Produção Nacional
Revisado por pares
Jaqueline Carvalho de Oliveira, Carlos Alberto Scrideli, María Sol Brassesco, José Andres Yunes, Sílvia Regina Brandalise, Luíz Gonzaga Tone,
... leukemia but not strongly associated to clinical features Jaqueline Carvalho de Oliveira PhD, Corresponding Author Jaqueline Carvalho de Oliveira PhD Institute of Natural Sciences, Federal University of Alfenas, Minas Gerais, Brazil Correspondence to: Jaqueline Carvalho de Oliveira, Institute of Natural Sciences, Federal University ... Paulo, BrazilSearch for more papers by this author Jaqueline Carvalho de Oliveira PhD, Corresponding Author Jaqueline Carvalho de Oliveira PhD Institute of Natural Sciences, Federal ...
Tópico(s): RNA modifications and cancer
2014 - Wiley | Pediatric Blood & Cancer
Produção Nacional
A. J. F. de Almeida, Jaqueline Carvalho e Silva Sales, Marie-Aude Maynard, T. Lauprêtre, Fabien Bretenaker, D. Felinto, Fabienne Goldfarb, J. W. R. Tabosa,
We report on the storage of light via the phenomenon of Coherent Population Oscillation (CPO) in an atomic cesium vapor at room temperature. In the experiment the optical information of a probe field is stored in the CPO of two ground states of a Lambda three-level system formed by the Zeeman sublevels of the hyperfine transition F = 3 - F' = 2 of cesium D2 line. We show directly that this CPO based memory is very insensitive to stray magnetic field inhomogeneities and presents a lifetime which is mainly ...
Tópico(s): Cold Atom Physics and Bose-Einstein Condensates
2014 - American Physical Society | Physical Review A
Produção Nacional
Revisado por pares
María Sol Brassesco, Julia Alejandra Pezuk, Andressa Gois Morales, Jaqueline Carvalho de Oliveira, Gabriela Molinari Roberto, Glenda Nicioli da Silva, Harley Francisco de Oliveira, Carlos Alberto Scrideli, Luíz Gonzaga Tone,
Despite the improvements in neoadjuvant chemotherapy, the outcome of patients with advanced bladder cancer has changed very little over the past 30 years. In the present study we tested and compared the in vitro antitumor activities of four different inhibitors of Polo-like kinase 1 (PLK1) (BI 2536, BI 6727, GW843682X, and GSK461364), against 3 bladder carcinoma cell lines RT4, 5637 and T24. The impact on radiosensitivity and drug interactions in simultaneous treatments with cisplatin, methotrexate, ...
Tópico(s): Epigenetics and DNA Methylation
2013 - Taylor & Francis | Cancer Biology & Therapy
Produção Nacional
Revisado por pares
Julia Alejandra Pezuk, María Sol Brassesco, Andressa Gois Morales, Jaqueline Carvalho de Oliveira, Rosane Gomes de Paula Queiróz, Hélio Rubens Machado, Carlos Gilberto Carlotti, Luciano Neder, Carlos Alberto Scrideli, Luíz Gonzaga Tone,
Glioblastoma (GBM) is one of the most aggressive central nervous system tumors with a patient's median survival of <1 year. Polo-like kinases (PLKs) are a family of serine/threonine kinases that have key roles in cell cycle control and DNA-damage response. We evaluated PLK1, 2, 3 and 4 gene expression in 8 GBM cell lines and 17 tumor samples, and analyzed the effect of the PLK1 inhibition on SF188 and T98G GBM cell lines and 13 primary cultures. Our data showed PLK1 overexpression and a variable altered ...
Tópico(s): Cancer-related Molecular Pathways
2013 - Springer Nature | Cancer Gene Therapy
Produção Nacional
Revisado por pares
María Sol Brassesco, Gabriela Molinari Roberto, Andressa Gois Morales, Jaqueline Carvalho de Oliveira, Lara Elis Alberici Delsin, Julia Alejandra Pezuk, Elvis Terci Valera, Carlos Gilberto Carlotti, Eduardo Magalhães Rego, Harley Francisco de Oliveira, Carlos Alberto Scrideli, Kazuo Umezawa, Luíz Gonzaga Tone,
Despite advances in neurosurgery and aggressive treatment with temozolomide (TMZ) and radiation, the overall survival of patients with glioblastoma (GBM) remains poor. Vast evidence has indicated that the nuclear factor NF- κ B is constitutively activated in cancer cells, playing key roles in growth and survival. Recently, Dehydroxymethylepoxyquinomicin (DHMEQ) has shown to be a selective NF- κ B inhibitor with antiproliferative properties in GBM. In the present study, the ability of DHMEQ to surmount ...
