Produção Nacional
Revisado por pares
Luciano da Silva Momesso, Rute Mendonça Xavier de Moura, Dulce Helena Jardim Constantino,
O Ageratum conyzoides, vegetal conhecido popularmente no Brasil é constituído por várias substâncias químicas, dentre elas os flavonóides, aos quais já foi atribuída a atividade antitumoral. Neste estudo foi avaliado o efeito das frações clorofórmica e metanólica do extrato AcOEt das folhas sobre o crescimento do tumor de Ehrlich. Foi constatado que o tratamento com as frações metanólicas, nas doses de 50 mg/kg de peso foi eficaz, inibindo o crescimento tumoral. A porcentagem de inibição para a ...
Tópico(s): Sesquiterpenes and Asteraceae Studies
2009 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Helena Jardim, V Shah, J.M. Savage, T M Barratt, Michael J. Dillon,
As there is a 10% risk of hypertension developing in children with reflux nephropathy and the renin-angiotensin system has been implicated in its aetiology, a long term prospective study has been undertaken to explore the relationship between plasma renin activity (PRA) and blood pressure in such patients. In 1978, of 100 normotensive children with reflux nephropathy 8% were shown to have PRA above normal. Five years later of 85 subjects suitable for analysis 13% had increased PRA and it was shown ...
Tópico(s): Renal and Vascular Pathologies
1991 - BMJ | Archives of Disease in Childhood
Helena Jardim, Janet Leake, R. A. Risdon, T M Barratt, Michael J. Dillon,
Tópico(s): Inflammasome and immune disorders
1992 - Springer Science+Business Media | Pediatric Nephrology
Beata S. Lipska‐Ziętkiewicz, Paraskevas Iatropoulos, Ramona Maranta, Gianluca Caridi, Fatih Özaltın, Ali Anarat, Ayşe Balat, Jutta Gellermann, Agnes Trautmann, Özlem Erdoğan, Bassam Saeed, Sevinç Emre, Radovan Bogdanović, Marta Azócar, Irena Bałasz–Chmielewska, Elisa Benetti, Salim Çalışkan, Sevgı Mır, Anette Melk, Pelin Ertan, Esra Baskın, Helena Jardim, Tinatin Davitaia, Anna Wasilewska, Dorota Drożdż, Maria Szczepańska, Augustina Jankauskienė, Lina María Serna-Higuita, Gianluigi Ardissino, Ozan Özkaya, Elżbieta Kuźma-Mroczkowska, Oğuz Söylemezoğlu, Bruno Ranchin, Anna Medyńska, Marcin Tkaczyk, Amira Peco‐Antić, İpek Akil, Tomasz Jarmoliński, Piotr Adamczyk, Ladislav Dušek, Giacomo D. Simonetti, Faysal Gök, Alaleh Gheissari, Francesco Emma, Rafael T. Krmar, Michel Fischbach, Nikoleta Printza, Eva Šimková, Caterina Mele, Gian Marco Ghiggeri, Franz Schaefer,
Genetic screening paradigms for congenital and infantile nephrotic syndrome are well established; however, screening in adolescents has received only minor attention. To help rectify this, we analyzed an unselected adolescent cohort of the international PodoNet registry to develop a rational screening approach based on 227 patients with nonsyndromic steroid-resistant nephrotic syndrome aged 10–20 years. Of these, 21% had a positive family history. Autosomal dominant cases were screened for WT1, ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2013 - Elsevier BV | Kidney International
Manuel Pestana, Helena Jardim, Flora Correia, Maria Augusta Vieira‐Coelho, Patrício Soares‐da‐Silva,
The present report addresses the status of the renal dopaminergic system activity in patients afflicted with different renal disorders and in the remnant kidney of uninephrectomized (UNX) rats, based on the urinary excretion of l‐DOPA, dopamine and amine metabolites. In renal transplant recipients with good recovery of graft function (group 1, n=11), the daily urinary excretion of DOPAC, but not that of HVA, was found to increase progressively throughout the first 12 days post‐transplantation from ...
