María Marcuello, Xavier Mayol, Eloísa Felipe-Fumero, Jaume Costa, Laia López-Hierro, Sílvia Salvans, Sandra Alonso, Marta Pascual, Luís Grande, Miguél Pera,
Peritoneal infection after colorectal cancer surgery is associated with a higher rate of tumor relapse. We have recently proposed that soluble inflammatory factors released in response to a postoperative infection enhance tumor progression features in residual tumor cells. In an effort to set up models to study the mechanisms of residual tumor cell activation during surgery-associated inflammation, we have analyzed the phenotypic response of colon cancer cell lines to the paracrine effects of THP- ...
Tópico(s): Endometriosis Research and Treatment
2018 - Public Library of Science | PLoS ONE
M. Caplin, Éric Baudin, Piero Ferollà, Pier Luigi Filosso, Mariano García‐Yuste, Eric Lim, Kjell Öberg, Giuseppe Pelosi, Aurel Perren, Roberta Rossi, William D. Travis, D.K. Bartsch, Jaume Capdevila, Frederico Costa, Jarosław B. Ćwikła, Wouter W. de Herder, Gianfranco Delle Fave, Barbro Eriksson, Massimo Falconi, Diego Ferone, David J. Gross, Ashley Grossman, Tetsuhide Ito, Robert T. Jensen, Gregory Kaltsas, Fahrettin Keleştimur, Réza Kianmanesh, Ulrich Knigge, Beata Kos‐Kudła, Eric P. Krenning, Emmanuel Mitry, M. Nicolson, Juan Manuel O’Connor, Dermot O’Toole, Ulrich-Frank Pape, Marianne Pavel, John Ramage, Éric Raymond, Guido Rindi, Andrea Rockall, Philippe Ruszniewski, Ramón Salazar, Aldo Scarpa, Eva Sedláčková, Anders Sundin, Christos Toumpanakis, Marie‐Pierre Vullierme, Wolfgang Weber, Bertram Wiedenmann, Zeng Zheng-Pei,
BackgroundPulmonary carcinoids (PCs) are rare tumors. As there is a paucity of randomized studies, this expert consensus document represents an initiative by the European Neuroendocrine Tumor Society to provide guidance on their management.Patients and methodsBibliographical searches were carried out in PubMed for the terms ‘pulmonary neuroendocrine tumors’, ‘bronchial neuroendocrine tumors’, ‘bronchial carcinoid tumors’, ‘pulmonary carcinoid’, ‘pulmonary typical/atypical carcinoid’, and ‘pulmonary carcinoid ...
Tópico(s): Lung Cancer Research Studies
2015 - Elsevier BV | Annals of Oncology
Thibault Péan, Jaume Salom, Ramon Costa‐Castelló,
The present work constitutes a review of the existing literature on supervisory control for improving the energy flexibility provided by heat pumps in buildings. A distinction was drawn between rule-based controls (RBC) and model predictive controls (MPC), given the clear differences in their concept and complexity. For both kinds, the different objectives claimed by these strategies have been reviewed, as well as the control inputs, disturbances and constraints. Notably in MPC, the monetary objective ( ...
Tópico(s): Smart Grid Energy Management
2018 - Elsevier BV | Journal of Process Control
Marta Hernández, C. Mestres, Pilar Modamio, Jaume Junyent, Lluís Costa, Cecilia Fernández Lastra, Eduardo L. Mariño,
Older people usually present with adverse drug events (ADEs) with nonspecific symptoms such as cognitive decline, recurrent falls, reduced mobility, and/or major deterioration. The aims of this study were to assess the ADEs of patients with dementia and presenting neuropsychiatric/behavioral, and psychological symptoms in dementia (BPSD) and to categorize and identify the principal factors that allow to prevent ADEs, and separately ADEs that result in falls. To that end, a one-year prospective study ...
