill, Tom Baldwin and Roland Watson, Robert Wyhmant, John Allison, Nick Szczepanik, Chris Davies, Mary Ann Sieghart, Giles Whittell, Philip Webster Political Editor, Christopher Walker, James Pringle, Valerie Elliott, Countryside Editor, Jane Shilling, Brian MacArthur, Alex O'Connell, Matthew Parris, Chris McGrath, George Caulkin, Russell Jenkins, Caitlin Moran, Peter Riddell, Ben MacIntyre, Jeremy Hart, Ian Brodie, Michael Dynes, Philip Webster, David Sinclair, Simon Jenkins, Fraser Nelson, Tim Jones, Martin Waller, Chris Ayres, Christopher Irvine, William de Segundo, Pugh and Way, Benedict Nightingale, David Vance, Stephen Dalton, Helen Rumbelow, Medical Reporter, Joanna Bale and Emily Davies, Adam Sherwin, Michael Evans, Andrew Finkel, Allan Hall, Sally Patten, Roland Watson Chief Political Correspondent, Jan Raath, Fraser Nelson Retail Correspondent, Roland Watson and Tom Baldwin, Lisa Verrico,
... months of disruption' Bidding for contracts RDR and Isabel dos Santos Wilde's lover was seen as 'Victim' Correction ...
2000 - Gale Group | TDA
Isabel dos‐Santos‐Silva, Anthony J. Swerdlow, Charles Stiller, Andrew Reid,
... and Wales: Trends in children compared with adults Isabel dos Santos Silva, Corresponding Author Isabel dos Santos Silva isabel.silva@lshtm.ac.uk Cancer and ... London, UKSearch for more papers by this author Isabel dos Santos Silva, Corresponding Author Isabel dos Santos Silva isabel.silva@lshtm.ac.uk Cancer and Public Health ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
1999 - Wiley | International Journal of Cancer
By Barrie Clement, Philip Webster, From Richard Owen, , By Craig Seton, By Richard Dowden, From Peter DavenDort, By Staff Reporters, By Philip Robinson, By Philip Webster, Political Reporter, From Richard Ford, , By Clifford Webb, Motoring Correspondent, By Lucy Hodges Education Correspondent, By Kenneth Gosling, From Rupert Morris, , By Barrie Clement, Labour Reporter, By Geraldine Norman Sale Room Correspondent, By Our Religious Affairs Correspondent, By our Political Reporter, , By a Staff Reporter, By Pearce Wright, Science Editor, By Colin Hughes, By David Hewson, Arts Correspondent, By Michael Baily, Transport Editor, By Our Commercial Editor, By Richard Evans Lobby Reporter, By Nicholas Timmins, Social Service Correspondent, By Derek Harris, Commercial Editor, By Richard Evans, Lobby Reporter, By Anthony Bevins, Political Correspondent, From Michael Prest, , From Alan McGregor, From Robert Fisk, , From Christopher Walker, , From Richard Owen, From Robert Schuil, From John Best, , From Florencia Varas, , Douglas Tweedale, , From Michael Hamlyn, From Peter Nichols, From Diana Geddes, From Mary Lee, , From David Watts, From Michael Binyon, From Keith Dalton, Caroline Moorehead, Celia Brayfield, Nicholas Kenyon, Irving Wardle, Anthony Masters, David Wade, Simon Barnes, David Butler, Roy Strong, HELEN HOPKIN, , AUDREY CREED, , ELISABETH WOOLLCOMBE, , OZER KORAY, , ALEX BERNSTEIN, , L. A. SIEDENTOP, , LIONEL BLOCH, , EDGAR PALAMOUNTAIN, , J. WIGLEY, , PERCY RICHER, , ANNA MARY YOUNG, , JOHN FOOT, , JOHN HUNT, , PETER MELCHETT, , MOLSON, , TORDOFF, , DONALDSON, , HUGH CARADON, , TAM DALYELL, , GRAHAM LYNCH-WATSON, , MOYNE, , BRIAN PINK, , Teresa McLean, By a Special Correspondent, By Geraldine Norman, Sale Room Correspondent, Brian Alderson, Marcel Berlins, A. S. Byatt, Stuart Evans, Elaine Feinstein, Gay Firth, Gontran Goulden, Tim Heald, John Higgins, Richard Holmes, Glyn Daniel, Philip Howard, Rory Coonan, Tom Hutchinson, Fiona MacCarthy, John Nicholson, Robert Nye, Isabel Raphael, Peter Jones, Nicholas Shakespeare, Andrew Sinclair, Philippa Toomey, Ruth Stungo, Hugo Vickers, Woodrow Wyatt, R.C., Edited by Shona Crawford Poole, Philip Ray, Michael Coleman, Rob Neillands, Stan Hey, Jane MacQuitty, Ashley Stephenson, Beryl Downing, Peter Philp, Jeremy Flint, Judy Froshaug, Harry Golombek, Prudence Hone, Peter Waymark, P.W., Christopher Warman, Executive Editor Kenneth Fleet, Dar es Salaam, By Christopher Dunn, By David Smith Economics Correspondent, By Jeremy Warner, By Alison Eadie, By Derek Pain, Pam Spooner, edited by Lorna Bourke, Conal Gregory, Ian McDonald, Richard Thomson, R.T., By David Hands, Rugby Correspondent, By Clive White, By Paul Harrison, By Nicholas Harling, David Miller, By Sydney Friskin, From Richard Streeton, , By William Stephens, From Ray Kennedy, , By Mandarin, Peter Dear, Peter Davalle, From Richard Ford,
... Advertising: Gus, Bdma, Bank Of Scotland, Jose Eduardo DOS Santos, British Assets Trust, Multiple Display Advertisements, Multiple Sclerosis, ...
