Produção Nacional
Marcelo Callegari Zanetti, Jairo Osvaldo Cazetta, Dirceu Mattos, Sérgio Alves de Carvalho,
Com o objetivo de avaliar o efeito da presença do extrato pirolenhoso (EP) na calda de pulverização sobre o teor foliar de nutrientes de limoeiro 'Cravo' (Citrus limonia Osbeck), foi desenvolvido um experimento com seis tratamentos e quatro repetições, em blocos ao acaso, em ambiente protegido. Os tratamentos constituíram da pulverização das soluções: T0 = água; T1 = solução de micronutrientes sem EP; T2 = solução de micronutrientes + EP (1cm³ dm-3); T3 = solução de micronutrientes + EP (2 cm³ dm-3); T4 = solução ...
Tópico(s): Horticultural and Viticultural Research
2004 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
Produção Nacional
Marcelo Callegari Zanetti, Jairo Osvaldo Cazetta, Dirceu Mattos, Sérgio Alves de Carvalho,
O trabalho teve como objetivo avaliar o efeito do uso de fino de carvão no substrato e da aplicação de extrato pirolenhoso no substrato e na planta sobre o desenvolvimento de porta-enxertos de limoeiro 'Cravo' (Citrus limonia Osbeck) cultivados em ambiente protegido. O experimento foi desenvolvido no delineamento em blocos casualisados, com análise em esquema fatorial 3 x 2 x 3, sendo: 3 proporções de fino de carvão (0, 100 e 200 cm³ dm-3) em mistura com substrato comercial, 2 concentrações de extrato ...
Tópico(s): Plant Physiology and Cultivation Studies
2003 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
Produção Nacional
Revisado por pares
John Jairo Ramírez, Carlos Eduardo de Mattos Bicudo,
Spatial and temporal variation of climatic and physical characteristics in a shallow tropical reservoir in the city of São Paulo, Southeastern Brazil, and their possible influence on the dynamics of the phytoplankton population. Samples were taken at 5 depths of the water column (subsurface: 1% Io, 10% Io, 2 m, and bottom) and at 4 hour intervals (6:00, 10:00, 14:00, 18:00, 22:00, 2:00, and 6:00 h) during summer (March 3-4), fall (June 13-14), winter (August 29-30), and spring (November 29-30) of 1994 ...
Tópico(s): Fish biology, ecology, and behavior
2002 - Instituto Internacional de Ecologia (Brazil) | Brazilian Journal of Biology
Produção Nacional
Revisado por pares
John Jairo Ramírez, Carlos Eduardo de Mattos Bicudo,
The vertical and diurnal variation of nitrogen and phosphorus forms, as well as that of soluble reactive silica (SRS), were studied in four sampling days at Garças reservoir, a shallow tropical one located in the city of São Paulo, in southeastern Brazil. Except for N-NH4, all other inorganic forms of nitrogen (N-NO2, N-NO3, and total N) demonstrated decreased concentrations toward the bottom of reservoir. Similarly, all showed significant diurnal differences on every sampling day, with increased ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2005 - Instituto Internacional de Ecologia (Brazil) | Brazilian Journal of Biology
Produção Nacional
Revisado por pares
José D. Debes, Aaron J. Chan, Domingo Balderramo, Luciana Kikuchi, Esteban González Ballerga, Jhon Prieto, Mónica Tapias, Víctor Idrovo, Milagros B. Davalos, Fernando Cairo, Fernando J. Barreyro, Sebastián Paredes, Nelia Hernández, Karla Avendaño, Javier Díaz Ferrer, Ju Dong Yang, Enrique Carrera, Jairo A. Garcia, Ângelo Zambam de Mattos, Bruno Salomão Hirsch, Pablo T. Gonçalves, Flair José Carrilho, Lewis R. Roberts,
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Most studies addressing the epidemiology of HCC originate from developed countries. This study reports the preliminary findings of a multinational approach to characterize HCC in South America.We evaluated 1336 HCC patients seen at 14 centres in six South American countries using a retrospective study design with participating centres completing a template chart of patient characteristics. The diagnosis ...
