Maren Weischer, Børge G. Nordestgaard, Paul D.P. Pharoah, Manjeet K. Bolla, Heli Nevanlinna, Laura J. vanʼt Veer, Montserrat García‐Closas, John L. Hopper, Per Hall, Irene L. Andrulis, Peter Devilee, Peter A. Fasching, Hoda Anton‐Culver, Diether Lambrechts, Maartje J. Hooning, Angela Cox, Graham G. Giles, Barbara Burwinkel, Annika Lindblom, Fergus J. Couch, Graham J. Mann, Grethe Grenaker Alnæs, Esther M. John, Thilo Dörk, Henrik Flyger, Alison M. Dunning, Qin Wang, Taru Muranen, Richard van Hien, Jonine D. Figueroa, Melissa C. Southey, Kamila Czene, Julia A. Knight, Rob A.�E.�M. Tollenaar, Matthias W. Beckmann, Argyrios Ziogas, Marie‐Rose Christiaens, Johanna Margriet Collée, Malcolm Reed, Gianluca Severi, Frederik Marmé, Sara Margolin, Janet E. Olson, Veli‐Matti Kosma, Vessela N. Kristensen, Alexander Miron, Natalia Bogdanova, Mitul Shah, Carl Blomqvist, Annegien Broeks, Mark E. Sherman, Kelly‐Anne Phillips, Jingmei Li, Jianjun Liu, Gord Glendon, Caroline Seynaeve, Arif B. Ekici, Karin Leunen, Mieke Kriege, Simon S. Cross, Laura Baglietto, Christof Sohn, Xianshu Wang, Vesa Kataja, Anne‐Lise Børresen‐Dale, Andreas Meyer, Douglas F. Easton, Marjanka K. Schmidt, Stig E. Bojesen,
We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific death, and risk of a second breast cancer in women with a first breast cancer.From 22 studies participating in the Breast Cancer Association Consortium, 25,571 white women with invasive breast cancer were genotyped for CHEK2*1100delC and observed for up to 20 years (median, 6.6 years). We examined risk of early death and breast cancer-specific death by estrogen receptor ...
Tópico(s): Genetic factors in colorectal cancer
2012 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Stephen C. Textor, Kim Margolin, Douglas W. Blayney, Janet F. Carlson, James Doroshow,
Changes in blood pressure, renal function, and fluid balance were studied in 12 patients receiving intravenous recombinant interleukin-2 (IL-2) (100,000 units/kg every eight hours) over five days for treatment of metastatic melanoma and renal and colorectal cancers. The IL-2 regimen produced progressive hypotension, azotemia, and sodium avidity (fractional excretion of sodium = 0.20 ± 0.07 percent) despite massive fluid administration (mean: 18.4 liter per five days) and weight gain (mean: 4.0 kg). Plasma ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
1987 - Elsevier BV | The American Journal of Medicine
John R. B. Perry, Yi-Hsiang Hsu, Daniel I. Chasman, Andrew D. Johnson, Cathy E. Elks, Eva Albrecht, Irene L. Andrulis, Jonathan Beesley, Gerald S. Berenson, Sven Bergmann, Stig E. Bojesen, Manjeet K. Bolla, Judith Brown, Julie E. Buring, Harry Campbell, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Tanguy Corre, Fergus J. Couch, Angela Cox, Kamila Czene, Pio D’Adamo, Gail Davies, Ian J. Deary, Joe Dennis, Douglas F. Easton, Ellen G. Engelhardt, Johan G. Eriksson, Tõnu Esko, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Abigail Fraser, Montserrat García‐Closas, Paolo Gasparini, Christian Gieger, Graham G. Giles, Pascal Guénel, Sara Hägg, Per Hall, Caroline Hayward, John L. Hopper, Erik Ingelsson, Sharon L. R. Kardia, Katherine Kasiman, Julia A. Knight, Jari Lahti, Debbie A. Lawlor, Patrik K. E. Magnusson, Sara Margolin, Julie Marsh, Andres Metspalu, Janet E. Olson, Craig E. Pennell, Ozren Polašek, Iffat Rahman, Paul M. Ridker, Antonietta Robino, Igor Rudan, Anja Rudolph, Andres Salumets, Marjanka K. Schmidt, Minouk J. Schoemaker, Erin N. Smith, Jennifer A. Smith, Melissa C. Southey, Doris Stöckl, Anthony J. Swerdlow, Deborah J. Thompson, Thérèse Truong, Sheila Ulivi, Mélanie Waldenberger, Qin Wang, Sarah H. Wild, James F. Wilson, Alan F. Wright, Lina Zgaga, Ken K. Ong, Joanne M. Murabito, David Karasik, Anna Murray,
The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain <15% of the genetic component. We have used genome-wide association in a bivariate meta- ...
Tópico(s): Digestive system and related health
2013 - Oxford University Press | Human Molecular Genetics
Stanley Hattman, Janet Ives, William Margolin, Martha M. Howe,
Expression of the bacteriophage Mu mom gene is under tight regulatory control. One of the factors required for mom gene expression is the (trans-acting function (designated Dad) provided by another Mu gene. To facilitate studies on the signals mediating mom regulation, we have constructed a mom-lacZ fusion plasmid which synthesizes β-galactosidase only when the Mu Dad transactivating function is provided. λpMu phages carrying different segments of the Mu genome have been assayed for their ability ...