1984 - Gale Group | TDA
Yosr Hamdi, Penny Soucy, Véronique Adoue, Kyriaki Michailidou, Sander Canisius, Audrey Lemaçon, Arnaud Droit, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Caroline Baynes, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Barbara Burwinkel, Jenny Chang‐Claude, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Flyger Henrik, Montserrat García‐Closas, Graham G. Giles, Mark S. Goldberg, Anna González‐Neira, Grethe Irene Grenaker-Alnæs, Pascal Guénel, Lothar Haeberle, Christopher A. Haiman, Ute Hamann, Emily Hallberg, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Michael E. Jones, Maria Kabisch, Vesa Kataja, Diether Lambrechts, Loı̈c Le Marchand, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Mel Maranian, Sara Margolin, Frederik Marme, Roger L. Milne, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Curtis Olswold, Julian Peto, Dijana Plaseska‐Karanfilska, Katri Pylkäs, Paolo Radice, Anja Rudolph, Elinor J. Sawyer, Marjanka K. Schmidt, Xiao-Ou Shu, Melissa C. Southey, Anthony J. Swerdlow, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Diana Torres, Thérèse Truong, Celine M. Vachon, Ans M.W. van den Ouweland, Qin Wang, Robert Winqvist, kConFab AOCS Investigators, Wei Zheng, Javier Benı́tez, Georgia Chenevix‐Trench, Alison M. Dunning, Paul D.P. Pharoah, Vessela N. Kristensen, Per Hall, Douglas F. Easton, Tomi Pastinen, Silje Nord, Jacques Simard,
... 5 , Peter Devilee 45,46 , Thilo Dörk 16 , Isabel Dos-Santos-Silva 47 , Mikael Eriksson 22 , Peter A. Fasching ...
Tópico(s): Genomics and Chromatin Dynamics
2016 - Impact Journals LLC | Oncotarget
Amanda Eng, Valerie McCormack, Isabel dos‐Santos‐Silva,
In a systematic review and meta-analysis, Isabel dos Santos Silva and colleagues estimate the prevalence of receptor-defined subtypes of breast cancer in North Africa and sub-Saharan Africa. Please see later ...
Tópico(s): Colorectal Cancer Screening and Detection
2014 - Public Library of Science | PLoS Medicine
Xiang Jiao, Christos Aravidis, Rajeshwari Marikkannu, Johanna Rantala, Simone Picelli, Tatjana Adamović, Tao Liu, Paula Maguire, Bárbara Kremeyer, Liping Luo, Susanna von Holst, Vinaykumar Kontham, Jessada Thutkawkorapin, Sara Margolin, Quan Du, Johanna Lundin, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Christine B. Ambrosone, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Matthias W. Beckmann, Carl Blomqvist, William J. Blot, Bram Boeckx, Stig E. Bojesen, Bernardo Bonanni, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Jenny Chang‐Claude, Fergus J. Couch, Angela Cox, Simon S. Cross, Sandra Deming-Halverson, Peter Devilee, Isabel dos‐Santos‐Silva, Thilo Dörk, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Henrik Flyger, Marike Gabrielson, Montserrat García‐Closas, Graham G. Giles, Anna González‐Neira, Pascal Guénel, Qi Guo, Melanie Gündert, Christopher A. Haiman, Emily Hallberg, Ute Hamann, Patricia Harrington, Maartje J. Hooning, John L. Hopper, Guanmengqian Huang, Anna Jakubowska, Michael E. Jones, Michael J. Kerin, Veli‐Matti Kosma, Vessela N. Kristensen, Diether Lambrechts, Loı̈c Le Marchand, Jan Lubiński, Graham J. Mann, John W.M. Martens, Thomas Ind, Roger L. Milne, Anna Marie Mulligan, Susan L. Neuhausen, Heli Nevanlinna, Julian Peto, Katri Pylkäs, Paolo Radice, Valerie Rhenius, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Jacques Simard, Melissa C. Southey, Anthony J. Swerdlow, Thérèse Truong, Camilla Wendt, Robert Winqvist, Wei Zheng, Javier Benı́tez, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Kamila Czene, Per Hall, Annika Lindblom,
... L. Deming-Halverson 14 , Peter Devilee 51,52 , Isabel dos-Santos-Silva 53 , Thilo Dörk 54 , Mikael Eriksson 22 , ...
Tópico(s): BRCA gene mutations in cancer
2017 - Impact Journals LLC | Oncotarget
Joanna M. N. Guimarães, Goro Yamada, Sharrelle Barber, Waleska Teixeira Caiaffa, Amélia Augusta de Lima Friche, Mariana Carvalho de Menezes, Gervásio Ferreira dos Santos, Isabel Cristina dos Santos, Letícia de Oliveira Cardoso, Ana V. Diez Roux,
Abstract Racial health inequities may be partially explained by area-level factors such as residential segregation. In this cross-sectional study, using a large, multiracial, representative sample of Brazilian adults (n = 37,009 individuals in the 27 state capitals; National Health Survey (Pesquisa Nacional de Saúde), 2013), we investigated 1) whether individual-level self-rated health (SRH) (fair or poor vs. good or better) varies by race (self-declared White, Brown, or Black) and 2) whether city-level ...
Tópico(s): Urban, Neighborhood, and Segregation Studies
2022 - Oxford University Press | American Journal of Epidemiology
Pedro M. Reis dos Santos, M. Isabel Reis dos Santos,
Tópico(s): Software Reliability and Analysis Research
2008 - Elsevier BV | European Journal of Operational Research
Produção Nacional
Revisado por pares
José Augusto Salim, Antônio Mauro Saraiva, Paula Zermoglio, Kayna Agostini, Marina Wolowski, Débora Pignatari Drucker, Filipi Miranda Soares, Pedro Joaquim Bergamo, Isabela Galarda Varassin, Leandro Freitas, M. M. Maués, André Rodrigo Rech, Allan Veiga, André Luís Acosta, Andréa Cardoso Araujo, Anselmo Nogueira, Betina Blochtein, Breno Magalhães Freitas, Bruno Albertini, Camila Maia-Silva, Carlos Eduardo Pereira Nunes, C. S. S. Pires, Charles Fernando dos Santos, Elisa Pereira Queiroz, Etienne A Cartolano, Favízia Freitas de Oliveira, Felipe Wanderley Amorim, Francisco E. Fontúrbel, Gleycon Velozo da Silva, Hélder Consolaro, Isabel Alves‐dos‐Santos, Isabel Cristina Machado, Juliana Saragiotto Silva, Kátia P Aleixo, Luísa G. Carvalheiro, Márcia A. Rocca, Mardiore Pinheiro, Michael Hrncir, Nathália Susin Streher, Patrícia Alves Ferreira, Patrícia Maia Correia de Albuquerque, Pietro K. Maruyama, Rafael Cabral Borges, Tereza Cristina Giannini, Vinícius Lourenço Garcia de Brito,
Animal pollination is an important ecosystem function and service, ensuring both the integrity of natural systems and human well-being. Although many knowledge shortfalls remain, some high-quality data sets on biological interactions are now available. The development and adoption of standards for biodiversity data and metadata has promoted great advances in biological data sharing and aggregation, supporting large-scale studies and science-based public policies. However, these standards are currently ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2022 - University of Oxford | GigaScience
Helen Strongman, Sarah Gadd, Anthony Matthews, Kathryn E. Mansfield, Susannah Stanway, Alexander R. Lyon, Isabel dos‐Santos‐Silva, Liam Smeeth, Krishnan Bhaskaran,
Cancer survivors have a higher risk for developing cardiovascular diseases than the general population.The aim of this study was to investigate whether cardiovascular mortality overtakes cancer-specific mortality during cancer survivorship and, if so, at what point cardiovascular disease becomes the dominant cause of death.This cohort study used linked English electronic health records, including death registration data. The study population included 104,028 adults ≥40 years of age whose first cancer ...
