Dajana Reuter, Tim Sparwasser, Thomas Hünig, Jürgen Schneider‐Schaulies,
We earlier established a model of a persistent viral CNS infection using two week old immunologically normal (genetically unmodified) mice and recombinant measles virus (MV). Using this model infection we investigated the role of regulatory T cells (Tregs) as regulators of the immune response in the brain, and assessed whether the persistent CNS infection can be modulated by manipulation of Tregs in the periphery. CD4+ CD25+ Foxp3+ Tregs were expanded or depleted during the persistent phase of the ...
Tópico(s): Immunotherapy and Immune Responses
2012 - Public Library of Science | PLoS ONE
Olaf Groß, Andreas Gewies, Katrin Finger, Martin Jörg Schäfer, Tim Sparwasser, Christian Peschel, Irmgard Förster, Jürgen Ruland,
Tópico(s): Antimicrobial Peptides and Activities
2006 - Nature Portfolio | Nature
Franz Porzsolt, D. Messerer, Richard E. Hautmann, A. Gottwald, H. Sparwasser, K. Stockamp, Walter E. Aulitzky, Jürgen Moormann, Kurt R. Schumacher, H. Rasche, U. Papendick, W. Schreml,
Tópico(s): Cancer Genomics and Diagnostics
1988 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Stefanie Klemm, Jan Gutermuth, Lothar Hültner, Tim Sparwasser, Heidrun Behrendt, Christian Peschel, Tak W. Mak, Thilo Jakob, Jürgen Ruland,
Mast cells are pivotal effector cells in IgE-mediated allergic inflammatory diseases. Central for mast cell activation are signals from the IgE receptor FcεRI, which induce cell degranulation with the release of preformed mediators and de novo synthesis of proinflammatory leukotrienes and cytokines. How these individual mast cell responses are differentially controlled is still unresolved. We identify B cell lymphoma 10 (Bcl10) and mucosa-associated lymphoid tissue 1 (Malt1) as novel key regulators ...
Tópico(s): Urticaria and Related Conditions
2006 - Rockefeller University Press | The Journal of Experimental Medicine
Konstanze Pechloff, Julian Walter Holch, Uta Ferch, Marc Schweneker, Kristina Brunner, Markus Kremer, Tim Sparwasser, Leticia Quintanilla‐Martínez, Ursula Zimber‐Strobl, Berthold Streubel, Andreas Gewies, Christian Peschel, Jürgen Ruland,
Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small animal models for the disease are lacking. Recently, the chromosomal translocation t(5;9)(q33;q22) generating the interleukin-2 (IL-2)–inducible T cell kinase (ITK)–spleen tyrosine kinase (SYK) fusion tyrosine kinase was identified as a recurrent event in PTCL. We show that ITK-SYK associates constitutively with lipid rafts in T cells and triggers ...
Tópico(s): T-cell and Retrovirus Studies
2010 - Rockefeller University Press | The Journal of Experimental Medicine
Martin H. Schaefer, Norbert Reiling, Cornelia Fessler, Johannes Stephani, Ichiro Taniuchi, Farahnaz Hatam, Ali Önder Yildirim, Heinz Fehrenbach, Kerstin Walter, Jürgen Ruland, Hermann Wagner, Stefan Ehlers, Tim Sparwasser,
Dendritic cell (DC)-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN: CD209) is a C-type lectin that binds ICAM-2,3 and various pathogens such as HIV, helicobacter, and mycobacteria. It has been suggested that Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, interacts with DC-SIGN to evade the immune system. To directly analyze the role of human DC-SIGN during mycobacterial infection, we generated conventional transgenic (tg) mice (termed "hSIGN") using ...
Tópico(s): Immune Cell Function and Interaction
2008 - American Association of Immunologists | The Journal of Immunology
... television, developed dual loyalties. Fans simultaneously rejoiced in Jürgen Sparwasser’s decisive goal in the 1974 World Cup ...
