Ryota Kurogi, Kunihiro Nishimura, Michikazu Nakai, Akiko Kada, Satoru Kamitani, Jyoji Nakagawara, Ḱazunori Toyoda, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Shinya Matsuda, Shinichi Yoshimura, Kazuo Okuchi, Akifumi Suzuki, Fumiaki Nakamura, Daisuke Onozuka, Keisuke Ido, Ai Kurogi, Nobutaka Mukae, Ataru Nishimura, Koichi Arimura, Takanari Kitazono, Akihito Hagihara, Koji Iihara, Masayoshi Takigami, Kenji Kamiyama, Kiyohiro Houkin, Shougo Nishi, Tetsuyuki Yoshimoto, Sadao Kaneko, Koji Oka, Yusuke Nakagaki, Hiroshi Ooyama, Kyousuke Kamada, Kenichi Makino, Naoki Tokumitsu, Kazuhiro Sako, Naoki Tokumitsu, Susumu Suzuki, Nozomi Suzuki, Teruo Kimura, Naoto Izumi, K. Nitta, Masahumi Ootaki, Masanori Isobe, Mikio NISHIYA, Takaaki Yamazaki, Syouji Mabuchi, Kuniaki Ogasawara, Naohiko Kubo, Yukihiko Shimizu, Keiichi Saito, Tatumi Yamanome, Akinori Yabuta, Akira Suzuki, Atsuo Yoshino, Junichi Harashina, Mitsuyuki Fujitsuka, Hiroyuki Masaoka, Masaaki Takami, Hirotoshi Ohtaka, Teruyuki Hirano, Y Shiokawa, Takaharu Okada, Ichirô Suzuki, Michihiro Kohno, Jou Haraoka, Yoshinori Arai, Noriyoshi Kawamura, Akira Isoshima, Masaharu Yasue, Mitsuhiko Hokari, Takayoshi Kobayashi, Kensuke Kawai, Taketoshi Maehara, Hajime Arai, Takakazu Kawamata, Yoshikazu Okada, Makoto Noguchi, Haruhiko Hoshino, Hirofumi Hiyama, Kensaku Yoshida, Mitsuyuki Fujitsuka, Osamu Utsugi, Yasuaki Takeda, Kouichi Tamaki, Hirohide Karasudani, Takao Urabe, Shiro Kobayashi, Michio Nakamura, Yorio Koguchi, Junichi Ono, Sumio Suda, Hiromu Hadeishi, Toshio Fukutake, Kenji Wakui, Hirokazu Tanno, Naoki Ishige, Takashi Ohasi, Naoaki Sato, Hideki Sakai, Yasuaki Nishimura, Takayuki Watanabe, Takashi Matsumoto, Naoki Koketsu, Yuichi Hirose, Manabu Doyu, Toshinori Hasegawa, Naoto Kuwayama, Shin-ichi Terao, Nobuhiko Mizutani, Noriyuki Suzaki, Satoshi Okuda, Keizo Yasui, Yukio Seki, Yasuhiro Hasegawa, Akira Ikeda, Youtarou Takeuchi, Sigeki Ohara, Yoshio Araki, Toshihiko Wakabayashi, Hisashi Tanaka, Junpei Yoshimoto, Makoto Sugiura, Koichiro Ogura, Nozomu Kobayashi, Toshio Yokoe, Kenichi Murao, Tomonori Yamada, Amami Kato, Toshiho Ohtsuki, Akatsuki Wakayama, Jun Takahashi, Hiroharu Kataoka, Toshiki Yoshimine, Yoshikazu Nakajima, Hidehuku Gi, Ryunosuke Uranishi, Yusaku Nakamura, Kazunori Yamanaka, Kazumi Ohmori, Hiroyuki Matsumoto, Yoshitugu Oiwa, Yosihiko Uemura, Hiroaki Fujiwara, Yoshiyasu Iwai, Masashi Morikawa, Kazuyuki Tane, Kazuo Hashikawa, Toshiyuki Fujinaka, Shunichi Yoneda, Kohsuke Yamashita, Masahiko Kitano, Shinsuke Tominaga, Kazuhito