Tópico(s): Metabolism, Diabetes, and Cancer
2022 - Elsevier BV | JACC CardioOncology
Milena Foerster, Valerie McCormack, Benjamin O. Anderson, Pauline Boucheron, Annelle Zietsman, Herbert Cubasch, Maureen Joffe, Angelica A. Anele, Shadrach Offiah, Moses Galukande, Groesbeck P. Parham, Leeya F. Pinder, Ophira Ginsburg, Joachim Schüz, Isabel dos‐Santos‐Silva, Eva Johanna Kantelhardt,
Background Comprehensive breast cancer management is essential to achieve high breast cancer survival; however, detailed reports of the treatment regimens received by patients are scarce in sub-Saharan Africa where survival is low. We aimed to examine treatment initiation, guideline concordance, and abandonment in patients with non-metastatic breast cancer in sub-Saharan Africa from the African Breast Cancer–Disparities in Outcomes (ABC-DO) prospective cohort. Methods The ABC-DO prospective cohort ...
Tópico(s): Economic and Financial Impacts of Cancer
2022 - Elsevier BV | The Lancet Oncology
Florence Guida, Rachel Kidman, Jacques Ferlay, Joachim Schüz, Isabelle Soerjomataram, Benda Kithaka, Ophira Ginsburg, Raymond B. Mailhot Vega, Moses Galukande, Groesbeck P. Parham, Salvatore Vaccarella, Karen Canfell, André Ilbawi, Benjamin O. Anderson, Freddie Bray, Isabel dos‐Santos‐Silva, Valerie McCormack,
Despite women being disproportionally affected by cancer deaths at young ages, there are no global estimates of the resulting maternal orphans, who experience health and education disadvantages throughout their lives. We estimated the number of children who became maternal orphans in 2020 due to their mother dying from cancer in that year, for 185 countries worldwide and by cause of cancer-related death. Female cancer deaths-by country, cancer type and age (derived from GLOBOCAN estimates)-were multiplied ...
Tópico(s): Health and Conflict Studies
2022 - Nature Portfolio | Nature Medicine
Isabel dos‐Santos‐Silva, Sudeep Gupta, Jackson Orem, Lawrence N. Shulman,
Despite the significant advances made in our understanding of cancer and how to treat it over the last hundred years, there are wide global disparities in access to cancer care and in who gets to benefit from cutting-edge cancer research.
Tópico(s): Advances in Oncology and Radiotherapy
2022 - Nature Portfolio | Communications Medicine
Steady Chasimpha, Valerie McCormack, Herbert Cubasch, Maureen Joffe, Annelle Zietsman, Moses Galukande, Groesbeck P. Parham, Leeya F. Pinder, Angelica A. Anele, Charles Adisa, A.U. Offiah, Benjamin O. Anderson, Pauline Boucheron, Milena Foerster, Joachim Schüz, Isabel dos‐Santos‐Silva,
Studies have shown increased mortality among women living with HIV diagnosed with breast cancer compared with HIV-negative women with breast cancer. We aimed to examine how this HIV differential varies by patient or breast tumour characteristics.
Tópico(s): Cervical Cancer and HPV Research
2022 - Elsevier BV | The Lancet HIV
Hanla A. Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Adinda Baten, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Natalia Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Sara Y. Brucker, Barbara Burwinkel, Daniele Campa, Federico Canzian, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix‐Trench, Christine L. Clarke, Anne‐Lise Børresen‐Dale, Grethe I.G. Alnæs, Kristine Kleivi Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Drageset Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Don Conroy, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Miriam Dwek, Diana Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Lin Fritschi, Montserrat García‐Closas, José A. García‐Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mervi Grip, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny Han, Elaine F. Harkness, Steven N. Hart, Wei He, Bernadette A. M. Heemskerk‐Gerritsen, John L. Hopper, David J. Hunter, Christine L. Clarke, Deborah J. Marsh, Rodney J. Scott, Robert C. Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, J. Dinny Graham, Mythily Sachchithananthan, David J. Amor, Lesley Andrews, Yoland Antill, Rosemary L. Balleine, Jonathan Beesley, Ian Bennett, Michael Bogwitz, Leon Botes, Meagan Brennan, Melissa A. Brown, Michael F. Buckley, Jo Burke, Phyllis Butow, Liz Caldon, Ian Campbell, Deepa Chauhan, Manisha Chauhan, Georgia Chenevix‐Trench, Alice Christian, Paul A. Cohen, Alison Colley, Ashley Crook, James Cui, Margaret C. Cummings, Sarah‐Jane Dawson, Anna deFazio, Martin B. Delatycki, Rebecca Dickson, Joanne Dixon, Ted Edkins, Stacey L. Edwards, Gelareh Farshid, Andrew Fellows, Georgina Fenton, Michael Field, James M. Flanagan, Peter C.C. Fong, Laura Forrest, Stephen B. Fox, Juliet D. French, Michael Friedlander, Clara Gaff, Mike Gattas, Peter George, Sian Greening, Marion Harris, Stewart Hart, Nicholas K. Hayward, John L. Hopper, Cass Hoskins, Clare Hunt, Paul A. James, Mark A. Jenkins, Alexa Kidd, Judy Kirk, Jessica Koehler, James Kollias, Sunil R. Lakhani, Mitchell G. Lawrence, Geoffrey J. Lindeman, Lara Lipton, Liz Lobb, Graham J. Mann, Deborah J. Marsh, Sue Anne McLachlan, Bettina Meiser, Roger L. Milne, Sophie Nightingale, Shona O’Connell, Sarah O’Sullivan, David Gallego‐Ortega, Nick Pachter, Briony Patterson, Amy Pearn, Kelly‐Anne Phillips, Ellen Pieper, Edwina Rickard, Bridget A. Robinson, Mona Saleh, Elizabeth Salisbury, Christobel Saunders, Jodi M. Saunus, Rodney J. Scott, Clare L. Scott, Adrienne Sexton, Andrew N. Shelling, Peter T. Simpson, Melissa C. Southey, Amanda B. Spurdle, Jessica Taylor, Renea A. Taylor, Heather Thorne, Alison H. Trainer, Kathy Tucker, Jane E. Visvader, Logan C. Walker, Rachael Williams, Ingrid Winship, Mary Ann