Hugo Groult, Jesús Ruíz‐Cabello, Ana Victoria Lechuga‐Vieco, Jesús Mateo, Marina Benito, Izaskun Bilbao, María Paz Martínez‐Alcázar, Juan Antonio López, Jesús Vázquez, Fernando Herranz,
Abstract We report the synthesis of micellar phosphatidylcholine‐coated superparamagnetic iron oxide nanoparticles as a new long circulation contrast agents for magnetic resonance imaging. Oleic acid‐coated Fe 3 O 4 nanoparticles were first prepared through thermal degradation and then encapsulated into small clusters with a phosphatidylcholine coating to obtain hydrophilic nanomicelles. A thorough characterization confirmed the chemical nature of the coating and the excellent colloidal stability ...
Tópico(s): Iron Metabolism and Disorders
2014 - Wiley | Chemistry - A European Journal
Vinatha Sreeramkumar, José M. Adrover, Iván Ballesteros, María Isabel Cuartero, Jan Rossaint, Izaskun Bilbao, María Nácher, Christophe Pitaval, Irena Radovanovic, Yoshinori Fukui, Rodger P. McEver, Marie-Dominique Filippi, Ignacio Lizasoaín, Jesús Ruíz‐Cabello, Alexander Zarbock, Marı́a A. Moro, Andrés Hidalgo,
Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2014 - American Association for the Advancement of Science | Science
Carla Mazzeo, Cristina Gámez, Ainara Rodríguez Marco, Ana de Zulueta, Verónica Sanz, Izaskun Bilbao, Jesús Ruíz‐Cabello, José Manuel Zubeldia, Victoria del Pozo,
Suppresors of cytokine signaling (SOCS) proteins regulate cytokine responses and control immune balance. Several studies have confirmed that SOCS3 is increased in asthmatic patients, and SOCS3 expression is correlated with disease severity. The objective of this study was to evaluate if delivering of SOCS3 short interfering RNA (siRNA) intranasally in lungs could be a good therapeutic approach in an asthma chronic mouse model. Our results showed that intranasal treatment with SOCS3-siRNA led to an ...
Tópico(s): Chemokine receptors and signaling
2014 - Public Library of Science | PLoS ONE
Fermín Fernández‐Calderón, Óscar M. Lozano, Antonio José Rojas Tejada, Izaskun Bilbao-Acedos, Claudio Vidal Giné, Esperanza Vergara‐Moragues, Francisco González‐Saiz,
Background Raves may be considered recreational settings in which drug use and health risks related to polydrug use are higher than in others. Harm reduction behaviors implemented by ravers are of particular relevance in reducing such risks. This study analyzes harm reduction behaviors and their relationship to raver polysubstance use patterns. Methods Cross-sectional study of 248 ravers recruited at underground raves in Andalusia (Spain). A questionnaire was developed to collect information about ...
Tópico(s): Cannabis and Cannabinoid Research
2013 - SAGE Publishing | Substance Abuse
Elena Prieto, Pablo Lecumberri, Miguel Pagola, Marisol Gómez, Izaskun Bilbao, Margarita Ecay, Iván Peñuelas, Josep M. Martí‐Climent,
Tumor volume delineation over positron emission tomography (PET) images is of great interest for proper diagnosis and therapy planning. However, standard segmentation techniques (manual or semi-automated) are operator dependent and time consuming while fully automated procedures are cumbersome or require complex mathematical development. The aim of this study was to segment PET images in a fully automated way by implementing a set of 12 automated thresholding algorithms, classical in the fields of ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2012 - IOP Publishing | Physics in Medicine and Biology
Esperanza Vergara‐Moragues, Francisco González‐Saiz, Óscar M. Lozano, Patricia Betanzos Espinosa, Fermín Fernández‐Calderón, Izaskun Bilbao-Acebos, Miguel Pérez‐García, Antonio Verdejo‐García,
This is a cross-sectional study of 227 cocaine dependent individuals in six different therapeutic communities (TCs) within a single treatment network in Andalusia (Spain). The primary aim of the study is to examine the prevalence of lifetime psychiatric comorbidity in this sample using the Psychiatric Research Interview for Substance and Mental Disorders (PRISM). Diagnoses were assessed 15-20 days after admission. The data indicate that more than 65% of the sample experienced a lifetime co-occurring ...