Nakamura, Katsuhiko Kono, Kenji Ohata, Hirokatsu Taniguchi, Takanori Hazama, Toshihiko Kuroiwa, Yoji Tamura, Kazusige Maeno, Motohiro Arai, Masaaki Iwase, Kenji Hashimoto, K. Yamada, Takashi Turuno, Tsutomu Ichinose, Shinichiro Kurokawa, Takeshi Matsuyama, Toshiaki Fujita, Takamichi Yuguchi, Yoshihumi Teramoto, Hiroto Kakita, Takayuki Matsuo, Tsuyoshi Izumo, Nobutoshi Ryu, Wataru Haraguchi, Naoki Kitagawa, Makio Kaminogo, Seisaburo Sakamoto, Yosiharu Tokunaga, Eiichirou Urasaki, Jun‐ichi Kuratsu, Akira Takada, Tadashi Terasaki, Toru Nishi, Isao Fuwa, Hisami Ooshima, Shigeo Yamashiro, Makoto Yoshikawa, Hiromasa Tsuiki, Kazunori Koga, Hiroshi Egami, Hirofumi Nagatomi, Tadao Kawamura, Makoto Goda, Y. Takeda, Kunihiko Mitsuo, Takamitu Hikawa, Masaki Morisige, Yuu Takeda, Yutaka Yamaguchi, Shiro Miyata, Shunro Uchinokura, Tomokazu Goya, Hideo Takeshima, Kazutaka Yatsushiro, Hajime Ohta, Tatsui Nagadou, Kazuho Hirahara, Souichi Obara, Hiroshi Seto, S. Tanaka, Koichi Moroki, Kazunori Arita, Shogo Ishiuchi, Toshimitsu Uchihara, Susumu Mekaru, Tomoaki Nagamine, Naoki Tomiyama, Jin Momoji, Satoshi Yamamoto, Koji Idomari, Atushi Kimoto, Tsutomu Kadekaru, Hirosi Syamoto, Osamu Sasaki, Makoto Minagawa, Yukihiko Fujii, Hideaki Takahashi, Kiyoshi Onda, Hiroyuki Arai, Shigekazu Takeuchi, Hiroshi Abe, Osamu Fukuda, Mitsuo Kouno, Tetsuro Tamura, Yukio Horie, Michiya Kubo, Hiroaki Hondo, Tadao Miyamori, Hisashi Takada, Toru Masuoka, Naoki Shirasaki, Hisashi Nitta, Makoto Kimura, Yasuo Katsuki, Yutaka Hayashi, Hisato Minamide, S Munemoto, Shunsuke Shiraga, Kiyonobu Ikeda, Mitsutoshi Nakada, Yutaka Hayashi, Syuji Sato, Taketo Hatano, Osamu Yamamura, Masanori Kabuto, Takahiro Sakuma, Jyunya Hayashi, Hiroyuki Kinouchi, Hidehito Koizumi, Mikito Uchida, Syougo Imae, Hiroshi Ozawa, Osamu Nishizaki, Manabu Fujita, Masakazu Suga, Shinji Iwata, Kanehisa Kohno, Takeharu Kunieda, Kiichiro Zenke, Mutsuo Fujisawa, Hiromichi Sadashima, Hikaru Mizobuchi, Satoru Hayashi, Masanori Morimoto, Takeshi Kohno, Tetsuya Ueba, Hiroyuki Nishimura, Naoki Ikawa, Yuzo Matsumoto, Seiji Kannuki, M Kagawa, Naoki Hayashi, Takashi Tamiya, Atsushi Shindo, Kimihiro Yoshino, Tetsuya Masaoka, Ichiro NAKAHARA, Akira Nakamizo, Yuji Okamoto,
Objectives This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. Methods We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) and were urgently hospitalized at 621 institutions in Japan between April 2010 and March 2015. We compared the DOAC- and warfarin-treated patients based on ...
