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Artigo Acesso aberto Revisado por pares

Sean R. Moore, Louise S. Gresham, M. B Bromberg, Edward J. Kasarkis, Richard Smith,

The development and validation of the Center for Neurologic Study-Lability Scale (CNS-LS), the first self report measure of affective lability in patients with amyotrophic lateral sclerosis (ALS).Potential questionnaire items were identified through interviews with patients and families and expert review. Potential items, as well as measures of affect intensity, affective lability in psychopathology, and depression were administered to 99 patients with ALS for item selection and the examination of ...

Tópico(s): Parkinson's Disease Mechanisms and Treatments

1997 - BMJ | Journal of Neurology Neurosurgery & Psychiatry

Jornais Acesso aberto

Robert Murphy U. S. Deputy Under-Secretary, L. J. Corbett, John Butt, J. J. R. Trethowan, John Henderson, John West, Richard Buckle, Clarence Elliott, Patrick Nicholson Representative of The Sunday Times, Elizabeth Nicholas, Harold Hobson, Janice Elliott, James Margach Political Correspondent of The Sunday Times, J. D. Scott, Kenneth Pearson, Louis Auchincloss, F. Fioretta, C. V. Hancock, Moira Keenan, Betty F. R. Paterson, Richard Kellett, Joyce Emerson, Elizabeth Pakenham, Henry Brandon, Sir Arthur Bryant, Ida Meyer-Chagall, Lewis S. Baker, Hugh Wynn, Arthur Jenkins, Rev. Sidney M. Berry D. D, Vivian Jenkins, Susan Pulbrook, J. S., Timothy, Stella Frank, Cyril Connolly, Bernard Fergusson Special Representative of The Sunday Times, Ian Fleming, J. F. Colquhoun, Sir Miles Thomas, Gabriel V. Jaffe, Fred Hoyle, F. R. Waterman, Edwin Cambrensis, Raymond Mortimer, Frank M. Wiseman, Nicholas Carroll Diplomatic Correspondent of The Sunday Times, Henry Brandon Representative of The Sunday Times, Michael A. Woolf, Peter Cranmer, H. W. Clear, T. S. Blake, Sam Rabin, Roger Mortimer, James Wilson, Antony Terry Representative of The Sunday Times, Ernestine Carter, Desmond Shawe-Taylor, Francis Fogarty Director-General, R. L. Hollands, Maurice Hope, R. C. Robertson-Glasgow, J. B. Slade-Baker The Sunday Times Representative, Anne Morland, Dilys Powell, Lord Morrison, E. J. Dingwall, R. E. Smith, A. E. Housman, John Henderson Representative of The Sunday Times, David Howarth Author of the best-selling books, Merlin, Felix Aprahamian, Stephen Coulter The Sunday Times Representative, Margaret Costa, Robert Robinson, Henry Longhurst, Peter Collins, Basil Taylor, Brian Glanville, Edith Sitwell, Iain Lang, Robert Holles, Gerald Gibbs, Mordecai Richler, J. W. Robinson, C. H. O'd. Alexander, George Schwartz, John Bowen, Maurice Wiggin, Gordon Ross, B. A. Chacksfield, Rt. Hon. R. G. Menzies Prime Minister, James Evans, Susan Cooper, Rt. Hon. Hugh Gaitskell, Kenneth Konstam, Hugh Trevor-Roper, Harold Hanbury,

... casual Blackburn Webster Makes Havoc of Charlton Defence Bromberg Surprises Radford The Results Miss Rowe in Last ...

1960 - Gale Group | Sunday Times HA GDA

Artigo Acesso aberto Revisado por pares

Jonathan S. Bromberg, Edward J. Alfrey, Clyde F. Barker, Kenneth D. Chavin, Donald C. Dafoe, TERRI HOLLAND, Ali Naji, Leonard J. Perloff, Lydia Zellers, Robert Grossman,

The use of increased dosages of glucocorticoids during periods of physiologic stress in allograft recipients represents a clinical dilemma in that the short-term exogenous therapy required may significantly impair wound healing and immunocompetence. To investigate whether "stress steroids" are actually necessary, a prospective study was conducted in 40 renal allograft recipients admitted with significant physiologic stress. Stress categories included sepsis, metabolic abnormalities, and surgery. ...