Tópico(s): Renal and Vascular Pathologies
2001 - Oxford University Press | Nephrology Dialysis Transplantation
António Guerra, Cristina P. Monteiro, Luiza Breitenfeld, Helena Jardim, Carla Rêgo, D Silva, Ana Rita Prata, José A. O. Matos, Altamiro Costa‐Pereira, Natacha Santos, Manuel Bicho,
Objectives: Blood pressure (BP) regulation depends on the interaction between multiple environmental and genetic factors. Of these, BP sensitivity to dietary sodium intake has been one that has been investigated in adults but not in children. The aim of the present study was to investigate, prospectively, the BP profile in relation to different genetic and hormonal factors, in the first 3 years of life. Population and methods: Thirty-nine children born at term following normal pregnancies, with uncomplicated ...
Tópico(s): Neuroscience of respiration and sleep
1997 - Springer Nature | Journal of Human Hypertension
Manuel Pestana, Helena Jardim, Paula Serrão, Patrício Soares‐da‐Silva, L. Guerra,
<b>Background: </b>Chronic renal parenchymal diseases are accompanied by a progressive loss of tubular units endowed with the ability to synthesise dopamine from <i>L</i>-3,4-dihydroxyphenylalanine (<i>L</i>-DOPA), and preliminary evidence has suggested that the urinary excretion of free dopamine may be reduced in these disorders. However, it is well recognised now that under in vitro conditions, dopamine newly synthesised in tubular epithelial cells undergoes extensive deamination ...
Tópico(s): Chronic Kidney Disease and Diabetes
1998 - Karger Publishers | Kidney & Blood Pressure Research
Produção Nacional
Revisado por pares
Luanna Munhoz Zabaglia, Mayara Luciana Sallas, Mônica Pezenatto dos Santos, Wilson Aparecido Orcini, Rita Luiza Peruquetti, Dulce Helena Jardim Constantino, Elizabeth Chen, Marı́lia de Arruda Cardoso Smith, Spencer-Luiz Payão, Lucas Trevizani Rasmussen,
Abstract miRNAs appear to play an important role in controlling the expression of several genes, and they are a potential biomarker and prognostic tool in gastric diseases. We analyzed 53 controls, 86 patients with gastritis, and 19 patients with gastric cancer. Real‐time‐PCR was used to determine the expression levels of miRNA‐146a, miRNA‐155, IL‐2, and TNF‐α. The subsequent analysis of the target genes was performed using the bioinformatics approach. There was no difference in IL‐2 expression ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Wiley | Annals of Human Genetics
Agnes Trautmann, Sven Schnaidt, Beata S. Lipska‐Ziętkiewicz, Monica Bodria, Fatih Özaltın, Francesco Emma, Ali Anarat, Anette Melk, Marta Azócar, Jun Oh, Bassam Saeed, Alaleh Gheisari, Salim Çalışkan, Jutta Gellermann, Lina María Serna-Higuita, Augustina Jankauskienė, Dorota Drożdż, Sevgı Mır, Ayşe Balat, Maria Szczepańska, Dušan Paripović, Aleksandra Żurowska, Radovan Bogdanović, Alev Yılmaz, Bruno Ranchin, Esra Baskın, Özlem Erdoğan, Giuseppe Remuzzi, Piotr Adamczyk, Elżbieta Kuźma-Mroczkowska, Mieczysław Litwin, Luisa Murer, Marcin Tkaczyk, Helena Jardim, Anna Wasilewska, Nikoleta Printza, Kibriya Fidan, Eva Šimková, Halina Borzęcka, Hagen Staude, Katharina Hees, Franz Schaefer,
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome in children with primary steroid-resistant nephrotic syndrome. From the PodoNet Registry, we obtained longitudinal clinical information for 1354 patients (disease onset at >3 months and <20 years of age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 had kidney biopsy results, and 212 had an established genetic diagnosis. We assessed risk ...
