Kaare Harald Bønaa, Jan Mannsverk, Rune Wiseth, Lars Aaberge, Yngvar Myreng, Ottar Nygård, Dennis W Nilsen, Nils‐Einar Kløw, Michael Uchto, Thor Trovik, Bjørn Bendz, Sindre Stavnes, Reidar Bjørnerheim, Alf-Inge Larsen, Morten Slette, Terje K. Steigen, Ole Johan Jakobsen, Øyvind Bleie, Eigil Fossum, Tove Aminda Hanssen, Øystein Dahl-Eriksen, Inger Njølstad, Knut Rasmussen, Tom Wilsgaard, Jan Erik Nordrehaug,
Limited data are available on the long-term effects of contemporary drug-eluting stents versus contemporary bare-metal stents on rates of death, myocardial infarction, repeat revascularization, and stent thrombosis and on quality of life.We randomly assigned 9013 patients who had stable or unstable coronary artery disease to undergo percutaneous coronary intervention (PCI) with the implantation of either contemporary drug-eluting stents or bare-metal stents. In the group receiving drug-eluting stents, ...
Tópico(s): Cardiac Valve Diseases and Treatments
2016 - Massachusetts Medical Society | New England Journal of Medicine
Lars Daae Horvei, Gro Grimnes, Kristian Hindberg, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Brox, Sigrid K. Brækkan, John‐Bjarne Hansen,
Essentials•We performed repeated measurements of C‐reactive protein (CRP) and obesity in a cohort study.•CRP was associated with risk of myocardial infarction and venous thromboembolism.•CRP was a mediator for risk of myocardial infarction in obese men and women.•CRP was a partial mediator for risk of venous thromboembolism in obese women, but not in men.Summary: BackgroundLow‐grade inflammation in obesity may be a shared pathway for the risk of venous thromboembolism (VTE) and myocardial infarction ( ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2016 - Elsevier BV | Journal of Thrombosis and Haemostasis
Trygve S. Ellingsen, Tove Skjelbakken, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Brox, Sigrid K. Brækkan, John‐Bjarne Hansen, Jostein Lappegård,
Summary Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until ...
Tópico(s): Blood properties and coagulation
2015 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Astrid Buvik, Trine Strand Bergmo, Einar Bugge, Arvid Smaabrekke, Tom Wilsgaard, Jan Abel Olsen,
Background: Telemedicine consultations using real-time videoconferencing has the potential to improve access and quality of care, avoid patient travels, and reduce health care costs. Objective: The aim of this study was to examine the cost-effectiveness of an orthopedic videoconferencing service between the University Hospital of North Norway and a regional medical center in a remote community located 148 km away. Methods: An economic evaluation based on a randomized controlled trial of 389 patients ( ...
Tópico(s): Peripheral Artery Disease Management
2018 - JMIR Publications | Journal of Medical Internet Research
Ingrid Toft, Marit D. Solbu, Jens Kronborg, Ulla Dorte Mathisen, Bjørn O. Eriksen, Hilde M. Storhaug, Toralf Melsom, Maja‐Lisa Løchen, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Brox,
BackgroundGlomerular filtration rate 60 mL/min/1.73m2) and possibly a more sensitive marker for cardiovascular risk and all-cause mortality. We examined the association of cystatin C with cardiovascular morbidity and all-cause mortality in a prospective population-based study.
Tópico(s): Dialysis and Renal Disease Management
2011 - Oxford University Press | Nephrology Dialysis Transplantation
E.M. Hald, Sigrid K. Brækkan, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Brox, John‐Bjarne Hansen,
High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population.High-sensitivity C-reactive protein was measured in serum samples from 6,426 men and women, aged 25-84 ...
Tópico(s): Blood properties and coagulation
2011 - Ferrata Storti Foundation | Haematologica
Sigrid K. Brækkan, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Störmer, John‐Bjarne Hansen,
See also Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk? This issue, pp 146–7. Summary. Background: Platelet size, measured as mean platelet volume (MPV), is associated with platelet reactivity. MPV is increased in acute myocardial infarction, and has been identified as an independent risk factor for future myocardial infarction and stroke. Objectives: The purpose of the study was to determine the impact of platelet count and MPV on the incidence of venous ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2009 - Elsevier BV | Journal of Thrombosis and Haemostasis
Knut H. Borch, Sigrid K. Brækkan, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Störmer, John‐Bjarne Hansen,
The purpose of this study was to assess the impact of various obesity measures on identification of subjects at risk and their respective risk estimates for VTE in a prospective population-based study.Measures of body composition such as body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR) were registered in 6708 subjects aged 25 to 84 years, who participated in the Tromsø Study (1994-1995). Incident VTE-events were registered during follow-up until September ...
Tópico(s): Health Promotion and Cardiovascular Prevention
2009 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Sigrid K. Brækkan, Ellisiv B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Störmer, J.-B. Hansen,
Recent studies indicate that arterial cardiovascular diseases and venous thromboembolism (VTE) share common risk factors. A family history of myocardial infarction (MI) is a strong and independent risk factor for future MI.The purpose of the present study was to determine the impact of cardiovascular risk factors, including family history of MI, on the incidence of VTE in a prospective, population-based study.Traditional cardiovascular risk factors and family history of MI were registered in 21,330 ...
Tópico(s): Acute Myocardial Infarction Research
2008 - Elsevier BV | Journal of Thrombosis and Haemostasis
Knut H. Borch, Sigrid K. Brækkan, E. B. Mathiesen, Inger Njølstad, Tom Wilsgaard, Jan Störmer, J.‐B. HANSEN,
The metabolic syndrome is a cluster of cardiovascular risk factors, including abdominal obesity, hypertension, dyslipidemia and insulin resistance, associated with increased risk of cardiovascular diseases and all cause mortality.The purpose of the study was to assess the impact of the metabolic syndrome, and its individual components, on the risk of venous thromboembolism (VTE) in a prospective population-based study.Individual components of the metabolic syndrome were registered in 6170 subjects ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2008 - Elsevier BV | Journal of Thrombosis and Haemostasis
Laila Arnesdatter Hopstock, Tom Wilsgaard, Inger Njølstad, Jan Mannsverk, Ellisiv B. Mathiesen, Maja‐Lisa Løchen, Kaare Harald Bønaa,
A seasonal pattern with higher winter morbidity and mortality has been reported for acute myocardial infarction (MI). The magnitude of the difference between peak and nadir season has been associated with latitude, but results are inconsistent. Studies of seasonal variation of MI in population-based cohorts, based on adjudicated MI cases,are few.We investigated the monthly and seasonal variation in first-ever nonfatal and fatal MI in the population of Tromsø in northern Norway, a region with a harsh ...
Tópico(s): Health disparities and outcomes
2010 - SAGE Publishing | European Journal of Cardiovascular Prevention & Rehabilitation
Ganesh Acharya, Tom Wilsgaard, Gro Berntsen, Jan Martin Maltau, Torvid Kiserud,
The purpose of this study was to construct new reference ranges for serial measurements of commonly used umbilical artery Doppler indices (pulsatility index, resistance index, and systolic:diastolic ratio).This was a prospective longitudinal study of the umbilical artery Doppler indices that were obtained serially at the free-loop of umbilical cord at 4-week intervals at 19 to 42 weeks of gestation in 130 low-risk singleton pregnancies. A total of 513 observations were used to construct the reference ...
Tópico(s): Birth, Development, and Health
2005 - Elsevier BV | American Journal of Obstetrics and Gynecology
Ganesh Acharya, Tom Wilsgaard, Gro Berntsen, Jan Martin Maltau, Torvid Kiserud,
Abstract Objective To construct reference ranges for serial measurements of umbilical artery (UA) blood flow velocity and pulsatility index (PI) at standardized insonation sites during the second half of pregnancy. Methods This was a prospective longitudinal study of the umbilical circulation. UA blood flow velocities were measured at the intra‐abdominal portion, fetal end and placental end at 4‐weekly intervals at 19–42 weeks of gestation in 130 low‐risk singleton pregnancies. A total of 513 observations ...
Tópico(s): Gestational Diabetes Research and Management
2005 - Wiley | Ultrasound in Obstetrics and Gynecology
Ganesh Acharya, Tom Wilsgaard, Gro Berntsen, Jan Martin Maltau, Torvid Kiserud,
To construct reference ranges for serial measurements of the umbilical artery (UA) absolute blood flow velocities in the second half of pregnancy and to test the hypothesis that significant associations exist between UA velocities and placental volume blood flow assessed from umbilical vein blood flow velocities and diameter.This was a prospective longitudinal study of the umbilical circulation. UA absolute velocities and umbilical vein blood flow were measured at 4-weekly intervals between 19 and ...
Tópico(s): Prenatal Screening and Diagnostics
2005 - Wiley | Ultrasound in Obstetrics and Gynecology
Ganesh Acharya, Tom Wilsgaard, Gro Berntsen, Jan Martin Maltau, Torvid Kiserud,
Objectives To construct new reference ranges for serial measurements of umbilical vein (UV) blood flow. Methods Prospective longitudinal study of blood flow velocities and diameter of the UV measured at four-weekly intervals during 19 to 42 weeks' gestation in 130 low-risk singleton pregnancies. Regression models and multilevel modeling were used to construct the reference ranges. Results On the basis of 511 sets of longitudinal observations, we established new reference percentiles of UV diameter, ...
Tópico(s): Gestational Diabetes Research and Management
2005 - Wiley | Prenatal Diagnosis
Line V. Hjelle, Per Ole M. Gundersen, Ragnhild Hellesnes, Mette Sprauten, Marianne Brydøy, Torgrim Tandstad, Tom Wilsgaard, Sophie D. Fosså, Jan Oldenburg, Roy M. Bremnes, Hege Sagstuen Haugnes,
Background: The long-term toxicities after cisplatin-based chemotherapy (CBCT) reveal a remarkable inter-individual variation among testicular cancer survivors (TCSs). Therefore, we assessed long-term platinum (Pt) changes and their associations with CBCT-related late effects in TCSs.Material and methods: In 77 TCSs treated with CBCT from 1984 to 1990, blood samples for analyses of Pt and a questionnaire including self-reported neuro- and ototoxicity (NTX) symptoms were collected during two follow-up ...
Tópico(s): Glioma Diagnosis and Treatment
2018 - Taylor & Francis | Acta Oncologica
Line V. Hjelle, Roy M. Bremnes, Per Ole M. Gundersen, Mette Sprauten, Marianne Brydøy, Torgrim Tandstad, Tom Wilsgaard, Sophie D. Fosså, Jan Oldenburg, Hege Sagstuen Haugnes,
To evaluate the associations between long-term serum levels of platinum (se-Pt) and neurotoxicity and ototoxicity (NTX), endocrine gonadal function (endocrine-GF), and cardiovascular disease (CVD) in testicular cancer survivors.A total of 292 cisplatin-treated testicular cancer survivors (1980-1994) participated in a national follow-up study (2007-2008). Se-Pt was quantified by inductively coupled plasma mass spectrometry, and categorized in quartiles. Symptoms of NTX were assessed with scale for chemotherapy- ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2016 - Elsevier BV | Urologic Oncology Seminars and Original Investigations
Geirmund Myklebust, Tom Wilsgaard, Bjarne K. Jacobsen, Jan Tore Gran,
Objective: To determine causes of death in patients with pure polymyalgia rheumatica (PMR) compared to matched population controls.Methods: In a population based study from 1987–1997, 315 patients were diagnosed with PMR. The patients were each randomly assigned four population controls, totally 1260 controls. The date and causes of death were identified from the data files at Statistics Norway up to the end of 1997.Results: A total of 65 cases (20.6%) with PMR died compared to 338 (26.8%) among the ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2003 - Taylor & Francis | Scandinavian Journal of Rheumatology
Ganesh Acharya, Tom Wilsgaard, Gro Berntsen, Jan Martin Maltau, Torvid Kiserud,
It has been suggested that constriction of the umbilical vein (UV) at the umbilical ring has hemodynamic effects. We aimed to determine the occurrence and extent of such constriction in serial observations.This was a prospective longitudinal study of UV velocities at the umbilicus measured at approximately 4-week intervals between 19 and 42 weeks' gestation in 129 low-risk singleton pregnancies. Each participant was examined three to five times. Multilevel modeling was used to construct the reference ...
Tópico(s): Maternal and fetal healthcare
2006 - Wiley | Ultrasound in Obstetrics and Gynecology
Jan Mannsverk, Tom Wilsgaard, Ellisiv B. Mathiesen, Maja‐Lisa Løchen, Knut Rasmussen, Dag S. Thelle, Inger Njølstad, Laila Arnesdatter Hopstock, Kaare Harald Bønaa,
Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors.We identified 29 582 healthy men and women ≥25 years of age who participated in 3 population surveys conducted between 1994 and 2008 in Tromsø, Norway. Age- and sex-adjusted incidence rates were calculated for coronary heart disease overall, out-of-hospital sudden death, and hospitalized ST-segment-elevation and ...
Tópico(s): Health Promotion and Cardiovascular Prevention
2015 - Lippincott Williams & Wilkins | Circulation
Bente Morseth, Luai A. Ahmed, Åshild Bjørnerem, Nina Emaus, Bjarne K. Jacobsen, Ragnar M. Joakimsen, Jan Störmer, Tom Wilsgaard, Lone Jørgensen,
Our aim was to examine associations between leisure time physical activity and risk of non-vertebral fractures in men and women aged ≥55 years, with focus on the anatomical fracture location. Self-reported physical activity was registered in 3,450 men and 4,072 women aged 55-97 years at baseline in the Tromsø Study, Norway, in 1994-1995. Non-vertebral fractures were registered through December 31, 2009. During 75,546 person-years at risk, 1,693 non-vertebral fractures were identified. Risk of any ...
Tópico(s): Pelvic and Acetabular Injuries
2012 - Springer Science+Business Media | European Journal of Epidemiology
Jan Mannsverk, Tom Wilsgaard, Inger Njølstad, Laila Arnesdatter Hopstock, Maja‐Lisa Løchen, Ellisiv B. Mathiesen, Dag S. Thelle, Knut Rasmussen, Kaare Harald Bønaa,
Although the mortality of coronary heart disease (CHD) has declined in Western countries during the last decades, studies have suggested that the prevention and treatment of CHD may not have been as effective in women as in men. We examined gender- and age-specific trends in incidence, case fatality and the severity of first myocardial infarction (MI) in a large Norwegian population-based study.Prospective population-based cohort study.A total of 31,323 participants enrolled between 1974 and 2001 ...
Tópico(s): Chronic Disease Management Strategies
2011 - Oxford University Press | European Journal of Preventive Cardiology
Anders Vik, Ellisiv B. Mathiesen, Jan Brox, Tom Wilsgaard, Inger Njølstad, Lone Jørgensen, J.‐B. HANSEN,
Osteoprotegerin (OPG) concentration in serum is associated with the presence and severity of atherosclerosis.To investigate the association between serum osteoprotegerin and the risk of a future myocardial infarction, ischemic stroke and mortality in a general population.OPG was measured in serum collected from 6265 subjects recruited from a general population without a prior myocardial infarction and ischemic stroke (the Tromsø Study). Incident myocardial infarction, ischemic stroke and mortality ...
Tópico(s): Bone health and treatments
2011 - Elsevier BV | Journal of Thrombosis and Haemostasis
Anders Vik, E. B. Mathiesen, Jan Brox, Tom Wilsgaard, Inger Njølstad, Lone Jørgensen, John‐Bjarne Hansen,
Summary. Background: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). Patients/methods: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross-sectional study including 6516 subjects aged 25–85 years who participated in a population-based health survey. Results: CIMT ...
Tópico(s): Lipoproteins and Cardiovascular Health
2010 - Elsevier BV | Journal of Thrombosis and Haemostasis
Anders Vik, Ellisiv B. Mathiesen, Stein Harald Johnsen, Jan Brox, Tom Wilsgaard, Inger Njølstad, J.-B. Hansen,
Intervention studies in animal models suggest that osteoprotegerin (OPG) functions as an inhibitor or marker of atherosclerosis, whereas one prospective epidemiological study in humans indicated that OPG was an independent risk factor for progression of atherosclerosis.To study the association between serum levels of OPG, soluble RANK ligand (sRANKL) and carotid artery plaque formation and plaque growth.The prevalence of carotid plaque and plaque area were assessed by ultrasonographic imaging at baseline ...
Tópico(s): Bone health and osteoporosis research
2010 - Elsevier BV | Journal of Thrombosis and Haemostasis
Jan‐Magnus Kvamme, Tom Wilsgaard, Jon Florholmen, Bjarne K. Jacobsen,
Tópico(s): Nutritional Studies and Diet
2010 - Springer Science+Business Media | European Journal of Epidemiology
Anette Varbo, Børge G. Nordestgaard,
... 75:1, (5-8), Online publication date: 1-Jan-2022. Machlik M, Hopstock L, Wilsgaard T and Hansson P (2021) Associations Between Intake ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2016 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Tom Wilsgaard, Bjarne K. Jacobsen, Luai A. Ahmed, Ragnar M. Joakimsen, Jan Störmer, Lone Jørgensen,
Tópico(s): Bone health and treatments
2010 - Springer Science+Business Media | Osteoporosis International
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson, Ellen M. Schmidt, Toby Johnson, Guðmar Þorleifsson, Jian’an Luan, Lousie A Donnelly, Stavroula Kanoni, Ann-Kristin Petersen, Vasyl Pihur, Rona J. Strawbridge, Dmitry Shungin, Maria Hughes, Osorio Meirelles, Marika Kaakinen, Nabila Bouatia‐Naji, Kati Kristiansson, Sonia Shah, Marcus E. Kleber, Xiuqing Guo, Leo‐Pekka Lyytikäinen, Cristiano Fava, Niclas Eriksson, Ilja M. Nolte, Patrik K. E. Magnusson, Elias Salfati, Lοukianos S. Rallidis, Elizabeth Theusch, Andrew J. Smith, Lasse Folkersen, Kate Witkowska, Tune H. Pers, Roby Joehanes, Stuart K. Kim, Lazaros Lataniotis, Rick Jansen, Andrew D. Johnson, Helen R. Warren, Young Jin Kim, Wei Zhao, Ying Wu, Bamidele O. Tayo, Murielle Bochud, Devin Absher, Linda S. Adair, Najaf Amin, Dan E. Arking, Tomas Axelsson, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Michael R. Barnes, Inês Barroso, Steve Bevan, Joshua C. Bis, Gyða Björnsdóttir, Michael Boehnke, Eric Boerwinkle, Lori L. Bonnycastle, Dorret I. Boomsma, Stefan R. Bornstein, Morris J. Brown, Michel Burnier, Claudia Cabrera, John C. Chambers, I‐Shou Chang, Ching‐Yu Cheng, Peter S. Chines, Ren-Hua Chung, Francis S. Collins, John Connell, Angela Döring, Jean Dallongeville, John Danesh, Ulf dé Fairé, Graciela Delgado, Anna F. Dominiczak, Alex S. F. Doney, Fotios Drenos, Sarah Edkins, John D. Eicher, Roberto Elosúa, Stefan Enroth, Jeanette Erdmann, Per Eriksson, Tõnu Esko, Εvangelos Εvangelou, Alun Evans, Tove Fall, Martin Farrall, Janine F. Felix, Jean Ferrières, Luigi Ferrucci, Myriam Fornage, Terrence Forrester, Nora Franceschini, Oscar H Franco Duran, Anders Franco‐Cereceda, Ross M. Fraser, Santhi K Ganesh, He Gao, Karl Gertow, Francesco Gianfagna, Bruna Gigante, Franco Giulianini, Anuj Goel, Alison H. Goodall, Mark O Goodarzi, Mathias Gorski, Jürgen Gräßler, Christopher J. Groves, Vilmundur Guðnason, Ulf Gyllensten, Göran Hallmans, Anna-Liisa Hartikainen, Maija Hassinen, Aki S. Havulinna, Caroline Hayward, Serge Herçberg, Karl-Heinz Herzig, Andrew A. Hicks, Aroon D. Hingorani, Joel N. Hirschhorn, Albert Hofman, Jostein Holmen, Oddgeir L. Holmen, Jouke‐Jan Hottenga, Phil Howard, Chao A. Hsiung, Steven C. Hunt, M. Arfan Ikram, Thomas Illig, Carlos Iribarren, Richard A. Jensen, Mika Kähönen, Hyun Min Kang, Sekar Kathiresan, Brendan J. Keating, Kay‐Tee Khaw, Yun Kyoung Kim, Eric H. Kim, Mika Kivimäki, Norman Klopp, Genovefa Kolovou, Pirjo Komulainen, Jaspal S. Kooner, Gülüm Kosova, Ronald M. Krauss, Diana Kuh, Zoltán Kutalik, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Sang Lee, I‐Te Lee, Wen‐Jane Lee, Daniel Levy, Xiaohui Li, Kae-Woei Liang, Honghuang Lin, Lin Li, Jaana Lindström, Stéphane Lobbens, Satu Männistö, Gabriele Müller, Martina Müller‐Nurasyid, François Mach, Hugh S. Markus, Eirini Marouli, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Cristina Menni, Andres Metspalu, Vladan Mijatovic, Leena Moilanen, May E. Montasser, Andrew D Morris, Alanna C. Morrison, Antonella Mulas, Ramaiah Nagaraja, Narisu Narisu, Kjell Nikus, Christopher J. O’Donnell, Paul F. O’Reilly, Ken K. Ong, Fred Paccaud, Cameron D. Palmer, Afshin Parsa, Nancy L. Pedersen, Brenda W.J.H. Penninx, Markus Perola, Annette Peters, Neil Poulter, Peter P. Pramstaller, Bruce M. Psaty, Thomas Quertermous, Dabeeru C Rao, Asif Rasheed, N. William Rayner, Frida Renström, Rainer Rettig, Kenneth Rice, Robert Roberts, Lynda M. Rose, Jacques Rossouw, Nilesh J. Samani, Serena Sanna, Jouko Saramies, Heribert Schunkert, Sylvain Sebért, Wayne H-H Sheu, Young-Ah Shin, Xueling Sim, Johannes H. Smit, Albert V. Smith, Maria X. Sosa, Tim D. Spector, Alena Stančáková, Alice Stanton, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Amy J. Swift, Ann‐Christine Syvänen, E. Shyong Tai, Toshiko Tanaka, Kirill V. Tarasov, Alexander Teumer, Unnur Thorsteinsdottir, Martin D. Tobin, Elena Tremoli, André G. Uitterlinden, Matti Uusitupa, Ahmad Vaez, Dhananjay Vaidya, Cornelia M. van Duijn, Erik P.A. van Iperen, Ramachandran S. Vasan, Germaine C. Verwoert, Jarmo Virtamo, Véronique Vitart, Benjamin F. Voight, Péter Vollenweider, Aline Wagner, Louise V. Wain, Nicholas J. Wareham, Hugh Watkins, Alan B. Weder, Harm-Jan Westra, Rainford Wilks, Tom Wilsgaard, James F Wilson, Tien Yin Wong, Tsun-Po Yang, Jie Yao, Loïc Yengo, Weihua Zhang, Jing Hua Zhao, Xiaofeng Zhu, Pascal Bovet, Stephen S. Rich, Karen L Mohlke, Danish Saleheen, Jong‐Young Lee, Paul Elliott, Hinco J. Gierman, Cristen J. Willer, Lude Franke, G. Kees Hovingh, Kent D. Taylor, George Dedoussis, Peter S. Sever, Andrew Wong, Lars Lind, Themistocles L. Assimes, Inger Njølstad, Peter E. H. Schwarz, Claudia Langenberg, Harold Snieder, Mark J. Caulfield, Olle Melander, Markku Laakso, Juha Saltevo, Rainer Rauramaa, Jaakko Tuomilehto, Erik Ingelsson, Terho Lehtimäki, Kristian Hveem, Walter Palmas, Winfried März, Meena Kumari, Veikko Salomaa, Yii‐Der I. Chen,
Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells. To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 ...
Nature Portfolio
Laila Arnesdatter Hopstock, Adrian Barnett, Kaare Harald Bønaa, Jan Mannsverk, Inger Njølstad, Tom Wilsgaard,
Seasonal changes in cardiovascular disease (CVD) risk factors may be due to exposure to seasonal environmental variables like temperature and acute infections or seasonal behavioural patterns in physical activity and diet. Investigating the seasonal pattern of risk factors should help determine the causes of the seasonal pattern in CVD. Few studies have investigated the seasonal variation in risk factors using repeated measurements from the same individual, which is important as individual and population ...
Tópico(s): Nutritional Studies and Diet
2012 - BMJ | Journal of Epidemiology & Community Health