Tópico(s): German History and Society
2017 - German Studies Association | German Studies Review
Branka Popović, Mijo Golemac, Jürgen Podlech, Jelena Železnjak, Lidija Bilić-Zulle, Miodrag L. Lukić, Luka Čičin‐Šain, Matthias J. Reddehase, Tim Sparwasser, Astrid Krmpotić, Stipan Jonjić,
Regulatory T (Treg) cells dampen an exaggerated immune response to viral infections in order to avoid immunopathology. Cytomegaloviruses (CMVs) are herpesviruses usually causing asymptomatic infection in immunocompetent hosts and induce strong cellular immunity which provides protection against CMV disease. It remains unclear how these persistent viruses manage to avoid induction of immunopathology not only during the acute infection but also during life-long persistence and virus reactivation. This ...
Tópico(s): Cytomegalovirus and herpesvirus research
2017 - Public Library of Science | PLoS Pathogens
Konstanze Pechloff, Julian Walter Holch, Uta Ferch, Marc Schweneker, Kristina Brunner, Markus Kremer, Tim Sparwasser, Leticia Quintanilla‐Martínez, Ursula Zimber‐Strobl, Berthold Streubel, Andreas Gewies, Christian Peschel, Jürgen Ruland,
Tópico(s): Cutaneous lymphoproliferative disorders research
2010 - Rockefeller University Press | The Journal of Cell Biology
Victor Palit, H.N. Ashurst, C.S. Biyani, Y. Elmasray, Rajesh Puri, Tejash Shah, Ferıha Ercan, Şule Çetınel, Nuray Erin, Hakan Aydın, Canan Hürdağ, Terry Parker, Kate Parker, Terry M. Mayhew, Драга Тончева, Boriana M. Zaharieva, Mahesh C. Goel, D.W. Williams, Hughes Evans, J.G. Roberts, Anne Herbst, Hans Schmelz, C. Sparwasser, Ildikò Riedler, Eckart Gronau, Jürgen Pannek, Matthias Böhme, Theodor Senge, Frederico Teixeira Brandt, Carla Daisy Costa Albuquerque, Carlos Teixeira Brandt, Felipe Rinald Barbosa Lorenzato, Cláudio Ribeiro Leal, Carolina Duarte Barbosa, Leonor Viana Nóbrega, M. Gürkaynak, Fadıl Akyol, Faruk Zorlu, Serap Akyürek, Ferah Yıldız, İ. Lale Atahan, P. San Miguel, Gonzalo Fernández, Felipe Sacristán, C. Álvarez, J.A. Ortiz-Rey, Iker Antón, E Zungri, A. De la Fuente, J. Alfred Witjes, J.L.J. Vriesema, K. Brinkman, G. Bootsma, J. Barentsz, Pierfrancesco Veroux, Massimiliano Veroux, Carmelo Puliatti, Mariachiara Valvo, M. Macarone, D. Cappello, Axel Hegele, P. Olbert, Marion Roeßler, A. Heidenreich, Remigius Hofmann, Harald Trummer, Peter Hebel, Gerhart Hubmer, Marco De Sio, Riccardo Autorino, Giuseppe Di Lorenzo, Rocco Damiano, Luca Cosentino, Sabino De Placido, Massimo D’Armiento, Rajeev Kumar, Narmada P. Gupta, Fernando Tadeu Andrade‐Rocha, Mut Şafak, Çağatay Göğüş, Tarkan Soygür, Tomohiro Kuwahara, Yoshihiro Wada, Wataru Takahashi, Masaki Yoshida, Hitoshi Iwashita, Hiroaki Kikukawa, Juro Nakanishi, Shoichi Ueda, Antonella Coli, Giulio Bigotti, C Dell'Isola, Federica Castri, F Rulli, Guido Massi, Mustafa Özgür Tan, M. Cemil Uygur, Yusuf Diker, Demokan Erol,
2003 - Karger Publishers | Urologia Internationalis
Victor Palit, H.N. Ashurst, C.S. Biyani, Y. Elmasray, Rajesh Puri, Tejash Shah, Ferıha Ercan, Şule Çetınel, Nuray Erin, Hakan Aydın, Canan Hürdağ, Terry Parker, Kate Parker, Terry M. Mayhew, Драга Тончева, Boriana M. Zaharieva, Mahesh C. Goel, D.W. Williams, Hughes Evans, J.G. Roberts, Anne Herbst, Hans Schmelz, C. Sparwasser, Ildikò Riedler, Eckart Gronau, Jürgen Pannek, Matthias Böhme, Theodor Senge, Frederico Teixeira Brandt, Carla Daisy Costa Albuquerque, Carlos Teixeira Brandt, Felipe Rinald Barbosa Lorenzato, Cláudio Ribeiro Leal, Carolina Duarte Barbosa, Leonor Viana Nóbrega, M. Gürkaynak, Fadıl Akyol, Faruk Zorlu, Serap Akyürek, Ferah Yıldız, İ. Lale Atahan, P. San Miguel, Gonzalo Fernández, Felipe Sacristán, Carlos A. Álvarez, J.A. Ortiz-Rey, Iker Antón, E Zungri, A. De la Fuente, J. Alfred Witjes, J.L.J. Vriesema, K. Brinkman, G. Bootsma, J. Barentsz, Pierfrancesco Veroux, Massimiliano Veroux, Carmelo Puliatti, Mariachiara Valvo, M. Macarone, D. Cappello, Axel Hegele, P. Olbert, Marion Roeßler, A. Heidenreich, R. Hofmann, Harald Trummer, Peter Hebel, Gerhart Hubmer, Marco De Sio, Riccardo Autorino, Giuseppe Di Lorenzo, Rocco Damiano, Luca Cosentino, Sabino De Placido, Massimo D’Armiento, Rajeev Kumar, Narmada P. Gupta, Fernando Tadeu Andrade‐Rocha, Mut Şafak, Çağatay Göğüş, Tarkan Soygür, Tomohiro Kuwahara, Yoshihiro Wada, Wataru Takahashi, Masaki Yoshida, Hitoshi Iwashita, Hiroaki Kikukawa, Juro Nakanishi, Shoichi Ueda, Antonella Coli, Giulio Bigotti, C Dell'Isola, Federica Castri, F Rulli, Guido Massi, Mustafa Özgür Tan, M. Cemil Uygur, Yusuf Diker, Demokan Erol,
2003 - Karger Publishers | Urologia Internationalis
Victor Palit, H.N. Ashurst, C.S. Biyani, Y. Elmasray, Rajesh Puri, Tejash Shah, Ferıha Ercan, Şule Çetınel, Nuray Erin, Hakan Aydın, Canan Hürdağ, Terry Parker, Kate Parker, Terry M. Mayhew, Драга Тончева, Boriana M. Zaharieva, Mahesh C. Goel, D.W. Williams, Hughes Evans, J.G. Roberts, Anne Herbst, Hans Schmelz, C. Sparwasser, Ildikò Riedler, Eckart Gronau, Jürgen Pannek, Matthias Böhme, Theodor Senge, Frederico Teixeira Brandt, Carla Daisy Costa Albuquerque, Carlos Teixeira Brandt, Felipe Rinald Barbosa Lorenzato, Cláudio Ribeiro Leal, Carolina Duarte Barbosa, Leonor Viana Nóbrega, M. Gürkaynak, Fadıl Akyol, Faruk Zorlu, Serap Akyürek, Ferah Yıldız, İ. Lale Atahan, P. San Miguel, Gonzalo Fernández, Felipe Sacristán, C. Álvarez, J.A. Ortiz-Rey, Iker Antón, E Zungri, A. De la Fuente, J. Alfred Witjes, J.L.J. Vriesema, K. Brinkman, G. Bootsma, J. Barentsz, Pierfrancesco Veroux, Massimiliano Veroux, Carmelo