Tópico(s): Hepatitis B Virus Studies
2017 - Wiley | Liver International
Produção Nacional
João Marcos Lima, Alexandre Kolodynskie Guetter, Saulo R. Freitas, Jairo Panetta, João Gerd Zell de Mattos,
Tópico(s): Wind Energy Research and Development
2017 - Springer Science+Business Media | Journal of Control Automation and Electrical Systems
Produção Nacional
Revisado por pares
Adriana Cosentino Garcia Miguel, Fernanda Cristina Silva, Gilson da Silva, Jairo Sciamareli, Elizabeth da Costa Mattos,
Abstract This paper is a review about the types of bonding agents used in propellants, as well as the main polymeric matrices used in thermal insulation applied in the rocket engines studied throughout the last decades. This paper aims to show the importance both of the bonding agents in the composition of the propellant and of the thermal insulation coating the rocket engine, which is in contact with the propellant grain. This paper also shows many researchers have been applied, in different spectral ...
Tópico(s): Thermal and Kinetic Analysis
2020 - Wiley | Propellants Explosives Pyrotechnics
Produção Nacional
Revisado por pares
Ígor Médici de Mattos, Jairo de Souza, Ademilson Espencer Egea Soares,
Today, more than 1500 tons of bee pollen are produced per year worldwide. Despite the importance of this niche within the apiculture industry, several aspects of the bee pollen production system have been poorly studied. The most suitable population size for productive colonies, as well as the efficacy of carbohydrate and protein supplementation, has raised many questions and divergent conclusions are drawn in the literature. This research attempts to elucidate some questions of the bee pollen production ...
Tópico(s): Bee Products Chemical Analysis
2015 - Taylor & Francis | Journal of Apicultural Research
Amaranto Suárez Mattos, Jairo Aguilera, Édgar Salguero, Carolina Wiesner,
Antecedentes: En los países de bajos ingresos un niño diagnosticado con cáncer tiene un 80% de probabilidad de morir mientras que en los países de ingresos altos más del 80% sobrevive a la enfermedad. En Colombia, un país de ingresos medios, el gobierno expidió una nueva legislación que promueve la generación de unidades de atención integral; sin embargo, siete años después de su expedición, ninguna Institución ha sido reconocida como tal por el Ministerio de Salud.Objetivo: Caracterizar la actual ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - University of Valle | Colombia medica
Produção Nacional
Revisado por pares
Otávio Augusto Chaves, Natália Fintelman-Rodrigues, Xuanting Wang, Carolina Q. Sacramento, Jairo R. Temerozo, André C. Ferreira, Mayara Mattos, Filipe S. Pereira‐Dutra, Patrı́cia T. Bozza, Hugo C. Castro‐Faria‐Neto, James J. Russo, Jingyue Ju, Thiago Moreno L. Souza,
Despite the fast development of vaccines, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still circulating and generating variants of concern (VoC) that escape the humoral immune response. In this context, the search for anti-SARS-CoV-2 compounds is still essential. A class of natural polyphenols known as flavonoids, frequently available in fruits and vegetables, is widely explored in the treatment of different diseases and used as a scaffold for the design of novel drugs. Therefore, ...
Tópico(s): Pharmacological Effects of Natural Compounds
2022 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Silvia Fortunato de Cano, Manuel Cano, J. Ribamar Costa, Jairo Alves Pinheiro, Rodrigo Bellio de Mattos Barretto, David Costa de Souza Le Bihan, Alexandre Abizaid, Amanda Sousa, J. Eduardo Sousa,
Background Alcohol septal ablation (ASA) is an alternative treatment for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients refractory to pharmacological therapy. We sought to evaluate the immediate and long‐term incidence of death and changes in life quality in a consecutive cohort submitted to ASA. Methods and Results Between October 1998 and December 2013, a total of 56 patients (mean age 53.2 ± 15.5) with symptomatic refractory HOCM were treated with ASA and followed during 15 years ( ...
Tópico(s): Cardiovascular Effects of Exercise
2016 - Wiley | Catheterization and Cardiovascular Interventions
Produção Nacional
Revisado por pares
Suzana Herculano‐Houzel, Kamilla Avelino-de-Souza, Kleber Neves, Jairo PorfÃrio, Débora J. Messeder, Larissa Mattos FeijÃ, J. Maldonado, Paul R. Manger,
What explains the superior cognitive abilities of the human brain compared to other, larger brains? Here we investigate the possibility that the human brain has a larger number of neurons than even larger brains by determining the cellular composition of the brain of the African elephant. We find that the African elephant brain, which is about three times larger than the human brain, contains 257 billion (10(9)) neurons, three times more than the average human brain; however, 97.5% of the neurons ...