Young, Agnes Jager, Anna Jakubowska, Esther M. John, Audrey Jung, Rudolf Kaaks, Pooja Middha, Renske Keeman, Э. К. Хуснутдинова, Cari M. Kitahara, Linetta B. Koppert, Stella Koutros, Vessela N. Kristensen, Allison W. Kurian, James Lacey, Diether Lambrechts, Loı̈c Le Marchand, Wing‐Yee Lo, Jan Lubiński, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Marı́a Elena Martı́nez, Dimitrios Mavroudis, Thomas Ind, Usha Menon, Roger L. Milne, Taru Muranen, Heli Nevanlinna, William G. Newman, Børge G. Nordestgaard, Kenneth Offit, Andrew F. Olshan, Håkan Olsson, Tjoung‐Won Park‐Simon, Paolo Peterlongo, Julian Peto, Dijana Plaseska‐Karanfilska, Nadège Presneau, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Emmanouil Saloustros, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Lukas Schwentner, Christopher G. Scott, Mitul Shah, Xiao-Ou Shu, Jacques Simard, Ann Smeets, Melissa C. Southey, John J. Spinelli, Victoria L. Stevens, Anthony J. Swerdlow, Rulla M. Tamimi, William Tapper, Jack A. Taylor, Mary Beth Terry, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Elke M. van Veen, Joseph Vijai, Sophia Wang, Camilla Wendt, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton, Wei Zheng, Peter Kraft, Jenny Chang‐Claude,
Abstract Background Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of ...
Springer Nature | British Journal of Cancer
Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas U. Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heiko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Åke Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Brian D. Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Ophélie Bertrand, Sandrine M. Caputo, Anaïs Dupré, Marine Le Mentec, Muriel Belotti, Anne-Marie Birot, Bruno Buecher, Emmanuelle Fourme, Marion Gauthier-Villars, Lisa Golmard, Claude Houdayer, Virginie Moncoutier, Antoine de Pauw, Claire Saule, Olga Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Laure Barjhoux, Carole Verny-Pierre, Mélanie Léone, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Olivier Caron, Marine Guillaud-Bataille, Brigitte Bressac–de Paillerets, Yves- Jean Bignon, Nancy Uhrhammer, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Dominique Vaur, Laurent Castéra, Tetsuro Noguchi, Cornel Popovici, Hagay Sobol, Violaine Bourdon, Tetsuro Noguchi, Audrey Remenieras, Catherine Noguès, Isabelle Coupier, Pascal Pujol, Aurélie Dumont, Françoise Révillion, Claude Adenis, Danièle Muller, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Nicolas Sevenet, Michel Longy, Christine Toulas, Rosine Guimbaud, Laurence Gladieff, V. Feillel, Dominique Leroux, Hélène Dreyfus, Christine Rebischung, Magalie Peysselon, Fanny Coron, Laurence Faivre, Amandine Baurand, Caroline Jacquot, Geoffrey Bertolone, Sarab Lizard, Fabienne Prieur, Marine Lebrun, Caroline Kientz, Sandra Fert Ferrer, Véronique Mari, Laurence Vénat-Bouvet, Capucine Delnatte, Stéphane Bézieau, Isabelle Mortemousque, Florence Coulet, Chrystelle Colas, Florent Soubrier, Mathilde Warcoin, Johanna Sokolowska, Myriam Bronner, Marie‐Agnès Collonge‐Rame, Alexandre Damette, Paul Gesta, Hakima Lallaoui, Jean Chiésa, Denise Molina-Gomes, Olivier Ingster, Helen Gregory, Zosia Miedzybrodzka, Patrick J. Morrison, Kai-Ren Ong, Alan Donaldson, Mark T. Rogers, Michael J. Kennedy, Mary Porteous, Carole Brewer, Rosemarie Davidson, Louise Izatt, Angela Brady, Julian Barwell, Julian Adlard, Claire Foo, Fiona Lalloo, Lucy Side, Jacqueline Eason, Alex Henderson, Lisa Walker, Rosalind A. Eeles, Jackie Cook, Katie Snape, Diana Eccles, Alex Murray, Emma McCann, Margriet Collée, Don M. Conroy, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Dı́ez, Yuan Chun Ding, Susan M. Domchek, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Miriam Dwek, Diana Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago‐Dominguez, Susan M. Gapstur, Judy Garber, Vanesa Garcı́a, Montserrat García‐Closas, José A. García‐Sáenz, Mia M. Gaudet, Simon A. Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A. Harrington, Steven N. Hart, Wei He, Frans B. L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Darling J. Horcasitas, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, Stephen Fox, Ian Campbell, Amanda Spurdle, Penelope M. Webb, Anna de Fazio, Margaret Tassell, Judy Kirk, Geoffrey J. Lindeman, Melanie A. Price, Melissa C. Southey, Roger Milne, Sid Deb, David D.L. Bowtell, Annemieke H. van der Hout, Ans M.W. van den Ouweland, Arjen R. Mensenkamp, Carolien H. M. van Deurzen, Carolien M. Kets, Caroline Seynaeve, Christi J. van Asperen, Cora M. Aalfs, E. Gómez, Flora E. van Leeuwen, Geertruida H. de Bock, Hanne E. J. Meijers-Heijboer, Inge M. Obdeijn, Margriet Collée, J. J. P. Gille, Jan C. Oosterwijk, Juul Wijnen, Lizet E. van der Kolk, Maartje J. Hooning, Margreet G. E. M. Ausems, Marian J. E. Mourits, Marinus J. Blok, Matti A. Rookus, Muriel A. Adank, Rob B. van der Luijt, T. C. T. E. F. van Cronenburg, Carmen C. van der Pol, Nicola S. Russell, Sabine Siesling, Lucy Overbeek, Ruud Wijnands, Judith L. de Lange, Christine L. Clarke, Dinny Graham, Mythily Sachchithananthan, Deborah J. Marsh, Rodney J. Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, Agnes Jager, Anna Jakubowska, Paul A. James, Uffe Birk Jensen, Esther M. John, Michael E. Jones, R. Kaaks, Pooja Middha, Beth Y. Karlan, Renske Keeman, Э. К. Хуснутдинова, Johanna I. Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W. Kurian, Yael Laitman, Diether Lambrechts, L. Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adrià López‐Fernández, Jennifer T. Loud, Craig Luccarini,
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC ...