Tópico(s): Substance Abuse Treatment and Outcomes
2012 - Elsevier BV | Psychiatry Research
Esperanza Vergara‐Moragues, Francisco González‐Saiz, Óscar M. Lozano, Izaskun Bilbao Acedos, Fermín Fernández‐Calderón, Patricia Betanzos Espinosa, Antonio Verdejo‐García, Miguel Pérez‐García,
<i>Objective:</i> To estimate the prevalence of adult attention deficit/hyperactivity disorder (ADHD) in a sample of cocaine-dependent patients, and to examine the discriminant validity of the Barkley’s executive dysfunction scale in differentiating cocaine-dependent patients with and without ADHD. <i>Methods:</i> A cross-sectional design was used. A total of 166 cocaine-dependent subjects were assessed. The assessment instruments included: Conners’ Adult ADHD Diagnostic Interview ...
Tópico(s): Neural and Behavioral Psychology Studies
2011 - Karger Publishers | European Addiction Research
Antonio Verdejo‐García, P. Betanzos-Espinosa, Óscar M. Lozano, Esperanza Vergara‐Moragues, Francisco González‐Saiz, Fermín Fernández‐Calderón, Izaskun Bilbao-Acedos, Miguel Pérez‐García,
We aimed to explore the association between baseline executive functioning and treatment outcome in Therapeutic Communities (TCs).We used a longitudinal descriptive design: a baseline neuropsychological assessment was performed within the first 30 days of treatment in TCs. Once participants finished or abandoned treatment, the information about time of stay in treatment was computed for each individual. The study was conducted across six TCs located in the region of Andalusia (Spain): Cartaya, Almonte, ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2011 - Elsevier BV | Drug and Alcohol Dependence
Fermín Fernández‐Calderón, Óscar M. Lozano, Claudio Vidal Giné, Josefa Gutiérrez Ortega, Esperanza Vergara‐Moragues, Francisco González‐Saiz, Izaskun Bilbao,
Drug use in mainstream rave parties has been widely documented in a large number of studies. However, not much is known about drug use in underground raves. The purpose of this study is to find out the polysubstance use patterns at underground raves. Two hundred and fifty-two young people between the ages of 18 and 30 who went to underground raves were interviewed. They were given a questionnaire to collect information on drug use at raves. Ravers used a mean of 4.9 different drugs at the last rave ...
Tópico(s): Substance Abuse Treatment and Outcomes
2011 - SAGE Publishing | Journal of Drug Education
Francisco González‐Saiz, Óscar M. Lozano, Rosario Ballesta, Teresa C. Silva, M. Teresa Brugal, Izaskun Bilbao, Gregorio Barrio, Antònia Domingo‐Salvany, María J. Bravo, Luís de la Fuente, Grupo del Proyecto ItÍnere,
Aims: The purpose of this work is to study the validity of the Severity of Dependence Scale (SDS) construct by applying Rasch models to a non-clinical sample of heroin abusers. Subjects: 982 (73% men) young people 30 years old or under (mean age 25.9 years) participated. All of them were captured from the community in the metropolitan areas of Madrid, Barcelona and Seville, between April 2002 and December 2003. Analysis: Dimensionality of the scale and calibration of items were studied using the Rating ...
Tópico(s): Suicide and Self-Harm Studies
2008 - Taylor & Francis | Substance Use & Misuse
Francisco González‐Saiz, Óscar M. Lozano, Juana Martín Esteban, Izaskun Bilbao Acedos, Rosario Ballesta Gómez, Josefa Gutiérrez Ortega,
El objetivo de este trabajo es estimar la prevalencia de casos psiquiátricos en una muestra de pacientes con dependencia de opiáceos tratados con buprenorfina sublingual en régimen de comunidad terapéutica y describir su evolución durante el primer mes de tratamiento. Estudio observacional, longitudinal prospectivo. Se seleccionó a 119 pacientes con dependencia a opiáceos, de los que 46 aceptaron iniciar tratamiento con buprenorfina. Por motivos organizacionales, la evaluación psicopatológica se ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2011 - Elsevier BV | Revista de Psiquiatría y Salud Mental
Óscar M. Lozano, Antonio José Rojas Tejada, Cristino Pérez, Francisco González‐Saiz, Rosario Ballesta, Izaskun Bilbao,
The aim of this work is to show evidence of the validity of the Health-Related Quality of Life for Drug Abusers Test (HRQoLDA Test). This test was developed to measure specific HRQoL for drugs abusers, within the theoretical addiction framework of the biaxial model. The sample comprised 138 patients diagnosed with opiate drug dependence. In this study, the following constructs and variables of the biaxial model were measured: severity of dependence, physical health status, psychological adjustment ...
