Ernest Newman, H. E. Cooper, H. M. Abrahams, A. T. Johnson, Angus Davidson, Henry Longhurst, Hubert Winterbotham, Laurence Faraday, Roland H. Tudor (Lecturer), I. G. W., M. Laval, A. R. Powys (Secretary), L. R., G. W. B., G. N. Ortsel, Yarborough, E. G. Winstanley, A. A. Part, Dr. C. A. Alingtom, Ralph Straus, Mr. Llyod George, "Scrutator", George Easton Colonel, J. B. Firth, J. M. Bulloch, (Mrne.) Jane Meyerheim (Officer), E. V. Lucas, James Agate, Frank Rutter, E. L., Denis B. Brown, W. Kent, Muriel Beckwith, Ernest Beels, Sydney W. Carroll, Hultonian, B. H. Musslewhite, Dilys Ward, J. J. Raftery, Thames, D. R. Gent, Chas. W. Morrison, R. Jack Stone, Hilda Cooke, Richard Cromwell, Dr. C. A. Alington, E. H. Blakeney, "Atticus", "Mankato", B. M., "Fairway", Lord Chamberlain, Ernest A. Ebblewhite, Edward A. Bunyard, Desmond MacCARTHY, C. P. Hawkes Lieut-Colonel, C. H. P. Lamond, Edward Shanks, George W. Bishop, W. MAcLEAN Homan, R. A. C. Wellesley, Gilbert Thomas, Andre L. Simon, H. F., Rowland H. Hill, G. L. Rogers, Pandora, L. Minchella (Secretary, Anglo-italian Club), Richard Gillbard, Leonard C. Wood President, Lord Carson, R. J. Barrett Financial Editor, Peter Bousfield, D. Montgomerie, W. H. Parr,
... Venables First Ceremony at School Chapel Dr. George Antonoff and Mme. Levinskaya Mr. C. Hilary Westron and ...
1935 - Gale Group | Sunday Times HA GDA
David B. Nelson, Nabihah Tayob, K. G. Mitchell, Arlene M. Correa, Wayne L. Hofstetter, Boris Sepesi, Garrett L. Walsh, Ara A. Vaporciyan, Stephen G. Swisher, Mara B. Antonoff, Jack A. Roth, David C. Rice, Jean‐Nicolas Vauthey, Reza J. Mehran,
ObjectiveDuring resection of pulmonary metastases, the need to spare lung parenchyma is often weighed against the increased risk of local recurrence if an inadequate surgical margin is obtained. We sought to identify risk factors for local recurrence after wedge resection of pulmonary metastases of a colorectal origin.MethodsA retrospective study of patients who underwent a wedge resection for colorectal pulmonary metastases from 2006 to 2016 was performed. Cox regression with robust variance was ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
K. G. Mitchell, Edwin R. Parra, Jiexin Zhang, David B. Nelson, Erin M. Corsini, Pamela Villalobos, César A. Moran, Ferdinandos Skoulidis, Ignacio I. Wistuba, Junya Fujimoto, Jack A. Roth, Mara B. Antonoff, J. Jack Lee, Ara A. Vaporciyan, Wayne L. Hofstetter, Reza J. Mehran, Stephen G. Swisher, David C. Rice, Boris Sepesi, Garrett L. Walsh, Carmen Behrens, Neda Kalhor, Annikka Weissferdt, John V. Heymach, John V. Heymach, AstraZeneca, Bayer, GlaxoSmithKline,
BackgroundMutations in the serine/threonine kinase 11 (STK11)/liver kinase B1 (LKB1) have been implicated in mediating resistance to checkpoint blockade among patients with advanced lung adenocarcinoma. We sought to examine the associations between clinicopathologic characteristics, tumor LKB1 expression, features of the immune microenvironment, and postoperative prognosis among patients with early stage lung adenocarcinoma undergoing surgical therapy.MethodsFormalin-fixed, paraffin-embedded specimens ...