Tópico(s): Natural Compounds in Disease Treatment
2013 - Hindawi Publishing Corporation | Chemotherapy Research and Practice
Produção Nacional
Revisado por pares
Julia Alejandra Pezuk, María Sol Brassesco, Andressa Gois Morales, Jaqueline Carvalho de Oliveira, Harley Francisco de Oliveira, Carlos Alberto Scrideli, Luíz Gonzaga Tone,
Despite efforts to improve surgical, radiologic, and chemotherapeutic strategies, the outcome of patients with glioblastoma (GBM) is still poor. Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays key roles in cell cycle control and has been associated with tumor growth and prognosis. Here, we aimed at testing the radiosensitizing effects of the PLK1 inhibitor BI 2536 on eight GBM cell lines. For cell cycle analysis, T98G, U251, U343 MG-a, LN319, SF188, U138 MG, and U87 MG cell lines ...
Tópico(s): Cancer Genomics and Diagnostics
2013 - Mary Ann Liebert, Inc. | Cancer Biotherapy and Radiopharmaceuticals
Andressa Gois Morales, Julia Alejandra Pezuk, María Sol Brassesco, Jaqueline Carvalho de Oliveira, Rosane Gomes de Paula Queiróz, Hélio Rubens Machado, Carlos Gilberto Carlotti, Luciano Neder, Harley Francisco de Oliveira, Carlos Alberto Scrideli, Luíz Gonzaga Tone,
Tópico(s): Protist diversity and phylogeny
2013 - Springer Science+Business Media | Child s Nervous System
Produção Nacional
Revisado por pares
Augusto Faria Andrade, Kleiton Silva Borges, Angel Mauricio Castro‐Gamero, Vanessa S. Silveira, V.K. Suazo, Jaqueline Carvalho de Oliveira, Daniel Antunes Moreno, Rosane Gomes de Paula Queiróz, Carlos Alberto Scrideli, Luíz Gonzaga Tone,
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in childhood. Despite the advances in treatment, about 20% of patients relapse and/or die, indicating the need for different therapies for this group. Zebularine (ZB) is a potent DNA methyltransferase (DNMT) inhibitor and has been associated with gene demethylation and enhancement of tumor chemosensitivity. This study aimed to evaluate the effects of ZB, alone or combined with chemotherapeutics (methotrexate and vincristine), ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
2013 - Lippincott Williams & Wilkins | Anti-Cancer Drugs
Produção Nacional
Dayse Layanne Pereira Meneses, Fernando José Guedes da Silva Júnior, Hayanna De Sousa Ferreira Melo, Jaqueline Carvalho e Silva, Vera Lúcia Evangelista de Sousa Luz, Maria do Livramento Fortes Figueiredo,
O crescimento da população idosa no Brasil aponta demandas para o autocuidado. Objetivou-se com este estudo descrever e analisar o significado da velhice para 12 idosos de ambos os sexos, cadastrados em um Centro de Convivência no município de Teresina-PI. Os dados foram coletados por meio de entrevistas abertas, gravadas e transcritas na íntegra. A análise temática possibilitou a formulação de duas categorias: a velhice como sinônimo de felicidade, união familiar e experiência de vida; bem como ...
Tópico(s): Health, Nursing, Elderly Care
2013 - | Enfermagem em Foco
Produção Nacional
Revisado por pares
José Eduardo Baroneza, Maria José Sparça Salles de Faria, Hellen Kuasne, Juliana Laino do Val Carneiro, Jaqueline Carvalho de Oliveira,
The aim of the present study was to describe the characteristics of 377 cleft patients assisted by an institution of Londrina, State of Paraná. For that purpose, the prevalence of the clefts in relation to gender, pregnancy maternal smoke habits until the third month, cleft family history, families’ social level, and parents’ ages when cleft bearer was conceived were evaluated. The highest prevalence was observed for cleft lip and palate (59.9%) the ratio between genders was 1.5 male: 1.0 female ...