Tópico(s): Chronic Kidney Disease and Diabetes
2017 - American Society of Nephrology | Journal of the American Society of Nephrology
Produção Nacional
Revisado por pares
Cláudia Cristina Biguetti, André Hergesel de Oliva, Kent Healy, Ramez Hassan Mahmoud, Isabela Do Carmo Custódio, Dulce Helena Jardim Constantino, Edílson Ervolino, Marco Antônio Húngaro Duarte, Walid D. Fakhouri, Mariza Akemi Matsumoto,
Treatment with cumulative dosages of zoledronic acid (ZA) in elderly patients is a risk factor for the development of medication-related osteonecrosis of the jaws (MRONJ), mainly related to surgical triggers such as tooth extraction. However, animal models for the investigation and understanding of MRONJ pathophysiology in senescent and postmenopausal stages remains to be developed and characterized. The aim of this study was to analyze MRONJ development in senescent female mice treated with cumulative ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2019 - Public Library of Science | PLoS ONE
Catarina Tomás, Emanuel Oliveira, DANIEL WALLACE ASSIS DE SOUSA, Matheus Uba Chupel, Guilherme Eustáquio Furtado, Clara Rocha, Ana Teixeira, Pedro Lopes Ferreira, C. Alves, Stefan Gisin, Elisabete Catarino, Nelma Carvalho, Tiago Coucelo, Luís Américo Silva Bonfim, Carina Silva, Débora Franco, Jesús Alcoba González, Maria Helena de Agrela Gonçalves Jardim, Rita Silva, Cristina Lavareda Baixinho, Ma Helena Presado, Ma Fátima Marques, Mário E. Cardoso, Marina Cunha, Joana Mendes, Ana Xavier, Ana Galhardo, Margarida Couto, João Frade, Carla Nunes, João R. Mesquita, María Säo José Nascimento, Guilherme Gonçalves, Conceição Castro, Alice Mártires, M. João Monteiro, Conceição Rainho, Francisco P. Caballero, Fátima M. Monago, José T. Guerrero, Rocio M. Monago, Africa P. Trigo, Milagros L. Gutierrez, Gemma M. Milanés, Mercedes G. Reina, Ana G. Villanueva, Ana S. Piñero, Isabel R. Aliseda, Francisco Buitrago Ramírez, Andrea Ribeiro, Ana Quelhas, Maria Conceição Manso, Francisco P. Caballero, José T. Guerrero, Fátima M. Monago, Rafael Brito Santos, Nuria R. Jimenez, Cristina G. Nuñez, Inmaculada Rodríguez Gómez, Ma Jose L. Fernandez, Laura A. Marquez, Ana L. Moreno, Ma Jesus Tena Huertas, Francisco Buitrago Ramírez, Daniel Seabra, Ma Céu Salvador, Luciene Muniz Braga, Pedro Parreira, Anabela Salgueiro‐Oliveira, Cristina Arreguy-Sena, Bibiana F. Oliveira, Ma Adriana Henriques, Joana Santos, Sara Lebre, Alda Marques, Clarinda Festas, Sandra Rodrigues, Andrea Ribeiro, José Lumini‐Oliveira, Ana Gabriela Figueiredo, Francisco J. Hernandez-Martinez, Liliana Campi, Ma Pino Quintana-Montesdeoca, Juan F. Jimenez-Diaz, Bienvenida C. Rodriguez-De-Vera, Alexandra Parente, Ma Augusta Mata, Ana Ma Pereira, Adília Fernandes, Manuel Brás, Ma Rosário Pinto, Pedro Parreira, Marta Lima Basto, Ana C. Rei, Lisete Mónico, Gilberta Sousa, Clementina Morna, Otília Freitas, Gregório Freitas, Ana Carolina Gomes Jardim, Rita P. Vasconcelos, Lina G. Horta, Roger dos Santos Rosa, Luís Fernando Kranz, Rita C. Nugem, Mariana Santiago Siqueira, Ronaldo Bordin, Rosiane Kniess, Josimari Telino de Lacerda, Joana Guedes, Idalina Machado, Sidalina Almeida, Adriano Zilhão, Hélder Alves, Óscar Ribeiro, Ana Paula Martins Amaral, Ana Maria Ribeiro dos Santos, Joana Monteiro, Ma Clara Rocha, Rui Cruz, Ana Paula Martins Amaral, Marina Lourenço, Ma Clara Rocha, Rui Cruz, Sandra Regina Masetto Antunes, Verónica Mendonça, Isabel Andrade, Nádia Osório, Ana Valado, Armando Caseiro, Antonio Padua y Gabriel, Anabela Correia Martins, Fernando Mendes, Lídia Cabral, Manuela Ferreira, Amadeu Gonçalves, Tatiana Durão D`Ávila Luz, Leonardo Gomes de Oliveira Luz, Raúl A. Martins, Alice Murteira Morgado, Maria da Luz Vale-Dias, Rui Porta-Nova, Tânia Cristina Malezan Fleig, Éboni