Tópico(s): Cancer Genomics and Diagnostics
2020 - Elsevier BV | The Annals of Thoracic Surgery
David C. Rice, Andrea Rodríguez-Restrepo, Gabriel E. Mena, Juan P. Cata, Peter F. Thall, Denái R. Milton, Arlene M. Correa, TaCharra Woodard, Mara B. Antonoff, Wayne L. Hofstetter, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Garrett L. Walsh, Ara Vaporciyan, Reza J. Mehran,
Objective: The aim of this study was to assess the effect of an enhanced recovery after surgery (ERAS) pathway on pain and opioid use following lung resection. Summary Background Data: A major component ERAS pathways is opioid-sparing analgesia; however, the effect on postoperative pain and opioid use in patients undergoing lung resection is unknown. Methods: Following implementation of an ERAS pathway for lung resection, 123 consecutive patients were identified. Patients were propensity-matched ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2020 - Lippincott Williams & Wilkins | Annals of Surgery
David Nelson, Reza J. Mehran, K. G. Mitchell, Ravi Rajaram, Arlene M. Correa, Roland L. Bassett, Mara B. Antonoff, Wayne L. Hofstetter, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Garrett L. Walsh, Ara A. Vaporciyan, David C. Rice,
Background It is unclear whether the enhanced dexterity and visualization of the surgical robot lessens morbidity and influences staging or survival. We compared outcomes of robotic-assisted lobectomy (RAL) with thoracoscopic video-assisted lobectomy (VAL) or open lobectomy (OL) of non-small cell lung cancer. Methods Using a prospective surgical database, perioperative and cancer-related outcomes of patients who received a lobectomy for non-small cell lung cancer from 2011 to 2017 were analyzed. Outcomes between ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2019 - Elsevier BV | The Annals of Thoracic Surgery
Nicolas Zhou, David C. Rice, Anne S. Tsao, Percy P. Lee, Cara Haymaker, Erin M. Corsini, Mara B. Antonoff, Wayne L. Hofstetter, Ravi Rajaram, Jack A. Roth, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Reza J. Mehran, Boris Sepesi,
Background Whether extrapleural pneumonectomy (EPP) or extended pleurectomy/decortication (P/D) is the optimal resection for malignant pleural mesothelioma remains controversial. We therefore compared perioperative outcomes and long-term survival of patients who underwent EPP versus P/D. Methods Patients with the diagnosis of malignant pleural mesothelioma who underwent either EPP or P/D from 2000 to 2019 were identified from our departmental database. Propensity score matching was performed to minimize ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2021 - Elsevier BV | The Annals of Thoracic Surgery
David B. Nelson, K. G. Mitchell, Brian Weston, Sonia L. Betancourt, Dipen M. Maru, David C. Rice, Reza J. Mehran, Boris Sepesi, Mara B. Antonoff, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Ara A. Vaporciyan, Mariela A. Blum, Wayne L. Hofstetter,
Endoscopic mucosal resection (EMR) can be an effective therapy for superficial esophageal cancer. Many patients with cT2 invasion by endoscopic ultrasound (EUS) receive surgery but are subsequently found to have superficial disease. The purpose of this study was to investigate the safety profile and the added value of attempting EMR for EUS-staged cT2N0 esophageal cancer. A retrospective review was performed at a single institution from 2008 to 2017. Patients who were staged cT2N0 by EUS were identified ...
Tópico(s): Gastric Cancer Management and Outcomes
2019 - Oxford University Press | Diseases of the Esophagus
K. G. Mitchell, Naruhiko Ikoma, David B. Nelson, Dipen M. Maru, Jeremy J. Erasmus, Brian Weston, Ara A. Vaporciyan, Mara B. Antonoff, Reza J. Mehran, David C. Rice, Jack A. Roth, Stephen G. Swisher, Boris Sepesi, Garrett L. Walsh, Arlene M. Correa, Prajnan Das, Mariela A. Blum, Brian D. Badgwell, Wayne L. Hofstetter,
BackgroundAdenocarcinoma of the gastroesophageal junction (AEG) poses a management challenge, as preoperative prediction of occult mediastinal nodal metastasis is difficult. We sought to identify factors predictive of mediastinal involvement among patients undergoing trimodality therapy.MethodsPatients undergoing trimodality therapy for Siewert II and III AEG at a single institution between 2000 and 2015 were identified. Mediastinal involvement was defined as pathologic nodal involvement after neoadjuvant ...
