José M. Mato, Javier Cámara, Javier Fernández de Paz, Llorenç Caballería, S. Coll, Antonio Caballero, Luisa Garcı́a-Buey, Joaquín Beltrán, Vicente Benita, Joan Caballería, R. Solá, Ricardo Moreno-Otero, F. Barrao, Antonio Martín‐Duce, José A. Correa, Albert Parés, Elena Barrao, Inmaculada García-Magaz, Jose Luis Puerta, Jorge Moreno, Gabrielle Boissard, P. Ortiz, Joan Rodés,
The efficacy of S-adenosylmethionine (AdoMet) in the treatment of liver cell injury has been demonstrated in several experimental models. The aim of this study was to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis.A randomized, double-blind trial was performed in 123 patients treated with AdoMet (1200 mg/day, orally) or placebo for 2 years. All patients had alcoholic cirrhosis, and histologic confirmation of the diagnosis was available in 84% of the cases. Seventy-five ...
Tópico(s): Alcohol Consumption and Health Effects
1999 - Elsevier BV | Journal of Hepatology
Javier Cámara, Javier Troya, Loli Burgueño, Antonio Vallecillo,
Abstract Most experts agree that large language models (LLMs), such as those used by Copilot and ChatGPT, are expected to revolutionize the way in which software is developed. Many papers are currently devoted to analyzing the potential advantages and limitations of these generative AI models for writing code. However, the analysis of the current state of LLMs with respect to software modeling has received little attention. In this paper, we investigate the current capabilities of ChatGPT to perform ...
Tópico(s): Model-Driven Software Engineering Techniques
2023 - Springer Science+Business Media | Software & Systems Modeling
Javier Cámara, Javier Troya, Antonio Vallecillo, Nelly Bencomo, Radu Călinescu, Betty H. C. Cheng, David Garlan, Bradley Schmerl,
Tópico(s): Service-Oriented Architecture and Web Services
2022 - Springer Science+Business Media | Software & Systems Modeling
Javier Torregrosa, Gema Bello-Orgaz, Eugenio Martínez‐Cámara, Javier Del Ser, David Camacho,
Extremism has grown as a global problem for society in recent years, especially after the apparition of movements such as jihadism. This and other extremist groups have taken advantage of different approaches, such as the use of Social Media, to spread their ideology, promote their acts and recruit followers. The extremist discourse, therefore, is reflected on the language used by these groups. Natural language processing (NLP) provides a way of detecting this type of content, and several authors ...
Tópico(s): Spam and Phishing Detection
2022 - Springer Science+Business Media | Journal of Ambient Intelligence and Humanized Computing
Marta Igual, Patricia García‐Herrera, R.M. Cámara, Javier Martínez‐Monzó, Purificación García‐Segovia, Montaña Cámara,
Rosa canina pseudo-fruits contain interesting bioactive compounds. This work aims to evaluate the use of different biopolymers as encapsulating agents on the content of organic acids, minerals, fibers, phenols, carotenoids, and the antioxidant activity of the powdered product. Fruits were ground and freeze-dried with or without biopolymers (maltodextrin, resistant maltodextrin, cyclodextrin, and pea protein). Rosehip formulated purees with encapsulating agents are an interesting food ingredient rich ...
Tópico(s): Proteins in Food Systems
2022 - Multidisciplinary Digital Publishing Institute | Molecules
José Antonio Pérez‐Simón, Rodrigo Martino, Dolores Caballero, David Valcárcel, Noemí Rebollo, Rafael de la Cámara, Javier Pérez de Oteiza, Inmaculada Heras, María Victoria Martínez Calvo, Jordi Sierra, Jesús F. San Miguel,
In the current study, we have analyzed the efficacy of cyclosporine A (CSA) plus mycophenolate mofetil (MMF) as graft-versus-host disease (GVHD) prophylaxis in the fludarabine plus melphalan or busulfan reduced intensity regimen (RIC) setting in a series of 44 patients receiving allogeneic transplantation from an unrelated donor. Only 23% were in the first complete remission at the time of transplant. Cumulative incidence of grades II-IV and III-IV acute GVHD (aGVHD) was 53% and 23%, respectively. Fifty- ...
Tópico(s): Acute Lymphoblastic Leukemia research
2008 - Elsevier BV | Biology of Blood and Marrow Transplantation
Javier Cámara, Carlos Canal, Javier Cubo, Juan M. Murillo,
This paper briefly describes the design of a dynamic adaptation management framework which exploits the concepts provided by Aspect-Oriented Software Development (AOSD), in particular Aspect-Oriented Programming (AOP). The framework uses reflection and adaptation techniques in order to support COTS composition and evolution by tackling issues related to signature and protocol interoperability. This provides a basic infrastructure for a non-intrusive, semi-automatic approach for syntactical and behavioural ...
