Igor Czerski, Arkadiusz Listkowski, Jan Nawrocki, Natalia Urbańska, Hubert Piwoński, Adam Sokołowski, Oksana Pietraszkiewicz, Marek Pietraszkiewicz, Jacek Waluk,
We describe attempts — not always successful — made over the years to improve the efficiency of porphycene synthesis and to produce novel compounds, custom-designed for specific purposes. New porphycenes are reported, some of them obtained rather unexpectedly as by-products of the planned reactions. Structure and energy computations of possible tautomeric forms in porphycenes substituted by one, two, three, and four tert-butyl groups lead to predictions regarding the kinetics and mechanisms of intramolecular ...
Tópico(s): Surface Chemistry and Catalysis
2012 - World Scientific | Journal of Porphyrins and Phthalocyanines
Siddharth Talapatra, James M. Sullivan, Joseph Katz, Michael Twardowski, Helen Czerski, Percy L. Donaghay, Jiarong Hong, Jan Rines, Malcolm McFarland, Aditya R. Nayak, Zhang Cao,
The link between suspended particle fields, particle dynamics and bulk optical properties in natural waters is poorly known because adequate technology is lacking to fully characterize critical parameters and interactions, especially for ephemeral bubbles and aggregates. This paper highlights the capabilities of digital holography to provide non-intrusive, high-resolution 3-D imaging of particles and bubbles in their natural environment. As part of a NOPP project (HOLOCAM) to commercialize an in- ...
Tópico(s): Underwater Acoustics Research
2012 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
A. Czerski, Jan Gnus, Willy Hauzer, Kornel Ratajczak, Wojciech Zawadzki, Wojciech Witkiewicz, Stanisław Ferenc, Agnieszka Rusiecka, Maciej Janeczek,
The study was conducted on 5 pigs weighing 20–30 kg. Bipolar electrodes were surgically implanted into the muscular layer of the vascular smooth muscle cell of the abdominal aorta just below the renal arteries. Myoelectric activity characterized by the appearance of changes of membrane potential was found. Changes of potential could be divided according to the amplitude, duration and frequency into first-, second- and third-order waves. First-order waves appeared with a mean frequency of 128 ± 14/ ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2012 - University of Veterinary and Pharmaceutical Sciences, Brno | Acta Veterinaria Brno
Tópico(s): Historical and Archaeological Studies
1968 - Wydawnictwo Uniwersytetu Jagiellońskiego | Kwartalnik Historii Nauki i Techniki
H. Jammet, J. Bernhardt, B. F M Bosnjakovic, P Czerski, M. Grandolfo, D. Harder, Bengt Knave, N. Justin Marshall, Michael H. Repacholi, D.H. Sliney, Jan A. J. Stolwijk, Alexandre Duchêne,
Tópico(s): Transportation Systems and Safety
1988 - Lippincott Williams & Wilkins | Health Physics
D. Böhm, K. Czerski, A. Huke, Jan-Christian Lewitz, Daniel Weißbach, Stephan Gottlieb, G. Ruprecht,
The 2019 Mazurian Lakes Conference on Physics was held in Piaski, a vacation resort located at the lake of Bełdany in the heart of the Great Mazurian Lakes District, from the 1 st to 7 th of September 2019.It was the 36 th meeting in a series initiated over 50 years ago, in 1968, by Professor Zdzisław Wilhelmi and his students and collaborators.Throughout these years, the Mazurian conferences have gained a world-wide reputation for their high scientific merit and a unique atmosphere.
Tópico(s): Nuclear Materials and Properties
2020 - Jagiellonian University | Acta Physica Polonica B
Ann Van Den Bogaert, Johannes Schumacher, Thomas G. Schulze, A Otte, Stephanie Ohlraun, S. S. Kovalenko, Tim Becker, Jan Freudenberg, Erik G. Jönsson, Marja Mattila‐Evenden, Göran C. Sedvall, Piotr M. Czerski, Paweł Kapelski, Joanna Hauser, Wolfgang Maier, Marcella Rietschel, Peter Propping, Markus M. Nöthen, Sven Cichon,
We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of subjects with schizophrenia and unaffected control subjects of German (418 cases, 285 controls), Polish (294 cases, 113 controls), and Swedish (142 cases, 272 controls) descent. We analyzed five single-nucleotide polymorphisms (P1635, P1325, P1320, P1757, and P1578) and identified significant evidence of association ...
Tópico(s): Diet and metabolism studies
2003 - Elsevier BV | The American Journal of Human Genetics
Jan Gnus, A. Czerski, Stanisław Ferenc, Wojciech Zawadzki, Wojciech Witkiewicz, Agnieszka Rusiecka, Jolanta Bujok, Willy Hauzer, Maciej Janeczek, Aleksander Chrószcz,
Investigation of the effect of α 1 -adrenergic receptor subtypes on the contraction of the abdominal aorta will allow for more effective treatment of hypertension by use of selective antagonists. The aim of the study was to evaluate the participation of α 1 -adrenergic receptor subtypes in the contractility of the aortic smooth muscle cells in rabbits. The in vitro experiments were performed in isolated tissue preparations from 30 adult female New Zealand rabbits. The abdominal aortic sections were ...
Tópico(s): Hormonal Regulation and Hypertension
2013 - University of Veterinary and Pharmaceutical Sciences, Brno | Acta Veterinaria Brno
Jan Gnus, A. Czerski, Wojciech Zawadzki, Wojciech Witkiewicz, Willy Hauzer, Agnieszka Rusiecka, Stanisław Ferenc,
The objective of the study was to demonstrate spontaneous contractile activity of the smooth muscle coat of the aorta in human and animal material. Spontaneous contractility of smooth muscle tissue, or tonus, is essential for the proper function of many internal organs as observed in the many types of muscle cells which make up the internal structures. The spontaneous contractile activity of the muscle tissue in blood vessels is particularly marked in resistance vessels, regulating circulation within ...
Tópico(s): Ion Transport and Channel Regulation
2012 - Institute of Systematics and Evolution of Animals, Polish Academy of Sciences | Folia Biologica
Emil Hagström, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Nicolas Danchin, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Evangelos Liberopoulos, Nikolaus Marx, Jennifer McGinniss, Garen Manvelian, Robert Pordy, Michel Scemama, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz, Gregory G. Schwartz, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Díaz, Philip E Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina N Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos, Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Saško Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M Correa Flores, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobantu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean-Lucien Rouleau, Maarten L. Simoons, Karen Alexander, C Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P Bordonava, Alberto E Alves De Lima, Jorge M. Schmidberg, Ernesto A Duronto, Orlando C. Caruso, Leonardo P Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis R Cartasegna, Gustavo A. Paterlini, Ignacio J Mackinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo DS Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E Aylward, Chris LS Hii, Philip E Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantić, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo RF Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler ON de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães,
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab ...
Lippincott Williams & Wilkins
Kausik K Ray, Helen M Colhoun, Michael Szarek, Marie T. Baccara‐Dinet, Deepak L. Bhatt, Vera Bittner, Andrzej Budaj, Rafael Díaz, Shaun G Goodman, Corinne Hanotin, Robert A Harrington, J. Wouter Jukema, Virginie Loizeau, Renato D. Lópes, Angèle Moryusef, Jan Murin, Robert Pordy, Arsen Ristić, Matthew T. Roe, José Tuñón, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D. Lópes, Nina Gotcheva, Juan Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ostadal, Margus Viigimaa, Markku S. Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, K. Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, R. Correa, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen Ristić, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J. Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern‐En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean-Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, David J. Maron, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez‐Pereira, Lynn Perkins, Thomas J. Povsic, Étienne Puymirat, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo DS Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Chris LS Hii, James Shaw, Margaret Arstall, John D. Horowitz, Daniel M. Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, O. Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, G. Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, Etienne Hoffer, Mathias Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantić, Duško Vulić, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo RF Rossi, Maria José AG Cerqueira, Norberto Duda, Renato A. K. Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler ON de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro Silva, José Alexandre Silveira, Wladmir Saporito, José Antônio Marin‐Neto, Gílson Soares Feitosa,
Summary Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in ...