Tópico(s): Esophageal and GI Pathology
2019 - Elsevier BV | The Annals of Thoracic Surgery
K. G. Mitchell, David B. Nelson, Erin M. Corsini, Ara A. Vaporciyan, Mara B. Antonoff, Reza J. Mehran, David C. Rice, Jack A. Roth, Boris Sepesi, G. Walsh, Manisha Bhutani, Dipen M. Maru, Chen-Yu Wu, Q-N Nguyen, Jaffer A. Ajani, Stephen G. Swisher, Wayne L. Hofstetter,
SUMMARY The survival advantage associated with the addition of surgical therapy in esophageal squamous cell carcinoma (ESCC) patients who demonstrate a complete clinical response to chemoradiotherapy is unclear, and many institutions have adopted an organ-preserving strategy of selective surgery in this population. We sought to characterize our institutional experience of salvage esophagectomy (for failure of definitive bimodality therapy) and planned esophagectomy (as a component of trimodality therapy) ...
Tópico(s): Gastric Cancer Management and Outcomes
2019 - Oxford University Press | Diseases of the Esophagus
Ravi Rajaram, Arlene M. Correa, Ting Xu, Quynh-Nhu Nguyen, Mara B. Antonoff, David C. Rice, Reza J. Mehran, Jack A. Roth, Garrett L. Walsh, Stephen G. Swisher, Wayne L. Hofstetter, Ara A. Vaporciyan, Tina Cascone, Anne S. Tsao, Vassiliki A. Papadimitrakopoulou, Saumil Gandhi, Zhongxing Liao, Boris Sepesi,
Introduction The standard of care for stage IIIA (N2) non–small-cell lung cancer (NSCLC) includes concurrent definitive chemoradiation (dCRT) followed by durvalumab, thus challenging the role of surgery in resectable patients. We assessed locoregional disease control and survival in patients with surgically resected and unresected stage IIIA (N2) NSCLC disease. Patients and Methods We conducted a retrospective analysis from prospectively collected databases at MD Anderson Cancer Center. Patients undergoing ...
Tópico(s): Lung Cancer Research Studies
2020 - Elsevier BV | Clinical Lung Cancer
Tina Cascone, William N. William, Annikka Weissferdt, Cheuk Hong Leung, Heather Lin, Apar Pataer, Myrna C. B. Godoy, Brett W. Carter, Lorenzo Federico, Alexandre Reuben, M.A. Wadud Khan, Hitoshi Dejima, Alejandro Francisco‐Cruz, Edwin R. Parra, Luisa M. Solis, Junya Fujimoto, Hai T. Tran, Neda Kalhor, Frank V. Fossella, Frank E. Mott, Anne S. Tsao, George Blumenschein, Xiuning Le, Jianjun Zhang, Ferdinandos Skoulidis, Jonathan M. Kurie, Mehmet Altan, Charles Lu, Bonnie S. Glisson, Lauren A. Byers, Yasir Y. Elamin, Reza J. Mehran, David C. Rice, Garrett L. Walsh, Wayne L. Hofstetter, Jack A. Roth, Mara B. Antonoff, Humam Kadara, Cara Haymaker, Chantale Bernatchez, Nadim J. Ajami, Robert R. Jenq, Padmanee Sharma, James P. Allison, P. Andrew Futreal, Jennifer A. Wargo, Ignacio I. Wistuba, Stephen G. Swisher, J. Jack Lee, Don L. Gibbons, Ara A. Vaporciyan, John V. Heymach, Boris Sepesi,
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 randomized NEOSTAR trial (NCT03158129) of neoadjuvant nivolumab or nivolumab + ipilimumab followed by surgery in 44 patients with operable NSCLC, using major pathologic response (MPR) as the primary endpoint. The MPR rate for each treatment arm was tested against ...