Tópico(s): Primate Behavior and Ecology
2014 - Frontiers Media | Frontiers in Neuroanatomy
Produção Nacional
Revisado por pares
Otávio Augusto Chaves, Carolina Q. Sacramento, André C. Ferreira, Mayara Mattos, Natália Fintelman-Rodrigues, Jairo R. Temerozo, Leonardo Vázquez, Douglas Pereira Pinto, Gabriel Parreiras Estolano da Silveira, Laís Bastos da Fonseca, Heliana Martins Pereira, Aluana Santana Carlos, Joana C. d’Avila, João P. B. Viola, Robson Q. Monteiro, Patrı́cia T. Bozza, Hugo C. Castro‐Faria‐Neto, Thiago Moreno L. Souza,
Atazanavir (ATV) has already been considered as a potential repurposing drug to 2019 coronavirus disease (COVID-19); however, there are controversial reports on its mechanism of action and effectiveness as anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Through the pre-clinical chain of experiments: enzymatic, molecular docking, cell-based and in vivo assays, it is demonstrated here that both SARS-CoV-2 B.1 lineage and variant of concern gamma are susceptible to this antiretroviral. ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Produção Nacional
Revisado por pares
Lívia Teixeira, Jairo R. Temerozo, Filipe S. Pereira‐Dutra, André C. Ferreira, Mayara Mattos, Barbara Simonson Gonçalves, Carolina Q. Sacramento, Lohanna Palhinha, Tamires Cunha‐Fernandes, Suelen da Silva Gomes Dias, Vinícius Cardoso Soares, Ester A. Barreto, Daniella Cesar-Silva, Natália Fintelman-Rodrigues, Camila R. R. Pão, Caroline S. de Freitas, Patrícia A. Reis, Eugênio D. Hottz, Fernando A. Bozza, Dumith Chequer Bou‐Habib, Elvira M. Saraiva, Cecília J. G. de Almeida, João P. B. Viola, Thiago Moreno L. Souza, Patrı́cia T. Bozza,
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical studies, statins have been identified as beneficial to hospitalized patients with COVID-19. However, experimental evidence of underlying statins protection against SARS-CoV-2 remains elusive. Here we reported for the first-time experimental evidence of the protective effects of simvastatin treatment both in vitro and in vivo . We found ...
Tópico(s): Inflammasome and immune disorders
2022 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Áislan de Carvalho Vivarini, Renata M. Pereira, Victor Barreto‐de‐Souza, Jairo R. Temerozo, Deivid Costa Soares, Elvira M. Saraiva, Alessandra Mattos Saliba, Dumith Chequer Bou‐Habib, Ulisses Gazos Lopes,
Abstract HIV-1 co-infection with human parasitic diseases is a growing public health problem worldwide. Leishmania parasites infect and replicate inside macrophages, thereby subverting host signaling pathways, including the response mediated by PKR. The HIV-1 Tat protein interacts with PKR and plays a pivotal role in HIV-1 replication. This study shows that Tat increases both the expression and activation of PKR in Leishmania -infected macrophages. Importantly, the positive effect of Tat addition ...
Tópico(s): RNA regulation and disease
2015 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Thiago Moreno L. Souza, Vagner D. Pinho, Cristina F. Setim, Carolina Q. Sacramento, Rodrigo Marcon, Natália Fintelman-Rodrigues, Otávio Augusto Chaves, Melina Heller, Jairo R. Temerozo, André C. Ferreira, Mayara Mattos, Patrícia B. Momo, Suelen da Silva Gomes Dias, João Silveira Moledo Gesto, Filipe S. Pereira‐Dutra, João P. B. Viola, Celso Martins Queiroz‐Junior, Lays Cordeiro Guimarães, Ian Meira Chaves, Pedro Pires Goulart Guimarães, Vivian Vasconcelos Costa, Mauro Martins Teixeira, Dumith Chequer Bou‐Habib, Patrı́cia T. Bozza, Anderson R. Aguillón, Jarbas Siqueira-Junior, Sergio Macedo-Junior, Edineia L. Andrade, Guilherme Pasetto Fadanni, Sara Emília Lima Tolouei, Francine B. Potrich, Adara A. Santos, Naiani F. Marques, João Β. Calixto, Jaime A. Rabi,
Orally available antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary because of the continuous circulation of new variants that challenge immunized individuals. Because severe COVID-19 is a virus-triggered immune and inflammatory dysfunction, molecules endowed with both antiviral and anti-inflammatory activity are highly desirable. We identified here that kinetin (MB-905) inhibits the in vitro replication of SARS-CoV-2 in human hepatic and pulmonary cell lines. ...
Tópico(s): Mosquito-borne diseases and control
2023 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
André C. Ferreira, Vinícius Cardoso Soares, Isaclaudia G. Azevedo-Quintanilha, Suelen da Silva Gomes Dias, Natália Fintelman-Rodrigues, Carolina Q. Sacramento, Mayara Mattos, Caroline S. de Freitas, Jairo R. Temerozo, Lívia Teixeira, Eugênio D. Hottz, Ester A. Barreto, Camila R. R. Pão, Lohanna Palhinha, Milene Dias Miranda, Dumith Chequer Bou‐Habib, Fernando A. Bozza, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
The original version of this article unfortunately contained a mistake. The authors noticed an accidental duplication of Fig. 1E. The correct figure can be found below. The original article has been corrected. © 2021 The Author(s).
Tópico(s): Dermatological and COVID-19 studies
2021 - Springer Nature | Cell Death Discovery
Produção Nacional
Revisado por pares
André C. Ferreira, Vinícius Cardoso Soares, Isaclaudia G. Azevedo-Quintanilha, Suelen da Silva Gomes Dias, Natália Fintelman-Rodrigues, Carolina Q. Sacramento, Mayara Mattos, Caroline S. de Freitas, Jairo R. Temerozo, Lívia Teixeira, Eugênio D. Hottz, Ester A. Barreto, Camila R. R. Pão, Lohanna Palhinha, Milene Dias Miranda, Dumith Chequer Bou‐Habib, Fernando A. Bozza, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Springer Nature | Cell Death Discovery
Produção Nacional
Revisado por pares
Suelen da Silva Gomes Dias, Vinícius Cardoso Soares, André C. Ferreira, Carolina Q. Sacramento, Natália Fintelman-Rodrigues, Jairo R. Temerozo, Lívia Teixeira, Marcos Alexandre Nunes da Silva, Ester A. Barreto, Mayara Mattos, Caroline S. de Freitas, Isaclaudia G. Azevedo-Quintanilha, Pedro Paulo de Abreu Manso, Milene Dias Miranda, Marilda Mendonça Siqueira, Eugênio D. Hottz, Camila R. R. Pão, Dumith Chequer Bou‐Habib, Débora Ferreira Barreto-Vieira, Fernando A. Bozza, Thiago Moreno L. Souza, Patrı́cia T. Bozza,
Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus replication may lead to potential targets for therapeutic intervention. The mechanisms and pathways explored by SARS-CoV-2 to support its replication within host cells are not fully known. Lipid droplets (LD) are organelles with major functions in lipid metabolism, energy homeostasis and intracellular transport, ...
Tópico(s): Lipid Membrane Structure and Behavior
2020 - Public Library of Science | PLoS Pathogens
Produção Nacional
Revisado por pares
Bruno Bolognesi, Rodrigo Rossi Horochovski, Ivan Jairo Junckes, Karolina Mattos Roeder,
Objective/Context: In advanced democracies, political parties distribute their resources internally to make themselves stronger. Few studies examine the role of parties as intermediaries between campaign resources and candidates. Hence, we examine how political parties assigned campaign resources in 2014 election for federal deputies. Methodology: We tested the following hypothesis: resources from parties will be distributed to favor candidates holding office, at the expense of the party’s organizational ...
Tópico(s): Youth, Politics, and Society
2020 - Universidad de Los Andes | Colombia Internacional
Jairo Roberto Jiménez Rueda, José Ernesto Sacchi Pessotti, Juércio Tavares de Mattos,
This paper studies the applicability of a model to the evolutive dynamics of Pantanal physiography. The Miranda-Aquidauana Pantanal has developed as a pre-existent fluvial plain in the beginning, from Paraguay river, whose ancient marks, recognized by weathering alteration volumes, show components that make possible its relative age determination and consequently permit the com- prehension of the ancient and recent dynamic evolutions, that are responsible for the present physi- ographic form.
Tópico(s): Fish biology, ecology, and behavior
1998 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Loacyr Claudio Martins Fernandes, Marcilon Bezerra Da Silva,
... o qual foi desenvolvido na Escola Municipal Juiz Jairo de Mattos, situada no município de Vila Velha/ES. O ...