Tópico(s): Congenital Anomalies and Fetal Surgery
2005 - UNIVERSIDADE ESTADUAL DE MARINGÁ | Acta Scientiarum Health Sciences
Produção Nacional
Revisado por pares
Douglas Adamóski, Valter A. Baura, Ana Carolina Rodrigues, Carla Adriane Royer, Mateus Nóbrega Aoki, Marcel Kruchelski Tschá, Ana Cláudia Bonatto, Roseli Wassem, Meri Bordignon Nogueira, Sônia Mara Raboni, Bernardo Montesanti Machado de Almeida, Edvaldo da Silva Trindade, Daniela Fiori Gradia, Emanuel Maltempi de Souza, Jaqueline Carvalho de Oliveira,
Screening efforts and genomic surveillance are essential tools to evaluate the course of the COVID-19 pandemic and assist the public healthcare system in dealing with an increasing number of infections. For the analysis of COVID-19 cases scenarios in Curitiba, Paraná, Brazil, we performed a diagnosis of positive cases, coupled with genotyping, for symptomatic and asymptomatic members of the Federal University of Paraná. We achieved over 1000 samples using RT-qPCR for diagnosis. The posterior genotyping ...
Tópico(s): COVID-19 and Mental Health
2022 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Carolina Mathias, João C. D. Muzzi, Bruna Borba Antunes, Daniela Fiori Gradia, Mauro A. A. Castro, Jaqueline Carvalho de Oliveira,
Breast cancer (BRCA) is the most leading cause of cancer worldwide. It is a heterogeneous disease with at least five molecular subtypes including luminal A, luminal B, basal-like, HER2-enriched, and normal-like. These five molecular subtypes are usually stratified according to their mRNA profile patterns; however, ncRNAs are increasingly being used for this purpose. Among the ncRNAs class, the long non-coding RNAs (lncRNAs) are molecules with more than 200 nucleotides with versatile regulatory roles; ...
Tópico(s): RNA Research and Splicing
2021 - Frontiers Media | Frontiers in Oncology
Produção Nacional
Revisado por pares
Ana Carolina Rodrigues, Douglas Adamóski, Gustavo Genelhould, Felipe Zhen, Guilherme Eiji Yamaguto, Patrícia Savio de Araújo-Souza, Meri Bordignon Nogueira, Sônia Mara Raboni, Ana Cláudia Bonatto, Daniela Fiori Gradia, Jaqueline Carvalho de Oliveira,
COVID-19, caused by the SARS-CoV-2 virus, has become a significant global public health problem, with a wide variety of clinical manifestations and disease progression outcomes. LncRNAs are key regulators of the immune response and have been associated with COVID-19 risk infection. Previous studies focused mainly on in-silico analysis of lncRNA expression in the lungs or peripheral blood cells. We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from ...
Tópico(s): MicroRNA in disease regulation
2021 - Wiley | Molecular Oral Microbiology
Produção Nacional
Revisado por pares
Juliana Mara Serpeloni, Quirino Alves de Lima Neto, Léia Carolina Lúcio, Anelisa Ramão, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia, Danielle Malheiros, Adriano Ferrasa, Rafael Marchi, David Livingstone Alves Figueiredo, Wilson A. Silva, Enilze M.S.F. Ribeiro, I.M.S. Cólus, Luciane R. Cavalli,
In this review, we highlight the interaction of SARS-CoV-2 virus and host genomes, reporting the current studies on the sequence analysis of SARS-CoV-2 isolates and host genomes from diverse world populations. The main genetic variants that are present in both the virus and host genomes were particularly focused on the ACE2 and TMPRSS2 genes, and their impact on the patients' susceptibility to the virus infection and severity of the disease. Finally, the interaction of the virus and host non-coding ...
