Giles Smith, Andrew Robson, Janice Turner, Alyn Shipton, Robert Dewar, Cath Urquhart, Robert Cole, DJM, David Brown, Sarah Potter, Martin Birchall, Greg Hurst Political Correspondent, Peter Lansley, James Harding, Howard Somerset, Mark Souster, Alexandra Frean Education Editor, Steve Bird and Frances Gibb, Philip Howard, Hilary Finch, Camilla Cavendish, Christine Seib, David Chater, James Bone, Steve Bird and Dominic Kennedy, James Ducker, Elizabeth Judge, Carl Mortished, Will Pavia, Sam Marlowe, Wendy Ide, Helen Nugent and Matt Sandy, Kevin Eason, George Barbour, Ben Webster Transport Correspondent, Donald Hutera, Andrew Halford, Stewart Tendler Crime Correspondent, Tom Bawden, Steve Bird, J. A. T. Hamilton, Debra Craine, Angela Jameson Industrial Correspondent, Dalya Alberge Arts Correspondent, Richard Need, Canon Peter Townley, Anatole Kaletsky, Adam LeBor, Charles Bremner, Jonathan Richards, Sholto Byrnes, Tim Teeman, John Corbin, Hugo Rifkind, Angela Jameson, Russell Kempson, Oliver Kay, Michael J. Hendrie Astronomy Correspondent, Ross Clark, Sarah Vine, Lisa Armstrong, Mark Henderson Science Editor, Patrick Hosking Banking and Finance Editor, Tom Baldwin, Stuart Bolton, Rob Wright, Gabriel Rozenberg, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Ian Evans, Adam Sage, Matthew Pryor, Sean MacAulay, Peter Riddell Political Briefing, Gary Jacob and Rick Broadbent, Matt Dickinson, Anthony Gee, Philip Webster and Anthony Browne, Sarah Campbell, Councillor John Bale, Kim Righetti, Chris Campling, Bronwen Maddox, J D Manson, Sudi Pigott, Roger Boyes, David Mattin, Peter Dixon, Gabriel Rozenberg Economics Reporter, Nick Hasell, Small Caps, Ned Parker, David Hands Rugby Correspondent, Tom Dart, Rosemary Bennett Social Affairs Correspondent, Julian Muscat, Paul Simons, Kevin Maher, Desmond Hartley, Nick Szczepanik, John Goodbody, Anthony Bush, Mary Ann Sieghart, Ian Johns, Liam Barlow, Matthew Parris, Graham Searjeant Financial Editor, Thomas Catan, Anjana Ahuja, George Caulkin, Ben Hoyle and Marcus Leroux, Alan Lee, Tim Reid and Tom Baldwin, Gaurav Upadhyay, Carly Chynoweth, Tom Hennigan, Michael Morgan, Geoffrey Podger, Sir John Donne, Lewis Smith Environment Reporter, Michael Horsnell, Mark Henderson, Martin Waller, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Angus Batey, Dr Thomas Stuttaford, Stephen Dalton, Bill Edgar, Frances Gibb, Tony Halpin, Hugh Tonks, Antony Moore, Steve Hemsley, Ann Treneman Conference Sketch, Clare Dight, Olav Bjortomt, David Robertson, Jane Macartney,
... died on August 30, 2006, aged 70 Professor James H. Whitelaw, engineer, was born on January 28,1936. He died on August 16,2006, aged 70 General Micheal Poulet, soldier, was born on August 2,1948. He ...
2006 - Gale Group | TDA
Thomas Müller, Stephanie Braud, René Jüttner, Birgit C. Voigt, Katharina Paulick, Maria E. Sheean, Constantin Klisch, Dilansu Gueneykaya, Fritz G. Rathjen, Jörg Geiger, James F.A. Poulet, Carmen Birchmeier,
... for more papers by this author James FA Poulet James FA Poulet orcid.org/0000-0003-0296-5415 ... for more papers by this author James FA Poulet James FA Poulet orcid.org/0000-0003-0296-5415 Neural Circuits ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2018 - Springer Nature | The EMBO Journal
Richard Buckle, James Margach, Steven Hamilton, Elizabeth Nicholas, Nicholas Carroll Diplomatic Correspondent, J W Popplestone, Christopher Kavanagh, Elizabeth Owen-John, Harold Hobson, B D Chapman, P. C. Asbury-Smith, Ian Peebles, Tom Margerison Science Editor, J. W. Lambert, Antony Terry, Josephine Fenton, Gavin Lyall, (Mrs) Rosemary Crawley, Moira Keenan, Julian Symons, Frederic Raphael, Richard Oldfield Chairman, Henry Brandon, John Russell, Elizabeth Gundrey, Derek Jewell, John Prizeman, Vivian Jenkins, George Thomas, James Stuart, Edmund Stevens, C Bewicke (Major), C W K Mundle Department of Philosophy University College, Frank Giles, Peter Willett, Robin Marlar, Hugh Somerville, Cyril Connolly, J P Jackson, Colonel David Smiley, Raymond Mortimer, Maxwell Boyd, John Ivey, Evelyn Irons, Audrey Powell, J C Colligan Director-General, Stephen Bradford, Peter Wilsher, Susan Noel, William Rees-Mogg Economic and Political Editor, Jacques Marcuse, Roger Mortimer, Anthony Vice City Editor, Ronald Hingley, Ernestine Carter, Sir Harold Roxbee Cox, Desmond Shawe-Taylor, Peter Mansfield, P V F Cazalet (Major), Nicholas Wollaston, R. C. Robertson-Glasgow, Mr. H. M. F. Carrington, Lanning Roper, H Montgomery Hyde, Dilys Powell, H S, Ann Crowe, Gerald Pawle, Richard Hughes, Rev. Dr. Leslie D. Weatherhead, Robert Carrier, Felix Aprahamian, A. V., David Leitch, Sir Edwin Herbert's, Michael Ratcliffe, Ian Coulter Industrial Correspondent, Henry Longhurst, Pamela Hansford Johnson, James Margach Political Correspondent, Hunter Davies, Harold Fielding, Brian Glanville, Anthony Houghton, Robert Harbinson, C. H. O'd. Alexander, Maurice Wiggin, Atticus, Robert Harling, Margaret Wright, D. S. T., Julian Mitchell, Kenneth Konstam,
... Left: ribbed sheet linoleum from Italy. Hard-wearing Poulet Sauté Great Dishes of the World Poulet Sauté Borra An advertisement carried in the Sunday ...
1963 - Gale Group | Sunday Times HA GDA
Julia Ojeda‐Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos, Rakesh Kumar, Ming-Dong Zhang, James F.A. Poulet, Patrik Ernfors, Gary R. Lewin,
Abstract Previous work identified nociceptive Schwann cells that can initiate pain. Consistent with the existence of inherently mechanosensitive sensory Schwann cells, we found that in mice, the mechanosensory function of almost all nociceptors, including those signaling fast pain, were dependent on sensory Schwann cells. In polymodal nociceptors, sensory Schwann cells signal mechanical, but not cold or heat pain. Terminal Schwann cells also surround mechanoreceptor nerve-endings within the Meissner’ ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2024 - Nature Portfolio | Nature Communications
Sara Stocks, Stewart Tendler and Michael Harvey, Jon Ashworth, Helen Johnstone, Tom Foster, Andrew Pierce, C. A. Last, Grace Bradberry, Jane MacQuitty, John Morgan, Jill Hartley, Andrew Morgan, Valerie Elliott and Nick Nuttall, Tony Johnson, Paul Hoggart, Martin Richards, Richard Hobson, Ivo Tennant, Gavin Lumsden, Kasha Harmer Hirst, Giles Wood, Jestyn Philips, Philip Howard, Caroline Merrell, Banking Correspondent, Michael Binyon, Jeremy Kingston, James Bone, David Stokes, Alison Kervin, Clive Davis, Alexandra Frean Social Affairs Correspondent, Kate Reardon, Malcolm Higgins, Elizabeth Judge, Carl Mortished, Martin Fletcher, European Correspondent, Harding Dunnett (Founder and Chairman), Anne Robinson, Martin Aston, heath brown, Sylvia Crookes, Richard Miles and Paula Hawkins, Tim Marsh, Tony Patrick, Kevin Eason, Amon Cohen, Clare Stewart, Mitchel Jenkins, Matthew Leigh, John Thicknesse, Berkeley Hill, Pat Gibson, Paul Fitzpatrick, Tish McPhilemy, Philip Webster and Tom Baldwin, Robert Sheehan, Hilary Rose, Michael J. Wolf Penguin, Marcelle d'Argy Smith, Mary Flowers, Steve Keenan, John Hopkins, Golf Correspondent, D. R., Max Stahl, Dominic Walsh, Ruth Gledhill, Shirley English, John O'leary, Education Editor, Rob Penn, Alix Ramsay Tennis Correspondent, Michael Lane, Tim Reid, T. Sales, Martin Barrow, Eric Idle, Candida Crewe, Jo Morris, Robin Young, Mark Inglefield, Robin Young and Tim Jones, Ian Murray, Medical Correspondent, James Landale and Tom Baldwin, Jenny MacArthur, George Lees, JK, T. P., Michael Pinto-Duschinsky, Eileen Orr, Frances Bissell, Mike Bradley, David Hands, P. B., Charles Bremner, Michael Cable, Helen Rumbelow, Alan Lee, Racing Correspondent, Peter Barnard, Anthea Lawson, Tim Teeman, Caroline Merrell Banking Correspondent, Derwent May, Mary Loudon, Rodney Miles, peter zownir, Ben Reed, Dave Haslam, Russell Kempson, Paula Hawkins, Linda Galloway, Ed Potton, Paul Armstrong, Richard Colwill, Stephen Anderton, June Osborne, Amber Cowan, Lisa Grainger, David Lister, George Brock, Frank Leboeuf, Liz Bird, Christopher Martin-Jenkins, Ian Adcock, L. G., Kurt Anderson, Dave Thomas, Mike Thomas, Geoffrey Dean, Rob Wright, R. D. Farrant, Stephen Wood, David Watts, David Powell Athletics Correspondent, Raymond Keene, David Robinson, Clive Mathieson, John Russell Taylor, Alexander Muir, Tom Baldwin, Deputy Political Editor, James Allcock, Sean Hignett, David Lister and James Bone, Nigel Hawkes, Clive Petty, Caroline Merrell, Min Cooper, Christopher Walker Chief Ireland Correspondent, Oliver Holt, Richard Owen, David Kettle, Sarah Cunningham, Nigel Hawkes, Science Editor, Caryl Brahms and S. Simon Black Swan, Sarah Litvinoff, John Stern, John diamond, Brian Hammond, Stephanie Billen, Celestria Noel, Alison Kervin, Rugby Editor, Adam Fresco, Helen Jones, Philip Lowe, Nick Szczepanik, Richard Miles and Sally Patten, Anne Ashworth, Ted Ditchburn, Giles Whittell, Charlie Pinney, nigel williamson, Saeed Shah, Jason Nissé, Mel Webb, Leeyson M. James, Deborah King, Matthew Parris, Lisa See Arrow, George Caulkin, Chris McGrath, Tim Wapshott, Russell Jenkins, Clarissa Hyman, Alan Lee, Jane Owen, Ben MacIntyre, A. J. Tipping, Ian Brodie, Owen Harris, Ben Macintyre, Richard Miles, David Sinclair, Fraser Nelson, John Naish, Michael Binyon, Diplomatic Editor, Anne Ashworth Personal Finance Editor, JRT, Michael Horsnell, Peter Ingham, Lisa Verrico, Nigel Hawkes Science Editor, Lottie Moggach, Mark Baldwin, Christopher Andrew, Benedict Nightingale, Stuart Birch, Jonathan Meades, Jill Crawshaw, Frances Gibb Legal Correspondent, Patricia Duce, David Ogilvy, Chairman, Alyson Rudd, Sam Kiley, Jack Bailey, Tom Chesshyre, Fred Dellar, Valerie Grove, Paul Connolly, Rupert Thomson, Allan Hall, Matt Ridley, Penny Perrick, Lea Paterson Economics Correspondent, Cath Urquhart Travel Editor, Peter Roebuck, David Hands, Rugby Correspondent, Henrietta Lake, Philip M. Gilbert, Christopher Irvine, Michael Barnard, Harris (Vice-Chairman), Rebecca Goldsmith, Susan Emmett,
... Interests Feta Cheese More Foot & Drink The Perfect Poulet a La Basquaise Drink Bordeaux has taken a ...
1999 - Gale Group | TDA
Y. Zhang, Ali Karrech, Peter Schaubs, Klaus Regenauer‐Lieb, Thomas Poulet, James S. Cleverley,
Abstract This study simulates rock deformation around high temperature granite intrusions and explores how gold bearing shear zones near intrusions were developed in the Yilgarn, using a new continuum damage mechanics algorithm that considers the temperature and time dependent elastic-visco-plastic constitutive behaviour of crustal materials. The results demonstrate that strain rates have the most significant effects on structural patterns for both extensional and compressional cases. Smaller strain ...
Tópico(s): High-pressure geophysics and materials
2011 - Elsevier BV | Tectonophysics
BARRISTER-AT-LAW., The Secretary of the Coal Association, JOHN C. CURTISS, , SYDENHAM., CHARLES MARKHAM., ANEURIN WILLIAMS., G. H. COLOMB, , E. GRAYDON STANNUS., GEOFFREY C. HOBBS., C. A.G. B., SIMPLEX., S., G. T., G. A. ANSON., BLEDISLOE, WILLIAM DEEDES., GREY OF FALLODON., A Correspondent,
... Export Of Marks., French Airmen's Ill-Luck. Poulet's Interrupted Flight., Prisoners From Russia. First Arrivals ...
1920 - Gale Group | TDA
Cédric Trolliet, Guillaume Poulet, A. Tuel, James D. Wuest, Philippe Sautet,
Molecules with multiple sites of hydrogen bonding attached to suitable cores tend to crystallize as open networks. The resulting crystals can have the following unusual properties: They can include significant amounts of guest molecules; the guests are typically located in channels and can be exchanged without loss of crystallinity; and the geometry of the networks can change in response to new guests. We have found that DFT calculations can provide accurate simulations of the unusual structure ...
Tópico(s): Surface Chemistry and Catalysis
2007 - American Chemical Society | Journal of the American Chemical Society
Geoffrey Chandler, Kenneth Pickthorn, Oliver J. Keller, S. Kumarasundaram, J. Rawson Gardiner, James Tinn,
... Complete Accounting \ Control Lotus Shoes Godfrey Phillips Limited Poulet Rideau de Fer Health in Industry Cheaper Nylons ...
1951 - Gale Group | The Economist
Christopher Maniglier-Poulet, Xiaoqin Cheng, James A. Ruth, David Ross,
1,3-Butadiene (BD), a gas used in the production of rubber and plastics, induces a high incidence of leukemias and lymphomas in B6C3F1 mice. Because of the potential involvement of the hematopoietic system in response to BD, we have examined metabolism of BD by B6C3F1 mouse and human bone marrow and by purified human myeloperoxidase (MPO), an enzyme rich in bone marrow. BD was metabolized to butadiene monoxide (BMO) by MPO and by mouse and human bone marrow cells. In all of these systems metabolism ...
Tópico(s): Indoor Air Quality and Microbial Exposure
1995 - Elsevier BV | Chemico-Biological Interactions
Spencer Ponsonry, W. B. Donne, G. Poulet Scrope F. R. S., Thompson Hankey, Effingham Wilson, E. P. Hingston Manager,
... Shah Court of Probate and Divorce (Before Sir James Hannen and a special Jury) A Singular Will ...
1873 - Gale Group | Sunday Times HA GDA
Bowen Dempsey, Selvee Sungeelee, Phillip Bokiniec, Zoubida Chettouh, Séverine Diem, Sandra Autran, Evan R. Harrell, James F.A. Poulet, Carmen Birchmeier, Harry Carey, Auguste Genovesio, Simon McMullan, Christo Goridis, Gilles Fortin, Jean‐François Brunet,
Abstract It has long been known that orofacial movements for feeding can be triggered, coordinated, and often rhythmically organized at the level of the brainstem, without input from higher centers. We uncover two nuclei that can organize the movements for ingesting fluids in mice. These neuronal groups, IRt Phox2b and Peri5 Atoh1 , are marked by expression of the pan-autonomic homeobox gene Phox2b and are located, respectively, in the intermediate reticular formation of the medulla and around the ...
Tópico(s): Pancreatic function and diabetes
2021 - Nature Portfolio | Nature Communications
M. Bouley, M. Brémond, Dr. Jules Bergeron, W. H. Dickenson, Dr. R. Lépine, Dr. C. Méhu, James Andrew, S. Lilienthal, M. Krishaber, Charles Bland Radcliffe, Professor A. Kussmaul, Professor R. Maier, William T. Aitken, Sir William Gull, Charles Murchison, M. Cornil, A. C. C. De Renzy, M. Chauffard, B. M. Cromwell, Professor Maurice Perrin, Henry Adams, Francis D. Condie, M. E. Webb, F. T. Roberts, Reginald Southey, William Smart, Austin Flint, S. Weir Mitchell, S. M. Bradley, Francis E. Anstie, T. S. Clouston, M. Charcot, James Broadbent, J. Lockhart Clarke, M. Bourdon, H. C. Wood Jr., John A. Lidell, E. Brand, F. W. Bartlett, A. Ransome, M. Roger, Francis E. Anstie, Sir Thomas Watson, J. M. Winn, Richard Payne Cotton, Walter Hayle Walshe, Dr. R. Lépine, James H. Hutchinson, Leartus Connor, S. M. Bradley, Benjamin W. Richardson, Bradford S. Thompson, J. E. Nichols, Harrison Allen, Dr. E. Cyon, Dr. W. Muller, Gueneau De Mussy, John W. Ogle, Balthazar Foster, Sir William Gull, Henry G. Sutton, Leonidas Crews, J. McCall Anderson, Henry Samuel Purdon, Robert Munro, J. McCall Anderson, William Ingalls, J. McCall Anderson, M. Poulet, E. A. Anderson, J. Daniel Moore, T. Janeway, M. Oré, Hasford Walker, R. D. Bone, Thomas Fraser, J. Magee Finny, Professor Ludwig Meyer, J. P. Brown, John Dougall, L. B. Kline, J. Wilkie Burman, M. Adrian, Judson B. Andrews, M. Bouchut, M. Bitot, E. Peugnet, Henry M. F. Newton, E. D. Worthington, William A. Hammond, Henry Hartshorne, H. G. Howse, Andrew H. Smith, J. H. Bill, M. Gimbert, H. M. Morgan, Benjamin Lee, H. Parvin, Lawrence Turnbull, David Webster, Alexander Edward McRae, Alfred L. Carroll, S. Radziejewski, Benjamin W. Richardson, George M. Beard, Charles Kidd, Henry Thompson, Julius Althaus, George F. Elliott, Charles R. C. Tichborne, Alonzo L. Leach, H. P. Bowditch, T. Spencer Cobbold, James T. George, T. Holmes, Campbell De Morgan, S. Weir Mitchell, M. Verneuil, Thomas M. Markoe, William Acton, Philip Cowen, Thomas Bryant, M. Féréol, John Wood, Henry Power, H. Althof, C. Bell Taylor, Charles Bader, James Martin, M. Warlomont, J. H. Hollister, R. Liebreich, Prof. Hermann Schmidt, J. J. Chisolm, Archibald Hamilton Jacob, Henry Power, Dr. Jos. Gruber, W. B. Dalby, W. B. Dalby, W. B. Dalby, W. B. Dalby, Charles Warden, H. Knapp, Christopher Heath, C. E. Wright, William R. McMahon, J. H. Raymond, Dr. Emanuel Kohn, Gustave A. Shane, Robert Newman, M. A. Muron, Sir James Paget, M. Gosselin, T. Spencer Wells, T. Spencer Wells, Richard T. Tracy, Evory Kennedy, Washington L. Atlee, Henry Horton, S. M. Bradley, H. B. Davidson, James R. Lane, Gurdon Buck, H. Guersant, John Ashhurst Jr., J. Watelet, Fordyce Barker, William Allingham, J. Fayrer, P. J. Hayes, J. H. Raymond, M. Ollier, W. F. Peck, M. Simon Duplay, Samuel Logan, Geo. Southam, W. W. Keen, William MacCormac, T. Curtis, D. De. Berdt Hovell, Henry Finch, C. F. Maunder, Benjamin Blower, E. M. Moore, M. Simon Duplay, Thomas More Madden, Professor Hermann Lebert, Alfred Meadows, Professor C. Henning, E. Montgomery, Sir James Y. Simpson, Sir W. G. Simpson, Dr. Wilhelm Pfannkuch, H. Plummer, James R. Chadwick, T. J. Hutton, D. Dyce Brown, W. H. Campbell, Evory Kennedy, James H. Aveling, Theodore Keller, M. Hervieux, T. Spencer Wells, Evory Kennedy, Evory Kennedy, Heywood Smith, Thomas Chambers, A. R. Simpson, John Clay, Dr. Joseph Pollak, Protheroe Smith, George H. Kidd, Charles R. Drysdale, Evory Kennedy, Charles R. Drysdale, Edward Montgomery, G. F. Miller, Joseph R. Beck, G. P. Hachenberg, Evory Kennedy, A. B. Steele, William F. Jenks, Snow Beck, James L. Brown, James L. Brown, J. Henry Bennet, M. A. D'Espine, D. M. Clay, Charles R. Drysdale, Chas. R. Drysdale, John Brunton, W. H. Day, Dr. Karl Lorey, Brynbery Porter, Daniel MacLean, F. King, John S. Parry, John O'Reilly, C. S. Kittredge, Dr. I. Bierbaum, Dr. Alois Monti, Haynes Walton, Henry Hartshorne,
Frontmatter: Philadelphia: Collins, Printer, 705 Jayne Street, The Half-Yearly Abstract of the Medical Sciences, Half-Yearly Abstract of the Medical Sciences, ...
1873 - Gale Group | NCCO-STM 1of2
Caroline Berlage, Malinda L. S. Tantirigama, Mathias Babot, Diego Di Battista, Clarissa J. Whitmire, Ioannis N. Papadopoulos, James F.A. Poulet, Matthew E. Larkum, Benjamin Judkewitz,
Optical imaging techniques are widely used in biological research, but their penetration depth is limited by tissue scattering. Wavefront shaping techniques are able to overcome this problem in principle, but are often slow, and their performance depends on the sample. This greatly reduces their practicability for biological applications. Here we present a scattering compensation technique based on three-photon excitation, which converges faster than comparable two-photon (2P) techniques and works ...
Tópico(s): Optical Coherence Tomography Applications
2021 - Optica Publishing Group | Optica
Fred Schwaller, Valérie Bégay, Gema García‐García, Francisco J. Taberner, Rabih Moshourab, Brennan McDonald, Trevor Docter, Johannes Kühnemund, Julia Ojeda‐Alonso, Ricardo Paricio-Montesinos, Stefan G. Lechner, James F.A. Poulet, José M. Millán, Gary R. Lewin,
Fingertip mechanoreceptors comprise sensory neuron endings together with specialized skin cells that form the end-organ. Exquisitely sensitive, vibration-sensing neurons are associated with Meissner's corpuscles in the skin. In the present study, we found that USH2A, a transmembrane protein with a very large extracellular domain, was found in terminal Schwann cells within Meissner's corpuscles. Pathogenic USH2A mutations cause Usher's syndrome, associated with hearing loss and visual impairment. ...
Tópico(s): Tactile and Sensory Interactions
2020 - Nature Portfolio | Nature Neuroscience
Ioannis N. Papadopoulos, Jean-Sébastien Jouhanneau, Naoya Takahashi, David Kaplan, Matthew E. Larkum, James F.A. Poulet, Benjamin Judkewitz,
Abstract Optical microscopy is an indispensable tool in biomedical sciences, but its reach in deep tissues is limited due to aberrations and scattering. This problem can be overcome by wavefront-shaping techniques, albeit at limited fields of view (FOVs). Inspired by astronomical imaging, conjugate wavefront shaping can lead to an increased field of view in microscopy, but this correction is limited to a set depth and cannot be dynamically adapted. Here, we present a conjugate wavefront-shaping scheme ...
Tópico(s): Optical Coherence Tomography Applications
2020 - Springer Nature | Light Science & Applications
Ricardo Paricio-Montesinos, Frederick Schwaller, Annapoorani Udhayachandran, Florian Rau, Jan Walcher, Roberta Evangelista, Joris Vriens, Thomas Voets, James F.A. Poulet, Gary R. Lewin,
Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1: ...
Tópico(s): Neurobiology and Insect Physiology Research
2020 - Cell Press | Neuron
James F.A. Poulet, Sylvain Crochet,
Cortical neurons process information on a background of spontaneous, ongoing activity with distinct spatiotemporal profiles defining different cortical states. During wakefulness, cortical states alter constantly in relation to behavioral context, attentional level or general motor activity. In this review, we will discuss our current understanding of cortical states in awake rodents, how they are controlled, their impact on sensory processing, and highlight areas for future research. A common observation ...
Tópico(s): Photoreceptor and optogenetics research
2019 - Frontiers Media | Frontiers in Systems Neuroscience
Jean-Sébastien Jouhanneau, James F.A. Poulet,
Although we know a great deal about monosynaptic connectivity, transmission and integration in the mammalian nervous system from in vitro studies, very little is known in vivo. This is partly because it is technically difficult to evoke action potentials and simultaneously record small amplitude subthreshold responses in closely (< 150 µm) located pairs of neurons. To address this, we have developed in vivo two-photon targeted multiple (2 – 4) whole-cell patch clamp recordings of nearby neurons in superficial ...
Tópico(s): Neuroscience and Neural Engineering
2019 - Frontiers Media | Frontiers in Synaptic Neuroscience
Phillip Bokiniec, Niccolò Zampieri, Gary R. Lewin, James F.A. Poulet,
Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific ‘labeled-lines’ to multimodal interactive pathways, the functional organization and identity of the neural circuits mediating innocuous thermal perception have been debated for over 100 years. Here we highlight ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2018 - Elsevier BV | Current Opinion in Neurobiology
Leiron Ferrarese, Jean-Sébastien Jouhanneau, Michiel W. H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet,
Excitatory synaptic input reaches the soma of a cortical excitatory pyramidal neuron via anatomically segregated apical and basal dendrites. In vivo, dendritic inputs are integrated during depolarized network activity, but how network activity affects apical and basal inputs is not understood. Using subcellular two-photon stimulation of Channelrhodopsin2-expressing layer 2/3 pyramidal neurons in somatosensory cortex, nucleus-specific thalamic optogenetic stimulation, and paired recordings, we show ...
Tópico(s): Neuroscience and Neural Engineering
2018 - Cell Press | Cell Reports
Jean-Sébastien Jouhanneau, Jens Kremkow, James F.A. Poulet,
Abstract A defining feature of cortical layer 2/3 excitatory neurons is their sparse activity, often firing in singlets of action potentials. Local inhibitory neurons are thought to play a major role in regulating sparseness, but which cell types are recruited by single excitatory synaptic inputs is unknown. Using multiple, targeted, in vivo whole-cell recordings, we show that single u EPSPs have little effect on the firing rates of excitatory neurons and somatostatin-expressing GABA-ergic inhibitory ...
Tópico(s): Neuroscience and Neural Engineering
2018 - Nature Portfolio | Nature Communications
Joanna Urban-Ciećko, Jean-Sébastien Jouhanneau, Stephanie E. Myal, James F.A. Poulet, Alison L. Barth,
Sleep, waking, locomotion, and attention are associated with cell-type-specific changes in neocortical activity. The effect of brain state on circuit output requires understanding of how neuromodulators influence specific neuronal classes and their synapses, with normal patterns of neuromodulator release from endogenous sources. We investigated the state-dependent modulation of a ubiquitous feedforward inhibitory motif in mouse sensory cortex, local pyramidal (Pyr) inputs onto somatostatin (SST)-expressing ...
Tópico(s): Receptor Mechanisms and Signaling
2018 - Cell Press | Neuron
Thomas Rathjen, Xin Yan, Natalia L. Kononenko, Min‐Chi Ku, Kun Song, Leiron Ferrarese, Valentina Tarallo, Dmytro Puchkov, Gaga Kochlamazashvili, Sebastian Brachs, Luis Varela, Klara Szigeti‐Buck, Chun‐Xia Yi, Sonja C. Schriever, Sudhir Gopal Tattikota, Anne Sophie Carlo, Mirko Moroni, Jan Siemens, Arnd Heuser, Louise van der Weyden, Andreas L. Birkenfeld, Thoralf Niendorf, James F.A. Poulet, Tamas L. Horváth, Matthias H. Tschöp, Matthias Heinig, Mirko Trajkovski, Volker Haucke, Matthew N. Poy,
Susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis. Genome-wide association studies have identified associations between body mass index and two loci near cell adhesion molecule 1 (CADM1) and cell adhesion molecule 2 (CADM2), which encode membrane proteins that mediate synaptic assembly. We found that these respective risk variants associate with increased CADM1 and CADM2 expression in the hypothalamus of human subjects. ...
Tópico(s): Regulation of Appetite and Obesity
2017 - Nature Portfolio | Nature Neuroscience
Luc Estebanez, Diana Hoffmann, Birgit C. Voigt, James F.A. Poulet,
The control of targeted reaching is thought to be shaped by distinct subtypes of local GABAergic inhibitory neurons in primary forelimb motor cortex (M1). However, little is known about their action potential firing dynamics during reaching. To address this, we recorded the activity of parvalbumin-expressing (PV+) GABAergic neurons identified from a larger population of fast-spiking units and putative excitatory regular-spiking units in layer 5 of the mouse forelimb M1 during an M1-dependent, sensory- ...
Tópico(s): Neuroscience and Neural Engineering
2017 - Cell Press | Cell Reports
Ioannis N. Papadopoulos, Jean-Sébastien Jouhanneau, James F.A. Poulet, Benjamin Judkewitz,
A long-standing goal in biomedical imaging, the control of light inside turbid media, requires knowledge of how the phase and amplitude of an illuminating wavefront are transformed as the electric field propagates inside a scattering sample onto a target plane. So far, it has proved challenging to non-invasively characterize the scattered optical wavefront inside a disordered medium. Here, we present a non-invasive scattering compensation method, termed F-SHARP, which allows us to measure the scattered ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2016 - Nature Portfolio | Nature Photonics
Wenjie Zhao, Jens Kremkow, James F.A. Poulet,
The synchronized activity of six layers of cortical neurons is critical for sensory perception and the control of voluntary behavior, but little is known about the synaptic mechanisms of cortical synchrony across layers in behaving animals. We made single and dual whole-cell recordings from the primary somatosensory forepaw cortex in awake mice and show that L2/3 and L5 excitatory neurons have layer-specific intrinsic properties and membrane potential dynamics that shape laminar-specific firing ...
Tópico(s): Photoreceptor and optogenetics research
2016 - Cell Press | Cell Reports
Christiane Wetzel, Simone Pifferi, Cristina Picci, Çağlar Gök, Diana Hoffmann, Kiran Kumar Bali, André Lampe, Liudmila Lapatsina, Raluca Fleischer, Ewan St. John Smith, Valérie Bégay, Mirko Moroni, Luc Estebanez, Johannes Kühnemund, Jan Walcher, Edgar Specker, Martin Neuenschwander, Jens Peter von Kries, Volker Haucke, Rohini Kuner, James F.A. Poulet, Jan Schmoranzer, Kate Poole, Gary R. Lewin,
The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in silencing touch receptors and reversed touch-evoked pain associated with nerve injury or diabetic neuropathy. The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements. Movement is ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2016 - Nature Portfolio | Nature Neuroscience
Claudia Böhm, Yangfan Peng, Nikolaus Maier, Jochen Winterer, James F.A. Poulet, Jörg R. P. Geiger, Dietmar Schmitz,
Cortical and hippocampal oscillations play a crucial role in the encoding, consolidation, and retrieval of memory. Sharp-wave associated ripples have been shown to be necessary for the consolidation of memory. During consolidation, information is transferred from the hippocampus to the neocortex. One of the structures at the interface between hippocampus and neocortex is the subiculum. It is therefore well suited to mediate the transfer and distribution of information from the hippocampus to other ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2015 - Society for Neuroscience | Journal of Neuroscience
Jean-Sébastien Jouhanneau, Jens Kremkow, Anja L. Dorrn, James F.A. Poulet,
Little is known about the properties of monosynaptic connections between identified neurons in vivo. We made multiple (two to four) two-photon targeted whole-cell recordings from neighboring layer 2 mouse somatosensory barrel cortex pyramidal neurons in vivo to investigate excitatory monosynaptic transmission in the hyperpolarized downstate. We report that pyramidal neurons form a sparsely connected (6.7% connectivity) network with an overrepresentation of bidirectional connections. The majority of ...
Tópico(s): Neuroscience and Neural Engineering
2015 - Cell Press | Cell Reports