Tópico(s): Lung Cancer Treatments and Mutations
2021 - Nature Portfolio | Nature Medicine
K. G. Mitchell, Edwin R. Parra, David B. Nelson, Jiexin Zhang, Ignacio I. Wistuba, Junya Fujimoto, Jack A. Roth, Mara B. Antonoff, Erin M. Corsini, Ara A. Vaporciyan, Wayne L. Hofstetter, Reza J. Mehran, Stephen G. Swisher, David C. Rice, Boris Sepesi, Garrett L. Walsh, Carmen Behrens, Neda Kalhor, Annikka Weissferdt, César A. Moran, J. Jack Lee,
Abstract Objectives Ki67 is a marker for tumor proliferative activity and is known to have prognostic significance in multiple solid malignancies. We sought to characterize the relationships among Ki67 expression, immune cell infiltration, and immune checkpoint expression in patients with resected non–small cell lung cancer. Methods Specimens of patients undergoing resection of stage I to III non–small cell lung cancer (1997-2012) were analyzed using tissue microarrays. Proliferative index was quantified ...
Tópico(s): Lung Cancer Treatments and Mutations
2019 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Joe Y. Chang, Steven H. Lin, Luyang Yao, Saumil Gandhi, Zhongxing Liao, Stephen G. Chun, Melenda Jeter, James W. Welsh, Percy Lee, Mara B. Antonoff, Lei Feng, J. Jack Lee, John V. Heymach,
9035 Background: Stereotactic Ablative Radiotherapy (SABR) provides > 95% local control and has become standard care of medically inoperable stage I NSCLC. However, cumulatively about 40% of patients develop recurrence in the regional lymph nodes, distant organs, or secondary lung cancer. Combined immunotherapy and SABR (I-SABR) may reduce these recurrences by stimulating stronger cancer specific immune response. Methods: This is an ongoing phase II randomized study (SABR vs. I-SABR) to evaluate the ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Nicolas Zhou, Erin M. Corsini, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, David C. Rice,
Whether robotic segmentectomies are advantageous is unclear. We describe our experience with the robot, comparing patient populations and outcomes with video-assisted thoracoscopic surgery (VATS) and open resection.Patients who underwent anatomic segmentectomy from 2004 to 2019 were reviewed. Resection methods were categorized as robotic, VATS, or open. Segmentectomies were categorized as simple or complex. Baseline characteristics and perioperative outcomes were analyzed from 2015 to 2019 due to ...
Tópico(s): Pleural and Pulmonary Diseases
2021 - Elsevier BV | The Annals of Thoracic Surgery
Joe Y. Chang, Reza J. Mehran, Lei Feng, Vivek Verma, Zhongxing Liao, James W. Welsh, Steven H. Lin, Michael S. O’Reilly, Melenda Jeter, Peter Balter, Stephen E. McRae, Donald A. Berry, John V. Heymach, Jack A. Roth, Mara B. Antonoff, Wayne Hofstetter, Ravi Rajaram, David C. Rice, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, Craig DeGraaf, Arlene M. Correa, Aileen B. Chen, Saumil Gandhi, Ritsuko Komaki, Percy Lee, Quynh‐Nhu Nguyen, Matthew S. Ning, Song Gao, Julianne Pollard‐Larkin, P Nitsch, R Sadagopan, Xiaochun Wang,
A previous pooled analysis of the STARS and ROSEL trials showed higher survival after stereotactic ablative radiotherapy (SABR) than with surgery for operable early-stage non-small-cell lung cancer (NSCLC), but that analysis had notable limitations. This study reports long-term results of the revised STARS trial, in which the SABR group was re-accrued with a larger sample size, along with a protocol-specified propensity-matched comparison with a prospectively registered, contemporary institutional ...
Tópico(s): Head and Neck Cancer Studies
2021 - Elsevier BV | The Lancet Oncology
Jitesh B. Shewale, David Nelson, David C. Rice, Boris Sepesi, Wayne L. Hofstetter, Reza J. Mehran, Ara A. Vaporciyan, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Mara B. Antonoff,
Among patients with previous lung cancer, the malignant potential of subsequent ground-glass opacities (GGOs) on computed tomography remains unknown, with a lack of consensus regarding surveillance and intervention. This study sought to describe the natural history of GGO in patients with a history of lung cancer.A retrospective review was performed of 210 patients with a history of lung cancer and ensuing computed tomography evidence of pure or mixed GGOs between 2007 and 2013. Computed tomography ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2018 - Elsevier BV | The Annals of Thoracic Surgery
David Nelson, Myrna C.B. Godoy, Marcelo F. Benveniste, Jitesh B. Shewale, Jonathan Spicer, K. G. Mitchell, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Boris Sepesi, Garrett L. Walsh, Ara A. Vaporciyan, Stephen G. Swisher, Jack A. Roth, Mara B. Antonoff,
Background Ground glass opacities pose diagnostic challenges, and even after malignancy is confirmed, prognosis is often unclear. We sought to identify clinicoradiographic features that could predict aggressive tumor biology in lung adenocarcinoma with associated ground glass components. Methods A retrospective review of patients with resected lung adenocarcinoma from 2008 to 2013 was performed. Detailed radiographic features were reviewed by two radiologists. Logistic regression was used to identify risks ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2018 - Elsevier BV | The Annals of Thoracic Surgery
Produção Nacional
Revisado por pares
Boris Sepesi, Nicolas Zhou, William N. William, Heather Lin, Cheuk Hong Leung, Annikka Weissferdt, K. G. Mitchell, Apar Pataer, Garrett L. Walsh, David C. Rice, Jack A. Roth, Reza J. Mehran, Wayne L. Hofstetter, Mara B. Antonoff, Ravi Rajaram, Marcelo V. Negrão, Anne S. Tsao, Don L. Gibbons, J. Jack Lee, John V. Heymach, Ara A. Vaporciyan, Stephen G. Swisher, Tina Cascone,
Surgical outcomes for non-small cell lung cancer after neoadjuvant immune checkpoint inhibitors continue to be debated. We assessed perioperative outcomes of patients treated with Nivolumab or Nivolumab plus Ipilimumab (NEOSTAR) and compared them with patients treated with chemotherapy or previously untreated patients with stage I-IIIA non-small cell lung cancer.Forty-four patients with stage I to IIIA non-small cell lung cancer (American Joint Committee on Cancer Staging Manual, seventh edition) ...
Tópico(s): Lung Cancer Treatments and Mutations
2022 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Dario Pasalic, Sonia L. Betancourt‐Cuellar, Nicolette Taku, Ethan B. Ludmir, Yi Lu, Pamela K. Allen, Chad Tang, Mara B. Antonoff, Clifton D. Fuller, D.I. Rosenthal, William H. Morrison, Jack Phan, Adam S. Garden, James W. Welsh, Joe Y. Chang, Zhongxing Liao, Jeremy J. Erasmus, Quynh‐Nhu Nguyen,
Abstract Background Metastatic head and neck cancers (HNCs) predominantly affect the lungs and have a two‐year overall survival (OS) of 15% to 50%, if amenable for pulmonary metastasectomy. Methods Retrospective review of the two‐year local control (LC), local‐regional control (LRC) within the same lobe, OS, and toxicity rates in consecutive patients with metastatic pulmonary HNC who underwent stereotactic ablative radiotherapy (SABR) January 2007 to May 2018. Results Evaluated 82 patients with 107 lung ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2020 - Wiley | Head & Neck
Robert M. Van Haren, Reza J. Mehran, Gabriel E. Mena, Arlene M. Correa, Mara B. Antonoff, Carla M. Baker, Ta Charra Woodard, Wayne L. Hofstetter, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh, David C. Rice,
BackgroundEnhanced recovery after surgery (ERAS) pathways aim to improve postoperative recovery through evidence-based practices, including early ambulation, multimodal opioid-sparing analgesia, and reduction of surgical stress. This study evaluated outcomes after implementation of ERAS in patients undergoing resection for pulmonary malignancy.MethodsA retrospective review compared outcomes for patients undergoing pulmonary resection for primary lung cancer. Analysis was performed between three periods: ...
