... Free Access ETHNOLINGUISTICS AND THE STUDY OF CULTURE ISMAEL SILVA-FUENZALIDA, ISMAEL SILVA-FUENZALIDA Universidad de Chile Santiago de ChileSearch for more papers by this author ISMAEL SILVA-FUENZALIDA, ISMAEL SILVA-FUENZALIDA Universidad de Chile Santiago de ChileSearch for ...
Tópico(s): Linguistic Variation and Morphology
1949 - Wiley | American Anthropologist
Produção Nacional
Revisado por pares
Paula J. Segura-Ramírez, Pedro Ismael Silva Júnior,
The remarkable ability of microorganisms to develop resistance to conventional antibiotics is one of the biggest challenges that the pharmaceutical industry currently faces. Recent studies suggest that antimicrobial peptides discovered in spider venoms may be useful resources for the design of structurally new anti-infective agents effective against drug-resistant microorganisms. In this work, we found an anionic antibacterial peptide named U₁-SCRTX-Lg1a in the venom of the spider Loxosceles gaucho. ...
Tópico(s): Beetle Biology and Toxicology Studies
2018 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Revisado por pares
Elisa Chaparro-Aguirre, Paula J. Segura-Ramírez, Flávio Lopes Alves, Karin A. Riske, Antônio Miranda, Pedro Ismael Silva Júnior,
One of the most important cellular events in arthropods is the moulting of the cuticle (ecdysis). This process allows them to grow until they reach sexual maturity. Nevertheless, during this stage, the animals are highly exposed to pathogens. Consequently, it can be assumed that arthropods counter with an efficient anti-infective strategy that facilitates their survival during ecdysis. Herein, we characterized a novel antimicrobial peptide called Pinipesin, present in the exuviae extract of the centipede ...
Tópico(s): Biochemical and Structural Characterization
2019 - Nature Portfolio | Scientific Reports
Robert P. Stockwell, J. Donald Bowen, Ismael Silva-Fuenzalida,
Tópico(s): Spanish Linguistics and Language Studies
1956 - Linguistic Society of America | Language
... Eduardo das Neves, Moreno, Donga, Pixinguinha, Brancura, and Ismael Silva are among the musicians discussed here. By interpreting ...
Tópico(s): Music History and Culture
2010 - Duke University Press | Hispanic American Historical Review
Produção Nacional
Ana Torres Schor, Filomena Marino Carvalho, Cláudio Kemp, Ismael Silva, José Russo,
Benign breast diseases represent the vast majority of diagnosis in breast pathology. However, the limited capability in identifying lesions at high risk of breast cancer evolution is an increasing problem in clinical practice. In the present study, we tested the hypothesis that the overexpression of S100P calcium-binding protein, previously identified in the very early stages of breast carcinogenesis, could be used as a marker to differentiate lesions at high risk of malignant evolution. In addition ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2006 - Elsevier BV | Oncology Reports
Produção Nacional
Ismael da Silva, Rene da Costa Vieira, C Stella, Edson Guimarães Loturco, André Lopes Carvalho, Carlos Augusto Rodrigues Véo, Cristovam Scapulatempo‐Neto, Sandra Monteiro Silva, Paulo D’Amora, Márcia Batista Salzgeber, Délcio Matos, Celso R. Silva, José Renato Assis Lemos Marques de Oliveira, Iara Baldim Rabelo, Patrícia Eiko Yamakawa, Rui M. B. Maciel, Rosa Paula M. Biscolla, Maria Izabel Chiamolera, Renato Fraietta, Felipe C.G. Reis, Marcelo A. Mori, Dirce Maria Lobo Marchioni, Antônio Augusto Ferreira Carioca, Gustavo Arantes Rosa Maciel, Renato Tomioka, Edmund Chada Baracat, Clóvis A. Silva, Celso Granato, R. S. Díaz, Bruno Scarpellini, Daniel Egle, Heidi Fiegl, Irmgard Himmel, Christina Troi, Robert A. Nagourney,
// Ismael da Silva 1, 2, 8 , Rene da Costa Vieira 8 , Carolina Stella 1 , Edson Loturco 6 , André Lopes ...
Tópico(s): Epigenetics and DNA Methylation
2018 - Impact Journals LLC | Oncotarget
Produção Nacional
Renata Miranda Lopes, Joseane Padilha da Silva, R. F. Vieira, Dijalma Barbosa da Silva, Ismael da Silva Gomes, Tânia da Silveira Agostini-Costa,
Dentre as fruteiras do Cerrado brasileiro com forte potencial para a exploração sustentada, encontram-se o araticum (Annona Crassiflora Mart.), o coquinho-azedo (Butia Capitata Mart.) e o pequi (Caryocar Brasiliense Camb.). O objetivo deste trabalho foi caracterizar o teor de óleo e o perfil de ésteres metílicos da fração lipídica da polpa dos frutos destas três espécies. Os teores de lipídeos foram determinados por extração contínua a quente com éter de petróleo em extrator tipo Soxhlet. O óleo para ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2012 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
Produção Nacional
Revisado por pares
Cibele Nicolaski Pedron, Marcelo D. T. Torres, Julia Aparecida da Silva Lima, Pedro Ismael da Silva, Fernanda Dias da Silva, Vani Xavier Oliveira,
Antimicrobial peptides are biologically active molecules produced by a wide range of organisms as an essential component of the innate immune response. They have recently attracted great interest, since they have antimicrobial activity against a broad spectrum of microorganisms. VmCT1 is a cationic peptide from the venom of Vaejovis mexicanus smithi scorpions, which presents antibacterial activity and tends to helical structures. Its analogs were synthesized, characterized and the conformational ...
Tópico(s): Chemical Synthesis and Analysis
2016 - Elsevier BV | European Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Marcelo D. T. Torres, Cibele Nicolaski Pedron, Julia Aparecida da Silva Lima, Pedro Ismael da Silva, Fernanda Dias da Silva, Vani Xavier Oliveira,
Linear cationic α‐helical antimicrobial peptides are promising chemotherapeutics. Most of them act by different mechanisms, making it difficult to microorganisms acquiring resistance. Decoralin is an example of antimicrobial peptide; it was described by Konno et al. and presented activity against microorganisms, but with pronounced hemolytic activity. We synthesized leucine‐substituted decoralin analogs designed based on important physicochemical properties, which depend on the maintenance of the ...
Tópico(s): Marine Sponges and Natural Products
2017 - Wiley | Journal of Peptide Science
Produção Nacional
Revisado por pares
Cibele Nicolaski Pedron, Cyntia Silva Oliveira, Adriana F. Silva, Gislaine Patricia Andrade, Maria Aparecida da Silva Pinhal, Giselle Cerchiaro, Pedro Ismael da Silva, Fernanda Dias da Silva, Marcelo D. T. Torres, Vani Xavier Oliveira,
Antimicrobial peptides (AMPs) are biologically active molecules with a broad-spectrum activity against a myriad of microorganisms. Aside from their antimicrobial functions, AMPs present physicochemical and structural properties that allow them to exert activity against other kind of cells, such as cancer cells. VmCT1 is a potent cationic amphipathic AMP from the venom of the scorpion Vaejovis mexicanus. In this study, we designed lysine-substituted VmCT1 analogs for verifying the influence of changes ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2019 - Elsevier BV | European Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Thomaz Augusto Alves da Rocha e Silva, Sandro Rostelato‐Ferreira, Gildo Bernardo Leite, Pedro Ismael da Silva, Stephen Hyslop, Léa Rodrigues‐Simioni,
Theraphosid spider venoms can block neurotransmission in vertebrate nerve-muscle preparations in vitro, but few of the components involved have been characterized. In this work, we describe the neuromuscular activity of venom from the Brazilian theraphosid Vitalius dubius and report the purification and pharmacological characterization of VdTX-1, a 728 Da toxin that blocks nicotinic receptors. Neuromuscular activity was assayed in chick biventer cervicis preparations and muscle responses to exogenous ...
