Basar Cenik, Chantelle F. Sephton, Bercin Kutluk Cenik, Joachim Herz, Gang Yu,
... Dearborn J.T. Wozniak D.F. Cairns N.J. Core features of frontotemporal dementia recapitulated in progranulin knock- ... Dearborn J.T. Wozniak D.F. Cairns N.J. Core features of frontotemporal dementia recapitulated in progranulin knock- ... Dearborn J.T. Wozniak D.F. Cairns N.J. Core features of frontotemporal dementia recapitulated in progranulin knock- ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2012 - Elsevier BV | Journal of Biological Chemistry
Ana Cámara, Yaroslau Compta, Alexandra Pérez‐Soriano, Núria Montagut, M. Baixauli, L. Maragall, E. Ludeña, Juan Carlos Lopez de los Reyes, L. Peri-Cusí, Noemí Fernández, S. Villote, Maribel Ahuir, Anna Grau, Núria Caballol, Maríateresa Buongiorno, Claustre Pont‐Sunyer, Víctor Puente, Darly Milena Giraldo, Oriol de Fábregues, Alícia Garrido, Judith Navarro‐Otano, Cèlia Painous, Almudena Sánchez‐Gómez, Esteban Muñoz, I. Zaro, Donina Obiang, Francesc Valldeoriola, María Lombraña, María‐José Martí,
... G. Paz González J.M. Feal Painceiras M.J. Cores Bartolomé C. Valdés Aymerich L. García Sancho C. ... G. Paz González J.M. Feal Painceiras M.J. Cores Bartolomé C. Valdés Aymerich L. García Sancho C. ... G. Paz González J.M. Feal Painceiras M.J. Cores Bartolomé C. Valdés Aymerich L. García Sancho C. ...
Tópico(s): Cerebral Palsy and Movement Disorders
2021 - Elsevier BV | Parkinsonism & Related Disorders
Robert J. Core, John A. Henning, Jorge L. Gardea‐Torresdey,
... Spp. as Potential Signals for Alfalfa Weevil ResponseRobert J. Core, John A. Henning, and Jorge Gardea-TorresdeyCite this: ...
Tópico(s): Insect Utilization and Effects
1994 - American Chemical Society | Journal of Agricultural and Food Chemistry
Amy C. Seila, Leighton J. Core, John T. Lis, Phillip A. Sharp,
Divergent transcription is common of many promoters in organisms as diverse as mammals and yeast. Many independent experiments indicate that RNA polymerase II is frequently initiated but paused in the sense direction downstream from the promoter. Similarly a second peak of transcriptionally-engaged polymerase is paused in the anti-sense direction upstream of the promoter. Chromatin modifications that are associated with active promoters reside in nucleosomes immediately flanking this pair of paused ...
Tópico(s): RNA Research and Splicing
2009 - Taylor & Francis | Cell Cycle
Leighton J. Core, John T. Lis,
Enhancers act over many kilobase pairs to activate target promoters, but their activity is constrained by insulator elements that prevent indiscriminate activation of nearby genes. In the July 1, 2009, issue of Genes & Development , Chopra and colleagues (pp. 1505–1509) report that promoters containing a stalled Pol II are activated by enhancers, but these promoters also serve as insulators that block enhancers from reaching more distal genes. This new class of insulators provide critical clues to regulatory ...
Tópico(s): Cancer-related gene regulation
2009 - Cold Spring Harbor Laboratory Press | Genes & Development
Rob Duffield, Aaron J. Coutts, John Quinn,
Duffield, R, Coutts, AJ, and Quinn, J. Core temperature responses and match running performance during intermittent-sprint exercise competition in warm conditions. J Strength Cond Res 23(4): 1238-1244, ...
Tópico(s): Exercise and Physiological Responses
2009 - Lippincott Williams & Wilkins | The Journal of Strength and Conditioning Research
Shu Ishikawa, Leighton J. Core, Marta Perego,
The RapA and RapB proteins are aspartyl phosphate phosphatases that specifically dephosphorylate the Spo0F∼P intermediate response regulator of the phosphorelay signal transduction system for sporulation initiation in Bacillus subtilis. The ∼48-kDa His-tag derivative proteins were purified by metal affinity chromatography, and their molecular and biochemical characteristics were studied. RapA and RapB were found to be dimers in solution. Enzymatic activity was strongly dependent upon maintaining ...