Tópico(s): Gastric Cancer Management and Outcomes
2018 - Elsevier BV | The Annals of Thoracic Surgery
Jitesh B. Shewale, K. G. Mitchell, David B. Nelson, Anthony P. Conley, David C. Rice, Mara B. Antonoff, Wayne L. Hofstetter, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Reza J. Mehran, Ara A. Vaporciyan, Annikka Weissferdt, Boris Sepesi,
Background and Objectives Chest wall sarcomas are rare and may demonstrate heterogeneous features. Surgery remains the mainstay of treatment with chemotherapy and radiotherapy used as adjuncts. Herein, we report outcomes of a large cohort of patients with primary chest wall sarcoma who underwent resection. Methods Records of 121 patients who underwent resection for primary chest wall sarcoma between 1998 and 2013 were reviewed. A thoracic pathologist reexamined all tumors and categorized them according ...
Tópico(s): Ear and Head Tumors
2018 - Wiley | Journal of Surgical Oncology
David B. Nelson, David C. Rice, Jiangong Niu, Scott M. Atay, Ara A. Vaporciyan, Mara B. Antonoff, Wayne L. Hofstetter, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Anne S. Tsao, Daniel R. Gomez, Sharon H. Giordano, Reza J. Mehran, Boris Sepesi,
Purpose Small observational studies have shown a survival advantage to undergoing cancer-directed surgery for malignant pleural mesothelioma (MPM); however, it is unclear if these results are generalizable. Our purpose was to evaluate survival after treatment of MPM with cancer-directed surgery and to explore the effect surgery interaction with chemotherapy or radiation therapy on survival by using the National Cancer Database. Patients and Methods Patients with microscopically proven MPM were identified ...
Tópico(s): Medical Imaging and Pathology Studies
2017 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
David B. Nelson, David C. Rice, Jiangong Niu, Scott Atay, Ara A. Vaporciyan, Mara B. Antonoff, Wayne L. Hofstetter, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Anne S. Tsao, Daniel R. Gomez, Sharon H. Giordano, Reza J. Mehran, Boris Sepesi,
Malignant pleural mesothelioma is an aggressive and rare malignancy that frequently recurs despite aggressive therapy. We evaluated the frequency of treatment with surgery, radiation or chemotherapy, changes in therapy and survival over time and factors associated with the receipt of trimodality therapy. The National Cancer Database (NCDB) was used to query patients with histologically proven malignant pleural mesothelioma (2004–14). Treatment over time was evaluated using the Armitage trend test. ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2017 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
David B. Nelson, David C. Rice, K. G. Mitchell, Anne S. Tsao, Ara A. Vaporciyan, Mara B. Antonoff, Wayne L. Hofstetter, Garrett L. Walsh, Stephen G. Swisher, Jack A. Roth, Daniel R. Gomez, Reza J. Mehran, Boris Sepesi,
Multimodality therapy may prolong survival among resectable malignant pleural mesothelioma (MPM). However, the role of adjuvant radiation remains controversial. We explored a large nationwide database to determine whether adjuvant radiation is associated with improved survival.The National Cancer Database (NCDB) was queried to identify patients with MPM who received cancer-directed surgery between 2004-2013. Adjuvant radiation included intensity modulated radiation therapy or conformal 3D radiation. ...
Tópico(s): Pleural and Pulmonary Diseases
2019 - AME Publishing Company | Journal of Thoracic Disease
Mara B. Antonoff, William S. Ragalie, Arlene M. Correa, Jonathan Spicer, Boris Sepesi, Jack A. Roth, Garrett L. Walsh, Wayne L. Hofstetter, Stephen G. Swisher, David C. Rice, Ara A. Vaporciyan, Reza J. Mehran,
Tópico(s): Dysphagia Assessment and Management
2016 - Elsevier BV | The Annals of Thoracic Surgery
Erin M. Corsini, Annikka Weissferdt, Apar Pataer, Nicolas Zhou, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Ara A. Vaporciyan, Garrett L. Walsh, Tina Cascone, John V. Heymach, Stephen G. Swisher, Boris Sepesi,
Major pathological response (MPR) is prognostic of outcomes for patients with non-small-cell lung cancer following neoadjuvant chemotherapy and is used as the primary end point in neoadjuvant immunotherapy trials. We studied the influence of pathological nodal disease on patterns and timing of recurrence among patients with MPR.Patients treated with neoadjuvant chemotherapy for stages I-III non-small-cell lung cancer were identified. Surgical specimens were histopathologically examined for tumour ...
