Luis Cruz-Piris, Iván Marsá-Maestre, Miguel A. Lopez‐Carmona,
The problems related to traffic coordination in intersections are quite common in large cities. Current solutions are based on the utilization of static priorities (i.e. yield signs), on variable signaling like traffic lights, or even on the physical modification of the road structures by transforming intersections in roundabouts. The emergence, evolution, and consolidation of technologies that enable the paradigm of connected and autonomous vehicles have allowed the development of new solutions ...
Tópico(s): Autonomous Vehicle Technology and Safety
2019 - Institute of Electrical and Electronics Engineers | IEEE Access
Miguel Piris‐Villaespesa, Iván Álvarez‐Twöse,
Systemic mastocytosis is a rare and heterogeneous disease characterized by mast cell proliferation and activation. KIT is a transmembrane tyrosine kinase which plays a key role in mast cell growth, differentiation and survival. After interaction with its ligand, the stem cell factor, KIT dimerizes activating downstream pathways involving multiple tyrosine kinases (PI3K, JAK/STAT, RAS/ERK). Activating mutations in KIT are detected in most cases of systemic mastocytosis, being the most common KIT D816V. ...
Tópico(s): Eosinophilic Disorders and Syndromes
2020 - Frontiers Media | Frontiers in Pharmacology
Luis Cruz-Piris, Diego Rivera, Iván Marsá-Maestre, Enrique de la Hoz, Juan R. Velasco,
Internet growth has generated new types of services where the use of sensors and actuators is especially remarkable. These services compose what is known as the Internet of Things (IoT). One of the biggest current challenges is obtaining a safe and easy access control scheme for the data managed in these services. We propose integrating IoT devices in an access control system designed for Web-based services by modelling certain IoT communication elements as resources. This would allow us to obtain ...
Tópico(s): Vehicular Ad Hoc Networks (VANETs)
2018 - Multidisciplinary Digital Publishing Institute | Sensors
Susel Fernández, Takayuki Itō, Luis Cruz-Piris, Iván Marsá-Maestre,
Intelligent transportation systems encompass a series of technologies and applications that exchange information to improve road traffic and avoid accidents. According to statistics, some studies argue that human mistakes cause most road accidents worldwide. For this reason, it is essential to model driver behavior to improve road safety. This paper presents a Fuzzy Rule-Based System for driver classification into different profiles considering their behavior. The system’s knowledge base includes ...
Tópico(s): Traffic Prediction and Management Techniques
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Luis Cruz-Piris, Miguel A. Lopez‐Carmona, Iván Marsá-Maestre,
Traffic jams in large cities, in addition to having a very high economic cost, cause an increase in emissions generated by vehicles over the same route being driven under normal conditions. In recent years, there has been a rapid evolution in the technologies applied to the field of autonomous vehicles. There are currently commercial solutions for assisted driving and semi-autonomous driving systems, with very favorable forecasts for reaching a completely autonomous vehicle scenario in the coming ...
Tópico(s): Vehicle Dynamics and Control Systems
2019 - Institute of Electrical and Electronics Engineers | IEEE Access
Luis Cruz-Piris, Diego Rivera, Susel Fernández, Iván Marsá-Maestre,
One of the biggest challenges in modern societies is to solve vehicular traffic problems. Sensor networks in traffic environments have contributed to improving the decision-making process of Intelligent Transportation Systems. However, one of the limiting factors for the effectiveness of these systems is in the deployment of sensors to provide accurate information about the traffic. Our proposal is using the centrality measurement of a graph as a base to locate the best locations for sensor installation ...
Tópico(s): Traffic Prediction and Management Techniques
2018 - Multidisciplinary Digital Publishing Institute | Sensors
Zijun Y. Xu‐Monette, Hongwei Zhang, Feng Zhu, Alexandar Tzankov, Govind Bhagat, Carlo Visco, Karen Dybkær, April Chiu, Wayne Tam, Youli Zu, Eric D. Hsi, Hua You, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael Møller, Benjamin M. Parsons, J. Han van Krieken, Miguel Á. Piris, Jane N. Winter, Fredrick B. Hagemeister, Babak Shahbaba, Ivan De Dios, Hong Zhang, Yong Li, Bing Xu, Maher Albitar, Ken H. Young,
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity of B-cell lymphoma. Cell-of-origin (COO) classification of DLBCL is required in routine practice by the World Health Organization classification for biological and therapeutic insights. Genetic subtypes uncovered recently are based on distinct genetic alterations in DLBCL, which are different from the COO subtypes defined by gene expression signatures of normal B cells retained in DLBCL. We hypothesize that classifiers incorporating both ...