Puliatti, Mariachiara Valvo, M. Macarone, D. Cappello, Axel Hegele, P. Olbert, Marion Roeßler, A. Heidenreich, Remigius Hofmann, Harald Trummer, Peter Hebel, Gerhart Hubmer, Marco De Sio, Riccardo Autorino, Giuseppe Di Lorenzo, Rocco Damiano, Luca Cosentino, Sabino De Placido, Massimo D’Armiento, Rajeev Kumar, Narmada P. Gupta, Fernando Tadeu Andrade‐Rocha, Mut Şafak, Çağatay Göğüş, Tarkan Soygür, Tomohiro Kuwahara, Yoshihiro Wada, Wataru Takahashi, Masaki Yoshida, Hitoshi Iwashita, Hiroaki Kikukawa, Juro Nakanishi, Shoichi Ueda, Antonella Coli, Giulio Bigotti, C Dell'Isola, Federica Castri, F Rulli, Guido Massi, Mustafa Özgür Tan, M. Cemil Uygur, Yusuf Diker, Demokan Erol,
2003 - Karger Publishers | Urologia Internationalis
Stefanie Klemm, Jan Gutermuth, Lothar Hültner, Tim Sparwasser, Heidrun Behrendt, Christian Peschel, Tak W. Mak, Thilo Jakob, Jürgen Ruland,
Mast cells are pivotal effector cells in IgE-mediated allergic infl ammatory diseases.Central for mast cell activation are signals from the IgE receptor FcRI, which induce cell degranulation with the release of preformed mediators and de novo synthesis of proinfl ammatory leukotrienes and cytokines.How these individual mast cell responses are differentially controlled is still unresolved.We identify B cell lymphoma 10 (Bcl10) and mucosaassociated lymphoid tissue 1 (Malt1) as novel key regulators of ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2006 - Rockefeller University Press | The Journal of Cell Biology
Stefanie Klemm, Jan Gutermuth, L. Hueltner, Tim Sparwasser, Heidrun Behrendt, Christian Peschel, T W Mak, Thomas Jacob, Jürgen Ruland,
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2006 - Elsevier BV | Journal of Investigative Dermatology
C. Mache, Ch. Urban, H. Sauer, G. Brandesky, H. Meßner, H. Grienberger, H. Becker, I. Slave, Ch. Hauer, B. Pakisch, R. Oberbauer, M. Mokry, F. Ebner, R. Kleinert, D. Schiller, H. Kasparu, G. Schneider, W. Sega, D. Lutz, R. M. Mader, G. G. Steger, A. E. Sieder, L. Ovissi, E. Roth, G. Hamilton, R. Jakesz, H. Rainer, T. Schenk, G. Kornek, F. Schulz, D. Depisch, H. Rosen, Ch. Sebesta, W. Scheithauer, G. J. Locker, J. Czernin, K. Derfler, M. Gnant, R. Schiessel, E. Petru, H. Pickel, M. Heydarfadai, M. Lahousen, J. Haas, P. Sagaster, J. Flamm, H. Umek, R. Essl, G. Teich, M. Micksche, H. Ludwig, P. F. Ambros, V. Lestou, S. Strehl, G. Mann, H. Gadner, B. Eibl, E. Greiter, K. Grünewald, G. Gastl, J. Thaler, W. Aulitzky, T. Lion, T. Henn, A. Gaiger, J. Hofmann, A. Wolf, M. Spitaler, Christof Ludescher, H. Grunicke, G. Mitterbauer, E. Stangl, K. Geissler, U. Jäger, K. Lechner, Christine Mannhalter, Oskar A. Haas, Anthi Tirita, P. Kahls, O. Haas, W. Hinterberger, W. Linkesch, Michael Pober, Ingrid