By David Wood Political Editor, By Our Labour Editor, By Paul Routledge and Tim Jones, By Malcolm Brown, By Staff Reporters, From Edmund Stevens, From Douglas Aiton, By Our Political Staff, By Michael Horsnell, From Stewart Tendler, By Martin Huckerby Political Staff, By Hugh Clayton, By Clifford Longley Religious Affairs Correspondent, By Hugh Noyes Parliamentary Correspondent, By Gabriel Ronay, By a Staff Reporter, By David Spanier Diplomatic Correspondent, From Our Correspondent, By Arthur Reed Air Correspondent, By John Young Planning Renorter, By Our Planning Reporter, By Pearce Wright Science Editor, By Cyril Bainbridge, By Our Arts Reporter, By Michael Hatfield Political Stafff, From Michael Hornsby, From Harry Debelius, From Dan van der Vat, From David Cross, From Charles Hargrove, From Our Own Correspondent, From Peter Strafford, From Eric Marsden, From Patrick Brogan, From Fred Emery, Philippa Toomey, By Geraldine Norman Sale Room Correspondent, John Percival, Irving Wardle, Charles Lewsen, William Mann, Jeffery Daniels, Alan Coren, Stanley Reynolds, Alan Blyth, By Geoffrey Green Football Correspondent, By Neil Allen Athletics Correspondent, By Peter West Rugby Correspondent, By Michael Seely, By Rex Bellamy Tennis Correspondent, By Sydney Friskin, Mario Modiano, Professor Walter Laqueur, Ronald Butt, PHS, Denis Taylor, K. G. PRATT, , MICHAEL J. BELLIS, , MICHAEL FINLEY, , KEN CHAMBERLIN, , VANESSA REDGRAVE, , G. SELVA RAJAN, , REG GOODWIN, , JANET MORGAN, , A. E. YOUNG, , S. E. Thames, D. F. H. WARDLE, , N. W. Thames, J. W. EDDY, , N. E. Thames, P. COYLE, , S. W. Thames, NORMAN T. COX, , MARIA W. HARNDEN, , NIGEL J. SEED, , NIGEL DEMPSTER, , JOHN WALL, , MICHAEL RUBINSTEIN, , A correspondent writes:, A. D. B. writes:, Derek Parker, Myrna Blumberg, Jan Stephens, Michael Ratcliffe, Kay Dick, Robert Nye, Jan Morris, By Peter Hill Industrial Correspondent, By Paul Routledge Labour Editor, By Patricia Tisdall, By Our Financial Staff, By Christopher Wilkins, By David Blake, By Edward Townsend, By Melvyn Westlake, By Roger Vielvoye Energy Correspondent, By Peter Hill, By Arthur Reed, By David Young, By Kenneth Owen, Technology Correspondent, From Frank Vogl, GEOFFREY DRAIN, B. A. COLE, , M. SWISS, , S. V. STRAKER, , WALTER P. W. ELWELL, , BY THE FINANCIAL EDITOR, Peter Jay, By Peter Elliott, Peter Waymark,
... examine energy policy proposed, Aerial robots with the James Bond touch. Index. News in Brief. Display Advertising: Unilever, Ppa, Hans Eysenck & Glenn Wilson, General Accident, Baric, Michael Joseph, Sony, Hodder & Stoughton, Miln Marsters, Croft Distinction,, Problem, Bank Base Rates, Foyles Art ...
1975 - Gale Group | TDA
Teddy G. Traylor, Douglas Magde, James C. Marsters, Karen A. Jongeward, Guo Zhang Wu, Kevin N. Walda,
... polarity, and viscosity effectsTeddy G. Traylor, Douglas Magde, James Marsters, Karen Jongeward, Guo Zhang Wu, and Kevin WaldaCite ...
Tópico(s): Magnetism in coordination complexes
1993 - American Chemical Society | Journal of the American Chemical Society
Andrew Robson, Marion McGilvary, Simon Barnes Chief Sports Writer, Alexandra Frean Social Affairs Correspondent and Sam Lister, Jeremy Skidmore, Helen Studd, Robert Cole, Catherine Riley, DJM, James Moore, Zahid Hussain, Adam Sherwin Media Reporter, Sarah Potter, Brian Martelli, Magnus Linklater, Richard Beeston John Phillips and James Bone, Claire McDonald, Mark Souster, Mark Frary, Richard Hobson, Geoffrey MacNab, Ivo Tennant, Edward Underhill, Michael Evans Defence Editor, Philip Howard, Jennal Cox Fitness Editor, David Chater, Jeremy Kingston, Lucy Hawking, Nic Hopkins, Gabrielle Starkey, Barbara Ellen, Kevin Eason, Geoff Brown, Amon Cohen, Geoffrey Beard, Sam Lister, Joe Joseph, Lea Paterson, Gary Duncan and Philip Webster, Pat Gibson, David McVay, Michael Ogden, Tom Baldwin and Gary Duncan, Thrasy Petropoulos, Jack Malvern, Dominic Walsh, Steve Bird, David Furst, Stephen Farrell and Richard Beeston Diplomatic Editor, Alan Hamilton, Oliver Wright, Jenny MacArthur, Alice Lagnado, Gerald Mortimer, Ian Bradley, Malika Browne, Charles Bremner, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Damian Barr, Mark Court, Caroline Merrell Banking Correspondent, Angela Jameson, Reg Andlaw, Neil Wallis, Vanora Bennett, Nick Thomas, Giles Whittell and Abigail Rayner, Rick Broadbent, Tom Baldwin, David Pinnegar, Jill Sherman Whitehall Editor, Robert Bruce-Chwatt, Geoffrey Lloyd, Simon de Bruxelles, John Hopkins Golf Correspondent, Gwyneth A. Jeyes, Neil Harman Tennis Correspondent, Charles Leadbeater, Raymond Keene, Philip Whiteley, Robert Cole Tempus Editor, Philip Webster and Roland Watson, Philip Webster and James Doran, Greg Hurst Parliamentary Correspondent, Peta Bee, Neville Scott, Bronwen Maddox, Richard Owen, Anthony Browne Environment Editor, Christopher Martin-Jenkins Chief Cricket Correspondent, Jill Sherman and Peter Riddell, Nick Hasell, Alison Kervin Chief Sports Feature Writer, Julian Muscat, John Allison, William Rees-Mogg, John Goodbody, Dominic Kennedy, Les Wayles, James Doran, Philip Webster Political Editor, Katty Kay, Tim Hames, Des Dearlove, Ian Johns, Brian Morgan, Guy Liardet, Edward McMillan-SCOTT, Richard Heller, Chris McGrath, Michael Smith, Russell Jenkins, Michael Austin, Peter Riddell, Ben MacIntyre, Brian Murgatroyd, John Goodbody Sports News Correspondent, Tony Dawe, Beryl M. Goldsmith, David Charter Chief Political Correspondent, Alison Gibson, Michael Dynes, Chris Quick, Ingrid Ehrlich, Anne Ashworth Personal Finance Editor, Martin Waller, Mark Henderson, Chris Ayres, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Laura Peek, Benedict Nightingale, Antonia Senior and Helen Nugent, Stephen Dalton, Dr Thomas Stuttaford, Jack Bailey, Alyson Rudd, Tom Chesshyre, Richard Morrison, James Christopher, Susan MacDonald, Geoffrey Warner, Allan Hall, Owen Slot, Jenny Davey, David Robertson, Sally Patten Retail Correspondent, Patience Wheatcroft, Carolyn Robinson,
... mug ban In Brief Official ruling Open contest Marsters moves Hall on target Welsh date Cole hot ... Russian mail-order bride in Birthday Girl, says James Christopher Winner A reality stranger than his fiction ...
2002 - Gale Group | TDA
Scot A. Marsters, James P. Sheridan, Christopher J. Donahue, Robert Pitti, Christa L. Gray, Audrey D. Goddard, Kenneth D. Bauer, Avi Ashkenazi,
Background Two receptors that contain the so-called 'death domain' have been described to date: tumor necrosis factor receptor 1 (TNFR1) and Fas/Apo-1 (CD95); both belong to the TNFR gene family. The death domain of TNFR1 mediates the activation of programmed cell death (apoptosis) and of the transcription factor NF-κB, whereas the death domain of CD95 only appears to activate apoptosis.Results We have identified an additional member of the TNFR family, which we have named Apo-3. Apo-3 is a transmembrane ...
Tópico(s): Cell Adhesion Molecules Research
1996 - Elsevier BV | Current Biology
From Marvine Howe, By Our Foreign Staff, By Fred Emery Political Editor, By Christopher Thomas Labour Reporter, By Hugh Noyes Parliamentary Correspondent, By David Blake Economics Correspondent, From John Noble Wilford, By Paul Routledge Labour Editor, By Our Labour Staff, By Our Arts Reporter, By Cyril Bainbridge, By Stewart Tendler Home Affairs Reporter, By Roger Berthoud, By a Special Correspondent, By Our Political Editor, By Michael Hatfield Political Reporter, By Kenneth Gosling, By Pat Healy Social Services Correspondent, By Peter Hennessy, By Christopher Warman Local Government Correspondent, By Martin Huckerby Music Reporter, By John Young Planning Reporter, By John Huxley Business News Staff, From Arthur Osman, By Peter Evans Home Affairs Correspondent, By Philip Howard, By Diana Geddes Education Correspondent, By Annabel Ferriman, By John Roper Health Services Correspondent, By Our Political Staff, By Our Education Correspondent, By Ronald Kershaw Northern Industrial Correspondent, From Jose Shercliff, From Our Own Correspondent, From Charles Hargrove, From Patricia Clough, From Eric Marsden, From Our Correspondent, By David Watts, By Our Diplomatic Correspondent, From David Cross, From Edward Mortimer, From Andrew Tarnowski, From Arthur Reed Air Correspondent, From Michael Leapman, From Patrick Brogan, Paul Barker, Humphry Berkeley, Laurence Cotterell, Peter Tinniswood, H. R. F. Keating, Philippa Toomey, Henry Stanhope, John Higgins, John Percival, Jeremy Treglown, Alan Coren, Paul Griffiths, Ned Chaillet, Joan Chissell, Barry Millington, By Tom German, From Rex Bellamy Tennis Correspondent, By Peter West Rugby Correspondent, By Michael Seely, By Srikumar Sen, By Sydney Friskin, by Prudence Glynn, Ronald Butt, Nicholas Ashford, PHS, Peter Evans Home Affairs Correspondent, W. E. BUTLER, , CLIVE DAVTIES, , ERIC MIDWINTER, , WILLIAM SHELTON, , ILYA GERSHEVITCH, , DENIS MAHON, , J. DAVIES, , J. W. SAUNDERS, , DAVID HIRST, , CLEMENT FREUD, , LAURA BALLANTRAE, , J. D. EVANS, , A. L. F. RIVET, , DONALD HARDEN, , A. R. C. de CRESPIGNY, , A. W. BEER, , PIERS JESSOP, , By Geraldine Norman Sale Room Correspondent, A correspondent, By Nicholas Hirst, From Patricia Tisdall, By Caroline Atkinson, By Christopher Wilkins, From Frank Vogl, By Bryan Appleyard, By Our Industrial Staff, By John Huxley, By Roger Vielvoye, From Richard Allen, From John Earle, From Michael Hornsby, By Derek Harris, By Malcolm Brown, I. E. C. GRANT, , By Maurice Corina Industrial Editor, MICHAEL J. FRENCH, , DAVID F. McCURRACH, , OLIVER CAIGER-SMITH, , BY THE FINANCIAL EDITOR, Hugh Clayton, Melvyn Westlake, By Desmond Quigley, By Victor Felstead, By Alison Mitchell, Ross Davies, Peter Waymark, by Michael Hanson, M.H., by Christopher Warman, C.W., by John Young, J.Y.,
... Ncr Computers & Terminals, Jones Lang Wootton, The Miln Marsters Group Limited, Glen Grant Distillery, Slogh Estates Ltd,, ... for stolen export whisky to include excise duty James Buchanan & Co Ltd v Babco Forwarding and Shipping ( ...
1977 - Gale Group | TDA
Scot A. Marsters, James P. Sheridan, Robert Pitti, Arthur Huang, Maya Skubatch, Daryl T. Baldwin, Jianwei Yuan, Austin Gurney, Audrey D. Goddard, Paul J. Godowski, Avi Ashkenazi,
Apo2 ligand (Apo2L [[1]Pitti RM Marsters SA Ruppert S Donahue CJ Moore A Ashkenazi A Induction of apoptosis by Apo-2 Ligand, a new member of the tumor necrosis factor receptor family.J Biol Chem. 1996; 271: 12697Google Scholar], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [[2]Wiley SR Schooley K Smolak PJ Din WS Huang CP Nicholl JK et al.Identification and characterization of a new member of the TNF family that induces apoptosis.Immunity. 1995; 3 (96111955): 673- ...
Tópico(s): NF-κB Signaling Pathways
1997 - Elsevier BV | Current Biology
Our Rangoon Correspondent, EDWARD KIRKPATRICK., Our Correspondent, AN OBSERVER., E. F., Y., EDWARD THRING., CHARLES H. MELDON.,
... Judicial Committee Of The Privy Council, March 21. Marsters V. Durst., LAW NOTICES(This Day, Wednesday, March ... Tuesday, March 21. Lord Chamberlain's Office, St. James's Palace, March 17.. Politics and Parliament: House ...
1876 - Gale Group | TDA
Scot A. Marsters, James P. Sheridan, Robert Pitti, Jennifer Brush, Audrey D. Goddard, Avi Ashkenazi,
The tumor necrosis factor (TNF) cytokine family regulates development and function of the immune system [1]. TNF is expressed primarily by activated lymphocytes and macrophages and induces gene transcription or apoptosis in target cells [2,3]. We have identified a novel relative of TNF that binds to the recently discovered, death-domain-containing receptor called Apo3 [4] (also known as DR3, WSL-1, TRAMP or LARD [5-9]). The Apo3 ligand (Apo3L) is a 249 amino-acid, type II transmembrane protein. The extracellular ...
Tópico(s): Immune Response and Inflammation
1998 - Elsevier BV | Current Biology
By Fred Emery Political Editor, By Our Political Editor, From Our Own Correspondent, From Nicholas Ashford, From David Cross, From Michael Leapman, By Donald Macintyre Labour Reporter, By Paul Routledge Labour Editor, By Our Crime Reporter, By a Staff Reporter, By Hugh Noyes Parliamentary Correspondent, By Our Political Correspondent, By Our Home Affairs Correspondent, From Diana Geddes Education Correspondent Loughborough, By Robin Young Consumer Affairs Correspondent, From Christopher Walker, By Michael Baily Transport Correspondent, From John Chartres, From Christopher Thomas Labour Reporter, From Our Correspondent, By Pat Healy Social Services Correspondent, By Pearce Wright Science Editor, Ronald Faux Lerwick, By Our Consumer Affairs Correspondent, From Patricia Clough, From Charles Hargrove, From Michael Binyon, By David Spanier Diplomatic Correspondent, From Peter Hazelhurst, Frnm Neil Kelly, From Charles Harrison, By Robert Fisk, From Michael Knipe, From David Watts, Dr Hugh Jolly, Peter Evans Home Affairs Correspondent, Paul Overy, John Higgins, Irving Wardle, Ned Chaillet, Stanley Reynolds, William Mann, Paul Griffiths, Barry Millington, By John Woodcock Cricket Correspondent, By Richard Streeton, By Peter West Rugby Correspondent, By Rex Bellamy Squash Rackets Correspondent, From Christopher Plumridge, By Michael Seely, by Angus Stewart, by Peter Hill, by Julie C. Buddy, by H. E. Lack, by Pauline Long, David Blake, Bernard Levin, PHS, Nicholas Faith, EDWARD M. McGIRR, , DAVID LANE, , USHA PRASHAR, , PATRICIA HEWITT, , EMILY THORNBERRY, , J. M. HAWKSWORTH, , GEOFFREY ROBINSON, , DAVID NICHOLS, , JAMES BARBER, , L. W. SLADE, , CORRELLI BARNETT, , ALLEN OF ABBEYDALE, , N. KURTI, , By Geraldine Norman Sale Room Correspondent, By Our Arts Reporter, J.E., By Annabel Ferriman, By Caroline Atkinson, Patricia Tisdall, By Peter Hill Industrial Correspondent, By Arthur Reed Air Correspondent, From Melvyn Westlake, By Edward Townsend, From Michael Hornsby, By David Blake Economics Correspondent, By Malcolm Brown, By Our Financial Staff, By Clifford Webb, By Kenneth Owen Technology Correspondent, COLIN DAURIS, , JAMES PRESTON, , BROOKE DAVIS, , F. N. MANNING, , BY THE FINANCIAL EDITOR, Paul Ellman, Paul Routledge, By Ray Maughan, By Victor Felstead, By Michael Clark, By Bryan Appleyard, Wallace Jackson Commodities Editor,
... Japan aiming to boost investment in Europe, Miln Marsters' shares suspended as Swedish group prepares bid, Dubai ...
1978 - Gale Group | TDA
Mitsuru Kubota, Kent J. Evans, Catherine A. Koerntgen, James C. Marsters,
... Kubota, Kent J. Evans, Catherine A. Koerntgen, and James C. Marsters Jr.Cite this: J. Am. Chem. Soc. 1978, ...
Tópico(s): Catalytic Processes in Materials Science
1978 - American Chemical Society | Journal of the American Chemical Society
By John Groser Political Staff, From Alan Hamilton Labour Staff Bournemouth, From Robert Fisk Belfast, From Fred Emery, From Paul Martin, By Michael Horsnell., By Pearce Wright Science Correspondent, From Denis Taylor, By a Staff Reporter, From Our Legal Correspondent Bath, From Our Correspondent, From Paul Routledge Labour Correspondent, By A Staff Reporter, Ronald Faux, By Our Education Correspondent, From Peter Evans Home Affairs Correspondent, By Our Social Services Correspondent, By Stewart Tendler, By Tim Devlin Education Correspondent, From Dan van der Vat, By a Chess Correspondent, From Peter Nichols, From Our Own Correspondent, By Our Political Editor, From Charles Hargrove, From Michael Knipe, From Michael Hornsby, From Peter Strafford, From David Bonavia, By John Woodcock Cricket Correspondent, By Peter Marson, By Peter Ryde Golf Correspondent, By Geoffrey Green Football Correspondent, By John Downie, From Sydney Friskin, By Our Real Tennis Correspondent, From John Blunsden, By Neil Allen Athletics Correspondent, By Andrew Porter, From Rex Bellamy Tennis Correspondent, By Jim Railton, From Pierre Guillot French Racing Correspondents, By Michael Phillips Racing Correspondent, By Pamela Macgregor-Morris, Victoria Brittain, Jane Rendel, Pat Healy, Gerald Ely, By Peter Ambrose, By Robin Page, Ray Gosling, Stanley Reynolds, Joan Chissell, Stanley Sadie, Stephen Walsh, Alan Blyth, by Leonard Amey Agricultural Correspondent, by Sir Emrys Jones principal, Royal Agricultural College, by Mary Cherry, by Kenneth Woodford director, the Grassland, by Derek Watson, Lord Chalfont, Christopher Walker, Tim Jones, PHS, Elizabeth Young, David Wood, SEEBOHM, KEITH BROWN., WILLIAM DOUGLAS-HOME., JOHN DUNCAN MILLER., MICHAEL HAMLYN, , GARETH DANIEL., MICHAEL SOOLE., DAVID SOSKIN., RICHARD PYNE., JERRY FITZPATRICK., P. FLYNN, , ALEC BISHOP., HARRY KIDD., D. M. J. GWINNELL, , L. HOBDAY., ROGER J. HOWES., JOHN J. K. BEST-SHAW., By Clifford Longley Religious Affairs Correspondent, Leonard Amey, From our US Economics Correspondent, From John Earle, By Michael Baily Shipping Correspondent, By Hugh Clayton, By Andrew Wilson, By Roger Vielvoye Energy Correspondent, From Frank Vogl, By Our Energy Correspondent, By Kenneth Owen Technology Correspondent, Edited by Rodney Cowton, RC, Thomas Kempner, Innis Macbeath, DAVID WISE, J. R. B. LLOYD, , JOHN WEBB., C. PRINGLE, , BY THE FINANCIAL EDITOR, Hugh Stephenson, Margaret Drummond, Edward Townsend, By Ralph Holder, Terry Byland, Christopher Wilkins, By John Woodland, by Philip Greer, by George W. Ball, by Henry Kaufman, by Gabriel Hauge, by Leon Levy, by Christopher D. Illick, by John E. Leslie, by Myron Kandel, by James W. Michaels, by Barbara A. Patocka,
... Save & Prosper Group, John Deere Ltd, The Miln Marsters Group Limited., Ici, Northwood Publications Ltd, Family Circle ...
1974 - Gale Group | TDA
Teddy G. Traylor, James C. Marsters, Taku Nakano, Beth E. Dunlap,
... of iron(III) porphyrin catalyzed epoxidationsTeddy G. Traylor, James C. Marsters Jr., Taku Nakano, and Beth E. DunlapCite this: ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
1985 - American Chemical Society | Journal of the American Chemical Society
Michael Blaber, Paul J. Isackson, James C. Marsters, John P. Burnier, Ralph Bradshaw,
... the mouse submandibular glandMichael Blaber, Paul J. Isackson, James C. Marsters, Jr., John P. Burnier, and Ralph A. BradshawCite ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
1989 - American Chemical Society | Biochemistry
Karen A. Jongeward, Douglas Magde, Douglas J. Taube, James C. Marsters, Teddy G. Traylor, Vijay S. Sharma,
... isocyanidesKaren A. Jongeward, Douglas. Magde, Douglas J. Taube, James C. Marsters, Teddy G. Traylor, and Vijay S. SharmaCite this: ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
1988 - American Chemical Society | Journal of the American Chemical Society
Kirk Robarge, Shirley A. Brunton, Georgette M. Castanedo, Yong Cui, Michael S. Dina, Richard Goldsmith, Stephen E. Gould, Oivin Guichert, Janet L. Gunzner, Jason Halladay, Wei Jia, Cyrus Khojasteh, Michael F. T. Koehler, Karen Kotkow, Hank La, Rebecca Lyn LaLonde, Kevin Lau, Leslie Lee, Derek Marshall, James C. Marsters, Lesley Murray, Changgeng Qian, Lee L. Rubin, Laurent Salphati, Mark Stanley, J. H. A. STIBBARD, Daniel P. Sutherlin, Savita Ubhayaker, Shumei Wang, Susan Wong, Minli Xie,
... L. LaLonde , Kevin Lau , Leslie Lee , Derek Marshall , James C. Marsters Jr. , Lesley J. Murray , Changgeng Qian , Lee L. ...
Tópico(s): Hedgehog Signaling Pathway Studies
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
... character of Spike through meanings attached to actor James Marsters as a ‘subcultural celebrity’. Work on TV’s ...
Tópico(s): Gender, Feminism, and Media
2005 - SAGE Publishing | European Journal of Cultural Studies
... article explores the way in which the actor, James Marsters, performs the character of Spike. Beginning with the ...
Tópico(s): Narrative Theory and Analysis
2005 - SAGE Publishing | European Journal of Cultural Studies
Michael S. Brown, Joseph L. Goldstein,
... Full Text PDF PubMed Scopus (286) Google Scholar). James Marsters and his colleagues at Genentech designed a series ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2012 - Elsevier BV | Journal of Biological Chemistry
Regan G. Shea, James C. Marsters, Norbert Bischofberger,
Triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (2) was coupled to the 5' terminus of oligodeoxynucleotides via hydrogen phosphonate solid support DNA synthesis methodology. Duplex DNA oligomers with a single 5'-phospholipid melted at lower temperatures than the corresponding unmodified duplex, but duplexes bearing lipids at each 5' end had higher Tms. In uptake experiments with L929 cells, 8-10 times more lipid-DNA became cell-associated than did unmodified DNA. Unmodified antisense ...
Tópico(s): Advanced biosensing and bioanalysis techniques
1990 - Oxford University Press | Nucleic Acids Research
Karen A. Jongeward, James C. Marsters, Michael Mitchell, Douglas Magde, Vijay S. Sharma,
The kinetics of NO geminate recombination to sperm whale and elephant myoglobins has been studied on the picosecond time scale using an amplified colliding-pulse mode-locked ring dye laser. The dynamics of ligand rebinding are shown to be affected by the distal structure of the protein surrounding the heme pocket.
Tópico(s): Mass Spectrometry Techniques and Applications
1986 - Elsevier BV | Biochemical and Biophysical Research Communications
Kirk Robarge, Shirley A. Brunton, Georgette M. Castanedo, Yong Cui, Michael S. Dina, Richard Goldsmith, Stephen E. Gould, Oivin Guichert, Janet L. Gunzner, Jason Halladay, Wei Jia, Cyrus Khojasteh, Michael F. T. Koehler, Karen Kotkow, Hank La, Rebecca Lyn LaLonde, Kevin Lau, Leslie Lee, Derek Marshall, James C. Marsters, Lesley Murray, Changgeng Qian, Lee L. Rubin, Laurent Salphati, Mark Stanley, J. H. A. STIBBARD, Daniel P. Sutherlin, Savita Ubhayaker, Shumei Wang, Susan Wong, Minli Xie,
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the molecule resulting in 31 (GDC-0449). Amide 31 produced complete tumor regression at doses as low as 12.5 mg/kg BID in a medulloblastoma allograft mouse model that is wholly dependent on the Hh pathway for ...
Tópico(s): Ocular Disorders and Treatments
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Daniel D. Von Hoff, Patricia LoRusso, Charles M. Rudin, Josina C. Reddy, Robert L. Yauch, Raoul Tibes, Glen J. Weiss, Mitesh J. Borad, Christine L. Hann, Julie R. Brahmer, Howard Mackey, B. Lum, Walter C. Darbonne, James C. Marsters, Frédéric J. de Sauvage, Jennifer A. Low,
Mutations in hedgehog pathway genes, primarily genes encoding patched homologue 1 (PTCH1) and smoothened homologue (SMO), occur in basal-cell carcinoma. In a phase 1 clinical trial, we assessed the safety and pharmacokinetics of GDC-0449, a small-molecule inhibitor of SMO, and responses of metastatic or locally advanced basal-cell carcinoma to the drug.
Tópico(s): Genetic and rare skin diseases.
2009 - Massachusetts Medical Society | New England Journal of Medicine
Harvey Wong, J.Z. Chen, Bilin Chou, Jason Halladay, Jane R. Kenny, Hanson La, James C. Marsters, Emile G. Plise, Patrick J. Rudewicz, Kirk Robarge, Young G. Shin, Susan Wong, Chen Zhang, S. Cyrus Khojasteh,
GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide) is a potent, selective Hedgehog (Hh) signalling pathway inhibitor being developed for the treatment of various cancers. The in vivo clearance of GDC-0449 was estimated to be 23.0, 4.65, 0.338, and 19.3 ml min(-1) kg(-1) in mouse, rat, dog and monkeys, respectively. The volume of distribution ranged from 0.490 in rats to 1.68 l kg(-1) in mice. Oral bioavailability ranged from 13% in monkeys to 53% in dogs. Predicted ...
Tópico(s): Hedgehog Signaling Pathway Studies
2009 - Taylor & Francis | Xenobiotica
John T. Stults, James C. Marsters, Steven A. Carr,
Abstract A method is described for rapid purification of synthetic oligodeoxynucleotides to remove sodium counter ions prior to electrospray ionization mass spectrometry. The oligomers, following purification by gel electrophoresis, are precipitated from ammonium acetate to replace sodium ions by ammonium ions, and dissolved in water. Negative‐ion electrospray spectra are presented for oligomers with up to 48 residues in which the most intense peaks correspond to the [MnH] n − ion. The spectrum of ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
1991 - Wiley | Rapid Communications in Mass Spectrometry
M S Brown, Joseph L. Goldstein, Kenneth J. Paris, John P. Burnier, James C. Marsters,
Protein farnesyltransferase from rat brain transfers farnesyl residues to cysteine residues in tetrapeptides that conform to the sequence CA1A2X, where C is cysteine, A1 and A2 are aliphatic amino acids, and X is methionine or serine. When the A2 residue is aromatic [e.g., phenylalanine as in Cys-Val-Phe-Met (CVFM)], the tetrapeptide continues to bind to the enzyme, but it can no longer accept a farnesyl group, and it becomes a pure inhibitor. The current studies show that this resistance to farnesylation ...
Tópico(s): S100 Proteins and Annexins
1992 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Georgette M. Castanedo, Fredrick C. Sailes, N. Dubree, John B. Nicholas, Lisa D. Caris, Kevin Clark, Susan M. Keating, Maureen H. Beresini, Henry Chiu, Sherman Fong, James C. Marsters, David Y. Jackson, Daniel P. Sutherlin,
Two structural classes of dual alpha4beta1/alpha4beta7 integrin antagonists were investigated via solid-phase parallel synthesis. Using an acylated amino acid backbone, lead compounds containing biphenylalanine or tyrosine carbamate scaffolds were optimized for inhibition of alpha4beta1/VCAM and alpha4beta7/MAdCAM. A comparison of the structure-activity relationships in the inhibition of the alpha4beta7/MAdCAM interaction for substituted amines employed in both scaffolds suggests a similar binding ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2002 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
N. Dubree, Dean R. Artis, Georgette M. Castanedo, James C. Marsters, Daniel P. Sutherlin, Lisa D. Caris, Kevin Clark, Susan M. Keating, Maureen H. Beresini, Henry Chiu, Sherman Fong, Henry B. Lowman, Nicholas J. Skelton, David Y. Jackson,
The accumulation of leukocytes in various tissues contributes to the pathogenesis of numerous human autoimmune diseases. The integrin alpha4beta7, expressed on the surface of B and T lymphocytes, plays an essential role in lymphocyte trafficking throughout the gastrointestinal (GI) tract via interaction with its primary ligand, mucosal addressin cell adhesion molecule (MAdCAM). Elevated MAdCAM expression in the intestines and liver has been linked to GI-associated autoimmune disorders, including Crohn' ...
Tópico(s): Galectins and Cancer Biology
2002 - American Chemical Society | Journal of Medicinal Chemistry
David Arnott, Adrianne Kishiyama, Elizabeth Luis, Sarah G. Ludlum, James C. Marsters, John T. Stults,
A method has been developed, called the mass western experiment in analogy to the Western blot, to detect the presence of specific proteins in complex mixtures without the need for antibodies. Proteins are identified with high sensitivity and selectivity, and their abundances are compared between samples. Membrane protein extracts were labeled with custom isotope-coded affinity tag reagents and digested, and the labeled peptides were analyzed by liquid chromatography-tandem mass spectrometry. Ions ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2002 - Elsevier BV | Molecular & Cellular Proteomics
Hans‐Peter Gerber, Ajay K. Malik, Gregg P. Solar, Daniel Sherman, Xiao Liang, Gloria Meng, Kyu Hong, James C. Marsters, Napoleone Ferrara,
Tópico(s): Axon Guidance and Neuronal Signaling
2002 - Nature Portfolio | Nature
Thomas R. Gadek, Daniel J. Burdick, Robert S. McDowell, Mark Stanley, James C. Marsters, K. J. Paris, D. A. OARE, Mark Reynolds, C. Ladner, Kimberly Zioncheck, W. P. Lee, Peter Gribling, Mark S. Dennis, Nicholas J. Skelton, Daniel B. Tumas, Kevin Clark, Susan M. Keating, Maureen H. Beresini, Jefferson Tilley, Leonard G. Presta, Sarah Bodary,
The protein-protein interaction between leukocyte functional antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) is critical to lymphocyte and immune system function. Here, we report on the transfer of the contiguous, nonlinear epitope of ICAM-1, responsible for its association with LFA-1, to a small-molecule framework. These LFA-1 antagonists bound LFA-1, blocked binding of ICAM-1, and inhibited a mixed lymphocyte reaction (MLR) with potency significantly greater than that of cyclosporine ...
Tópico(s): Immunotherapy and Immune Responses
2002 - American Association for the Advancement of Science | Science