Tópico(s): RNA and protein synthesis mechanisms
1985 - Elsevier BV | Gene
Peter A. Fasching, Paul D.P. Pharoah, Angela Cox, Heli Nevanlinna, Stig E. Bojesen, Thomas Karn, Annegien Broeks, Flora E. van Leeuwen, Laura van ′t Veer, Renate Udo, Alison M. Dunning, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Mitul Shah, Børge G. Nordestgaard, Henrik Flyger, John L. Hopper, Melissa C. Southey, Carmel Apicella, Montserrat García‐Closas, Mark E. Sherman, Jolanta Lissowska, Caroline Seynaeve, Petra E.A. Huijts, Rob A.�E.�M. Tollenaar, Argyrios Ziogas, Arif B. Ekici, Claudia Rauh, Graham J. Mann, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Irene L. Andrulis, Hilmi Özçelik, Anna Marie Mulligan, Gord Glendon, Per Hall, Kamila Czene, Jianjun Liu, Jenny Chang‐Claude, Shan Wang‐Gohrke, Ursula Eilber, Stefan Nickels, Thilo Dörk, Maria Schiekel, Michael Bremer, Tjoung‐Won Park‐Simon, Graham G. Giles, Gianluca Severi, Laura Baglietto, Maartje J. Hooning, John W.M. Martens, Agnes Jager, Mieke Kriege, Annika Lindblom, Sara Margolin, Fergus J. Couch, Kristen N. Stevens, Janet E. Olson, Matthew Kosel, Simon S. Cross, Sabapathy P. Balasubramanian, Malcolm Reed, Alexander Miron, Esther M. John, Robert Winqvist, Katri Pylkäs, Arja Jukkola‐Vuorinen, Saila Kauppila, Barbara Burwinkel, Frederik Marmé, Andreas Schneeweiß, Christof Sohn, Georgia Chenevix‐Trench, Diether Lambrechts, Anne-Sophie Dieudonné, Sigrid Hatse, Erik Van Limbergen, Javier Benı́tez, Roger L. Milne, M. Pilar Zamora, José Ignacio Arias Pérez, Bernardo Bonanni, Bernard Peissel, Bernard Loris, Paolo Peterlongo, Preetha Rajaraman, Sara J. Schonfeld, Hoda Anton‐Culver, Peter Devilee, Matthias W. Beckmann, Dennis J. Slamon, Kelly‐Anne Phillips, Jonine D. Figueroa, Manjeet K. Humphreys, Douglas F. Easton, Marjanka K. Schmidt,
Recent genome-wide association studies identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. We investigated these and 62 other SNPs for their prognostic relevance. Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other ...
Tópico(s): Genetic factors in colorectal cancer
2012 - Oxford University Press | Human Molecular Genetics
Arthur Margolin, Herbert D. Kleber, S. Kelly Avants, Janet Konefal, Frank H. Gawin, Elena Stark, James L. Sorensen, Eleanor E. Midkiff, Elizabeth A. Wells, T. Ron Jackson, Milton L. Bullock, Patricia D. Culliton, Sharon Boles, Roger Vaughan,
Auricular acupuncture is widely used to treat cocaine addiction in the United States and Europe. However, evidence from controlled studies regarding this treatment's effectiveness has been inconsistent.To investigate the effectiveness of auricular acupuncture as a treatment for cocaine addiction.Randomized, controlled, single-blind clinical trial conducted from November 1996 to April 1999.Six community-based clinics in the United States: 3 hospital-affiliated clinics and 3 methadone maintenance ...
Tópico(s): Forensic Toxicology and Drug Analysis
2002 - American Medical Association | JAMA
Drew Margolin, Cuihua Shen, Seungyoon Lee, Matthew S. Weber, Janet Fulk, Peter R. Monge,
This study examines the impact of legitimacy on the dynamics of interorganizational networks within the nongovernmental organizations’ children’s rights community. The 27-year period of analysis included a critical community event: the ratification of the United Nations Convention on the Rights of the Child (UNCRC). Building on theories of organizational evolution, hypotheses proposed that (1) ratification of the UNCRC served to codify and more broadly communicate the legitimate norms of the community, ...
Tópico(s): Evaluation and Performance Assessment
2012 - SAGE Publishing | Communication Research
Gregori Margolin, Gertrude Huster, Charles J. Glueck, James Speirs, Janet Vandegrift, Ellen Illig, Joseph Wu, Patricia Streicher, Trent Tracy,
In 46 elderly (aged ≥ 60 y) hypertensive subjects with entry systolic blood pressure (SBP) ≥ 160 or diastolic blood pressure (DBP) ≥ 90 mm Hg, our specific aim in a randomized, double-blind, crossover study (two 8-wk treatment periods separated by a 3-wk washout) was to compare blood pressure–lowering effects of 9 g fish oil/d [ω-3 (n–3) fatty acid] vs 9 g corn oil/d [ω-6 (n–6) fatty acid]. After a 4-wk baseline period, 22 subjects were randomly assigned to receive fish oil and 24 to receive corn oil. For both ...
Tópico(s): Diet, Metabolism, and Disease
1991 - Elsevier BV | American Journal of Clinical Nutrition
D. Ross Camidge, Eudocia Q. Lee, Nancy U. Lin, Kim Margolin, Manmeet S. Ahluwalia, Martin Bendszus, Susan M. Chang, Janet Dancey, Elisabeth G.E. de Vries, Gordon J. Harris, F. Stephen Hodi, Andrew B. Lassman, David R. Macdonald, David M. Peereboom, David Schiff, Riccardo Soffietti, Martin J. van den Bent, Jeffrey S. Wefel, Patrick Y. Wen,
Patients with active CNS disease are often excluded from clinical trials, and data regarding the CNS efficacy of systemic agents are usually obtained late in the drug development process or not at all. In this guideline from the Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) working group, we provide detailed recommendations on when patients with brain metastases from solid tumours should be included or excluded in clinical trials of systemic agents. We also discuss the limitations ...