Nature Portfolio
Isabel dos Santos, Gurthwin Bosman, José Luis Aleixandre-Tudó, Wessel du Toit,
Phenolic compounds are secondary metabolites known to play crucial roles in important chemical reactions impacting the mouthfeel, colour and ageing potential of red wine. Their complexity has resulted in a number of advanced analytical methods, which often prevent routine phenolic analysis in winemaking. Fluorescence spectroscopy could be an alternative to current spectrophotometric techniques and its combination with chemometrics was investigated for its suitability in directly quantifying phenolic ...
Tópico(s): Spectroscopy and Chemometric Analyses
2021 - Elsevier BV | Talanta
Helian Feng, Alexander Gusev, Bogdan Paşaniuc, Lang Wu, Jirong Long, Zomoroda Abu-Full, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Antonis C. Antoniou, Aðalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Ella Asseryanis, Paul L. Auer, Jacopo Azzollini, Judith Balmañà, Rósa B. Barkardóttir, Daniel R. Barnes, Daniel Barrowdale, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Katarzyna Białkowska, Ana Blanco, Carl Blomqvist, Bram Boeckx, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Åke Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceño, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Sander Canisius, Daniele Campa, Brian D. Carter, Jonathan Carter, Jose E. Castelao, Jenny Chang‐Claude, Stephen J. Chanock, Hans Christiansen, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Kim De Leeneer, Joe Dennis, Peter Devilee, Orland Dı́ez, Susan M. Domchek, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Miriam Dwek, Diana Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Patricia A. Ganz, Susan M. Gapstur, Judy E. Garber, Montserrat García‐Closas, José Á. García-Sáenz, Mia M. Gaudet, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Christopher R. Hake, Wei He, Jane Heyworth, Frans B.L. Hogervorst, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Guanmengqian Huang, Peter J. Hulick, Keith Humphreys, Evgeny N. Imyanitov, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Rachel C. Jankowitz, Esther M. John, Nichola Johnson, Joseph Vijai, Audrey Jung, Beth Y. Karlan, Э. К. Хуснутдинова, Johanna I. Kiiski, Irene Konstantopoulou, Vessela N. Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lázaro, Dominique Leroux, Goska Leslie, Jenny Lester, Fabienne Lesueur, Noralane M. Lindor, Sara Lindström, Wing‐Yee Lo, Jennifer T. Loud, Jan Lubiński, Enes Makalic, Graham J. Mann, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, John W.M. Martens, Marı́a Elena Martı́nez, Laura Matricardi, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Pooja Middha, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna Marie Mulligan, Taru Muranen, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn Cilius Nielsen, Liene Ņikitina-Zaķe, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Håkan Olsson, Ana Osório, J. Papp, Tjoung‐Won Park‐Simon, Michael T. Parsons, Inge Søkilde Pedersen, Ana Peixoto, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Kelly‐Anne Phillips, Dijana Plaseska‐Karanfilska, Bruce Poppe, Nisha Pradhan, Karolina Prajzendanc, Nadège Presneau, Kevin Punie, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Harvey A. Risch, Mark E. Robson, Atocha Romero, Emmanouil Saloustros, Dale P. Sandler, Catarina Santos, Elinor J. Sawyer, Marjanka K. Schmidt, Daniel F. Schmidt, Rita K. Schmutzler, Minouk J. Schoemaker, Rodney J. Scott, Priyanka Sharma, Xiao‐Ou Shu, Jacques Simard, Christian F. Singer, Anne‐Bine Skytte, Penny Soucy, Melissa C. Southey, John J. Spinelli, Amanda B. Spurdle, Jennifer Stone, Anthony J. Swerdlow, William Tapper, Jack A. Taylor, Manuel R. Teixeira, Mary Beth Terry, Àlex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Rob A.�E.�M. Tollenaar, Diana Torres, Thérèse Truong, Nadine Tung, Celine M. Vachon, Christi J. van Asperen, Ans M.W. van den Ouweland, Elizabeth J. van Rensburg, Ana Vega, Alessandra Viel, Paula Vieiro‐Balo, Qin Wang, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Camilla Wendt, Robert Winqvist, Xiaohong R. Yang, Drakoulis Yannoukakos, Argyrios Ziogas, Roger L. Milne, Douglas F. Easton, Georgia Chenevix‐Trench, Wei Zheng, Peter Kraft, Xia Jiang,
Abstract Previous transcriptome‐wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome‐wide association studies (GWAS), but analyses of breast cancer subtype‐specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta‐analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER−). ...