Tópico(s): CAR-T cell therapy research
2020 - Elsevier BV | Blood Advances
Iván Barrios, V Miltos, Álvaro Parrela Píris, Guillem Piris, Carlos Ramírez, J Rodríguez, Júlio Torales, G Rodríguez Andersen, Andrés Arce,
INTRODUCCIÓN:Los estudiantes de medicina están expuestos a un mayor número de trastornos mentales que los de la población general por las exigencias propias de la carrera, resaltan entre estos trastornos los de ansiedad y depresión cuyos valores son superiores a los encontrados en la población general.La Mini International Neuropsychiatric Interview (MINI) es una entrevista breve y altamente estructurada de los principales trastornos psiquiátricos del CIE-10.SUJETOS Y MÉTODOS: Fue un estudio observacional ...
Tópico(s): Health and Medical Education
2016 - Facultad de Ciencias Médicas de la Universidad Nacional de Asunción | Anales de la Facultad de Ciencias Médicas (Asunción)
Juan Felipe Huan Lew-Yee, Iván Alejandro Bonfil-Rivera, Mario Piris, Jorge M. del Campo,
In this work, we explore the use of Piris natural orbital functionals (PNOFs) to calculate excited-state energies by coupling their reconstructed second-order reduced density matrix with the extended random-phase approximation (ERPA). We have named the general method PNOF-ERPA, and specific approaches are referred to as PNOF-ERPA0, PNOF-ERPA1, and PNOF-ERPA2, according to the way the excitation operator is built. The implementation has been tested in the first excited states of H2, HeH+, LiH, Li2, ...
Tópico(s): Quantum, superfluid, helium dynamics
2024 - American Chemical Society | Journal of Chemical Theory and Computation
Jon M. Matxain, Fernando Ruipérez, Ivan Infante, Xabier López, Jesús M. Ugalde, Gabriel Merino, Mario Piris,
The natural orbital functional theory admits two unique representations in the orbital space. On the one hand, we have the natural orbitals themselves that minimize the energy functional, and which afford for a diagonal one-particle reduced density matrix but not for a diagonal Lagrangian orbital energy multipliers matrix. On the other hand, since it is possible to reverse the situation but only once the energy minimization has been achieved, we have the so-called canonical representation, where ...
Tópico(s): Synthesis and characterization of novel inorganic/organometallic compounds
2013 - American Institute of Physics | The Journal of Chemical Physics
Marino Tejedor‐Romero, José Manuel Giménez-Guzmán, David Herranz-Oliveros, Luis Cruz-Piris, Iván Marsá-Maestre,
Tópico(s): Advanced Wireless Network Optimization
2024 - Springer Science+Business Media | Lecture notes in computer science
Larissa Haertle, Hipolito Nicolas Cuesta Hernández, Natalia Sofia Buenache, Michal Šimíček, Renáta Šnaurová, Inmaculada Rapado, Nerea Martı́nez, Nieves López‐Muñoz, José María Sánchez‐Pina, Rafael Colmenares, Margarita Sánchez‐Beato, Miguel Á. Piris, Iván Plaza-Menacho, Mehmet Samur, Nikhil C. Munshi, Rosa Ayala, K. Martin Kortuem, Santiago Barrio, Joaquín Martínez‐López,
Background For the treatment of Multiple Myeloma (MM), proteasome inhibitors (PIs) are highly efficient and widely used, but resistance is a major obstacle to successful therapy. Several underlying mechanisms have been proposed but were only reported for a minority of resistant patients e.g., mutations in the PI binding domain PSMB5. However, the proteasome is a large and complex machinery and its mechanistic understanding remains incomplete. In this study, we unravel the role of the six ATPases of ...