Tópico(s): Youth, Drugs, and Violence
2008 - Cologio Oficial de Psicólogos del Principado | Psicothema
Esperanza Vergara‐Moragues, Francisco González‐Saiz, Óscar M. Lozano, Fermín Fernández‐Calderón, Antonio Verdejo‐García, Patricia Betanzos Espinosa, Izaskun Bilbao Acedos, Miguel Pérez‐García,
Over the last years, the therapeutic community treatment with people who have cocaine problems and psychopathological comorbidity has been increasing and it is important to know more about the success of these treatments. The aim of this paper is to study the psychopathological profile of cocaine-dependent patients and its association with outcome variables. It is interviewed by the Psychiatric Research Interview for Substance and Mental Disorders (PRISM-IV) and the Conners’ Adult ADHD Diagnostic ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - | Adicciones
Izaskun Bilbao Acedos, Ortiz Rojas, Rosario Ballesta Gómez, Francisco González‐Saiz,
Diversos autores han puesto de relieve la importancia de incorporar a los estudios sobre tratamiento en drogodependencias indicadores que tomen en cuenta la percepción del paciente hacia el tratamiento y su satisfacción con el mismo. La percepción sobre el tratamiento influye sobre su aceptabilidad y, por lo tanto, sobre el seguimiento y la adherencia, modulando así su efectividad. El objetivo de este estudio es conocer la percepción y la satisfacción de los pacientes que participan en un estudio ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2009 - Elsevier BV | Trastornos Adictivos
Fermín Fernández‐Calderón, Mario Blanco-Rodríguez, Fernando Martín-Cazorla, Inmaculada Martínez-Téllez, Teresa Soriano-Ramón, Izaskun Bilbao-Acedos,
Background: This study aimed to (1) describe drug-induced deaths (DIDs) in Southern Spain (Andalusia) in terms of substances involved, sociodemographic characteristics, and circumstances of death, and (2) identify profiles by substances involved and their association with sociodemographic characteristics and circumstances of death. Methods: Observational study of 398 deceased in 2010/2011 in Andalusia suspected of DIDs. Medical examiner diagnoses considered the scene of death, regulatory forensic autopsy, ...
Tópico(s): Poisoning and overdose treatments
2016 - Taylor & Francis | Journal of Substance Use
Francisco González‐Saiz, Óscar M. Lozano, Juana Martín Esteban, Izaskun Bilbao Acedos, Rosario Ballesta Gómez, Josefa Gutiérrez Ortega,
The purpose of this work is to estimate the prevalence of psychiatric cases in a sample of opiate-dependent patients treated with sublingual buprenorphine in a therapeutic community regime, and to describe their progress during the first month of treatment. An observational, longitudinal, prospective study was conducted. Of the 119 opiatedependent patients selected, 46 agreed to start treatment with buprenorphine. For organisational reasons, the psychopathological assessment was carried out on 36 ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2011 - Elsevier BV | Revista de Psiquiatría y Salud Mental (English Edition)
Óscar M. Lozano, Izaskun Bilbao Acedos, Francisco González Saiz, Rosario Ballesta Gómez,
The measurement of perception and satisfaction with opiate substitute treatment programmes has concentrated mainly on evaluating the properties of the service offered at treatment centres. Beyond the health-care context, these programmes need to become part of the patient’s personal and social life for them to be followed. The purpose of this work is to offer a theoretical frame of reference for the construction of a scale for integral measurement of patient perception of opiate substitute treatments. ...
Tópico(s): Mental Health Treatment and Access
2008 - | Adicciones
Izaskun Zorita, Eider Bilbao, Arno Schad, Ibon Cancio, Manu Soto, Miren P. Cajaraville,
Metallothioneins (MTs) are metal-inducible proteins that can be used as biomarkers of metal exposure. In mussels two families of MT isoforms (MT10 and MT20) have been characterized. In this study, mussels (Mytilus galloprovincialis) were exposed to 200 ppb Cd and 40 ppb Cu for 2 and 9 days to characterize the tissue and isoform specificity of metal-induced MT expression. Non-radioactive in situ hybridization demonstrated that both MT isoforms were mainly transcribed in digestive tubule epithelial cells, ...
Tópico(s): Heavy Metal Exposure and Toxicity
2007 - Elsevier BV | Toxicology and Applied Pharmacology
Izaskun Elezgarai, A Bilbao, José Marı́a Mateos, Jon Jatsu Azkue, Rocı́o Benı́tez, Alexandra Osorio, Javier Díez‐García, Nagore Puente, F Doñate-Oliver, Pedro Grandes,
The existence of a neuronal-glial signalling through the activation of neurotransmitter receptors expressed in glia is well-documented. In excitatory synapses, glutamate released from presynaptic terminals activates not only postsynaptic receptors, but also ionotropic and metabotropic glutamate receptors localized in the glia ensheathing the synapses. The medial nucleus of the trapezoid body of the auditory system is involved in the localization of sounds in the space. In this nucleus, the large ...
Tópico(s): Ion channel regulation and function
2001 - Elsevier BV | Neuroscience
Roc�o Ben�tez, Óscar Fernández-Capetillo, Esther L�zaro, José Marı́a Mateos, Alexandra Osorio, Izaskun Elezgarai, Aurora Bilbao, Kurt Lingenhoehl, Herman van der Putten, David R. Hampson, Rainer Kühn, Thomas Kn√∂pfel, Pedro Grandes,
This study evaluates the localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of rats using preembedding immunocytochemical methods. At the light microscopic level, punctate labeling was evident in layers Ia and Ib of the piriform cortex, and immunolabeled fibers were present in layers II and III. Following bilateral destruction of the olfactory bulb, the density of labeled puncta in layer Ia decreased. These results suggest that the receptor is present on the terminals ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2000 - Wiley | The Journal of Comparative Neurology
Izaskun Bilbao Acedos, Joan Carles March Cerdá, María Ángeles Prieto Rodríguez,
La metodología cualitativa, propia en su origen de las ciencias sociales, se ha ido incorporando progresivamente a la investigación en salud, ante el escepticismo de muchos y la admiración de otros. Todavía hoy en día la validez y fiabilidad de las técnicas cualitativas de recogida y análisis de datos es cuestionada por una parte importante de los investigadores de ciencias de la salud y su utilización provoca la duda entre revisores y otros miembros de la comunidad científica. Este artículo presenta ...
Tópico(s): Qualitative Research Methods and Ethics
2002 - Ministry of Health of Spain | Revista Española de Salud Pública
Joana del Hoyo-Bilbao, Izaskun Orue, Manuel Gámez‐Guadix, Esther Calvete,
This study aimed to address how multiple risk factors that were previously related and derived from ecological levels, when taken together, could explain child-to-mother and child-to-father violence. A total of 298 Spanish adolescents (140 girls) who had committed CPV, with a mean age of 15.91 (SDage = 1.89), offender residents of specialized closed institutions for adolescents who had aggressed their parents (49.5%) and educational centres (50.6%) completed all measures. Both models obtained adequate ...
Tópico(s): Crime Patterns and Interventions
2019 - Colegio Oficial de Psicólogos de Madrid | The European Journal of Psychology Applied to Legal Context
Esther Villar-Rodríguez, Javier Del Ser, Izaskun Oregi, Miren Nekane Bilbao, Sergio Gil-López,
The advent and progressive deployment of the so-called Smart Grid has unleashed a profitable portfolio of new possibilities for an efficient management of the low-voltage distribution network supported by the introduction of information and communication technologies to exploit its digitalization. Among all such possibilities this work focuses on the detection of anomalous energy consumption traces: disregarding whether they are due to malfunctioning metering equipment or fraudulent purposes, strong ...
Tópico(s): Water Systems and Optimization
2017 - Elsevier BV | Energy
Jesús Mateo, Izaskun Bilbao, J.J. Vaquero, Jesús Ruíz‐Cabello, Samuel España,
Positron emission tomography (PET) is an important technique in cardiovascular research. Vascular inflammation detected by fluorodeoxyglucose (FDG)-PET has been shown to predict cardiovascular (CV) events independent of traditional risk factors and is also highly associated with overall burden of atherosclerosis. The use of PET imaging in mouse models of atherosclerosis is challenged by the reduced size of the scanned organs. However, the last generation of dedicated PET scanners has an improved spatial ...
Tópico(s): Cardiovascular Disease and Adiposity
2015 - Springer Science+Business Media | Methods in molecular biology
Fermín Fernández‐Calderón, Óscar M. Lozano, Izaskun Bilbao Acedos, Antonio José Rojas Tejada, Claudio Vidal Giné, Esperanza Vergara Moragues, Francisco González‐Saiz,
Objetivos: El presente estudio tiene como objetivo describir los efectos positivos y negativos percibidos por asistentes a fiestas rave underground, y analizar las relaciones existentes entre las drogas consumidas y los efectos percibidos.Método: estudio realizado entre 252 asistentes a 22 fiestas raves underground celebradas en Andalucía, entre los meses de mayo y octubre de 2008. Se han aplicado contrastes de proporciones y regresiones logísticas.Resultados: Los resultados muestran que las drogas ...
Tópico(s): Cannabis and Cannabinoid Research
2012 - | African journal of rhetoric
Esperanza Vergara‐Moragues, Francisco González‐Saiz, Óscar M. Lozano, Izaskun Bilbao-Acedos, Fermín Fernández‐Calderón, P. Betanzos-Espinosa, Antonio Verdejo‐García, Miguel Pérez‐García,
Estimación de la prevalencia del trastorno por déficit de atención e hiperactividad (TDAH) del adulto en una muestra de dependientes de cocaína y evaluación de la utilidad de los síntomas de funcionamiento ejecutivo de Barkley para diferenciar entre pacientes dependientes de cocaína con y sin TDAH. Diseño observacional transversal. Se evaluó un total de 70 sujetos dependientes de cocaína que ingresaron para tratamiento en una comunidad terapéutica. Los sujetos seleccionados fueron citados para una ...
Tópico(s): Psychological Treatments and Disorders
2010 - Elsevier BV | Trastornos Adictivos
Izaskun Álvarez-Meaza, Enara Zarrabeitia Bilbao, Rosa María Río Belver, Gaizka Garechana,
The strengthening of measures to reduce greenhouse gas emissions meant that manufacturing scheduling had to acquire a green approach. The need to reduce energy consumption becomes necessary for companies to achieve sustainable development. Therefore, a new challenge for the scientific community was foreseen, researching new algorithms or knowledge hubs to achieve green scheduling. Green scheduling may be considered one of the principles of green manufacturing, aimed at minimizing environmental damage ...
Tópico(s): Digital Transformation in Industry
2021 - Elsevier BV | Technology in Society
Izaskun Álvarez-Meaza, Enara Zarrabeitia Bilbao, Rosa María Río Belver, Gaizka Garechana,
The fuel-cell electric vehicle (FCEV) has been defined as a promising way to avoid road transport greenhouse emissions, but nowadays, they are not commercially available. However, few studies have attempted to monitor the global scientific research and technological profile of FCEVs. For this reason, scientific research and technological development in the field of FCEV from 1999 to 2019 have been researched using bibliometric and patent data analysis, including network analysis. Based on reports, ...
Tópico(s): Advanced Battery Technologies Research
2020 - Multidisciplinary Digital Publishing Institute | Sustainability
Joana del Hoyo-Bilbao, Izaskun Orue, Esther Calvete,
Abstract This study examined the longitudinal relationships between three psychopathic trait dimensions (callous-unemotional, CU; grandiose-manipulative, GM; and impulsive-irresponsible, II) and their interaction in the prediction of psychological and physical child-to-parent violence (CPV). Furthermore, the study examined whether the predictive relationships were different for boys and girls. A total of 765 adolescents (463 girls), with a mean age of 15.28 years ( SD = 1.04), completed measures of the ...
Tópico(s): Intimate Partner and Family Violence
2021 - Springer Science+Business Media | Journal of Psychopathology and Behavioral Assessment
Itziar Martínez de Alegría Mancisidor, Rosa María Río Belver, Enara Zarrabeitia Bilbao, Izaskun Álvarez-Meaza,
This paper aims to identify more simplified and appropriate energy performance indicators (EPIs) for residential buildings during their operational stage. The Spanish Energy Performance Certification methodology is used to evaluate the energy performance rate (EPR) of a selected sample of Passive House (PH) buildings. Results of the study indicate: all the certified PH buildings analyzed are nearly zero-energy buildings (NZEBs) under the Spanish certification system; disaggregate indicators (particularly ...
Tópico(s): Sustainable Building Design and Assessment
2021 - Elsevier BV | Energy Policy