Wiley | Genetic Epidemiology
Helena Carreira, Helen Strongman, Maria Peppa, Helen McDonald, Isabel dos‐Santos‐Silva, Susannah Stanway, Liam Smeeth, Krishnan Bhaskaran,
People with active cancer are recognised as at risk of COVID-19 complications, but it is unclear whether the much larger population of cancer survivors is at elevated risk. We aimed to address this by comparing cancer survivors and cancer-free controls for (i) prevalence of comorbidities considered risk factors for COVID-19; and (ii) risk of severe influenza, as a marker of susceptibility to severe outcomes from epidemic respiratory viruses.We included survivors (≥1 year) of the 20 most common cancers, ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2020 - Elsevier BV | EClinicalMedicine
Milena Foerster, Fiona McKenzie, Annelle Zietsman, Moses Galukande, Angelica A. Anele, Charles Adisa, Groesbeck P. Parham, Leeya F. Pinder, Joachim Schüz, Valerie McCormack, Isabel dos‐Santos‐Silva,
Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women recalled their diagnostic journey, including dates of first noticing symptoms and health-care provider (HCP) visits. Negative binomial regression models were used to identify correlates ...
Tópico(s): Colorectal Cancer Screening and Detection
2020 - Wiley | International Journal of Cancer
Fangfang Liu, Mengfei Liu, Ying Liu, Chuanhai Guo, Yunlai Zhou, Fenglei Li, Ruiping Xu, Zhen Liu, Qiuju Deng, Xiang Li, Chaoting Zhang, Yaqi Pan, Tao Ning, Xiao Dong, Zhe Hu, Huanyu Bao, Hong Cai, Isabel dos‐Santos‐Silva, Zhisong He, Yang Ke,
We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China. The oral microbiome was evaluated with 16S ribosomal RNA (rRNA) gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with ...
Tópico(s): Gastroesophageal reflux and treatments
2020 - AME Publishing Company | Chinese Journal of Cancer Research
Iris Kramer, Maartje J. Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W. Steyerberg, Daniele Giardiello, Antonis C. Antoniou, Paul D.P. Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L. Andrulis, Hoda Anton‐Culver, Kristan J. Aronson, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Hiltrud Brauch, Michael Bremer, Sara Y. Brucker, Barbara Burwinkel, Jose E. Castelao, Tsun Leung Chan, Jenny Chang‐Claude, Stephen J. Chanock, Georgia Chenevix‐Trench, Ji‐Yeob Choi, Christine L. Clarke, Margriet Collée, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Miriam Dwek, Diana Eccles, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Manuela Gago‐Dominguez, Montserrat García‐Closas, José A. García‐Sáenz, Graham G. Giles, David E. Goldgar, Anna González‐Neira, Christopher A. Haiman, Niclas Håkansson, Ute Hamann, Mikael Hartman, Bernadette A. M. Heemskerk‐Gerritsen, Antoinette Hollestelle, John L. Hopper, Ming‐Feng Hou, Anthony Howell, Hidemi Ito, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Esther M. John, Audrey Jung, Daehee Kang, C. Marleen Kets, Э. К. Хуснутдинова, Yon‐Dschun Ko, Vessela N. Kristensen, Allison W. Kurian, Ava Kwong, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Graham J. Mann, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Thomas Ind, Roger L. Milne, Anna Marie Mulligan, Taru Muranen, Susan L. Neuhausen, Heli Nevanlinna, William G. Newman, Andrew F. Olshan, Janet E. Olson, Håkan Olsson, Tjoung‐Won Park‐Simon, Julian Peto, Christos Petridis, Dijana Plaseska‐Karanfilska, Nadège Presneau, Katri Pylkäs, Paolo Radice, Gad Rennert, Atocha Romero, Rebecca Roylance, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Lukas Schwentner, Rodney J. Scott, Mee‐Hoong See, Mitul Shah, Chen‐Yang Shen, Xiao‐Ou Shu, Sabine Siesling, Susan Slager, Christof Sohn, Melissa C. Southey, John J. Spinelli, Jennifer Stone, William Tapper, Maria Tengström, Soo‐Hwang Teo, Mary Beth Terry, Rob A.�E.�M. Tollenaar, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Chantal Van Ongeval, Elke M. van Veen, Robert Winqvist, Alicja Wolk, Wei Zheng, Argyrios Ziogas, Douglas F. Easton, Per Hall, Marjanka K. Schmidt, Anne‐Lise Børresen‐Dale, Kristine Kleivi Sahlberg, Lars Ottestad, Rolf Kåresen, Ellen Schlichting, Marit Muri Holmen, Toril Sauer, Vilde Drageset Haakensen, Olav Engebråten, Bjørn Naume, Alexander Fosså, Cecile E. Kiserud, Kristin V. Reinertsen, Åslaug Helland, Margit Riis, Jürgen Geisler, Grethe Grenaker Alnæs, Christine L. Clarke, Deborah J. Marsh, Rodney J. Scott, Robert Baxter, Desmond Yip, Jane Carpenter, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, J. Dinny Graham, Mythily Sachchithananthan, David J. Amor, Lesley Andrews, Yoland Antill, Rosemary L. Balleine, Jonathan Beesley, Ian Bennett, Michael Bogwitz, Leon Botes, Meagan Brennan, Melissa A. Brown, Michael F. Buckley, Jo Burke, Phyllis Butow, Liz Caldon, Ian Campbell, Deepa Chauhan, Manisha Chauhan, Georgia Chenevix‐Trench, Alice Christian, Paul A. Cohen, Alison Colley, Ashley Crook, James Cui, Margaret C. Cummings, Sarah‐Jane Dawson, Anna deFazio, Martin Delatycki, Rebecca Dickson, Joanne Dixon, Ted Edkins, Stacey L. Edwards, Gelareh Farshid, Andrew Fellows, Georgina Fenton, Michael Field, James M. Flanagan, Peter C.C. Fong, Laura Forrest, Stephen B. Fox, Juliet D. French, Michael Friedlander, Clara Gaff, Mike Gattas, Peter George, Sian Greening, Marion Harris, Stewart Hart, Nicholas K. Hayward, John L. Hopper, Cass Hoskins, Clare Hunt, Paul A. James, Mark A. Jenkins, Alexa Kidd, Judy Kirk, Jessica Koehler, James Kollias, Sunil R. Lakhani, Mitchell G. Lawrence, Geoffrey J. Lindeman, Lara Lipton, Liz Lobb, Graham J. Mann, Deborah J. Marsh, Sue Anne McLachlan, Bettina Meiser, Roger L. Milne, Sophie Nightingale, Shona O’Connell, Sarah O’Sullivan, David Gallego‐Ortega, Nick Pachter, Briony Patterson, Amy Pearn, Kelly‐Anne Phillips, Ellen Pieper, Edwina Rickard, Bridget A. Robinson, Mona Saleh, Elizabeth Salisbury, Christobel Saunders, Jodi M. Saunus, Rodney J. Scott, Clare L. Scott, Adrienne Sexton, Andrew N. Shelling, Peter T. Simpson, Melissa C. Southey, Amanda B. Spurdle, Jessica Taylor, Renea A. Taylor, Heather Thorne, Alison H. Trainer, Kathy Tucker, Jane E. Visvader, Logan C. Walker, Rachael Williams, Ingrid Winship, Mary Ann Young,
Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC ...