Tópico(s): Hormonal and reproductive studies

1991 - Wolters Kluwer | Transplantation

Artigo Revisado por pares

Connor Scagnelli, Diantha B. Howard, Mark B. Bromberg, Edward J. Kasarskis, Dwight E. Matthews, Hiroshi Mitsumoto, Zachary Simmons, Rup Tandan,

We present a study of hydration in ALS patients and its effects on survival. This was a multicenter study over 48 weeks in 80 ALS patients who underwent 250 individual measurements using doubly labeled water (DLW). Total body water (TBW) and water turnover (a surrogate for water intake) were 3.4% and 8.6% lower, respectively, in patients compared to age- and gender-matched healthy controls, and both significantly decreased over study duration. In 20% of patients, water turnover measured over 10 d was ...

Tópico(s): Electrolyte and hormonal disorders

2017 - Taylor & Francis | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Artigo Revisado por pares

Robert G. Miller, J. Rosenberg, Deborah Gelinas, Hiroshi Mitsumoto, Daniel S. Newman, Robert Sufit, Gian Domenico Borasio, Walter G. Bradley, Mark B. Bromberg, Benjamin Rix Brooks, Edward J. Kasarskis, T. L. Munsat, Edward Anthony Oppenheimer,

Muscle & NerveVolume 22, Issue 8 p. 1104-1118 Special Article Practice parameter: The care of the patient with amyotrophic lateral sclerosis (An evidence-based review) R.G. Miller MD, R.G. Miller MD American Academy of Neurology, 1080 Montreal Ave., St. Paul, MN 55116Search for more papers by this authorJ.A. Rosenberg MD, J.A. Rosenberg MD American Academy of Neurology, 1080 Montreal Ave., St. Paul, MN 55116Search for more papers by this authorD.F. Gelinas MD, D.F. Gelinas MD American Academy of Neurology, ...

Tópico(s): Cervical and Thoracic Myelopathy

1999 - Wiley | Muscle & Nerve

Artigo Revisado por pares

Robert G. Miller, J. Rosenberg, Deborah E. Gelinas, Hiroshi Mitsumoto, Daniel S. Newman, Robert Sufit, Gian Domenico Borasio, Walter G. Bradley, Mark B. Bromberg, Benjamin Rix Brooks, Edward J. Kasarskis, Theodore L. Munsat, Edward Anthony Oppenheimer,

Mission statement. The Quality Standards Subcommittee (QSS) of the American Academy of Neurology (AAN) is charged with developing practice parameters for physicians. This evidence-based review addresses some of the major management issues in patients with ALS, and highlights the many areas in which more research is needed. ALS is a progressive, degenerative motor neuron disease of unknown cause. Muscle atrophy and spasticity in limb and bulbar muscles result in weakness and loss of ambulation, oropharyngeal ...

Tópico(s): Dysphagia Assessment and Management

1999 - SAGE Publishing | Neurorehabilitation and neural repair

Artigo Acesso aberto Revisado por pares

Nancy Krieger, Daniel Most, J S Bromberg, Bari Holm, Philip Huie, Richard K. Sibley, Donald C. Dafoe, Edward J. Alfrey,

Anti-CD2 monoclonal antibody OX34 has been shown to suppress immunity in rodents in vitro and in vivo. To evaluate the effects of OX34 on vascularized allografts, Lewis (RT1(1)) hearts were transplanted heterotopically into Wistar Furth (RT1(u)) rats. A single 5 mg/kg intraperitoneal dose of OX34 administered at transplantation induced indefinite graft survival (mean survival time >140.3+/-12.3 vs. 12.7+/-0.7 control, P=0.001). The mixed lymphocyte response was partially inhibited at 60 days after transplant, ...

Tópico(s): Immune Response and Inflammation

1996 - Wolters Kluwer | Transplantation

Artigo Revisado por pares

Daniel J. Auerbach, Edward E. A. Bromberg, Lennard Wharton,

Space focusing of molecular beams is an established technique achieved by multipole fields for molecules in states that gain energy with applied field. Very often, however, one wants to focus molecules in states that lose energy with applied field. This latter problem is discussed here, and it is shown that the technique called ``strong'' or ``alternate-gradient,'' AG, focusing is of quite general applicability. The dipole, ``two-wire'' field is shown to be the neutral beam analog of the magnetic or electric ...