Tópico(s): Lung Cancer Research Studies
2017 - Elsevier BV | The Lancet Oncology
Shahana Ahmed, Gilles Thomas, Maya Ghoussaini, Catherine S. Healey, Manjeet K. Humphreys, Radka Platte, Jonathan J. Morrison, Melanie Maranian, Karen A. Pooley, Robert Luben, Diana Eccles, D. Gareth Evans, Olivia Fletcher, Nichola Johnson, Isabel dos‐Santos‐Silva, Julian Peto, Michael R. Stratton, Nazneen Rahman, Kevin B. Jacobs, Ross L. Prentice, Garnet L. Anderson, Aleksandar Rajkovic, J. David Curb, Regina G. Ziegler, Christine D. Berg, Saundra S. Buys, Catherine A. McCarty, Heather Spencer Feigelson, Eugenia E. Calle, Michael J. Thun, W. Ryan Diver, Stig E. Bojesen, Børge G. Nordestgaard, Henrik Flyger, Thilo Dörk, Peter Schürmann, Peter Hillemanns, Johann H. Karstens, Natalia Bogdanova, Natalia Antonenkova, Iosif V. Zalutsky, Marina Bermisheva, С.А. Федорова, Э. К. Хуснутдинова, Daehee Kang, Keun-Young Yoo, Dong‐Young Noh, Sei-Hyun Ahn, Peter Devilee, Christi J. van Asperen, Robert A.E.M. Tollenaar, Caroline Seynaeve, Montserrat García‐Closas, Jolanta Lissowska, Louise A. Brinton, Beata Pepłońska, Heli Nevanlinna, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist, John L. Hopper, Melissa C. Southey, Letitia Smith, Amanda B. Spurdle, Marjanka K. Schmidt, Annegien Broeks, Richard R van Hien, Sten Cornelissen, Roger L. Milne, Glòria Ribas, Anna González‐Neira, Javier Benı́tez, Rita K. Schmutzler, Barbara Burwinkel, Claus R. Bartram, Alfons Meindl, Hiltrud Brauch, Christina Justenhoven, Ute Hamann, Jenny Chang‐Claude, Rebecca Hein, Shan Wang‐Gohrke, Annika Lindblom, Sara Margolin, Graham J. Mann, Veli-Matti Kosma, Vesa Kataja, Janet E. Olson, Xianshu Wang, Zachary Fredericksen, Graham G. Giles, Gianluca Severi, Laura Baglietto, Dallas R. English, Susan E. Hankinson, David G. Cox, Peter Kraft, Lars J. Vatten, Kristian Hveem, Merethe Kumle, Alice J. Sigurdson, Michele M. Doody, Parveen Bhatti, Bruce H. Alexander, Maartje J. Hooning, Ans M.W. van den Ouweland, Rogier A. Oldenburg, Mieke Schutte, Per Hall, Kamila Czene, Jianjun Liu, Yuqing Li, Angela Cox, Graeme Elliott, Ian W. Brock, Malcolm Reed, Chen‐Yang Shen, Jyh-Cherng Yu, Giu-Cheng Hsu, Shou-Tung Chen, Hoda Anton‐Culver, Argyrios Ziogas, Irene L. Andrulis, Julia A. Knight, Jonathan Beesley, Ellen L. Goode, Fergus J. Couch, Georgia Chenevix‐Trench, Robert N. Hoover, Bruce A.J. Ponder, David J. Hunter, Paul D.P. Pharoah, Alison M. Dunning, Stephen J. Chanock, Douglas F. Easton,
Douglas Easton and colleagues report results of a large multistage genome-wide association study of breast cancer. The study identifies two new breast cancer risk loci on chromosomes 3p24 and 17q23.2. Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and ...
Tópico(s): Genomics and Chromatin Dynamics
2009 - Nature Portfolio | Nature Genetics
Maral Jamshidi, Rainer Fagerholm, Sofia Khan, Kristiina Aittomäki, Kamila Czene, Hatef Darabi, Jingmei Li, Irene L. Andrulis, Jenny Chang‐Claude, Peter Devilee, Peter A. Fasching, Kyriaki Michailidou, Manjeet K. Bolla, Joe Dennis, Sophia Wang, Qi Guo, Valerie Rhenius, Sten Cornelissen, Anja Rudolph, Julia A. Knight, Christian R. Loehberg, Barbara Burwinkel, Frederik Marmé, John L. Hopper, Melissa C. Southey, Stig E. Bojesen, Henrik Flyger, Hermann Brenner, Bernd Holleczek, Sara Margolin, Graham J. Mann, Veli‐Matti Kosma, Laurien Van Dyck, Ines Nevelsteen, Fergus J. Couch, Janet E. Olson, Graham G. Giles, Catriona McLean, Christopher A. Haiman, Brian E. Henderson, Robert Winqvist, Katri Pylkäs, Rob A.�E.�M. Tollenaar, Montserrat García‐Closas, Jonine D. Figueroa, Maartje J. Hooning, John W.M. Martens, Angela Cox, Simon S. Cross, Jacques Simard, Alison M. Dunning, Douglas F. Easton, Paul D.P. Pharoah, Per Hall, Carl Blomqvist, Marjanka K. Schmidt, Heli Nevanlinna,
... Brenner 26,27,28 , Bernd Holleczek 29 , Sara Margolin 30 , Arto Mannermaa 31,32,33 , Veli-Matti Kosma 31,32,33 , kConFab Investigators 34 , Laurien Van Dyck 35,36 , Ines Nevelsteen 37 , Fergus J. Couch 38 , Janet E. Olson 39 , Graham G. Giles 40,41 , ...
Tópico(s): Natural product bioactivities and synthesis
2015 - Impact Journals LLC | Oncotarget
Miguel de la Hoya, Omar Soukarieh, Irene López‐Perolio, Ana Vega, Logan C. Walker, Yvette van Ierland, Diana Baralle, Marta Santamariña, Vanessa Lattimore, Juul Wijnen, Philip J. Whiley, Ana Blanco, Michela Raponi, Jan Hauke, Barbara Wappenschmidt, Alexandra Becker, Thomas van Overeem Hansen, Raquel Behar, kConFab Investigators, Diether Niederacher, Norbert Arnold, Bernd Dworniczak, Doris Steinemann, Ulrike Faust, Wendy S. Rubinstein, Peter J. Hulick, Claude Houdayer, Sandrine M. Caputo, Laurent Castéra, Tina Pesaran, Elizabeth Chao, Carole Brewer, Melissa C. Southey, Christi J. van Asperen, Christian F. Singer, Jan Sullivan, Nicola Poplawski, Phuong Mai, Julian Peto, Nichola Johnson, Barbara Burwinkel, Harald Surowy, Stig E. Bojesen, Henrik Flyger, Annika Lindblom, Sara Margolin, Jenny Chang‐Claude, Anja Rudolph, Paolo Radice, Laura Galastri, Janet E. Olson, Emily Hallberg, Graham G. Giles, Roger L. Milne, Irene L. Andrulis, Gord Glendon, Per Hall, Kamila Czene, Fiona M. Blows, Mitul Shah, Qin Wang, Joe Dennis, Kyriaki Michailidou, Lesley McGuffog, Manjeet K. Bolla, Antonis C. Antoniou, Douglas F. Easton, Fergus J. Couch, Sean V. Tavtigian, Maaike P.G. Vreeswijk, Michael T. Parsons, Huong Meeks, Alexandra Martins, David E. Goldgar, Amanda B. Spurdle,
A recent analysis using family history weighting and co-observation classification modeling indicated that BRCA1 c.594-2A > C (IVS9-2A > C), previously described to cause exon 10 skipping (a truncating alteration), displays characteristics inconsistent with those of a high risk pathogenic BRCA1 variant. We used large-scale genetic and clinical resources from the ENIGMA, CIMBA and BCAC consortia to assess pathogenicity of c.594-2A > C. The combined odds for causality considering case-control, segregation ...
Tópico(s): Genomic variations and chromosomal abnormalities
2016 - Oxford University Press | Human Molecular Genetics
Janet McCracken, Richard Buchanan, Victor Margolin, Dennis Doordan, Paul Jobling, David Crowley, Günther Kress, Theo van Leeuwen, Victor Margolin, Richard Buchanan, J E G PALMER, Mo Dodson,
This text reflects the growing recognition that the design of the everyday world deserves attention not only as a professional practice but as a subject of social, cultural and philosophic investigation. Victor Margolin, co-founder and an editor of Design Issues, and Richard Buchanan, also an editor of the same journal, bring together 11 essays by scholars in fields ranging from psychology, sociology and political theory to technology studies, rhetoric and philosophy. The essayists share the editors' ...