Fae, Alexander Kyrle, Andrea Neumeister, Simon Panzer, D. Kandioler, A. End, R. Grill, H. Karlic, T. Inhauser, A. Chott, H. Pirc-Danoewinata, W. Klepetko, R. Heinz, G. Hopfinger-Limberger, Elke Köller, B. Schneider, E. Pittermann, C. Lorber, S. Eichinger, E. Neumann, J. Weidinger, H. Gisslinger, P. Bedford, D. Jones, J. Cawley, D. Catovsky, P. Bevan, R. Scherrer, P. Bettelheim, P. Knöbl, P. A. Kyrie, K. Lazcíka, I. Schwarzinger, C. Sillaber, H. Watzke, M. Dávid, H. Losonczy, A. Matolcsy, M. Papp, F. C. Prischl, J. D. Schwarzmeier, Andreas Zoubek, Jochen Harbott, Jutta Ritterbach, Jörg Ritter, Ch. Sillaber, Hilal Tan Ağış, E. Spanblöchl, W. R. Sperr, P. Valent, K. Czerwenka, I. Virgolini, Suhui li, M. Müller, M. Wrann, S. Gaggl, B. Fasching, M. Herold, D. Geissler, D. Nachbaur, Ch. Huber, H. Schwaighofer, M. Pichl, D. Hiddemann Niederwieser, B. Gilly, H. Weissel, Ch. Lorber, J. Schwarzmeier, C. Gasché, W. Reinisch, M. F. Hilgarth, F. Keil, C. Thomssen, H. J. Kolb, E. Holler, W. Wilmanns, H. Tilg, A. Gächter, E. R. Panzer-Grümayer, O. Majdic, J. H. Kersey, A. L. Petzer, R. Bilgeri, U. Zilian, F. H. Geisen, M. Haun, G. Konwalinka, D. Fuchs, R. Zangerle, E. Artner-Dworzak, Günter Weiß, P. Fritsch, G. P. Tilz, M. P. Dierich, H. Wachter, J. Schüller, M. J. Czejka, W. Jäger, B. Meyer, C. Weiss, G. Schernthaner, Ch. Marosi, E. Onderka, B. Schlögl, T. Maca, R. Hanak, Ch. Mannhalter, B. Brenner, R. Mayer, A. Langmann, G. Langmann, J. Slave, E. Poier, G. Stücklschweiger, A. Hackl, A. Fritz, I. Pabinger, A. Willfort, E. Groiss, M. Bernhart, R. Waldner, O. Krieger, H. Nowotny, H. Strobl, G. Michlmayr, M. Mistrik, L. lstvan, S. Kapiotis, K. Laczika, W. Speiser, A. Granena, J. Hermans, F. Zwaan, A. Gratwohl, Boris Labar, M. Mrsić, D. Nemet, V. Bogdanić, I. Radman, Silva Zupančić-Šalek, Jasna Kovačević-Metelko, I. Aurer, C. Forstinger, C. Scholten, P. Kier, P. Kalhs, W. Schwinger, I. Slavc, H. Lackner, W. Nussbaumer, E. Fritsch, M. Fink, O. Zechner, I. Kührer, V. Kletter, S. Frey, C. Leitgeb, E. Fritz, H. Silly, R. Brezinschek, I. Kuss, H. Stöger, M. Schmid, H. Samonigg, M. Wilders-Truschnig, F. Schmidt, T. Bauernhofer, A. K. Kasparek, F. Ploner, H. Stoeger, R. Moser, W. Leikauf, F. Klemm, F. Pfeffel, H. Niessner, H. Poschauko, E. Pojer, G. J. Locker, J. Braun, M. F. X. Gnant, I. Michl, R. Pirker, A. Liebhard, C. Zielinski, C. Dittrich, S. I. Bernát, E. Pongrácz, J. Kastner, M. Raderer, Z. Jorbenyi, A. Yilmaz, L. Suardet, H. Lahm, N. Odartchenko, Gy. Varga, L. A. Sréter, D. Oberberg, W. E. Berdel, Rizki Budiman, C. Brand, S. Berkessy, G. Radványi, Zs. Pauker, Zs. Nagy, Å. Karádi, S. Serti, R. Hainz, P. Kirchweger, C. Prager, Jose A. Vazquez de Prada, S. Neifer, U. Bienzle, P. Kremsner,
Springer Science+Business Media