Tópico(s): Peptidase Inhibition and Analysis
2022 - Elsevier BV | Blood
Produção Nacional
Revisado por pares
Iván Barrios, Adriana Piris-Jara, Miguel Ángel Montiel-Alfonso, Carlos Miguel Ríos-González, Diego Solís-Ávalos, Òscar García, Rodrigo Navarro, Israel González, Marcelo O’Higgins, Osvaldo Melgarejo, José Almirón‐Santacruz, Noelia Ruíz Diáz, Jorge Villalba-Arias, João Maurício Castaldelli-Maia, Antonio Ventriglio, Júlio Torales,
Introducción: los trastornos alimentarios y de la ingestión de alimentos están asociados con importantes efectos físicos y morbilidad psicosocial, así como con un impacto negativo en la calidad de vida de las personas.
Tópico(s): Eating Disorders and Behaviors
2021 - Facultad de Ciencias Médicas de la Universidad Nacional de Asunción | Revista del Nacional (Itaguá)
José Manuel Giménez-Guzmán, Iván Marsá-Maestre, Luis Cruz-Piris, David Orden, Marino Tejedor‐Romero,
There are several recent research lines addressing Wi-Fi network planning and optimization, both in terms of channel assignment and access point deployment. The problem with these works is that evaluation is usually performed with specific and closed models regarding signal propagation, throughput computation, and utility definition. Also, many of the models in the literature make assumptions about the role of wireless stations, or the co-channel interference, which -while being valid in the context ...
Tópico(s): Advanced Wireless Network Optimization
2022 - Elsevier BV | Alexandria Engineering Journal
Produção Nacional
Revisado por pares
Júlio Torales, Iván Barrios, Jazmín Barrios, Hernando Báez-Osorio, Enrique Sánchez-Piris, Edis Ortigoza-Alves, Jorge Villalba-Arias, Noelia Ruíz Diáz, Marcelo O’Higgins, Diego Amarilla, José Almirón‐Santacruz, Tomás Caycho‐Rodríguez, João Maurício Castaldelli-Maia, Antonio Ventriglio, Red de Estudiantes Investigadores en Neurociencias,
Introducción: los estudiantes de medicina son vulnerables al malestar psicológico y se enfrentan a una serie de factores estresantes como las presiones académicas, las preocupaciones económicas y las dificultades en las relaciones interpersonales. La calidad de su formación educativa también puede influir en su salud mental y bienestar subjetivo. Este fue un estudio descriptivo, transversal y observacional que incluyó estudiantes de medicina de la Universidad Nacional de Asunción, Campus Santa Rosa ...
Tópico(s): Healthcare professionals’ stress and burnout
2023 - Facultad de Ciencias Médicas de la Universidad Nacional de Asunción | Medicina Clínica y Social
Marino Tejedor‐Romero, José Manuel Giménez-Guzmán, Luis Cruz-Piris, David Herranz-Oliveros, Iván Marsá-Maestre,
Channel assignment in Wi-Fi 6 dense networks is a challenging problem which critically impacts the performance of WLAN communications. Although there have been many proposals in the area of IEEE 802.11 channel assignment, LCCS has emerged as the de facto standard for distributed channel selection. Notwithstanding, centralized optimizers overcome the performance of distributed channel assignment algorithms, so their study is of utmost importance. One of the most successful optimization proposals ...
Tópico(s): Wireless Communication Networks Research
2024 - Elsevier BV | Engineering Science and Technology an International Journal
Maher Albitar, Xu‐Monette Y Zijun, Yingjun Wang, Deng Manman, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Karen Dybkær, Wayne Tam, Eric D. Hsi, Maurilio Ponzoni, Andrés JM Ferreri, Michael Møller, Miguel Á. Piris, J. Han van Krieken, Ivan De Dios, Youli Zu, Jane N. Winter, Hagop M. Kantarjian, Yong Li, Ken H. Young,
Introduction: RNA expression profiling using Next Generation Sequencing (NGS) provides important and reproducible information on expression levels of various genes. We studied the expression levels of MYC and BCL2 in patients with diffuse large B-Cell lymphoma (DLBCL) using NGS targeted RNA sequencing. We correlated levels of expression of these genes with outcome. Methods: RNA extracted from 441 FFPE samples with DLBC lymphoma and sequenced targeting 1408 genes. The RNA sequencing is based on hybrid ...