Elsevier BV
Shaun G. Goodman, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Robert A. Harrington, J. Wouter Jukema, Harvey D. White, Andreas M. Zeiher, Garen Manvelian, Robert Pordy, Yann Poulouin, Wanda Stipek, Geneviève Garon, Gregory G. Schwartz, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Dı́az, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Dı́az, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, R. Correa, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, C Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, J. Dedrick Jordan, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F P van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven G M Coverdale, P. Garrahy, G. Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo RF Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro Silva, José Alexandre Silveira, Wladmir Faustino Saporito,
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety ...
Oxford University Press
Gregory G. Schwartz, Michael Szarek, Vera A. Bittner, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Ulf Landmesser, Patricio López‐Jaramillo, Garen Manvelian, Robert Pordy, Michel Scemama, Peter Sinnaeve, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Steg, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Diaz, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D. Lopes, Nina Gotcheva, Shaun G. Goodman, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ošťádal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang-Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M. Correa Flores, Rody G. Sy, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen P. Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lopes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew Tze-Kay Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A. Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, Maria E. Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, O. Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, Etienne Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mirza Dilic, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lilia Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M. Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto V. Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton B. Precoma, José Carlos Moura Jorge, Pedro Silva,
Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) ...
Elsevier BV
Gregory G. Schwartz, Michael Szarek, Vera Bittner, Deepak L. Bhatt, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Megan Loy, Garen Manvelian, Robert Pordy, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ošťádal, Margus Viigimaa, Markku S. Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, R. Correa, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, David J. Maron, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez‐Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G. Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Chris L.S. Hii, James Shaw, Margaret Arstall, John D. Horowitz, Daniel M. Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantić, Duško Vulić, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro G. Silva, José Alexandre Silveira, Wladmir Saporito, José Antônio Marin‐Neto, Gílson Soares Feitosa, Luiz Eduardo Fonteles Ritt, Juliana A. de Souza, Fernando Costa, Weimar K.S.B. Souza, Helder J.L. Reis, Leandro Machado, José Carlos Aidar Ayoub, Georgi V Todorov, Fedya Nikolov, Elena S Velcheva, M. Tzekova, Haralambi O Benov,
OBJECTIVE In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary ...
American Diabetes Association
Nancy E. Simpson, A. C. Turnbull, Duane Alexander, Helen Bantock, Piotr M. Czerski, T.A. Doran, Michael M. Kaback, S Liedgren, Jan-Diether Murken, Sachio Ogita, D. Seigal, Ian Sutherland,
Prenatal DiagnosisVolume 1, Issue 5 p. 5-10 Article Section 1: Genetic amniocentesis N. E. Simpson, N. E. Simpson Co-Chairman.Search for more papers by this authorA. C. Turnbull, A. C. Turnbull Co-Chairman.Search for more papers by this authorD. Alexander, D. AlexanderSearch for more papers by this authorH. Bantock, H. BantockSearch for more papers by this authorP. Czerski, P. CzerskiSearch for more papers by this authorT. A. Doran, T. A. DoranSearch for more papers by this authorM. Kaback, M. KabackSearch ...
Tópico(s): Congenital Anomalies and Fetal Surgery
1981 - Wiley | Prenatal Diagnosis
Jan Gnus, Agnieszka Rusiecka, A. Czerski, Wojciech Zawadzki, Wojciech Witkiewicz, Willy Hauzer,
The aim of the study was to demonstrate the effect of selected agonists and antagonists of alpha-adrenergic receptors on muscle contractility of the rabbit abdominal aorta in vitro with particular emphasis on alpha2-adrenergic receptor subtypes. The study was conducted on 30 New Zealand breed rabbits from which specimens of the abdominal aorta were collected. The sections were set up in an automatic water bath in a Krebs-Henseleit buffer at 37 degrees C. The experiments showed that alpha1-adrenergic ...
Tópico(s): Adipose Tissue and Metabolism
2013 - Institute of Systematics and Evolution of Animals, Polish Academy of Sciences | Folia Biologica
W. Zawadzki, A. Czerski, E. Wincewicz, Jan Gnus, A. Balcerzak, A. Kotecki, M. Kozák,
The objective of the experiments was to demonstrate the influence of low- and high-tannin horse bean on the selected fermentation indicators. The sheep rumen content with the addition of 1, 2 and 5 g of high- and low-tannin horse bean was incubated in vessels of 250 ml volume. A significant increase of ammonia, lactic acid, CO 2 and methane as well as pH decrease in samples with addition of horse bean seed was demonstrated. While comparing high- and low-tannin horse bean varieties, it was observed ...
Tópico(s): Phytoestrogen effects and research
2010 - University of Veterinary and Pharmaceutical Sciences, Brno | Acta Veterinaria Brno
Jonathan R. I. Coleman, Héléna A. Gaspar, Julien Bryois, Gerome Breen, Enda M. Byrne, Andreas J. Forstner, Peter Holmans, Christiaan de Leeuw, Manuel Mattheisen, Andrew McQuillin, Jennifer M. Whitehead Pavlides, Tune H. Pers, Stephan Ripke, Eli A. Stahl, Stacy Steinberg, Vassily Trubetskoy, Maciej Trzaskowski, Yunpeng Wang, Liam Abbott, Abdel Abdellaoui, Mark J. Adams, Annelie Nordin Adolfsson, Esben Agerbo, Huda Akil, Diego Albani, Ney Alliey‐Rodriguez, Thomas D. Als, Till F. M. Andlauer, Adebayo Anjorin, Verneri Antilla, Sandra Van der Auwera, Swapnil Awasthi, Silviu‐Alin Bacanu, Judith A. Badner, Marie Bækvad‐Hansen, Jack D. Barchas, Nicholas Bass, Michael Bauer, Aartjan T.F. Beekman, Richard A. Belliveau, Sarah E. Bergen, Tim B. Bigdeli, Elisabeth B. Binder, Erlend Bøen, Marco P. Boks, James Boocock, Monika Budde, William E. Bunney, Margit Burmeister, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, William Byerley, Na Cai, Miguel Casas, Enrique Castelao, Felecia Cerrato, Pablo Cervantes, Kimberly Chambert, Alexander W. Charney, Danfeng Chen, Jane Christensen, Claire Churchhouse, David St Clair, Toni‐Kim Clarke, Lucía Colodro‐Conde, William Coryell, Baptiste Couvy‐Duchesne, David W. Craig, Gregory E. Crawford, Cristiana Cruceanu, Piotr M. Czerski, Anders M. Dale, Gail Davies, Ian J. Deary, Franziska Degenhardt, Jurgen Del‐Favero, J. Raymond DePaulo, Eske M. Derks, Neşe Direk, Srdjan Djurovic, Amanda Dobbyn, Conor V. Dolan, Ashley Dumont, Erin C. Dunn, Thalia C. Eley, Torbjørn Elvsåshagen, Valentina Escott‐Price, Chun Chieh Fan, Hilary K. Finucane, Sascha B. Fischer, Matthew Flickinger, Jerome C. Foo, Tatiana Foroud, Liz Forty, Josef Frank, Christine Fraser, Nelson B. Freimer, Louise Frisén, Katrin Gade, Diane Gage, Julie Garnham, Claudia Giambartolomei, Fernando S. Goes, Jaqueline Goldstein, Scott D. Gordon, Katherine Gordon‐Smith, Elaine Green, Melissa J. Green, Tiffany A. Greenwood, Jakob Grove, Weihua Guan, Lynsey S. Hall, Marian L. Hamshere, Christine Søholm Hansen, Thomas Hansen, Martin Hautzinger, Urs Heilbronner, Albert M. van Hemert, Stefan Herms, Ian B. Hickie, Maria Hipolito, Per Hoffmann, Dominic Holland, Georg Homuth, Carsten Horn, Jouke‐Jan Hottenga, Laura M. Huckins, Marcus Ising, Stéphane Jamain, Rick Jansen, Jessica Johnson, Simone de Jong, Eric Jorgenson, Anders Juréus, Radhika Kandaswamy, Robert Karlsson, James L. Kennedy, Farnush Farhadi Hassan Kiadeh, Sarah Kittel‐Schneider, James A. Knowles, Manolis Kogevinas, Isaac S. Kohane, Anna C. Koller, Julia Kraft, Warren W. Kretzschmar, Jesper Krogh, Ralph Kupka, Zoltán Kutalik, Catharina Lavebratt, Jacob Lawrence, William Lawson, Markus Leber, Phil H. Lee, Shawn Levy, Jun Z. Li, Yihan Li, Penelope A. Lind, Chunyu Liu, Loes M. Olde Loohuis, Anna Maaser, Donald J. MacIntyre, Dean F. MacKinnon, Pamela B. Mahon, Wolfgang Maier, Robert Maier, Jonathan Marchini, Lina Martinsson, Hamdi Mbarek, Steve McCarroll, Patrick J. McGrath, Peter McGuffin, Melvin G. McInnis, James McKay, Helena Medeiros, Sarah E. Medland, Divya Mehta, Fan Meng, Christel M. Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Saira Saeed Mirza, Francis M. Mondimore, Grant W. Montgomery, Derek W. Morris, Sara Mostafavi, Thomas W. Mühleisen, Niamh Mullins, Matthias Nauck, Bernard Ng, Hoang Nguyen, Caroline M. Nievergelt, Michel G. Nivard, Evaristus A. Nwulia, Dale R. Nyholt, Claire O’Donovan, Paul F. O’Reilly, Anil P. S. Ori, Lilijana Oruč, Urban Ösby, Högni Óskarsson, Jodie N. Painter, José Guzmán‐Parra, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Amy Perry, Roseann E. Peterson, Erik Pettersson, Wouter J. Peyrot, Andrea Pfennig, Giorgio Pistis, Shaun Purcell, Jorge A. Quiroz, Per Qvist, Eline J. Regeer, Andreas Reif, Céline S. Reinbold, John P. Rice, Brien P. Riley, Fabio Rivas, Margarita Rivera, Panos Roussos, Douglas M. Ruderfer, Euijung Ryu, Cristina Sánchez‐Mora, Alan F. Schatzberg, William A. Scheftner, Robert A. Schoevers, Nicholas J. Schork, Eva C. Schulte, Tatyana Shehktman, Ling Shen, Jianxin Shi, Paul D. Shilling, Stanley I. Shyn, Engilbert Sigurðsson, Claire Slaney, Olav B. Smeland, Johannes H. Smit, Daniel J. Smıth, Janet L. Sobell, Anne T. Spijker, Michael Steffens, John S. Strauss, Fabian Streit, Jana Strohmaier, Szabolcs Szelinger, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Robert C. Thompson, Wesley K. Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, André G. Uitterlinden, Daniel Umbricht, Helmut Vedder, Alexander Viktorin, Peter M. Visscher, Weiqing Wang, Stanley J. Watson, Bradley T. Webb, Cynthia Shannon Weickert, Thomas W. Weickert, Shantel Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H. Witt, Yang Wu, Hualin Simon Xi, Wei Xu, Jian Yang, Allan H. Young, Peter P. Zandi, Peng Zhang, Futao Zhang, Sebastian Zöllner, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Volker Arolt, Lena Backlund, Bernhard T. Baune, Frank Bellivier, Kenneth I. Berger, Wade H. Berrettini, Joanna M. Biernacka, Douglas Blackwood, Michael Boehnke, Dorret I. Boomsma, Aiden Corvin, Nicholas John Craddock, Mark J. Daly, Udo Dannlowski,
Background Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. Methods To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, ...
Elsevier BV
Helmut Klein, Robert B. Karp, Nicholas T. Kouchoukos, Gerlinde Zorn, Thomas N. James, Albert L. Waldo,
... 407-413), . Göudde P, Agrawal R, Müuller H, Czerski K, Endt P, Steinhoff U, Oeff M, Schultheiss ... 53:7, (932-939), Online publication date: 1-Jan-2000. Sanner B, Zidek W, Laschewski F, Sevecke- ... 2:1, (20-26), Online publication date: 1-Jan-1997. Ducceschi V, Sarubbi B, Briglia N, Santangelo ... 71:2, (251-253), Online publication date: 1-Jan-1993. Mackall J, Waldo A and Rosenbaum D ( ... 85:1, (158-163), Online publication date: 1-Jan-1992. Branyas N, Cassidy D and Cain M ( ... 66:1, (55-68), Online publication date: 1-Jan-1990. KLITZNER T and STEVENSON W (1990) Effects ...
Tópico(s): ECG Monitoring and Analysis
1982 - Lippincott Williams & Wilkins | Circulation
Willy Hauzer, Jolanta Bujok, A. Czerski, Agnieszka Rusiecka, E. Pecka, Jan Gnus, Wojciech Zawadzki, Wojciech Witkiewicz,
β-adrenergic receptors (β-AR) are widely distributed in the cardiovascular system, where they considerably contribute to the control of its functions. β-blockers are commonly used in the treatment of disorders of the circulatory system. They act primarily by inhibiting cardiac β-receptors. However, there are also reports of pleiotropic action of β-blockers as well as of new compounds created to study β3 adrenergic receptors. The study aimed to investigate additional mechanisms of action of β-AR inhibitors ...
Tópico(s): Pharmacological Effects and Assays
2014 - Institute of Systematics and Evolution of Animals, Polish Academy of Sciences | Folia Biologica
Verneri Anttila, Brendan Bulik‐Sullivan, Hilary K. Finucane, Raymond K. Walters, José Brás, Laramie E. Duncan, Valentina Escott‐Price, Guido J. Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A. Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H. Lee, Patrick Turley, Benjamin Grenier‐Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland, Jean‐François Deleuze, Emmanuelle Duron, Badri N. Vardarajan, Christiane Reitz, Alison Goate, Matthew J. Huentelman, M. Ilyas Kamboh, Eric B. Larson, Ekaterina Rogaeva, Peter St George‐Hyslop, Hákon Hákonarson, Walter A. Kukull, Lindsay A. Farrer, Lisa L. Barnes, Thomas G. Beach, F. Yesim Demirci, Elizabeth Head, Christine M. Hulette, Gregory A. Jicha, John S.K. Kauwe, Jonathan Kaye, James B. Leverenz, Allan I. Levey, Andrew P. Lieberman, V. Shane Pankratz, Wayne W. Poon, Joseph F. Quinn, Andrew J. Saykin, Lon S. Schneider, Amanda Smith, Joshua A. Sonnen, Robert A. Stern, Vivianna M. Van Deerlin, Linda J. Van Eldik, Denise Harold, Giancarlo Russo, David C. Rubinsztein, Antony Bayer, Magda Tsolaki, Petroula Proitsi, Nick C. Fox, Harald Hampel, Michael J. Owen, Simon Mead, Peter Passmore, Kevin Morgan, Markus M. Nöthen, Jonathan M. Schott, Martin N. Rossor, Michelle K. Lupton, Per Hoffmann, Johannes Kornhuber, Brian Lawlor, Andrew McQuillin, Ammar Al‐Chalabi, Joshua C. Bis, Agustı́n Ruiz, Merçé Boada, Sudha Seshadri, Alexa Beiser, Kenneth Rice, Sven J. van der Lee, Philip L. De Jager, Daniel H. Geschwind, Markus J. Riemenschneider, Steffi G. Riedel‐Heller, Jerome I. Rotter, Gerhard Ransmayr, Bradley T. Hyman, Carlos Cruchaga, Montserrat Alegret, Bendik S. Winsvold, Priit Palta, Kai-How Farh, Ester Cuenca-León, Nicholas A. Furlotte, Tobias Kurth, Lannie Ligthart, Gisela M. Terwindt, Tobias Freilinger, Caroline Ran, Scott D. Gordon, Guntram Borck, Hieab H.H. Adams, Terho Lehtimäki, Juho Wedenoja, Julie E. Buring, Markus Schürks, Maria Gudlaug Hrafnsdottir, Jouke‐Jan Hottenga, Brenda W.J.H. Penninx, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Nicholas G. Martin, Grant W. Montgomery, Mitja Kurki, Eija Hämäläinen, Hailiang Huang, Jie Huang, Cynthia Sandor, Caleb Webber, Bertram Müller‐Myhsok, Stefan Schreiber, Veikko Salomaa, Elizabeth Loehrer, Hartmut Göbel, Alfons Macaya, Patricia Pozo‐Rosich, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Andres Metspalu, Christian Kubisch, Michel D. Ferrari, Andrea Carmine Belin, Arn M. J. M. van den Maagdenberg, John‐Anker Zwart, Dorret I. Boomsma, Nicholas Eriksson, Jes Olesen, Daniel I. Chasman, Dale R. Nyholt, Richard Anney, Andreja Avberšek, Larry Baum, Samuel F. Berkovic, Jonathan P. Bradfield, Russell J. Buono, Claudia B. Catarino, Patrick Cossette, Peter De Jonghe, Chantal Depondt, Dennis Dlugos, Thomas N. Ferraro, Jacqueline A. French, Helle Hjalgrim, Jennifer Jamnadas-Khoda, Reetta Kälviäinen, Wolfram S. Kunz, Holger Lerche, Costin Leu, Dick Lindhout, Warren Lo, Daniel H. Lowenstein, Mark McCormack, Rikke S. Møller, Anne M. Molloy, Ping-Wing Ng, Karen Oliver, Michael Privitera, Rodney A. Radtke, Ann‐Kathrin Ruppert, Thomas Sander, Steven C. Schachter, Christoph J. Schankin, Ingrid E. Scheffer, Susanne Schoch, Sanjay M. Sisodiya, Phil E M Smith, Michael R. Sperling, Pasquale Striano, Rainer Surges, G. Neil Thomas, Frank Visscher, Christopher D. Whelan, Federico Zara, Erin L. Heinzen, Anthony G Marson, Felicitas Becker, Hans Stroink, Fritz Zimprich, Thomas Gasser, J. Raphael Gibbs, Peter Heutink, María Martínez, Huw R. Morris, Manu Sharma, Mina Ryten, Kin Y. Mok, Sara L. Pulit, Steve Bevan, Elizabeth G. Holliday, John Attia, Thomas W.K. Battey, Giorgio B. Boncoraglio, Vincent Thijs, Wei‐Min Chen, Braxton D. Mitchell, Peter M. Rothwell, Pankaj Sharma, Cathie Sudlow, Astrid M. Vicente, Hugh S. Markus, Christina Kourkoulis, Joanna Pera, Miriam R. Raffeld, Scott Silliman, Vesna Boraska Perica, Laura M. Thornton, Laura M. Huckins, N. William Rayner, Cathryn M. Lewis, Mónica Gratacòs, Filip Rybakowski, Anna Keski‐Rahkonen, Anu Raevuori, James I. Hudson, Ted Reichborn‐Kjennerud, Palmiero Monteleone, Andreas Karwautz, Katrin Männik, Jessica H. Baker, Julie K. O’Toole, Sara E. Trace, Oliver S. P. Davis, Sietske G. Helder, Stefan Ehrlich, Beate Herpertz‐Dahlmann, Unna N. Danner, Annemarie Elburg, Maurizio Clementi, Monica Forzan, Elisa Docampo, Jolanta Lissowska, Joanna Hauser, Alfonso Tortorella, Mario Maj, Fragiskos Gonidakis, Konstantinos Tziouvas, Hana Papežová, Zeynep Yılmaz, Gudrun Wagner, Sarah Cohen‐Woods, Stefan Herms, Antonio Julià, Raquel Rabionet, Danielle M. Dick, Samuli Ripatti, Ole A. Andreassen, Thomas Espeseth, Astri J. Lundervold, Vidar M. Steen, Dalila Pinto, Stephen W. Scherer, H.N. Aschauer, Alexandra Schosser, Lars Alfredsson, Leonid Padyukov, Katherine A. Halmi, James E. Mitchell, Michael Strober, Andrew W. Bergen, Walter H. Kaye, Jin P. Szatkiewicz, Bru Cormand, Josep Antoni Ramos‐Quiroga, Cristina Sánchez‐Mora, Marta Ribasés, Miguel Casas, Amaia Hervás, María J. Arranz, Jan Haavik, Tetyana Zayats, Stefan Johansson, Nigel Williams, Josephine Elia, Astrid Dempfle, Aribert Rothenberger, Jonna Kuntsi, Robert D. Oades, Tobias Banaschewski,
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from ...
American Association for the Advancement of Science
Phil H. Lee, Verneri Anttila, Hyejung Won, Yen‐Chen Anne Feng, Jacob Rosenthal, Zhaozhong Zhu, Elliot M. Tucker‐Drob, Michel G. Nivard, Andrew D. Grotzinger, Daniëlle Posthuma, Meg M.-J. Wang, Dongmei Yu, Eli A. Stahl, Raymond K. Walters, Richard Anney, Laramie E. Duncan, Tian Ge, Rolf Adolfsson, Tobias Banaschewski, Síntia Belangero, Edwin H. Cook, Giovanni Coppola, Eske M. Derks, Pieter J. Hoekstra, Jaakko Kaprio, Anna Keski‐Rahkonen, George Kirov, Henry R. Kranzler, Jurjen J. Luykx, Luís Augusto Rohde, Clement C. Zai, Esben Agerbo, María J. Arranz, Philip Asherson, Marie Bækvad‐Hansen, Gísli Baldursson, Mark A. Bellgrove, Richard A. Belliveau, Jan K. Buitelaar, Christie L. Burton, Jonas Bybjerg‐Grauholm, Miguel Casas, Felecia Cerrato, Kimberly Chambert, Tracy Air, Bru Cormand, Jennifer Crosbie, Søren Dalsgaard, Ditte Demontis, Alysa E. Doyle, Ashley Dumont, Josephine Elia, Jakob Grove, Ólafur Ó. Guðmundsson, Jan Haavik, Hákon Hákonarson, Christine Søholm Hansen, Catharina A. Hartman, Ziarih Hawi, Amaia Hervás, David M. Hougaard, Daniel P. Howrigan, Hailiang Huang, Jonna Kuntsi, K. Langley, Klaus‐Peter Lesch, Patrick W. L. Leung, Sandra K. Loo, Joanna Martin, Alicia R. Martin, James J. McGough, Sarah E. Medland, Jennifer L. Moran, Ole Mors, Preben Bo Mortensen, Robert D. Oades, Duncan S. Palmer, Carsten Bøcker Pedersen, Marianne G. Pedersen, Triinu Peters, Timothy Poterba, Jesper Buchhave Poulsen, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Aribert Rothenberger, Paula Rovira, Cristina Sánchez‐Mora, F. Kyle Satterstrom, Russell Schachar, María Soler Artigas, Stacy Steinberg, Hreinn Stefánsson, Patrick Turley, G. Bragi Walters, Thomas Werge, Tetyana Zayats, Dan E. Arking, Francesco Bettella, Joseph D. Buxbaum, Jane Christensen, Ryan L. Collins, Hilary Coon, Silvia De Rubeis, Richard Delorme, Dorothy E. Grice, Thomas Hansen, Peter Holmans, Sigrun Hope, Christina M. Hultman, Lambertus Klei, Christine Ladd‐Acosta, Páll Magnússon, Terje Nærland, Mette Nyegaard, Dalila Pinto, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer Reichert, Kathryn Roeder, Guy A. Rouleau, Evald Sæmundsen, Stephan Sanders, Sven Sandin, Beaté St Pourcain, Kāri Stefánsson, James S. Sutcliffe, Michael E. Talkowski, Lauren A. Weiss, A. Jeremy Willsey, Ingrid Agartz, Huda Akil, Diego Albani, Martin Alda, Thomas D. Als, Adebayo Anjorin, Lena Backlund, Nicholas Bass, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Sarah E. Bergen, Wade H. Berrettini, Joanna M. Biernacka, Douglas Blackwood, Erlend Bøen, Monika Budde, William E. Bunney, Margit Burmeister, William Byerley, Enda M. Byrne, Sven Cichon, Toni‐Kim Clarke, Jonathan R. I. Coleman, Nicholas Craddock, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Torbjørn Elvsåshagen, Bruno Étain, Sascha B. Fischer, Andreas J. Forstner, Liz Forty, Josef Frank, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Héléna A. Gaspar, Elliot S. Gershon, Michael Gill, Fernando S. Goes, Scott D. Gordon, Katherine Gordon‐Smith, Melissa J. Green, Tiffany A. Greenwood, Maria Grigoroiu‐Serbânescu, José Guzmán‐Parra, Joanna Hauser, Martin Hautzinger, Urs Heilbronner, Stefan Herms, Per Hoffmann, Dominic Holland, Stéphane Jamain, Ian Jones, Lisa Jones, Radhika Kandaswamy, John R. Kelsoe, James L. Kennedy, Oedegaard Ketil Joachim, Sarah Kittel‐Schneider, Manolis Kogevinas, Anna C. Koller, Catharina Lavebratt, Cathryn M. Lewis, Qingqin S. Li, Jolanta Lissowska, Loes M. Olde Loohuis, Susanne Lucae, Anna Maaser, Ulrik Fredrik Malt, Nicholas G. Martin, Lina Martinsson, Susan L. McElroy, Francis J. McMahon, Andrew McQuillin, Ingrid Melle, Andres Metspalu, Vincent Millischer, Philip B. Mitchell, Grant W. Montgomery, Gunnar Morken, Derek W. Morris, Bertram Müller‐Myhsok, Niamh Mullins, R Myers, Caroline M. Nievergelt, Merete Nordentoft, Annelie Nordin Adolfsson, Markus M. Nöthen, Roel A. Ophoff, Michael J. Owen, Sara A. Paciga, Carlos N. Pato, Michele T. Pato, Roy H. Perlis, Amy Perry, James B. Potash, Céline S. Reinbold, Marcella Rietschel, Margarita Rivera, Mary Roberson, Martin Schalling, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Engilbert Sigurðsson, Olav B. Smeland, Eystein Stordal, Fabian Streit, Jana Strohmaier, Thorgeir E. Thorgeirsson, Jens Treutlein, Gustavo Turecki, Arne E. Vaaler, Eduard Vieta, John B. Vincent, Yunpeng Wang, Stephanie H. Witt, Peter P. Zandi, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, H.N. Aschauer, Jessica H. Baker, Vladimír Bencko, Andrew W. Bergen, Andreas Birgegård, Vesna Boraska Perica, Harry Brandt, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Philippe Courtet, Steven Crawford, Scott J. Crow, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Elisa Docampo, Karin Egberts, Stefan Ehrlich, Thomas Espeseth, Fernando Fernández‐Aranda, Manfred M. Fichter, Lenka Foretová, Monica Forzan, Giovanni Gambaro, Ina Giegling, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Yiran Guo, Katherine A. Halmi, Konstantinos Hatzikotoulas,
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic ...
Cell Press
Gabriëlla A.M. Blokland, Jakob Grove, Chia‐Yen Chen, Chris Cotsapas, Stuart A. Tobet, Robert J. Handa, David St Clair, Todd Lencz, Bryan Mowry, Sathish Periyasamy, Murray J. Cairns, Paul A. Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick F. Sullivan, Aiden Corvin, Brien P. Riley, Tõnu Esko, Lili Milani, Erik G. Jönsson, Aarno Palotie, Hannelore Ehrenreich, Martin Begemann, Agnes Steixner-Kumar, Pak C. Sham, Nakao Iwata, Daniel R. Weinberger, Pablo V. Gejman, Alan R. Sanders, Joseph D. Buxbaum, Dan Rujescu, Ina Giegling, Bettina Konte, Annette M. Hartmann, Elvira Bramon, Robin M. Murray, Michele T. Pato, Jimmy Lee, Ingrid Melle, Espen Molden, Roel A. Ophoff, Andrew McQuillin, Nicholas Bass, Rolf Adolfsson, Anil K. Malhotra, Nicholas G. Martin, Janice M. Fullerton, Philip B. Mitchell, Peter R. Schofield, Andreas J. Forstner, Franziska Degenhardt, Sabrina K. Schaupp, Ashley L. Comes, Manolis Kogevinas, José Guzmán‐Parra, Andreas Reif, Fabian Streit, Lea Sirignano, Sven Cichon, Maria Grigoroiu‐Serbânescu, Joanna Hauser, Jolanta Lissowska, Fermín Mayoral, Bertram Müller‐Myhsok, Beata Świątkowska, Thomas G. Schulze, Markus M. Nöthen, Marcella Rietschel, John R. Kelsoe, Marion Leboyer, Stéphane Jamain, Bruno Étain, Frank Bellivier, John B. Vincent, Martin Alda, Claire O’Donovan, Pablo Cervantes, Joanna M. Biernacka, Mark A. Frye, Susan L. McElroy, Laura J. Scott, Eli A. Stahl, Mikael Landén, Marian L. Hamshere, Olav B. Smeland, Srdjan Djurovic, Arne E. Vaaler, Ole A. Andreassen, Bernhard T. Baune, Tracy Air, Martin Preisig, Rudolf Uher, Douglas F. Levinson, Myrna M. Weissman, James B. Potash, Jianxin Shi, James A. Knowles, Roy H. Perlis, Susanne Lucae, Dorret I. Boomsma, Brenda W.J.H. Penninx, Jouke‐Jan Hottenga, Eco J. C. de Geus, Gonneke Willemsen, Yuri Milaneschi, Henning Tiemeier, Hans J. Grabe, Alexander Teumer, Sandra Van der Auwera, Uwe Völker, Steven P. Hamilton, Patrik K. E. Magnusson, Alexander Viktorin, Divya Mehta, Niamh Mullins, Mark J. Adams, Gerome Breen, Andrew M. McIntosh, Cathryn M. Lewis, David M. Hougaard, Merete Nordentoft, Ole Mors, Preben Bo Mortensen, Thomas Werge, Thomas D. Als, Anders D. Børglum, Tracey L. Petryshen, Jordan W. Smoller, Jill M. Goldstein, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James Walters, Kai-How Farh, Peter Holmans, Phil Lee, Brendan Bulik‐Sullivan, David Collier, Hailiang Huang, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu‐Alin Bacanu, Martin Begemann, Richard A. Belliveau, Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberly D. Chambert, Raymond C. K. Chan, Ronald Y.L. Chen, Eric Chen, Wei Cheng, Eric F.C. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del‐Favero, Ditte Demontis, Dimitris Dikeos, Timothy G. Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan G. Eriksson, Valentina Escott‐Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti‐Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, В. Е. Голимбет, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Marian L. Hamshere, Thomas Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Jānis Kloviņš, James A. Knowles, Bettina Konte, Vaidutis Kučinskas, Zita Aušrelė Kučinskienė, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee, Sang Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung‐Yee Liang, Jeffrey A. Lieberman, Limborskaia Sa, Carmel M. Loughland, Jan Lubiński, Jouko Lönnqvist, Milan Maçek, Patrik K. E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Béla Melegh, Ingrid Melle, Raquelle I. Mesholam‐Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin‐Germeys, Bertram Müller‐Myhsok, Mari Nelis, Igor Nenadić, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Ņikitina-Zaķe, Laura Nisenbaum, Annelie Nordin, Eadbhard O’Callaghan,
Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls ...
Elsevier BV
Niamh Mullins, Jooeun Kang, Adrián I. Campos, Jonathan R. I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey A. Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark J. Adams, Swapnil Awasthi, Michael J. Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi‐Chung Chen, Steven Crawford, Scott J. Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández‐Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai‐Gwo Hwu, Sonia Jain, Stéphane Jamain, Susana Jiménez‐Múrcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly Klump, Dong Li, Shih‐Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih‐Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolás Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yılmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M.H. Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Peter Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David Braff, Richard A. Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas John Craddock, David W. Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Justine M. Gatt, Pablo V. Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Maria Grigoroiu‐Serbânescu, Blanca Gutiérrez, José Guzmán‐Parra, Steven P. Hamilton, Marian L. Hamshere, Annette M. Hartmann, Joanna Hauser, Stefanie Heilmann‐Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa Jones, Lina Jönsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie‐Odile Krebs, Mikael Landén, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermín Mayoral, Susan L. McElroy, Patrick J. McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Müller-Myhsok, Caroline M. Nievergelt, Vishwajit L. Nimgaonkar, Markus M. Nöthen, Michael O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos N. Pato, Michele T. Pato, Brenda W.J.H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea L. Roberts, Gloria Roberts, Guy A. Rouleau, Diego Luiz Rovaris, Dan Rujescu, Cristina Sánchez‐Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley I. Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund Sonuga‐Barke, Gianfranco Spalletta, John S. Strauss, Beata Świątkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar‐Ribó, John B. Vincent, Henry Völzke, James Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley‐Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin H. McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Børglum, Gerome Breen, Annette Erlangsen, Tõnu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David J. Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po‐Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Rentería, Daniel J. Smıth, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia L. Willour, Douglas M. Ruderfer, Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M. Byrne, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy Air, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, Tim B. Bigdeli, Elisabeth B. Binder, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, Na Cai, Enrique Castelao, Jane Christensen, Toni‐Kim Clarke, Jonathan R. I. Coleman, Lucía Colodro‐Conde, Baptiste Couvy‐Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Franziska Degenhardt, Eske M. Derks,
Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders.
Elsevier BV
Jan Gnus, A. Czerski, Jolanta Bujok, Stanisław Ferenc, Wojciech Zawadzki, Wojciech Witkiewicz, Willy Hauzer, Agnieszka Rusiecka, Maciej Janeczek,
The study was conducted on 30 New Zealand rabbits weighing 3-4 kg from which sample strips of the abdominal aorta were collected. The study investigated the in vitro reaction of rabbit aorta smooth muscle to ligands binding to beta-adrenergic receptors. The response of aortic strips to beta-adrenergic receptor agonists (dobutamine, isoproterenol, salbutamol) and the influence of beta-adrenergic receptor antagonists (propranolol, betaxolol) on contractile activity was determined. All tested agonists ...
Tópico(s): Receptor Mechanisms and Signaling
2013 - Institute of Systematics and Evolution of Animals, Polish Academy of Sciences | Folia Biologica
Wojciech Witkiewicz, Wojciech Zawadzki, Jan Gnus, A. Czerski, Maciej Janeczek, Willy Hauzer, Kornel Ratajczak, Agnieszka Rusiecka,
Tópico(s): Xenotransplantation and immune response
2013 - Wydawnictwo Przegląd Lekarski | Przegląd Lekarski
M. Rietschel, Manuel Mattheisen, F. Degenhardt, René S. Kahn, Don Linszen, Jim van Os, Durk Wiersma, Richard Bruggeman, Wiepke Cahn, Lieuwe de Haan, Lydia Krabbendam, Inez Myin‐Germeys, Thomas W. Mühleisen, Peter Kirsch, Christine Esslinger, Stefan Herms, Ditte Demontis, Michael Steffens, J Strohmaier, Britta Haenisch, René Breuer, Piotr M. Czerski, I Giegling, E Strengman, C Schmael, Ole Mors, Preben Bo Mortensen, D M Hougaard, Torben Ørntoft, Paweł Kapelski, Lutz Priebe, F B Basmanav, Andreas J. Forstner, Per Hoffmann, S Meier, J A. Nikitopoulos, Susanne Moebus, Michael P. Alexander, R Mössner, H-E Wichmann, S. Schreiber, Fernando Rivandeneira, A. Hofman, André G. Uitterlinden, T. F. Wienker, J Schumacher, J Hauser, W. Maier, R. M. Cantor, Susanne Erk, Thomas G. Schulze, Hreinn Stefánsson, Stacy Steinberg, Ómar Gústafsson, Engilbert Sigurðsson, Hannes Pétursson, Augustine Kong, Kári Stéfansson, Olli Pietiläinen, Annamari Tuulio‐Henriksson, Tiina Paunio, Jouko Lönnqvist, Jaana Suvisaari, Leena Peltonen, Mirella Ruggeri, Sarah Tosato, Muriel Walshe, Robin M. Murray, David Collier, David St Clair, Thomas Hansen, Andrés Ingason, Klaus D. Jakobsen, Linh Viet Duong, Thomas Werge, Ingrid Melle, Ole A. Andreassen, Srdjan Djurovic, István Bitter, János Réthelyi, Л. И. Абрамова, В. Г. Каледа, В. Е. Голимбет, Erik G. Jönsson, Lars Terenius, Ingrid Agartz, Ruud van Winkel, Günter Kenis, Marc D. Binder, Jan H. Veldink, Carsten Wiuf, Michael Didriksen, Nick Craddock, Michael J. Owen, Michael O’Donovan, Anders D. Børglum, Dan Rujescu, Henrik Walter, Andreas Meyer‐Lindenberg, Markus M. Nöthen, Roel A. Ophoff, Sven Cichon,
Recent molecular studies have implicated common alleles of small to moderate effect and rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is expected that the reliable detection of risk variants with very small effect sizes can only be achieved through the recruitment of very large samples of patients and controls (that is tens of thousands), or large, potentially more homogeneous samples that have been recruited from confined geographical areas using identical ...
Tópico(s): Genomics and Rare Diseases
2011 - Springer Nature | Molecular Psychiatry
Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos Santoro, Vanessa Kiyomi Ota, Cristiano Noto, Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M. Byrne, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy Air, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, Tim B. Bigdeli, Elisabeth B. Binder, Douglas Blackwood, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, Na Cai, Enrique Castelao, Jane Christensen, Toni‐Kim Clarke, Jonathan R. I. Coleman, Lucía Colodro‐Conde, Baptiste Couvy‐Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Ian J. Deary, Franziska Degenhardt, Eske M. Derks, Neşe Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott‐Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Andreas J. Forstner, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Jakob Grove, Christine Søholm Hansen, Thomas Hansen, Stefan Herms, Ian B. Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke‐Jan Hottenga, David M. Hougaard, Marcus Ising, Philip R. Jansen, Ian Jones, Lisa Jones, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Jesper Krogh, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick J. McGrath, Peter McGuffin, Sarah E. Medland, Divya Mehta, Christel M. Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Högni Óskarsson, Michael J. Owen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Erik Pettersson, Wouter J. Peyrot, Giorgio Pistis, Daniëlle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Margarita Rivera, Saira Saeed Mirza, Robert A. Schoevers, Eva C. Schulte, Ling Shen, Stanley I. Shyn, Engilbert Sigurðsson, Grant Sinnamon, Johannes H. Smit, Daniel J. Smıth, Hreinn Stefánsson, Stacy Steinberg, Fabian Streit, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley K. Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Shantel Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H. Witt, Yang Wu, Hualin Simon Xi, Jian Yang, Futao Zhang, Volker Arolt, Bernhard T. Baune, Kenneth I. Berger, Dorret I. Boomsma, Sven Cichon, Udo Dannlowski, Eco J. C. de Geus, J. Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tõnu Esko, Hans J. Grabe, Steven P. Hamilton, Caroline Hayward, Andrew C. Heath, Kenneth S. Kendler, Stefan Kloiber, Glyn Lewis, Qingqin S. Li, Susanne Lucae, Pamela A. F. Madden, Patrik K. E. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller‐Myhsok, Merete Nordentoft, Markus M. Nöthen, Michael O’Donovan, Sara A. Paciga, Nancy L. Pedersen, Brenda W.J.H. Penninx, Roy H. Perlis, David J. Porteous, James B. Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas G. Schulze, Jordan W. Smoller, Hreinn Stefánsson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna M. Weissman, Thomas Werge, Cathryn M. Lewis, Douglas F. Levinson, Anders D. Børglum, Patrick F. Sullivan, Sandra Meier, John S. Strauss, Wei Xu, John B. Vincent, K. Matthews, Manuel A. R. Ferreira, Colm O’Dushlaine, Shaun Purcell, Soumya Raychaudhuri, Douglas M. Ruderfer, Pamela Sklar, Laura J. Scott, Matthew Flickinger, Margit Burmeister, Jun Z. Li, Weihua Guan, Devin Absher, Robert C. Thompson, Fan Guo Meng, Alan F. Schatzberg, William E. Bunney, Jack D. Barchas, Stanley J. Watson, R Myers, Huda Akil, Michael Boehnke, Kimberly Chambert, Jennifer L. Moran, Edward M. Scolnick, Srdjan Djurovic, Ingrid Melle, Gunnar Morken, Aiden Corvin, Adebayo Anjorin, Radhika Kandaswamy, Jacob Lawrence, Alan McLean, Ben Pickard, Sarah E. Bergen, Vishwajit L. Nimgaonkar, Mikael Landén, Martin Schalling, Urban Ösby, Lena Backlund, Louise Frisén, Niklas Långström, Eli Stahl, Amanda Dobbyn, Stéphane Jamain, Bruno Étain, Frank Bellivier, Markus Leber, Anna Maaser, Sascha B. Fischer, Céline S. Reinbold, Sarah Kittel‐Schneider, Janice M. Fullerton, Lilijana Oruč, G. Para, Fermín Mayoral, Fabio Rivas, Piotr M. Czerski, Jutta Kammerer-Ciernioch, Helmut Vedder, Margitta Borrmann-Hassenbach, Andrea Pfennig, Paul Brennan, James McKay, Manolis Kogevinas, Markus Schwarz, Peter R. Schofield, Thomas W. Mühleisen, Johannes Schumacher, Michael Bauer, A. Jordan Wright, Philip B. Mitchell, Martin Hautzinger, John R. Kelsoe, Tiffany A. Greenwood, Caroline M. Nievergelt, Paul D. Shilling, Erin N. Smith, Cinnamon S. Bloss, Howard J. Edenberg, Daniel L. Koller, Elliot S. Gershon, Chunyu Liu, Judith A. Badner, William A. Scheftner, William Lawson, Evaristus A. Nwulia, Maria Hipolito, William Coryell, John P. Rice,
Abstract Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree ( n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying ...
Nature Portfolio
Douglas M. Ruderfer, Stephan Ripke, Andrew McQuillin, James Boocock, Eli A. Stahl, Jennifer M. Whitehead Pavlides, Niamh Mullins, Alexander W. Charney, Anil P. S. Ori, Loes M. Olde Loohuis, Enrico Domenici, Arianna Di Florio, Sergi Papiol, János Kálmán, Vassily Trubetskoy, Rolf Adolfsson, Ingrid Agartz, Esben Agerbo, Huda Akil, Diego Albani, Margot Albus, Martin Alda, Madeline Alexander, Ney Alliey‐Rodriguez, Thomas D. Als, Farooq Amin, Adebayo Anjorin, María J. Arranz, Swapnil Awasthi, Silviu‐Alin Bacanu, Judith A. Badner, Marie Bækvad‐Hansen, Steven C. Bakker, Gavin Band, Jack D. Barchas, Inês Barroso, Nicholas Bass, Michael Bauer, Bernhard T. Baune, Martin Begemann, Céline Bellenguez, Richard A. Belliveau, Frank Bellivier, Stephan Bender, Judit Bene, Sarah E. Bergen, Wade H. Berrettini, Elizabeth Bevilacqua, Joanna M. Biernacka, Tim B. Bigdeli, Donald W. Black, Hannah Blackburn, Jenefer M. Blackwell, Douglas Blackwood, Carsten Bøcker Pedersen, Michael Boehnke, Marco P. Boks, Anders D. Børglum, Elvira Bramon, Gerome Breen, Matthew A. Brown, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, Monika Budde, Brendan Bulik‐Sullivan, Suzannah J. Bumpstead, William E. Bunney, Margit Burmeister, Joseph D. Buxbaum, Jonas Bybjerg‐Grauholm, William Byerley, Wiepke Cahn, Guiqing Cai, Murray J. Cairns, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Juan P. Casas, Miguel Casas, Stanley V. Catts, Pablo Cervantes, Kimberley D. Chambert, Raymond C. K. Chan, Eric Chen, Ronald Y.L. Chen, Wei Cheng, Eric F.C. Cheung, Siow Ann Chong, Toni‐Kim Clarke, C. Robert Cloninger, David Cohen, Nadine Cohen, Jonathan R. I. Coleman, David Collier, Paul Cormican, William Coryell, Nicholas John Craddock, David W. Craig, Benedicto Crespo‐Facorro, James J. Crowley, Cristiana Cruceanu, David Curtis, Piotr M. Czerski, Anders M. Dale, Mark J. Daly, Udo Dannlowski, Ariel Darvasi, Michael Davidson, Kenneth L. Davis, Christiaan de Leeuw, Franziska Degenhardt, Jurgen Del‐Favero, Lynn E. DeLisi, Panos Deloukas, Ditte Demontis, J. Raymond DePaulo, Marta Di Forti, Dimitris Dikeos, Timothy G. Dinan, Srdjan Djurovic, Amanda Dobbyn, Peter Donnelly, Gary Donohoe, Elodie Drapeau, Serge Dronov, Jubao Duan, Frank Dudbridge, Audrey Duncanson, Howard J. Edenberg, Sarah Edkins, Hannelore Ehrenreich, Peter Eichhammer, Torbjørn Elvsåshagen, Johan G. Eriksson, Valentina Escott‐Price, Tõnu Esko, Laurent Essioux, Bruno Étain, Chun Chieh Fan, Kai-How Farh, Martilias S. Farrell, Matthew Flickinger, Tatiana Foroud, Liz Forty, Josef Frank, Lude Franke, Christine Fraser, Robert Freedman, Colin Freeman, Nelson B. Freimer, Joseph I. Friedman, Menachem Fromer, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Héléna A. Gaspar, Pablo V. Gejman, Giulio Genovese, Lyudmila Georgieva, Claudia Giambartolomei, Eleni Giannoulatou, Ina Giegling, Michael Gill, Matthew Gillman, Marianne Giørtz Pedersen, Paola Giusti‐Rodríguez, Stephanie Godard, Fernando S. Goes, Jacqueline I. Goldstein, Srihari Gopal, Scott D. Gordon, Katherine Gordon‐Smith, Jacob Gratten, Emma Gray, Elaine Green, Melissa J. Green, Tiffany A. Greenwood, Maria Grigoroiu‐Serbânescu, Jakob Grove, Weihua Guan, Hugh Gurling, José Guzmán‐Parra, Rhian Gwilliam, Lieuwe de Haan, Jérémy Hall, Mei‐Hua Hall, Christian Hammer, Naomi Hammond, Marian L. Hamshere, Thomas Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Joanna Hauser, Martin Hautzinger, Urs Heilbronner, Garrett Hellenthal, Frans A. Henskens, Stefan Herms, Maria Hipolito, Joel N. Hirschhorn, Per Hoffmann, Mads V. Hollegaard, David M. Hougaard, Hailiang Huang, Laura M. Huckins, Christina M. Hultman, Sarah Hunt, Masashi Ikeda, Nakao Iwata, Conrad Iyegbe, Assen Jablensky, Stéphane Jamain, Janusz Jankowski, Alagurevathi Jayakumar, Inge Joa, Ian Jones, Lisa Jones, Erik G. Jönsson, Antonio Julià, Anders Juréus, Anna K. Kähler, René S. Kahn, Luba Kalaydjieva, Radhika Kandaswamy, Sena Karachanak-Yankova, Juha Karjalainen, Robert Karlsson, David Kavanagh, Matthew C. Keller, Brian Kelly, John R. Kelsoe, James L. Kennedy, Andrey Khrunin, Yunjung Kim, George Kirov, Sarah Kittel‐Schneider, Jānis Kloviņš, Jo Knight, Sarah Knott, James A. Knowles, Manolis Kogevinas, Bettina Konte, Eugenia Kravariti, Vaidutis Kučinskas, Zita Aušrelė Kučinskienė, Ralph Kupka, Hana Kuzelova-Ptackova, Mikael Landén, Cordelia Langford, Claudine Laurent, Jacob Lawrence, Stephen M. Lawrie, William Lawson, Markus Leber, Marion Leboyer, Phil H. Lee, Jimmy Lee, Sophie E. Legge, Todd Lencz, Bernard Lerer, Douglas F. Levinson, Shawn Levy, Cathryn M. Lewis, Jun Z. Li, Miaoxin Li, Qingqin S. Li, Tao Li, Kung‐Yee Liang, Jennifer Liddle, Jeffrey A. Lieberman, Limborskaia Sa, Kuang Lin, Don Linszen, Jolanta Lissowska, Chunyu Liu, Jianjun Liu, Jouko Lönnqvist, Carmel M. Loughland, Jan Lubiński, Susanne Lucae, Milan Maçek, Donald J. MacIntyre, Patrik K. E. Magnusson, Brion S. Maher, Pamela B. Mahon, Wolfgang Maier, Anil K. Malhotra, Jacques Mallet, Ulrik Fredrik Malt, Hugh S. Markus, Sara Marsal, Nicholas G. Martin,
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, ...
Cell Press
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola‐Ayele, Yi‐Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean‐Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant‐Petitjean, Pablo Cervantes, Hsi‐Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Étain, Stéphane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie Garnham, Fernando S. Goes, Maria Grigoroiu‐Serbânescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jiménez, Jean‐Pierre Kahn, Layla Kassem, Po‐Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel‐Schneider, Sebastian Kliwicki, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomáš Novák, Claire O’Donovan, Norio Ozaki, Urban Ösby, Andrea Pfennig, James B. Potash, Andreas Reif, Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M. Byrne, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy Air, Till F. M. Andlauer, Silviu‐Alin Bacanu, Marie Bækvad‐Hansen, Aartjan T.F. Beekman, Tim B. Bigdeli, Elisabeth B. Binder, Douglas Blackwood, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg‐Grauholm, Na Cai, Enrique Castelao, Jane Christensen, Toni‐Kim Clarke, Jonathan R. I. Coleman, Lucía Colodro‐Conde, Baptiste Couvy‐Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Ian J. Deary, Franziska Degenhardt, Eske M. Derks, Neşe Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott‐Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Andreas J. Forstner, Josef Frank, Helena Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Jakob Grove, Lynsey S. Hall, Christine Søholm Hansen, Thomas Hansen, Stefan Herms, Ian B. Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke‐Jan Hottenga, David M. Hougaard, Marcus Ising, Rick Jansen, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Jesper Krogh, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick J. McGrath, Peter McGuffin, Sarah E. Medland, Divya Mehta, Christel M. Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Högni Óskarsson, Michael J. Owen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Erik Pettersson, Wouter J. Peyrot, Giorgio Pistis, Daniëlle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Margarita Rivera, Saira Saeed Mirza, Robert A. Schoevers, Eva C. Schulte, Ling Shen, Jianxin Shi, Stanley I. Shyn, Engilbert Sigurðsson, Grant Sinnamon, Johannes H. Smit, Daniel J. Smıth, Hreinn Stefánsson, Stacy Steinberg, Fabian Streit, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Shantel Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H. Witt, Yang Wu, Hualin Simon Xi, Jian Yang, Futao Zhang, Volker Arolt, Bernhard T. Baune, Kenneth I. Berger, Dorret I. Boomsma, Sven Cichon, Udo Dannlowski, Eco J. C. de Geus, J. Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tõnu Esko, Hans J. Grabe, Steven P. Hamilton, Caroline Hayward, Andrew C. Heath, Kenneth S. Kendler, Stefan Kloiber, Glyn Lewis, Qingqin S. Li, Susanne Lucae, Pamela A. F. Madden, Patrik K. E. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller‐Myhsok, Merete Nordentoft, Markus M. Nöthen, Michael O’Donovan, Sara A. Paciga, Nancy L. Pedersen, Brenda W.J.H. Penninx, Roy H. Perlis, David J. Porteous, James B. Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas G. Schulze, Jordan W. Smoller, Hreinn Stefánsson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna M. Weissman, Thomas Werge, Cathryn M. Lewis, Douglas F. Levinson, Gerome Breen, Anders D. Børglum, Patrick F. Sullivan, Eva Z. Reininghaus, Guy A. Rouleau, Janusz Rybakowski, Martin Schalling, Peter R. Schofield, Barbara Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopková,
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained ...
Springer Nature