Marília Reuter, Miriam Beatris Froemming, Sabrina Luciane Camara Guerreiro, Lisiane Lisbôa Carvalho, Daniel Guedelha, Pedro S. Coelho, A.T. Pereira, António Calha, Raúl Cordeiro, Ana Gonçalves, Ana Certo, Ana Cristina Araújo de Andrade Galvão, Ma Augusta Mata, Aline Welter, Elayne Crestani Pereira, Sandra Aparecida Ribeiro, Márcia Regina Kretzer, Juan-Fernando Jiménez-Díaz, Carla Jiménez-Rodríguez, Francisco-José Hernández-Martínez, Bienvenida-Del-Carmen Rodríguez-De-Vera, Alexandre Marques-Rodrigues, Patrícia Brazil Pereira Coelho, Tiago Bernardes, Alexandre de Araújo Pereira, Patrícia Sousa, João Ghizzo Filho, Nazaré Otília Nazário, Márcia Regina Kretzer, Odete Amaral, António Garrido, Nélio Veiga, Carla Nunes, Ana Rita Pedro, Carlos Pereira, António Almeia, Hélder Miguel Fernandes, Carlos Vasconcelos, Nélson Sousa, Víctor Machado Reis, M. João Monteiro, Romeu Mendes, Isabel Pinto, Tânia C. S. P. Pires, João Gama, Vera Preto, Norberto Silva, Carlos Pires Magalhães, Matilde Martins, Mafalda Duarte, Constança Paúl, Ignácio Martín, Arminda Pinheiro, S. Xavier, J. Azevedo, E. Bento, C. Marques, M. Marques, A. Macedo, A.T. Pereira, José Pedro Almeida, António Almeida, Josiane Alves, Nélson Sousa, Francisco Saavedra, Romeu Mendes, Ana S. Maia, Michelle Teixeira Oliveira, Anderson Reis de Sousa, Paulo P. Ferreira, Luci S. Lopes, Eujcely C. Santiago, Sílvia Monteiro, Ângelo Jesus, Armanda Colaço, Antônio Ivo de Carvalho, Rita P. Silva, Agostinho Cruz, Ana Ferreira, Catarina Marques, João Paulo Figueiredo, Susana Paix�ão, Ana Ferreira, Carla Lopes, Fernando Moreira, João Paulo Figueiredo, Ana Ferreira, Diana Ribeiro, Fernando Moreira, João Paulo Figueiredo, Susana Paix�ão, Telma Fernandes, Diogo Amado, Jéssica Denise Vieira Leal, Marcelo Costa Velho Mendes de Azevedo, Sónia Ramalho, Catarina Mangas, Jaime Ribeiro, Rita Maria de Abreu Gonçalves, Amélia Fernandes Nunes, Ana Rita Tuna, Carlos Martins, Henriqueta D. Forte, Cláudia Costa, José António Tenedório, Paula Santana, José Augusto Andrade, Joana Pinto, C. Campofiorito, S. C. Nunes, Ana Sofia Carmo, A. Kaliniczenco, Bárbara Shibuya Alves, Francisco Mendes, Carlos Jesus, Felipe Paiva Fonseca, Flávia de Sousa Gehrke, Carlos Albuquerque, Rita Batista, Madalena Cunha, António Dias, Olivério Ribeiro, Rosa Maria Grangeiro Martins, Teresa Madeira, Catarina Peixoto-Plácido, Nuno Rebelo dos Santos, Osvaldo Santos, Astrid Bergland, Asta Bye, Carla Lopes, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Nicola, J. Gorjão Clara, João Gomes, Ana Querido, Catarina Tomás, Daniel Carvalho, Marina Cordeiro, Marlene Rosa, Alda Marques, Daniela Brandão, Óscar Ribeiro, Lia Araújo, Constança Paúl, Beatriz Minghelli, Sylvina Richaud, Ana Laura Mendes, Joana Marta‐Simões, Inês A. Trindade, Cláudia Ferreira, Teresa Carvalho,
... after the disaster event on February 20, 2010 Helena G. Jardim, Rita Silva O2 Musculoskeletal disorders in midwives Cristina L. Baixinho, Mª Helena Presado, Mª Fátima Marques, Mário E. Cardoso O3 ...
BioMed Central
Produção Nacional
Revisado por pares
Camila Lopes Cardoso, Cláudia Curra, Marcos Martins Curi, Mariza Akemi Matsumoto, Camila Dionísio ARGENTINO, Solange de Oliveira Braga Franzolin, Dulce Helena Jardim Constantino, Daniela Nicolielo BARBOSA, Osny Ferreira Júnior,
The present study aimed to investigate the use of platelet-rich plasma (PRP) on tooth extraction sites in rats treated with bisphosphonates. Thirty Albinus Wistar male rats were administered 0.035 mg/kg zoledronic acid intravenously for 8 weeks, divided into four administrations with a 2-week interval between each application, after which their upper right central incisors were extracted to induce the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The samples were divided ...