Tópico(s): Cancer-related gene regulation
2019 - Elsevier BV | Blood
L. Franco, Roberto Rojas-Hernández, Iván Alejandro Bonfil-Rivera, Emilio Orgaz, Jorge M. del Campo,
Tópico(s): Catalysis and Oxidation Reactions
2025 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Karen Zárate, Adriana Piris, Jesús Ferreira, Júlio Torales, Iván Barrios,
Introducción: Las infecciones del tracto urinario, definidos como un proceso inflamatorio de invasión y multiplicación de microorganismos en el tracto urinario, son las infecciones más frecuentes luego de las respiratorias y la segunda causa de prescripción antibiótica. Múltiples estudios han demostrado que se solicitan análisis de orina en ausencia de signos o síntomas de ITU, lo cual nos llevaría al sobrediagnostico y al uso indiscriminado de antibióticos Metodología: Es un estudio observacional, ...
Tópico(s): Urinary Tract Infections Management
2023 - | ScientiAmericana Revista Multidisciplinaria
Iván Marsá-Maestre, José Manuel Giménez-Guzmán, Luis Cruz-Piris, Susel Fernández, José-Javier Martínez-Herráiz, Bernardo Alarcos, Iván Blanco-Chacón,
Made in Spain (E.U.)
Tópico(s): Software System Performance and Reliability
2021 - | Colección Jornadas y congresos
Antonio J. Romero-Barrera, Luis Cruz-Piris, Marino Tejedor‐Romero, José Manuel Giménez-Guzmán, Iván Marsá-Maestre,
Tópico(s): Advanced MIMO Systems Optimization
2024 - Institute of Electrical and Electronics Engineers | IEEE Access
L. Franco, Iván Alejandro Bonfil-Rivera, Juan Felipe Huan Lew-Yee, Mario Piris, Jorge M. del Campo, Rodrigo A. Vargas–Hernández,
Within the framework of natural orbital functional theory, having a convenient representation of the occupation numbers and orbitals becomes critical for the computational performance of the calculations. Recognizing this, we propose an innovative parametrization of the occupation numbers that takes advantage of the electron-pairing approach used in Piris natural orbital functionals through the adoption of the softmax function, a pivotal component in modern deep-learning models. Our approach not ...
Tópico(s): Advanced Chemical Physics Studies
2024 - American Institute of Physics | The Journal of Chemical Physics
Iván Barrios, C Wildberger Ramirez, Adriana Piris, Marcelo Toñánez, Margarita Samudio, Júlio Torales,
descriptivo, de corte transversal, realizado en 65 estudiantes del 1º
Tópico(s): Health and Lifestyle Studies
2016 - Universidad Nacional de Asunción | Memorias del Instituto de Investigaciones en Ciencias de la Salud
Jesús Villarrubia, Gloria Muñoz, Crina Ciubotariu, María Domínguez-Ruiz, Miguel Piris‐Villaespesa, María Unceta, Leticia Ceberio, Heather J. Church, Mohsen Norouzi, Mariken Ross, Iván Pérez‐de Pedro, Karolina M. Stępień, Francisco Castillo,
Tópico(s): Sphingolipid Metabolism and Signaling
2022 - Elsevier BV | Molecular Genetics and Metabolism
Lore Merdrignac, Charlotte Lanièce Delaunay, Nuno Verdasca, Lorena Vega‐Piris, Joan O’Donnell, Noémie Sève, Camino Trobajo‐Sanmartín, Silke Buda, Mariëtte Hooiveld, Ana Paula Rodrigues, Gergő Túri, Neus Latorre‐Margalef, Ivan Mlinarić, Mihaela Lazăr, Marine Maurel, Daniel Castrillejo, Charlene Bennett, Marie‐Anne Rameix‐Welti, Iván Martínez‐Baz, Ralf Dürrwald, Adam Meijer, Aryse Martins Melo, Beatrix Oroszi, Tove Samuelsson Hagey, Sanja Filipović, Frederika Dijkstra, Verónica Gómez, Sabrina Bacci, Marlena Kaczmarek, Esther Kissling,
ABSTRACT We estimated XBB.1.5 vaccine effectiveness (VE) against symptomatic SARS‐CoV‐2 infection among adults aged ≥ 65 years during the 2023/2024 JN.1 lineage‐predominant period in a European multi‐country test‐negative case–control study at primary care level. We estimated VE adjusted by study site, age, sex, chronic conditions and onset date. We included 220 cases and 1733 controls. The VE was 48% (95% CI: 12–71), 23% (95% CI: −11–48) and 5% (95% CI: −92–56) among those with symptom onset 1–5, 6–11, ...
Tópico(s): Viral gastroenteritis research and epidemiology
2024 - Wiley | Influenza and Other Respiratory Viruses
Santiago Jesús Camacho Freire, P. Gomez Fernandez, Julio Garcia, Javier León Jiménez, Morales Eugenia Gracia Hiraldo, Iván Sánchez Fernández, E. Massó, Antonio Enrique Gómez Menchero, J Garrido, Rosa Cardenal Piris, José Francisco Díaz Fernández,
Tópico(s): Coronary Interventions and Diagnostics
2017 - Oxford University Press | European Heart Journal
Maher Albitar, Zijun Y. Xu‐Monette, Babak Shahbaba, Ivan De Dios, Yingjun Wang, Deng Manman, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Karen Dybkær, Wayne Tam, Eric D. Hsi, Maurilio Ponzoni, Andrés JM Ferreri, Michael Møller, Miguel Á. Piris, Joannes H.J.M. Van Krieken, Youli Zu, Wanlong Ma, Hagop M. Kantarjian, Yong Li, Ken H. Young,
Introduction: Targeted RNA sequencing using Next Generation Sequencing (NGS) has significant advantages over transcriptome sequencing. In addition to information on mutations, fusion and alternative splicing, RNA quantification using targeted RNA sequencing is sensitive, reproducible and provides better dynamic range. We used targeted RNA sequencing for RNA profiling of diffuse large B-cell lymphoma (DLBCL) and explored its utility in the sub-classification of DLBC to ABC and GCB. Method: RNA extracted ...
Tópico(s): Lymphoma Diagnosis and Treatment
2019 - Elsevier BV | Blood
Maher Albitar, Zijun Y. Xu‐Monette, Wanlong Ma, Yingjun Wang, Deng Manman, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Karen Dybkær, Ivan De Dios, Wayne Tam, Eric D. Hsi, Maurilio Ponzoni, Andrés JM Ferreri, Michael Møller, Miguel Á. Piris, Joannes H.J.M. Van Krieken, Youli Zu, Hagop M. Kantarjian, Yong Li, Ken H. Young,
Tópico(s): T-cell and Retrovirus Studies
2019 - Elsevier BV | Blood
Raúl Córdoba, María Rodríguez‐Pinilla, Narvaez Javier, Fina Climent, Joaquín Sánchez, Carlos Perez Seoane, Javier López Jiménez, Mónica García Cosio, Dolores Caballero, Óscar Javier Blanco Núñez, Cecilia Carpio, Josep Castellví, Antonio Martı́nez, Iván Dlouhy, Ángeles Bendaña, Carlos Aliste, Ana Julia Hoyos González, María Soledad Fernández, Sonia González de Villambrosía, Miguel Á. Piris, José Codina, Émpar Mayordomo, Belén Navarro, Carmen Bellas, Guillermo Rodríguez‐Domínguez, Juan José Borrero Martín, Ana Ruiz‐Zorrilla, Carmen Montoto,
Abstract Purpose The objective of this study was to investigate clinicopathologic features and prognostic factors of patients diagnosed with PTCL in 13 sites across Spain. Patients and Methods A multicenter, retrospective study was carried out between September 2015-November 2017.Medical charts of patients diagnosed with PTCLs between January 2008 and December 2013 that have signed the approved informed consent form were reviewed. PTCLs were then classified according to the 2016 revision of the ...
Tópico(s): Cutaneous lymphoproliferative disorders research
2018 - Elsevier BV | Blood
... Pilarsky, C.Pili, R.Pillai, M.Pinheiro, C.Piris, M.A.Pitha-Rowe, P.Pitson, S.Pittoni, ...
Tópico(s): Epigenetics and DNA Methylation
2011 - American Association for Cancer Research | Cancer Research