Tópico(s): Fungal and yeast genetics research
2002 - Elsevier BV | Journal of Biological Chemistry
Russell W. Chesney, Aaron Friedman, William P. Kanto, Bonita Stanton, Terrence L. Stull,
... of “core competencies” for all health professionals.12McInerney J Core competencies in genetics essential for all healthcare professionals. ...
Tópico(s): RNA modifications and cancer
2002 - Elsevier BV | The Journal of Pediatrics
Leighton J. Core, Marta Perego,
Summary The Bacillus subtilis Rap family of proteins are characterized by protein–protein interaction modules containing the so‐called tetratricopeptide repeats (TPRs). The six TPR motifs of RapC mediate its interaction with the pentapeptide inhibitor PhrC (ERGMT) or with its target protein ComA, a phosphorylation‐dependent response regulator transcription factor for genetic competence. Our results show that RapC interaction with ComA inhibits the response regulator's ability to bind its target DNA ...
Tópico(s): Bacillus and Francisella bacterial research
2003 - Wiley | Molecular Microbiology
John A. Henning, Robert J. Core, Jorge L. Gardea‐Torresdey,
Analysis of plant volatile compounds typically requires large amounts of plant tissue, thus preventing sampling from specific morphological regions of individual plants. We used supercritical fluid extraction (SFE), with CO 2 as the solvent, to extract plant volatiles from 1.5 g of fresh alfalfa germplasm tissue ( Medicago sativa L. and M. glandulosa David). More than 100 volatile and semi‐volatile compounds were detected by gas chromatography‐mass spectrometry (GS‐MS); most of the these (>80) were in ...
Tópico(s): Essential Oils and Antimicrobial Activity
1994 - Wiley | Crop Science
Miltiadis Kininis, Gary D. Isaacs, Leighton J. Core, Nasun Hah, W. Lee Kraus,
Under classical models for signal-dependent transcription in eukaryotes, DNA-binding activator proteins regulate the recruitment of RNA polymerase II (Pol II) to a set of target promoters. However, recent studies, as well as our results herein, show that Pol II is widely distributed (i.e., "preloaded") at the promoters of many genes prior to specific signaling events. How Pol II recruitment and Pol II preloading fit within a unified model of gene regulation is unclear. In addition, the mechanisms through ...
Tópico(s): Genomics and Chromatin Dynamics
2008 - Taylor & Francis | Molecular and Cellular Biology
Leighton J. Core, John T. Lis,
Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.
Tópico(s): RNA modifications and cancer
2008 - American Association for the Advancement of Science | Science
B WOOD, Sune G. Nielsen, Mark Rehkämper, A HALLIDAY,
... likely conditions (initially reducing [Wade, J., Wood, B.J., Core formation and the oxidation state of the Earth, ...
Tópico(s): Radioactive element chemistry and processing
2008 - Elsevier BV | Earth and Planetary Science Letters
Leighton J. Core, Joshua J. Waterfall, John T. Lis,
RNA polymerases are highly regulated molecular machines. We present a method (global run-on sequencing, GRO-seq) that maps the position, amount, and orientation of transcriptionally engaged RNA polymerases genome-wide. In this method, nuclear run-on RNA molecules are subjected to large-scale parallel sequencing and mapped to the genome. We show that peaks of promoter-proximal polymerase reside on approximately 30% of human genes, transcription extends beyond pre-messenger RNA 3' cleavage, and antisense ...
Tópico(s): RNA and protein synthesis mechanisms
2008 - American Association for the Advancement of Science | Science
Yoshio Matsui, Katsumi Eguchi, Michael F. O’Rourke, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario,
Objective Excess aldosterone has a detrimental effect on large artery stiffness. We aimed to investigate the association of the change in plasma aldosterone concentration (PAC) by antihypertensive medication with the change in aortic pulse wave velocity (aPWV). Methods We conducted a prospective, randomized, open-label, blinded end-point study in 207 hypertensive patients. Patients received olmesartan monotherapy for 12 weeks, followed by add-on use of hydrochlorothiazide (HCTZ; n = 104) or azelnidipine ( ...