Elsevier BV | The American Journal of Human Genetics
Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R. Barnes, Jamie Allen, Siddhartha Kar, Karen A. Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemaçon, Michael Lush, Jonathan P. Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomäki, M. Rosario Alonso, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Aðalgeir Arason, Volker Arndt, Kristan J. Aronson, Banu K. Arun, Bernd Auber, Paul L. Auer, Jacopo Azzollini, Judith Balmañà, Rósa B. Barkardóttir, Daniel Barrowdale, Alicia Beeghly‐Fadiel, Javier Benı́tez, Marina Bermisheva, Katarzyna Białkowska, Amie Blanco, Carl Blomqvist, William J. Blot, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Åke Borg, Kristin Bosse, Hiltrud Brauch, Hermann Brenner, Ignacio Briceño, Ian W. Brock, Angela Brooks‐Wilson, Thomas Brüning, Barbara Burwinkel, Saundra S. Buys, Qiuyin Cai, Trinidad Caldés, Maria A. Caligo, Nicola J. Camp, Ian Campbell, Federico Canzian, Jason S. Carroll, Brian D. Carter, Jose E. Castelao, Jocelyne Chiquette, Hans Christiansen, Wendy K. Chung, Kathleen Claes, Christine L. Clarke, Margriet Collée, Sten Cornelissen, Fergus J. Couch, Angela Cox, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Miguel de la Hoya, Peter Devilee, Orland Dı́ez, Yuan Chun Ding, Gillian S. Dite, Susan M. Domchek, Thilo Dörk, Isabel dos‐Santos‐Silva, Arnaud Droit, Stéphane Dubois, Martine Dumont, M. Durán, Lorraine Durcan, Miriam Dwek, Diana Eccles, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Giuseppe Floris, Henrik Flyger, Lenka Foretová, William D. Foulkes, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Manuela Gago‐Dominguez, Gaetana Gambino, Patricia A. Ganz, Susan M. Gapstur, Judy E. Garber, José Á. García-Sáenz, Mia M. Gaudet, V. Georgoulias, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González‐Neira, Maria Grazia Tibiletti, Mark H. Greene, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia Harrington, Jaana M. Hartikainen, Mikael Hartman, Wei He, Catherine S. Healey, Bernadette A. M. Heemskerk‐Gerritsen, Jane Heyworth, Peter Hillemanns, Frans B.L. Hogervorst, Antoinette Hollestelle, Maartje J. Hooning, John L. Hopper, Anthony Howell, Guanmengqian Huang, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Motoki Iwasaki, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Rachel C. Jankowitz, Esther M. John, Nichola Johnson, Michael E. Jones, Arja Jukkola‐Vuorinen, Audrey Jung, Rudolf Kaaks, Daehee Kang, Pooja Middha, Beth Y. Karlan, Renske Keeman, Michael J. Kerin, Э. К. Хуснутдинова, Johanna I. Kiiski, Judy Kirk, Cari M. Kitahara, Yon-Dschun Ko, Irene Konstantopoulou, Veli‐Matti Kosma, Stella Koutros, Katerina Kubelka‐Sabit, Ava Kwong, Kyriacos Kyriacou, Yael Laitman, Diether Lambrechts, Eunjung Lee, Goska Leslie, Jenny Lester, Fabienne Lesueur, Annika Lindblom, Wing‐Yee Lo, Jirong Long, Artitaya Lophatananon, Jennifer T. Loud, Jan Lubiński, Robert J. MacInnis, Tom Maishman, Enes Makalic, Graham J. Mann, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Keitaro Matsuo, Tabea Maurer, Dimitrios Mavroudis, Rebecca Mayes, Lesley McGuffog, Catriona McLean, Noura Mebirouk, Alfons Meindl, Austin Miller, Nicola Miller, Marco Montagna, Fernando Moreno, Kenneth Muir, Anna Marie Mulligan, Víctor M. Muñoz-Garzón, Taru Muranen, Steven A. Narod, Rami Nassir, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Finn Cilius Nielsen, Liene Ņikitina-Zaķe, Aaron D. Norman, Kenneth Offit, Edith Oláh, Olufunmilayo I. Olopade, Håkan Olsson, Nick Orr, Ana Osório, V. Shane Pankratz, J. Papp, Sue K. Park, Tjoung‐Won Park‐Simon, Michael T. Parsons, James Paul, Inge Søkilde Pedersen, Bernard Peissel, Beth N. Peshkin, Paolo Peterlongo, Julian Peto, Dijana Plaseska‐Karanfilska, Karolina Prajzendanc, Ross L. Prentice, Nadège Presneau, Darya Prokofyeva, Miquel Angel Pujana, Katri Pylkäs, Paolo Radice, Susan J. Ramus, Johanna Rantala, Rohini Rau‐Murthy, Gad Rennert, Harvey A. Risch, Mark E. Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Estela Sánchez‐Herrero, Dale P. Sandler, Marta Santamariña, Christobel Saunders, Elinor J. Sawyer, Maren T. Scheuner, Daniel F. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Ben Schöttker, Peter Schürmann, Christopher G. Scott, Rodney J. Scott, Leigha Senter, Caroline Seynaeve, Mitul Shah, Priyanka Sharma, Chen‐Yang Shen, Xiao-Ou Shu, Christian F. Singer, Thomas P. Slavin, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Amanda B. Spurdle, Jennifer Stone, Dominique Stoppa‐Lyonnet, Christian Sutter, Anthony J. Swerdlow, Rulla M. Tamimi, Yen Y. Tan, William Tapper, Jack A. Taylor, Manuel R. Teixeira, Maria Tengström, Soo‐Hwang Teo, Mary Beth Terry, Àlex Teulé, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz,
Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic ...