Tópico(s): Ion channel regulation and function
2013 - Elsevier BV | Toxicon
Produção Nacional
Revisado por pares
Bruna S. da Silva, Andrea Díaz-Roa, Erica S. Yamane, Mirian A.F. Hayashi, Pedro Ismael da Silva,
Lactobacillus acidophilus are Gram-positive bacteria distributed in diverse environments, and as a component of the normal microbiota of gastrointestinal and urogenital tract, they are relevant for human beings. Classified as lactic acid bacteria, due to the production of lactic acid, Lactobacillus can also produce antimicrobial peptides (AMPs), which is a compound synthesized by all forms of life aiming for protecting themselves from threats and to increase their competitivity to survive in a specific ...
Tópico(s): Probiotics and Fermented Foods
2022 - Elsevier BV | Research in Microbiology
Juan Felipe Beltrán, Eduardo Núñez, Fernanda Nuñez, Ismael Silva, Tomas Bravo Tetlak, Ricardo Moffat,
Static strands response with asymmetric surface damage is studied.A nonlinear beam-based model is proposed to assess damaged strand response.Test data and 3D FE simulations validate the proposed nonlinear beam-based model.The nonlinear-based model is a robust and computationally cheap tool.
Tópico(s): Metal Forming Simulation Techniques
2018 - Elsevier BV | Construction and Building Materials
Karla F. Castro-Ochoa, Hilda Vargas‐Robles, Sandra D. Chánez-Paredes, Alfonso Felipe‐López, Rodolfo Ismael Cabrera-Silva, Mineko Shibayama, Abigail Betanzos, Porfirio Nava, Erwin A. Galinski, Michael Schnoor,
Tópico(s): Pharmacological Effects of Natural Compounds
2018 - Springer Science+Business Media | Digestive Diseases and Sciences
Produção Nacional
Revisado por pares
Andrea Díaz-Roa, Manuel A. Patarroyo, Felio Bello, Pedro Ismael da Silva,
Larval therapy (LT) is an alternative treatment for healing chronic wounds; its action is based on debridement, the removal of bacteria and stimulating granulation tissue. The most important mechanism when using LT for combating infection depends on larval excretions and secretions (ES). Larvae are protected against infection by a spectrum of antimicrobial peptides (AMPs); special interest in AMPs has also risen regarding understanding their role in wound healing since they degrade necrotic tissue ...
Tópico(s): Forensic Entomology and Diptera Studies
2018 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Rodrigo Pinheiro Araldi, Maristela Oliveira dos Santos, Fabiane Faria Barbon, Bruna Aparecida Manjerona, Bruno Rosa Meirelles, Pedro de Oliva Neto, Pedro Ismael da Silva, Lucinéia dos Santos, Isabel Cristina Cherici Camargo, Edislane Barreiros de Souza,
Brazilian Northeast is the world's largest producer of Agave sisalana Perrine for the supply of the sisal fiber. About 95% of plant biomass, which comprise the mucilage and sisal juice, is considered a waste residual is discarded in the soil. However, the sisal juice is rich in steroidal saponins, which exhibits different pharmacological properties. Despite this, natural products are not necessarily safe. Based on this, this study analyzed the antioxidant, cytotoxic and mutagenic potential of three ...
Tópico(s): Plant tissue culture and regeneration
2018 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Agustín G. Martinelli, Giorgio Basílici, Lucas E. Fiorelli, Carolina Klock, Joachim Karfunkel, Ariela Costa Diniz, Marcus Vinícius Theodoro Soares, André Marconato, João Ismael da Silva, Luiz Carlos Borges Ribeiro, Thiago da Silva Marinho,
We describe a globally rare example of a tetrapod burrow from the Upper Cretaceous Bauru Group (Bauru Basin) from Peirópolis, Minas Gerais State, Brazil. The sedimentary succession containing the burrow includes a rich vertebrate assemblage comprising fish, podocnemid turtles, mesoeucrocodylians, saurischian dinosaurs, among others. The burrow is composed of an oblique tunnel (~30°), oval in cross-section, with a horizontal and sub-oval terminal chamber; it is 1.3 m long from the midpoint of its inferred ...
