Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Shigeki Takada, Hang Zhong, Samuel Suntharalingham, Sandra Vetiska, Daymé Rodrigues Gonzalez, Ruilin Wu, Hubert Rehrauer, Anuroopa Dinesh, Kai Yu, Edward L.Y. Chen, Jeroen Bisschop, Fiona Farnhammer, Ann Mansur, Joanna Kalucka, Itay Tirosh, Luca Regli, Karl Schaller, Karl Frei, Troy Ketela, Mark Bernstein, Paul Kongkham, Peter Carmeliet, Taufik A. Valiante, Peter B. Dirks, Mario L. Suvà, Gelareh Zadeh, Viviane Tabar, Ralph Schlapbach, Hartland W. Jackson, Katrien De Bock, Jason E. Fish, Philippe P. Monnier, Gary D. Bader, Ivan Radovanovic,
Abstract A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood 1 . Here we performed single-cell RNA sequencing analysis of 606,380 freshly isolated endothelial cells, perivascular cells and other tissue-derived cells from 117 samples, from 68 human fetuses and adult patients to construct a molecular atlas ...
Tópico(s): Barrier Structure and Function Studies
2024 - Nature Portfolio | Nature
Stéphanie Lenck, Patrick Nicholson, Rachel Tymianski, Christopher Alan Hilditch, Aurélien Nouet, Krunal Patel, Timo Krings, Michael Tymianski, Ivan Radovanovic, Vítor Mendes Pereira,
... Timo Krings, MD, PhD, Michael Tymianski, MD, PhD, Ivan Radovanovic, MD, PhD and Vitor Mendes Pereira, MD, MSc ... P., M.T., I.R., V.M.P.). , Ivan RadovanovicIvan Radovanovic Krembil Neuroscience Center (M.T., I.R.), University ...
Tópico(s): Meningioma and schwannoma management
2019 - Lippincott Williams & Wilkins | Stroke
Johnny Wong, Rachel Tymianski, Ivan Radovanovic, Michael Tymianski,
... Aneurysms Johnny Ho Yin Wong, PhD, Rachel Tymianski, Ivan Radovanovic, PhD and Michael Tymianski, MD, PhD Johnny Ho ... J.H.Y.W., I.R., M.T.). , Ivan RadovanovicIvan Radovanovic From the Division of Neurosurgery, Toronto Western Hospital, ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2015 - Lippincott Williams & Wilkins | Stroke
Ivan Vajs, Dejan Drajić, Nenad Gligorić, Ilija Radovanović, Ivan Popović,
Existing government air quality monitoring networks consist of static measurement stations, which are highly reliable and accurately measure a wide range of air pollutants, but they are very large, expensive and require significant amounts of maintenance. As a promising solution, low-cost sensors are being introduced as complementary, air quality monitoring stations. These sensors are, however, not reliable due to the lower accuracy, short life cycle and corresponding calibration issues. Recent ...
Tópico(s): Vehicle emissions and performance
2021 - Multidisciplinary Digital Publishing Institute | Sensors
Nataša Djordjević, Dragana Dragaš Milovanović, Маrija Radovanovic, Ivan Radosavljević, Slobodan Obradović, Mihajlo Jakovljević, Dragan Milovanović, Jasmina Milovanović, Slobodan Јаnkovic,
Tópico(s): Epilepsy research and treatment
2016 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Michalina Janiszewska, Mario L. Suvà, Nicolò Riggi, Riekelt H. Houtkooper, Johan Auwerx, Virginie Clément‐Schatlo, Ivan Radovanovic, Esther Rheinbay, Paolo Provero, Ivan Stamenkovic,
Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and maintenance, the energy requirements of these cells and the mechanisms that regulate their energy production are unknown. Here, we show that the oncofetal insulin-like growth factor 2 ...