Lippincott Williams & Wilkins
Hiroshi Abe, Yoshihiro Narusaka, Isao Sasaki, Katsunori Hatakeyama, S. Shini, Mari Narusaka, Kaoru Fukami-Kobayashi, Satoru Matsumoto, Masatomo Kobayashi,
Arabidopsis belongs to the Brassicaceae family and plays an important role as a model plant for which researchers have developed fine-tuned genome resources. Genome sequencing projects have been initiated for other members of the Brassicaceae family. Among these projects, research on Chinese cabbage (Brassica rapa subsp. pekinensis) started early because of strong interest in this species. Here, we report the development of a library of Chinese cabbage full-length cDNA clones, the RIKEN BRC B. rapa ...
Tópico(s): Genomics and Phylogenetic Studies
2011 - University of Oxford | DNA Research
Isao Sasaki, Nobutsugu Minami, Karthigeyan Annamalai, Konstantin Iakoubovskii,
We have prepared conductometric NO(2) gas sensors based on single-wall carbon nanotube (SWNT) networks. The SWNT properties are modified systematically by varying the annealing temperature between 350 to 550 degrees C under vacuum. Thermal annealing is not only necessary to remove dispersant used for nanotube dispersion but also plays an important role in optimizing the gas sensing abilities. In this paper, the sensing performance is evaluated through three crucial sensing characteristics: sensitivity ...
Tópico(s): Carbon Nanotubes in Composites
2008 - Royal Society of Chemistry | The Analyst
Isao Sasaki, Jiřı́ Janata, Mira Josowicz,
Stability of electronic parameters of conducting polymers affects the overall performance of organic electronics. We show that UV light (254 nm) treatment of polyaniline (PANI) films, containing camphorsulfonic acid (CSA) as a dopant and cast from formic acid, decreases the film resistance and keeps their improved resistance stable for at least 4 months. It has been found that due to the different origins of these electronic properties, the resistance and work function of the PANI·CSA films are affected ...
Tópico(s): Organic Electronics and Photovoltaics
2007 - Elsevier BV | Polymer Degradation and Stability
Keiichiro Oishi, Isao Sasaki, Junichi Otani,
The influence of additional elements on grain refinement of copper alloys was considered. It was found that the addition of silicon to Cu–Zn alloys increases number of nucleation sites, and the addition of minute amounts of cobalt to Cu–Zn–Si alloys inhibits grain growth. Exploiting these effects, a Cu–10Zn–2.0Si–0.1Co alloy with fine grains of approximately 1.6 μm was obtained. The increase in the number of nucleation sites is considered to be due to the decreasing stacking fault energy upon the ...
Tópico(s): Aluminum Alloy Microstructure Properties
2003 - Elsevier BV | Materials Letters
Isao Sasaki, Hiroshi Tsuchiya, Masateru Nishioka, Masayoshi Sadakata, Tatsuya Okubo,
Tópico(s): Gas Sensing Nanomaterials and Sensors
2002 - Elsevier BV | Sensors and Actuators B Chemical
Toshiko Nagashima, Fumie Sato, Takayo Chuma, Yukio Mano, Isao Sasaki, Masamitsu Mori, Toshio Higa, Nobuo Masauji, Masaharu Kasai, Yasuko Orba, Toshiya Shinohara, Kazuo Nagashima,
In recent years a novel problem has arisen in organ transplantation medicine, namely GVHD. The nervous system has been involved mainly at the level of the CNS and this can lead to a serious outcome for the patient. In rare cases, peripheral nerves may be affected and show acute or chronic polyneuropathy. Here a case is reported of polyneuropathy associated with chronic GVHD. A 32‐year‐old man, suffering from chronic GVHD following an allogeneic bone marrow transplantation (BMT) for malignant lymphoma ...
Tópico(s): Multiple Sclerosis Research Studies
2002 - Wiley | Neuropathology
T. Kiryu, Isao Sasaki, Keisuke Shibai, Keiji Tanaka,
We propose a unique fuzzy system design for adjusting the cycle ergometer work-load to each individual's physical work capacity. We observed the physical work capacity by measuring the heart rate and a muscular-fatigue-related index. A set of fuzzy membership functions was determined for three different phases during a trial of exercise with a progressively increasing workload. Since the available objective data was limited in describing changes in physical activities, the fuzzy rules for workload ...
Tópico(s): Ergonomics and Human Factors
2001 - IEEE Engineering in Medicine and Biology Society | IEEE Engineering in Medicine and Biology Magazine
Masatoshi Takahara, Toshihiko Ogino, Isao Sasaki, Hiroyuki Kato, Akio Minami, Kiyoshi Kaneda,
Long term outcome of osteochondritis dissecans of the humeral capitellum was determined for 53 patients. The average age of the patients at the time of treatment was 16.6 years (range, 10-34 years). The average followup was 12.6 years (range, 3-25 years). Seven of 14 (50%) patients who were treated conservatively and 18 of 39 (46%) who were treated by surgical removal of the fragment were found to have residual elbow symptoms associated with daily living activities (poor outcome). The initial radiographs ...
Tópico(s): Tendon Structure and Treatment
1999 - Lippincott Williams & Wilkins | Clinical Orthopaedics and Related Research
Mayuka Osada, Isao Sasaki, Masateru Nishioka, Masayoshi Sadakata, Tatsuya Okubo,
A faujasite thin layer is synthesized on a quartz crystal microbalance (QCM) with an Au electrode without seed crystals, and applied to a gas sensor. Faujasite synthesis is often accompanied by the production of zeolite P as a by-product, which would be an obstacle for gas sensing. Seed crystals tend to result in an irregular layer structure which is unfavorable in view of the stable oscillation of the QCM. In this study, therefore, the synthesis conditions (i.e. composition of the synthesis solution, ...
Tópico(s): Acoustic Wave Resonator Technologies
1998 - Elsevier BV | Microporous and Mesoporous Materials
Masatoshi Takahara, Isao Sasaki, Takumi Kimura, Hiroyuki Kato, Akio Minami, Toshihiko Ogino,
Nine children sustained a second fracture of the distal humerus after union of an ipsilateral supracondylar fracture which had healed with cubitus varus. There were eight boys and one girl with a mean age of five years (1 to 8) at the time of the second fracture which occurred at a mean of 1.5 years after the first. In all patients, the second fracture was an epiphyseal injury of the distal humerus, either associated with a fracture of the lateral metaphysis below the site of the previous supracondylar ...
Tópico(s): Shoulder Injury and Treatment
1998 - British Editorial Society of Bone & Joint Surgery | Journal of Bone and Joint Surgery - British Volume
Masatoshi Takahara, Isao Sasaki, T Kimura, Hiroyuki Kato, Akio Minami, T. Ogino,
Nine children sustained a second fracture of the distal humerus after union of an ipsilateral supracondylar fracture which had healed with cubitus varus. There were eight boys and one girl with a mean age of five years (1 to 8) at the time of the second fracture which occurred at a mean of 1.5 years after the first. In all patients, the second fracture was an epiphyseal injury of the distal humerus, either associated with a fracture of the lateral metaphysis below the site of the previous supracondylar ...
Tópico(s): Shoulder Injury and Treatment
1998 - British Editorial Society of Bone & Joint Surgery | Journal of Bone and Joint Surgery - British Volume
Isao Sasaki, Takashi Tamura, Tomoko Shibakawa, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi,
Tópico(s): Probiotics and Fermented Foods
1997 - Springer Science+Business Media | Pharmaceutical Research
Isao Sasaki, Kohichiro Tanaka, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Shozo Muranishi,
Intestinal absorption characteristics of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, were studied in rats by means of in situ closed loop and in vitro everted sac experiments. Plasma concentrations of azetirelin obtained in the in situ closed loop experiments were not significantly different among the intestinal segments. Area under the plasma concentration-time curve (AUC) of azetirelin following administration into the duodenal loop increased in proportion to the dose. The serosal ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
1995 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Isao Sasaki, Takuya Fujita, Masahiro Murakami, Akira Yamamoto, Eiji Nakamura, Hajime IMASAKI, Shozo Muranishi,
Absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, from the gastrointestinal (GI) tract was evaluated. The bioavailability of this compound after oral administration was considerably poor in rats. Studies were undertaken to elucidate the mechanisms for this low oral bioavailability of azetirelin. The plasma azetirelin levels following intravenous and hepatoportal vein injection were virtually identical over the dose range of 0.02-0.1 mg/kg, indicating a minor contribution ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
1994 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Yoshinobu Nakai, Keiji Yamamoto, Katsuhide Terada, Atsushi Kajiyama, Isao Sasaki,
The water vapor sorption isotherms have been established for α-, β-, and γ-cyclodextrin at 40°C. The powder X-ray diffraction patterns of crystal forms of cyclodextrins stored at various levels of relative humidity (RH) were examined and the results are discussed in terms of the hydration numbers. α-Cyclodextrin hydrate was stable at RH as low as 11%. The water vapor desorption isotherm of β-cyclodextrin showed pronounced hysteresis, which extended to lower RH.The hydrate form of β-cyclodextrin was ...
Tópico(s): Crystallization and Solubility Studies
1986 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Yasushi Endo, Hideki Fujimoto, Shinya Kumano, Yusuke Matsumura, Isao Sasaki, Yoshio Kawamura, Masahiko Yamamoto, Ryoichi Nakatani,
We have studied the details of the magnetization reversal process in Ni–Fe nanowires and dots using magnetic field sweeping (MFS)-magnetic force microscopy (MFM). All the points within the nanowire and the dot show important changes in phase (changes in stray field) including a hysteresis loop, a decrease and an increase in phase, as the magnetic field is varied. From these results, it is demonstrated that domain wall motion dominates the magnetization reversal process of a 10-nm-thick Ni–Fe nanowire ...
Tópico(s): Theoretical and Computational Physics
2008 - American Institute of Physics | Journal of Applied Physics
Isao Sasaki, Taichiro Imahori, Tatsuya Yano, Masanori Gomi, Junko Kuroda, Norikata Kobayashi, Kimitoshi Sato, Yoji Niwa, Koichi Iwasaki, Hiroshi Hasegawa,
Mechanical thrombectomy is highly effective for the recovery of acute ischemic stroke with large vessel occlusion. However, refractory occlusions are still encountered despite the use of currently available devices. In this article, we present a case of refractory terminal internal carotid artery occlusion treated with the "crossing double stent retriever technique." Two thrombectomy procedures with the combined technique using a stent retriever and aspiration catheter failed to recanalize the terminal ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2022 - Elsevier BV | Radiology Case Reports
YOSHINOBU NAKAI, KEIJI YAMAMOTO, KATSUHIDE TERADA, Isao Sasaki,
Effects of the amount of sorbed water on the solid-state crystallization of amorphous α-, β-, and γ-cyclodextrin (CD) were investigated. Water vapor adsorption isotherms were measured at 40°C for each amorphous CD which was prepared by the grinding in tungsten carbide vibrational mill. At higher relative humidities, the amorphous CDs converted to the carresponding crystal CD hydrates. X-Ray powder diffraction measurements were made after the samples reaehed the water vapor adsorption equilibrium. ...
Tópico(s): Rheology and Fluid Dynamics Studies
1986 - Pharmaceutical Society of Japan | YAKUGAKU ZASSHI
Y. Takeishi, Isao Sasaki, Kanji Hirabayashi,
Silicon atoms were evaporated onto cleaned and annealed Ge(111) surfaces at a rate of 2 × 1014 atoms/cm2 min up to 40 min. Analyses of LEED patterns have revealed, on the substrate at 870°K, truncated tetrahedra consisting of reconstructed {311} and (111) planes, which have a 3 × 1 and a 7 × 7 superstructure, respectively. The 3 × 1 superstructure was observed on cleaned and annealed Si(311) surfaces in an independent experiment.