Tópico(s): Visual Culture and Art Theory
2000 - Oxford University Press | Journal of Aesthetics and Art Criticism
Mara Colombo, Irene López‐Perolio, Huong Meeks, Laura Caleca, Michael T. Parsons, Hongyan Li, Giovanna De Vecchi, Emma Tudini, Claudia Foglia, P Mondini, Siranoush Manoukian, Raquel Behar, E. Gómez, Thomas Ind, Marco Montagna, Dieter Niederacher, Ane Yde Schmidt, Liliana Varesco, Barbara Wappenschmidt, Manjeet K. Bolla, Joe Dennis, Kyriaki Michailidou, Qin Wang, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly-Fadel, Javier Benı́tez, Bram Boeckx, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang‐Claude, Don Conroy, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Mikael Eriksson, Peter A. Fasching, Jonine D. Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Montserrat García‐Closas, Graham G. Giles, Anna González‐Neira, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Mikael Hartman, Jan Hauke, Antoinette Hollestelle, John L. Hopper, Anna Jakubowska, Audrey Jung, Veli‐Matti Kosma, Diether Lambrechts, Loid Le Marchand, Annika Lindblom, Jan Lubiński, Arto Mannermaa, Sara Margolin, Hui Miao, Roger L. Milne, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Paolo Peterlongo, Julian Peto, Katri Pylkäs, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Andreas Schneeweiß, Minouk J. Schoemaker, Mee‐Hoong See, Melissa C. Southey, Anthony J. Swerdlow, Soo‐Hwang Teo, Amanda E. Toland, Ian Tomlinson, Thérèse Truong, Christi J. van Asperen, Ans M.W. van den Ouweland, Lizet E. van der Kolk, Robert Winqvist, Drakoulis Yannoukakos, Wei Zheng, Alison M. Dunning, Douglas F. Easton, Alex Henderson, Frans B.L. Hogervorst, Louise Izatt, Kenneth Offitt, Lucy Side, Elizabeth J. van Rensburg, Study EMBRACE, Study HEBON, Lesley McGuffog, Antonis C. Antoniou, Georgia Chenevix‐Trench, Amanda B. Spurdle, David E. Goldgar, Miguel de la Hoya, Paolo Radice,
Although the spliceogenic nature of the BRCA2 c.68-7T > A variant has been demonstrated, its association with cancer risk remains controversial. In this study, we accurately quantified by real-time PCR and digital PCR (dPCR), the BRCA2 isoforms retaining or missing exon 3. In addition, the combined odds ratio for causality of the variant was estimated using genetic and clinical data, and its associated cancer risk was estimated by case-control analysis in 83,636 individuals. Co-occurrence in trans ...
Tópico(s): Genomics and Rare Diseases
2018 - Wiley | Human Mutation
Vernon D. Miller, Marshall Scott Poole, David R. Seibold, Karen K. Myers, Hee Sun Park, Peter R. Monge, Janet Fulk, Lauren B. Frank, Drew Margolin, Courtney M. Schultz, Cuihua Shen, Matthew S. Weber, Seungyoon Lee, Michelle Shumate,
This article showcases current best practices in quantitative organizational communication research. We emphasize their value in exploring issues of the day and their relation to other research approaches. Materials are presented around four themes: systematic development and validation of measures, including the use of mixed methods; multiple levels of analysis; the study of change and development over time; and relationships among people, units, organizations, and meanings.
Tópico(s): Public Relations and Crisis Communication
2011 - SAGE Publishing | Management Communication Quarterly
Patrick A. Zweidler‐McKay, Mary‐Jane Staba Hogan, Rima Jubran, Vandy Black, Jacqueline Casillas, James Harper, Suman Malempati, Judith Margolin, Judy Felgenhauer, Kathleen M. Sakamoto, Janet Franklin, Mona D. Shah, Nita L. Seibel, George R. Buchanan, Sarah R. Vaiselbuh, Caroline A. Hastings, Joanne M. Hilden, Linda C. Stork,
Pediatric Blood & CancerVolume 63, Issue 10 p. 1723-1730 Special Report Navigating your career path in pediatric hematology/oncology: On and off the beaten track Patrick A. Zweidler-McKay, Patrick A. Zweidler-McKay Division of Pediatrics, UT M.D. Anderson Cancer Center, Children's Cancer Hospital, Houston, TexasSearch for more papers by this authorMary-Jane Staba Hogan, Mary-Jane Staba Hogan Department of Pediatrics, Yale University School of Medicine, New Haven, ConnecticutSearch for more papers ...
Tópico(s): Acute Lymphoblastic Leukemia research
2016 - Wiley | Pediatric Blood & Cancer
Janet Townsley-Fuchs, Mehran S. Neshat, David Margolin, Jonathan Braun, Leegoodglick,
The envelope glycoprotein of the human immunodeficiency virus (HIV-1), gp120, has recently been characterized as a novel immunoglobulin superantigen (Ig-SAg) [1,2]. Analogous to the interaction of SAgs with T cells, gp120 binds to an unusually large proportion of immunoglobulins (Igs) from HIV-uninfected individuals; most, if not all of these Igs are members of the VH3 family [3]. Functionally, gp 120 preferentially stimulates VH3 B cells in vitro. This stimulation correlates with an in vivo VH3 activation ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1997 - Taylor & Francis | International Reviews of Immunology
David Margolin, Maria Kousi, Yee-Ming Chan, Elaine T. Lim, Jeremy D. Schmahmann, Marios Hadjivassiliou, Janet E. Hall, Ibrahim Ismael Adam, Andrew Dwyer, Lacey Plummer, Stephanie V. Aldrin, Julia O’Rourke, Andrew Kirby, Kasper Lage, Aubrey Milunsky, Jeff M. Milunsky, Jennifer A. Chan, E. Tessa Hedley‐Whyte, Mark J. Daly, Nicholas Katsanis, Stephanie B. Seminara,
The combination of ataxia and hypogonadism was first described more than a century ago, but its genetic basis has remained elusive.We performed whole-exome sequencing in a patient with ataxia and hypogonadotropic hypogonadism, followed by targeted sequencing of candidate genes in similarly affected patients. Neurologic and reproductive endocrine phenotypes were characterized in detail. The effects of sequence variants and the presence of an epistatic interaction were tested in a zebrafish model. ...
Tópico(s): Mitochondrial Function and Pathology
2013 - Massachusetts Medical Society | New England Journal of Medicine
Produção Nacional
Revisado por pares
Qi Guo, Marjanka K. Schmidt, Peter Kraft, Sander Canisius, Constance Chen, Sofia Khan, Jonathan P. Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Siddhartha Kar, Jonathan Beesley, Alison M. Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Diether Lambrechts, Caroline Weltens, Karin Leunen, Stig E. Bojesen, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Jenny Chang‐Claude, Anja Rudolph, Petra Seibold, Dieter Flesch‐Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru Muranen, Fergus J. Couch, Janet E. Olson, Celine M. Vachon, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Frans B.L. Hogervorst, Christopher A. Haiman, Brian E. Henderson, Fredrick R. Schumacher, Loı̈c Le Marchand, John L. Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C. Southey, Angela Cox, Simon S. Cross, Malcolm Reed, Graham G. Giles, Roger L. Milne, Catriona McLean, Robert Winqvist, Katri Pylkäs, Arja Jukkola‐Vuorinen, Mervi Grip, Maartje J. Hooning, Antoinette Hollestelle, John W.M. Martens, Ans M.W. van den Ouweland, F. Marmé, Andreas Schneeweiß, Rongxi Yang, Barbara Burwinkel, Jonine D. Figueroa, Stephen J. Chanock, Jolanta Lissowska, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Bernd Holleczek, Graham J. Mann, Vesa Kataja, Veli‐Matti Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, Keith Humphreys, Peter Devilee, Rob A.�E.�M. Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, P. Mariani, Peter A. Fasching, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Georgia Chenevix‐Trench, Rosemary L. Balleine, Kelly‐Anne Phillips, Javier Benı́tez, M. Pilar Zamora, José Ignacio Arias Pérez, Primitiva Menéndez, Anna Jakubowska, Jan Lubiński, Katarzyna Jaworska–Bieniek, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela N. Kristensen, Silje Nord, D. Gareth Evans, Jean Abraham, Helena Earl, Louise Hiller, Janet Dunn, S. Bowden, Christine D. Berg, Daniele Campa, W. Ryan Diver, Susan M. Gapstur, Mia M. Gaudet, Susan E. Hankinson, Robert N. Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J. Machiela, Walter C. Willett, Myrto Barrdahl, Federico Canzian, Suet‐Feung Chin, Carlos Caldas, David J. Hunter, Sara Lindström, Montserrat García‐Closas, Per Hall, Douglas F. Easton, Diana Eccles, Nazneen Rahman, Heli Nevanlinna, Paul D.P. Pharoah,
Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with breast cancer–specific survival. We conducted a large meta-analysis of studies in populations of European ancestry, including 37954 patients with 2900 deaths from breast cancer. Each study had been genotyped for between 200000 and 900000 single nucleotide polymorphisms (SNPs) across the genome; ...
Tópico(s): Cancer Genomics and Diagnostics
2015 - Oxford University Press | JNCI Journal of the National Cancer Institute
Rainer Fagerholm, Marjanka K. Schmidt, Sofia Khan, Sajjad Rafiq, William Tapper, Kristiina Aittomäki, Dario Greco, Tuomas Heikkinen, Taru Muranen, Peter A. Fasching, Wolfgang Janni, Richard M. Weinshilboum, Christian R. Loehberg, John L. Hopper, Melissa C. Southey, Renske Keeman, Annika Lindblom, Sara Margolin, Graham J. Mann, Vesa Kataja, Georgia Chenevix‐Trench, kConFab Investigators, Diether Lambrechts, Hans Wildiers, Jenny Chang‐Claude, Petra Seibold, Fergus J. Couch, Janet E. Olson, Irene L. Andrulis, Julia A. Knight, Montserrat García‐Closas, Jonine D. Figueroa, Maartje J. Hooning, Agnes Jager, Mitul Shah, Barbara Perkins, Robert Luben, Ute Hamann, Maria Kabisch, Kamila Czene, Per Hall, Douglas F. Easton, Paul D.P. Pharoah, Jianjun Liu, Diana Eccles, Carl Blomqvist, Heli Nevanlinna,
... 11 , Renske Keeman 2 , Annika Lindblom 12 , Sara Margolin 13 , Arto Mannermaa 14,15,16 , Vesa Kataja 17 , Georgia Chenevix-Trench 18 , kConFab Investigators 19 , Diether Lambrechts 20,21 , Hans Wildiers 22 , Jenny Chang-Claude 23 , Petra Seibold 23 , Fergus J. Couch 24 , Janet E. Olson 25 , Irene L. Andrulis 26,27 , ...
Tópico(s): Microtubule and mitosis dynamics
2015 - Impact Journals LLC | Oncotarget
Yan Guo, Shaneda Warren Andersen, Xiao‐Ou Shu, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Montserrat García‐Closas, Roger L. Milne, Marjanka K. Schmidt, Jenny Chang‐Claude, Alison M. Dunning, Stig E. Bojesen, Habibul Ahsan, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, Natalia Bogdanova, Bernardo Bonanni, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Graham Casey, Georgia Chenevix‐Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Martine Dumont, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Marilie D. Gammon, Graham G. Giles, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Farzana Jasmine, Mark A. Jenkins, Esther M. John, Nichola Johnson, Michael E. Jones, Maria Kabisch, Muhammad G. Kibriya, Julia A. Knight, Linetta B. Koppert, Veli‐Matti Kosma, Vessela N. Kristensen, Loı̈c Le Marchand, Eunjung Lee, Jingmei Li, Annika Lindblom, Robert Luben, Jan Lubiński, Kathi Malone, Graham J. Mann, Sara Margolin, Frederik Marmé, Catriona McLean, Hanne Meijers‐Heijboer, Alfons Meindl, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Janet E. Olson, José Ignacio Arias Pérez, Barbara Perkins, Paolo Peterlongo, Kelly‐Anne Phillips, Katri Pylkäs, Anja Rudolph, Regina M. Santella, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Mitul Shah, Martha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Amanda E. Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Giske Ursin, Rob B. van der Luijt, Senno Verhoef, Alice S. Whittemore, Robert Winqvist, Hui Zhao, Shilin Zhao, Per Hall, Jacques Simard, Peter Kraft, Paul D.P. Pharoah, David J. Hunter, Douglas F. Easton, Wei Zheng,
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors.
Tópico(s): Nutritional Studies and Diet
2016 - Public Library of Science | PLoS Medicine
Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan P. Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M. Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael Eriksson, Diether Lambrechts, Caroline Weltens, Karin Leunen, Chantal Van Ongeval, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch‐Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru Muranen, Janet E Olsen, Emily Hallberg, Celine M. Vachon, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A. Haiman, Brian E. Henderson, Fredrick R. Schumacher, Loı̈c Le Marchand, John L. Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C. Southey, Simon S. Cross, Malcolm Reed, Graham G. Giles, Roger L. Milne, Catriona McLean, Robert Winqvist, Katri Pylkäs, Arja Jukkola‐Vuorinen, Mervi Grip, Maartje J. Hooning, Antoinette Hollestelle, John W.M. Martens, Ans MW van den Ouweland, F Marmé, Andreas Schneeweiß, Rongxi Yang, Barbara Burwinkel, Jonine D. Figueroa, Stephen J. Chanock, Jolanta Lissowska, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, Keith Humphreys, Peter Devilee, Robert A.E.M. Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Rosemary L. Balleine, Kelly‐Anne Phillips, Javier Benı́tez, M. Pilar Zamora, José Ignacio Arias Pérez, Primitiva Menéndez, Anna Jakubowska, Jan Lubiński, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela N. Kristensen, Siljie Nord, D. Gareth Evans, Jean Abraham, Helena Earl, Christopher Poole, Louise Hiller, Janet Dunn, S. Bowden, Rose Yang, Daniele Campa, W. Ryan Diver, Susan M. Gapstur, Mia M. Gaudet, Susan E. Hankinson, Robert N. Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J. Machiela, Walter C. Willett, Myrto Barrdahl, Federico Canzian, Suet‐Feung Chin, Carlos Caldas, David J. Hunter, Sara Lindström, Montserrat García‐Closas, Fergus J. Couch, Georgia Chenevix‐Trench, Graham J. Mann, Irene L. Andrulis, Per Hall, Jenny Chang‐Claude, Douglas F. Easton, Stig E. Bojesen, Angela Cox, Peter A. Fasching, Paul D.P. Pharoah, Marjanka K. Schmidt,
Abstract Introduction Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods A literature review ...
Tópico(s): Nutrition, Genetics, and Disease
2015 - BioMed Central | Breast Cancer Research
Xingyi Guo, Jirong Long, Chenjie Zeng, Kyriaki Michailidou, Maya Ghoussaini, Manjeet K. Bolla, Sophia Wang, Roger L. Milne, Xiao-Ou Shu, Qiuyin Cai, Jonathan Beesley, Siddhartha Kar, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, William J. Blot, Natalia Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Hui Cai, Sander Canisius, Jenny Chang‐Claude, Ji‐Yeob Choi, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Peter Devilee, Arnaud Droit, Thilo Dörk, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Valérie Gaborieau, Montserrat García‐Closas, Graham G. Giles, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Mikael Hartman, Antoinette Hollestelle, John L. Hopper, Chia-Ni Hsiung, Hidemi Ito, Anna Jakubowska, Nichola Johnson, Maria Kabisch, Daehee Kang, Sofia Khan, Julia A. Knight, Veli-Matti Kosma, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubiński, Graham J. Mann, Siranoush Manoukian, Sara Margolin, Frederik Marmé, Keitaro Matsuo, Catriona McLean, Alfons Meindl, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Silje Nord, Janet E. Olson, Nick Orr, Paolo Peterlongo, Thomas Choudary Putti, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Chen‐Yang Shen, Jiajun Shi, Martha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Soo‐Hwang Teo, Bernard Thienpont, Amanda E. Toland, Robert A.E.M. Tollenaar, Ian Tomlinson, Thérèse Truong, Chiu-Chen Tseng, Ans van den Ouweland, Wanqing Wen, Robert Winqvist, Anna H. Wu, Cheng Har Yip, M. Pilar Zamora, Ying Zheng, Per Hall, Paul D.P. Pharoah, Jacques Simard, Georgia Chenevix‐Trench, Alison M. Dunning, Douglas F. Easton, Wei Zheng,
Abstract Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented ...
Tópico(s): Genetic factors in colorectal cancer
2015 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Elizabeth M. Azzato, Jonathan P. Tyrer, Peter A. Fasching, Matthias W. Beckmann, Arif B. Ekici, Rüdiger Schulz‐Wendtland, Stig E. Bojesen, Børge G. Nordestgaard, Henrik Flyger, Roger L. Milne, José Ignacio Arias, Primitiva Menéndez, Javier Benı́tez, Jenny Chang‐Claude, Rebecca Hein, Shan Wang‐Gohrke, Heli Nevanlinna, Tuomas Heikkinen, Kristiina Aittomäki, Carl Blomqvist, Sara Margolin, Graham J. Mann, Veli‐Matti Kosma, Vesa Kataja, Jonathan Beesley, Xiaohong Chen, Georgia Chenevix‐Trench, Fergus J. Couch, Janet E. Olson, Zachary S. Fredericksen, Xianshu Wang, Graham G. Giles, Gianluca Severi, Laura Baglietto, Melissa C. Southey, Peter Devilee, Rob A.�E.�M. Tollenaar, Caroline Seynaeve, Montserrat García‐Closas, Jolanta Lissowska, Mark E. Sherman, Kelly L. Bolton, Per Hall, Kamila Czene, Angela Cox, Ian W. Brock, Graeme Elliott, Malcolm Reed, David Greenberg, Hoda Anton‐Culver, Argyrios Ziogas, Manjeet K. Humphreys, Douglas F. Easton, Neil E. Caporaso, Paul D.P. Pharoah,
Traditional prognostic factors for survival and treatment response of patients with breast cancer do not fully account for observed survival variation. We used available genotype data from a previously conducted two-stage, breast cancer susceptibility genome-wide association study (ie, Studies of Epidemiology and Risk factors in Cancer Heredity [SEARCH]) to investigate associations between variation in germline DNA and overall survival. We evaluated possible associations between overall survival after ...
Tópico(s): BRCA gene mutations in cancer
2010 - Oxford University Press | JNCI Journal of the National Cancer Institute
Joe Dennis, Jonathan P. Tyrer, Logan C. Walker, Kyriaki Michailidou, Leila Dorling, Manjeet K. Bolla, Qin Wang, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton‐Culver, Natalia Antonenkova, Volker Arndt, Kristan J. Aronson, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benı́tez, Marina Bermisheva, Natalia Bogdanova, Stig E. Bojesen, Hermann Brenner, Jose E. Castelao, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Christine L. Clarke, Vessela N. Kristensen, Kristine Kleivi Sahlberg, Anne‐Lise Børresen‐Dale, Inger Torhild Gram, Olav Engebråten, Bjørn Naume, Jürgen Geisler, Grethe I.G. Alnæs, J. Margriet Collée, James V. Lacey, Elena Martínez, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Peter Devilee, Thilo Dörk, Laure Dossus, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine D. Figueroa, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Marike Gabrielson, Manuela Gago‐Dominguez, Montserrat García‐Closas, Graham G. Giles, Anna González‐Neira, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Per Hall, Antoinette Hollestelle, Reiner Hoppe, John L. Hopper, Anthony Howell, Christine L. Clarke, Jane Carpenter, Deborah J. Marsh, Rodney J. Scott, Robert Baxter, Desmond Yip, Alison Davis, Nirmala Pathmanathan, Peter T. Simpson, Dinny Graham, Mythily Sachchithananthan, Ian Campbell, Anna de Fazio, Stephen B. Fox, Judy Kirk, Geoffrey J. Lindeman, Roger L. Milne, Melissa C. Southey, Amanda B. Spurdle, Heather Thorne, Agnes Jager, Anna Jakubowska, Esther M. John, Nichola Johnson, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Renske Keeman, Э. К. Хуснутдинова, Cari M. Kitahara, Yon‐Dschun Ko, Veli‐Matti Kosma, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka‐Sabit, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Martha S. Linet, Alicja Ogrodniczak, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, Dimitrios Mavroudis, Roger L. Milne, Taru Muranen, Rachel A. Murphy, Heli Nevanlinna, Janet E. Olson, Håkan Olsson, Tjoung‐Won Park‐Simon, Charles M. Perou, Paolo Peterlongo, Dijana Plaseska‐Karanfilska, Katri Pylkäs, Gad Rennert, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Rana Shibli, Ann Smeets, Penny Soucy, Melissa C. Southey, Anthony J. Swerdlow, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Ian Tomlinson, Melissa A. Troester, Thérèse Truong, Celine M. Vachon, Camilla Wendt, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Argyrios Ziogas, Jacques Simard, Alison M. Dunning, Paul D.P. Pharoah, Douglas F. Easton,
Abstract Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 ( P = 3.7E−18). Nine other genes were associated with a p -value < 0.01 including known susceptibility ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Nature Portfolio | Communications Biology
Hermela Shimelis, Romy L.S. Mesman, Catharina Von Nicolai, Åsa Ehlén, Lucia Guidugli, Charlotte Martin, Fabienne M.G.R. Calléja, Huong Meeks, Emily Hallberg, Jamie Hinton, Jenna Lilyquist, Chunling Hu, Cora M. Aalfs, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Javier Benı́tez, Natalia Bogdanova, Stig E. Bojesen, Manjeet K. Bolla, Anne‐Lise Børresen‐Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Annegien Broeks, Barbara Brouwers, Thomas Brüning, Barbara Burwinkel, Jenny Chang‐Claude, Georgia Chenevix‐Trench, Ching‐Yu Cheng, Ji‐Yeob Choi, J. Margriet Collée, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Joe Dennis, Thilo Dörk, Isabel dos‐Santos‐Silva, Alison M. Dunning, Peter A. Fasching, Jonine D. Figueroa, Henrik Flyger, Montserrat García‐Closas, Graham G. Giles, Gord Glendon, Pascal Guénel, Christopher A. Haiman, Per Hall, Ute Hamann, Mikael Hartman, Frans B.L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Hidemi Ito, Anna Jakubowska, Daehee Kang, Veli‐Matti Kosma, Vessela N. Kristensen, Kah-Nyin Lai, Diether Lambrechts, Loı̈c Le Marchand, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubiński, Eva Macháčková, Graham J. Mann, Sara Margolin, Frederik Marmé, Keitaro Matsuo, Hui Miao, Kyriaki Michailidou, Roger L. Milne, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Janet E. Olson, Curtis Olswold, Jan J.C. Oosterwijk, Ana Osório, Paolo Peterlongo, Julian Peto, Paul D.P. Pharoah, Katri Pylkäs, Paolo Radice, Muhammad Usman Rashid, Valerie Rhenius, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Minouk J. Schoemaker, Caroline Seynaeve, Mitul Shah, Chen‐Yang Shen, Martha J. Shrubsole, Xiao‐Ou Shu, Susan Slager, Melissa C. Southey, Daniel O. Stram, Anthony J. Swerdlow, Soo‐Hwang Teo, Ian Tomlinson, Diana Torres, Thérèse Truong, Christi J. van Asperen, Lizet E. van der Kolk, Sophia Wang, Robert Winqvist, Anna H. Wu, Jyh‐Cherng Yu, Wei Zheng, Ying Zheng, Jennifer Leary, Logan C. Walker, Lenka Foretová, Florentia Fostira, Kathleen Claes, Liliana Varesco, Setareh Moghadasi, Douglas F. Easton, Amanda B. Spurdle, Peter Devilee, Harry Vrieling, Álvaro N.A. Monteiro, David E. Goldgar, Aura Carreira, Maaike P.G. Vreeswijk, Fergus J. Couch,
Breast cancer risks conferred by many germline missense variants in the
Tópico(s): Nutrition, Genetics, and Disease
2017 - American Association for Cancer Research | Cancer Research
Alison M. Dunning, Catherine S. Healey, Caroline Baynes, Ana-Teresa Maia, Serena Scollen, Ana Vega, Raquel Rodríguez, Nuno L. Barbosa‐Morais, Bruce A.J. Ponder, Yen-Ling Low, Sheila Bingham, Christopher A. Haiman, Loı̈c Le Marchand, Annegien Broeks, Marjanka K. Schmidt, John L. Hopper, Melissa C. Southey, Matthias W. Beckmann, Peter A. Fasching, Julian Peto, Nichola Johnson, Stig E. Bojesen, Børge G. Nordestgaard, Roger L. Milne, Javier Benı́tez, Ute Hamann, Yon Ko, Rita K. Schmutzler, Barbara Burwinkel, Peter Schürmann, Thilo Dörk, Tuomas Heikkinen, Heli Nevanlinna, Annika Lindblom, Sara Margolin, Graham J. Mann, Veli-Matti Kosma, Xiaohong Chen, Amanda B. Spurdle, Jenny Change-Claude, Dieter Flesch‐Janys, Fergus J. Couch, Janet E. Olson, Gianluca Severi, Laura Baglietto, Anne‐Lise Børresen‐Dale, Vessela Kristensen, David J. Hunter, Susan E. Hankinson, Peter Devilee, Maaike P.G. Vreeswijk, Jolanta Lissowska, Louise A. Brinton, Jianjun Liu, Per Hall, Daehee Kang, Keun-Young Yoo, Chen‐Yang Shen, Jyh-Cherng Yu, Hoda Anton‐Culver, Argyrios Ziogoas, Alice J. Sigurdson, Jeffery P. Struewing, Douglas F. Easton, Montserrat García‐Closas, Manjeet K. Humphreys, Jonathan J. Morrison, Paul D.P. Pharoah, Karen A. Pooley, Georgia Chenevix‐Trench,
We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55 000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carriers ...
Tópico(s): Nutrition, Genetics, and Disease
2009 - Oxford University Press | Human Molecular Genetics
Zhiguo Zhao, Wanqing Wen, Kyriaki Michailidou, Manjeet K. Bolla, Sophia Wang, Ben Zhang, Jirong Long, Xiao‐Ou Shu, Marjanka K. Schmidt, Roger L. Milne, Montserrat García‐Closas, Jenny Chang‐Claude, Sara Lindström, Stig E. Bojesen, Habibul Ahsan, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Alicia Beeghly‐Fadiel, Javier Benı́tez, Carl Blomqvist, Natalia Bogdanova, Anne‐Lise Børresen‐Dale, Judith S. Brand, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Qiuyin Cai, Graham Casey, Georgia Chenevix‐Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Thilo Dörk, Martine Dumont, Peter A. Fasching, Jonine D. Figueroa, Dieter Flesch‐Janys, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Marilie D. Gammon, Graham G. Giles, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Patricia Harrington, Mikael Hartman, Maartje J. Hooning, John L. Hopper, Anna Jakubowska, Farzana Jasmine, Esther M. John, Nichola Johnson, Maria Kabisch, Sofia Khan, Muhammad G. Kibriya, Julia A. Knight, Veli‐Matti Kosma, Mieke Kriege, Vessela Kristensen, Loı̈c Le Marchand, Eunjung Lee, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Robert Luben, Jan Lubiński, Kathleen E. Malone, Graham J. Mann, Siranoush Manoukian, Sara Margolin, Frederik Marmé, Catriona McLean, Hanne Meijers‐Heijboer, Alfons Meindl, Hui Miao, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Patrick Neven, Janet E. Olson, Barbara Perkins, Paolo Peterlongo, Kelly‐Anne Phillips, Katri Pylkäs, Anja Rudolph, Regina M. Santella, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Mitul Shah, Martha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Amanda E. Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Giske Ursin, Rob B. van der Luijt, Senno Verhoef, Shan Wang‐Gohrke, Alice S. Whittemore, Robert Winqvist, M. Pilar Zamora, Hui Zhao, Alison M. Dunning, Jacques Simard, Per Hall, Peter Kraft, Paul D.P. Pharoah, David J. Hunter, Douglas F. Easton, Wei Zheng,
Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were ...
Tópico(s): BRCA gene mutations in cancer
2016 - Springer Science+Business Media | Cancer Causes & Control
Peter R. Monge, Seungyoon Lee, Janet Fulk, Matthew S. Weber, Cuihua Shen, Courtney M. Schultz, Drew Margolin, Jessica Janine Gould, Lauren B. Frank,
In a previous MCQ article, Monge et al. overviewed the fundamental concepts and processes of evolutionary theory and their applications to key issues in organizational communication. This article extends that work by providing an overview of research tools for studying organizational ecology and evolution, including (a) the variation-selection-retention sequence, (b) the likelihood of events occurring over a period of time (event history analysis), (c) transition sequence of populations from one state ...
Tópico(s): Business Strategy and Innovation
2011 - SAGE Publishing | Management Communication Quarterly
Jiajun Shi, Yanfeng Zhang, Wei Zheng, Kyriaki Michailidou, Maya Ghoussaini, Manjeet K. Bolla, Sophia Wang, Joe Dennis, Michael Lush, Roger L. Milne, Xiao‐Ou Shu, Jonathan Beesley, Siddhartha Kar, Irene L. Andrulis, Hoda Anton‐Culver, Volker Arndt, Matthias W. Beckmann, Zhiguo Zhao, Xingyi Guo, Javier Benı́tez, Alicia Beeghly‐Fadiel, William J. Blot, Natalia Bogdanova, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Louise A. Brinton, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Hui Cai, Sander Canisius, Jenny Chang‐Claude, Ji‐Yeob Choi, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Hatef Darabi, Peter Devilee, Arnaud Droit, Thilo Dörk, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Valérie Gaborieau, Montserrat García‐Closas, Graham G. Giles, Mervi Grip, Pascal Guénel, Christopher A. Haiman, Ute Hamann, Mikael Hartman, Hui Miao, Antoinette Hollestelle, John L. Hopper, Chia‐Ni Hsiung, Hidemi Ito, Anna Jakubowska, Nichola Johnson, Diana Torres, Maria Kabisch, Daehee Kang, Sofia Khan, Julia A. Knight, Veli‐Matti Kosma, Diether Lambrechts, Jingmei Li, Annika Lindblom, Artitaya Lophatananon, Jan Lubiński, Arto Mannermaa, Siranoush Manoukian, Loı̈c Le Marchand, Sara Margolin, Frederik Marmé, Keitaro Matsuo, Catriona McLean, Thomas Ind, Kenneth Muir, Susan L. Neuhausen, Heli Nevanlinna, Silje Nord, Anne‐Lise Børresen‐Dale, Janet E. Olson, Nick Orr, Ans M.W. van den Ouweland, Paolo Peterlongo, Thomas Choudary Putti, Anja Rudolph, Suleeporn Sangrajrang, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Chen‐Yang Shen, Ming‐Feng Hou, Matha J. Shrubsole, Melissa C. Southey, Anthony J. Swerdlow, Soo‐Hwang Teo, Bernard Thienpont, Amanda E. Toland, Robert A.E.M. Tollenaar, Ian Tomlinson, Thérèse Truong, Chiu-Chen Tseng, Wanqing Wen, Robert Winqvist, Anna H. Wu, Cheng Har Yip, Pilar Zamora, Ying Zheng, Giuseppe Floris, Ching‐Yu Cheng, Maartje J. Hooning, John W.M. Martens, Caroline Seynaeve, Vessela N. Kristensen, Per Hall, Paul D.P. Pharoah, Jacques Simard, Georgia Chenevix‐Trench, Alison M. Dunning, Antonis C. Antoniou, Douglas F. Easton, Qiuyin Cai, Jirong Long,
Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented ...
Tópico(s): Genomics and Chromatin Dynamics
2016 - Wiley | International Journal of Cancer