Tópico(s): Oral and gingival health research
2019 - Brazilian Society of Dental Research | Brazilian Oral Research
Produção Nacional
Revisado por pares
Ana Priscila Gomes Silva, Marcella da Silva Araújo Santiago, Luciane Alves Maranho, Rodolpho Pereira de Oliveira, Dulce Helena Jardim Constantino, Camilo Dias Seabra Pereira, Regina Cláudia Barbosa da Silva, Juliana Elaine Perobelli,
Manganese (Mn) is one of the most common chemical elements on Earth and an essential micronutrient in animal organism. However, in supraphysiological levels and long-term exposures, it is a potential toxicant. Although nervous system is the most studied in relation to Mn toxicity, other tissues can have their function impaired by Mn in high doses. The present study investigated the possible adverse effects of subchronic exposure to supraphysiologic level of Mn (5 mg/kg or 15 mg/kg, intraperitoneally) ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2018 - Elsevier BV | Toxicology
Produção Nacional
Revisado por pares
Adriana Giongo, Adriana Ambrosini, Luciano Kayser Vargas, J. R. Jardim Freire, Maria Helena Bodanese‐Zanettini, Luciane Maria Pereira Passaglia,
The massive inoculation of Brazilian soils with few bradyrhizobia strains recommended for soybean has resulted in an established population in most soils cropped with this legume. Besides, several environmental conditions are limiting factors to the growth and activity of rhizobia in soil. These features can shape soil and plant-associated habitats, modifying the composition and activities of their microbial communities. In this work, five bacterial populations from distinct regions of Rio Grande ...
Tópico(s): Soybean genetics and cultivation
2007 - Elsevier BV | Applied Soil Ecology
Produção Nacional
Revisado por pares
Zorano Sérgio de Souza, Hervé Martin, Jean-Jacques Peucat, Emanuel Ferraz Jardim de Sá, Maria Helena De Freitas Macedo,
The Paleoproterozoic metaplutonic rocks of the Caico* Complex Basement (Serido* region, NE Brazil) provide important and crucial insights into the petrogenetic processes governing crustal growth and may potentially be a proxy for understanding the Archean^ Proterozoic transition. These rocks consist of high-K calc-alkaline diorite to granite, with Rb^Sr, U^Pb, Pb^Pb and Sm^Nd ages of c. 225^215 Ga. They are metaluminous, with high YbN, K2O/Na2Oand Rb/Sr, low ISr ratios, and are large ion lithophile ...
Tópico(s): High-pressure geophysics and materials
2007 - Oxford University Press | Journal of Petrology
Marisol Gouveia, João Figueira, Manuel G. Jardim, Rita Castro, Helena Tomás, Kari Rissanen, João Rodrigues,
Here and for the first time, we show that the organometallic compound [Ru(η⁵-C₅H₅)(PPh₃)₂Cl] (RuCp) has potential to be used as a metallodrug in anticancer therapy, and further present a new approach for the cellular delivery of the [Ru(η⁵-C₅H₅)(PPh₃)₂]⁺ fragment via coordination on the periphery of low-generation poly(alkylidenimine) dendrimers through nitrile terminal groups. Importantly, both the RuCp and the dendrimers functionalized with [Ru(η⁵-C₅H₅)(PPh₃)₂]⁺ fragments present remarkable toxicity ...
Tópico(s): Ferrocene Chemistry and Applications
2018 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Céline Jézéquel, Pablo A. Tedesco, Rémy Bigorne, Javier A. Maldonado‐Ocampo, Hernán Ortega, Max Hidalgo, Koen Martens, Gislene Torrente‐Vilara, Jansen Zuanon, Astrid Acosta, Edwin Agudelo Córdoba, Soraya Barrera Maure, Douglas Aviz Bastos, Juan David Bogotá-Gregory, Fernando G. Cabeceira, André Luiz Colares Canto, Fernando M. Carvajal‐Vallejos, Lucélia Nobre Carvalho, Ariana Cella‐Ribeiro, Raphaël Covain, Carlos DoNascimiento, Carolina Rodrigues da Costa Dória, Cleber Duarte, Efrem Ferreira, André V. Galuch, Tommaso Giarrizzo, Rafael P. Leitão, John G. Lundberg, Mabel Maldonado, José Iván Mojica, Luciano Fogaça de Assis Montag, Willian Massaharu Ohara, Tiago Henrique da Silva Pires, Marc Pouilly, Saúl Prada‐Pedreros, Luiz Jardim de Queiroz, Lúcia Helena Rapp Py‐Daniel, Frank Raynner Vasconcelos Ribeiro, Raúl Ríos Herrera, Jaime Sarmiento, Leandro Melo de Sousa, Lis F. Stegmann, Jonathan Valdiviezo‐Rivera, Francisco Villa, Takayuki Yunoki, Thierry Oberdorff,
Abstract The Amazon Basin is an unquestionable biodiversity hotspot, containing the highest freshwater biodiversity on earth and facing off a recent increase in anthropogenic threats. The current knowledge on the spatial distribution of the freshwater fish species is greatly deficient in this basin, preventing a comprehensive understanding of this hyper-diverse ecosystem as a whole. Filling this gap was the priority of a transnational collaborative project, i.e . the AmazonFish project - https://www. ...
Tópico(s): Fish Ecology and Management Studies
2020 - Nature Portfolio | Scientific Data
Produção Nacional
Revisado por pares
Ivanete da Silva Santiago Strefling, Cristiane Brignol Borba, Marilu Correa Soares Correa Soares, Carolina Carbonell Demori, Cármen Helena Gomes Jardim Vaz, Cristiano Pinto dos Santos,
RESUMO Objetivo: Conhecer a percepção das puérperas sobre o atendimento dos profissionais de enfermagem no alojamento conjunto. Métodos: Estudo qualitativo exploratório-descritivo, realizado em um hospital de médio porte no interior do Rio Grande do Sul com 15 mulheres no puerpério imediato. O projeto foi aprovado pelo Comitê de Ética em Pesquisa da Universidade da Região da Campanha, sob o número do CAAE 62/2013. Utilizou-se a letra “P” para identificar as puérperas, seguidos pelo número sequencial ...
Tópico(s): Health, Nursing, Elderly Care
2017 - UNIVERSIDADE FEDERAL DO ESTADO DO RIO DE JANEIRO | Revista de Pesquisa Cuidado é Fundamental Online
Maria Faria, Conceição Mota, José Barbot, Sílvia Álvares, Helena Jardim, António Vilarinho, Elói Pereira,
Tópico(s): Food Allergy and Anaphylaxis Research
2000 - Oxford University Press | Nephrology Dialysis Transplantation
Produção Nacional
Revisado por pares
Mariana Simões Garcia, Dulce Helena Jardim Constantino, Ana P. G. Silva, Juliana Elaine Perobelli,
This study investigated whether or not prepubertal exposure to the fish contaminants methylmercury (MeHg) and the polychlorinated bisphenol Aroclor in low doses interferes with the histomorphometry of the testes, epididymis, liver and kidneys in rats. Wistar male rats, 21 days old, were allocated into the following: control (n = 17, received corn oil), MeHg (n = 17, received MeHg at 0.5 mg/kg/day), Aroclor (n = 17, received Aroclor at 1.0 mg/kg/day), low mix (n = 18, received MeHg at 0.05 mg/kg/day and Aroclor ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2016 - Wiley | International Journal of Experimental Pathology
Maria Cristina de Oliveira Izar, Tatiana Helfenstein, Sílvia Saiuli Miki Ihara, Waldir Gabriel Miranda Relvas, Andreza O. Santos, Simone Cristina Matheus Fischer, L.E.S. Almeida Pinto, Ieda Edite Lanzarini Lopes, Daniel R Pomaro, Marília Izar Helfenstein Fonseca, Luís Carlos Bodanese, Emílio Hideyuki Moriguchi, José Francisco Kerr Saraiva, Luiz Introcaso, Agnaldo D. de Souza, Mariléia Scartezini, Kerginaldo Paulo Torres, Leãõ Zagury, Paulo César Brandão Veiga Jardim, Eduardo A. Costa, Lúcia Helena Bonalume Tácito, Adriana Costa e Forti, Maria Eliane Campos Magalhães, Antônio Roberto Chacra, Marcelo Chiara Bertolami, Andréia Assis Loures-Vale, Marco A. Barros, Hermes Tóros Xavier, Ruy Lyra, Dikran Argamanijan, Armênio Costa Guimarães, José Paulo Novazzi, N Kasinski, Abrahão Afiune, Tânia Leme da Rocha Martinez, Raúl D. Santos, José Carlos Nicolau, Luı́z Antonio Machado César, Rui Póvoa, Antônio Carlos Carvalho, Sang Won Han, Francisco Antônio Helfenstein Fonseca,
The association of polymorphisms affecting lipid metabolism with the risk of myocardial infarction (MI) in type 2 diabetes mellitus was investigated. The Genetics, Outcomes and Lipids in type 2 Diabetes (GOLD) Study is a prospective, multicenter study, conducted on 990 patients presenting diabetes and MI (n = 386), or diabetes without previous manifestation of stroke, peripheral or coronary arterial disease (n = 604), recruited from 27 institutions in Brazil. APO A1 (A/G −75 and C/T +83) and APO C3 (C/G 3'UTR) ...
Tópico(s): Lipoproteins and Cardiovascular Health
2008 - Elsevier BV | Atherosclerosis
João Rodrigues, Manuel G. Jardim, João Figueira, Marisol Gouveia, Helena Tomás, Kari Rissanen,
The aim of this article is to highlight the use of nitrile-functionalized poly(alkylidenamines) dendrimers as building blocks for the preparation of low-generation ruthenium based cationic metallodendrimers having in view potential biomedical applications. Air-stable poly(alkylidenamines) nitrile dendrimers, peripherally functionalized with the ruthenium moieties [Ru(η5-C5H5)(PPh3)2]+ or [RuCl(dppe)2]+, have been prepared, characterized and are being studied for their anticancer activity. The followed ...
Tópico(s): Chemical Synthesis and Analysis
2011 - Royal Society of Chemistry | New Journal of Chemistry
Produção Nacional
E. F. Jardim de, Reinhardt A. Fuck, Maria Helena De Freitas Macedo, Jean Jacques Peucat, Koji Kawashita, Zorano Sérgio de Souza, Jean Bertrand,
The Serido Belt (Borborema Province, NE Brazil) comprises Proterozoic supracrustal formations (the Serido Group), its gneissic basement and granitoid plutons. The older intrusions (the G 2 orthogneisses) were affected by penetrative tangential deformation (D 2 event). The Brasiliano transcurrent deformation (D 3 ) overprints structures ascribed to the older (D 2 ) tangential regime, whose absolute age is still under debate. A 1.99+0.01 Ga Pb/Pb zircon evaporation date was obtained from a G 2 augen gneiss ...
Tópico(s): earthquake and tectonic studies
1995 - Sociedade Brasileira de Geologia | Brazilian Journal of Geology
Produção Nacional
EMANUEL FERRAZ JARDIM DE, Reinhardt A. Fuck, Maria Helena De Freitas Macedo, JEAN JACQUES PEUCAT, KOJI KAWASHITA, Zorano Sérgio de Souza, JEAN MICHEL BERTRAND,
A Faixa Seridó (Provincia Borborema, NE do Brasil) comprende formafoes supracrustais proterozoicas (o Grupo Seridó), seu embasamento gndissico e plutons granitdides.As intrusoes mais antigas
Tópico(s): Geological formations and processes
1995 - Sociedade Brasileira de Geologia | Revista Brasileira de Geociências
Produção Nacional
Revisado por pares
Olívia Teixeira Gomes Reis, Juliana Crepaldi Raini, Silvana Torossian Coradi, Dulce Helena Jardim Constantino,
Evaluate polymorphonuclear leukocytes (PMN's) and mononuclear cells (MN's) involvement in the Ehrlich s solid tumor (ET) growth.90 Swiss mice were inoculated with 10(7) tumor cells (sc), distributed in three groups and treated once a day, via intraperitoneal (ip), with 0.1ml of diluent, L-Arginine (20mg/Kg) or L-NAME (20mg/Kg). After 7, 15 and 30 days of treatment, ten animals of each group were euthanized, the tumor mass was removed, processed and fixed for HE. Later, a morphometric analysis of the total ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2009 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Produção Nacional
Revisado por pares
Helena Moraes Jardim de Azevedo, Nataly Winni Fernandes dos Santos, Mariana Lima Lafetá, André Luís Pereira de Albuquerque, Suzana Érico Tanni, Priscila A. Sperandio, Eloara V.M. Ferreira,
Many patients hospitalized with COVID-19 were unable to return to work or their return was delayed due to their health condition. The aim of this observational study was to evaluate the impact of moderate-to-severe and critical COVID-19 infection on persistence of symptoms and return to work after hospital discharge. In this study, two thirds of hospitalized patients with pulmonary involvement reported persistence of symptoms six months after COVID-19 infection, such as memory loss (45.5%), myalgia ( ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2022 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Walter Sermeus, Nicky Cullum, Katrin Balzer, Rhian Schröder, Anne Junghans, Ute Stahl, Jens-Martin Träder, Sascha Köpke, Martin Dichter, Rebecca Palm, Margareta Halek, Sabine Bartholomeyczik, Gabriele Meyer, Daniela Holle, Rabea Graf, Ute Rosier, Sven Reuther, Martina Roes, Margareta Halek, Bruna R. Gouveia, Maria Helena de Agrela Gonçalves Jardim, María Manuela Martins, Duarte Freitas, José Maia, Debra J. Rose, Élvio Rúbio Gouveia, Luk Bruyneel, Emmanuel Lesaffre, Walter Sermeus, Jane Ball, Luk Bruyneel, Linda H. Aiken, Carol Tishelman, Walter Sermeus, Peter Griffiths, Evridiki Papastavrou, Panayiota Andreou, Loredana Sasso, Annamaria Bagnasco, Milko Zanini, Gianluca Catania, Giuseppe Aleo, Federico Spandonaro, Giancarlo Icardi, Roger Watson, Walter Sermeus, Steffen Fleischer, Marion Burckhardt, Gabriele Meyer, Almuth Berg, Ann Van Hecke, Simon Malfait, Johan Van Daele, Kristof Eeckloo, Mieke Deschodt, Bastiaan Van Grootven, Koen Milisen, Johan Flamaing, Anne Christin Rahn, Sascha Köpke, Imke Backhus, Jürgen Kasper, Anna Krützelmann, Ingo Kleiter, Ingrid Mühlhauser, Christoph Heesen,
Tópico(s): Healthcare Systems and Public Health
2016 - BioMed Central | BMC Nursing
Produção Nacional
Revisado por pares
E. F. Jardim de, Ricardo I.F. Trindade, Maria Helena Bezerra Maia de Hollanda, João Maria Martins de Araújo, Antônio Carlos Galindo, Venerando Eustáquio Amaro, Zorano Sérgio de Souza, Jean‐Louis Vigneresse, J.-M. Lardeaux,
Tópico(s): earthquake and tectonic studies
1999 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
Luísa Jardim Corrêa de Oliveira, Mariana Gonzalez Cademartori, Helena Silveira Schuch, Fernando C. Barros, Mariângela Freitas da Silveira, Marcos Britto Corrêa, Flávio Fernando Demarco,
Abstract Objectives To verify the association between periodontal conditions and preterm birth. Materials and methods This study used data from the 2015 Pelotas Birth Cohort Study, Brazil. Pregnant women expected to give birth in 2015 were interviewed and dentally examined by a trained dentist, with periodontal measures collected in all teeth, six sites per tooth. Exposure was periodontal disease. Outcomes were preterm birth (all births <37 weeks of gestational age) and early preterm birth (<34 weeks). ...
Tópico(s): Preterm Birth and Chorioamnionitis
2020 - Wiley | Oral Diseases
Produção Nacional
Revisado por pares
Raimunda Magalhães da Silva, Christina César Praça Brasil, Indara Cavalcante Bezerra, Maria do Livramento Fortes Figueiredo, Míria Conceição Lavinas Santos, Jonas Loiola Gonçalves, Maria Helena de Agrela Gonçalves Jardim,
Resumo Investiga desafios e possibilidades de profissionais de saúde para a gestão do cuidado de idosos dependentes na Atenção Primária à Saúde. Recorreu-se à abordagem qualitativa fundamentada na fusão hermenêutica dialética. Efetivou-se entrevista com 38 profissionais de saúde, nos meses de junho a dezembro de 2019, em oito cidades das cinco regiões brasileiras. Dos resultados, emergiram temáticas sobre os desafios que os profissionais enfrentam na gestão do cuidado ao idoso, as estratégias por ...
Tópico(s): Elder Abuse and Neglect
2021 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva