Jake Alan Pitt, Julio R. Banga,
Dynamic modelling is a core element in the systems biology approach to understanding complex biosystems. Here, we consider the problem of parameter estimation in models of biological oscillators described by deterministic nonlinear differential equations. These problems can be extremely challenging due to several common pitfalls: (i) a lack of prior knowledge about parameters (i.e. massive search spaces), (ii) convergence to local optima (due to multimodality of the cost function), (iii) overfitting ( ...
Tópico(s): Protein Structure and Dynamics
2019 - BioMed Central | BMC Bioinformatics
Kumyul S. Albone, Jake MacMillan, Andrew R. Pitt, Christine L. Willis,
Full assignments of the 1H-nmr chemical shifts of the ring A protons in gibberellin A20 methyl ester 13-acetate have been made on the basis of 1H-, 2H- and 13C-nmr data of various deuteriated derivatives. These assignments have been used to prove that catalytic deuteriogenation of GA5-16, 17- epoxide-13-acetate is a syn-addition from the less hindered β-face accompanied by allylic exchange at C-1 giving isotopic labels at the 1β-, 2β- and 3β- positions. The position and stereochemistry of isotopic ...
Tópico(s): Steroid Chemistry and Biochemistry
1986 - Elsevier BV | Tetrahedron
Margaret J. Pitts, Jake Harwood,
This Epilogue briefly reviews some themes present in this collection, and highlights its many contributions. We then look beyond the contributions of the Special Issue papers to consider the continued conceptual development of communication accommodation theory. We argue for re-conceptualizing CAT as a theory of competence, suggesting that accommodation competence is a developmental phenomenon built on the accumulation of accommodation resources and repertoires over the lifespan. We address contexts ...
Tópico(s): Aging and Gerontology Research
2014 - Elsevier BV | Language & Communication
Hannah E. Segaloff, Devlin Cole, Hannah G. Rosenblum, Christine C. Lee, Clint N. Morgan, Patrick Remington, Collin Pitts, Patrick Kelly, Jake Baggott, Allen C. Bateman, Tarah Somers, Jeanne C. Ruff, David Payne, Rodel Desamu-Thorpe, Monique A. Foster, Dustin W. Currie, Glen R. Abedi, Ryan P. Westergaard, Christopher H. Hsu, J. E. Tate, Hannah L. Kirking,
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks occurred at universities during Fall 2020, but little is known about risk factors for campus-associated infections or immunity provided by anti-SARS-CoV-2 antibodies in young adults.
Tópico(s): COVID-19 epidemiological studies
2021 - Oxford University Press | Open Forum Infectious Diseases
Argyro Tsipa, Jake Alan Pitt, Julio R. Banga, Athanasios Mantalaris,
Data integration to model-based description of biological systems incorporating gene dynamics improves the performance of microbial systems. Bioprocess performance, typically predicted using empirical Monod-type models, is essential for a sustainable bioeconomy. To replace empirical models, we updated a hybrid gene regulatory network-growth kinetic model, predicting aromatic pollutants degradation and biomass growth in Pseudomonas putida mt-2. We modeled a complex biological system including extensive ...
Tópico(s): Computational Drug Discovery Methods
2020 - Springer Science+Business Media | Bioprocess and Biosystems Engineering
Quan Liu, Gaelen K. Dwyer, Yifei Zhao, Huihua Li, Lisa Mathews, Anish Bhaswanth Chakka, Uma Chandran, Jake Demetris, John F. Alcorn, Keven M. Robinson, Luis A. Ortiz, Bruce R. Pitt, Angus W. Thomson, Ming-Hui Fan, Timothy R. Billiar, Hēth Turnquist,
Acute respiratory distress syndrome is an often fatal disease that develops after acute lung injury and trauma. How released tissue damage signals, or alarmins, orchestrate early inflammatory events is poorly understood. Herein we reveal that IL-33, an alarmin sequestered in the lung epithelium, is required to limit inflammation after injury due to an unappreciated capacity to mediate Foxp3+ Treg control of local cytokines and myeloid populations. Specifically, Il33-/- mice are more susceptible ...
Tópico(s): Asthma and respiratory diseases
2019 - American Society for Clinical Investigation | JCI Insight
M. Almond, Hugo Farne, Millie M. Jackson, Akhilesh Jha, Orestis Katsoulis, Oliver Pitts, Tanushree Tunstall, Eteri Regis, Jake Dunning, Adam J. Byrne, Patrick Mallia, Onn Min Kon, Ken Saunders, Karen D. Simpson, Robert J. Snelgrove, Peter Openshaw, Michael R. Edwards, William Barclay, Liam M. Heaney, Sebastian L. Johnston, Aran Singanayagam,
Abstract Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify that obese individuals have deficient pulmonary antiviral immune responses in bronchoalveolar lavage cells but not in bronchial epithelial cells or peripheral blood dendritic cells. We show that the obese human airway metabolome is perturbed with associated increases in the airway concentrations of the adipokine leptin which correlated ...
Tópico(s): Respiratory viral infections research
2023 - Nature Portfolio | Nature Communications
R. Amanda Cooper, Margaret J. Pitts, Jake Harwood,
Abstract This study investigated the relational turning points experienced by caregiving spouses across the trajectory of Alzheimer's disease and related dementias. Data were collected using a modified version of the retrospective interviewing technique which facilitated close analysis of relational turning points and the role of communication in shaping and managing these turning points. Caregiving spouses described nine relational turning points across the disease trajectory. The turning points ...
Tópico(s): Dementia and Cognitive Impairment Research
2021 - Wiley | Personal Relationships
Nancy A. Niemuth, Dawn M. Fallacara, Cheryl A. Triplett, Sanjay Tamrakar, Alisha Rajbhandari, Clint Florence, Lucy Ward, Anthony Griffiths, Ricardo E. Carrión, Yenny Goez-Gazi, Kendra J. Alfson, Hilary Staples, Trevor Brasel, Jason E. Comer, Shane Massey, Jeanon Smith, Andrew Kocsis, Jake E. Lowry, Sara C. Johnston, Ayşegül Nalça, Arthur J. Goff, Amy C. Shurtleff, M. Louise M. Pitt, John C. Trefry, Michael P. Fay,
Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus ) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medical countermeasures against Ebola virus (EBOV) will require testing under the FDA Animal Rule. Multiple vaccine candidates have been evaluated using cynomolgus monkeys (CM) exposed to EBOV Kikwit strain. To the best of our knowledge, however, animal model development ...
Tópico(s): Hepatitis B Virus Studies
2021 - Public Library of Science | PLoS ONE
Oscar Imventarza, S Todo, G Eiras, Yutaka Ueda, Hiroshi Furukawa, Wu Ym, Yihong Zhu, A. Oks, Jake Demetris, Starzl Te,
FK 506 was tested in unrelated baboons submitted to renal transplantation and bilateral native nephrectomy. Untreated baboons died after 9.2 ± 4.0 SD days. When FK 506 was given orally for 90 days, survival with the optimum dose was 74.6 ± 28.9 days; this allowed maximum credit for each individual animal of 90 days. A 3-day course of intramuscular FK 506 started on postoperative day 4 allowed 1- to 2-month survival. Delayed rejection in these baboons as well as in those treated daily for 90 days with ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
1990 - Elsevier BV | Transplantation Proceedings
Dustin W. Currie, Gage K. Moreno, Miranda J. Delahoy, Ian W. Pray, Amanda Jovaag, Katarina M. Braun, Devlin Cole, Todd Shechter, Geroncio Fajardo, Carol Griggs, Brian S. Yandell, Steve Goldstein, Dena Bushman, Hannah E. Segaloff, G. Patrick Kelly, Collin Pitts, Christine U. Lee, Katarina M. Grande, Amanda Kita-Yarbro, Brittany Grogan, Sara Mader, Jake Baggott, Allen C. Bateman, Ryan P. Westergaard, Jacqueline E. Tate, Thomas C. Friedrich, Hannah L. Kirking, David H. O’Connor, Marie E. Killerby,
University settings have demonstrated potential for coronavirus disease (COVID-19) outbreaks; they combine congregate living, substantial social activity, and a young population predisposed to mild illness. Using genomic and epidemiologic data, we describe a COVID-19 outbreak at the University of Wisconsin-Madison, Madison, Wisconsin, USA. During August-October 2020, a total of 3,485 students, including 856/6,162 students living in dormitories, tested positive. Case counts began rising during move- ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Centers for Disease Control and Prevention | Emerging infectious diseases
Jake Alan Pitt, Lucian Gomoescu, Constantinos C. Pantelides, Benoît Chachuat, Julio R. Banga,
Many biological systems exhibit oscillations in relation to key physiological or cellular functions, such as circadian rhythms, mitosis and DNA synthesis. Mathematical modelling provides a powerful approach to analysing these biosystems. Applying parameter estimation methods to calibrate these models can prove a very challenging task in practice, due to the presence of local solutions, lack of identifiability, and risk of overfitting. This paper presents a comparison of three state-of-the-art methods: ...
Tópico(s): Control Systems and Identification
2018 - Elsevier BV | IFAC-PapersOnLine
P.C. Stangeby, X. Bonnin, J.M. Canik, David Elder, B. Lomanowski, J. Lore, Adam McLean, Jake Nichols, R.A. Pitts, E.A. Unterberg,
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2021 - Cambridge University Press | Bulletin of the American Physical Society
... s Harlem Renaissance Party (2015), and Sharifa Rhodes-Pitts's Jake Makes a World (2015) to discuss the ways ...
Tópico(s): Spatial and Cultural Studies
2023 - International Research Society for Children's Literature | International Research in Children s Literature
Mark R. Davies, Nadia Keller, Stephan Brouwer, Magnus G. Jespersen, Amanda J. Cork, Andrew J. Hayes, Miranda E. Pitt, David M. P. De Oliveira, Nichaela Harbison-Price, Olivia M. Bertolla, Daniel G. Mediati, Bodie F. Curren, George Taiaroa, Jake A. Lacey, Helen Smith, Ning-Xia Fang, Lachlan Coin, Kerrie Stevens, Steven Y. C. Tong, Martina L. Sanderson‐Smith, Jai J. Tree, Adam Irwin, Keith Grimwood, Benjamin P. Howden, Amy V. Jennison, Mark J. Walker,
A new variant of Streptococcus pyogenes serotype M1 (designated 'M1UK') has been reported in the United Kingdom, linked with seasonal scarlet fever surges, marked increase in invasive infections, and exhibiting enhanced expression of the superantigen SpeA. The progenitor S. pyogenes 'M1global' and M1UK clones can be differentiated by 27 SNPs and 4 indels, yet the mechanism for speA upregulation is unknown. Here we investigate the previously unappreciated expansion of M1UK in Australia, now isolated ...
Tópico(s): Neonatal and Maternal Infections
2023 - Nature Portfolio | Nature Communications
Kumyul S. Albone, Jake MacMillan, Andrew R. Pitt, Christine L. Willis,
Abstract Full assignments of the 1 H NMR chemical shifts of the ring A protons in gibberellin A20 methyl ester 13‐acetate (Ia) have been made on the basis of 1 H, 2H, and 13 C NMR data for various deuterated derivatives (Ib)‐(Ig) and hydrolysis products (II) thereof.
Tópico(s): Fungal Biology and Applications
1986 - Wiley | Chemischer Informationsdienst
Margaret J. Pitts, Jake Harwood,
This introductory essay outlines the rationale for this special issue. It reports on the background to the International Conferences on Language and Social Psychology (ICLASPs) and establishes the importance of a special issue representing the work from ICLASP11, held in Tucson, Arizona, in the summer of 2008. After describing the keynote presentations at the conference, specific articles making up the special issue are introduced. Finally, the future of the conferences is addressed with the announcement ...
Tópico(s): Second Language Learning and Teaching
2009 - SAGE Publishing | Journal of Language and Social Psychology
Jessica Blunden, Derek S. Arndt, Kate M. Willett, A. J. Dolman, D. F. Hurst, Jared Rennie, Peter Thorne, Markus G. Donat, Robert Dunn, Craig S. Long, John R. Christy, Jeannette Noetzli, Hanne H. Christiansen, Mauro Gugliemin, V. E. Romanovsky, N. I. Shiklomanov, Sharon L. Smith, Lin Zhao, David A. Robinson, Mauri Pelto, Carl A. Mears, Shu‐peng Ho, Liang Peng, Junhong Wang, Russell S. Vose, Kyle Hilburn, X. Yin, Michael C. Kruk, Andreas Becker, Michael J. Foster, Steven A. Ackerman, Andrew K. Heidinger, B. C. Maddux, M. Stengel, Hyuanjun Kim, Taikan Oki, Matthew Rodell, D. P. Chambers, J. S. Famiglietti, Wouter Dorigo, Daniel Chung, Robert Parinussa, C. Reimer, S. Hahn, Y. Y. Liu, Wolfgang Wagner, Rochard A.M. de Jeu, Christoph Paulik, Guojie Wang, Rob Allan, Chris K. Folland, Isabelle Tobin, Paul Berrisford, Robert Vautard, Tim R. McVicar, David P. Kratz, Paul W. Stackhouse, Takmeng Wong, P. Sawaengphokhai, Anne C. Wilber, S. K. Gupta, Norman G. Loeb, Kathy Lantz, E. J. Dlugokencky, B. D. Hall, S. A. Montzka, G. S. Dutton, Jens Mühle, J. W. Elkins, Angela Benedetti, Luke T. Jones, Johannes W. Kaiser, J.-J. Morcrette, Samuel Rémy, Mark Weber, Wolfgang Steinbrecht, Johannesprolog Der, Melanie Coldewey‐Egbers, Vitali Fioletov, S. M. Frith, Diego Loyola, Jeannette Wild, Sean Davis, K. H. Rosenlof, O. R. Cooper, J. R. Ziemke, Johannes Flemming, Antje Inness, S. Quegan, Phillipe Ciais, Maurizio Santoro, B. Pinty, Nadine Gobron, Guido R. van der Werf, Michele L. Newlin, Margarita C. Gregg, Yan Xue, Zeng‐Zhen Hu, Арун Кумар, Viva F. Banzon, Thomas M. Smith, Nick A Rayner, Gregory C. Johnson, John M. Lyman, J. K. Willis, Tim Boyer, John I. Antonov, Simon Good, Catia M. Domingues, Nathaniel L. Bindoff, Lisan Yu, Xiangze Jin, Gary Lagerloef, Hsun Ying Kao, James Reagan, Claudia Schmid, Ricardo A. Locarnini, Rick Lumpkin, Gustavo Goñi, Kathleen Dohan, Molly Baringer, Gerard McCarthy, Matthias Lankhorst, David Smeed, Uwe Send, D. Rayner, William E. Johns, Christopher S. Meinen, Stuart A. Cunningham, Torsten Kanzow, Eleanor Frajka‐Williams, Jochem Marotzke, Silvia L. Garzoli, Shenfu Dong, Denis L. Volkov, Will Hobbs, M. A. Merrifield, P. R. Thompson, E. W. Leuliette, R. S. Nerem, Ben Hamlington, Gary T. Mitchum, Kathleen L. McInnes, John J. Marra, Melisa Menéndez, William Sweet, Richard A. Feely, Rik Wanninkhof, Christopher L. Sabine, Jeremy T. Mathis, Taro Takahashi, Samar Khatiwala, Bryan A. Franz, Michael J. Behrenfeld, David A. Siegel, P. Jeremy Werdell, Howard J. Diamond, Gerald D. Bell, Michelle L’Heureux, Michael S. Halpert, Stephen Baxter, Jonathan Gottschalck, Chris Landsea, Stanley B. Goldenberg, Richard J. Pasch, Eric S. Blake, Jae Schemm, Todd B. Kimberlain, Carl J. Schreck, Thomas E. Evans, Suzana J. Camargo, Karin Gleason, Blair Trewin, Andrew M. Lorrey, Nicolas Fauchereau, Petra R. Chappell, S. E. Ready, Gustavo Goñi, John A. Knaff, I.‐I. Lin, Bin Wang, A. Brett Mullan, Alexandre Bernardes Pezza, Caio A. S. Coelho, Chunzai Wang, Chris Fogarty, Philip J. Klotzbach, Jing‐Jia Luo, Mark A. Lander, Charles P.Chip Guard, Martin O. Jeffries, J. Richter-Menge, James E. Overland, Jeff Key, Edward Hanna, Inger Hanssen‐Bauer, B. M. Kim, S. J. Kim, John E. Walsh, Muyin Wang, U. S. Bhatt, Yinghui Liu, R. S. Stone, Christopher J. Cox, Von P. Walden, Jennifer A. Francis, S. J. Vavrus, Qing Tang, G. Bernhard, Gloria Manney, J. U. Grooss, Rolf Müller, Anu Heikkilä, Bjørn Johnsen, Tapani Koskela, Kaisa Lakkala, T. Svendby, Arne Dahlback, L. Bruhwiler, T. Laurila, Douglas E. J. Worthy, Patricia K. Quinn, A. Stohl, Alexander Baklanov, M. Flanner, Andreas Herber, Kaarle Kupiainen, Kathy S. Law, Julia Schmale, Sangeeta Sharma, Vigdis Vestreng, Knut von Salzen, Donald K. Perovich, S. Gerland, S. Hendricks, Walter N. Meier, Marcel Nicolaus, M. Tschudi, Mary Louise Timmermans, Igor Ashik, И. Е. Фролов, H. K. Ha, Randi Ingvaldsen, Tokio Kikuchi, Tae‐Wan Kim, R. Krishfield, Harald Loeng, Shigeto Nishino, R. Pickart, Igor V. Polyakov, Benjamin Rabe, Ursula Schauer, Peter Schlösser, William M. Smethie, V. Sokolov, Michael Steele, John M. Toole, W. Williams, Rebecca Woodgate, Sheryl Zimmerman, Jessica Cross, Wiley Evans, L. W. Anderson, Michiyo Yamamoto‐Kawai, Chris Derksen, Richard J. Brown, Kari Luojus, Martin Sharp, G. Wolken, M. L. Geai, Donald W. Burgess, A. A. Arendt, Bert Wouters, Jack Kohler, Liss M. Andreassen, M. Tedesco, Jason E. Box, John Cappelen, Xavier Fettweis, T.S. Jensen, Thomas L. Mote, Å. K. Rennermalm, L. C. Smith, Roderik S. W. van de Wal, John Wahr, Claude Duguay, L. C. Brown, K.K. Kang, Homa Kheyrollah Pour, D. A. Streletskiy, D. S. Drozdov, Г. В. Малкова, N. G. Oberman, A. L. Kholodov, S. S. Marchenko, Ryan L. Fogt,
Editors note: For easy download the posted pdf of the State of the Climate for 2013 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download.
American Meteorological Society
Rustam Al‐Shahi Salman, Catriona Keerie, Jacqueline Stephen, Steff Lewis, John Norrie, Martin Dennis, David E. Newby, Joanna M. Wardlaw, Gregory Y.H. Lip, Adrian Parry‐Jones, Phil White, Colin Baigent, Daniel Lasserson, Colin Oliver, Fiach C. O’Mahony, Shannon Amoils, John Bamford, Jane Armitage, Jonathan Emberson, Gabriel Rinkel, Gordon Lowe, Karen Innes, Kasia Adamczuk, Lynn Dinsmore, Jonathan Drever, Garry Milne, Allan Walker, Aidan Hutchison, Carol Williams, Ruth Fraser, Rosemary Anderson, Kate Covil, Kelly Stewart, Jessica Rees, Peter Hall, Alistair Bullen, Andrew Stoddart, Tom J. Moullaali, Jeb Palmer, Eleni Sakka, Joanne Perthen, Nicola Lyttle, Neshika Samarasekera, Allan MacRaild, Seona Burgess, Jessica Teasdale, Michelle Coakley, Pat Taylor, Gordon W. Blair, William Whiteley, Susan D. Shenkin, Úna Clancy, Malcolm Macleod, Rachel Sutherland, Tom J. Moullaali, Amanda Barugh, Christine Lerpiniere, Fiona Moreton, Nicholas Fethers, Tal Anjum, Manju Krishnan, Peter Slade, Sharon Storton, Marie Williams, Caroline Davies, Lynda Connor, Glyn Gainard, Carl Murphy, Mark Barber, Derek Esson, James Choulerton, Louise Shaw, Suzanne Lucas, Sarah Hierons, Joanne Avis, Andrew Stone, Lukuman Gbadamoshi, Telma Costa, Lauren Pearce, Kirsty Harkness, Emma Richards, Jo Howe, Christine Kamara, Ralf Lindert, Ali Ali, Jahanzeb Rehan, Sarah Chapman, Maria Edwards, Raj Bathula, David Cohen, Joseph E. Devine, Mushiya Mpelembue, Priya Yesupatham, Swati Chhabra, Gbadebo Adewetan, ROBERT I. W. BALLANTINE, Daniel C. Brooks, Gemma Smith, Gill Rogers, Stuart Marsden, Sarah L. Clark, Ami Wilkinson, Ellen Brown, L Stephenson, Khin Nyo, Annie Abraham, Yogish Pai, Gek Shim, Vidya Baliga, Anand R. Nair, Matthew K. Robinson, C Hawksworth, Jill Greig, Irfan Alam, Tonicha Nortcliffe, Ridha Ramiz, Ryan J. Shaw, Adrian Parry‐Jones, Stephanie J. Lee, Tracy Marsden, Jane Perez, Emily Birleson, Rajendra Yadava, Mirriam Sangombe, Sam G Stafford, Thomas A. Hughes, Lucy Knibbs, Bethan Morse, Stefan Schwarz, Benjamin Jelley, Susan White, Bella Richard, Heidi Lawson, Sally Moseley, Michelle Tayler, Mandy Edwards, Claire Triscott, Rebecca Wallace, Angela Hall, Amanda Dell, Khalid Rashed, Sarah Board, C Buckley, Alfonso Tanate, T Pitt-Kerby, Kate Beesley, Jess Perry, C Hellyer, Paul Guyler, Nisha Menon, Sharon Tysoe, Raji Prabakaran, Martin Cooper, Anoja Rajapakse, Inez Wynter, Susan Smith, Nic Weir, Cherish Boxall, Hannah Yates, Simon Smith, Pamela Crawford, Richard Marigold, Fiona E. Smith, Jake Harvey, Sue Evans, Laura Baldwin, Sarah P. Hammond, Paul N. Mudd, A. Bowring, Samantha Keenan, Kevin E. Thorpe, Mohammad Haque, Joanne Taaffe, Natalie Temple, Tracey Peachey, Kim E. Wells, Fiona Haines, Nicola Butterworth‐Cowin, Zoey Horne, Radim Líčeník, Hayley Boughton, Timothy J. England, Amanda Hedstrom, Brian Menezes, Ruth Davies, Venetia Vettimootal Johnson, Simon Whittingham-Jones, David J. Werring, Sabaa Obarey, C Watchurst, A. Ashton, Shez Feerick, Nina Francia, Azra Banaras, Daniel Epstein, Marilena Marinescu, Annick Williams, Anna M.C. Robinson, Fiona Humphries, Ijaz Anwar, Arunkumar Annamalai, Susan E. Crawford, Vicky Collins, Lorna Shepherd, Elaine Siddle, Justin Penge, Daniel Epstein, Sam Qureshi, Srinivas Murthy, Vasileios Papavasileiou, Dean Waugh, Emelda Veraque, Nathan Douglas, Numan Khan, Sankaranarayanan Ramachandran, Peter Sommerville, Anthony Rudd, Sagal Kullane, Ajay Bhalla, Jonathan Birns, Rowshanara Ahmed, Meegan Gibbons, Ewa Klamerus, Benjie Cendreda, Keith W. Muir, Nicola C. Day, Angela Welch, W. G. J. Smith, Jennifer Elliot, Salwa El Tawil, Ammad Mahmood, Kim Hatherley, Shirley Mitchell, Harjit Bains, Lauren M. Quinn, Rachel Teal, Ivie Gbinigie, George Harston, P Mathieson, Gary A. Ford, Ursula G. Schulz, James Kennedy, Kiruba Nagaratnam, Kiran Bangalore, Neelima Bhupathiraju, Chris Wharton, K. Fotherby, Nasar Ahmad, Angie Stevens, Angela Willberry, Rachel Evans, Baljinder Rai, Chloe Blake, Kamy Thavanesan, Gail Hann, Tanith Changuion, Sara Nix, Amanda Whiting, Michelle Dharmasiri, Louise Mallon, Marketa Keltos, Nigel Smyth, Charlotte Eglinton, John P. Duffy, Ela Tone, Lucy Sykes, Emily Porter, Carolyn Fitton, Nikolaos Kirkineziadis, Gillian Cluckie, Kate Kennedy, Sarah Trippier, Rebecca Williams, Elizabeth Hayter, James Rackie, Bhavini Patel, Rita Ghatala, Adrian Blight, Andrew Jones, Liqun Zhang, Lillian Choy, Anthony Pereira, Brian Clarke, Samer Al‐Hussayni, Lynn Dixon, Andrew Young, Adrian Bergin, David Broughton, Senthil Raghunathan, Benjamin Jackson, Jason P. Appleton, Gwendoline Wilkes, Amanda Buck, Carla Richardson, Judith Clarke, Lucy Fleming,
Background Oral anticoagulation reduces the rate of systemic embolism for patients with atrial fibrillation by two-thirds, but its benefits for patients with previous intracranial haemorrhage are uncertain. In the Start or STop Anticoagulants Randomised Trial (SoSTART), we aimed to establish whether starting is non-inferior to avoiding oral anticoagulation for survivors of intracranial haemorrhage who have atrial fibrillation. Methods SoSTART was a prospective, randomised, open-label, assessor-masked, ...
Elsevier BV
Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi, Yang Wu, Isar Nassiri, Glenn A. McConkey, Marie Zechner, Lucija Klarić, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Anne Richmond, Jonathan Millar, Clark D Russell, Tomas Malinauskas, Ryan S. Thwaites, Kirstie Morrice, Seán Keating, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Julian C. Knight, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Colin B. Begg, Timothy Walsh, Albert Tenesa, Carlos Flores, José A. Riancho, Augusto Rojas‐Martínez, Pablo Lapunzina, Sara Clohisey, Johnny Millar, Manu Shankar‐Hari, Emma Aitkin, Latha Aravindan, Ruth Armstrong, J. Kenneth Baillie, Heather Biggs, Ceilia Boz, Adam Brown, Primmy Chikowore, Richard Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Naomi Kearns, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Christen Lauder, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Sheena Murphy, Hellen Mybaya, Miranda Odam, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Petra Tucker, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Jacqueline Pan, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, R. Chris Whitton, Aneta Bociek, Sara Campos, Gill Arbane, Manu Shankar‐Hari, Marlies Ostermann, Mina Cha, Fabiola DAmato, Eirini Kosifidou, Shelley Lorah, Kyma Morera, Sarah Bircham, Laura Brady, Keith Hugill, Jeremy Henning, Stephen Bonner, Evie Headlam, Jessica Jones, A. List, J Morley, Amy Welford, Bobette Kamangu, Anitha Ratnakumar, Abiola Shoremekun, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Olivier Zongo, S. M. Wood, Anne Zak, David Collier, Manuela Mundy, C. C. Thompson, Lisa Pritchard, Minnie Gellamucho, David Cartlidge, Nageswar Bandla, Lucy Bailey, Michelle Davies, Jane Delaney, Leanne Scott, Marwa Abdelrazik, Frater Alasdair, David Carter, Munzir Elhassan, Arunkumar Ganesan, Samuel Jenkins, Zoe Lamond, Dharam Purohit, Kumar Rohit, Malik Saleem, Alanna Wall, Kugan Xavier, Dhanalaksmi Bakthavatsalam, Kirolos Gehad, Pakeerathan Gnanapragasam, Kapil Jain, Swati Jain, Abdul Malik, Naveen Pappachan, Jerónimo Moreno-Cuesta, Anne Haldeos, Rachel Vincent, Maryjane Oziegb, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Abigail Knighton, Monalisa Nayak, Evita Pappa, Rohit Saha, Sian Saha, Andrew Dodd, Kevin O’Reilly, Mark McPhail, Emma Clarey, Harriet Noble, John Smith, Phoebe Coghlan, Stephen J. Brett, Anthony Gordon, Maie Templeton, David Antcliffe, Dorota Banach, Sarah Darnell, Ziortza Fernandez, Eleanor Jepson, Amal Mohammed, Roceld Rojo, Sonia Sousa Arias, Anita Gurung, Jenny Wong, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, Alicia Waite, Karen Williams, Victoria Waugh, Ingeborg Welters, Jessica Emblem, Maria Norris, David Shaw, Archana Bashyal, Sally Beer, Paula Hutton, Stuart McKechnie, Neil Davidson, Soya Mathew, Grace Readion, Jung Hee Ryu, Jean Wilson, Shruti Agrawal, Kay Elston, Megan Jones, Eoghan Meaney, Petra Polgarova, Muhammad Elbehery, Charlotte Summers, Esther Daubney, Anthony Ng, Jocelyn R. Marshall, Nazima Pathan, Katerina Stroud, Deborah White, Angela Andrew, Saima Ashraf, Amy Clark, Martin Dent, Margaret Langley, Cecilia Peters, Lucy Ryan, Julia Sampson, Shuying Wei, Alice Baddeley, Megan Meredith, Lucy Morris, Alexandra Gibbons, Lisa McLoughlin, Carlos Castro Delgado, Victoria Clark, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Abiola Harrison, William James Hurt, Rebecca Kanu, Ashley Kinch, Susannah Leaver, Ana Lisboa, Jisha Mathew, Kamal Patel, Romina Pepermans Saluzzio, John Rawlins,
Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown
Nature Portfolio
Masahiro Kanai, Shea J. Andrews, Mattia Cordioli, Christine Stevens, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Akiko Iwasaki, Juha Karjalainen, Juha Mehtonen, Matti Pirinen, Karolina Chwiałkowska, Amy Trankiem, Mary K. Balaconis, Kumar Veerapen, Brooke N. Wolford, Hajar Fauzan Ahmad, Shea J. Andrews, Kathrin Aprile von Hohenstaufen Puoti, Cindy G. Boer, Palwendé Romuald Boua, Guillaume Butler‐Laporte, Carmen L. Cadilla, Karolina Chwiałkowska, Francesca Colombo, Venceslas Douillard, Nicole Dueker, Atanu Kumar Dutta, Yasser M. El‐Sherbiny, Madonna M. Eltoukhy, Sahar Esmaeeli, Annika Faucon, Marie-Julie Favé, Israel Fernández Cadenas, Margherita Francescatto, Laurent C. Francioli, Lude Franke, Macarena Fuentes‐Guajardo, Rocío Gallego Durán, David Gómez-Cabrero, Emi N. Harry, Philip R. Jansen, József Szentpéteri, Elżbieta Kaja, Masahiro Kanai, Chloe Kirk, Athanasios Kousathanas, José Eduardo Krieger, Sanjay Patel, Audrey Lemaçon, Sophie Limou, Píetro Lió, Eirini Marouli, M. Marttila, Carolina Medina‐Gómez, Yael Michaeli, Isabelle Migeotte, Soumyajit Mondal, Andrés Moreno‐Estrada, Leire Moya, Tomoko Nakanishi, Jamal Nasir, Dorote Pasko, Nathaniel M. Pearson, Alexandre C. Pereira, James R. Priest, Vid Prijatelj, Ivana Nedeljković, Alexander Teumer, Réka Várnai, Manuel Romero‐Gómez, Christina Roos, Jeffrey Rosenfeld, Ruolin Li, Eva C. Schulte, Claudia Schurmann, Bahareh Sedaghati-khayat, Doaa Shaheen, Ilangumaran Shivanathan, Csilla Sipeky, Zhou Sirui, Pasquale Striano, Yosuke Tanigawa, Alicia Utrilla Remesal, Nirmal Vadgama, Costanza L. Vallerga, Sander W. van der Laan, Ricardo A. Verdugo, Qingbo Wang, Wei Zhou, Ummu Afeera Zainulabid, Ruth N. Zárate, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Catherine H. Weldon, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Alexander S. Hatoum, Amit Agrawal, Ryan Bogdan, Sarah M. C. Colbert, Wesley K. Thompson, Chun Fan, Emma C. Johnson, Lyudmila Niazyan, Mher Davidyants, Arsen Arakelyan, Diana Avetyan, Makhabbat Bekbossynova, Ainur Tauekelova, Mukhtar Tuleutayev, Aliya Sailybayeva, Yerlan Ramankulov, Elena Zholdybayeva, Jarkyn Dzharmukhanov, Kuat Kassymbek, Tatyana Tsechoeva, Gulsimzhan Turebayeva, Zauresh Smagulova, Timur Muratov, Sadyk Khamitov, Alex S. F. Kwong, Nicholas J. Timpson, Mari Niemi, Souad Rahmouni, Julien Guntz, Y Beguin, Mattia Cordioli, Sara Pigazzini, Lindokuhle Nkambule, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Stéphanie Gofflot, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Nicky Tiembe, David Morrison, Jonathan Afilalo, Vincent Mooser, J. Brent Richards, Simon Rousseau, Madéleine Durand, Guillaume Butler‐Laporte, Vincenzo Forgetta, Lætitia Laurent, Zaman Afrasiabi, Meriem Bouab, Chris Tselios, Xiaoqing Xue, Marc Afilalo, Maureen Oliveira, Janick St-Cyr, Ariane Boisclair, Jiannis Ragoussis, Daniel Auld, Daniel E. Kaufmann, G. Mark Lathrop, Guillaume Bourque, Simon Décary, Emilia Liana Falcone, Alexandre Montpetit, Alain Piché, Christel Renoux, Natàlia Blay, Sze Man Tse, Ma’n H. Zawati, Lea K. Davis, Nancy J. Cox, Jennifer E. Below, Julia Sealock, Annika Faucon, Megan M. Shuey, Hannah G. Polikowsky, Lauren E. Petty, Douglas M. Shaw, Hung‐Hsin Chen, Wanying Zhu, Axel Schmidt, Kerstin U. Ludwig, Carlo Maj, Selina Rolker, Daniella Balla, Pari Behzad, Markus M. Nöthen, Julia Fazaal, Verena Keitel, Verena Keitel, Björn‐Erik Ole Jensen, Torsten Feldt, Nikolaus Marx, Michael Dreher, Isabell Pink, Markus Cornberg, Thomas Illig, Clara Lehmann, Philipp Schommers, Jan Rybniker, Max Augustin, Lisa Knopp, Ingo Kurth, Thomas Eggermann, Sonja Volland, Marc Moritz Berger, Thorsten Brenner, Anke Hinney, Oliver Witzke, Margarethe Konik, Robert Bals, Christian Herr, Nicole Ludwig, Jörn Walter, Eicke Latz, Susanne V. Schmidt, Jennifer D. Brooks, Shelley B. Bull, Lloyd T. Elliott, France Gagnon, Celia M.T. Greenwood, Rayjean J. Hung, Jerry Lawless, Andrew D. Paterson, Lei Sun, Michael J. Rauh, Laurent Briollais, Anne‐Claude Gingras, Yvonne Bombard, Trevor J. Pugh, Jared T. Simpson, Lee Goneau, Anat R. Halevy, David M. Maslove, Bjug Borgundvaag, Luke Devine, Erin Bearss, David Richardson, Saranya Arnoldo, Steven Friedman, Ahmed Taher, Seth Stern, Marc Dagher, Jovanka Vasilevska‐Ristovska, Catherine M. Biggs, Beata Mickiewicz, Lisa J. Strug, Stephen W. Scherer, Naveed Aziz, Steven J.M. Jones, Bartha Maria Knoppers, Mark Lathrop, Stuart E. Turvey, Rae S. M. Yeung, Upton Allen, Angela M. Cheung, Margaret S. Herridge, Miranda Hunt, Jordan Lerner‐Ellis, Jennifer Taher, Rulan S. Parekh, Linda T. Hiraki, Juthaporn Cowan, Francine M. Ducharme, Mario Ostrowski, François P. Bernier, Jim Kellner, Elika Garg, Samantha Yoo, Caitlyn Vlasschaert, Erika Frangione, Monica Chung, Abdul Noor, Elena Greenfeld, Karen Colwill, Marc Clausen, Gary Chao, FengYun Yue, Marvin J. Fritzler, Joseph Whitney, Bhooma Thiruvahindrapuram, Jean‐Michel Garant, Rohan Abraham, Adrienne D. Davis, Aaron Campigotto,
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1,2 .Here we present a second updated genome-wide association study (GWAS) on COVID-19 severity and infection susceptibility to SARS-CoV-2 from the COVID-19 Host Genetic Initiative (data release 7).We performed a meta-analysis of up to 219,692 cases and over 3 million controls, identifying 51 ...
Nature Portfolio
Camilla Andersen, Yuichi Yoshimura, Janni Nielsen, Daniel E. Otzen, Frans A. A. Mulder,
... L. Lee V.M.Y. Trojanowski J.Q. Jakes R. Goedert M. α-Synuclein in Lewy bodies. ... Google Scholar, 2Spillantini M.G. Crowther R.A. Jakes R. Hasegawa M. Goedert M. alpha-Synuclein in ... G. Pedersen S.V. Staal R. Krishnamurthy G. Pitts K. Reinhart P.H. et al.Novel α- ... G. Pedersen S.V. Staal R. Krishnamurthy G. Pitts K. Reinhart P.H. et al.Novel α- ...
Tópico(s): Ginkgo biloba and Cashew Applications
2021 - Elsevier BV | Journal of Biological Chemistry
Hironori Ogawa, Ayako Murayama, Shigekazu Nagata, Rikiro Fukunaga,
... 17926Google Scholar, 49Goedert M. Cuenda A. Craxton M. Jakes R. Cohen P. EMBO J. 1997; 16: 3563- ... p38δ/SAPK4 (49Goedert M. Cuenda A. Craxton M. Jakes R. Cohen P. EMBO J. 1997; 16: 3563- ...
Tópico(s): Histone Deacetylase Inhibitors Research
2003 - Elsevier BV | Journal of Biological Chemistry
Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, A Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Christopher Aboah, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, J. Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Faustina Acheampong, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Lawrence Addai-Boampong, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Shanti A Adhikari, Rina Adhikary, Adhikarla Aditya, Patience Adjepong, Gabrielle Adkins, Adnan Adnan, Marguerite Adriaanse, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Iqbal Afridi, Patricia Afrim, Felicia Akua Afriyie, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, L A Aguilar Jimenez, Jacqueline Afrakomah Agyekum, Kwame Agyen, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Mohammad Ahmad, Syed A. Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Bilal A Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Albertus Albertus, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al‐Hity, Ali Ali, Amanda Ali, Ali Asad, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed M. Ali, Mohammad Ali, Muhammad Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Syed Ahsan Ali, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Bachti Alisjahbana, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, A. Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al‐Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Amel Amelia Ganefianty, Katharine Ames, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, James Amoah-Dankwa, Victoria Amosun, Muhammad Amsal,
BackgroundLow-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive mechanical ventilation, or extracorporeal membrane oxygenation). We evaluated the use of a higher dose of corticosteroids in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing multiple possible treatments in patients hospitalised ...
Elsevier BV
Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, D. Abdo, Basir Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Amina Abdulle, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmad Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andrés Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Sara J. Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Lisa C. Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Debo Ademokun, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Dominic Affron, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Humayun Ahmad, Mohammad Ahmad, Syed A. Ahmad, Asim A. Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Sophia Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Giulia Airoldi, Myriam Aissa, Lindianne Aitken, Bini Ajay, Francis Ajeneye, Abdulakeem Ajibode, Ayesha Ajmi, Tahir Akbar, Naim Akhtar, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olajide Akinwumiju, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Karina Al-Asadi, Kyriaki S. Alatzoglou, Manaf Al-Bayati, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John H. Alexander, Peter Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al‐Hity, Ali Ali, Asad Ali, Fawzia R Ali, Hoodo Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sabira Ali, Sakina Ali, Syed Ahsan Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Allameddine Allameddine, Fiona Allan, Rachel Allan, Alison Allanson, Robert Allcock, B. Allen, Eireann Allen, Jess Allen, Kerry Allen, Laura K. Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Bashar Al‐Sheklly, Sara Altaf, Mary Alvarez, Balaal Alyas, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Kenneth Amenyah, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Mariam Ammoun, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Rekha Anand, Samantha Anandappa, Julie Anderson, Kevin L. Anderson, Laura Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy G. Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Susan Andrews, Gregory Andrikopoulos, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Anu Varghese, Muhammad Naveed Anwar, George Apostolides, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Aquino, Bianca Araba, Samuel Aransiola, Mariana E. G. de Araújo, Emily Arbon, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Sylvia Armstrong‐Fisher, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold,
BackgroundMany patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. ...
Elsevier BV
Obbina Abani, Ali Abbas, Fatima Abbas, Joshua Abbas, Kasim Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Alison Abbott, Nabeel Abdallah, Ammar Abdelaziz, Ashraf Omar Abdelaziz, Mohamed S. Attia, Bushra Abdelqader, A Abdul, Basir Abdul, Siddiqui Abdul, Althaf Abdul Rasheed, Abdulakeem Ajibode, Rezan A. Kadir, Abdullah Abdullah, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Lynn Abel, Katrina Abernethy, Movin Abeywickrema, Chandra Abhinaya, Affyarsyah Abidin, Adebanke Aboaba, Abigail Aboagye-Odei, Heba Aboelela, Hani Abo-Leyah, Karim Abouelela, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Ahmed Abousamra, Mona Abouzaid, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Rebecca Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yousuf Abusamra, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Prince Acheampong, Sarah Acheampong, Janet Acheson, Shiella Achieng, Andrés Acosta, Rebecca Acquah, Catherine Acton, Jacqueline Adabie-Ankrah, Paul Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Marta Adamczyk, Carol Adams, Charlotte Adams, Daniel Adams, Kate Adams, Laura Adams, Nikkita Adams, Richard Adams, Tim Adams, Laura Adamu-Ikeme, Krishma Adatia, Kirsty Adcock, Afua Addo, Oluwatobi Adeagbo, Ade Adebiyi, Ogunlana Adedeji, Yewande Adegeye, Ken Adegoke, Vicki Adell, Sherna Adenwalla, Femi W Adeoye, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Adedamola Adeyanju, Joyce Adeyemi, Tenifayo Adeyemo, Binay Adhikari, Rina Adhikary, Adhikarla Aditya, Gabrielle Adkins, Adnan Adnan, John Aeron‐Thomas, Debbie Affleck, Carmel Afnan, Muhammad Abdur Rahman Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Sunil Aggarwal, Arameh Aghababaie, L A Aguilar Jimenez, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, M. Ridwan Said Ahmad, Syed A. Ahmad, Afshan Ahmed, Ashar Ahmed, Asim Ahmed, Basheer A R Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Hanad Ahmed, Irshad Ahmed, Khaled Ahmed, Khalil Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S. Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rawya Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sana Ahmed, Syed Haris Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Bilal A Mohamud, Sana Ahmed, Sana Ahmer, Augustine Ahonia, C Aiken, Dhiraj Ail, Mark Ainsworth, Myriam Aissa, Lindianne Aitken, Bini Ajay, Abdulakeem Ajibode, Ayesha Ajmi, Nasim Akhtar, Nauman Akhtar, Suha Akili, Bolutito Akinbiyi, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Mohammad Akram, Olugbenro Aktinade, Uzayr Akudi, Ahmad S A R Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al‐Abadi, Adegoke Alabi, Narendra Aladangady, Mohamed Alafifi, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Kyriaki S. Alatzoglou, Paul Albert, Lorraine Albon, Angela Alcala, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Abdullah Aldesouki, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ram Maya Ale, Ana Alegria, Alison Alexander, Courtney Alexander, John H. Alexander, Peter Alexander, Julyan Al-Fori, Laith Alghazawi, Osama Alhabsha, Bahij Al-Hakim, Rafil Alhameed, Mohammed Al-Hayali, Shams Al‐Hity, Ali Ali, Amanda Ali, Asad Ali, Fawzia R Ali, Jawad Ali, Mariam Ali, Mohamed M. Ali, Mohammad Ali, Muhammad Ali, Nayab Ali, Oudai Ali, Ramla Ali, Sakina Ali, Irfan Syed, Emilio Aliberti, J Alin, Abid Alina, Analyn Alipustain, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, A. Alkhudhayri, Moutaz Alkhusheh, Fiona Allan, Nataliya Allan, Alison Allanson, Robert Allcock, Eireann Allen, Jade Allen, Kerry Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Tania Allen, Abiola Alli, Kathryn Allison, Bethan Allman, Helen K Allsop, Lynne Allsop, David Allsup, Amal Almahroos, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Riyam Al-Sammarraie, Inji Alshaer, Rustam Al‐Shahi Salman, Warkaq Al-Shamkhani, Fadia Alsheikh, Bashar Al‐Sheklly, Sara Altaf, Amanda Alty, Mary Alvarez, Maria Alvarez Corral, Edward Alveyn, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Katharine Ames, Maria R. Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Badshah Amit, Amjad Amjad, Neelma Amjad, Victoria Amosun, Muhammad Amsal, Khaled Amsha, Noelia Martín, Pugh Amy, Ann Anada, Atul Anand, Samantha Anandappa, Satya D Anantapatnaikuni, Ellen Anderson, Julie Anderson, Laura Anderson, Marina Anderson, Michelle A. Anderson, Nicola Anderson, Rachel Anderson,
BackgroundWe aimed to evaluate the use of baricitinib, a Janus kinase (JAK) 1–2 inhibitor, for the treatment of patients admitted to hospital with COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple possible treatments in patients hospitalised with COVID-19 in the UK. Eligible and consenting patients were randomly allocated (1:1) to either usual standard of care alone (usual care group) or usual care plus ...
Elsevier BV
Edna Bonacich, Jake Alimahomed‐Wilson,
... farming Notes Sylvia Allegretto, Ary Amerikaner, and Steven Pitts, Data Brief: Black Unemployment in November 2010 (Berkeley: ... Research and Education, UC Berkeley, 2010). Steven C. Pitts, Job Quality and Black Workers: An Examination of ...
Tópico(s): Urban Agriculture and Sustainability
2011 - Taylor & Francis | Souls
... 04.002Elizabeth M. Da Silva, Vashti M. King, Jake L. Russell-Mercier, Risa D. Sargent Evidence for ...
Tópico(s): Botany and Plant Ecology Studies
1988 - University of Chicago Press | The American Naturalist
Jean-François Crétaux, William Sweet, Jake Crouch, Taro Takahashi, Stuart A. Cunningham, Michael A.P. Taylor, Richard de Jeu, M. Tedesco, Mesut Demircan, Jean‐Noël Thépaut, Chris Derksen, Wassila M. Thiaw, Howard J. Diamond, P. R. Thompson, E. J. Dlugokencky, Peter Thorne, Kathleen Dohan, Mary‐Louise Timmermans, A. J. Dolman, Skie Tobin, Wouter Dorigo, John M. Toole, D. S. Drozdov, Katja Trachte, Claude Duguay, Blair Trewin, Ellsworth G Dutton, Ricardo M. Trigo, G. S. Dutton, Adrian Trotman, J. W. Elkins, C. Tucker, H. E. Epstein, Yusuf Ulupinar, J. S. Famiglietti, Roderik S. W. van de Wal, Odile Hembise Fanton d’Andon, Guido R. van der Werf, Richard A. Feely, Robert Vautard, B M Fekete, Gary Votaw, Chris Fenimore, Wolfgang Wagner, Diego Fernández‐Prieto, John Wahr, Erik Fields, D. A. Walker, Vitali Fioletov, J. Brandon Walsh, Ryan L. Fogt, Chunzai Wang, Chris K. Folland, Junhong Wang, Michael J. Foster, Lei Wang, Eleanor Frajka‐Williams, Menghua Wang, Bryan A. Franz, Sheng-Hung Wang, Karen E. Frey, Rik Wanninkhof, S. M. Frith, Scott C. Weaver, И. Е. Фролов, Mark Weber, Gerald V. Frost, Thomas J. Weingartner, Catherine Ganter, Robert A. Weller, Silvia L. Garzoli, Frank Wentz, Wilson Gitau, R. Whitewood, Karin Gleason, Anne C. Wilber, Nadine Gobron, Kate M. Willett, Stanley B. Goldenberg, W. Williams, Gustavo Goñi, J. K. Willis, Idelmis Gonzalez-Garcia, R. C. Wilson, Nivaldo Gonzalez-Rodriguez, G. Wolken, Simon Good, Takmeng Wong, Philippe Goryl, Rebecca Woodgate, Jonathan Gottschalck, Alex J. Wovrosh, Célia M. Gouveia, Yan Xue, Margarita C. Gregg, Ryuji Yamada, Georgina M. Griffiths, Michiyo Yamamoto‐Kawai, Valentina Grigoryan, James A. Yoder, Jens‐Uwe Grooß, Lisan Yu, Chip Guard, Simon Yueh, Mauro Guglielmin, Liangying Zhang, B. D. Hall, Peiqun Zhang, Michael S. Halpert, Lin Zhao, Andrew K. Heidinger, Xinjia Zhou, Anu Heikkilä, Sheryl Zimmerman, Richard R. Heim, Lafeer Zubair, P. Hennon, Hugo G. Hidalgo, Kyle Hilburn, Shu‐peng Ho, Will Hobbs, Simon Holgate, Simon J. Hook, Anahit Hovsepyan, Zeng‐Zhen Hu, Sebastien Hugony, D. F. Hurst, Randi Ingvaldsen, Masahiro Itoh, Ena Jaimes, Martin O. Jeffries, William E. Johns, Bjørn Johnsen, Bryan Johnson, Gregory C. Johnson, Lester Tallmon Jones, Guillaume Jumaux, K. Kabidi, Johannes W. Kaiser, Kyun-Kuk Kang, Torsten Kanzow, Hsun‐Ying Kao, Linda M. Keller, Mike Kendon, John Kennedy, Sefer Kervankiran, J. M. KEY, Samar Khatiwala, A. L. Kholodov, M. Khoshkam, Tokio Kikuchi, Todd B. Kimberlain, Darren King, John A. Knaff, Natalia N. Korshunova, Tapani Koskela, David P. Kratz, R. Krishfield, Andries Kruger, Michael C. Kruk, Арун Кумар, Gary Lagerloef, Kaisa Lakkala, Richard B. Lammers, Mark A. Lander, Chris Landsea, Matthias Lankhorst, Braulio Lapinel-Pedroso, Matthew A. Lazzara, Sharon Leduc, Penehuro Lefale, Gloria León, Antonia Leon-Lee, E. W. Leuliette, S. Levitus, Michelle L’Heureux, I.‐I. Lin, Hongxing Liu, Yanju Liu, Yi Liu, René Lobato-Sánchez, Ricardo A. Locarnini, Norman G. Loeb, Harald Loeng, Craig S. Long, Andrew M. Lorrey, Rick Lumpkin, Cathrine Lund Myhre, Jing‐Jia Luo, John M. Lyman, Stuart N MacCallum, Alison M. Macdonald, B. C. Maddux, Gloria Manney, S. S. Marchenko, José Marengo, Stéphane Maritorena, Jochem Marotzke, John J. Marra, Odayls Martinez-Sanchez, James A Maslanik, RA Massom, Jeremy T. Mathis, C. Mcbride, Charles R. McClain, Daniel McGrath, Simon McGree, F. L. McLaughlin, Tim R. McVicar, Carl A. Mears, Walter N. Meier, Christopher S. Meinen, Melisa Menéndez, Christopher J. Merchant, M. A. Merrifield, Laury Miller, Gary T. Mitchum, S. A. Montzka, Sue E. Moore, Natalie P. Mora, Jean‐Jacques Morcrette, Thomas L. Mote, Jens Mühle, A. Brett Mullan, Rolf Müller, Cathrine Lund Myhre, Eric R. Nash, R. S. Nerem, Michele L. Newlin, Paul A. Newman, A. Z. Ngari, Shigeto Nishino, L.N. Njau, Jeannette Noetzli, N. G. Oberman, André Obregón, Laban Ogallo, Christopher Oludhe, James E. Overland, Lamjav Oyunjargal, Robert Parinussa, Geun-Ha Park, D. E. Parker, Richard J. Pasch, Reynaldo Pascual-Ramirez, Mauri Pelto, Olga C. Penalba, Ramon Perez-Suarez, D. Perovich, Alexandre Bernardes Pezza, Dave Phillips, R. Pickart, C. Achberger, B. Pinty, Steven A. Ackerman, Jorge Enrique Díaz Pinzón, Farid H. Ahmed, M. C. Pitts, Adelina Albanil-Encarnacion, Homa Kheyrollah Pour, E. J. Alfaro, John O. Prior, L. M. Alves, J. L. Privette, Rob Allan, Andrey Proshutinsky, Jorge A. Amador, S. Quegan, Peter Ambenje, Juan Quintana, David Antoine, Benjamin Rabe, John I. Antonov, Fatemeh Rahimzadeh, Juan Carlos Arévalo, M. Rajeevan, Derek S. Arndt, D. Rayner, Igor Ashik, Nick A Rayner, Zachary Atheru, M. K. Raynolds, Alessandro Baccini, V. N. Razuvaev, Julián Baéz, James Reagan, Viva F. Banzon, Phillip Reid, Molly Baringer, James Renwick, Sandra Barreira, J. V. Revadekar, David Barriopedro, Markus Rex, John J. Bates, J. Richter-Menge,
Editors note: For easy download the posted pdf of the State of the Climate for 2011 is a very low-resolution file. A high-resolution copy of the report is available by clicking here. Please be patient as it may take a few minutes for the high-resolution file to download. Supplemental figures and datasets are available here.
American Meteorological Society
Myoung‐jin Jang, Miri Jwa, Jung-Ho Kim, Kiwon Song,
... 316) Google Scholar, 19.Goedert M. Hasegawa M. Jakes R. Lawler S. Cuenda A. Cohen P. FEBS ...
Tópico(s): Fungal Biology and Applications
2002 - Elsevier BV | Journal of Biological Chemistry