Tópico(s): Animal Virus Infections Studies
2021 - Elsevier BV | Immunobiology
Produção Nacional
Revisado por pares
Rafaela Nasser Veiga, Jaqueline Carvalho de Oliveira, Daniela Fiori Gradia,
Tópico(s): Cancer-related gene regulation
2021 - Springer Science+Business Media | Journal of Molecular Medicine
Produção Nacional
Revisado por pares
Beatriz Marques Assad, Daiani Cristina Savi, Stellee Marcela Petris Biscaia, Bárbara Fanaya Mayrhofer, Jucélia Iantas, Mathias Mews, Jaqueline Carvalho de Oliveira, Edvaldo da Silva Trindade, Chirlei Glienke,
The increase in the number of deaths from infections caused by multidrug-resistant bacteria and cancer diseases highlights the need for new molecules with biological activity. Actinobacteria represent a potential source of new compounds, as these microorganisms have already produced a great diversity of clinically employed antibiotics. Endophytes from unexplored biomes, such as the Pantanal (the largest wetland in the world), can be a source of new molecules. Hymenachne amplexicaulis is among the ...
Tópico(s): Alkaloids: synthesis and pharmacology
2021 - Elsevier BV | Microbiological Research
Produção Nacional
Revisado por pares
Fernando José Guedes da Silva Júnior, Jaqueline Carvalho e Silva Sales, Claudete Ferreira de Souza Monteiro, Ana Paula Cardoso Costa, Luana Ruth Braga Campos, Priscilla Ingrid Gomes Miranda, Thiago Alberto de Souza Monteiro, Regina Aparecida Garcia de Lima, Luís Carlos Lopes-Júnior,
Since the WHO declared COVID-19 as a pandemic, the spread of the new coronavirus has been the focus of attention of scientists, governments and populations. One of the main concerns is the impact of this pandemic on health outcomes, mainly on mental health. Even though there are a few empirical studies on COVID-19 and mental health, so far, there is no systematic review about the impact of COVID-19 on mental health of young people and adults yet. We aim to critically synthesise the scientific evidence ...
Tópico(s): Mental Health Research Topics
2020 - BMJ | BMJ Open
Produção Nacional
Eukália Pereira da Rocha, Claudete Ferreira de Souza Monteiro, Jaqueline Carvalho e Silva Sales, Lorena Uchôa Portela Veloso, Fernando José Guedes da Silva Júnior, Thiago Alberto de Souza Monteiro,
Objetivo: Analisar o padrão de consumo do álcool e fatores associados em mulheres. Método: Estudo transversal, com 305 mulheres na faixa de 20 a 59 anos, atendidas em unidades básicas de saúde em Teresina/Piauí/Brasil. Utilizou-se Escala Alcohol Use Desorders Identification Test para identificar o padrão de consumo do álcool e questionário para variáveis sociodemográficas, de saúde e hábitos de vida, com coleta de maio a junho de 2019 e analisados pelo software Statistical Package for the Social ...
Tópico(s): Youth, Drugs, and Violence
2020 - | Revista Enfermagem Atual In Derme
Produção Nacional
Revisado por pares
Pablo Shimaoka Chagas, Graziella Ribeiro de Sousa, Márcio Hideki Kodama, Carlos Alberto Oliveira de Biagi, José Andres Yunes, Sílvia Regina Brandalise, George A. Calin, Luíz Gonzaga Tone, Carlos Alberto Scrideli, Jaqueline Carvalho de Oliveira,
Aberrant expression of long non-coding RNAs (lncRNAs) has been detected in several types of cancer, including acute lymphoblastic leukemia (ALL), but lncRNA mapped on transcribed ultraconserved regions (T-UCRs) are little explored. The T-UCRs uc.112, uc.122, uc.160 and uc.262 were evaluated by quantitative real-time PCR in bone marrow samples from children with T-ALL (n = 32) and common-ALL/pre-B ALL (n = 30). In pediatric ALL, higher expression levels of uc.112 were found in patients with T-ALL, compared ...
