Srikumar Sen, Boxing Correspondent, Tim Judah and James Bone, William Kingston, Phil Yates, David Tytler, DJM, Sheila Gunn, Anatol Lieven, Edward Gorman Ireland Correspondent, Rob Hughes, Simon Barnes, Sarah Bagnall, Insurance Correspondent, Neil Bennett, John Diamond, Ben Preston, Richard Ford, Home Affairs Correspondent, Philip Howard, William Waldegrave, John Wadham, Alexandra Frean Media Correspondent, Norman De Mesquita, Michael Binyon, Paul Rubens, Lynne Truss, Michael McCarthy, Colin Narbrough, Gerald Davies, Ray Clancy, Joe Joseph, David Ljunggren, Jeremy Laurance, Health Services Correspondent, Bryan Stiles, Howard Davies, Denis E. Filer, Peter Ball, Peter W. Heath, J. Bingham Dore, Raymond Keene Chess Correspondent, Louise Taylor, Ruth Gledhill Religion Correspondent, Ray Kennedy, John O'Leary, Keith Pike, Kevin Eason Motoring Correspondent, George Brock and Philip Webster, Edward Gorman, Fiona Pitt-Kethley, M. Eileen Magnello, Susan Gilchrist, Philip Webster, Jonathan Prynn, Jamie Dettmer and Richard Ford, Russell Kempson, Wolfgang MüNchau, R. Paine, Margot Norman, John Woodcock, Jamie Dettmer and Peter Victor, Martin Hoyle, David Miller, Barry Millington, Philip Webster, Chief Political Correspondent, David Powell Athletics Correspondent, George Sivell, City Editor, Nicholas Braslavsky, Alan Lee, Cricket Correspondent, Raymond Keene, Chess Correspondent, Mike Hollingsworth, Oliver Holt, Barry Pickthall, Neil Bennett and Sarah Bagnall, Brian Beel, David McMurray, Udi Eichler, David Hands Rugby Correspondent, Julian Muscat, David Napley, Carl Mortished and Michael Horsnell, William Rees-Mogg, Rawdon Crozier, Philip Webster Chief Political Correspondent, Mel Webb, Matthew Parris, A. D. C. Turner, Lewis J. Evans, Peter Riddell, Elizabeth Brown, Alastair Bruton, Tony Dawe, Richard Beeston, Melinda Wittstock, Tim Jones, Ben Lynfield, Kate Bassett, L. T. Bridges, Benedict Nightingale, Tom Rhodes, Paul B. Senior, John MacKay and Tiro Clarke, Sam Kiley, Michael Henderson, Anne McElvoy, Peter Robinson, Walter Ellis, Richard Ford, Christopher Irvine, Michael Evans Defence Correspondent and Tom Rhodes, Michael Hornsby Agriculture Correspondent,
Taxpayers foot Ira bomb bill MPs demand tighter security as Major fights to protect City's world reputation Ministers are wrestling with the problem of ...
1993 - Gale Group | TDA
Stephanie J. Klenotich, Mariel P. Seiglie, Matthew S. McMurray, Jamie D. Roitman, Daniel Le Grange, Priya Dugad, Stephanie C. Dulawa,
Anorexia nervosa (AN) is an eating disorder characterized by extreme hypophagia, hyperactivity, and fear of weight gain. No approved pharmacological treatments exist for AN despite high mortality rates. The activity-based anorexia (ABA) phenomenon models aspects of AN in rodents, including progressive weight loss, reduced food intake, and hyperactivity. First, we optimized the ABA paradigm for mice. We compared mouse strains (Balb/cJ, A/J) for susceptibility with ABA, and evaluated the effects of different ...
Tópico(s): Obsessive-Compulsive Spectrum Disorders
2012 - Springer Nature | Neuropsychopharmacology
Giles Smith, Andrew Robson, Gráinne Gilmore, Shaun Thorpe (Editor), Janice Turner, Aminatta Forna, Kitty Balint-Kurti, Robert Hands, Thair Shaikh, Robert Cole, Andrew Pierce, CAH, Simon Bucknall, Dr Thomas Stuttaford and Suzi Godson, Neera Sharma (Principal policy officer), Sally Shalam, Simon Barnes, Robert Thicknesse, Jessica Mann, Paul Hoggart, Adam Luck, Mark Souster, Mark Frary, Edward Owen and Daniel McGrory, Jane Knight, Clare Lazaro, Michael Evans Defence Editor, Dr Toby Murcott, Adam Sherwin and Nic Hopkins, Philip Howard, Richard Beard, Hannah Betts, Melanie Rickey, Tara Holmes, James Ducker, Rachel Campbell-Johnston, Nic Hopkins, Robert Spence, Kate Reardon, Chris Bowers, Elizabeth Judge, Richard Irving, Richard Owen and Catherine Philp, Carl Mortished, Simon Schama, Wendy Ide, Jeremy Whittle, Kevin Eason, Philippe Naughton, Clare Stewart, Giles Coren, Robert Yates, David Sharrock, Vivienne Parry, Antonia Senior, Kevin MacDonald, Hilary Rose, Valerie Elliott, Derek Whitehead, Katherine Swift, Gabby Logan, Anthony Gardner, Mike Pflanz, Dominic Walsh, Ronald Tiersky, James Doran Wall Street Correspondent, Alan Webster, Rob Penn, Kevin James, Sarah Bakewell, Allan Simmons, Joe Morgan, Jill Dupleix, Tim Reid, Daniel Finkelstein, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Jane Clarke, Renecca O'connor, Jo Morris, Nick Robinson, Alan Hamilton, Richard Beeston Diplomatic Editor and Nick Blanford, Gerald Mortimer, David Michael, Alan McMurray, Charles Bremner, Richard Johnson, Heather McGregor, Stefanie Marsh, Matt Dickinson Chief Football Correspondent, Liz Chong, Greg Hurst, Peter Barnard, David Charter, Tim Teeman, Alan Alexander, Matthew Pinsent, michael schumacher, Derwent May, Angela Jameson, Sue Hopkins, Russell Kempson, Peter Paphides, Paula Hawkins, James Cagney, Jerome Burne, Oliver Kay, Gerard Baker, Stephen Anderton, Lisa Grainger, Stevie Chick, Mark Atherton, Lisa Armstrong, John Westerby, Jane Wheatley, Sam Coates, Chris Power, Andrew Miller, Simon de Bruxelles, Rob Wright, Magnus Grimond, Stuart Miles, Benjamin Fry, David Powell Athletics Correspondent, Raymond Keene, Irma Kurtz, Suzi Godson, Lewis Smith, Matthew Pryor, Tim Richardson, Rebecca O'Connor, Lesley Regan, Angela Jameson and Dominic Walsh, Christine Buckley Industrial Editor, Robert Galster, Kaveh Solhekol, Kate Green Chief Executive, Ben Harries, Jeremy Page, Darvin Leader, Clifford Coonan, Andrew G. Marshall, Chris Campling, Patrick Hosking, Helen Nugent, Mark Irving, Rebecca O'connor, Roger Boyes, Catharine Morris, Joseph Silver, Peter Dixon, Gabriel Rozenberg Economics Reporter, Gillian Harris Scotland correspondent, Nick Hasell, Ted C. Fishman, Chloë Bryan-Brown, Jonathan Self, David Hands Rugby Correspondent, Edward Hagan, Paul Simons, Chris Condron, Maureen Shaw, Nick Szczepanik, Nell Harman Tennis Correspondent, Dominic Kennedy, Joanna Pitman, Brian Case, Philip Webster Political Editor, Robert Crampton, Suzanne Schlosberg, Julian Sharpe, Geri Halliwell, Rufus Wainwright, Matthew Parris, Jennai Cox, Keiran Proffer, Jonathan Rendall, George Barker, Tim Wapshott, Alan Lee, Michael W. Sim, Iain Finlayson, Carollne Merrell Banking Correspondent, Ben MacIntyre, Helen Pridham, Martin Cruz Smith, Theodore Dairymple, Richard Beeston, Alison Gibson, David Bolchover, Graham Searjeant, John Naish, David Charter and Adam Luck, Anne Ashworth Personal Finance Editor, Annabelle Thorpe, Martin Waller, Howard Jacobson, Gary Duncan and Gabriel Rozenberg, Chris Ayres, Colin Cowell, Richard Dowden Executive Director, Carl Mortished International Business Editor, Fiona MacTaggart, Benedict Nightingale, Anna Shepard, Angus Batey, Jonathan Meades, Froeda Jigjes, Stephen Dalton, Jill Crawshaw, Leo Lewis, Richard Morrison, Alyson Rudd, Tom Chesshyre, Fred Dellar, Simon Crompton, Richard Long (Director), Owen Slot, Dan Sabbagh and Sam Coates, Cath Urquhart Travel Editor, Jenny Davey, David Robertson, Cynthia Ozick, Jonathan Harvey, Angus MacIeod, Tom Baldwin and David Charter, Sam Lister Health Correspondent, Patience Wheatcroft, Janine di Giovanni, Christopher Irvine, Sophie Kirkham, Simon Freeman and Tony Halpin, Sandra Martin,
... Robert Crumb, the cartoonist, appears on The Culture … Jamie proposes to Claire in tonight's episode of ...
2005 - Gale Group | TDA
Leslie R. Amodeo, Matthew S. McMurray, Jamie D. Roitman,
In a continuously changing environment, in which behavioral outcomes are rarely certain, animals must be able to learn to integrate feedback from their choices over time and adapt to changing reward contingencies to maintain flexible behavior. The orbitofrontal region of prefrontal cortex (OFC) has been widely implicated as playing a role in the ability to flexibly control behavior. We used a probabilistic reversal learning task to measure rats' behavioral flexibility and its neural basis in the ...
Tópico(s): Stress Responses and Cortisol
2016 - Elsevier BV | Neuroscience
Charles Owen, Srikumar Sen, Boxing Correspondent, Phil Yates, Victoria McKee, Jon Ashworth, Frank Samson, James Lunt, Alexandra Frean, Richard Ford, Home Correspondent, Tim Judah, F. J. Gillo, Michael Basingstoke, David McMurray (Chairman), Ivo Tennant, Ross Tieman, Industrial Correspondent, Karl Knight, Philip Howard, Richard Hoggart, Hilary Finch, Ian Murray, Nicholas Wood and Anatole Kaletsky, Michael Binyon, Henry Kelly, Carol Leonard, Lynne Truss, Geoffrey Howe, John Best, Jay Andrews, Stewart Tendler, Crime Correspondent, Geoff Brown, Katy Bravery, Joe Joseph, Bruce Clark, Nicholas Wood Political Correspondent, Peter Ball, Graham Jones (Headmaster), Martin Fletcher and Jamie Dettmer, Rachel Kelly, Libby Purves, Douglas Broom, Nick Nuttall Technology Correspondent, Alan Hamilton, A. J. Smith, Nicholas Watt, Louise Hidalgo, Michael Clark, Anatole Kaletsky, Michael Hamlyn, John Warwick Montgomery, Neil Bennett Banking Correspondent, John Percival, Peter Barnard, D. J. Dawson, Elizabeth Obadina, Tara King (Senior Prefect), David Johnson, Michael McCarthy Environment Correspondent, George Brock, Sydney Friskin, Melinda Wittstock Media Correspondent, David Miller, Geoffrey Wheeler, Matthew D'ancona, Education Reporter, Alison Roberts, John Higgins, David Powell Athletics Correspondent, Kerry Gill, John Dervaird, Raymond Keene, Chess Correspondent, Paul Wilkinson, Mark T. Elvins, Liz Gill, James Flecker (Headmaster), Roger Boyes, Roseland McCarthy (Headmistress), Ian Ross, Bryan Appleyard, Brian Beel, Richard Cross, Rodney Hobson, David Hands Rugby Correspondent, Nicholas Wood, Harvey Elliott, Travel Correspondent, John Goodbody, Clive White, Richard Evans Racing Correspondent, Sheila Gunn Political Correspondent, John Shaw, Alan Lee Cricket Correspondent, Michael Phillips, Nadine Meisner, Stephen Pettitt, William Cash, Martin Waller, Chalfont, Chairman, Alan Coren, Anthea Gerrie, Benedict Nightingale, Frances Gibb Legal Correspondent, Lulu Yu, Jack Bailey, Lindsay Cook and Colin Narbrough, Anne McElvoy, Andrew Davidson, Andrew Finkel, John Phillips, W. Lunel, Headmistress, Adam Kelliher, St John of Fawsley, Matthew Bond, Ross Tieman, Colin Campbell, John O'leary, Education Correspondent, Peter Robinson, Philip Jacobson, Andrew Longmore, Tennis Correspondent, Stuart Jones, Football Correspondent,
More rate cuts on the way, Major believes Sterling sidesteps the mark England plays host M62 appeal Rouble floats GP on trial O&Y strategy Index Life & ...
1992 - Gale Group | TDA
Bob McMurray, Jamie Klein‐Packard, J. Bruce Tomblin,
Eight to 11% of children have a clinical disorder in oral language (Developmental Language Disorder, DLD). Language deficits in DLD can affect all levels of language and persist through adulthood. Word-level processing may be critical as words link phonology, orthography, syntax and semantics. Thus, a lexical deficit could cascade throughout language. Cognitively, word recognition is a competition process: as the input (e.g., lizard) unfolds, multiple candidates (liver, wizard) compete for recognition. ...
Tópico(s): Neurobiology of Language and Bilingualism
2019 - Elsevier BV | Cognition
Leslie R. Amodeo, Eliza Jacobs-Brichford, Matthew S. McMurray, Jamie D. Roitman,
Though commonly used as a treatment for ADHD, the psychostimulant methylphenidate (MPH) is also misused and abused in adolescence in both clinical and general populations. Although MPH acts via pathways activated by other drugs of abuse, the short- and long-term effects of MPH on reward processing in learning and decision-making are not clearly understood. We examined the effect of adolescent MPH treatment on a battery of reward-directed behaviors both in adolescence during its administration and ...
Tópico(s): Treatment of Major Depression
2017 - Elsevier BV | Behavioural Brain Research
Matthew S. McMurray, Leslie R. Amodeo, Jamie D. Roitman,
Alcohol use is common in adolescence, with a large portion of intake occurring during episodes of binging. This pattern of alcohol consumption coincides with a critical period for neurocognitive development and may impact decision-making and reward processing. Prior studies have demonstrated alterations in adult decision-making following adolescent usage, but it remains to be seen if these alterations exist in adolescence, or are latent until adulthood. Here, using a translational model of voluntary ...
Tópico(s): Neuroendocrine regulation and behavior
2014 - Public Library of Science | PLoS ONE
Matthew S. McMurray, Leslie R. Amodeo, Jamie D. Roitman,
Critical development of the prefrontal cortex occurs during adolescence, a period of increased independence marked by decision making that often includes engagement in risky behaviors, such as substance use. Consumption of alcohol during adolescence has been associated with increased impulsivity that persists across the lifespan, an effect which may be caused by long-term disruptions in cortical processing of rewards. To determine if alcohol consumption alters cortical encoding of rewards of different ...
Tópico(s): Memory and Neural Mechanisms
2015 - Springer Nature | Neuropsychopharmacology
Banu Aygün, Lisa Wruck, William H. Schultz, Brigitta U. Mueller, R. Clark Brown, Lori Luchtman‐Jones, Sherron M. Jackson, Rathi V. Iyer, Zora R. Rogers, Sharada A. Sarnaik, Alexis A. Thompson, Cynthia Gauger, Ronald W. Helms, Russell E. Ware, Brigitta U. Mueller, Bogdan Dinu, Kusum Viswanathan, Natalie Sommerville-Brooks, Betsy Record, Matthew M. Heeney, Meredith Anderson, Janet L. Kwiatkowski, J. R. Olson, M.C. Brown, Lakshmanan Krishnamurti, R. W. McCollum, Kamar Godder, Jennifer Newlin, William Owen, Stephen C. Nelson, Katie Bianchi, Sheronda Brown, Margaret Lee, Courtney D. Thornburg, Charles Daeschner, Cynthia Brown, Lisa Kuisel, Ramamoorthy Nagasubramanian, Brian Berman, Mary DeBarr, Sharon Singh, Antonella Farrell, Eileen Hansbury, Scott Miller, Kathy Rey, Isaac Odame, Nagina Parmar, Manuella Merelles-Pulcinni, Leah Adix, Lee Hilliard, Jeanine Dumas, Michelle Neier, Stephanie Ferreira de Farias, Alvarez Ofelia Alvarez, Williams Patrice Williams, Mary T. Walker, Hamayun Imran, Stephanie Durggin, Elizabeth Yang, Mary Murphy,
... Systems Division, Inc. (Nancy Yovetich PhD, Christopher Woods, Jamie Spencer, Marsha McMurray) for their valuable contributions to the study. TWiTCH ...
Tópico(s): Iron Metabolism and Disorders
2011 - Wiley | American Journal of Hematology
Oonagh Harness, Kimberly Jamie, Robert G. McMurray,
The role of time in organisational and relational development remains an understudied component of work and employment. In response, this article draws attention to the ways that temporality informs relations between workers and clients in service work. Drawing on data from interviews and observations with hair stylists in salons located in the North East of England from 2016 to 2018, we provide a nuanced account of emotional service work by considering the role of the temporal dynamics of recurrence ...
Tópico(s): Work-Family Balance Challenges
2020 - SAGE Publishing | Work Employment and Society
S. G. McIlroy, E. A. Goodall, Jamie Rainey, C.H. McMurray,
Tópico(s): Meat and Animal Product Quality
1988 - Elsevier BV | Agricultural Systems
Keith S. Apfelbaum, Jamie Klein‐Packard, Bob McMurray,
A common critique of the Visual World Paradigm (VWP) in psycholinguistic studies is that what is designed as a measure of language processes is meaningfully altered by the visual context of the task. This is crucial, particularly in studies of spoken word recognition, where the displayed images are usually seen as just a part of the measure and are not of fundamental interest. Many variants of the VWP allow participants to sample the visual scene before a trial begins. However, this could bias their ...
Tópico(s): Reading and Literacy Development
2021 - Elsevier BV | Journal of Memory and Language
Christopher A. Jolly, Jamie C. Laurenz, David N. McMurray, Robert S. Chapkin,
T cell activation results in the generation of diacylglycerol (DAG), the physiological activator of protein kinase C. Recently, ceramide, a bioactive lipid intracellular second messenger, has been shown to play a positive role in T cell proliferation. Most studies examining mitogen induction of DAG and ceramide in T cells have been conducted in cell lines over short periods of time (0-30 min) relative to the 2-3-h time frame required for commitment to proliferation. Therefore, we examined T cell mitogen- ...
Tópico(s): T-cell and B-cell Immunology
1996 - Elsevier BV | Immunology Letters
Jamie Giffuni, Robert G. McMurray, Todd A. Schwartz, Diane Berry,
Weight, body fatness and ambulatory pattern all have the potential to affect accelerometer output and cause differences in output between overweight and normal-weight adults. The purpose of this study was to determine if Actical (Philips Respironics, Bend, OR) activity count cut-points for moderate and vigorous intensity exercise are different for overweight adults compared to normal-weight adults. Overweight adults with BMI >25 kg/m² (n=29) and Normal-Weight adults (n=25) walked at 3.2 and 4.8 km∙h- ...
Tópico(s): Children's Physical and Motor Development
2012 - Berkeley Electronic Press | International journal of exercise science
Marcus E. Galle, Jamie Klein‐Packard, Kayleen Schreiber, Bob McMurray,
Abstract Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme ...
Tópico(s): Neuroscience and Music Perception
2019 - Wiley | Cognitive Science
Matthew S. McMurray, Sineadh M. Conway, Jamie D. Roitman,
Animal models of decision-making rely on an animal's motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2017 - Society for Neuroscience | eNeuro
Susan L. Kraft, Deanna D. Dailey, Matthew Kovach, Karen Stasiak, Jamie Bennett, Christine T. McFarland, David N. McMurray, Angelo Izzo, Ian M. Orme, Randall J. Basaraba,
ABSTRACT We utilized magnetic resonance imaging to visualize lesions in the lungs of guinea pigs infected by low-dose aerosol exposure to Mycobacterium tuberculosis . Lesions were prominent in such images, and colorized three-dimensional reconstructions of images revealed a very uniform distribution in the lungs. Lesion numbers after 1 month were approximately similar to the aerosol exposure algorithm, suggesting that each was established by a single bacterium. Numbers of lesions in unprotected and ...
Tópico(s): Diagnosis and treatment of tuberculosis
2004 - American Society for Microbiology | Infection and Immunity
Jack L. McMurray, Anouk von Borstel, Taher E. Taher, Eleni Syrimi, Graham S. Taylor, Maria Sharif, Jamie Rossjohn, Ester B. M. Remmerswaal, Fréderike J. Bemelman, Felipe A. Vieira Braga, Xi Chen, Sarah A. Teichmann, Fiyaz Mohammed, Andrea A. Berry, Kirsten E. Lyke, Kim C. Williamson, Michael J. T. Stubbington, Martin S. Davey, Carrie R. Willcox, Benjamin E. Willcox,
γδ T cells are generally considered innate-like lymphocytes, however, an "adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation of adaptive γδ T cell immunobiology, we combined single-cell transcriptomics, T cell receptor (TCR)-clonotype assignment, ATAC-seq, and immunophenotyping. We show that adult Vδ1+ T cells segregate into TCF7+LEF1+Granzyme Bneg (Tnaive) or T-bet+Eomes+BLIMP-1+Granzyme B+ (Teffector) transcriptional subtypes, with clonotypically expanded TCRs ...
Tópico(s): Single-cell and spatial transcriptomics
2022 - Cell Press | Cell Reports
Hiddo J.L. Heerspink, David Z.I. Cherney, Douwe Postmus, Bergur V. Stefánsson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John J.V. McMurray, Ricardo Correa‐Rotter, Peter Rossing, C. David Sjöström, Robert D. Toto, David C. Wheeler, Hiddo J.L. Heerspink, David C. Wheeler, Glenn M. Chertow, Ricardo Correa‐Rotter, Tom Greene, Fan Fan Hou, John J.V. McMurray, Peter Rossing, Robert D. Toto, Bergur V. Stefánsson, Anna Maria Langkilde, Laura Maffei, Pablo Raffaele, S. Solís, César A. Arias, Dov Aizenberg, Carolina Lúquez, Cesar Javier Zaidman, Natalia Cluigt, M. Mayer, Andres Alvarisqueta, A. Wassermann, Rafaël Maldonado, J. Bittar, M. Maurich, L.E. Gaite, Néstor H. García, Louise E. Sivak, Pablo Ramallo, Juan Carlos Santos, Ruben Garcia Duran, Juan Oddino, A Marañón, Lília Nigro Maia, Dánae Duana Ávila, Elvino Barros, Maria H Vidotti, Daniel Panarotto, Irene de Lourdes Noronha, Luiz Alberto Andreotti Turatti, Luciane Mônica Deboni, María Eugênia Fernandes Canziani, Miguel C. Riella, Marcelo Rodrigues Bacci, Raphael Paschoalin, R. J. Franco, João Carlos Goldani, Eric St-Amour, Andrew Steele, R. Goldenberg, Sanjay Pandeya, Harpreet S. Bajaj, David Z.I. Cherney, Stéphanie Kaiser, James Conway, Sharron Chow, G. Howard Bailey, Jean‐Philippe Lafrance, Jonathan Winterstein, S. Cournoyer, D. Gaudet, F. Madore, Robyn L. Houlden, Aaron Dowell, Michel R. Langlois, Nicola Muirhead, Hasnain Khandwala, Adeera Levin, Fan Fan Hou, Ying Xue, Lingyan Zuo, Chuan‐Ming Hao, Zhaohui Ni, Xing Changying, N. Chen, Yugang Dong, Rong Zhou, Xiao Xu, Yiping Zou, Chu Wang, Liu B, Qian Chen, Miao Lin, Qing Luo, D. Zhang, Jann‐Yuan Wang, Mingyi Chen, Xinyue Wang, Anyuan Zhong, Junguo Dong, Chan Zhu, Tiekun Yan, Ping Luo, Yan Ren, Pearl Pai, David K.B. Li, Rui Zhang, Jun Zhang, Mangmang Xu, Yong Zhuang, Yaozhong Kong, Xin Yao, Xiaomei Peng, Frederik Persson, Troels Krarup Hansen, Rikke Borg, Ulrik Pedersen‐Bjergaard, Daniel J. Hansen, M. Hornum, Hermann Haller, Gerhard Klausmann, Diethelm Tschöpe, Thilo Krüger, Peter L. Gross, Christian Hugo, Nicholas Obermüller, Ludger Rose, Patrick Mertens, Helga Zeller-Stefan, Andreas Fritsche, Lutz Renders, Jürgen Müller, Klemens Budde, Bernd Schröppel, István Wittmann, Péter Vörös, Marek Dudáš, Ádám G. Tabák, Róbert Kirschner, Annamária Letoha, I. Balku, Zs. Hermányi, Gábor Zakar, I. Mezei, Gergely Nagy, J Lippai, Andrea H. Németh, Dinesh Khullar, Prakash Kikkeri Gowdaiah, Edwin Fernando Mervin, V. Rao, D. Dewan, K.R. Goplani, Vatsalya Maddi, Milind Vyawahare, Rakesh Pulichikkat, Rajendra Pandey, Sharad Kumar Sonkar, Vineet Gupta, Samagra Agarwal, Ananthi J. Asirvatham, Anita Ignatius, Sanjay Chaubey, Sreelatha Melemadathil, H. Alva, Y. Kadam, Hiroaki Shimizu, Atsushi Sueyoshi, Hiroaki Takeoka, Abe Y, Takumi Imai, Yukiko Onishi, Yasuko Fujita, Yukichi Tokita, Mitsuaki Oura, Y Makita, Akira Idogaki, Ryo Koyama, H Kikuchi, Naoki Kashihara, Toshimasa Hayashi, Yukio Ando, Tsuyoshi Tanaka, Motohiro Shimizu, Sumi Hidaka, Tomohito Gohda, Kouichi Tamura, Masami Abe, Yoshito Kamijo, Toshiyuki Imasawa, Yasunori Takahashi, Mikihiro Nakayama, Masayoshi Tomita, F. Hirano, Mikihiro Nakayama, Yasushi Fukushima, Arihiro Kiyosue, Soichi Kurioka, E. Imai, Kazuo Kitagawa, Masako Waki, Jun Wada, K. Uehara, Hirotsugu Iwatani, Keiko Ota, Satomi Shibazaki, Kouichi Tamura, Kan Katayama, Ichiei Narita, Masahiro Iinuma, Satoko Matsueda, Shoji Sasaki, Akio Yokochi, Tatsuo Tsukamoto, Teizo Yoshimura, Shin‐Wook Kang, Sangmi Lee, Chun Sen Lim, Hee Seung Chin, Kwon Wook Joo, Seungyeup Han, Tara I. Chang, Sangshin Park, Hae‐Sim Park, C.W. Park, Byoung Geun Han, Dongchul Cha, Sung-Sik Yoon, Woo Joo Kim, Sang Wun Kim, Dong‐Ryeol Ryu, Ricardo Correa‐Rotter, Sergio Saul Irizar Santana, G. Hernandez Llamas, Rafael Valdez-Ortiz, N. Nicolas, Guillermo González-Gálvez, José Roberto Lazcano Soto, T. Bochicchio Riccardelli, E Llamas, Denisse Ramos Ibarra, Maira Gabrielle Silva Melo, José Gerardo González‐González, Jose Hector Sanchez Mijangos, Margarida Robalo, Armando García Castillo, Hélard Manrique, J. Farfan, Ramón Vargas, A. Valdivia, A. Dextre, Encarnación Moral Escudero, Jorge R Calderon Ticona, Louis Gonzales, Jaime Guerrero Villena, Luís León, G. Molina, Alene Saavedra, Emanuel Pimenta Garrido, Hugo Arbañil, Sofia Marquez, J. Rodriguez, Rey Isidto, A.J. Villaflor, M.A. Gumba, Louie Tirador, Rhea Severina Comia, Rosa Allyn Sy, Mitchell Guanzon, Grace Aquitania, Norman Cornelio De Asis, Andréa Silva, Carlos Romero, Maggie Lim, Romina Danguilan, Michał Nowicki, H Rudzki, Karenia Landa, Izabela Kucharczyk-Bauman, B. Gogola-Migdal, M. Golski, Anna Olech-Cudzik, Tomasz Stompór, T. Szczepanik, Beata Mikłaszewicz, R Ściborski, Marek Kuźniewski, Kazimierz Ciechanowski, Danuta Wrońska, Wiesław Klatko, Stanisław Mazur,
This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high-risk patients based on having chronic kidney disease (CKD) and substantial albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial that had a median follow-up of 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200–5000 mg/g and estimated glomerular filtration rate 25–75 mL/min/1.73m2) were randomized to dapagliflozin ...
Elsevier BV
Produção Nacional
Revisado por pares
David C. Wheeler, Bergur V. Stefánsson, М. М. Батюшин, О. V. Bilchenko, David Z.I. Cherney, Glenn M. Chertow, Walter Douthat, Jamie P. Dwyer, Elizabeth Escudero, Roberto Pecoits–Filho, Hans Furuland, José Luis Górriz, Tom Greene, Hermann Haller, Fan Fan Hou, Shin‐Wook Kang, Rey Isidto, Dinesh Khullar, Patrick B. Mark, John J.V. McMurray, Naoki Kashihara, Michał Nowicki, Frederik Persson, Ricardo Correa‐Rotter, Peter Rossing, Robert D. Toto, Kausik Umanath, Pham Van Bui, István Wittmann, Magnus Lindberg, C. David Sjöström, Anna Maria Langkilde, Hiddo J.L. Heerspink,
The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD; NCT03036150) trial was designed to assess the effect of the sodium-glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on kidney and cardiovascular events in participants with CKD with and without type 2 diabetes (T2D). This analysis reports the baseline characteristics of those recruited, comparing them with those enrolled in other trials.In DAPA-CKD, 4304 participants with a urinary albumin:creatinine ratio ( ...
Tópico(s): Pancreatic function and diabetes
2020 - Oxford University Press | Nephrology Dialysis Transplantation
Joel Martin, Cliff Han, Laurie Gordon, Astrid Terry, Shyam Prabhakar, Xinwei She, Gary Xie, Uffe Hellsten, Yee Man Chan, Michael R. Altherr, Olivier Couronne, Andrea Aerts, Eva Bajorek, Stacey Black, Heather Blumer, Elbert Branscomb, Nancy C. Brown, William Bruno, Judith M. Buckingham, David F. Callen, Connie S. Campbell, Mary L. Campbell, E.W. Campbell, Chenier Caoile, Jean F. Challacombe, Leslie Chasteen, Olga Chertkov, Han Chu, Mari Christensen, Lynn M. Clark, Judith D. Cohn, Mirian Denys, John C. Detter, Mark Dickson, Mira Dimitrijevic-Bussod, Julio Escobar, Joseph J. Fawcett, Dave Flowers, Dea Fotopulos, Tijana Glavina, María Lucía Gutiérrez Gómez, Eidelyn Gonzales, David Goodstein, Lynne Goodwin, Deborah L. Grady, Igor V. Grigoriev, Matthew Groza, Nancy Hammon, Trevor Hawkins, Lauren E. Haydu, C.E. Hildebrand, Wayne Huang, Sanjay Israni, Jamie Jett, Phillip B. Jewett, Kristen Kadner, Heather Kimball, Arthur Kobayashi, Marie-Claude Krawczyk, Tina Leyba, Jonathan L. Longmire, Frederick Lopez, Yunian Lou, Steve Lowry, Thom Ludeman, Chitra Manohar, Graham A. Mark, Kimberly L. Mcmurray, Linda Meincke, Jenna Morgan, Robert K. Moyzis, Mark Mundt, A. Christine Munk, Richard D. Nandkeshwar, Sam Pitluck, Martin Pollard, Paul Predki, B. Parson-Quintana, Lucı́a Ramı́rez, Sam Rash, James Retterer, Darrell Ricke, Donna L. Robinson, Álex Rodríguez, Asaf Salamov, Elizabeth Saunders, Duncan Scott, Timothy Shough, Raymond L. Stallings, Malinda Stalvey, Robert Sutherland, Roxanne Tapia, Judith G. Tesmer, Nina Thayer, Linda S. Thompson, Hope Tice, David C. Torney, Mary Bao Tran-Gyamfi, Ming Jer Tsai, Levy Ulanovsky, Anna Ustaszewska, Nu Vo, Paul S. White, Albert L. Williams, Patricia L. Wills, Jung-Rung Wu, Kevin Wu, Joan Yang, Pieter DeJong, David Bruce, Norman A. Doggett, Larry L. Deaven, Jeremy Schmutz, Jane Grimwood, Paul Richardson, Daniel S. Rokhsar, Evan E. Eichler, Paul Gilna, Susan Lucas, R Myers, Edward M. Rubin, L Pennacchio,
Human chromosome 16 features one of the highest levels of segmentally duplicated sequence among the human autosomes. We report here the 78,884,754 base pairs of finished chromosome 16 sequence, representing over 99.9% of its euchromatin. Manual annotation revealed 880 protein-coding genes confirmed by 1,670 aligned transcripts, 19 transfer RNA genes, 341 pseudogenes and three RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for ...
Tópico(s): Nuclear Structure and Function
2004 - Nature Portfolio | Nature
... Field Denise Filios Ian Forrest Allen James Fromherz Jamie Fumo Blanca Garí Kantik Ghosh Gail McMurray Gibson Shannon Godlove Eric Goldberg Piotr Górecki Lindy ...
Tópico(s): Medieval Literature and History
2023 - University of Chicago Press | Speculum
Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen, Richard Goater, Frank Schwach, Ian Harrison, Joel Hellewell, Cristina V. Ariani, Sónia Gonçalves, David K. Jackson, Ian Johnston, Alexander W. Jung, Callum Saint, John Sillitoe, Maria Suciu, Nick Goldman, Jasmina Panovska‐Griffiths, Irina Abnizova, Louise Aigrain, Alex Alderton, Mozam Ali, Laura Allen, Roberto Amato, Ralph Anderson, Cristina V. Ariani, Siobhan Austin-Guest, Sendu Bala, Jeffrey C. Barrett, Andrew R. Bassett, Kristina Battleday, James R. Beal, Mathew A. Beale, Charlotte Beaver, Sam Bellany, Tristram Bellerby, Katie Bellis, Duncan Berger, Matthew Berriman, Emma Betteridge, Paul Bevan, Simon Binley, Jason Bishop, Kirsty Blackburn, James Bonfield, Nick Boughton, Sam Bowker, Timothy Brendler-Spaeth, Iraad F. Bronner, Tanya Brooklyn, Sarah K. Buddenborg, R.L. Bush, Catarina Caetano, Alex Cagan, Nicola Carter, Joanna Cartwright, Tiago Monteiro, Liz Chapman, Tracey-Jane Chillingworth, Peter Clapham, Richard Clark, Adrian Clarke, Catriona Clarke, Daryl Cole, Elizabeth Cook, Maria Coppola, Linda Cornell, Clare Cornwell, Craig Corton, Abby Crackett, Alison Cranage, Harriet Craven, Sarah Craw, Mark Crawford, Tim Cutts, Monika Dabrowska, Matt Davies, Robert M. Davies, Joseph Dawson, Callum Day, Aiden Densem, Thomas Dibling, Cat Dockree, D. C. Dodd, Sunil Kumar Dogga, Matthew J. Dorman, Gordon Dougan, Martin Dougherty, Alexander Dove, Lucy Drummond, Eleanor Drury, Monika Dudek, Jillian Durham, Laura Durrant, Elizabeth Easthope, Sabine Eckert, Peter Ellis, Ben W. Farr, Michael Fenton, Marcella Ferrero, Neil Flack, Howerd Fordham, Grace Forsythe, Luke Foulser, Matt Francis, Audrey Fraser, Adam Freeman, Anastasia Galvin, Maria Garcia-Casado, Alex Gedny, Sophia T. Girgis, James Glover, Sónia Gonçalves, Scott Goodwin, Oliver Gould, Marina Gourtovaia, Andy Gray, Emma Gray, Chris Griffiths, Yong Gu, Florence Guerin, Will Hamilton, Hannah Hanks, Ewan M. Harrison, Alexandria Harrott, Edward Harry, Julia Harvison, Paul T. Heath, Anastasia Hernández-Koutoucheva, Rhiannon Hobbs, Dave Holland, Sarah Holmes, Gary Hornett, Nicholas Hough, Liz Huckle, Lena Hughes-Hallet, Adam Hunter, Stephen Inglis, Sameena Iqbal, Adam Jackson, David K. Jackson, Keith James, Dorota Jamrozy, Carlos Jimenez Verdejo, Matthew Jones, Kalyan Kallepally, Leanne Kane, Keely Kay, Sally Kay, Jon Keatley, Alan Keith, Alison King, Lucy Kitchin, Matt Kleanthous, Martina Klimekova, Petra Korlević, Ksenia Krasheninnkova, Greg Lane, Cordelia Langford, Adam Laverack, Katharine Law, Mara Lawniczak, Stefanie V. Lensing, Steven N. Leonard, Laura Letchford, Kevin Lewis, Amanah Lewis-Wade, Jennifer Liddle, Quan Lin, Sarah Lindsay, Sally Linsdell, Rich Livett, Stephanie W. Lo, Rhona Long, Jamie Lovell, Jon Lovell, Catherine Ludden, James Mack, Mark Maddison, Aleksei Makunin, Irfan Mamun, Jenny Mansfield, Neil Marriott, Matt Martin, Matthew Mayho, Shane McCarthy, Jo McClintock, Samantha McGuigan, Sandra McHugh, Liz McMinn, Carl Meadows, Emily Mobley, Robin J. Moll, Maria Morra, Leanne Morrow, Kathryn Murie, Sian Nash, Claire Nathwani, Plamena Naydenova, Alexandra Neaverson, Andrew Nelson, Ed Nerou, Jon Nicholson, Tabea Nimz, Guillaume Noell, Sarah O’Meara, Valeriu Ohan, Karen Oliver, Charles Olney, Doug Ormond, Ágnes Oszlánczi, Steve Palmer, Yoke Fei Pang, Barbora Pardubska, Naomi Park, Aaron Parmar, Gaurang Patel, Minal Patel, Maggie Payne, Sharon J. Peacock, Arabella Petersen, Deborah Plowman, Tom Preston, Liam Prestwood, Christoph Puethe, Michael A. Quail, Diana Rajan, Shavanthi Rajatileka, Richard Rance, Suzannah Rawlings, Nicholas Redshaw, Joe Reynolds, Mark Reynolds, Simon Rice, Matt Richardson, Connor Roberts, Katrina Robinson, Melanie Robinson, David M. Robinson, Hazel Rogers, Eduardo Martin Rojo, Daljit Roopra, Mark E. Rose, Luke Rudd, Ramin Sadri, Nicholas Salmon, David Saul, Frank Schwach, Clare L. Scott, Phil Seekings, Lesley Shirley, Alison Simms, Matthew Sinnott, Shanthi Sivadasan, Bart Siwek, Dale Sizer, Kenneth Skeldon, Jason Skelton, Joanna Slater-Tunstill, Lisa Sloper, Nathalie Smerdon, Chris Smith, Christen Smith, James Smith, Katie Smith, Michelle Smith, Sean B. Smith, Tina Smith, Leighton Sneade, C. Soria, Catarina Sousa, Emily Souster, Andrew Sparkes, Michael Spencer-Chapman, Janet Squares, Robert Stanley, Claire Steed, Tim Stickland, Ian Still, Michael R. Stratton, Michelle Strickland, Allen Swann, Agnieszka Świątkowska, Neil Sycamore, Emma Swift, Edward Symons, Suzanne Szluha, Emma Taluy, Nunu Tao, Katy Taylor, Sam Taylor, Stacey Thompson, Mark A. Thompson, M. Thomson, Nicholas M. Thomson,
Abstract The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump ...
Nature Portfolio
Carol R. Horowitz, Anthony L. Suchman, William T. Branch, Richard M. Frankel,
... 1979;241:1483-6. [PMID: 430687] CrossrefMedlineGoogle Scholar7. McMurray JE, Williams E, Schwartz MD, Douglas J, Van ... PMID: 8271093] CrossrefMedlineGoogle Scholar11. Wetterneck TB, Linzer M, McMurray JE, Douglas J, Schwartz MD, Bigby J, et ... 1998;73:360-2. [PMID: 9580711] CrossrefMedlineGoogle Scholar26. McMurray JE, Schwartz MD, Genero NP, Linzer M. The ... Rhodes for her insights and Dale Matthews and Jamie Kerr for their contributions.Grant Support: At the ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2003 - American College of Physicians | Annals of Internal Medicine
Oliver Eales, Andrew J. Page, Leonardo de Oliveira Martins, Haowei Wang, Barbara Bodinier, David Haw, Jakob Jonnerby, Christina Atchison, Samuel C. Robson, Thomas R. Connor, Nicholas J. Loman, Tanya Golubchik, Rocio T. Martinez Nunez, David Bonsall, Andrew Rambaut, Luke B. Snell, Rich Livett, Catherine Ludden, Sally Corden, Eleni Nastouli, Gaia Nebbia, Ian Johnston, Katrina Lythgoe, M. Estée Török, Ian Goodfellow, Jacqui Prieto, Kordo Saeed, David K. Jackson, Catherine Houlihan, Dan Frampton, William L. Hamilton, Adam A. Witney, Giselda Bucca, Cassie F. Pope, Catherine Moore, Emma C. Thomson, Ewan M. Harrison, Colin P. Smith, Fiona Rogan, Shaun M. Beckwith, Abigail Murray, Dawn Singleton, Kirstine Eastick, Liz A. Sheridan, Paul Randell, Leigh Jackson, Cristina V. Ariani, Sónia Gonçalves, Derek Fairley, Matthew Loose, Joanne Watkins, Samuel Moses, Sam Nicholls, Matthew Bull, Roberto Amato, Darren Smith, David M. Aanensen, Jeffrey C. Barrett, Dinesh Aggarwal, James G. Shepherd, Martin D. Curran, Surendra Parmar, Matthew O. Parker, Catryn Williams, Sharon Glaysher, Anthony P. Underwood, Matthew Bashton, Nicole Pacchiarini, Katie F. Loveson, Matthew Byott, Alessandro M. Carabelli, Kate Templeton, Thushan I. de Silva, Dennis Wang, Cordelia F. Langford, John Sillitoe, Rory Gunson, Simon Cottrell, Justin O’Grady, Dominic Kwiatkowski, Patrick Lillie, Nicholas Cortes, Nathan Moore, Claire Thomas, Phillipa Burns, Tabitha Mahungu, Steven Liggett, Angela H. Beckett, Matthew T. G. Holden, Lisa J. Levett, Husam Osman, Mohammed O. Hassan-Ibrahim, David Simpson, Meera Chand, Ravi Gupta, Alistair C. Darby, Steve Paterson, Oliver G. Pybus, Erik Volz, Daniela De Angelis, David L. Robertson, Iñigo Martincorena, Louise Aigrain, Andrew R. Bassett, Nick Wong, Yusri Taha, Michelle J. Erkiert, Michael H. Spencer Chapman, Rebecca Dewar, M. McHugh, Siddharth Mookerjee, Stephen Aplin, Matthew Harvey, Thea Sass, Helen Umpleby, Helen Wheeler, James McKenna, Ben Warne, Joshua F. Taylor, Yasmin Chaudhry, Rhys Izuagbe, Aminu S. Jahun, Gregory R. Young, Claire McMurray, Clare M. McCann, Andrew Nelson, Scott Elliott, Hannah Lowe, Anna Price, Matthew Crown, Sara Rey, Sunando Roy, Ben Temperton, Sharif Shaaban, Andrew R. Hesketh, Kenneth G. Laing, Irene M. Monahan, Judith Heaney, Emanuela Pelosi, Siona Silviera, Eleri Wilson-Davies, Helen Fryer, Helen Adams, Louis du Plessis, Rob Johnson, William T. Harvey, Joseph Hughes, Richard Orton, Lewis G. Spurgin, Yann Bourgeois, Chris Ruis, Áine O’Toole, Marina Gourtovaia, Theo Sanderson, Christophe Fraser, Jonathan Edgeworth, Judith Breuer, Stephen L. Michell, John A. Todd, John P.T. Mo, David Buck, Kavitha Gajee, Gemma L. Kay, Sharon J. Peacock, David Heyburn, Katie Kitchman, Alan McNally, David T. Pritchard, Samir Dervisevic, Peter Muir, Esther Robinson, Barry Vipond, Newara Ramadan, Christopher Jeanes, Danni Weldon, Jana Catalan, Neil Jones, Ana da Silva Filipe, Chris Williams, Marc Fuchs, Julia Miskelly, Aaron R. Jeffries, Karen Oliver, Naomi R. Park, Amy Ash, Cherian Koshy, Magdalena Barrow, Sarah L. Buchan, Anna Mantzouratou, Gemma Clark, Christopher W. Holmes, Stephen Campbell, Thomas Davis, Ngee Keong Tan, Julianne R. Brown, Kathryn Harris, Stephen P. Kidd, Paul R. Grant, Li Xu-McCrae, Alison Cox, Pinglawathee Madona, Marcus Pond, Paul Randell, Karen T. Withell, Cheryl Williams, Clive Graham, Rebecca Denton-Smith, Emma Swindells, Robyn Turnbull, Tim J. Sloan, Andrew Bosworth, Stephanie Hutchings, Hannah M. Pymont, Anna Casey, Liz Ratcliffe, Christopher R. Jones, Bridget Knight, Tanzina Haque, Jennifer Hart, Dianne Irish-Tavares, Eric Witele, Craig Mower, Louisa K. Watson, Jennifer Collins, Gary Eltringham, Dorian Crudgington, Ben Macklin, Miren Iturriza‐Gómara, Anita O. Lucaci, C. Patrick McClure, Matthew Carlile, Nadine Holmes, Christopher Moore, Nathaniel Storey, Stefan Rooke, Gonzalo Yebra, Noel Craine, Malorie Perry, Nabil-Fareed Alikhan, Stephen Bridgett, Kate F. Cook, Christopher Fearn, Salman Goudarzi, Ronan A Lyons, Thomas Williams, Sam Haldenby, Jillian Durham, Steven N. Leonard, Robert M. Davies, Rahul Batra, Beth Blane, Moira J. Spyer, Perminder Smith, Mehmet Yavus, Rachel Williams, Adhyana I. K. Mahanama, Buddhini Samaraweera, Sophia T. Girgis, Samantha E. Hansford, Angie Green, Charlotte Beaver, Katherine L. Bellis, Matthew J. Dorman, Sally Kay, Liam Prestwood, Shavanthi Rajatileka, Joshua Quick, Radoslaw Poplawski, Nicola Reynolds, Andrew Mack, Arthur Morriss, Thomas Whalley, Bindi Patel, Iliana Georgana, Myra Hosmillo, Malte L. Pinckert, Joanne Stockton, John Henderson, Amy Hollis, William T. Stanley, Wen C. Yew, Richard Myers, Alicia Thornton, Alexander Adams, Tara Annett, Hibo Asad, Alec Birchley, Jason Coombes, Johnathan M. Evans, Laia Fina, Bree Gatica-Wilcox, Lauren Gilbert, Lee Graham, Jessica Hey, Ember Hilvers, Sophie Jones,
Abstract Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods We present phylogenetic relationships and lineage dynamics ...
BioMed Central
Kerstin Kläser, Erika Molteni, Mark S. Graham, Liane S. Canas, Marc F. Österdahl, Michela Antonelli, Liyuan Chen, Jie Deng, Benjamin Murray, Eric Kerfoot, Jonathan Wolf, Anna May, Ben Fox, Joan Capdevila Pujol, David M. Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S. Y. Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Adrienn Angyal, Tara Annett, Stephen Aplin, Cristina V. Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W. Attwood, Cressida Auckland, Alp Aydin, David Baker, Paul Baker, Carlos E. Balcazar, Jonathan K. Ball, Jeffrey C. Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R. Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Andrew D. Beggs, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Alice Broos, Julianne R. Brown, Giselda Bucca, Sarah L. Buchan, David Buck, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Sharon L. Campbell, Alessandro M. Carabelli, James S. Cargill, Matthew Carlile, Silvia Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol Churcher, Gemma Clark, Phillip Clarke, Benjamin J. Cogger, Kevin D. Cole, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Kate F. Cook, Jason D. Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D. Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C. Darby, Rose K. Davidson, Alisha Davies, Robert M. Davies, Thomas P. Davis, Daniela De Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Thushan I. de Silva, Johnny Debebe, Rebecca Denton-Smith, Samir Dervisevic, Rebecca Dewar, Jayasree Dey, Joana Dias, Donald Dobie, Matthew J. Dorman, Fatima Downing, Megan Driscoll, Louis du Plessis, Nichola Duckworth, Jillian Durham, Kirstine Eastick, Lisa J. Easton, Richard Eccles, Jonathan D. Edgeworth, Sue Edwards, Kate El Bouzidi, Sahar Eldirdiri, Nicholas Ellaby, Scott Elliott, Gary Eltringham, Leah Ensell, Michelle J. Erkiert, Marina Escalera Zamudio, Sarah Essex, Johnathan M. Evans, Cariad Evans, William V. Everson, Derek Fairley, Karlie Fallon, Arezou Fanaie, Ben W. Farr, Christopher Fearn, Theresa Feltwell, Lynne Ferguson, Laia Fina, Flavia Flaviani, Vicki M. Fleming, Stephen R. Forrest, Ebenezer Foster-Nyarko, Benjamin H. Foulkes, Luke Foulser, Mireille Fragakis, Dan Frampton, Sarah François, Christophe Fraser, Timothy M. Freeman, Helen Fryer, Marc Fuchs, William Fuller, Kavitha Gajee, Katerina Galai, Abbie Gallagher, Eileen Gallagher, Michael D. Gallagher, Marta Gallis, Amy Gaskin, Bree Gatica-Wilcox, Lily Geidelberg, Matthew Gemmell, Iliana Georgana, Ryan P. George, Laura Gifford, Lauren Gilbert, Sophia T. Girgis, Sharon Glaysher, Emily J. Goldstein, Tanya Golubchik, Andrea N. Gomes, Sónia Gonçalves, Ian Goodfellow, Scott Goodwin, Salman Goudarzi, Marina Gourtovaia, Clive Graham, Lee Graham, Paul R. Grant, Luke R. Green, Angie Green, Jane Greenaway, Richard I. Gregory, Martyn F. Guest, Rory Gunson, Ravindra K. Gupta, Bernardo Gutiérrez, Sam Haldenby, William L. Hamilton, Samantha E. Hansford, Tanzina Haque, Kathryn Harris, Ian Harrison, Ewan M. Harrison, Jennifer Hart, John A. Hartley, William T. Harvey, M J Harvey, Mohammed O. Hassan-Ibrahim, Judith Heaney, Thomas Helmer, John Henderson, Andrew R. Hesketh, Jessica Hey, David Heyburn, Ellen E. Higginson, Verity Hill, Jack Hill, Rachel A. Hilson, Ember Hilvers, Matthew T. G. Holden, Amy Hollis, Christopher W. Holmes, Nadine Holmes, Alison Holmes, Richard Hopes, Hailey Hornsby, Myra Hosmillo, Catherine Houlihan, Hannah C. Howson‐Wells, Sharon N. Hsu, Jonathan Hubb, Hannah Huckson, Warwick Hughes, Joseph Hughes, Margaret Hughes, Stephanie Hutchings, Giles Idle, Chris J. Illingworth, Robert Impey, Dianne Irish-Tavares, Miren Iturriza-Gomara, Rhys Izuagbe, Christopher Jackson, Ben Jackson, Leigh Jackson, Kathryn Jackson, David K. Jackson, Aminu S. Jahun, Victoria James, Keith James, Christopher Jeanes, Aaron R. Jeffries, Sarah Jeremiah, Andrew Jermy, John P.T. Mo, Rob Johnson, KATE JOHNSON,
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December ...
Nature Portfolio
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola S. Logan, Shirin Ashraf, Maria Manali, Agnieszka M. Szemiel, Vanessa M. Cowton, Elen Vink, William T. Harvey, Christopher Davis, Patawee Asamaphan, Katherine Smollett, L. Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, Susanna Dunachie, Paul Klenerman, Eleanor Barnes, Anthony Brown, Sandra Adele, Barbara Kronsteiner, Sam M. Murray, Priyanka Abraham, Alexandra Deeks, M. Azim Ansari, Thushan I. de Silva, Lance Turtle, Shona C. Moore, James E. Austin, Alexander Richter, C.J. Duncan, Rebecca Payne, Amy Ash, Cherian Koshy, Beatrix Kele, Teresa Cutiño‐Moguel, Derek Fairley, James P. McKenna, Tanya Curran, Helen Adams, Christophe Fraser, David Bonsall, Helen Fryer, Katrina Lythgoe, Emma C. Thomson, Tanya Golubchik, Abigail Murray, Dawn Singleton, Shaun M. Beckwith, Anna Mantzouratou, Magdalena Barrow, Sarah L. Buchan, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Siân Morgan, Andrew Mack, Angela Marchbank, Anna Price, Arthur Morriss, Catherine Bresner, Christine Kitchen, Ian Merrick, Joel Southgate, Martyn F. Guest, Owen Jones, R. W. Munn, Thomas R. Connor, Thomas Whalley, Trudy Workman, William Fuller, Amita Patel, Bindi Patel, Gaia Nebbia, Jonathan D. Edgeworth, Luke B. Snell, Rahul Batra, Themoula Charalampous, Angela H. Beckett, Ekaterina Shelest, Samuel C. Robson, Anthony P. Underwood, Ben Taylor, Corin Yeats, David M. Aanensen, Khalil Abudahab, Mirko Menegazzo, Amelia Joseph, Gemma Clark, Hannah C. Howson‐Wells, Louise Berry, Manjinder Khakh, Michelle M. Lister, Tim Boswell, Vicki M. Fleming, Christopher W. Holmes, Claire McMurray, Jessica Shaw, Julian W. Tang, Karlie Fallon, Mina Odedra, Nicholas J. Willford, Paul Bird, Thomas Helmer, Lesley-Anne Williams, Nicola Sheriff, Sharon L. Campbell, Veena Raviprakash, Victoria Blakey, C. J. Moore, Fei Sang, Johnny Debebe, Matthew Carlile, Matthew Loose, Nadine Holmes, Victoria Wright, M. Estee Torok, William L. Hamilton, Alessandro M. Carabelli, Andrew Jermy, Beth Blane, Carol Churcher, Catherine Ludden, Dinesh Aggarwal, Elaine Westwick, Ellena Brooks, Georgina M. McManus, Katerina Galai, Ken R. Smith, Kim S. Smith, MacGregor Cox, Mireille Fragakis, Patrick H. Maxwell, Sarah Judges, Sharon J. Peacock, Theresa Feltwell, Anita Kenyon, Sahar Eldirdiri, Thomas P. Davis, Joshua F. Taylor, Ngee Keong Tan, Alex E. Zarebski, Bernardo Gutiérrez, Jayna Raghwani, Louis du Plessis, Moritz U. G. Kraemer, Oliver G. Pybus, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Aminu S. Jahun, Ian Goodfellow, Iliana Georgana, Malte L. Pinckert, Myra Hosmillo, Rhys Izuagbe, Yasmin Chaudhry, Felicity Ryan, Hannah Lowe, Samuel Moses, Luke Bedford, James S. Cargill, Warwick Hughes, Jonathan D. Moore, Susanne Stonehouse, Divya Shah, Jack C. D. Lee, Julianne R. Brown, Kathryn Harris, Laura Atkinson, Nathaniel Storey, Moira J. Spyer, Flavia Flaviani, Adela Alcolea-Medina, Jasveen Sehmi, John Ramble, Natasha Ohemeng-Kumi, Perminder Smith, Beatrice Bertolusso, Claire Thomas, Gabrielle Vernet, Jessica Lynch, Nathan Moore, Nicholas Cortes, Rebecca Williams, Stephen P. Kidd, Lisa J. Levett, Monika Pusok, Paul R. Grant, Stuart A. Kirk, Wendy Chatterton, Li Xu-McCrae, Darren Smith, Gregory R. Young, Matthew Bashton, Katie Kitchman, Kavitha Gajee, Kirstine Eastick, Patrick Lillie, Phillipa Burns, William V. Everson, Alison Cox, Alison Holmes, Frances Bolt, James Price, Marcus Pond, Paul Randell, Pinglawathee Madona, Siddharth Mookerjee, Erik Volz, Lily Geidelberg, Manon Ragonnet‐Cronin, Olivia Boyd, Rob Johnson, Cassie F. Pope, Adam A. Witney, Irene M. Monahan, Kenneth G. Laing, Katherine Smollett, Alan McNally, Claire McMurray, Joanne Stockton, Joshua Quick, Nicholas J. Loman, Radoslaw Poplawski, Samuel M. Nicholls, Will Rowe, Anibolina Castigador, Emily MacNaughton, Kate El Bouzidi, Malur Sudhanva, Temi Lampejo, Rocio T. Martinez Nunez, Cassie Breen, Graciela Sluga, Karen T. Withell, Nicholas W. Machin, Ryan P. George, Shazaad S. Y. Ahmad, David T. Pritchard, Debbie Binns, Nicholas C. Wong, Victoria James, Cheryl Williams, Chris J. Illingworth, Christopher Jackson, Daniela De Angelis, David J. Pascall, Afrida Mukaddas, Alice Broos, Ana da Silva Filipe, Daniel Mair, David L. Robertson, Derek Wright, Emma C. Thomson, Igor Starinskij, Ioulia Tsatsani, James G. Shepherd, Jenna Nichols, Joseph Hughes, Kyriaki Nomikou, L. Tong, Richard Orton, Vattipally B. Sreenu, William T. Harvey, Roy Sanderson, Sarah H. O’Brien, Steven Rushton, Jon Perkins, Rachel Blacow,
Nature Portfolio
Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan, Shirin Ashraf, Maria Manali, Agnieszka M. Szemiel, Vanessa M. Cowton, Elen Vink, William T. Harvey, Christopher Davis, Patawee Asamaphan, Katherine Smollett, L. Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, Susanna Dunachie, Paul Klenerman, Eleanor Barnes, Anthony Brown, Sandra Adele, Barbara Kronsteiner, Sam M. Murray, Priyanka Abraham, Alexandra Deeks, M. Azim Ansari, Thushan I. de Silva, Lance Turtle, Shona C. Moore, James Austin, Alex Richter, C.J. Duncan, Rebecca P. Payne, Amy Ash, Cherian Koshy, Beatrix Kele, Teresa Cutiño‐Moguel, Derek Fairley, James P. McKenna, Tanya Curran, Helen Adams, Christophe Fraser, David Bonsall, Helen Fryer, Katrina Lythgoe, Emma C. Thomson, Tanya Golubchik, Abigail Murray, Dawn Singleton, Shaun M. Beckwith, Anna Mantzouratou, Magdalena Barrow, Sarah L. Buchan, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Sian Morgan, Andrew Mack, Angela Marchbank, Anna Price, Arthur Morriss, Catherine Bresner, Christine Kitchen, Ian Merrick, Joel Southgate, Martyn F. Guest, Owen Jones, Robert J. Munn, Thomas R. Connor, Thomas Whalley, Trudy Workman, William Fuller, Amita Patel, Bindi Patel, Gaia Nebbia, Jonathan Edgeworth, Luke B. Snell, Rahul Batra, Themoula Charalampous, Angela H. Beckett, Ekaterina Shelest, Samuel C. Robson, Anthony P. Underwood, Ben Taylor, Corin Yeats, David M. Aanensen, Khalil Abudahab, Mirko Menegazzo, Amelia Joseph, Gemma Clark, Hannah C. Howson‐Wells, Louise Berry, Manjinder Khakh, Michelle M. Lister, Tim Boswell, Vicki M. Fleming, Christopher W. Holmes, Claire McMurray, Jessica Shaw, Julian W. Tang, Karlie Fallon, Mina Odedra, Nicholas J. Willford, Paul Bird, Thomas Helmer, Lesley-Anne Williams, Nicola Sheriff, Stephen Campbell, Veena Raviprakash, Victoria Blakey, Christopher Moore, Fei Sang, Johnny Debebe, Matthew Carlile, Matthew Loose, Nadine Holmes, Victoria Wright, M. Estee Torok, William L. Hamilton, Alessandro M. Carabelli, Andrew Jermy, Beth Blane, Carol Churcher, Catherine Ludden, Dinesh Aggarwal, Elaine Westwick, Ellena Brooks, Georgina M. McManus, Katerina Galai, Kenneth G. C. Smith, Kim S. Smith, MacGregor Cox, Mireille Fragakis, Patrick H. Maxwell, Sarah Judges, Sharon J. Peacock, Theresa Feltwell, Anita Kenyon, Sahar Eldirdiri, Thomas Davis, Joshua F. Taylor, Ngee Keong Tan, Alex E. Zarebski, Bernardo Gutiérrez, Jayna Raghwani, Louis du Plessis, Moritz U. G. Kraemer, Oliver G. Pybus, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Aminu S. Jahun, Ian Goodfellow, Iliana Georgana, Malte L. Pinckert, Myra Hosmillo, Rhys Izuagbe, Yasmin Chaudhry, Felicity Ryan, Hannah Lowe, Samuel Moses, Luke Bedford, James S. Cargill, Warwick Hughes, Jonathan P. Moore, Susanne Stonehouse, Divya Shah, Jack C. D. Lee, Julianne R. Brown, Kathryn Harris, Laura Atkinson, Nathaniel Storey, Moira J. Spyer, Flavia Flaviani, Adela Alcolea-Medina, Jasveen Sehmi, John Ramble, Natasha Ohemeng-Kumi, Perminder Smith, Beatrice Bertolusso, Claire Thomas, Gabrielle Vernet, Jessica Lynch, Nathan Moore, Nicholas Cortes, Rebecca Williams, Stephen P. Kidd, Lisa J. Levett, Monika Pusok, Paul R. Grant, Stuart A. Kirk, Wendy Chatterton, Li Xu-McCrae, Darren Smith, Gregory R. Young, Matthew Bashton, Katie Kitchman, Kavitha Gajee, Kirstine Eastick, Patrick Lillie, Phillipa Burns, William V. Everson, Alison Cox, Alison Holmes, Frances Bolt, James Price, Marcus Pond, Paul Randell, Pinglawathee Madona, Siddharth Mookerjee, Erik Volz, Lily Geidelberg, Manon Ragonnet‐Cronin, Olivia Boyd, Rob Johnson, Cassie F. Pope, Adam A. Witney, Irene M. Monahan, Kenneth G. Laing, Katherine Smollett, Alan McNally, Claire McMurray, Joanne Stockton, Joshua Quick, Nicholas J. Loman, Radoslaw Poplawski, Samuel M. Nicholls, Will Rowe, Anibolina Castigador, Emily MacNaughton, Kate El Bouzidi, Malur Sudhanva, Temi Lampejo, Rocio T. Martinez Nunez, Cassie Breen, Graciela Sluga, Karen T. Withell, Nicholas W. Machin, Ryan P. George, Shazaad S. Y. Ahmad, David T. Pritchard, Debbie Binns, Nick Wong, Victoria James, Cheryl Williams, Chris J. Illingworth, Christopher Jackson, Daniela De Angelis, David J. Pascall, Afrida Mukaddas, Alice Broos, Ana da Silva Filipe, Daniel Mair, David L. Robertson, Derek Wright, Emma C. Thomson, Igor Starinskij, Ioulia Tsatsani, James G. Shepherd, Jenna Nichols, Joseph Hughes, Kyriaki Nomikou, L. Tong, Richard Orton, Vattipally B. Sreenu, William T. Harvey, Roy Sanderson, Sarah H. O’Brien, Steven Rushton, Jon Perkins, Rachel Blacow,
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals ...
Nature Portfolio
Thushan I. de Silva, Guihai Liu, Benjamin B. Lindsey, Danning Dong, Shona C. Moore, Sharon Hsu, Dhruv R. Shah, Dannielle Wellington, Alexander J. Mentzer, Adrienn Angyal, Rebecca Brown, Matthew Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K. Maini, Graham S. Ogg, Julian C. Knight, Yanchun Peng, Sarah L. Rowland-Jones, Tao Dong, David M. Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S.Y. Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Tara Annett, Stephen Aplin, Cristina V. Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W. Attwood, Cressida Auckland, Alp Aydin, David Baker, Paul Baker, Carlos E. Balcazar, Jonathan Ball, Jeffrey C. Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R. Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Andrew D. Beggs, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David C. Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan T. Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Alice Broos, Julianne R. Brown, Giselda Bucca, Sarah L. Buchan, David Buck, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Stephen Campbell, Alessandro M. Carabelli, James S. Cargill, Matthew Carlile, Silvia Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol Churcher, Gemma Clark, Philip Clarke, Benjamin J. Cogger, Kevin D. Cole, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Kate F. Cook, Jason D. Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D. Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C. Darby, Rose K. Davidson, Alisha Davies, Robert M. Davies, Thomas P. Davis, Daniela De Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Johnny Debebe, Rebecca Denton-Smith, Samir Dervisevic, Rebecca Dewar, Jayasree Dey, Joana Dias, Donald Dobie, Matthew J. Dorman, Fatima Downing, Megan Driscoll, Louis du Plessis, Nichola Duckworth, Jillian Durham, Kirstine Eastick, Lisa J. Easton, Richard Eccles, Jonathan Edgeworth, Sue Edwards, Kate El Bouzidi, Sahar Eldirdiri, Nicholas Ellaby, Scott Elliott, Gary Eltringham, Leah Ensell, Michelle J. Erkiert, Marina Escalera Zamudio, Sarah Essex, Johnathan M. Evans, Cariad Evans, William V. Everson, Derek Fairley, Karlie Fallon, Arezou Fanaie, Ben W. Farr, Christopher Fearn, Theresa Feltwell, Lynne Ferguson, Laia Fina, Flavia Flaviani, Vicki M. Fleming, Stephen R. Forrest, Ebenezer Foster-Nyarko, Benjamin H. Foulkes, Luke Foulser, Mireille Fragakis, Dan Frampton, Sarah François, Christophe Fraser, Timothy M. Freeman, Helen Fryer, Marc Fuchs, William Fuller, Kavitha Gajee, Katerina Galai, Abbie Gallagher, Eileen Gallagher, Eileen Gallagher, Marta Gallis, Amy Gaskin, Bree Gatica-Wilcox, Lily Geidelberg, Matthew Gemmell, Iliana Georgana, Ryan P. George, Laura Gifford, Lauren Gilbert, Sophia T. Girgis, Sharon Glaysher, Emily J. Goldstein, Tanya Golubchik, Andrea N. Gomes, Sónia Gonçalves, Ian Goodfellow, Scott Goodwin, Salman Goudarzi, Marina Gourtovaia, Clive Graham, Lee Graham, Paul R. Grant, Luke R. Green, Angie Green, Jane Greenaway, Richard D. Gregory, Martyn F. Guest, Rory Gunson, Ravi Kumar Gupta, Bernardo Gutiérrez, Sam Haldenby, William L. Hamilton, Samantha E. Hansford, Tanzina Haque, Kathryn Harris, Ian Harrison, Ewan M. Harrison, Jennifer Hart, John A. Hartley, William T. Harvey, M J Harvey, Mohammed O. Hassan-Ibrahim, Judith Heaney, Thomas Helmer, John Henderson, Andrew R. Hesketh, Jessica Hey, David Heyburn, Ellen E. Higginson, Verity Hill, Jack D. Hill, Rachel A. Hilson, Ember Hilvers, Matthew T. G. Holden, Amy Hollis, Christopher W. Holmes, Nadine Holmes, Alison Holmes, Richard Hopes, Hailey Hornsby, Myra Hosmillo, Catherine Houlihan, Hannah C. Howson‐Wells, Jonathan Hubb, Hannah Huckson, Warwick Hughes, Joseph Hughes, Margaret Hughes, Stephanie Hutchings, Giles Idle, Chris J. Illingworth, Robert Impey, Dianne Irish-Tavares, Miren Iturriza-Gomara, Rhys Izuagbe, Christopher Jackson, Ben Jackson, Leigh Jackson, Kathryn Jackson, David K. Jackson, Aminu S. Jahun, Victoria James, Keith James, Christopher Jeanes, Aaron R. Jeffries,
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted ...
Cell Press