Nature Portfolio
Hongrui Tian, Wei Yang, Yan-Jun Hu, Zhen Liu, Lei Chen, Lei Liang, Fan Zhang, Fen Cai, Huawen Xu, Mengfei Liu, Chuanhai Guo, Yun Chen, Ping Xiao, Junhui Chen, Ping Ji, Zhengyu Fang, Fangfang Liu, Ying Liu, Yaqi Pan, Isabel dos‐Santos‐Silva, Zhisong He, Yang Ke,
We aimed to establish a Medical-Insurance-System-based Cancer Surveillance System (MIS-CASS) in China and evaluate the completeness and timeliness of this system through reporting cancer incidence rates using claims data in two regions in northern and southern China.We extracted claims data from medical insurance systems in Hua County of Henan Province, and Shantou City in Guangdong Province in China from Jan 1, 2012 to Jun 30, 2019. These two regions have been considered to be high risk regions ...
Tópico(s): Colorectal Cancer Screening and Detection
2020 - Elsevier BV | EClinicalMedicine
Kayo Togawa, Benjamin O. Anderson, Milena Foerster, Moses Galukande, Annelle Zietsman, Johanna Pontac, Angelica A. Anele, Charles Adisa, Groesbeck P. Parham, Leeya F. Pinder, Fiona McKenzie, Joachim Schüz, Isabel dos Santos‐Silva, Valerie McCormack,
Abstract We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer—Disparities in Outcomes (ABC‐DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda and Zambia. The baseline interview included information used to generate the geospatial features: urban/rural residence, travel mode to treatment facility and straight‐line distances from home to first‐care provider ...
Tópico(s): Data-Driven Disease Surveillance
2020 - Wiley | International Journal of Cancer
Valerie McCormack, Fiona McKenzie, Milena Foerster, Annelle Zietsman, Moses Galukande, Charles Adisa, Angelica A. Anele, Groesbeck P. Parham, Leeya F. Pinder, Herbert Cubasch, Maureen Joffe, Thomas Beaney, Manuela Quaresma, Kayo Togawa, Behnoush Abedi‐Ardekani, Benjamin O. Anderson, Joachim Schüz, Isabel dos‐Santos‐Silva,
BackgroundBreast cancer is the second leading cause of death from cancer in women in sub-Saharan Africa, yet there are few well characterised large-scale survival studies with complete follow-up data. We aimed to provide robust survival estimates in women in this setting and apportion the survival gaps.MethodsThe African Breast Cancer-Disparities in Outcomes (ABC-DO) prospective cohort study was done at eight hospitals across five sub-Saharan African countries (Namibia, Nigeria, South Africa, Uganda, ...
Tópico(s): Economic and Financial Impacts of Cancer
2020 - Elsevier BV | The Lancet Global Health
Isabel dos Santos Souza, Nawal Maïssa, Jason Ziveri, P. Morand, Mathieu Coureuil, Xavier Nassif, Sandrine Bourdoulous,
Neisseria meningitidis (meningococcus) is a Gram-negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Interaction with both peripheral and cerebral microvascular endothelial cells is at the heart of meningococcal pathogenesis. During the last two decades, an essential role for meningococcal type IV pili in vascular colonisation and disease progression has been unravelled. This review summarises 20 years of research on meningococcal type ...
Tópico(s): Pneumonia and Respiratory Infections
2020 - Wiley | Cellular Microbiology
Milena Foerster, Angelica A. Anele, Charles Adisa, Moses Galukande, Groesbeck P. Parham, Annelle Zietsman, Christopher Sule Oyamienlen, Kingsley Chukwunyere Iwuoha, Esther Ezeigbo, Evelyn Bakengesa, Agnes Kaggwa, Allen Naamala, Anne Nteziryayo, Teopista Nakazibwe, Leeya F. Pinder, Emily Walubita, Johanna Pontac, Benjamin O. Anderson, Fiona McKenzie, Joachim Schüz, Isabel dos‐Santos‐Silva, Valerie McCormack,
Accurate survival estimates are needed for guiding cancer control efforts in sub-Saharan Africa, but previous studies have been hampered by unknown biases due to excessive loss to follow-up (LTFU). In the African Breast Cancer-Disparities in Outcomes Study, a prospective breast cancer cohort study, we implemented active mobile health follow-up, telephoning each woman or her next-of-kin (NOK) trimonthly on her mobile phone to update information on her vital status. Dates of every contact with women/ ...
Tópico(s): Global Cancer Incidence and Screening
2020 - Oxford University Press | American Journal of Epidemiology
Moses Galukande, Joachim Schüz, Benjamin O. Anderson, Annelle Zietsman, Charles Adisa, Angelica A. Anele, Groesbeck P. Parham, Leeya F. Pinder, Mutumba Songiso, Dorothy Lombe, Anna Cabanes, Milena Foerster, Isabel dos‐Santos‐Silva, Valerie McCormack,
Low breast cancer survival in sub-Saharan Africa's young population increases the likelihood that breast cancer deaths result in maternal orphans, ie, children (<18 years) losing their mother.
Tópico(s): Cancer Risks and Factors
2020 - American Medical Association | JAMA Oncology
Kathryn E. Mansfield, Sigrún Alba Jóhannesdóttir Schmidt, Bianka Darvalics, Amy Mulick, Katrina Abuabara, Angel Wong, Henrik Toft Sørensen, Liam Smeeth, Krishnan Bhaskaran, Isabel dos‐Santos‐Silva, Richard J. Silverwood, Sinéad Langan,
Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases cancer risk and that immune stimulation increases cancer risk. Establishing baseline cancer risk in people with atopic eczema is important before exploring the association between new biologic drugs for atopic eczema and cancer risk.To investigate whether atopic eczema is associated with cancer.Matched cohort studies were conducted from January 2, 1998, to March 31, 2016, ...
Tópico(s): Herpesvirus Infections and Treatments
2020 - American Medical Association | JAMA Dermatology