Tópico(s): Acute Lymphoblastic Leukemia research
2020 - Elsevier BV | Hematology Transfusion and Cell Therapy
Produção Nacional
Revisado por pares
Carolina Mathias, Érika Pereira Zambalde, Philip Rask, Daniela Fiori Gradia, Jaqueline Carvalho de Oliveira,
Breast Cancer (BC) is the most commonly diagnosed cancer and is the leading cause of cancer deaths in women. BC is a heterogeneous disease with different clinical and genetic features. According to immunohistochemical markers, BC is subdivided into four main subtypes: luminal A, luminal B, ERBB2 positive and triple negative. Long non‐coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides and deregulated lncRNAs are associated with human diseases, including BC. In order to improve BC ...
Tópico(s): Circular RNAs in diseases
2019 - Wiley | Clinical Genetics
Produção Nacional
Jaqueline Carvalho e Silva Sales, Camilla de Oliveira Castelo Branco, Jordana Fonseca Reis, Polyana Norberta Mendes, Fernando José Guedes da Silva Júnior, Andréia Rodrigues Moura da Costa Valle,
ABSTRACT Objective: To analyze the physician’s and nurse’s perceptions about the actions developed by the Family Health Support Center (FHSC). Method: A qualitative study, conducted with 16 physicians and 23 nurses. Data was collected through interviews and submitted to thematic analysis. Results: Three categories emerged: The actions developed by the Family Health Support Center were positively perceived by Family Health Strategy (FHS) professionals; Tools that favor the integrality of the actions ...
Tópico(s): Male Reproductive Health Studies
2019 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Escola Anna Nery
Produção Nacional
Revisado por pares
Érika Pereira Zambalde, Carolina Mathias, Ana Carolina Rodrigues, Enilze Maria de Souza Fonseca Ribeiro, Daniela Fiori Gradia, George A. Călin, Jaqueline Carvalho de Oliveira,
Abstract Ultraconserved regions (UCRs) are 481 DNA segments longer than 200 bp in length that are completely conserved among human, mouse, and rat and, extremely conserved across disparate taxa. More than 90% of UCRs are transcribed (T‐UCRs) in normal tissues, but most of them remain uncharacterized. In addition, it was demonstrated that T‐UCRs have a tissue‐specific expression, and a differential expression profile between tumors and other diseases, which suggests that most of T‐UCRs may have an ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Wiley | Wiley Interdisciplinary Reviews - RNA
Produção Nacional
Revisado por pares
Lorena Uchôa Portela Veloso, Camylla Layanny Soares Lima, Jaqueline Carvalho e Silva Sales, Claudete Ferreira de Souza Monteiro, Angélica Martins de Souza Gonçalves, Fernando José Guedes da Silva Júnior,
To identify the prevalence of suicidal ideation and its associated factors in university students from the health field, in a public higher education institution.Cross-sectional study with 142 university students. Suicide Ideation Scale and a questionnaire for characterization were used. Fischer's exact test, chi-square, Odds-Ratio, Kruskal-Wallis, and Spearman's correlation were performed. A significance level of 0.05 was adopted.The prevalence of suicidal ideation was 22%. It was associated to ...
Tópico(s): Occupational Health and Burnout
2019 - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL | Revista gaúcha de enfermagem
Produção Nacional
Revisado por pares
Maria do Socorro Ribeiro de Araújo Sarmento, Jaqueline Carvalho e Silva Sales, Fernando José Guedes da Silva Júnior, Adriana da Cunha Meneses Parente,
Objetivou-se descrever o comportamento sexual e o uso de métodos contraceptivos por universitárias da área da saúde em uma instituição de ensino superior público. Trata-se de estudo transversal desenvolvido com 177 estudantes dos cursos de Educação Física, Enfermagem, Farmácia, Medicina, Nutrição e Odontologia. Utilizou-se questionário composto por questões fechadas. Os dados foram dispostos para análise mediante a utilização do software Statistical Package for the Social Science, versão 19.0. Foram ...
Tópico(s): Gender Roles and Identity Studies
2018 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Reme Revista Mineira de Enfermagem
Produção Nacional
Revisado por pares
Gabriel Adelman Cipolla, Jaqueline Carvalho de Oliveira, Amanda Salviano‐Silva, Sara Cristina Lobo‐Alves, Débora S. Lemos, Luana Ramos de Oliveira, Tayana Shultz Jucoski, Carolina Mathias, Gabrielle Araújo Pedroso, Érika Pereira Zambalde, Daniela Fiori Gradia,
Multifactorial diseases such as cancer, cardiovascular conditions and neurological, immunological and metabolic disorders are a group of diseases caused by the combination of genetic and environmental factors. High-throughput RNA sequencing (RNA-seq) technologies have revealed that less than 2% of the genome corresponds to protein-coding genes, although most of the human genome is transcribed. The other transcripts include a large variety of non-coding RNAs (ncRNAs), and the continuous generation ...
Tópico(s): RNA modifications and cancer
2018 - Multidisciplinary Digital Publishing Institute | Non-Coding RNA
Produção Nacional
Revisado por pares
Jaqueline Carvalho de Oliveira, Luana Caroline Oliveira, Carolina Mathias, Gabrielle Araújo Pedroso, Débora S. Lemos, Amanda Salviano‐Silva, Tayana Schultz Jucoski, Sara Cristina Lobo‐Alves, Érika Pereira Zambalde, Gabriel Adelman Cipolla, Daniela Fiori Gradia,
We review the most well characterized long non-coding RNAs (lncRNAs) with important roles in hallmarks of cancer, additionally including lncRNAs with a higher potential for clinical application. LncRNAs are transcripts larger than 200 nucleotides in length that do not appear to have protein-coding potential, although some of those may produce small functional peptides. These transcripts have attracted significant attention from researchers as a result of their role in genetic regulation, including ...
Tópico(s): RNA modifications and cancer
2018 - Wiley | The Journal of Gene Medicine
Produção Nacional
Revisado por pares
Wanderson Santana Fraga, Valquíria M Seixas, Jaqueline Carvalho dos Santos, Luiz Renato Paranhos, Carla Patrícia Hernandez Alves Ribeiro César,
Mouth breathing in childhood can compromise the dental occlusion and, consequently, the functions performed by the stomatognathic system. The purpose of this systematic review was to evaluate which is the highest prevalence of dental malocclusion in mouth breathing children.Bibliographic searches of observational studies were performed in five electronic databases (PubMed, LILACS, SciELO, Scopus and Open Grey) without language restriction, from 2007 to 2014. Were selected cross-sectional or longitudinal ...
Tópico(s): Dental Radiography and Imaging
2018 - | Minerva Dental and Oral Science
Produção Nacional
Revisado por pares
Jaqueline Carvalho de Oliveira, Gabriela Molinari Roberto, Mirella Baroni, Karina Bezerra Salomão, Julia Alejandra Pezuk, María Sol Brassesco,
For decades, cancer biology focused largely on the protein-encoding genes that have clear roles in tumor development or progression: cell-cycle control, apoptotic evasion, genome instability, drug resistance, or signaling pathways that stimulate growth, angiogenesis, or metastasis. MicroRNAs (miRNAs), however, represent one of the more abundant classes of cell modulators in multicellular organisms and largely contribute to regulating gene expression. Many of the ~2500 miRNAs discovered to date in ...
Tópico(s): RNA modifications and cancer
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Jaqueline Carvalho de Oliveira, Poliana Figueiredo, Galileu Barbosa Costa, Felipe Lopes de Assis, Betânia Paiva Drumond, Flávio Guimarães da Fonseca, Maurício Lacerda Nogueira, Erna Geessien Kroon, Giliane S. Trindade,
The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remain unknown. VACV was the primary component of the smallpox vaccine, largely used during the smallpox eradication campaign. After smallpox was declared eradicated, the vaccination that conferred ...
Tópico(s): Rabies epidemiology and control
2017 - Multidisciplinary Digital Publishing Institute | Viruses
Produção Nacional
Revisado por pares
Daniela Fiori Gradia, Carolina Mathias, R.A. Coutinho, Iglenir João Cavalli, Enilze M.S.F. Ribeiro, Jaqueline Carvalho de Oliveira,
Taurine upregulated 1 gene (TUG1) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features. Although this is evidence of a potential role in breast cancer, TUG1 expression could not be associated with different subtypes, possibly due to the small number of samples analyzed. Breast cancer is a heterogeneous disease and, based on molecular signatures, may be ...
Tópico(s): MicroRNA in disease regulation
2017 - Multidisciplinary Digital Publishing Institute | Non-Coding RNA