Tópico(s): Cancer Cells and Metastasis
2012 - Cold Spring Harbor Laboratory Press | Genes & Development
Mario-Luca Suvà, Nicolò Riggi, Michalina Janiszewska, Ivan Radovanovic, Paolo Provero, Jean‐Christophe Stehle, Karine Baumer, Marie‐Aude Le Bitoux, Denis Marino, Luisa Cironi, Víctor E. Márquez, Virginie Clément, Ivan Stamenkovic,
Abstract Overexpression of the polycomb group protein enhancer of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM). Based on its ability to modulate transcription of key genes implicated in cell cycle control, DNA repair, and cell differentiation, EZH2 is believed to play a crucial role in tissue-specific stem cell maintenance and tumor development. Here, we show that targeted pharmacologic disruption of EZH2 by the ...
Tópico(s): Pluripotent Stem Cells Research
2009 - American Association for Cancer Research | Cancer Research
Ivan Popović, Ilija Radovanović, Ivan Vajs, Dejan Drajić, Nenad Gligorić,
Because the number of air quality measurement stations governed by a public authority is limited, many methodologies have been developed in order to integrate low-cost sensors and to improve the spatial density of air quality measurements. However, at the large-scale level, the integration of a huge number of sensors brings many challenges. The volume, velocity and processing requirements regarding the management of the sensor life cycle and the operation of system services overcome the capabilities ...
Tópico(s): IoT and Edge/Fog Computing
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Eleonora Desnica, Aleksandar Ašonja, Ljiljana Radovanović, Ivan Palinkaš, Imre Kiss,
Knowledge of issues related to the selection and dimensioning of roller bearings is extremely important in the work of engineers and designers, and from the point of view of the availability of available literature in this area, in general, is not at the level it should be. The main goal of this paper is to present the current procedures for the selection of roller bearings, to point out the most important factors to consider when choosing standard types of roller bearings, based on which their ...
Tópico(s): Mechanical and Thermal Properties Analysis
2022 - Springer International Publishing | Lecture notes in networks and systems
Aleksandra Djoković, Lj. Stojanovich, Nataša Stanisavljević, V. Bisenić, S. Radovanović, Ivan Soldatović, Dragan Šimić,
Tópico(s): Protein Tyrosine Phosphatases
2013 - Springer Science+Business Media | Rheumatology International
Thomas Wälchli, Jeroen Bisschop, Peter Carmeliet, Gelareh Zadeh, Philippe P. Monnier, Katrien De Bock, Ivan Radovanovic,
Tópico(s): Vascular Malformations Diagnosis and Treatment
2023 - Nature Portfolio | Nature reviews. Neuroscience
Nicole M Cancelliere, Jeremy Lynch, Patrick Nicholson, Tomas Dobrocky, Saravana Kumar Swaminathan, Eef J. Hendriks, Timo Krings, Ivan Radovanovic, Kaitlyn E Drake, Raymond Turner, John‐Michael Sungur, Vítor Mendes Pereira,
The use of robotics in medicine may enable increased technical accuracy, reduced procedural time and radiation exposure, and remote completion of procedures. We have previously described the first-in-human, robotic-assisted cerebral aneurysm treatment using the CorPath GRX Robotic System. In this report we discuss our early experiences and outcomes using this robotic device for endovascular treatment of intracranial aneurysms using stent-assisted coil embolization and flow diversion.The patient ...
Tópico(s): Meningioma and schwannoma management
2021 - BMJ | Journal of NeuroInterventional Surgery
Kartik Bhatia, Hubert Lee, Hans Kortman, Jesse M. Klostranec, Will Guest, Thomas Wälchli, Ivan Radovanovic, Timo Krings, Vítor Mendes Pereira,
SUMMARY: In this second of 3 review articles on the endovascular management of intracranial dural AVFs, we discuss transarterial treatment approaches. The treatment goal is to occlude the fistulous point, including the most distal portion of the arterial supply together with the most proximal portion of the draining vein (ie, the "foot" of the vein), which can be accomplished with liquid embolic agents via transarterial access. Anatomic factors to consider when assessing the safety and efficacy of a transarterial ...
Tópico(s): Trigeminal Neuralgia and Treatments
2021 - American Society of Neuroradiology | American Journal of Neuroradiology
Marie E. Faughnan, Johannes J. Mager, Steven W. Hetts, Valerie A. Palda, Félix Ratjen,
... Plahn , Mary E.M. Porteous , Marco C. Post , Ivan Radovanovic , Paul J. Rochon , Josanna Rodriguez-Lopez , Carlo Sabba , ...
Tópico(s): Dysphagia Assessment and Management
2021 - American College of Physicians | Annals of Internal Medicine
Vítor Mendes Pereira, Patrick Nicholson, Nicole M Cancelliere, Xiao Yu Eileen Liu, Ronit Agid, Ivan Radovanovic, Timo Krings,
OBJECTIVE Geographic factors prevent equitable access to urgent advanced neuroendovascular treatments. Robotic technologies may enable remote endovascular procedures in the future. The authors performed a translational, benchtop-to-clinical study to evaluate the in vitro and clinical feasibility of the CorPath GRX Robotic System for robot-assisted endovascular neurointerventional procedures. METHODS A series of bench studies was conducted using patient-specific 3D-printed models to test the system’ ...
Tópico(s): Acute Ischemic Stroke Management
2021 - American Association of Neurological Surgeons | Journal of neurosurgery
Christopher Alan Hilditch, Waleed Brinjikji, Anderson Chun On Tsang, Patrick Nicholson, Alex Kostynskyy, Michael Tymianski, Timo Krings, Ivan Radovanovic, Vitor PEREIRA,
BACKGROUND: We calculated the PHASES and ELAPSS scores for a large cohort of ruptured intracranial aneurysms (RIA) in order to determine whether these RIA would have been pre-emptively treated or closely followed-up should they have been detected prior to rupture.METHODS: We retrospectively reviewed a consecutive series of RIA over a 20-year period. The primary outcome of this study was the PHASES score of each ruptured aneurysm included. Secondary outcomes were ELAPSS score and other risk factors ...
Tópico(s): Meningioma and schwannoma management
2021 - Edizioni Minerva Medica | Journal of Neurosurgical Sciences
Laura T. van der Kamp, Gabriël J.E. Rinkel, Dagmar Verbaan, René van den Berg, W. Peter Vandertop, Yuichi Murayama, Toshihiro Ishibashi, Antti Lindgren, Timo Koivisto, Mario Teo, Jerome St George, Ronit Agid, Ivan Radovanovic, Junta Moroi, Keiji Igase, Ido R. van den Wijngaard, Melissa Rahi, Jaakko Rinne, Johanna Kuhmonen, Hieronymus D. Boogaarts, George K. C. Wong, Jill Abrigo, Akio Morita, Yoshiaki Shiokawa, K. Hackenberg, Nima Etminan, Irene C. van der Schaaf, Nicolaas P. A. Zuithoff, Mervyn D.I. Vergouwen,
Unruptured intracranial aneurysms not undergoing preventive endovascular or neurosurgical treatment are often monitored radiologically to detect aneurysm growth, which is associated with an increase in risk of rupture. However, the absolute risk of aneurysm rupture after detection of growth remains unclear. To determine the absolute risk of rupture of an aneurysm after detection of growth during follow-up and to develop a prediction model for rupture. Individual patient data were obtained from 15 ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2021 - American Medical Association | JAMA Neurology
Kartik Bhatia, William Guest, Hubert Lee, Jesse M. Klostranec, Hans Kortman, Emanuele Orrù, Ayman Qureshi, Alexander Kostynskyy, Ronit Agid, Richard Farb, Ivan Radovanovic, Patrick Nicholson, Timo Krings, Vítor Mendes Pereira,
Tópico(s): Aortic aneurysm repair treatments
2020 - Springer Science+Business Media | Clinical Neuroradiology
Emanuele Orrù, Henry E. Rice, Laetitia de Villiers, Jesse M. Klostranec, Ajay K. Wakhloo, Alexander L. Coon, Ivan Radovanovic, Hans Kortman, Kartik Bhatia, Timo Krings, Vítor Mendes Pereira,
Objective To describe the results in patients treated with the Surpass Evolve (SE) device, the new generation of Surpass flow diverters. Methods Twenty-five consecutive patients (20 women, average age 58 years), with anterior or posterior circulation aneurysms treated with SEs in two early-user centers, were included. Device properties and related technical properties, imaging and clinical follow-up data, and intraprocedural, early (<30 days) and delayed (>30 days) neurological complications, further ...
Tópico(s): Aortic aneurysm repair treatments
2020 - BMJ | Journal of NeuroInterventional Surgery
Nicole M Cancelliere, Patrick Nicholson, Ivan Radovanovic, Karla Mirella Silva Lobato Mendes, Emanuele Orrù, Timo Krings, Vítor Mendes Pereira,
Background Flow diverting stent (FDS) devices have revolutionized the treatment of large and complex brain aneurysms, but there is still room for improvement, particularly on the flow diversion properties and technical challenges associated with stent deployment. In this study we compared flow diversion properties between the new generation Surpass Evolve (Stryker) and the Pipeline Flex (Medtronic) devices by quantitatively evaluating intra-aneurysmal flow modification. Methods An in vitro experimental ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2020 - BMJ | Journal of NeuroInterventional Surgery
Vítor Mendes Pereira, Nicole M Cancelliere, Mehdi Najafi, Daniel E. MacDonald, Thangam Natarajan, Ivan Radovanovic, Timo Krings, John Rutka, Patrick Nicholson, David A. Steinman,
Background Pulsatile tinnitus (PT) is a debilitating condition that can be caused by a vascular abnormality, such as an arterial or venous lesion. Although treatment of PT-related venous lesions has been shown to successfully cure patients of the associated ‘tormenting’ rhythmical sound, much controversy still exists regarding their role in the etiology of PT. Methods A patient presented with a history of worsening, unilateral PT. A partial venous sinus obstruction related to the large arachnoid granulation ...
Tópico(s): Vestibular and auditory disorders
2020 - BMJ | Journal of NeuroInterventional Surgery
Christoph J. Griessenauer, Alejandro Enríquez-Marulanda, Sissi Xiang, Tao Hong, Hongqi Zhang, Philipp Taussky, Ramesh Grandhi, Muhammad Waqas, Vincent M. Tutino, Adnan H. Siddiqui, Elad I. Levy, Christopher S. Ogilvy, Ajith J. Thomas, Christian Ulfert, Markus Möhlenbruch, Leonardo Renieri, Nicola Limbucci, Carmen Parra-Fariñas, Jan‐Karl Burkhardt, Peter Kan, Lorenzo Rinaldo, Giuseppe Lanzino, Waleed Brinjikji, Julian Spears, Erasmia Broussalis, Monika Killer‐Oberpfalzer, Civan Işlak, Naci Koçer, Michael Sonnberger, Tobias Engelhorn, Mandeep S. Ghuman, Victor X. D. Yang, Arsalaan Salehani, Mark R. Harrigan, Ivan Radovanovic, Vítor Mendes Pereira, Timo Krings, Charles Matouk, Karen Chen, Mohammad Ali Aziz‐Sultan, Mohammad Ghorbani, Clemens M. Schirmer, Oded Goren, Shamsher Dalal, Matthew J. Koch, Christopher J. Stapleton, Aman B. Patel, Thomas Finkenzeller, Markus Holtmannspötter, Jan Hendrik Buhk, Paul M. Foreman, Marshall C. Cress, Robert Hirschl, W. Reith, Andreas Simgen, Hendrik Janssen, Thomas R. Marotta, Adam A. Dmytriw,
Flow diversion is a common endovascular treatment for cerebral aneurysms, but studies comparing different types of flow diverters are scarce.To perform a propensity score matched cohort study comparing the Pipeline Embolization Device (PED) and Flow Redirection Intraluminal Device (FRED) for posterior circulation aneurysms.Consecutive aneurysms of the posterior circulation treated at 25 neurovascular centers with either PED or FRED were collected. Propensity score matching was used to control for ...
Tópico(s): Meningioma and schwannoma management
2020 - BMJ | Journal of NeuroInterventional Surgery
Vítor Mendes Pereira, Nicole M Cancelliere, Patrick Nicholson, Ivan Radovanovic, Kaitlyn E Drake, John‐Michael Sungur, Timo Krings, Aquilla S Turk,
Robotic-assisted technology has been used as a tool to enhance open and minimally invasive surgeries as well as percutaneous coronary and peripheral vascular interventions. It offers many potential benefits, including increased procedural and technical accuracy as well as reduced radiation dose during fluoroscopic procedures. It also offers the potential for truly “remote” procedures. Despite these benefits, robotic technology has not yet been used in the neuroendovascular field, aside from diagnostic ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2020 - BMJ | Journal of NeuroInterventional Surgery
Kartik Bhatia, Hans Kortman, Thomas Wälchli, Ivan Radovanovic, Vítor Mendes Pereira, Timo Krings,
SUMMARY: The artery of Davidoff and Schechter is a dural branch of the posterior cerebral artery that can supply the meninges close to the falcotentorial junction. It is usually not identified on angiography except when enlarged in the setting of a dural AVF or meningioma. The impact on treatment of the artery of Davidoff and Schechter supply to a fistula is not well-described in the literature. Our retrospective analysis of patients with dural AVFs treated at the Toronto Western Hospital between 2006 and ...
Tópico(s): Neurosurgical Procedures and Complications
2020 - American Society of Neuroradiology | American Journal of Neuroradiology
Marie E. Faughnan, Johannes J. Mager, Steven W. Hetts, Valerie A. Palda, Kelly Lang‐Robertson, Elisabetta Buscarini, Érik Deslandres, Raj S. Kasthuri, Andrea Lausman, David M. Poetker, Félix Ratjen, Mark S. Chesnutt, Marianne S. Clancy, Kevin J. Whitehead, Hanny Al‐Samkari, Murali M. Chakinala, Miles Conrad, Daniel H. Cortes, Claudia Crocione, Jama M. Darling, Els de Gussem, Carol Derksen, Sophie Dupuis‐Girod, Patrick Foy, Urban W. Geisthoff, James R. Gossage, Adrienne M. Hammill, Ketil Heimdal, Katharine Henderson, Vivek N. Iyer, Anette Drøhse Kjeldsen, Masaki Komiyama, Kevin Korenblat, Jamie McDonald, Jack McMahon, Justin P. McWilliams, Mary E. Meek, Meir Mei‐Zahav, Scott E. Olitsky, Sara Palmer, Rose Pantalone, Jay F. Piccirillo, Beth Plahn, Mary Porteous, Marco C. Post, Ivan Radovanovic, Paul J. Rochon, Josanna Rodriguez‐Lopez, Carlo Sabbà, Marcelo Serra, Claire L. Shovlin, Dennis L. Sprecher, Andrew J. White, Ingrid Winship, Roberto Zarrabeitia,
Description: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease with an estimated prevalence of 1 in 5000 that is characterized by the presence of vascular malformations (VMs). These result in chronic bleeding, acute hemorrhage, and complications from shunting through VMs. The goal of the Second International HHT Guidelines process was to develop evidence-based consensus guidelines for the management and prevention of HHT-related symptoms and complications. Methods: The guidelines ...
Tópico(s): Sharing Economy and Platforms
2020 - American College of Physicians | Annals of Internal Medicine
Jason E. Fish, Carlos Perfecto Flores Suarez, Émilie Boudreau, Alexander M. Herman, Manuel Cantu Gutierrez, Dakota Gustafson, Peter V. DiStefano, Meng Cui, Zhiqi Chen, Karen Berman de Ruiz, Taylor S. Schexnayder, Christopher Ward, Ivan Radovanovic, Joshua D. Wythe,
Rationale: We previously identified somatic activating mutations in the KRAS ( Kirsten rat sarcoma viral oncogene homologue ) gene in the endothelium of the majority of human sporadic brain arteriovenous malformations; a disorder characterized by direct connections between arteries and veins. However, whether this genetic abnormality alone is sufficient for lesion formation, as well as how active KRAS signaling contributes to arteriovenous malformations, remains unknown. Objective: To establish the ...
Tópico(s): Retinal Diseases and Treatments
2020 - Lippincott Williams & Wilkins | Circulation Research
Ivan Radovanovic, Amir R. Dehdashti, Mazda K. Turel, João Paulo Almeida, Bruno Loyola Godoy, Francesco Doglietto, Allan Vescan, Gelareh Zadeh, Fred Gentili,
Abstract BACKGROUND The role of expanded endonasal endoscopic surgery for primary and recurrent craniopharyngioma is not yet fully established. OBJECTIVE To report and evaluate our experience with the endoscopic endonasal approach (EEA) for the resection of primary and recurrent craniopharyngiomas. METHODS This is a retrospective cohort analysis of 43 consecutive EEA procedures in 40 patients operated from September 2006 to February 2012 for suprasellar craniopharyngiomas. In 21 patients (48.8%) the ...
Tópico(s): Head and Neck Surgical Oncology
2019 - Lippincott Williams & Wilkins | Operative Neurosurgery
Nardin Samuel, Ivan Radovanovic,
OBJECTIVE Despite the prevalence and impact of intracranial aneurysms (IAs), the molecular basis of their pathogenesis remains largely unknown. Moreover, there is a dearth of clinically validated biomarkers to efficiently screen patients with IAs and prognosticate risk for rupture. The aim of this study was to survey the literature to systematically identify the spectrum of genetic aberrations that have been identified in IA formation and risk of rupture. METHODS A literature search was performed ...
Tópico(s): Connective tissue disorders research
2019 - American Association of Neurological Surgeons | Neurosurgical FOCUS
Stéphanie Lenck, Ivan Radovanovic, Patrick Nicholson, Mojgan Hodaie, Timo Krings, Vitor Mendes-Pereira,
The recent discoveries of the glymphatic and lymphatic systems of the brain have helped advance our understanding of CSF physiology and may allow new insights in the understanding of idiopathic intracranial hypertension (IIH). The clinical and radiologic presentations of IIH appear to be related to congestion of the glymphatic system associated with an overflow of the lymphatic CSF outflow pathway. By revisiting the role of "vascular arachnoid granulations" in the brain, we hypothesize that an initial ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2018 - Lippincott Williams & Wilkins | Neurology
Tao Hong, Yupeng Yan, Jingwei Li, Ivan Radovanovic, Xiangyuan Ma, Yang Shao, Jiaxing Yu, Yongjie Ma, Peng Zhang, Feng Ling, Shuchen Huang, Hongqi Zhang, Yibo Wang,
Brain and spinal arteriovenous malformations are congenital lesions causing intracranial haemorrhage or permanent disability especially in young people. We investigated whether the vast majority or all brain and spinal arteriovenous malformations are associated with detectable tumour-related somatic mutations. In a cohort of 31 patients (21 with brain and 10 with spinal arteriovenous malformations), tissue and paired blood samples were analysed with ultradeep next generation sequencing of a panel ...
Tópico(s): Retinal and Macular Surgery
2018 - Oxford University Press | Brain