Tópico(s): Lung Cancer Research Studies
2020 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
Erin M. Corsini, K. G. Mitchell, Arlene M. Correa, Van K. Morris, Mara B. Antonoff, Nicolas Zhou, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh,
ObjectivesAlthough colorectal cancer bowel segment location has been shown to independently predict the outcomes in early stage disease, it has not been previously studied in the setting of pulmonary metastases. We sought to determine whether colorectal cancer location affects survival after pulmonary metastasectomy.MethodsPatients who had undergone pulmonary metastasectomy for colorectal cancer at a single institution from 2011 to 2018 were reviewed. Univariable and multivariable Cox regression ...
Tópico(s): Gastric Cancer Management and Outcomes
2020 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Erin M. Corsini, Wai Chin Foo, K. G. Mitchell, Nicolas Zhou, Dipen M. Maru, Jaffer A. Ajani, Wayne L. Hofstetter, Arlene M. Correa, Mara B. Antonoff, Steven H. Lin, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Boris Sepesi, Stephen G. Swisher, Ara A. Vaporciyan, Garrett L. Walsh,
Multiple investigations have shown inferior outcomes for esophageal cancer patients with signet ring cell (SRC) histology. Traditionally, SRC adenocarcinoma has been defined by ≥50% of the tumor composed of SRC. We hypothesized that patients with SRC even <50% would show resistance to standard multimodality therapy with poorer long-term outcomes.Patients treated with trimodality therapy for adenocarcinoma from 2006 to 2018 were evaluated for SRC on pretreatment biopsy specimens. Available hematoxylin ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2020 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Lorenzo Federico, Daniel J. McGrail, Salah-Eddine Bentebibel, Cara Haymaker, Angelo Ravelli, Marie‐Andrée Forget, Tatiana V. Karpinets, Peixin Jiang, Alexandre Reuben, Marcelo V. Negrão, J. Li, Roohussaba Khairullah, J. Zhang, Annika Weissferdt, Ara A. Vaporciyan, Mara B. Antonoff, G. Walsh, S.-Y. Lin, P. Andrew Futreal, Ignacio I. Wistuba, Jack A. Roth, Lauren A. Byers, Pierre-Olivier Gaudreau, Naohiro Uraoka, Alejandro Francisco‐Cruz, Hitoshi Dejima, Rossana Lazcano, Luisa M. Solis, Edwin R. Parra, J.J. Lee, Stephen G. Swisher, Tina Cascone, John V. Heymach, J. Zhang, Boris Sepesi, Don L. Gibbons, Chantale Bernatchez,
•Overall T-cell infiltration did not predict prognosis in localized NSCLC.•Analysis of high-dimensional TIL flow cytometry data identified two immunotypes predictive of patient outcomes.•Good prognosis subgroup was associated with T cells lacking inhibitory receptors and presence of tertiary lymphoid structures. BackgroundDespite the importance of tumor-infiltrating T lymphocytes (TILs) in cancer biology, the relationship between TIL phenotypes and their prognostic relevance for localized non-small- ...
Tópico(s): Immune Cell Function and Interaction
2021 - Elsevier BV | Annals of Oncology
Jitesh B. Shewale, Erin M. Corsini, Arlene M. Correa, Eric L. Brown, Luis León‐Novelo, Alan G. Nyitray, Mara B. Antonoff, Wayne L. Hofstetter, Reza J. Mehran, David C. Rice, Jack A. Roth, Garrett L. Walsh, Ara A. Vaporciyan, Stephen G. Swisher, Boris Sepesi,
The improvement in the management of lung cancer have the potential to improve survival in patients undergoing resection for early-stage (stage I and II) non-small cell lung cancer (NSCLC), but few studies have evaluated time trends and identified predictors of overall survival (OS).We identified surgically resected early-stage NSCLC between 1998 and 2016. The 3-year OS (1998-2014) and 5-year OS (1998-2012) rates were calculated for each year. Joinpoint regression was used to calculate annual percentage ...
Tópico(s): Esophageal Cancer Research and Treatment
2020 - Wiley | Journal of Surgical Oncology