Tópico(s): Chemical and Physical Properties of Materials
1967 - American Institute of Physics | Applied Physics Letters
Tatsuya Yano, Isao Sasaki, Kanako Kiyohara, Masahiko Kawanishi,
Objective: We report a case of stent fracture caused by an elongated styloid process, a form of Eagle syndrome.
Tópico(s): Linguistics and language evolution
2019 - | Journal of Neuroendovascular Therapy
Hiroyuki Yamasaki, Shunji Matsubara, Isao Sasaki, Shinji Nagahiro,
A 69-year-old man presented with a rare case of retinal artery embolization, which occurred as a complication of carotid angioplasty and carotid artery stenting performed for recurrent cerebral infarction. Magnetic resonance imaging and angiography showed right internal carotid artery stenosis with ulceration. Carotid angioplasty and carotid artery stenting were performed using the distal protection system with the PercuSurge GuardWire. However, just after dilation, the patient complained of ocular ...
Tópico(s): Retinal Imaging and Analysis
2009 - Japan Neurological Society | Neurologia medico-chirurgica
Tadahiro Takigawa, Shintaro Yoshii, Isao Sasaki, Kakuju Motoyama, Takashi Meguro,
Characteristics for electron beam emitted from <100>, <110> and <111> axial orientation LaB 6 cathodes after 100 hours of aging were studied. It is inferred from the emission pattern and cross-over image that electrons are emitted to a great extent from the top surface for the <100> cathode and mainly from the conical surface for <110> and <111> cathodes at a bias voltage that gives maximum brightness. This inference clearly explains the electron beam characteristics such as brightness, ...
Tópico(s): Nuclear Physics and Applications
1980 - Institute of Physics | Japanese Journal of Applied Physics
Fumio Ide, Isao Sasaki, Seiji Deguchi,
Abstract The grafting reactions of styrene (St), methyl methacrylate (MMA), and vinyl acetate (VAc) were investigated in the presence of n ‐butyl acrylate–acrylonitrile copolymer. Results showed that the nature of monomer and initiator were the major factors influencing the grafting activity. The grafting efficiency was 0.87 for St, 0.26 for MMA, and 0.18 for VAc under the most favorable conditions. Acrylic rubber reduced the rate of polymerization, and the retarding effect increased in the order St, ...
Tópico(s): Polymer Nanocomposites and Properties
1971 - Wiley | Journal of Applied Polymer Science
Isao Sasaki, Ji � Janata, Ari Glezer,
A miniature (millimeter-scale) synthetic jet actuator is integrated with a chemical gas sensor (chemFET) to effect inhalation and exhalation of ambient gas samples and induce small-scale mixing at the surface of the sensor. The fluidically integrated jet transports ambient fluid into the jet/sensor assembly through integrated fluid channels, impinges the sample fluid on the sensing element, and finally ejects the sample fluid to the ambient. The response of the sensor in the presence of the active ...
Tópico(s): Lattice Boltzmann Simulation Studies
2006 - IEEE Sensors Council | IEEE Sensors Journal
Moulid Hidayat, Yoichiro Mitsuishi, Fumiyuki Takahashi, Ken Tajima, Toshifumi Yae, Katsumi Miyahara, Daisuke Hayakawa, Wira Winardi, Hiroaki Ihara, Yoshika Koinuma, Aditya Wirawan, Fariz Nurwidya, Motoyasu Kato, Isao Kobayashi, Shinichi Sasaki, Kazuya Takamochi, Takuo Hayashi, Yoshiyuki Suehara, Mariko Moriyama, Hiroyuki Moriyama, Sonoko Habu, Kazuhisa Takahashi,
Several recent studies suggest that cancer stem cells (CSCs) are involved in intrinsic resistance to cancer treatment. Maintenance of quiescence is crucial for establishing resistance of CSCs to cancer therapeutics. F-box/WD repeat-containing protein 7 (FBXW7) is a ubiquitin ligase that regulates quiescence by targeting the c-MYC protein for ubiquitination. We previously reported that gefitinib-resistant persisters (GRPs) in EGFR-mutant non-small cell lung cancer (NSCLC) cells highly expressed octamer- ...