Tópico(s): Hormonal Regulation and Hypertension
2010 - Elsevier BV | Atherosclerosis
Michael J. Kane, Tammy J. Core, R. R. Hunt,
Psychological change is difficult to assess, in part because self-reported beliefs and attitudes may be biased or distorted. The present study probed belief change, in an educational context, by using the hindsight bias to counter another bias that generally plagues assessment of subjective change. Although research has indicated that skepticism courses reduce paranormal beliefs, those findings may reflect demand characteristics (biases toward desired, skeptical responses). Our hindsight-bias procedure ...
Tópico(s): Academic and Historical Perspectives in Psychology
2010 - Springer Science+Business Media | Psychonomic Bulletin & Review
Erica Larschan, Eric Bishop, Peter V. Kharchenko, Leighton J. Core, John T. Lis, Peter J. Park, Mitzi I. Kuroda,
Different organisms use a variety of mechanisms to compensate for X chromosome dosage imbalance between the sexes. In Drosophila, the MSL (Male-specific lethal) complex increases transcription on the single X chromosome of males and is thought to regulate transcription elongation, although mechanistic details have been unclear. A global run-on sequencing technique has now been used to reveal that the MSL complex seems to enhance transcription by facilitating the progression of RNA polymerase II across ...
Tópico(s): Chromosomal and Genetic Variations
2011 - Nature Portfolio | Nature
Nasun Hah, Charles G. Danko, Leighton J. Core, Joshua J. Waterfall, Adam Siepel, John T. Lis, W. Lee Kraus,
(Cell 145, 622-634; May 13, 2011) In the color-coded key of Figure S1B in the above article, “S” and “G0/G1” were inadvertently switched. A corrected version of Figure S1 is shown below. Approximately 60%–70% of the cells in each condition are in G0/G1. A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer CellsHah et al.CellMay 5, 2011In BriefWe report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using global run- ...
Tópico(s): Cancer-related molecular mechanisms research
2011 - Cell Press | Cell
Irene M. Min, Joshua J. Waterfall, Leighton J. Core, Robert J. Munroe, John C. Schimenti, John T. Lis,
Transitions between pluripotent stem cells and differentiated cells are executed by key transcription regulators. Comparative measurements of RNA polymerase distribution over the genome's primary transcription units in different cell states can identify the genes and steps in the transcription cycle that are regulated during such transitions. To identify the complete transcriptional profiles of RNA polymerases with high sensitivity and resolution, as well as the critical regulated steps upon which ...
Tópico(s): CRISPR and Genetic Engineering
2011 - Cold Spring Harbor Laboratory Press | Genes & Development
Nasun Hah, Charles G. Danko, Leighton J. Core, Joshua J. Waterfall, Adam Siepel, John T. Lis, W. Lee Kraus,
We report the immediate effects of estrogen signaling on the transcriptome of breast cancer cells using global run-on and sequencing (GRO-seq). The data were analyzed using a new bioinformatic approach that allowed us to identify transcripts directly from the GRO-seq data. We found that estrogen signaling directly regulates a strikingly large fraction of the transcriptome in a rapid, robust, and unexpectedly transient manner. In addition to protein-coding genes, estrogen regulates the distribution ...
Tópico(s): Genomics and Chromatin Dynamics
2011 - Cell Press | Cell
Vivek S. Chopra, David A. Hendrix, Leighton J. Core, Chiahao Tsui, John T. Lis, Michael Levine,
Tópico(s): Genomics and Chromatin Dynamics
2011 - Elsevier BV | Molecular Cell
Abbie Saunders, Leighton J. Core, John T. Lis,
Tópico(s): RNA and protein synthesis mechanisms
2006 - Nature Portfolio | Nature Reviews Molecular Cell Biology
... by Marcell and Ellen [[11]Marcell A. Ellen J. Core sexual/reproductive health care to deliver to male ...