Tópico(s): Ichthyology and Marine Biology
2019 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Produção Nacional
Revisado por pares
Thiago de Jesus Oliveira, Úrsula Castro de Oliveira, Pedro Ismael da Silva,
Antimicrobial peptides (AMPs) are small molecules, which have a potential use as antibiotic or pharmacological tools. In chelicerate organisms, such as scorpions, these molecules constitute an alternative defense system against microorganisms. The aim of this work was to identify AMPs in the hemolymph of the Tityus serrulatus scorpion. Fractions of plasma and hemocytes were subjected to high-performance liquid chromatography (HPLC) and then analyzed to determine their activity in inhibiting microbial ...
Tópico(s): Insect and Pesticide Research
2019 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Revisado por pares
Eliane Esteves, Bruna Bizzarro, Francisco B. Costa, Alejandro Ramírez‐Hernández, Ana Paula Ferranti Peti, Allan Henrique Depieri Cataneo, Pryscilla Fanini Wowk, Rodolfo Pessato Timóteo, Marcelo B. Labruna, Pedro Ismael da Silva, Célio Lopes Silva, Lúcia Helena Faccioli, Andréa Cristina Fogaça, Carlos A. Sorgi, Anderson Sá‐Nunes,
Amblyomma sculptum is an important vector of Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever and the most lethal tick-borne pathogen affecting humans. To feed on the vertebrate host's blood, A. sculptum secretes a salivary mixture, which may interact with skin resident dendritic cells (DCs) and modulate their function. The present work was aimed at depicting the A. sculptum saliva-host DC network and the biochemical nature of the immunomodulatory component(s) involved in this ...
Tópico(s): Mosquito-borne diseases and control
2019 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Caroline Dal Mas, Luana Rossato, Thaís Shimizu, Eduardo B. Oliveira, Pedro Ismael da Silva, Jacques F. Meis, Arnaldo Lopes Colombo, Mirian A.F. Hayashi,
Invasive Candida infections are an important growing medical concern and treatment options are limited to a few antifungal drug classes, with limited efficacies depending on the infecting organism. In this scenario, invasive infections caused by multiresistant Candida auris are emerging in several places around the world as important healthcare-associated infections. As antimicrobial peptides (AMPs) exert their activities primarily through mechanisms involving membrane disruption, they have a lower ...
Tópico(s): Biochemical and Structural Characterization
2019 - Multidisciplinary Digital Publishing Institute | Biomolecules
Produção Nacional
Revisado por pares
Andrea Díaz-Roa, Abraham Espinoza-Culupú, Orlando Torres, Monamaris Marques Borges, Ivan N. Avino, Flávio Lopes Alves, Antônio Miranda, Manuel A. Patarroyo, Pedro Ismael da Silva, Felio Bello,
Antibiotic resistance is at dangerous levels and increasing worldwide. The search for new antimicrobial drugs to counteract this problem is a priority for health institutions and organizations, both globally and in individual countries. Sarconesiopsis magellanica blowfly larval excretions and secretions (ES) are an important source for isolating antimicrobial peptides (AMPs). This study aims to identify and characterize a new S. magellanica AMP. RP-HPLC was used to fractionate ES, using C18 columns, ...
Tópico(s): Beetle Biology and Toxicology Studies
2019 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Moises S Martins Lopes, Larissa M. Machado, Pedro Alexandre Ismael Amaral Silva, Angel Ayumi Tome Uchiyama, Cheng Tzu Yen, Eliza Dalsasso Ricardo, Taciana Sousa Mutão, Jefferson R Pimento, Denis S Shimba, Rodrigo de Morais Hanriot, Renta D Peixoto,
Antibiotics have been extensively used to treat infectious diseases over the past century and have largely contributed to increased life expectancy over time.However, antibiotic use can impose profound and protracted changes to the diversity of the microbial ecosystem, affecting the composition of up to 30% of the bacterial species in the gut microbiome.By modifying human microbiota composition, antibiotics alter the action of several oncologic drugs, potentially leading to decreased efficacy and ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2020 - Cancer Intelligence | ecancermedicalscience
Produção Nacional
Revisado por pares
Guilherme A. Câmara, Milton Yutaka Nishiyama, Eduardo S. Kitano, Úrsula Castro de Oliveira, Pedro Ismael da Silva, Inácio L.M. Junqueira-de-Azevedo, Alexandre K. Tashima,
The Araneae order is considered one of the most successful group among venomous animals in the world. An important factor for this success is the production of venoms, a refined biological fluid rich in proteins, short peptides and cysteine-rich peptides (CRPs). These toxins may present pharmacologically relevant biological actions, as antimicrobial, antiviral and anticancer activities, for instance. Therefore, there is an increasing interest in the exploration of venom toxins for therapeutic reasons, ...