Tópico(s): Patient Safety and Medication Errors
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Isidró Ferrer, Fábio Wildson Gurgel Costa, Jaume Veciana,
A cerebral biopsy of a patient with Creutzfeldt‐Jacob (C‐J) disease was examined with the Golgi method. Distortion of soma and neuronal processes associated with vacuolization of the neuropil was observed. The main findings were decreased numbers of basal dendrites and of branches of the apical dendrite of the pyramidal cells, marked loss of synaptic spines, and varicosities in the proximal segment of some apical and basal dendrites. These changes, though non‐specific, may be interpreted as the result ...
Tópico(s): Biomedical Research and Pathophysiology
1981 - Wiley | Neuropathology and Applied Neurobiology
Odón Arjona, Rocío Alonso Medel, Jenny K. Rojas, Anna M. Costa, Jaume Vilarrasa,
The conjugate addition of aliphatic and aromatic thiols to ethynyl p-tolyl sulphone (tosylacetylene) has been managed to afford Tosvinyl derivatives chemoselectively (in the presence of oxygen nucleophiles) and stereoselectively (isomers Z) in practically quantitative yields. The conditions of choice are: catalytic amounts of Et3N (only 0.5–1.0 mol%), a reaction temperature around 0°C and, for the less acidic thiols, CF3CH2OH or CH3CN/CF3CH2OH as the solvent. Thus, N-Boc-Cys-OMe has been quantitatively ...
Tópico(s): Chemical Synthesis and Analysis
2003 - Elsevier BV | Tetrahedron Letters
Jorge Martín Esteban, Anna M. Costa, Jaume Vilarrasa,
The key C10-C26 fragment in a total synthesis of (-)-amphidinolide E has been prepared from an oxolane-containing C10-C17 segment (9, derived from L-glutamic acid) via a Julia-Kocienski reaction with aldehyde 3, followed by a Sharpless AD to obtain the desired diol. The C22-C26 fragment was installed by means of an efficient Suzuki-Molander coupling, with an organotrifluoroborate reagent (4, arising from a cross-metathesis reaction between a vinylboronate and 2-methyl-1,4-pentadiene).
Tópico(s): Marine Sponges and Natural Products
2008 - American Chemical Society | Organic Letters
Mireia Sidera, Anna M. Costa, Jaume Vilarrasa,
The C–Si bonds of triisopropylsilyl-substituted alkenes, 1,3-dienes, and related multifunctional substrates, as well as analogous C–TBDPS and C–TBS bonds, are readily and chemoselectively cleaved with NIS (or other sources of I+, such as N-iodosaccharin, 1,3-diodohydantoin, and Ipy2BF4). The desired iodoalkenes are obtained stereospecifically without byproducts, provided that the reactions are carried out in CF3CHOHCF3 and, in general, with 30 mol % of Ag2CO3 (or AgOAc/2,6-lutidine) as an additive. ...
Tópico(s): Marine Toxins and Detection Methods
2011 - American Chemical Society | Organic Letters
Marianne Pavel, Dermot O’Toole, Frederico Costa, Jaume Capdevila, Danae C. Gross, Réza Kianmanesh, E. P. Krenning, Ulrich Knigge, Ramón Salazar, Ulrich‐Frank Pape, Kjell Öberg,
The goal of this paper is to update a more extensive review and guidelines paper published in 2012 [1] . Gen-erally, any pertinent update pertaining to the diagnosis and staging of individual prima ...
Tópico(s): Lung Cancer Research Studies
2016 - Karger Publishers | Neuroendocrinology
B Costa, Jaume Arroyo, A Sabaté,
Tópico(s): Pharmaceutical Practices and Patient Outcomes
1997 - Adis, Springer Healthcare | PharmacoEconomics
Lluís Bosch, Laura Mola, Elena Petit, Mar Saladrigas, Jorge Martín Esteban, Anna M. Costa, Jaume Vilarrasa,
A formal total synthesis of the cytotoxic macrolide amphidinolide E is reported. The strategic steps are three Julia–Kocienski reactions (J–K), for the formation of the C5–C6, C9–C10, and C17–C18 double bonds, a Suzuki–Molander C21–C22 bond formation reaction, and a Kita–Trost macrolactonization. The "instability" of the two dienic systems and of the stereocenter at C2 (allylic methine, α to the carboxy group) and the protecting groups at C17-OH and C18-OH have posed difficult challenges. Each Julia– ...
Tópico(s): Marine Toxins and Detection Methods
2017 - American Chemical Society | The Journal of Organic Chemistry
Alejandro Castro‐Álvarez, Anna M. Costa, Jaume Vilarrasa,
The accuracy of five docking programs at reproducing crystallographic structures of complexes of 8 macrolides and 12 related macrocyclic structures, all with their corresponding receptors, was evaluated. Self-docking calculations indicated excellent performance in all cases (mean RMSD values ≤ 1.0) and confirmed the speed of AutoDock Vina. Afterwards, the lowest-energy conformer of each molecule and all the conformers lying 0-10 kcal/mol above it (as given by Macrocycle, from MacroModel 10.0) were subjected ...
Tópico(s): Protein Structure and Dynamics
2017 - Multidisciplinary Digital Publishing Institute | Molecules
M. Arigita, M. Illa, Alfons Nadal, Célia Bádenas, Anna Soler, N. Alsina, A. Borrell,
... Arana 1, 08028 Barcelona, Catalonia, Spain, § Hospital Sant Jaume de Calella, Calella de la Costa, Catalonia, Spain, ¶ CIBERER, IDIBAPS
Tópico(s): Prenatal Screening and Diagnostics
2010 - Wiley | Ultrasound in Obstetrics and Gynecology
Produção Nacional
Carolina de Medeiros Rimkus, Vinícius Andreoli Schoeps, Mateus Boaventura de Oliveira, Luís Filipe de Souza Godoy, Samira Luísa Apóstolos‐Pereira, Ana Luísa Calich, Dagoberto Callegaro, Leandro Tavares Lucato, Àlex Rovira, Jaume Sastre‐Garriga, Cláudia da Costa Leite,
Some drugs and medications can precipitate immune system deregulations, which might be confused with recurrent demyelinating diseases, such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMO), exacerbations of an existing disease, neoplastic lesions or other conditions. In this narrative review we describe some of the most relevant drugs and medications associated with iatrogenic demyelination. The anthelminthic agent levamisole is a frequent cocaine adulterant and can precipitate ...
Tópico(s): Multiple Sclerosis Research Studies
2021 - Elsevier BV | Multiple Sclerosis and Related Disorders
Produção Nacional
Jacklyn D. Reis, Agostinho Castro, João C. W. A. Costa, Jaume Rius i Riu, Klas Ericson,
This paper describes Sequence Time Domain Reflectometry (STDR) and Spread Spectrum Time Domain Reflectometry (SSTDR), which utilizes concepts from direct sequence spread spectrum communications, as a technique for detecting impedance mismatches in telephone lines (twisted pair). The aim of this paper is to present methodologies for characterizing a subscriber loop, which is used for Digital Subscriber Line (DSL) technology, based on STDR and SSTDR tests. Those tests enable the TDR functionality to be ...
Tópico(s): Full-Duplex Wireless Communications
2007 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Elena Petit, Lluís Bosch, Joan Font, Laura Mola, Anna M. Costa, Jaume Vilarrasa,
The use of the 2-(4-methylphenylsulfonyl)ethenyl (tosvinyl, Tsv) group for the protection of the NH group of a series of imides, azinones (including AZT), inosines, and cyclic sulfonamides has been examined. The Tsv-protected derivatives are obtained in excellent yields by conjugate addition to tosylacetylene (ethynyl p-tolyl sulfone). The stereochemistry of the double bond can be controlled at will: with only 1 mol % of Et3N or with catalytic amounts of NaH, the Z stereoisomers are generated almost ...
Tópico(s): Chemical Synthesis and Reactions
2014 - American Chemical Society | The Journal of Organic Chemistry
Jaume Balsells, Anna M. Costa, Patrick J. Walsh,
Abstract Several efficient and highly enantioselective titanium‐based catalysts promote the asymmetric addition of alkyl groups to aldehydes. The catalysts involved in these reactions have been found not to exhibit nonlinear behavior. We have been able to identify a series of chiral bis(sulfonamide)‐based titanium catalysts that do show nonlinear behavior. Monitoring of the product ee's (ee p 's) at different conversions and different temperatures has led us to propose that nonlinear behavior is caused ...
Tópico(s): Molecular spectroscopy and chirality
2001 - Wiley | Israel Journal of Chemistry
Elena Petit, Lluís Bosch, Anna M. Costa, Jaume Vilarrasa,
We have developed a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thiol groups (of Cys) to drugs and labels. An amino group is converted into its propynamide and, in aqueous media at 37 °C and pH 7.4, Cys derivatives are added. The oxopropene-1,3-diyl linker is formed with excellent Z selectivity without secondary reactions. No exchange with other thiols is observed.
Tópico(s): Sulfur-Based Synthesis Techniques
2019 - American Chemical Society | The Journal of Organic Chemistry
Joan Costa‐Font, Jaume García Villar,
ABSTRACT ** : Captivity to a mainstream public insurer, is hypothesized to constrain the choice of purchasing private health insurance, by influencing risk attitudes. Namely, risk averse individuals are more likely to stay captive to the National Health System (NHS). To empirically test this hypothesis we use a small scale database from Catalonia to explore the determinants of private health insurance (PHI) purchase under different forms of captivity along with a measure of risk attitudes. Our results ...
Tópico(s): Healthcare Systems and Reforms
2009 - Wiley | Annals of public and co-operative economy
Joan Costa‐Font, Jaume García Villar,
Perceived quality of private and public health care, income and insurance premium are among the determinants of demand for private health insurance (PHI). In the context of a model in which individuals are expected utility maximizers, the non purchasing choice can result in consuming either public health care or private health care with full cost paid out-of-pocket. This paper empirically analyses the effect of the determinants of the demand for PHI on the probability of purchasing PHI by estimating ...
Tópico(s): Gender, Labor, and Family Dynamics
2002 - Wiley | Health Economics
Fernando Valladares, David Tena, Silvia Matesanz, E. Bochet, Luís Balaguer, M. Costa‐Tenorio, Jaume Tormo, P. García‐Fayos,
Abstract Question: What is the main ecological process determining species assemblage in roadside herbaceous plant communities? Location: Roadside slopes (roadcuts and embankments) in the south (Málaga, mesic Mediterranean) and east (Valencia, dry and continental) of the Iberian Peninsula. Methods: We identified 417 plant species, from which we selected the 331 most abundant (within the 70th abundance percentile) at each site. We compiled information on 28 functional traits and on the biogeographic ...
Tópico(s): Species Distribution and Climate Change
2008 - Wiley | Journal of Vegetation Science
Joan Costa‐Font, Jaume Puig‐Junoy,
English Scant evidence has been reported on the influence of institutional change in drug market regulation. This article draws on the evidence of Spanish drug regulation (1980-2005) with the aim of examining whether institutional (lack of) change affected (i) regulatory innovation and (ii) the propensity of regulatory failure (rent seeking). We find that the prevailing institutional design of Spanish drug regulation has been prone to regulatory failure as incentives were geared towards rent-seeking ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2007 - Policy Press | Policy & Politics
R. Vilella, D. Ben�tez, JW Foppe van Mil, Miquel Lozano, R. Vilana, Jaume Pomés, Xavier Tomás, Josep Costa, A. Vilalta, Josep Malvehy, Susana Puig, Begoña Mellado, Rosa Mart, T Castel,
Tópico(s): Immune Cell Function and Interaction
2004 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Thibault Péan, Ramon Costa‐Castelló, Jaume Salom,
Model predictive controllers (MPC) have shown great potential for activating the energy flexibility of thermal loads, especially in buildings equipped with heat pump systems. In this work, an MPC controller is developed and tested within a co-simulation framework which couples an optimization software with a dynamic building simulation tool. The development phase is described in detail, in particular the methods to obtain simplified models to be used by the controller. The building envelope and the ...
Tópico(s): Integrated Energy Systems Optimization
2019 - Elsevier BV | Sustainable Cities and Society
Anna M. Costa, Jaume Vilarrasa,
A few examples of hybrids/conjugates/chimeras of erythromycin A derivatives and nucleobases (uracil and thymine) or thymidine-derived nucleosides are reported. Linkers and reaction conditions have been investigated to avoid the degradation of the macrolide moiety (glycoside hydrolysis, ring cleavage, dehydration, etc.).
Tópico(s): Biochemical and Molecular Research
2000 - Elsevier BV | Tetrahedron Letters
Jaume Costa, Salvador Moncada,
... Advisory Council on Occupational Health—Barcelona Get access JAUME COSTA, JAUME COSTA Barcelona Healthy City Project Coordinator Barcelona, Spain Search ...
Tópico(s): Global Public Health Policies and Epidemiology
1989 - Oxford University Press | Health Promotion International
Alejandro Castro‐Álvarez, Héctor Carneros, Jaume Calafat, Anna M. Costa, C. Marco, Jaume Vilarrasa,
The addition of aldehyde enamines to nitroalkenes affords cyclobutanes in all solvents, with all of the pyrrolidine and proline derivatives tested by us and with all of the substrates we have examined. Depending on the temperature, concentration of water, solvent polarity, and other factors, the opening and hydrolysis of such a four-membered ring may take place rapidly or last for several days, producing the final Michael-like adducts (4-nitrobutanals). Thirteen new cyclobutanes have now been characterized ...
Tópico(s): Synthesis and Catalytic Reactions
2019 - American Chemical Society | ACS Omega
Marta Hernández, C. Mestres, Jaume Junyent, Lluís Costa, Pilar Modamio, Cecilia Fernández Lastra, Eduardo L. Mariño,
Objectives The aetiology of behavioural and psychological symptoms (BPSD) could be related to inadequate treatment in patients with dementia. The aim of this study was to determine how a multifaceted intervention based on a medication review and multidisciplinary follow-up could improve treatment and minimise risk in these patients. Methods A prospective interventional study was undertaken between July 2015 and July 2016 of patients with dementia admitted to control BPSD. Patients with previous psychiatric ...
Tópico(s): Schizophrenia research and treatment
2018 - BMJ | European Journal of Hospital Pharmacy
Joan R. Villalbí, Jaume Costa, Neus Oller,
This paper examines community organizations involved in the fight against AIDS and against unjustified fear of AIDS in the City of Barcelona, Spain. The political and social context for community organizations is reviewed, and the different registered organizations that have been involved in community initiatives against AIDS are presented, together with their actual role. Public support for community organizations related to AIDS and their relationship with the public administrations are studied. ...
Tópico(s): Social Sciences and Policies
1989 - Oxford University Press | Health Promotion International
Fidel Costa, Ralf Dohmen, Sagnik Chakraborty,
... the Zoning Patterns of Crystals Fidel Costa; Fidel Costa Institut de Ciencies de la Terra Jaume Almera, CSIC c/ LLuis Sole i Sabaris s/ ... GSW Google Scholar Author and Article Information Fidel Costa Institut de Ciencies de la Terra Jaume Almera, CSIC c/ LLuis Sole i Sabaris s/ ...
Tópico(s): earthquake and tectonic studies
2008 - Mineralogical Society of America | Reviews in Mineralogy and Geochemistry