Katsuhisa Yamada, S Araki, M. Tamura, Izumi Sakai, Yukiko Takahashi, Hidetoshi Kashihara, Suminori Kono,
Tópico(s): Smoking Behavior and Cessation
1997 - Springer Science+Business Media | Cancer Causes & Control
Shigehiro Mori, Izumi Sakai, Toyohiko Aoyama, Takayuki Shioiri,
The stable and safe compound trimethylsilyldiazomethane (TMSCHN2), which is useful for organic synthesis, was prepared in high yield by diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate [DPPA, (C6H5O)2-P (O) N3].
Tópico(s): Cyclopropane Reaction Mechanisms
1982 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Izumi SAKAI, Hajime ISHIMARU, G. Horikoshi,
‘Helicoflex’ is a new type of flexible and elastic metal 0-ring. In this paper relations between sealing performance and the condition of the sealing surfaces are investigated for the Helicoflex gasket. Two kinds of sealing mechanism were found according to the surface conditions of the flange. In particular, when the surface of flange is superfinished, the soft metal sheet of the Helicoflex in contact with flange surface flows in the gap between elastic core and flange surface as the flanges are ...
Tópico(s): Vibration and Dynamic Analysis
1982 - Elsevier BV | Vacuum
Yasuharu Imai, Masahiko Ohsawa, Hideo Tanaka, Shinji Tamura, Hiroyuki Sugawara, Jun Kuyama, Kazuto Fukada, Takahiro Yonezawa, Yuji Matszawa,
... 1852. MEDLINE CASPubMedWeb of Science®Google Scholar 21 Izumi T, Sakai R, Miura Y, Okamoto H. Primary hepatosplenic lymphoma: ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2002 - Lippincott Williams & Wilkins | Hepatology
O. N. Koroleva, Михаил Михайлович Дeмин, V. I. Mazhukin, V. I. Mazhukin,
... the atomistic approach. The Stillinger–Weber and Kumagai–Izumi–Hara–Sakai interaction potentials were used for modeling. The results ...
Tópico(s): Silicon Nanostructures and Photoluminescence
2021 - IOP Publishing | Journal of Physics Conference Series
V. S. Dozhdikov, A. Yu. Basharin, P. R. Levashov,
... and Tersoff potentials in the modification by Kumagai-Izumi-Hara-Sakai a good coincidence with experimental data on crystalline ...
Tópico(s): Theoretical and Computational Physics
2012 - American Institute of Physics | The Journal of Chemical Physics
Kunihiro Sumoto, Nobuko Mibu, Kazumi Yokomizo, Ai Yuzuriha, Marie Otsubo, Yuna Kawaguchi, Marina Sano, Izumi Sakai, Keita Nakayama, Jian-Rong Zhou,
Tópico(s): Synthesis of heterocyclic compounds
2017 - Elsevier BV | Heterocycles
H. Ohta, Nobuyuki Sakai, Izumi Nagata, Hiroshi Sakai, Asako Shindo, H. Kikuchi,
Tópico(s): Ophthalmology and Eye Disorders
2001 - Springer Science+Business Media | Acta Neurochirurgica
Kunihiro Sumoto, Nobuko Mibu, Kazumi Yokomizo, Junko Matsuyama, Syoko Tomonaga, Izumi Sakai, Yuki Kawano, Yumemi Matsumoto, Yuka Fujita, Yusuke Inoue, Masaya Iida, Kaneto Hashiguchi, Jianrong Steve Zhou, Makoto Furutachi, Kanae Yamada, Ryo Sato,
We report a new route to the preparation of C3-symmetrical multivalent hybrid-type molecules having a tris-aminoethylamine (TAEA) linker group and 1,3,5-triazine recognition moieties in the molecule and we also report the results of biological evaluation of their anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity against Vero cells.Among the tested compounds, a new mid-size C2-symmetrical multivalent hybrid-type molecule (10aq) showed a high level of anti-HSV-1 activity (EC50 = ...
Tópico(s): DNA and Nucleic Acid Chemistry
2019 - Elsevier BV | Heterocycles
Kaho Morii, Patricio Sanhueza, Fumitaka Nakamura, Qizhou Zhang, G. Sabatini, H. Beuther, Xing Lu, Shanghuo Li, Guido Garay, James M. Jackson, Fernando A. Olguin, Daniel Tafoya, Ken’ichi Tatematsu, Natsuko Izumi, Takeshi Sakai, Andréa Silva,
The initial conditions found in infrared dark clouds (IRDCs) provide insights on how high-mass stars and stellar clusters form. We have conducted high-angular resolution and high-sensitivity observations toward thirty-nine massive IRDC clumps, which have been mosaicked using the 12m and 7m arrays from the Atacama Large Millimeter/submillimeter Array (ALMA). The targets are 70 $\mu$m dark massive (220-4900 $M_\odot$), dense ($>$10$^4$ cm$^{-3}$), and cold ($\sim$10-20K) clumps located at distances between 2 and ...
Tópico(s): Astronomy and Astrophysical Research
2023 - IOP Publishing | The Astrophysical Journal
Yutaro Tamiya, Shingo Matsumoto, Yoshitaka Zenke, Kiyotaka Yoh, Takaya Ikeda, Yuji Shibata, Terufumi Kato, Kazumi Nishino, Atsushi Nakamura, Naoki Furuya, Shingo Miyamoto, Shoichi Kuyama, Shogo Nomura, Takashi Ikeno, Hibiki Udagawa, Eri Sugiyama, Kaname Nosaki, Hiroki Izumi, Tetsuya Sakai, Naozumi Hashimoto, Kōichi Goto,
KRAS G12C is an oncogenic driver mutation, accounting for approximately 14% of Caucasian patients with non-small cell lung cancer (NSCLC). Recently, several KRAS G12C-targeted drugs have been developed; however, the clinico-genomic characteristics of NSCLC patients with KRAS G12C remain unclear.Based on the large-scale prospective lung cancer genomic screening project (LC-SCRUM-Asia) database, the clinico-genomic characteristics and therapeutic outcomes of NSCLC patients with KRAS G12C were evaluated. ...
Tópico(s): Cancer Mechanisms and Therapy
2022 - Elsevier BV | Lung Cancer
G. Sabatini, S. Bovino, Patricio Sanhueza, Kaho Morii, Shanghuo Li, E. Redaelli, Qizhou Zhang, Xing Lu, Siyi Feng, Daniel Tafoya, Natsuko Izumi, Takeshi Sakai, Ken’ichi Tatematsu, David Allingham,
Abstract Studying the physical and chemical properties of cold and dense molecular clouds is crucial for the understanding of how stars form. Under the typical conditions of infrared dark clouds, CO is removed from the gas phase and trapped onto the surface of dust grains by the so-called depletion process. This suggests that the CO-depletion factor ( f D ) can be a useful chemical indicator for identifying cold and dense regions (i.e., prestellar cores). We have used the 1.3 mm continuum and C 18 O ( ...
Tópico(s): Atmospheric Ozone and Climate
2022 - IOP Publishing | The Astrophysical Journal
Kaho Morii, Patricio Sanhueza, Fumitaka Nakamura, James M. Jackson, Shanghuo Li, H. Beuther, Qizhou Zhang, Siyi Feng, Daniel Tafoya, Andrés E. Guzmán, Natsuko Izumi, Takeshi Sakai, Xing Lu, Ken’ichi Tatematsu, Satoshi Ohashi, Andréa Silva, Fernando A. Olguin, Y. Contreras,
Abstract With a mass of ∼1000 M ⊙ and a surface density of ∼0.5 g cm −2 , G023.477+0.114, also known as IRDC 18310-4, is an infrared dark cloud (IRDC) that has the potential to form high-mass stars and has been recognized as a promising prestellar clump candidate. To characterize the early stages of high-mass star formation, we have observed G023.477+0.114 as part of the Atacama Large Millimeter/submillimeter Array (ALMA) Survey of 70 μ m Dark High-mass Clumps in Early Stages. We have conducted ∼1.″2 resolution ...
Tópico(s): Atmospheric Ozone and Climate
2021 - IOP Publishing | The Astrophysical Journal
Mikiko Shimizu, Kenji Miyamoto, Yunosuke Nishihara, Gaku Izumi, Shuji Sakai, Kei Inai, Toshio Nishikawa, Toshio Nakanishi,
Tópico(s): Infective Endocarditis Diagnosis and Management
2015 - Springer Science+Business Media | Heart and Vessels
Megumi Ishibashi, Yoshihiro Izumi, Miho Sakai, Takashi Ando, Eiichiro Fukusaki, Takeshi Bamba,
Recently, a generally applicable screening method for multiresidue pesticide analysis, which is simple, quick, and accurate and has a reliable performance, is becoming increasingly important for food safety and international trade. This paper proposes a high-throughput screening methodology that enables the detection of multiresidue pesticides using supercritical fluid chromatography coupled to a high-performance benchtop quadrupole Orbitrap mass spectrometry (SFC/Q Exactive) and an automated library- ...
Tópico(s): Analytical chemistry methods development
2014 - American Chemical Society | Journal of Agricultural and Food Chemistry
Kiyoshi Migita, Yuichi Izumi, Yuka Jiuchi, Hideko Kozuru, Chieko Kawahara, Mitsuru Izumi, Takatsugu Sakai, Motoki Nakamura, Satoru Motokawa, Tadashi Nakamura, Atsushi Kawakami,
The Janus kinase inhibitor tofacitinib is currently being investigated as a disease-modifying agent in rheumatoid arthritis (RA). We investigated the in-vivo effects of tofacitinib treatment for 4 weeks on elevated circulating acute-phase serum amyloid (SAA) levels in 14 Japanese patients with RA. SAA levels fell from 110·5 ± 118·5 μg/ml (mean ± standard deviation) at treatment initiation to 15·3 ± 13·3 μg/ml after 4 weeks treatment with tofacitinib. The reduction in SAA levels was greater in patients receiving ...
Tópico(s): Peripheral Neuropathies and Disorders
2013 - Oxford University Press | Clinical & Experimental Immunology
Lu Zheng, Masanari Izumi, Yusuke Sakai, Ritsuko Eguchi, Hidenori Goto, Yasuhiro Takabayashi, Takashi Kambe, Taiki Onji, Shingo Araki, Tatsuo C. Kobayashi, Jung-Eun Kim, Akihiko Fujiwara, Yoshihiro Kubozono,
Alkali-metal-intercalated FeSe materials, (NH${}_{3}$)${}_{\mathrm{y}}$${M}_{0.4}$FeSe ($M$: K, Rb, and Cs), have been synthesized using the liquid NH${}_{3}$ technique. (NH${}_{3}$)${}_{\mathrm{y}}$Cs${}_{0.4}$FeSe shows a superconducting transition temperature (${T}_{\mathrm{c}}$) as high as 31.2 K, which is higher by 3.8 K than the ${T}_{\mathrm{c}}$ of nonammoniated Cs${}_{0.4}$FeSe. The ${T}_{\mathrm{c}}$s of (NH${}_{3}$)${}_{\mathrm{y}}$K${}_{0.4}$FeSe and (NH${}_{3}$)${}_{\mathrm{y}}$Rb${}_{0.4}$FeSe ...
Tópico(s): Rare-earth and actinide compounds
2013 - American Physical Society | Physical Review B
Tomoo Yoshie, Shin Nishiumi, Yoshihiro Izumi, Aya Sakai, Jun Inoue, Takeshi Azuma, Masaru Yoshida,
Mutation of the APC gene occurs during the early stages of colorectal cancer development. To obtain new insights into the mechanisms underlying the aberrant activation of the Wnt pathway that accompanies APC mutation, we carried out a gas chromatography-mass spectrometry-based semiquantitative metabolome analysis. In vitro experiments comparing SW480 cells expressing normal APC and truncated APC indicated that the levels of metabolites involved in the latter stages of the intracellular tricarboxylic ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - Wiley | Cancer Science
Takashi YOKOYAMA, Mårten Olsson, Satoshi IZUMI, Shinsuke Sakai,
Tópico(s): Mechanical Engineering and Vibrations Research
2012 - Elsevier BV | Engineering Failure Analysis
Hiro TANAKA, Yoji Shibutani, Satoshi IZUMI, Shuichi Sakai,
A range of modes of mobility for spatial structures can be achieved by selecting the rotational features of the joints. Similar mechanical characteristics are observed in structures ranging from molecules to buildings. The local rotational manner in a solid with an internal spatial structure performs a key part in dictating the nature of structural deformability. In this paper, we propose a two-dimensional repetitive motion structure assembled with straight rigid bars connected by 8-bar pivot joints. ...
Tópico(s): Modular Robots and Swarm Intelligence
2012 - Elsevier BV | International Journal of Solids and Structures
Koichi Shima, Satoshi IZUMI, Shinsuke Sakai,
Using reaction pathway sampling, we have investigated the shear stress dependences of the activation energies of shuffle-set and glide-set dislocation nucleation from a sharp corner in silicon. The gradient of the glide-set dislocation curve is lower than that of the shuffle-set dislocation, and the athermal stress of glide-set dislocation is largely higher than that of shuffle-set dislocation. As a result, the two curves have a cross point, which means that shuffle-set dislocation is likely nucleated ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2010 - American Institute of Physics | Journal of Applied Physics
Shotaro HARA, Satoshi IZUMI, Shinsuke Sakai,
Threshold strain required for a thermally activated dislocation nucleation from a Ni surface step has been measured using an atomistic-based reaction pathway analysis. We show that the saddle-point configuration and the stress-dependent activation energy are strongly influenced by the presence of a surface step. Our results provide insight into the previous experimental findings concerning the mechanism on a coherency loss at the Ni∕Cu(001) interface. We conclude that the coherency strain caused ...
Tópico(s): Semiconductor materials and devices
2009 - American Institute of Physics | Journal of Applied Physics
Hasan Aftab SAEED, Satoshi IZUMI, Shinsuke Sakai, Shigeyuki Haruyama, Masato Nagawa, Hideki NODA,
This paper introduces a new all-metal gasket that incorporates strategically located circumferential annular lips that form seal lines with the flanges. This gasket, named Super Seal Gasket, by virtue of its special shape, makes use of the material's spring effect, resulting in sealing performance. This change in approach, from the traditional one based on material development to one of mechanical design, brings with it the need for optimization of the different design parameters for leakage performance. ...
Tópico(s): Mechanical Engineering and Vibrations Research
2008 - Japan Society Mechanical Engineers | Journal of Solid Mechanics and Materials Engineering
Yosuke Kimura, H. Matsuzaki, I Ohtani, E Morita, Mitsuru Izumi, N. Sakai, I. Hirabayashi, M. Miki, M. KITANO, Tetsuya Ida,
Pulsed-field magnetization is a useful magnetization technique for high-temperature superconductivity bulk crystals for practical applications. However, the trapped magnetic flux is reduced due to the temperature increase from the mobile flux, and the distribution of the flux density is considerably distorted in the a–b crystallographic axes plane. We present two proposals to improve the trapped magnetic flux and its distribution upon pulsed-field magnetization. Firstly, split-type vortex pulsed ...
Tópico(s): Magnetic properties of thin films
2006 - IOP Publishing | Superconductor Science and Technology
Satoshi IZUMI, Shinsuke Sakai,
Martin's method, which is used to determine the internal displacement of atomic systems and elastic constants, is applied to the Tersoff potential. The potential is modified to provide an accurate description of the high-temperature elastic properties of silicon. The elastic constants of crystalline silicon were investigated at both low and high temperatures. Results were verified using the statistical thermodynamic method, i. e., 'Fluctuation formula'. It was found that values of elastic constants ...
Tópico(s): Thermal properties of materials
2004 - Japan Society Mechanical Engineers | JSME International Journal Series A
Yotaro Izumi, Hiromi Sakai, Takehiro Kose, Kenichi Hamada, Shinji Takeoka, Akira Yoshizu, Hirohisa Horinouchi, Ryoichi Kato, Hiroyuki Nishide, E. Tsuchida, Koichi Kobayashi,
Encapsulation of hemoglobin within a liposome is one of the strategies in the development of artificial oxygen carriers. It maintains the oxygen transporting properties of hemoglobin and, at the same time, eliminates the side effects of cell free hemoglobin. Hemoglobin vesicles (HbV) are a type of liposome encapsulated hemoglobin. They have a particle size of approximately 250 nm, a hemoglobin concentration of 10 g/ dl, and the oxygen affinity, P50, is regulated to 32 Torr. In this study the authors ...
Tópico(s): Neonatal Health and Biochemistry
1997 - Lippincott Williams & Wilkins | ASAIO Journal
Yotaro Izumi, Hiromi Sakai, Kenichi Hamada, Shinji Takeoka, Takeshi Yamahata, Ryoichi Kato, Hiroyuki Nishide, Eishun Tsuchida, Koichi Kobayashi,
Objectives To evaluate the oxygen transporting capabilities of hemoglobin vesicles by studying the physiologic responses to exchange transfusion with hemoglobin vesicles in anesthetized rats. Exchange transfusions with phosphate buffered saline, hemoglobin vesicles containing methemoglobin (and therefore, deprived of oxygen transporting capabilities), and washed rat red blood cells were used as controls. Design Prospective, randomized, controlled trial. Setting Department of Surgery, School of Medicine, ...
Tópico(s): Methemoglobinemia and Tumor Lysis Syndrome
1996 - Lippincott Williams & Wilkins | Critical Care Medicine
Hidenori Yoshino, Yoshinobu Izumi, Kazuyoshi Sakai, Hikaru Takezawa, Isao Matsuura, Hironobu Maekawa, Michio Yazawa,
We present here the first evidence, obtained by the use of solution X-ray scattering, of the solution structure of yeast calmodulin, a poor activator of vertebrate enzymes. The radius of gyration of yeast calmodulin decreased from 21.1 to 19.9 Å when excess Ca2+ ions were added. The profiles of the pair-distribution function suggested that yeast calmodulin without Ca2+ has a dumbbell-like shape which changes toward a rather asymmetric globular shape, from its dumbbell shape, by the binding of Ca2+. ...
Tópico(s): Plant biochemistry and biosynthesis
1996 - American Chemical Society | Biochemistry
Kazuhiko Okamura, Ieyoshi Kobayashi, Kou Matsuo, Kunihisa Taniguchi, Yukiko Ishibashi, Toshio Izumi, Hidetaka Sakai,
Tópico(s): Pain Mechanisms and Treatments
1994 - Elsevier BV | Archives of Oral Biology
Hiroshi Miki, T. Ohmameuda, Masayuki Kumon, Kunihiro Asada, T. Sugano, Yasuhisa Ōmura, K. Izumi, T. Sakai,
A deep submicrometer gate MOSFET with fully depleted channel was fabricated using ultrathin Si film on SIMOX (separation by implanted oxygen) substrates. Ultrathin films with thicknesses down to 30 nm are shown to be effective in reduction of the short-channel effect. Thus, deep submicrometer gate MOSFETs with steep subthreshold slopes and threshold voltages insensitive to drain voltage were realized. The propagation delay of a CMOS inverter on an ultrathin SIMOX substrate was measured by a 51-stage ...
Tópico(s): Nanowire Synthesis and Applications
1991 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electron Devices