Tópico(s): Biochemical and Structural Characterization
2020 - Frontiers Media | Frontiers in Pharmacology
... 1139/Z09-111Rogério Bertani, Caroline Sayuri Fukushima, Pedro Ismael da Silva Júnior Mating behavior of Sickius longibulbi (Araneae, Theraphosidae, ...
Tópico(s): Insect and Arachnid Ecology and Behavior
1928 - University of Chicago Press | The Quarterly Review of Biology
Produção Nacional
Revisado por pares
Rogério Bertani, Pedro Ismael da Silva,
The monotypic Brazilian genus Sickius Soares & Camargo 1948 is revalidated, rediagnosed, and tentatively transferred to the Ischnocolinae. The formerly unknown female of S. longibulbi Soares & Camargo 1948 is found to lack spermathecae. This unusual genital feature, not found in any other mygalomorph spider species, is described and discussed.
Tópico(s): Hymenoptera taxonomy and phylogeny
2002 - American Arachnological Society | Journal of Arachnology
Produção Nacional
Revisado por pares
Daniel M. Lorenzini, Aline H. Fukuzawa, Pedro Ismael da Silva, Gláucia Maria Machado‐Santelli, A. Tania Bijovsky, Sirlei Daffre,
Tópico(s): Aquaculture disease management and microbiota
2003 - Elsevier BV | Insect Biochemistry and Molecular Biology
Produção Nacional
Revisado por pares
Daniel M. Lorenzini, Pedro Ismael da Silva, Andréa Cristina Fogaça, Philippe Bulet, Sirlei Daffre,
We report the isolation of a novel antimicrobial peptide, acanthoscurrin, from the hemocytes of unchallenged tarantula spider Acanthoscurria gomesiana. A combination of Edman degradation, mass spectrometry and cDNA cloning revealed the presence of two isoforms of acanthoscurrin, differing by two glycine residues. Both displayed cationic properties and a high percentage of glycine residues. However, acanthoscurrins have no structural similarities with already known glycine-rich antimicrobial peptides ...
Tópico(s): Insect Resistance and Genetics
2003 - Elsevier BV | Developmental & Comparative Immunology
Produção Nacional
Revisado por pares
P. Serafini, André Monteiro da Rocha, Cynthia Aparecida Bueno de Toledo Osório, Ismael da Silva, E.L.A. Motta, Edmund Chada Baracat,
To determine whether there is an association between endometrial expression of leukemia inhibitory factor (LIF) in the luteal phase of the menstrual cycle preceding in vitro fertilization (IVF) and treatment outcome.Biopsy specimens from the endometria of 52 women in the luteal phase were immunostained against LIF. Embryo culture and transfer were done according to standard procedures.Clinical pregnancy occurred in 39% of the women following IVF, and strong endometrial immunohistochemical staining ...
Tópico(s): Gynecological conditions and treatments
2008 - Elsevier BV | International Journal of Gynecology & Obstetrics
Produção Nacional
Revisado por pares
Rogério Bertani, Caroline Sayuri Fukushima, Pedro Ismael da Silva,
Two new species of Pamphobeteus Pocock 1901 are described from Brazil: Pamphobeteus crassifemur sp. nov. and Pamphobeteus grandis sp. nov.; Pamphobeteus nigricolor, formerly described from Colombia, Ecuador and Bolivia, is recorded from Brazil and its distribution in Ecuador and Bolivia is questioned. A new type of stridulatory organ is described from legs III and IV of P. crassifemur sp. nov. The structure consists of spiniform setae. Stridulation occurs when the spider moves the legs III and IV, ...
Tópico(s): Orthoptera Research and Taxonomy
2008 - Q15088586 | Zootaxa