Tópico(s): Peptidase Inhibition and Analysis
2019 - Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina | Bosnian Journal of Basic Medical Sciences
Eiji Masai, Naofumi Kamimura, Daisuke Kasai, Akio Oguchi, Akiho Ankai, Shigehiro Fukui, Mikio Takahashi, Isao Yashiro, Hiroki Sasaki, Takeshi Harada, Sanae Nakamura, Y. Katano, Sachiko Narita-Yamada, Hidekazu Nakazawa, Hirofumi Hara, Yoshihiro Katayama, Masao Fukuda, Shuji Yamazaki, Nobuyuki Fujita,
Sphingobium sp. strain SYK-6 is able to grow on an extensive variety of lignin-derived biaryls and monoaryls, and the catabolic genes for these compounds are useful for the production of industrially valuable metabolites from lignin. Here we report the complete nucleotide sequence of the SYK-6 genome which consists of the 4,199,332-bp-long chromosome and the 148,801-bp-long plasmid.
Tópico(s): Microbial Natural Products and Biosynthesis
2011 - American Society for Microbiology | Journal of Bacteriology
Masanori Nojima, Reo Maruyama, Hiroshi Yasui, Hiromu Suzuki, Yumiko Maruyama, Isao Tarasawa, Yasushi Sasaki, Hideki Asaoku, Hajime Sakai, Toshiaki Hayashi, Mitsuru Mori, Kohzoh Imai, Takashi Tokino, Tadao Ishida, Minoru Toyota, Yasuhisa Shinomura,
Epigenetic changes such as DNA methylation play a key role in the development and progression of multiple myeloma. Our aim in the present study was to use genomic screening to identify genes targeted for epigenetic inactivation in multiple myeloma and assess their role in the development of resistance to dexamethasone.Gene expression was examined using microarray screening, reverse transcription-PCR, and real-time quantitative PCR. DNA methylation was examined using bisulfite PCR, bisulfite sequencing, ...
Tópico(s): Protein Degradation and Inhibitors
2009 - American Association for Cancer Research | Clinical Cancer Research
Masahide Takeda, Wataru Ito, Masako Tanabe, Shigeharu Ueki, Hikari Kato, Junko Kihara, Tomomi Tanigai, Takahito Chiba, Kazutoshi Yamaguchi, Hiroyuki Kayaba, Yumiko Imai, Kaori Okuyama, Isao Ohno, Takehiko Sasaki, Junichi Chihara,
Bronchial asthma is characterized by chronic airway inflammation caused by inflammatory cells. Phosphoinositide 3-kinases (PI3Ks) are known to play a prominent role in fundamental cellular responses of various inflammatory cells, including proliferation, differentiation, and cell migration. PI3Ks therefore are expected to have therapeutic potential for asthma. Although some investigations of the involvement between the pathogenesis of asthma and PI3K have been performed, it is unknown whether PI3Kgamma, ...
Tópico(s): Immune Cell Function and Interaction
2009 - Elsevier BV | Journal of Allergy and Clinical Immunology
Tomoko Aizawa, Nguyen Bao Ve, Ken-ichiro Kimoto, Noriyuki Iwabuchi, Hiroaki Sumida, Isao Hasegawa, Satohiko Sasaki, Tomohiko Tamura, Takuji Kudo, Ken‐ichiro Suzuki, Mutsuyasu Nakajima, Michio Sunairi,
The ammonia-producing bacteria B55 T , CA73, SA69 and SA72 were isolated from the waterweeds Ludwigia adscendens (B55 T ) and Eleocharis dulcis (CA73, SA69 and SA72) grown in highly acidic swamps (pH 2–4) in actual acid sulfate soil areas of Vietnam. The isolates were Gram-positive, irregular rod-shaped, non-spore-forming bacteria. On the basis of 16S rRNA gene sequence similarity, strain B55 T was shown to belong to the genus Curtobacterium of the class Actinobacteria . Chemotaxonomic data (MK-9 as major ...
Tópico(s): Microbial Natural Products and Biosynthesis
2007 - Microbiology Society | INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY