Produção Nacional
Revisado por pares
Beatriz J. Souza, Tiago De Oliveira, Thiago Mendonça de Aquino, Maria C. Pedroso de Lima, Ivan da Rocha Pitta, Suely Lins Galdino, Edeltrudes de Oliveira Lima, Teresinha Gonçalves-Silva, Gardênia Carmen Gadelha Militão, Luciana Scotti, Marcus Tullius Scotti, Francisco Jaime Bezerra Mendonça,
Preliminary antifungal and cytotoxic evaluation of synthetic cycloalkyl[ b ]thiophene derivatives with PLS-DA analysis A series of 2-[(arylidene)amino]-cycloalkyl[ b ]thiophene-3-carbonitriles ( 2a-x ) was synthesized by incorporation of substituted aromatic aldehydes in Gewald adducts ( 1a-c ). The title compounds were screened for their antifungal activity against Candida krusei and Criptococcus neoformans and for their antiproliferative activity against a panel of 3 human cancer cell lines (HT29, NCI H-292 ...
Tópico(s): Synthesis of Organic Compounds
2012 - De Gruyter Open | Acta Pharmaceutica
Produção Nacional
Revisado por pares
Laurindo Ferreira da Rocha, Moacyr Jesus Barreto de Melo Rêgo, Mariana Brayner Cavalcanti, Michelly Cristiny Pereira, Marina Galdino da Rocha Pitta, Priscilla Stela Santana de Oliveira, Sayonara Maria Calado Gonçalves, Ângela Luzia Branco Pinto Duarte, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Maíra Galdino da Rocha Pitta,
Rheumatoid arthritis (RA) is an autoimmune disease frequently characterized by chronic synovitis of multiple joints. The pathogenesis of RA is complex and involves many proinflammatory cytokines as Th17 related ones. PPAR γ is a nuclear receptor activator that represses proinflammatory gene expression. Thus, this work aimed to synthetize a new thiazolidinedione (TZD) analogue based on a well-known anti-inflammatory and PPAR γ agonist activity of this ring and evaluate its anti-inflammatory activity. ...
Tópico(s): Inflammatory mediators and NSAID effects
2013 - Hindawi Publishing Corporation | BioMed Research International
Produção Nacional
Revisado por pares
Eric Matheus Rocha Lima, Ivan Wallan Tertuliano, Carlos Norberto Fischer,
Football is the most popular sport in the world and involves the availability of information of footballers and teams to investigate success in this sport. In account of these aspects, the current study aims to analyze the influence of ball possession time, passes and shots on target in winning Premier League football matches. The methodology adopted consists of a quantitative, descriptive and documentary research, in which the sample is represented by all the 380 Premier League (PL) matches of the ...
Tópico(s): Sports and Physical Education Research
2021 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
Produção Nacional
Revisado por pares
Eric Matheus Rocha Lima, Ivan Wallan Tertuliano, Carlos Norberto Fischer,
The technology growth allowing analysis acts to gain more efficiency in football has increased, with performance analysis researches being conducted, since the knowledge of performance indicators that can determine success in football and the need for more predictive analysis to better comprehend them are essential. So, in account of these aspects this research aimed to investigate the influence of crosses, shots, corner kicks and defensive movements in winning Premier League (PL) football matches. ...
Tópico(s): Sports and Physical Education Research
2021 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
Produção Nacional
Revisado por pares
Amanda Karolina Soares e Silva, Dilênia de Oliveira Cipriano Torres, Fabiana Oliveira dos Santos Gomes, Bruna dos Santos Silva, Edlene Lima Ribeiro, A. C. Oliveira, Laise Aline Martins dos Santos, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Christina Alves Peixoto,
Non-alcoholic fatty liver disease (NAFLD) defines a wide spectrum of liver diseases that extends from simple steatosis to non-alcoholic steatohepatitis. Although the pathogenesis of NAFLD remains undefined, it is recognized that insulin resistance is present in almost all patients who develop this disease. Thiazolidinediones (TZDs) act as an insulin sensitizer and have been used in the treatment of patients with type 2 diabetes and other insulin-resistant conditions, including NAFLD. Hence, therapy ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2015 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Luciana Scotti, Marcus Tullius Scotti, Edeltrudes de Oliveira Lima, Marcelo Sobral da Silva, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Ricardo Olímpio de Moura, Jaismary Gonzaga Batista de Oliveira, Rayssa Marques Duarte da Cruz, Francisco Jaime Bezerra Mendonça,
Fifty 2-[(arylidene)amino]-4,5-cycloalkyl[b]thiophene-3-carbonitrile derivatives were screened for their in vitro antifungal activities against Candida krusei and Cryptococcus neoformans. Based on experimentally determined minimum inhibitory concentration (MIC) values, we conducted computer-aided drug design studies [molecular modelling, chemometric tools (CPCA, PCA, PLS) and QSAR-3D] that enable the prediction of three-dimensional structural characteristics that influence the antifungal activities ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - Multidisciplinary Digital Publishing Institute | Molecules
Francimary L. Guedes, Boaz G. Oliveira, Marcelo Zaldini Hernandes, Carlos A. de Simone, Francisco Veiga, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Suely Lins Galdino, Pedró José Rolim Neto,
Solid dispersions have been used as a strategy to improve the solubility, dissolution rate, and bioavailability of poor water-soluble drugs. The increase of the dissolution rate presented by (5Z)-3-(4-chloro-benzyl)-5-(4-nitro-benzylidene)-imidazolidine-2,4-dione (LPSF/FZ4) from the solid dispersions is related to the existence of intermolecular interactions of hydrogen bond type (>N-H···O<) between the amide group (>N-H) of the LPSF/FZ4 and the ether group (-O-) of the polyethyleneglycol polymer, or the ...
Tópico(s): Analytical Methods in Pharmaceuticals
2011 - Springer Science+Business Media | AAPS PharmSciTech
Produção Nacional
Revisado por pares
Luciane Aparecida Faine, Martina Rudnicki, Fernanda Andrade de César, Beatriz de las Heras, Lisardo Boscá, Érika Silva Souza, Marcelo Zaldini Hernandes, Suely Lins Galdino, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Dulcinéia Saes Parra Abdalla,
Thiazolidinediones (TZDs) are a class of drugs used for treatment of type 2 diabetes. However, the therapy with currently available TDZs (e.g. rosiglitazone) is associated with important side effects, such as edema and weight gain, suggesting that the investigation of alternative TZDs with better pharmacological properties is warranted. In this study, we investigated both anti-inflammatory and antioxidant properties of a new chemically modified TZD, the arylidene-thiazolidinedione 5-(4-methanesulfonyl- ...
Tópico(s): NF-κB Signaling Pathways
2011 - Bentham Science Publishers | Current Medicinal Chemistry
Produção Nacional
Revisado por pares
Juliana Kelle de Andrade Lemoine Neves, Sandra Paula Sarinho Botelho, Cristiane Moutinho Lagos de Melo, Valéria Rêgo Alves Pereira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Mônica Camelo Pessôa de Azevedo Albuquerque, Suely Lins Galdino,
Tópico(s): Macrophage Migration Inhibitory Factor
2010 - Springer Science+Business Media | Parasitology Research
Produção Nacional
Revisado por pares
Boaz G. Oliveira, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Suely Lins Galdino, Marcelo Zaldini Hernandes,
Tópico(s): Crystallography and molecular interactions
2009 - Springer Science+Business Media | Journal of Molecular Modeling
Produção Nacional
Revisado por pares
Francisco W.A. Barros, Daniel P. Bezerra, Paulo Michel Pinheiro Ferreira, Bruno C. Cavalcanti, Teresinha Gonçalves da Silva, Marina Galdino da Rocha Pitta, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Letícia V. Costa‐Lotufo, Manoel Odorico de Moraes, Rommel Mário Rodríguez Burbano, Temenouga Nikolova Guecheva, João Antônio Pêgas Henriques, Cláudia Pessoa,
Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione - AC-4; (5ZE)-5-acridin-9-ylmethylene-3-(4-bromo-benzyl)-thiazolidine-2,4-dione - AC-7; (5Z)-5-(acridin-9-ylmethylene)-3-(4-chloro-benzyl)-1,3-thiazolidine-2,4-dione - AC-10; and (5ZE)-5-(acridin-9-ylmethylene)-3-(4-fluoro- ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2013 - Elsevier BV | Toxicology and Applied Pharmacology
Produção Nacional
Revisado por pares
Giovanna C. R. M. Schver, Dajun Sun, Salvana Priscylla Manso Costa, Keyla E.R. Silva, Jamerson Ferreira de Oliveira, Larissa Araújo Rolim, Mônica Camelo Pessôa de Azevedo Albuquerque, André de Lima Aires, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Ping I. Lee, Pedró José Rolim Neto,
Drug candidate LPSF/FZ4 with promising schistosomicidal properties in vitro was previously synthesized. However, LPSF/FZ4 has limited aqueous solubility (<1 μg/mL), leading to ineffective dissolution and, therefore, no meaningful in vivo comparative studies could be pursued. This study was aimed to develop a proper amorphous solid dispersion (SD) to enhance the solubility and dissolution rate of LPSF/FZ4 such that its biological activity could be investigated. To better understand its physiological ...
Tópico(s): Drug Transport and Resistance Mechanisms
2018 - Elsevier BV | European Journal of Pharmaceutical Sciences
Produção Nacional
Revisado por pares
Roberto F. S. Andrade, Ivan Carmo Rocha-Neto, Leonardo Bacelar Lima Santos, Charles Novaes de Santana, Marcelo V.C. Diniz, Thierry Petit Lobão, Aristóteles Goés‐Neto, Suani T. R. Pinho, Charbel Niño El-Hani,
This paper proposes a new method to identify communities in generally weighted complex networks and apply it to phylogenetic analysis. In this case, weights correspond to the similarity indexes among protein sequences, which can be used for network construction so that the network structure can be analyzed to recover phylogenetically useful information from its properties. The analyses discussed here are mainly based on the modular character of protein similarity networks, explored through the Newman- ...
Tópico(s): Evolution and Paleontology Studies
2011 - Public Library of Science | PLoS Computational Biology
Produção Nacional
Revisado por pares
Rafaela Silva Guimarães Gonçalves, Michelly Cristiny Pereira, Andréa Tavares Dantas, Anderson Rodrigues de Almeida, Moacyr Jesus Barreto de Melo Rêgo, Emerson Andrade Lima, Ivan da Rocha Pitta, Ângela Luzia Branco Pinto Duarte, Maíra Galdino da Rocha Pitta,
Abstract Although several cytokines and chemokines have been investigated as possible mediators of fibrosis in systemic sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. We studied the profile of antifibrotic and profibrotic transcripts involved in skin of SSc patients. The mRNA expression was detected by fluorescence‐based quantitative real‐time PCR (qPCR) in skin's biopsies ...
Tópico(s): Skin Diseases and Diabetes
2019 - Wiley | Experimental Dermatology
Produção Nacional
Revisado por pares
Thiago Moreira, Artur Felipe Santos Barbosa, Phercyles Veiga-Santos, Cristina Henriques, Andrea Henriques‐Pons, Suely Lins Galdino, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Wanderley de Souza, Técia Maria Ulisses de Carvalho,
Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic illness in Latin America. Efforts have been made by several groups to develop new effective and safe anti-T. cruzi drugs. In the present work, we show that thiazolidine LPSF SF29 inhibited growth of the epimastigote and amastigote forms and caused lysis in the trypomastigote form of T. cruzi, leading to death of the protozoan. Mitochondrial dysfunction was also observed. The thiazolidine induced ultrastructural alterations ...
Tópico(s): Lysosomal Storage Disorders Research
2012 - Elsevier BV | International Journal of Antimicrobial Agents
Produção Nacional
Revisado por pares
Moacyr Jesus Barreto de Melo Rêgo, Wanessa Layssa Batista de Sena, Ricardo Olímpio de Moura, Íris Trindade Tenório Jacob, Thiago Ubiratan Lins e Lins, Michelly Cristiny Pereira, Maria do Carmo Alves de Lima, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Maíra Galdino da Rocha Pitta,
Aim and Objective: Cancer has become one of the leading causes of morbidity and mortality worldwide. Limitations associated with existing agents increase the need to develop more effective anticancer drugs to improve the therapeutic arsenal available. The aim of this study was to synthesize and evaluate the antiproliferative effects of three new thiazacridine derivatives. Material and Methods: Using a three steps synthesis reaction, three novel thiazacridine derivatives were obtained and characterized: ( ...
Tópico(s): Biochemical and Molecular Research
2017 - Bentham Science Publishers | Combinatorial Chemistry & High Throughput Screening
Produção Nacional
Revisado por pares
Flaviana Alves dos Santos, Michelly Cristiny Pereira, Tiago Bento de Oliveira, Francisco Jaime Bezerra Mendonça, Maria do Carmo Alves de Lima, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Maíra Galdino da Rocha Pitta,
Substitutions in thiophene structure give rise to new derivatives with different biological and pharmacological activities. The present study investigated the cytotoxicity activity of some thiophene derivatives in breast cancer cells maintained in two-dimensional (2D) or in three-dimensional (3D) culture and evaluated the anticancer mechanism of these compounds. Cytotoxicity assays were performed against untransformed cells and against breast cancer cell MCF-7. Apoptosis analysis and in-vitro migration ...
Tópico(s): Synthesis and biological activity
2017 - Lippincott Williams & Wilkins | Anti-Cancer Drugs
Produção Nacional
Revisado por pares
Michella Soares Coêlho, Caroline Lourenço de Lima, Carine Royer, Janaina Barbosa da Silva, Fernanda Cerqueira Barroso Oliveira, Camila G. Christ, Sidney Alcântara Pereira, Sônia Nair Báo, Maria do Carmo Alves de Lima, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Francisco de Assis Rocha Neves, Angélica Amorim Amato,
Background Beige adipocytes comprise a unique thermogenic cell type in the white adipose tissue (WAT) of rodents and humans, and play a critical role in energy homeostasis. In this scenario, recruitment of beige cells has been an important focus of interest for the development of novel therapeutic strategies to treat obesity. PPARγ activation by full agonists (thiazolidinediones, TZDs) drives the appearance of beige cells, a process so-called browning of WAT. However, this does not translate into ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Moacyr Jesus Barreto de Melo Rêgo, Marina Rocha Galdino-Pitta, Daniel Tarciso Martins Pereira, Juliana Cruz da Silva, Marcelo Montenegro Rabello, Maria do Carmo Alves de Lima, Marcelo Zaldini Hernandes, Ivan da Rocha Pitta, Suely Lins Galdino, Maíra Galdino da Rocha Pitta,
Tópico(s): Synthesis of heterocyclic compounds
2014 - Springer Science+Business Media | Medicinal Chemistry Research
Produção Nacional
Revisado por pares
Marina Galdino da Rocha Pitta, Érika Silva Souza, Francisco W.A. Barros, Manoel Odorico Moraes Filho, Cláudia Pessoa, Marcelo Zaldini Hernandes, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta,
Tópico(s): Bioactive Compounds and Antitumor Agents
2012 - Springer Science+Business Media | Medicinal Chemistry Research
Produção Nacional
Revisado por pares
Maíra Galdino da Rocha Pitta, Andréa CA Silva, Juliana Kelle A.L. Neves, Poliana G Silva, João Inácio Irmão, Elizabeth Malagueño, José Valfrido de Santana, Maria CA Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Mônica C. P. A. Albuquerque,
The emergence of strains of Schistosoma resistant to praziquantel has drawn attention to the search for new schistosomacide drugs. Imidazolidinic derivatives have performed outstandingly against adult S. mansoni worms when evaluated in vitro. The molecular modification of imidazolidine by way of bioisosteric replacement gives rise to variations in its biological response. This study verifies the potential of substituent groups in the derivatives (Z)3-benzyl-5-(2-fluoro-benzylidene)-imidazolidine- ...
Tópico(s): Helminth infection and control
2006 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Francisco W.A. Barros, Teresinha Gonçalves da Silva, Marina Galdino da Rocha Pitta, Daniel P. Bezerra, Letícia V. Costa‐Lotufo, Manoel Odorico de Moraes, Cláudia Pessoa, Maria Aline Barros Fidelis de Moura, Fabiane C. de Abreu, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Marília Oliveira Fonseca Goulart,
Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2012 - Elsevier BV | Bioorganic & Medicinal Chemistry
Produção Nacional
Revisado por pares
Fernanda Andrade de César, Martina Rudnicki, Beatriz de las Heras, Lisardo Boscá, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Dulcinéia Saes Parra Abdalla,
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that improve insulin-mediated glucose uptake and possess beneficial vasculoprotective actions. However, because undesirable side effects are associated with these drugs, novel TZDs are under development. In this study, we evaluated the biological activity of LYSO-7, a new indole-thiazolidine, on PPAR activation, inflammation and atherogenesis using a gene reporter assay, lipopolysaccharide (LPS)-activated RAW ...
Tópico(s): Immune cells in cancer
2015 - Elsevier BV | Vascular Pharmacology
Produção Nacional
Revisado por pares
Benedito Rocha Vital, Paulo Ivan Lima de Andrade, Angélica de Cássia Oliveira Carneiro, Carla Priscilla Távora Cabral, Ana Márcia Macêdo Ladeira Carvalho,
O objetivo deste trabalho foi avaliar o efeito do tratamento térmico em algumas propriedades de painéis de partículas, produzidos com resíduos de embalagens de Pinus sp. Foi utilizado o adesivo à base de ureia-formaldeído, na quantidade de 8%. O experimento foi desenvolvido em um fatorial 4 x 3 x 3, sendo quatro proporções de partículas (25, 50, 75 e 100%), termorretificadas, três temperaturas de tratamento térmico (180, 200 e 220 ºC) e três repetições, totalizando 36 painéis. Foram produzidos mais ...
Tópico(s): Lignin and Wood Chemistry
2014 - Sociedade de Investigações Florestais | Revista Árvore
Produção Nacional
Revisado por pares
Shyrlene Meiry Rocha Araújo, Amanda Soares e Silva, Fabiana Gomes, Edlene Lima Ribeiro, Wilma Helena de Oliveira, A. C. Oliveira, Ingrid Tavares de Lima, Maria do Carmo Alves de Lima, Ivan da Rocha Pitta, Christina Alves Peixoto,
Non-alcoholic fatty liver disease (NAFLD) is considered the most common manifestation of metabolic syndrome. One of its most important features is the accumulation of triglycerides in the hepatocyte cells. Thiazolidinediones (TZDs) act as insulin sensitizers and are used to treat patients with type 2 diabetes and other conditions that are resistant to insulin, such as hepatic steatosis. Controversially, TZDs are also associated with the development of cardiovascular events and liver problems. For ...
Tópico(s): Diet, Metabolism, and Disease
2016 - Elsevier BV | European Journal of Pharmacology
Produção Nacional
Revisado por pares
Salvana Priscylla Manso Costa, Keyla Emanuelle Ramos da Silva, Giovanna Christinne Rocha de Medeiros, Larissa Araújo Rolim, Jamerson Ferreira de Oliveira, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta, Pedró José Rolim Neto,
In this study, differential scanning calorimetry and thermogravimetry were employed to determine the thermal behavior of LPSF/FZ4 isolated and associated with excipients (amide, β-cyclodextrin, cellulose, lactose, stearate of magnesium, aerosil, sodium lauryl sulfate, polysorbate and polyvinylpyrrolidone). Thus, the purity of the prototype calculated was 98%. Isothermal and non-isothermal methods were used to determine the kinetic parameters of decomposition, finding a first-reaction order and activation ...
Tópico(s): Chemical Thermodynamics and Molecular Structure
2013 - Elsevier BV | Thermochimica Acta
Produção Nacional
Revisado por pares
Júlia Furtado Campos, Michelly Cristiny Pereira, Wanessa Layssa Batista de Sena, Caio Martins, Jamerson Ferreira de Oliveira, Cézar Augusto da Cruz Amorim, Moacyr Jesus Barreto de Melo Rêgo, Marina Galdino da Rocha Pitta, Maria do Carmo Alves de Lima, Maíra Galdino da Rocha Pitta, Ivan da Rocha Pitta,
Tópico(s): Eicosanoids and Hypertension Pharmacology
2017 - Elsevier BV | Pharmacological Reports
Produção Nacional
Revisado por pares
Giani Martins Garcia, Líliam Teixeira Oliveira, Ivan da Rocha Pitta, Maria do Carmo Alves de Lima, José Mário Carneiro Vilela, Margareth Spangler Andrade, Dulcinéia Saes Parra Abdalla, Vanessa Carla Furtado Mosqueira,
We report the in vitro release profile and comparative pharmacokinetics and biodistribution of a new peroxisome proliferator-activated receptor-γ agonist and cyclooxygenase inhibitor (Lyso-7) free or associated to poly(d,l-lactic acid) nanocapsules (NC) after intravenous administration in mice. Lyso-7 pertains to the class of insulin-sensitizing agents that shows potential beneficial effects in diabetes therapy. Monodispersed Lyso-7 NC with a mean diameter of 273 nm with high encapsulation efficiency ( ...
Tópico(s): Diabetes Treatment and Management
2015 - Elsevier BV | Journal of Controlled Release
Produção Nacional
Revisado por pares
Elisângela Afonso Moura Mendonça, Mariane Cajubá de Britto Lira Nogueira, Marcelo Montenegro Rabello, Isabella Macário Ferro Cavalcanti, Suely Lins Galdino, Ivan da Rocha Pitta, Maria do Carmo Alves de Lima, Maíra Galdino da Rocha Pitta, Marcelo Zaldini Hernandes, Nereide Stela Santos-Magalhães,
LPSF/AC04 (5Z)-[5-acridin-9-ylmethylene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione] is an acridine-based derivative, part of a series of new anticancer agents synthesized for the purpose of developing more effective and less toxic anticancer drugs. However, the use of LPSF/AC04 is limited due to its low solubility in aqueous solutions. To overcome this problem, we investigated the interaction of LPSF/AC04 with hydroxypropyl-β-cyclodextrin (HP-β-CyD) and hydroxypropyl-γ-cyclodextrin (HP-γ-CyD) in inclusion ...
Tópico(s): Enzyme Catalysis and Immobilization
2012 - Springer Science+Business Media | AAPS PharmSciTech
Produção Nacional
Revisado por pares
Roberto T. Sudo, Rachel Vieiralves do Amaral, Carlos Eduardo da Silva Monteiro, Ivan da Rocha Pitta, Maria do Carmo Alves de Lima, Guilherme Carneiro Montes, Douglas G. Ririe, Ken–ichiro Hayashida, Gisele Zapata‐Sudo,
The mechanisms and antinociceptive effects of a novel α2A adrenoceptor agonist, 3-(2-chloro-6-fluorobenzil)-imidazolinide-2,4-dione (PT-31) were investigated using animal models of acute and chronic pain. The effects of PT-31 on pain responses were examined using hot plate and formalin tests in mice and spinal nerve ligation (SNL)-induced hyperalgesia in rats. The effects of antagonists acting on α adrenoceptor were assessed to investigate the interaction of these pathways upon PT-31 induced antinociception. ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - Elsevier BV | European Journal of Pharmacology