Tópico(s): HIV/AIDS Research and Interventions
2012 - Elsevier BV | Journal of Adolescent Health
Nicklas Selander, Brady T. Worrell, Valery V. Fokin,
... 128X(87)90016-X CASPubMedGoogle Scholar 1jR. Baudouy, J. Core, L. Ruest, Tetrahedron 1987, 43, 1099; 10.1016/ ...
Tópico(s): Synthesis and Catalytic Reactions
2012 - Wiley | Angewandte Chemie
Benjamin Terrier, Alexandre Karras, Philippe Cluzel, Jean‐Philippe Collet, D. Sène, David Saadoun, P. Cacoub,
... M. Tokuhisa T. Iwao H. Takeuchi K. Yoshikawa J. Core protein of hepatitis C virus induces cardiomyopathy.Circ ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2012 - Elsevier BV | The American Journal of Cardiology
Yoshio Matsui, Michael F. O’Rourke, Joji Ishikawa, Kazuyuki Shimada, Kazuomi Kario,
We aimed to investigate the association of the change in the ambulatory arterial stiffness index (AASI) with that in carotid-femoral pulse wave velocity (cfPWV) during treatment with antihypertensive medication.We enrolled 207 hypertensive patients treated with olmesartan monotherapy for 12 weeks. Patients were randomly assigned to treatment with hydrochlorothiazide (HCTZ; n = 104) or azelnidipine (n = 103) for 24 weeks. The cfPWV and 24-h ambulatory blood pressure monitoring (ABPM) results were assessed ...
Tópico(s): Heart Rate Variability and Autonomic Control
2012 - Oxford University Press | American Journal of Hypertension
Nilabhra Bhattacharya, Hemang Desai, Kumar Venkataraman,
... 364. 10.1561/0500000003 Google Scholar Armstrong, C., J. Core, D. Taylor, and R. Verrecchia. 2011. When does ...
Tópico(s): Financial Reporting and Valuation Research
2012 - Wiley | Contemporary Accounting Research
Nicholas J. Fuda, Martin S. Buckley, Wenxiang Wei, Leighton J. Core, Colin T. Waters, Danny Reinberg, John T. Lis,
Fcp1 dephosphorylates the C-terminal domain of the largest subunit of RNA polymerase II (Pol II) to recycle it into a form that can initiate a new round of transcription. Previously, we identified Drosophila Fcp1 as an important factor in optimal Hsp70 mRNA accumulation after heat shock. Here, we examine the role of Fcp1 in transcription of heat shock genes in vivo. We demonstrate that Fcp1 localizes to active sites of transcription including the induced Hsp70 gene. The reduced Hsp70 mRNA accumulation ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - Taylor & Francis | Molecular and Cellular Biology
Alejandra R. Díaz, Leighton J. Core, Min Jiang, Michela Morelli, Christina Chiang, Hendrik Szurmant, Marta Perego,
ABSTRACT Rap proteins in Bacillus subtilis regulate the phosphorylation level or the DNA-binding activity of response regulators such as Spo0F, involved in sporulation initiation, or ComA, regulating competence development. Rap proteins can be inhibited by specific peptides generated by the export-import processing pathway of the Phr proteins. Rap proteins have a modular organization comprising an amino-terminal alpha-helical domain connected to a domain formed by six tetratricopeptide repeats (TPR). ...
Tópico(s): Bacteriophages and microbial interactions
2012 - American Society for Microbiology | Journal of Bacteriology
Leighton J. Core, Joshua J. Waterfall, Daniel A. Gilchrist, David C. Fargo, Hojoong Kwak, Karen Adelman, John T. Lis,
Recent genome-wide studies in metazoans have shown that RNA polymerase II (Pol II) accumulates to high densities on many promoters at a rate-limited step in transcription. However, the status of this Pol II remains an area of debate. Here, we compare quantitative outputs of a global run-on sequencing assay and chromatin immunoprecipitation sequencing assays and demonstrate that the majority of the Pol II on Drosophila promoters is transcriptionally engaged; very little exists in a preinitiation or ...
Tópico(s): RNA modifications and cancer
2012 - Cell Press | Cell Reports