Tópico(s): Atomic and Molecular Physics

1966 - American Institute of Physics | The Journal of Chemical Physics

Artigo Acesso aberto Revisado por pares

A A Cohen, Cornelius J. Nelson, Steven M. Bromberg, M Pravda, Edward F. Ferrand, Giovanna Leone,

Symptom reporting during recent publicized and unpublicized air pollution episodes. A A Cohen, C J Nelson, S M Bromberg, M Pravda, E F Ferrand, and G LeoneCopyRight https://doi.org/10.2105/AJPH.64.5.442 Published Online: October 07, 2011

Tópico(s): Air Quality and Health Impacts

1974 - American Public Health Association | American Journal of Public Health

Artigo Acesso aberto Revisado por pares

Meghan Karuturi, Nirav N. Shah, Dale Frank, Omotayo Fasan, Ran Reshef, Vivek N. Ahya, Michael Bromberg, Thomas W. Faust, Simin Göral, Stephen J. Schuster, Edward A. Stadtmauer, Donald E. Tsai,

Post-transplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation. Although PTLD typically has a B-cell histology, an uncommon variant, plasmacytic PTLD can present as a monoclonal plasma cell proliferation similar to plasmacytomas seen in multiple myeloma. A retrospective analysis was performed on nine patients at our center with plasmacytic PTLD as characterized by plasmacytic histology with the presence of CD138 and lack of CD20. Of the 210 adult solid organ ...

Tópico(s): Multiple Myeloma Research and Treatments

2013 - Springer Science+Business Media | Transplant International

Artigo Revisado por pares

Kevin M. Flanigan, Mark B. Bromberg, M. M. Gregory, J. Richard Baringer, Charles Ray Jones, Theresa A. Nester, Edward C. Klatt, Jeannette J. Townsend,

Background: Among the complications of chronic renal failure is a syndrome of medial calcification of small- to medium-sized arteries associated with ischemic necrosis of the skin and other organ systems, leading to gangrene and a poor prognosis. The syndrome has been reviewed in the renal, dermatologic, and surgical literature under the term calciphylaxis , which describes a postulated pathogenetic mechanism whereby sensitization to an endogenous or exogenous substance (such as parathyroid hormone) predisposes ...

Tópico(s): Inflammatory Myopathies and Dermatomyositis

1998 - Lippincott Williams & Wilkins | Neurology

Artigo Revisado por pares

Sonja S. Hutchins, Robert W. Amler, Edward F. Maes, Mark Grabowsky, Kenneth Bromberg, Victoria Glasglow, Terence P. Speed, William J. Bellini,

An accurate system of identifying and classifying suspected measles cases is critical for the measles surveillance system in the United States. To examine the performance of the clinical case definition in predicting laboratory confirmation of suspected cases of measles, we reviewed 4 studies conducted between 1981 and 1994. A clinical case definition was examined that included a generalized maculopapular rash, fever(5=38.3°C, if measured), and either a cough, coryza, or conjunctivitis. Serological ...

Tópico(s): Syphilis Diagnosis and Treatment

2004 - Oxford University Press | The Journal of Infectious Diseases

Artigo Acesso aberto Revisado por pares

Donald C. Dafoe, Jonathan S. Bromberg, Robert Grossman, John E. Tomaszewski, Chester M. Zmijewski, Leonard J. Perloff, Ali Naji, MARK W. ASPLUND, Edward J. Alfrey, Martha J. Sack, Lydia Zellers, Jane Kearns, Clyde F. Barker,

The antiglobulin crossmatch (AGXM) is a sensitive technique employed by many transplant centers to enhance detection of preformed antibody to donor antigens that may cause hyperacute rejection. However, positive AGXM may detect irrelevant or very low titers of anti-HLA antibody precluding transplantation in suitable recipients. To investigate the significance of a positive AGXM, cadaveric renal transplantation was carried out despite a weakly positive AGXM (defined as cell killing above background ...

Tópico(s): RNA modifications and cancer

1991 - Wolters Kluwer | Transplantation

Revisão Acesso aberto Revisado por pares

James M. Samet, Hao Chen, Edward Ross Pennington, Philip A. Bromberg,

Metallic compounds contribute to the oxidative stress of ambient particulate matter (PM) exposure. The toxicity of redox inert ions of cadmium, mercury, lead and zinc, as well as redox-active ions of vanadium and chromium is underlain by dysregulation of mitochondrial function and loss of signaling quiescence. Central to the initiation of these effects is the interaction of metal ions with cysteinyl thiols on glutathione and key regulatory proteins, which leads to impaired mitochondrial electron ...

Tópico(s): Air Quality and Health Impacts

2019 - Elsevier BV | Free Radical Biology and Medicine

Artigo Revisado por pares

Victoria Higgins, Man Khun Chan, Michelle Nieuwesteeg, Barry Hoffman, Irvin L. Bromberg, Doug Gornall, Edward Randell, Khosrow Adeli,

The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has recently established pediatric age- and sex-specific reference intervals for over 85 biochemical markers on the Abbott Architect system. Previously, CALIPER reference intervals for several biochemical markers were successfully transferred from Abbott assays to Roche, Beckman, Ortho, and Siemens assays. This study further broadens the CALIPER database by performing transference and verification for 52 biochemical assays ...

Tópico(s): Antibiotics Pharmacokinetics and Efficacy

2015 - Elsevier BV | Clinical Biochemistry

Artigo Acesso aberto Revisado por pares

Edward J. Kasarskis, Marta S. Mendiondo, Dwight E. Matthews, Hiroshi Mitsumoto, Rup Tandan, Zachary Simmons, Mark B. Bromberg, Richard J. Kryscio,

Patients with amyotrophic lateral sclerosis (ALS) experience progressive limb weakness, muscle atrophy, and dysphagia, making them vulnerable to insufficient energy intake. Methods to estimate energy requirements have not been devised for this patient group.The goal was to develop equations to estimate energy requirements of ALS patients.We enrolled 80 ALS participants at varying stages of their illness and studied them every 16 wk over 48 wk. At each time, we determined total daily energy expenditure ( ...

Tópico(s): Child Nutrition and Feeding Issues

2014 - Elsevier BV | American Journal of Clinical Nutrition

Artigo Acesso aberto Revisado por pares

Michael R. Michaelides, Arthur F. Kluge, Michael A. Patane, John H. Van Drie, Ce Wang, Terkel Hansen, Roberto M. Risi, Robert A. Mantei, Carmen Hertel, Kannan R. Karukurichi, Alexandre Nesterov, David McElligott, Peter de Vries, J. William Langston, Philip A. Cole, Ronen Marmorstein, Hong Liu, Loren Lasko, Kenneth D. Bromberg, Albert Lai, Edward A. Kesicki,

p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been identified through virtual ligand screening and subsequent optimization of a unique hydantoin screening hit. Conformational restraint in the form of a spirocyclization followed by substitution with a urea led to a significant ...

Tópico(s): Ubiquitin and proteasome pathways

2017 - American Chemical Society | ACS Medicinal Chemistry Letters

Revisão

Hiroshi Mitsumoto, Mark B. Bromberg, Wendy Johnston, Rup Tandan, Ira Byock, Mary Lyon, Robert G. Miller, Stanley H. Appel, Josh Benditt, James L. Bernat, Gian Domenico Borasio, Alan Carver, Lora Clawson, M. L. Del Bene, Edward J. Kasarskis, Susan B. LeGrand, Raúl N. Mandler, Jane McCarthy, Theodore L. Munsat, Daniel S. Newman, Robert Sufit, Andrea Versenyi,

The type and quality of end‐of‐life care varies greatly in ALS; the time to initiate end‐of‐life care is not defined, and decision making is hampered by logistical and financial barriers. There has been no systematic review of these issues in ALS. The goals of this initiative are to: 1) improve end‐of‐life care for patients with ALS and families based on what limited evidence is available; 2) increase awareness, interest, and debate on the end‐of‐life care in ALS; and 3) identify areas needed for ...

Tópico(s): Healthcare Decision-Making and Restraints

2005 - Taylor & Francis | Amyotrophic Lateral Sclerosis

Artigo Revisado por pares

David Sterritt, Chelsea Wayant, Martin Stollery, Andrew David,

... John Ireland (Bob Ford), Reed Hadley (Jesse James), J. Edward Bromberg (Kane), Victor Kilian (Soapy), Tom Tyler (Frank James), ...

Tópico(s): Art, Politics, and Modernism

2009 - Intellect | Film International

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Cinthia B. Drachenberg, José Torrealba, Brian J. Nankivell, Érika Bevilaqua Rangel, Ingeborg M. Bajema, D.U. Kim, Lois J. Arend, Erika Bracamonte, Jonathan S. Bromberg, Jan A. Bruijn, Diego Cantarovich, Jeremy R. Chapman, Alton B. Farris, Lillian W. Gaber, J. Goldberg, Abdolreza Haririan, Eva Honsová, Samy S. Iskandar, David K. Klassen, Edward S. Kraus, Fritz Lower, Jon S. Odorico, Jean L. Olson, Anuja Mittalhenkle, Raghava Munivenkatappa, Steven Paraskevas, John C. Papadimitriou, Parmjeet Randhawa, Finn P. Reinholt, Karine Renaudin, P. Revelo, Phillip Ruiz, Milagros Samaniego, Robert Shapiro, Robert J. Stratta, David E.R. Sutherland, Megan L. Troxell, Luděk Voska, Surya V. Seshan, Lorraine C. Racusen, Stephen T. Bartlett,

The first Banff proposal for the diagnosis of pancreas rejection (Am J Transplant 2008; 8: 237) dealt primarily with the diagnosis of acute T-cell-mediated rejection (ACMR), while only tentatively addressing issues pertaining to antibody-mediated rejection (AMR). This document presents comprehensive guidelines for the diagnosis of AMR, first proposed at the 10th Banff Conference on Allograft Pathology and refined by a broad-based multidisciplinary panel. Pancreatic AMR is best identified by a combination ...

Tópico(s): Organ Transplantation Techniques and Outcomes

2011 - Elsevier BV | American Journal of Transplantation

Artigo Acesso aberto Revisado por pares

Brian T. Weinert, Takeo Narita, Shankha Satpathy, Balaji Srinivasan, Bogi Karbech Hansen, Christian Schölz, William B. Hamilton, Beth E. Zucconi, Wei Wang, Wenshe Ray Liu, Joshua M. Brickman, Edward A. Kesicki, Albert Lai, Kenneth D. Bromberg, Philip A. Cole, Chunaram Choudhary,

The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here, we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors, bromodomain inhibitor, and gene knockout to reveal a comprehensive map of regulated acetylation sites and their dynamic turnover rates. CBP/p300 acetylates thousands of sites, including signature histone sites and a multitude of sites on signaling effectors and enhancer-associated transcriptional regulators. Time-resolved acetylome ...

Tópico(s): Ubiquitin and proteasome pathways

2018 - Cell Press | Cell

Artigo Acesso aberto Revisado por pares

Summer Gibson, Edward J. Kasarskis, Nan Hu, Stefan-M. Pulst, Marta S. Mendiondo, Dwight E. Matthews, Hiroshi Mitsumoto, Rup Tandan, Zachary Simmons, Richard J. Kryscio, Mark B. Bromberg,

Our objective was to explore if creatine kinase (CK) levels correlate with survival in amyotrophic lateral sclerosis (ALS), and whether a correlation is independent of other well-studied predictors such as location of onset, gender, age, fat free mass, spasticity, cramps, and fasciculations. We analyzed data from 80 ALS patients from a 48-week non-interventional longitudinal multicenter nutrition study with long term follow-up. The overall mean CK was 214 ± 191.8 U/l (range 22–1992 U/l). Forty-five percent ...

Tópico(s): Genetic Neurodegenerative Diseases

2015 - Taylor & Francis | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Artigo Acesso aberto Revisado por pares

Amy R. Deipolyi, Christopher C. Riedl, Jacqueline Bromberg, Sarat Chandarlapaty, Christopher A. Klebanoff, Constantinos T. Sofocleous, Hooman Yarmohammadi, Lynn A. Brody, F. Edward Boas, Etay Ziv,

Abstract Purpose To describe imaging response and survival after radioembolization for metastatic breast cancer and to delineate genetic predictors of imaging responses and outcomes. Materials and Methods This retrospective study included 31 women (average age, 52 y) with liver metastasis from invasive ductal carcinoma who underwent resin and glass radioembolization (average cumulative dose, 2.0 GBq ± 1.8) between January 2011 and September 2017 after receiving ≥ 3 lines of chemotherapy. Twenty-four underwent ...

Tópico(s): Radiopharmaceutical Chemistry and Applications

2018 - Elsevier BV | Journal of Vascular and Interventional Radiology

Artigo Acesso aberto Revisado por pares

Chunfeng Qu, Emmerson W. Edwards, Frank Tacke, Véronique Angeli, Jaime Llodrá, Guzman Sánchez‐Schmitz, Alexandre Garin, Nasreen S. Haque, Wendy Peters, Nico van Rooijen, Carmen Sánchez‐Torres, Jonathan S. Bromberg, Israel Charo, Steffen Jung, Sérgio A. Lira, Gwendalyn J. Randolph,

Studying the influence of chemokine receptors (CCRs) on monocyte fate may reveal information about which subpopulations of monocytes convert to dendritic cells (DCs) and the migration pathways that they use. First, we examined whether prominent CCRs on different monocyte subsets, CCR2 or CX3CR1, mediated migration events upstream of the accumulation of monocyte-derived DCs in lymph nodes (LNs). Monocytes were labeled and traced by uptake of latex microspheres in skin. Unexpectedly, neither CCR2 nor ...

Tópico(s): T-cell and B-cell Immunology

2004 - Rockefeller University Press | The Journal of Experimental Medicine