Tópico(s): Physical Education and Gymnastics
2023 - Brazilian Journal of Development | Brazilian Journal of Health Review
Produção Nacional
Tomoyuki Ohara, Jairo Roberto Jiménez-Rueda, Juércio Tavares de Mattos, Norton Roberto Caetano,
This study describes the procedure used to identify zones considered to be homogeneous on the basis of the physical characteristics of the terrain interpreted on Landsat TM images. The study was carried out on the upper-middle Paraiba do Sul river region, State of Sao Paulo, Brazil, and took into account the main characteristics of the physical environment (geology, physical geography and soils). The study took into account data from laboratory analysis of soils and rocks in reference to their physical, ...
Tópico(s): Geochemistry and Geologic Mapping
2003 - Sociedade Brasileira de Geologia | Brazilian Journal of Geology
Produção Nacional
Revisado por pares
Carolina Q. Sacramento, Natália Fintelman-Rodrigues, Suelen da Silva Gomes Dias, Jairo R. Temerozo, Aline de Paula Dias da Silva, Carine S. da Silva, C. Fernández Blanco, André C. Ferreira, Mayara Mattos, Vinícius Cardoso Soares, Filipe S. Pereira‐Dutra, Milene Dias Miranda, Débora Ferreira Barreto-Vieira, Marcos Alexandre Nunes da Silva, Suzana de Siqueira Santos, Mateo Torres, Otávio Augusto Chaves, Rajith K. R. Rajoli, Alberto Paccanaro, Andrew Owen, Dumith Chequer Bou‐Habib, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
Despite the development of specific therapies against severe acute respiratory coronavirus 2 (SARS-CoV-2), the continuous investigation of the mechanism of action of clinically approved drugs could provide new information on the druggable steps of virus–host interaction. For example, chloroquine (CQ)/hydroxychloroquine (HCQ) lacks in vitro activity against SARS-CoV-2 in TMPRSS2-expressing cells, such as human pneumocyte cell line Calu-3, and likewise, failed to show clinical benefit in the Solidarity ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2022 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Darci Corter Pires, Aparecida M. Kawamoto, Jairo Sciamareli, Elizabeth da Costa Mattos, Milton Faria Diniz, Rita de Cássia Lazzarini Dutra, Koshun Iha,
A new method using wet chemistry and instrumental analysis has been developed for evaluating the ring-opening of aziridine tris [1-(2 methyl) aziridinyl] phosphide oxide (MAPO) of the bonding agent used in composite propellant. A reduction was observed in the intensity absorption bands in 1400 and 1040 cmˉ ¹ , characteristic of aziridinic ring. It was also observed, in some cases, that when the number of open aziridinyl ring increases, the NH band in the range 3400-3300 cmˉ ¹ , that appears with ring- ...
Tópico(s): Thermal and Kinetic Analysis
2009 - Aerospace Technology and Science Department | Journal of Aerospace Technology and Management
Produção Nacional
Revisado por pares
Carolina Q. Sacramento, Natália Fintelman-Rodrigues, Jairo R. Temerozo, Aline de Paula Dias da Silva, Suelen da Silva Gomes Dias, Carine dos Santos da Silva, André C. Ferreira, Mayara Mattos, Camila R. R. Pão, Caroline S. de Freitas, Vinícius Cardoso Soares, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes, Frederico Silva Castelo Branco, Mônica M. Bastos, Núbia Boechat, Felipe Saraiva, Marcelo Alves Ferreira, Steffen Jockusch, Xuanting Wang, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Aitor Garzia, Thomas Tuschl, James J. Russo, Rajith K. R. Rajoli, Carolina Pedrosa, Gabriela Vitória, Letícia R. Q. Souza, Livia Goto‐Silva, Marília Zaluar P. Guimarães, Stevens K. Rehen, Andrew Owen, Fernando A. Bozza, Dumith Chequer Bou‐Habib, Jingyue Ju, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
Abstract Background Current approaches of drug repurposing against COVID-19 have not proven overwhelmingly successful and the SARS-CoV-2 pandemic continues to cause major global mortality. SARS-CoV-2 nsp12, its RNA polymerase, shares homology in the nucleotide uptake channel with the HCV orthologue enzyme NS5B. Besides, HCV enzyme NS5A has pleiotropic activities, such as RNA binding, that are shared with various SARS-CoV-2 proteins. Thus, anti-HCV NS5B and NS5A inhibitors, like sofosbuvir and daclatasvir, ...
Tópico(s): Hepatitis C virus research
2021 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Produção Nacional
Revisado por pares
Ana Cláudia dos Santos Pereira Andrade, Gabriel Henrique Campolina-Silva, Celso Martins Queiroz‐Junior, Leonardo Camilo de Oliveira, Larisse de Souza Barbosa Lacerda, Jordane Clarisse Pimenta, Filipe Resende, Ian de Meira Chaves, Ingredy Passos, Danielle Cunha Teixeira, Paloma Graziele Bittencourt‐Silva, Priscila Aparecida Costa Valadão, Leonardo Rossi-Oliveira, Maísa Mota Antunes, André Felipe Almeida Figueiredo, Natália Teixeira Wnuk, Jairo R. Temerozo, André C. Ferreira, Allysson Cramer, Cleida A. Oliveira, Ricardo Durães‐Carvalho, Clarice Weis Arns, Pedro Pires Goulart Guimarães, Guilherme Mattos Jardim Costa, Gustavo Batista Menezes, Cristina Guatimosim, Glauber S. F. da Silva, Thiago Moreno L. Souza, Breno Rocha Barrioni, Marivalda M. Pereira, Lirlândia P. Sousa, Mauro Martins Teixeira, Vivian Vasconcelos Costa,
The emergence of life-threatening zoonotic diseases caused by betacoronaviruses, including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted the need for developing preclinical models mirroring respiratory and systemic pathophysiological manifestations seen in infected humans. Here, we showed that C57BL/6J wild-type mice intranasally inoculated with the murine betacoronavirus murine hepatitis coronavirus 3 (MHV-3) develop a robust inflammatory response leading to acute lung injuries, ...
Tópico(s): Animal Virus Infections Studies
2021 - American Society for Microbiology | Journal of Virology
Produção Nacional
Cristiane Alessandra de Moura, Juércio Tavares de Mattos, Jairo Roberto Jiménez-Rueda,
Analysis of fracturing to determine areas of instability in the strip of intervention of the Osvat/Osplan pipeline in São Sebastião, state of São Paulo. The present work aimed at characterizing geological features that identify areas with high ruptibility (fracturing) in the Osvat/Osplan pipeline in São Sebastião, São Paulo. The analysis of ruptile geological structures (lines of strikes and structural lineaments) through the use of orbital remote sensing was used as systematic mapping. The analysis ...
Tópico(s): Geochemistry and Geologic Mapping
2012 - Sociedade Brasileira de Geologia | Revista Brasileira de Geociências
Produção Nacional
Revisado por pares
Jairo R. Temerozo, Carolina Q. Sacramento, Natália Fintelman-Rodrigues, Camila R. R. Pão, Caroline S. de Freitas, Suelen da Silva Gomes Dias, André C. Ferreira, Mayara Mattos, Vinícius Cardoso Soares, Lívia Teixeira, Isaclaudia G. Azevedo-Quintanilha, Eugênio D. Hottz, Pedro Kurtz, Fernando A. Bozza, Patrı́cia T. Bozza, Thiago Moreno L. Souza, Dumith Chequer Bou‐Habib,
Abstract Infection by SARS-CoV-2 may elicit uncontrolled and damaging inflammatory responses. Thus, it is critical to identify compounds able to inhibit virus replication and thwart the inflammatory reaction. Here, we show that the plasma levels of the immunoregulatory neuropeptide VIP are elevated in patients with severe COVID-19, correlating with reduced inflammatory mediators and with survival on those patients. In vitro, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating ...
Tópico(s): Stress Responses and Cortisol
2022 - Oxford University Press | Journal of Leukocyte Biology
Produção Nacional
Revisado por pares
Natália Fintelman-Rodrigues, Carolina Q. Sacramento, Carlyle Ribeiro Lima, Franklin Souza‐Silva, André C. Ferreira, Mayara Mattos, Caroline S. de Freitas, Vinícius Cardoso Soares, Suelen da Silva Gomes Dias, Jairo R. Temerozo, Milene Dias Miranda, Aline da Rocha Matos, Fernando A. Bozza, Nicolas Carels, Carlos Roberto Alves, Marilda Mendonça Siqueira, Patrı́cia T. Bozza, Thiago Moreno L. Souza,
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is already responsible for far more deaths than previous pathogenic coronaviruses (CoVs) from 2002 and 2012. The identification of clinically approved drugs to be repurposed to combat 2019 CoV disease (COVID-19) would allow the rapid implementation of potentially life-saving procedures. The major protease (Mpro) of SARS-CoV-2 is considered a promising target, based on previous results from related CoVs with lopinavir (LPV), an HIV protease ...
Tópico(s): Mosquito-borne diseases and control
2020 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy