Emma Ligtermoet, Cristina E. Ramalho, Julia Foellmer, Natasha Pauli,
Globally, there is growing recognition of the potential of road verges to contribute to urban greening and ecosystem service provision, beyond their original functions of utility provision and public access. Numerous, diverse stakeholders are involved in their management, yet their shared and diverging perspectives on verge greening are poorly understood. This research examined the perspectives on road verge greening by 30 respondents from eight stakeholder groups from the Perth Metropolitan Area, ...
Tópico(s): Urban Agriculture and Sustainability
2022 - Elsevier BV | Urban forestry & urban greening
Produção Nacional
Rachel Esteves Soeiro, Rubens Bedrikow, Bruna Daniele de Souza Ramalho, Ana Júlia Schmidt Niederauer, Clarissa Vasconcellos de Souza, Carolina Stivanin Previato, Diego Bonaparte Martins, Thaís Machado Dias, A.R.R. Freitas, Giuliano Dimarzio,
Atenção Primária à Saúde e a pandemia de COVID-19: reflexão para a prática
Tópico(s): Health, Nursing, Elderly Care
2020 - | InterAmerican Journal of Medicine and Health
Produção Nacional
Revisado por pares
Juniana de Almeida Mota Ramalho, Jonathan Lachal, Júlia Sursis Nobre Ferro Bucher-Maluschke, Marie-Rose Moro, Anne Révah-Lévy,
Obesity in adolescence is a major public health issue in Brazil. The relation between food and family plays an important role in both prevention and treatment, although its precise effect has not been clearly established. The purpose of this study is to investigate the meanings of food for Brazilian obese adolescents and their parents. Semi-structured interviews were conducted with 19 individuals from two medical centers in Fortaleza-CE, Brazil: seven adolescents with obesity (six girls and one boy ...
Tópico(s): Health and Lifestyle Studies
2015 - Elsevier BV | Appetite
Produção Nacional
Revisado por pares
Ricardo Lima, Célio Cortinhas Filho, Carlos Martins Ferreira Filho, Mauricio Vaisman, Alexandre Cossenza, Caroline Pinto Rebello, Carolina de Andrade Leite, Danilo de Oliveira Tavares, Júlia Falconiere Paredes Ramalho,
The case of a woman hospitalized due to COVID-19 is presented. The patient developed a severe macrophage activation syndrome diagnosed by bone marrow biopsy, which did not respond to immunoglobulin therapy.
Tópico(s): Parvovirus B19 Infection Studies
2020 - Elsevier BV | Respiratory Medicine Case Reports
Produção Nacional
Revisado por pares
Simone May, Racine Tadeu Araújo Prado,
... Acknowledgements The authors are grateful to Ana Maria Ramalho de Paula, Giselle Ibette Silva Lopez Lopes, Júlia Taeko U. Yoshida and Anita Scorsofava from Adolfo ...
Tópico(s): Urban Stormwater Management Solutions
2006 - Taylor & Francis | Urban Water Journal
Produção Nacional
Revisado por pares
Raquel de Oliveira Lopes, Patrícia Maia Pereira, Aline Ramalho Brandão Pereira, Keysson Vieira Fernandes, Julia Finamor Carvalho, Alexandre da Silva de França, Richard H. Valente, Manuela da Silva, Viridiana Santana Ferreira-Leitão,
Atrazine is the most common herbicide applied in crops of economic relevance, such as sugar cane, soybean, and corn. Atrazine and its derivatives desethylatrazine (DEA) and desisopropylatrazine (DIA) are toxic to the environment, affecting animal and human health. Thus, this study aimed to evaluate the degradation of atrazine and its derivatives by the fungus Pleurotus ostreatus INCQS 40310, as well as the potential of the enzymes involved in this process. P. ostreatus INCQS 40310 was able to degrade ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2020 - Taylor & Francis | Biocatalysis and Biotransformation
Produção Nacional
Revisado por pares
Silvio Antônio Garbelotti, Paulo Roberto Garcia Lucareli, Amâncio Ramalho Júnior, Wagner de Godoy, Milena Bernal, Júlia María D’Andréa Greve,
Diagnosis of lumbar spinal stenosis (LSS) is based on clinical examination and imaging. The aim of this study was to evaluate the influence of 3D gait analysis as a tool in the differential diagnosis of LSS. Fourteen patients participated in the study that consisted of three phases: (1) capture six gait cycles after rest, (2) walk on a treadmill for a maximum of 20 min, (3) capture six gait cycles after effort. From these data, the kinematic variables were compared with the perception of pain and the ...
Tópico(s): Sports injuries and prevention
2014 - Elsevier BV | Gait & Posture
Carlos Faro, Miguel Ramalho‐Santos, Paula Verı́ssimo, José Pissarra, Carlos Frazão, Júlia Costa, Xinli Lin, Jordan Tang, Euclides Pires,
Cardosins are aspartic proteinases of the flowers of Cynara cardunculus L. These flowers have economical relevance in Portugal since they are traditionally used in the manufacture of highly appreciated ewe cheeses such as Serra, Azeitäo and Serpa. Although the milk-clotting activity of the cardoon has been exploited for centuries, the biochemistry of the process was relatively unknown until some years ago when we and other laboratories started to study both basic and applied aspects of the cardoon ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
1998 - Springer Nature | Advances in experimental medicine and biology
Produção Nacional
Revisado por pares
Mônica Viégas Andrade, Kenya Noronha, Bernardo P. C. Diniz, Gilvan Ramalho Guedes, Lucas Resende de Carvalho, Valéria A. Silva, Júlia Almeida Calazans, André Soares Santos, Daniel N. Silva, Márcia C. Castro,
Abstract Background Quantifying disease costs is critical for policymakers to set priorities, allocate resources, select control and prevention strategies, and evaluate the cost-effectiveness of interventions. Although malaria carries a very large disease burden, the availability of comprehensive and comparable estimates of malaria costs across endemic countries is scarce. Methods A literature review to summarize methodologies utilized to estimate malaria treatment costs was conducted to identify ...
Tópico(s): Mosquito-borne diseases and control
2022 - BioMed Central | Malaria Journal
Produção Nacional
Revisado por pares
Katia Júlia de Almeida, Teodorico C. Ramalho, Žilvinas Rinkevičius, Olav Vahtras, Hans Ågren, Amary César,
Specific and basicity solvent effects on the visible near-infrared electronic transitions and the electron paramagnetic resonance (EPR) parameters of the copper(II) acetylacetonate complex, Cu(acac)2, have been investigated at the density functional theory level. The computed absorption transitions as well as the EPR parameters show a strong dependence on the direct coordination environment around the Cu(II) complex. High solvatocromic shifts are observed for 3d-3d transitions, with the highest effect ...
Tópico(s): Magnetism in coordination complexes
2011 - American Chemical Society | The Journal of Physical Chemistry A
Produção Nacional
Revisado por pares
Katia Júlia de Almeida, Teodorico C. Ramalho, J.L. Neto, Régis T. Santiago, V. C. Felicíssimo, Hélio A. Duarte,
The issue of reactivity differences of the ions Nb+ and Nb2+ toward methane (CH4 + Nb+ → NbCH2+ + H2 and CH4 + Nb2+ → NbCH22+ + H2) is addressed using CCSD(T)//MP2 and CCSD(T)//B3LYP calculations. A thorough description of the reaction mechanisms and analyses of the geometrical structures, chemical bonds, and molecular orbitals provide important insights into the chemistry of the niobium species. The overall results indicate highly labile kinetics and more favorable thermochemical conditions for Nb2+. The NBO, ...
Tópico(s): Catalytic Processes in Materials Science
2013 - American Chemical Society | Organometallics
Produção Nacional
Revisado por pares
Aline de Oliveira Ramalho, Júlia Drummond de Camargo, Eliane Mazócoli, Claudia Matias Rentes Barbosa, Nilda Rosa Oliveira Prado, Alessandra Marin,
Objetivo:Relatar a experiência da utilização de sala de escape como estratégia educacional e de sensibilização para prevenção de lesão por pressão no contexto hospitalar. Métodos: Trata-se de um relato de experiência decorrente de atividade desenvolvida em novembro de 2021, com profissionais da equipe multiprofissional de um hospital filantrópico de grande porte localizado na região metropolitana de São Paulo (SP), Brasil. Resultados: Realizou-se o jogo como estratégia educacional associado a outras ...
Tópico(s): Healthcare during COVID-19 Pandemic
2022 - | Revista Estima
Produção Nacional
Revisado por pares
Julia Ramalho Amalio da Silva Breder, Paulo Alonso Garcia Alves, Mário Lúcio Cordeiro Araujo, Bárbara Gomes Pires, Priscila Valverde, Daniel Bulzico, Fernanda Andrade Accioly, Rossana Corbo, Mário Vaisman, Fernanda Vaisman,
A sharp increase in pediatric thyroid cancer incidence is observed during adolescence, driven mainly by girls. Differences in disease presentation across sexual maturity stages raise the question of whether sex steroids have a role in the heterogeneity. The aims of this study were to analyze the influence of puberty and sex on clinical presentation and prognosis and to evaluate the correlation between the expression of sex hormone receptors.Clinical records and immunohistochemical of specimens from ...
Tópico(s): Estrogen and related hormone effects
2022 - | European Thyroid Journal
Julia Gorelik, Andrew Shevchuk, Michal Ramalho, M. Elliott, Lei Chang, C. F. Higgins, Max J. Lab, David Klenerman, N Krauzewicz, Yuri E. Korchev,
We have developed a method for simultaneous recording of high-resolution topography and cell surface fluorescence in a single scan which we call scanning surface confocal microscopy. The resolution of the system allows imaging of individual fluorescent particles in the nanometer range on fixed or live cells. We used this technique to record the interaction of single virus-like particles with the cell surface and demonstrated that single particles sink into the membrane in invaginations reminiscent ...
Tópico(s): Viral Infections and Immunology Research
2002 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Kerry L. Howell, Ana Hilário, A. Louise Allcock, David M. Bailey, Maria Baker, Malcolm R. Clark, Ana Colaço, Jon Copley, Erik E. Cordes, Roberto Danovaro, Awantha Dissanayake, Elva Escobar‐Briones, Patricia Esquete, Austin J. Gallagher, Andrew R. Gates, Sylvie M. Gaudron, Christopher R. German, Kristina M. Gjerde, Nicholas D. Higgs, Nadine Le Bris, Lisa A. Levin, Elisabetta Manea, Craig R. McClain, Lénaïck Menot, Nélia C. Mestre, Anna Meta×as, Rosanna Milligan, Agnes Muthumbi, Bhavani E. Narayanaswamy, Sofia P. Ramalho, Eva Ramírez-Llodra, Laura M. Robson, Alex D. Rogers, Javier Sellanes, Julia D. Sigwart, Kerry Sink, Paul V. R. Snelgrove, Paris V. Stefanoudis, Paulo Yukio Gomes Sumida, Michelle L. Taylor, Andrew R. Thurber, Rui P. Vieira, Hiromi Watanabe, Lucy C. Woodall, Joana R. Xavier,
The ocean plays a crucial role in the functioning of the Earth System and in the provision of vital goods and services. The United Nations (UN) declared 2021–2030 as the UN Decade of Ocean Science for Sustainable Development. The Roadmap for the Ocean Decade aims to achieve six critical societal outcomes (SOs) by 2030, through the pursuit of four objectives (Os). It specifically recognizes the scarcity of biological data for deep-sea biomes, and challenges the global scientific community to conduct ...
Tópico(s): Isotope Analysis in Ecology
2020 - Frontiers Media | Frontiers in Marine Science
Produção Nacional
Revisado por pares
Kerry L. Howell, Ana Hilário, A. Louise Allcock, David M. Bailey, Maria Baker, Malcolm R. Clark, Ana Colaço, Jon Copley, Erik E. Cordes, Roberto Danovaro, Awantha Dissanayake, Elva Escobar‐Briones, Patricia Esquete, Austin J. Gallagher, Andrew R. Gates, Sylvie M. Gaudron, Christopher R. German, Kristina M. Gjerde, Nicholas D. Higgs, Nadine Le Bris, Lisa A. Levin, Elisabetta Manea, Craig R. McClain, Lénaïck Menot, Nélia C. Mestre, Anna Meta×as, Rosanna Milligan, Agnes Muthumbi, Bhavani E. Narayanaswamy, Sofia P. Ramalho, Eva Ramírez-Llodra, Laura M. Robson, Alex D. Rogers, Javier Sellanes, Julia D. Sigwart, Kerry Sink, Paul V. R. Snelgrove, Paris V. Stefanoudis, Paulo Yukio Gomes Sumida, Michelle L. Taylor, Andrew R. Thurber, Rui P. Vieira, Hiromi Watanabe, Lucy C. Woodall, Joana R. Xavier,
The United Nations Decade of Ocean Science for Sustainable Development presents an exceptional opportunity to effect positive change in ocean use. We outline what is required of the deep-sea research community to achieve these ambitious objectives.
Tópico(s): Ocean Acidification Effects and Responses
2020 - Nature Portfolio | Nature Ecology & Evolution
Produção Nacional
Revisado por pares
Priscila Lamb Wink, Rafaela Ramalho Guerra, Francielle Liz Monteiro, Fabiana Caroline Zempulski Volpato, Júlia Biz Willig, Otávio von Ameln Lovison, Alexandre Prehn Zavascki, Afonso Luís Barth, Andreza Francisco Martins,
The SARS-CoV-2 P.1 lineage emerged in Amazonas (AM), North Brazil and its evolution has been dynamically reported associated with increased transmissibility and/or immune evasion. Here, we evaluated the lineages circulating in 29 cities in Rio Grande do Sul (RS), Southern Brazil between March 2020 and May 2021 and investigated the genetic events associated with the emergence of the P.1. A total of 202 oro/nasopharyngeal SARS-CoV-2 specimens from patients during routine hospital care were submitted ...
Tópico(s): Bacillus and Francisella bacterial research
2022 - American Society for Microbiology | Microbiology Spectrum
Produção Nacional
Revisado por pares
Juniana de Almeida Mota Ramalho, Mayssa’ El Husseini, Lucas Bloc, Júlia Sursis Nobre Ferro Bucher-Maluschke, Marie Rose Moro, Jonathan Lachal,
Family components can play roles both as protective factors and maintenance mechanisms of eating disorders. We aimed to investigate the role of food in the family relationships of adolescents with anorexia nervosa and bulimia in northeastern Brazil. Using photo elicitation, a visual narrative method that gives insight into the participants' perspective through photograph, we conducted semi-structured interviews with 26 people: four teenage girls with anorexia, four with bulimia, eight mothers, four ...
Tópico(s): Impact of Technology on Adolescents
2021 - Frontiers Media | Frontiers in Psychiatry
Produção Nacional
Revisado por pares
Kenya Noronha, Gilvan Ramalho Guedes, Cássio M. Turra, Mônica Viégas Andrade, Laura de Almeida Botega, Daniel Nogueira, Júlia Almeida Calazans, Lucas Resende de Carvalho, Luciana Mendes Santos Servo, Monique Félix Ferreira,
This study aims to analyze the pressure on the Brazilian health system from the additional demand created by COVID-19. The authors performed a series of simulations to estimate the demand for hospital beds (health micro-regions) as well as to ICU beds, and mechanical ventilators (health macro-regions) under different scenarios of intensity (infection rates equivalent to 0.01, 0.1, and 1 case por 100 inhabitants) and time horizons (1, 3, and 6 months). The results reveal a critical situation in the system ...
Tópico(s): Health, Nursing, Elderly Care
2020 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Maria Júlia Correia Lima Nepomuceno Araújo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Carlos Nahas, Melani Ribeiro Custódio, Rosa Maria Affonso Moysés, Elias David‐Neto,
Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown.Longitudinal follow-up of 911 ...
Tópico(s): Pancreatitis Pathology and Treatment
2018 - Elsevier BV | Surgery
Cynthia Julia Braga Batista, Renato Girade Corrêa, Livia Ramalho Evangelista, Karen Fleck, Leandro Silva, Françoise Renaud, Marco Vitória, Meg Doherty, Adele Schwartz Benzaken,
In 2017, the Ministry of Health Brazilian started using dolutegravir (DTG) 50 mg to all people living with HIV who began antiretroviral therapy (ART) or rescue regimens. Although DTG is thought to have better tolerability levels and a lower possibility of causing adverse reactions, it is necessary to continuously evaluate the safety profile of the drug in the population. Therefore, an active pharmacovigilance project for DTG was implemented. The objective of this study was to describe the Brazilian ...
Tópico(s): HIV Research and Treatment
2019 - Wolters Kluwer | Medicine
Produção Nacional
Revisado por pares
Iana Bárbara Ramalho Faria, Júlia Carvalho Ventura, Daniela Eda Silva, Rodrigo Otávio Moretti-Pires,
Pesquisa exploratória com abordagem qualitativa objetivou apreender a percepção dos profissionais sobre ofuncionamento da Estratégia Saúde da Família (ESF) no interior da Amazônia. Para a leitura dos dados, utilizou-se ahermenêutica dialética. Foram identificadas contradições entre o preconizado para a ESF e a operacionalização destemodelo de atenção: atenção às necessidades de saúde versus atendimento à demanda; vínculo profissional versusrotatividade da equipe; trabalho em equipe versus trabalho ...
Tópico(s): Youth, Drugs, and Violence
2010 - UNIVERSIDADE FEDERAL DO PARANÁ | Cogitare Enfermagem
Produção Nacional
Revisado por pares
Thaíse Lara Teixeira, Miguel Ángel Chiurillo, Noelia Lander, Cassiano Costa Rodrigues, Thiago Souza Onofre, Éden Ramalho Ferreira, Camila M. Yonamine, Júlia de Gouveia Santos, Renato A. Mortara, Cláudio Vieira da Silva, José Franco da Silveira,
P21 is an immunomodulatory protein expressed throughout the life cycle of Trypanosoma cruzi , the etiologic agent of Chagas disease. In vitro and in vivo studies have shown that P21 plays an important role in the invasion of mammalian host cells and establishment of infection in a murine model. P21 functions as a signal transducer, triggering intracellular cascades in host cells and resulting in the remodeling of the actin cytoskeleton and parasite internalization. Furthermore, in vivo studies have ...
Tópico(s): CRISPR and Genetic Engineering
2022 - Frontiers Media | Frontiers in Cellular and Infection Microbiology
Produção Nacional
Revisado por pares
Líria Maria Bettiol Lanza, Amanda de Barros Santos, Júlia Ramalho Rodrigues,
O presente artigo tematizou sobre o processo imigratório no Brasil recente e a necessidade de problematizar as políticas públicas de Seguridade Social e o território. Os imigrantes, ao se inserirem nos territórios de destino, dão significados aos mesmos, a partir de movimentos de desterritorialização e reterritorialização. Resultado de uma pesquisa qualitativa e documental, tendo como fonte documentos oficiais do Brasil e Paraná, identificamos nas políticas de Seguridade Social que há intencionalidade ...
Tópico(s): Social and Political Issues
2016 - UNIVERSIDADE FEDERAL DO ESPÍRITO SANTO | Argumentum
Produção Nacional
Revisado por pares
Leonardo Roberto da Silva, Renato Flora Vargas, Júlia Yoriko Shinzato, Sophie Derchain, Susana Ramalho, Luiz Carlos Zeferino,
To identify the biomarkers of response to neoadjuvant chemotherapy in early luminal breast cancer. A cross-sectional study that included all patients with early or locally-advanced luminal breast cancer submitted to neoadjuvant chemotherapy between 2013 and 2014. Demographic, clinic and pathologic data were retrieved from patient records. The expressions of the estrogen receptor (ER), the progesterone receptor (PR), and Ki67 were analyzed by immunohistochemistry (IHC). The status of the human epidermal ...
Tópico(s): Breast Lesions and Carcinomas
2019 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Alexandre Duarte Martins, Rafael Oliveira, João Paulo Brito, Tiago Rocha Alves Costa, Júlia Silva, Fátima Ramalho, Rita Santos‐Rocha, Nuno Pimenta,
INTRODUCTION: Body composition is one of the main variables of interest in clinical practice in cancer patients. Specific markers from bioelectrical impedance analysis, such as phase angle (PhA), have been assuming increasing relevance in this population. The aim of the present systematic review was to study and systematise the effect of exercise on PhA in cancer survivors, as compared to control conditions, namely usual care, with no exercise. The effect of exercise on PhA in the population of cancer ...
Tópico(s): Nutrition and Health in Aging
2021 - Edizioni Minerva Medica | The Journal of Sports Medicine and Physical Fitness
Juliana Balbinot Reis Girondi, Aline de Oliveira Ramalho, Maria Emilia Gaspar Ferreira Del Cistia, Algelaine Pereira Conte, Bettina Heidenreich Silva, Eluze Luz Ouriques Neta, Julia Grisard De, Milena Ronise Calegari,
Objetivos: Identificar e analisar as evidências científicas dos estudos publicados sobre o uso de Ozonioterapia no tratamento de feridas em adultos. Método: Revisão integrativa da literatura nas bases Base de Dados de Enfermagem (BDENF), Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Cumulative Index to Nursingand Allied (CINAHL), Medical Literature Analysisand Retrieval System Online (PUBMED/MEDLINE), Web of Science, EMBASE, SCOPUS, Cocharane, e nas Bibliotecas Virtual de Saúde e Scientific ...
Tópico(s): Environmental and biological studies
2021 - Brazilian Journal of Development | Brazilian Journal of Development
Ramalho Brandao Pereira Aline, Roberto Fonseca Souza Soares Claudio, Ferreira da Silva Julia, Manuela da Silva, Maria Chalfoun de Souza Sara,
Coffee beans processing generates a large volume of wastewater composed of trace elements which can be detrimental to human health. The present study aimed at evaluating the capacity of strains of Aspergillus brasiliensis and Penicillium citrinum in tolerating and removing trace elements namely: Cu, Mn and Zn from coffee wastewater. The use of fungi in the treatment of polluted wastewater has emerged as a viable alternative to conventional treatment. The fungi were isolated from polluted and unpolluted ...
Tópico(s): Constructed Wetlands for Wastewater Treatment
2014 - Academic Journals | AFRICAN JOURNAL OF BIOTECHNOLOGY
Laura Obici, Senda Ajroud‐Driss, Kon‐Ping Lin, John L. Berk, Julian D. Gillmore, Parag Kale, Haruki Koike, David Danese, Emre Aldinc, Chongshu Chen, Joshua R. Vest, David Adams, Jonas Wixner, Rolf Backlund, Björn Pilebro, Intissar Anan, Fredrik Edbom, Anna Ekman, Sandra Arvidsson, Ulrika H. Englund, Karin Söderberg, Erik Nordh, Erica Uneus, Kristin Samuelsson, A Nilzén, Rayomand Press, Mirjam Bilecen, Teresa Coelho, Marta Novais, Patrícia Rodrigues, Ana Martins da Silva, Inês Lopes Cardoso, Carla Rodrigues, Joana Ramalho, Helder Martins, Mónica G. Silva, Nádia Guimarães, Javier Martínez Pérez, Antonio Hipólito Reis, Julia R Monte, Natália Ferreira, Cristina Alves, Márcio Cardoso, Ricardo Cotrin Teixeira, Isabel Conceição, Filipa Lamas, Miguel Oliveira Santos, Catarina Falcão de Campos, Conceição de Azevedo Coutinho, José Castro, Isabel Castro, Daniela Rodrigues Silva, Susana Gonçalves, Eleonora Di Buduo, Claudia Sforzini, Roberta Mussinelli, Vittorio Rosti, Alessandro Lozza, Anna Racchi, Mario Sabatelli, Marco Luigetti, Giulia Bisogni, Ângela Romano, Valeria Guglielmino, Andrea Di Paolantonio, Daniela Bernardo, Giuseppe Vita, Anna Mazzeo, Massimo Russo, Davide Pareyson, Daniela Calabrese, Silvia Fenu, Paola Saveri, Hans L. A. Nienhuis, Geert Bokhorst, C. M. Roos, Margriet Couperus, Greetje de Jong, Anne F. Brunger, Gea Drost, Fiete Lange, Adinda Colauto, Márcia Waddington‐Cruz, Aline França de Abreu, Roberto Coury Pedrosa, Renata Gervais de Santa Rosa, Moisés Dias, Fetra Rakotondratafika, Andoni Echaniz‐Laguna, Cécile Cauquil, Céline Labeyrie, Guillemette Beaudonnet, Yasmine Boubrit, Amina Gaouar, Halima Bourenane, Shahram Attarian, El Khansa Yahia, Annie Verschueren, Aude‐Marie Grapperon, Émilien Delmont, Violaine Planté‐Bordeneuve, Laetitia Vervoitte, Samar S. Ayache, Philippe Le Corvoisier, Raphaele Arrouasse, Thierry Gendre, Laure Abou Chakra, Cécile Focseneanu, Caroline Barau, Guilhem Solé, L. Belin, Marie Helene Violleau, Fanny Duval-Bontemps, Rami Massie, Xin Dong, Francisco Muñoz-Beamud, Sandra García, Cristina Borrachero, Álvaro Gragera Martínez, Lucía Galán Dávila, Marta Palacios, Laura Martínez Vicente, Leopoldo Pérez de Isla, Carlos Casasnovas, Carles Díez‐López, Elena Muñoz Fabra, José González‐Costello, Sonia Guerrero, Sergi Yun, Yurema Martinez, Valentina Vélez-Santamaría, Velina Nedkova-Hristova, Pablo García Pavía, Ariadna González Segovia, Fernando de Frutos, Esther González-López, Fernándo Domínguez, Luis Escobar-López, Eva Cabrera-Romero, Paula Sánchez Gismera, María de la Iglesia, Fernando Martinez Valle, G Aguila, Karen Lorite, N. Raguer, Pilar Suñé, P Piera, Carlos Ortega, Carla Aguilar, Gisela Gili, Hartmut Schmidt, Christel Langenstroer, Anna Hüsing‐Kabar, Iyad Kabar, Matthias Schilling, Frauke Friebel, Phil‐Robin Tepasse, Frank Birklein, Monika Firros, Fabiola Escolano‐Lozano, Caitlin Brueckner, Vanessa Bahnam, Michelle Kaku, K. H. Vincent Lau, Janice F. Wiesman, Martha Grogan, Susanna Miller, Janell Grazzini Frantz, Diane C. Schmidt, Omar F. AbouEzzeddine, Wayne H. Miller, Grace Lin, Morie A. Gertz, Angela Dispenzieri, Thomas H. Brannagan, Raisy Fayerman, Elizabeth DuVerger, Jorge Cabrera, Mathew S. Maurer, Christina Ulane, Louis H. Weimer, Stephen H. Tsang, Jeffrey Shije, Nathan Carberry, Sai Si Thu, Dianna Quan, Brianna Blume, J. Scott Overcash, Pu He, Kia Lee, Hanh Chu, Karla Zepeda, Michael R. Waters, Thao Vuong, Derya J Coskun, Kimberly Quillin, Allison Davis, Michael Polydefkis, Jing Ye, Xiaoling Li, Mohammad Khoshnoodi, Geno Vista, Tae Hwan Chung, Michele Watt, Dan Tsottles, Ahmad Masri, Dayna Carlson, Brian Drachman, Patricia Divito, Hansie Mathelier, Margaret McCloskey Shanks, Karen Maslowski, Sami Khella, J. Pieretti, Benjamin Joslin, Emma Schmidt, Miriam Freimer, Julie Agriesti, Fábio Barroso, F Picone, Andrea Lautre, Lucas Orellana, Wenqin Du, Joost Felius, Alejandra González‐Duarte, Karla Cárdenas‐Soto, Rebecca Traub, Manisha Chopra, Chi‐Chao Chao, Chia-Hua Hsu, Li‐Kai Tsai, Ming‐Jen Lee, Jen-Jen Su, Sung‐Tsang Hsieh, Hsueh‐Wen Hsueh, Hsi-Chieh Chou, Byoung‐Joon Kim, Hyesun Kang, Ju‐Hong Min, Eun‐Seok Jeon, Yeon Hak Chung, Jae Hong Park, Jeeyoung Oh, Hyeon Joo Jeong, Ivailo Tournev, Sashka Zhelyazkova, Yohei Misumi, Yumiko Sakamoto, Nami Hashimoto, Yoshimi Misumi, Aya Takahashi, Mitsuharu Ueda, Teruaki Masuda, Mitsuharu Ueda, Masahisa Katsuno, Kazuki Tajima, Momoko Sumi, Fujiko Hasegawa, Takahiro Okumura, Masahiro Iijima, Yuki Fukami, Daisuke Ito, Yoshiyuki Kishimoto, Tomoyuki Kazuta, Katsuhiko Kato, Naohiro Mouri, Soma Furukawa, Ryoji Nishi, Yoshiki Sekijima, Keiko Ito, Naga-aki Kato, Dai Kishida, Hideki Mochizuki, Kaori Okada, Kurumi Ohashi, Kensuke Ikenaka, Masayuki Nakamori, Makoto Kinoshita, Bella Ruth R. Mapalo, Steven Law, Liza Chacko, Helen J. Lachmann, Oliver Cohen, Yousuf Razvi, Sindhu Varughese, Ana Martinez‐Naharro, Richard W. Orrell, Marianna Fontana, Lisa Rannigan, Sarah Louth, Eleni Zamba‐Papanicolaou, Demetra Charalamnibous, Rana Abu Manneh, Kleopas A. Kleopa, Theodoros Christodoulides, Savvas Frangos,
Hereditary transthyretin (ATTRv; v for variant) amyloidosis, also known as hATTR amyloidosis, is a progressive and fatal disease associated with rapid deterioration of physical function and patients' quality of life (QOL). Vutrisiran, a subcutaneously administered RNA interference (RNAi) therapeutic that reduces hepatic production of transthyretin, was assessed in patients with ATTRv amyloidosis with polyneuropathy in the pivotal HELIOS-A study.The phase 3 open-label HELIOS-A study investigated the ...
Adis, Springer Healthcare
David Adams, Michael Polydefkis, Alejandra González‐Duarte, Jonas Wixner, Arnt V. Kristen, Hartmut Schmidt, John L. Berk, Inés Asunción Losada López, Angela Dispenzieri, Dianna Quan, Isabel Conceição, Michel Slama, Julian D. Gillmore, Theodoros Kyriakides, Senda Ajroud‐Driss, Márcia Waddington‐Cruz, Michelle M. Mezei, Violaine Planté‐Bordeneuve, Shahram Attarian, Elizabeth A. Mauricio, Thomas H. Brannagan, Mitsuharu Ueda, Emre Aldinc, Jing Jing Wang, Matthew T. White, Joshua R. Vest, Erhan Berber, Marianne T. Sweetser, Teresa Coelho, Giuseppe Vita, Vincenzo Rizzo, Massimo Russo, Anna Mazzeo, Luca Gentile, John L. Berk, Caitlin Brueckner, Victoria Lazzari, Janice F. Wiesman, Douglas DeLong, Jennifer Victory, James A. R. Dalton, John J. May, Catherine Gilmore, Shahram Attarian, Saran Diallo, Émilien Delmont, Jean Pouget, Annie Verschueren, Aude‐Marie Grapperon, Emmanuelle Salort‐Campana, Isabel Conceição, Ana Tarina Alvarez Lopes, Filipa Lamas, Carlos Marques‐Neves, José Castro, Pedro Pereira, Isabel Castro, Ana Franco, Miguel Oliveira Santos, Conceição de Azevedo Coutinho, Catarina Falcão de Campos, Teresa Coelho, Antonio Hipólito Reis, Nuno Correia, Javier Martínez Pérez, Ana Martins da Silva, Cristina Alves, Márcio Cardoso, Kátia Valdrez, Julia R Monte, Bernardete Pessoa, Nádia Guimarães, Mónica Freitas, Joana Ramalho, Natália Ferreira, Daisuke Kuzume, Céline Tard, Nawal Waucquier, Isabelle Rougeaux, Sylvie Brice, Emmanuelle Kasprzyk, Elise Elrezzi, Sayah Meguig, É. Hachulla, Clément Gauvain, Maria-Claire Migaud-Chervy, Dominique Deplanque, Elsa Jozefowicz, Loïc Lebellec, David B. Adams, Line Balaya-Gouraya, Nathalie Jehan Lacour, Halima Bournane, Nathalie Martin, Mongia Elabed, Niamey Sacko, Yasmine Boubrit, Amina Gaouar, Fetra Rakotondratafika, Marie Théaudin-Saliou, Cécile Cauquil-Michon, Céline Labeyrie, Adeline Not, Abdallah Al‐Salameh, Anne-Lise Lecoq, Maeva Stephant, Andoni Echaniz‐Laguna, Laurent Becquemont, Guillemette Beaudonnet, Vincent Algalarrondo, Ludivine Eliahou, Michel Slama, Antoine Rousseau, Aïssatou Signaté, Emeline Berthelot, Jocelyn Inamo, Violaine Planté‐Bordeneuve, Laetitia Vervoitte, Cécile Focseneanu, Thierry Gendre, Raphaele Arrouasse, Samar S. Ayache, Laura Ernande, Philippe Le Corvoisier, Hayet Salhi, Ariane Choumert, Vincent Ehinger, J. Pérez Ruiz, Cyril Charlin, Thomas Megelin, Thomas H. Brannagan, Raisy Fayerman, Arreum Kim, Allan Paras, Leidy González, Steven Tsang, Fernanda Wajnsztajn, Jeffrey Shije, Christina Ulane, Inna Kleyman, Louis H. Weimer, Comana Cioroiu, Sakis Lambrianides, Rana Abu-Manneh, Eleni Zamba‐Papanicolaou, Petros Agathangelou, Eleni Leonidou, Satoshi Tada, Akemi Fujita, Masahiro Nagai, Rina Ando, Yuko Hosokawa, Yuki Yamanishi, J. Scott Overcash, Elena Giardino, Leslie Boyer, Lien Dang, An K. Le, Tyler Nguyen, Lien Giang, P Sellers, Leyla Tran, Nghi Truong, Maita Vinas, Nicole Hrkman, S. David Miller, David Nguyen, Ashley Smith, Helen Pu, S. Li, Thao Vuong, Holly Dioso, Sinikka Green, Kia Lee, Hanh Chu, Michael R. Waters, Derya J Coskun, Karla A Zepeda, William O’Riordan, Laura Obici, Andrea Cortese, Alessandro Lozza, Giampaolo Merlini, Vittorio Rosti, Mario Sabatelli, Giulia Bisogni, Daniela Bernardo, Marco Luigetti, Andrea Di Paolantonio, Valeria Guglielmino, Giulia Bisogni, Ângela Romano, Hans L. A. Nienhuis, Janita Bulthuis-Kuiper, Arnt V. Kristen, Olga Gerk, Hannah Ulbricht, Lenka A. Taylor, Eva Meyle, Natalia Kleinschmidt, David Meyrath, Simone Noe-Schwenn, Ulrike Meng, Ralf Bauer, Fabian aus dem Siepen, Selina Hein, Tetsuya Takahashi, T Oshita, Yoko Koujin, Shuichiro Neshige, Tomohisa Nezu, Akiko Segawa, Hiroki Ueno, Hiroyuki Morino, Josep M. Campistol, Lida María Rodas Marín, Josep Miquel Blasco Pelicano, Lucía Galán Dávila, Marta Palacios, Vanesa Pytel Cordoba, A. Guerrero Sola, Alejandro Horga, J. García–Sánchez, Leopoldo Pérez de Isla, Wilson Marques, Mariana Moscardini, Debora C. Litcanov, Ana Flavia Viera Lima, Leonardo Rodrigues, Barbara Marques Coutinho, Carolina Lavigne Moreira, Vanessa Daccach Marques, Francisco Muñoz Beamud, Álvaro Gragera Martínez, Cristina Borrachero, Inés Asunción Losada López, Eugenia Cisneros‐Barroso, Adrián Rodríguez, Mónica Sanz, E Oliver, Juan González Moreno, J. Michael Martinez, Cristina Descals, Mercedes Usón, Francisco Jose Vega, Antoni Figuerola, Carles Montalá, Márcia Waddington‐Cruz, Moises Dias da Silva, Renata Gervais de Santa Rosa, Luiz Felipe Pinto, Marcus Vinícius Pinto, Amanda Cardoso Berensztejn, Fábio Barroso, Andrea Lautre, Lucas Orellana, Maria Alejandra González-Duarte Briseño, Karla Cárdenas‐Soto, Brenda Poled Jiménez López, Sandra Lorena Pérez-Castañeda, Carlos Cantú‐Brito, David Rivera de la Parra, Jose Pablo Hernandez Reyes, Maria del Mar Saniger Alba, Elia Criollo Mora, Yeşim Parman, Kus Jülide Rezzan, Erdi Şahin, Nail Güven Serbest, Hacer Durmuş, Arman Çakar, Nuriye Ilknur Tugal Tutkun, Saçit Karamürsel, Ali Elitok, Nermin G Sirin Inan, Emre Altinkurt, Michael Polydefkis, Jing Ye, Adriane C Allen, Vinay Chaudhry, R. J. Jarrett, Neil M. Bressler, Kathleen Burks, Qingfeng Liu, Mohammad Khoshnoodi, Daniel P. Judge, Geno Vista, Syed Mahmood Shah, Hirotoshi Hamaguchi, Junko Oda, Emi Fukase, I Taniguchi, Tetsuya Oda, Hironobu Endo, Masahiro Shimomura, Kimitaka Katanazaka,
Background Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Methods This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries ...
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