Tópico(s): Software System Performance and Reliability
2007 - Elsevier BV | Electronic Notes in Theoretical Computer Science
Antonio Brogi, Javier Cámara, Carlos Canal, Javier Cubo, Ernesto Pimentel,
When developing systems based on COTS, components need to be adapted in most of the occasions to work under certain conditions which were not initially predicted by their developers. Thus, it is very important to provide systems with the skill to dynamically alter their behaviour while running, depending on the changing conditions of the environment. In this work we describe a context-dependent, dynamic mapping between the interfaces of the components being adapted, overcoming some of the limitations ...
Tópico(s): Service-Oriented Architecture and Web Services
2007 - Elsevier BV | Electronic Notes in Theoretical Computer Science
Javier Cámara, Carlos Canal, Javier Cubo, Antonio Vallecillo,
Industry standards for Web Service composition, such as WSBPEL, provide the notation and additional control mechanisms for the execution of business processes in Web Service collaborations. However, these standards do not provide support for checking interesting properties related to Web Service and process behaviour. In an attempt to fill this gap, we describe a formalization of WSBPEL business processes, that adds protocol information to the specifications of interacting Web Services, and uses ...
Tópico(s): Advanced Software Engineering Methodologies
2006 - Elsevier BV | Electronic Notes in Theoretical Computer Science
Patrícia Morales, Isabel C.F.R. Ferreira, Ana Maria Carvalho, María de Cortes Sánchez‐Mata, Montaña Cámara, Javier Tardío,
Polyunsaturated fatty acids play an important role in human nutrition, being associated with several health benefits. The analyzed vegetables, in spite of its low fat content, lower than 2%, present a high proportion of polyunsaturated fatty acids of n-3, n-6 and n-9 series, such as α-linolenic, linoleic and oleic acids, respectively. Wild edible plants contain in general a good balance of n-6 and n-3 fatty acids. The present study tries to contribute to the preservation and valorization of traditional ...
Tópico(s): Cholesterol and Lipid Metabolism
2012 - SAGE Publishing | Food Science and Technology International
Patricia García‐Herrera, María de Cortes Sánchez‐Mata, Montaña Cámara, Javier Tardío, Begoña Olmedilla‐Alonso,
Wild vegetables have traditionally been consumed as part of the Mediterranean diet, being valuable sources of nutrients and bioactive compounds. The objective of this work was to analyse the carotenoid content of the edible young shoots of four species (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.) as part of a wider study on the characterisation of the nutritional composition of wild edible plants commonly consumed in Spain. Samples were gathered from ...
Tópico(s): Phytochemicals and Antioxidant Activities
2012 - Wiley | Journal of the Science of Food and Agriculture
Mariana R. Miranda, Melisa Sayé, León A. Bouvier, María de los Milagros Cámara, Javier M. Montserrat, Claudio A. Pereira,
Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate in the adaptation of parasites to different environments. Here, we report that TcAAP3, a member of a Trypanosoma cruzi multigene family of permeases, is a bona fide arginine transporter. Most higher eukaryotic cells incorporate cationic amino acids through a single transporter. In contrast, T. cruzi can recognize and transport cationic amino acids by mono-specific permeases since a 100-fold molar ...
Tópico(s): Biochemical and Molecular Research
2012 - Public Library of Science | PLoS ONE
Gisela Nogales‐Gadea, Inés Consuegra-García, Carlos Rubio-Terrés, Joaquı́n Arenas, Marc Cuadros, Yolanda Cámara, Javier Torres‐Torronteras, Carmen Fiuza‐Luces, Alejandro Lucía, Miguel Á. Martín, Elena García‐Arumí, Antoni L. Andreu,
McArdle disease is caused by lack of glycogen phosphorylase (GP) activity in skeletal muscle. Patients experience exercise intolerance, presenting as early fatigue and contractures. In this study, we investigated the effects produced by a lack of GP on several genes and proteins of skeletal muscle in McArdle patients. Muscle tissue of 35 patients and 7 healthy controls were used to identify abnormalities in the patients' transcriptomic profile using low-density arrays. Gene expression was analyzed ...
Tópico(s): Genetic Neurodegenerative Diseases
2012 - Public Library of Science | PLoS ONE
J. De La Cámara, Javier Rodríguez, Fernando Rotellar, A. Viúdez, Jesús García‐Foncillas, F. Pardo, Ignacio Gil‐Bazo, Á. Chopitea, Salvador Martín‐Algarra,
3593 Background: Although surgical resection remains the treatment of choice for liver metastases from colorectal cancer, only a minority of pts are suitable for surgery. Preoperative chemotherapy allows secondary liver resection and subsequent long-term survival in some patients (pts)with unresectable CCR liver metastases Methods: The aim of this study was to evaluate the safety and efficacy of oxaliplatin 120 mg/m2 day 1, CPT-11 150 mg/m2 day 1 and 14, fluorouracil 2600 mg/m2 days 1 and 14 and ...
Tópico(s): Lung Cancer Treatments and Mutations
2004 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Eduardo Sánchez-Bermejo, Gabriel Castrillo, Bárbara del Llano, Cristina Navarro, S. Zarco-Fernández, Dannys Jorge Martínez-Herrera, Yolanda Leo del Puerto, Riansares Muñoz, Carmen Cámara, Javier Paz‐Ares, Carlos Alonso‐Blanco, Antonio Leyva,
The enormous amount of environmental arsenic was a major factor in determining the biochemistry of incipient life forms early in the Earth’s history. The most abundant chemical form in the reducing atmosphere was arsenite, which forced organisms to evolve strategies to manage this chemical species. Following the great oxygenation event, arsenite oxidized to arsenate and the action of arsenate reductases became a central survival requirement. The identity of a biologically relevant arsenate reductase ...
Tópico(s): Photosynthetic Processes and Mechanisms
2014 - Nature Portfolio | Nature Communications
Brígida María Ruiz‐Rodríguez, Concepción Sánchez‐Moreno, Begoña de Ancos, María de Cortes Sánchez‐Mata, Virginia Fernández-Ruíz, Montaña Cámara, Javier Tardío,
Wild Arbutus unedo L. and Rubus ulmifolius Schott fruits are underutilized sources of valuable bioactive compounds with antioxidant capacity.
Tópico(s): Plant biochemistry and biosynthesis
2014 - EDP Sciences | Fruits
Patrícia Morales, Virginia Fernández-Ruíz, María de Cortes Sánchez‐Mata, Montaña Cámara, Javier Tardío,
Tópico(s): Biochemical Analysis and Sensing Techniques
2014 - Springer Science+Business Media | Food Analytical Methods
Brígida María Ruiz‐Rodríguez, Begoña de Ancos, Concepción Sánchez‐Moreno, Virginia Fernández-Ruíz, María de Cortes Sánchez‐Mata, Montaña Cámara, Javier Tardío,
Introduction . Many underutilized wild fruits have great nutritional and functional potential, providing chemical compounds with biological properties. Materials and methods . In the present work we quantified bioactive compounds such as vitamin C (ascorbic and dehydroascorbic acids), and total phenolic compounds composed mainly of phenolic acids, flavonols and anthocyanins, as well as evaluating the antioxidant capacity through different in vitro tests (Folin-Ciocalteu, ABTS·+, DPPH· and FRAP) in wild ...
Tópico(s): Fungal Biology and Applications
2014 - EDP Sciences | Fruits
Patricia Gracia‐García, Concepción De‐la‐Cámara, Javier Santabárbara, Raúl López‐Antón, Miguel Quintanilla, Tirso Ventura, Guillermo Marcos, Antonio Campayo, Pedro Saz, Constantine G. Lyketsos, António Lobo,
Objective-We test the hypothesis that clinically significant depression, severe depression in particular, increases the risk of Alzheimer's Disease (AD).Design-A longitudinal, three-wave epidemiological enquiry was implemented in a sample of individuals aged ≥55 years (n = 4,803) followed-up at 2.5 years and 4.5 years. Setting-Population-based cohort drawn from the ZARADEMP Project, in Zaragoza, Spain.Participants-Cognitively intact individuals at baseline (n = 3,864).Main outcome measures-Depression was ...
Tópico(s): Stroke Rehabilitation and Recovery
2013 - Elsevier BV | American Journal of Geriatric Psychiatry
David Navarro, Paula Amat, Rafael de la Cámara, Javier López, Lourdes Vázquez, David Serrano, José Nieto, M Rovira, José Luís Piñana, Estela Giménez, Carlos Solano,
Abstract Background. Preemptive antiviral therapy for active cytomegalovirus (CMV) infection in allogeneic stem cell transplant recipients (Allo-SCT) results in overtreatment and a high rate of recurrences. Monitoring of CMV-specific T-cell immunity may help to individualize treatments and minimize these problems. Methods. We conducted a prospective, multicenter, matched comparison-group study to evaluate the efficacy and safety of a novel strategy that consisted of interrupting anti-CMV therapy upon ...
Tópico(s): Polyomavirus and related diseases
2016 - Oxford University Press | Open Forum Infectious Diseases
Daniel Castillo, Matthew Weston, Shaun J. McLaren, Jesús Cámara, Javier Yanci,
The aims of this study were to describe the internal and external match loads (ML) of refereeing activity during official soccer matches and to investigate the relationship among the methods of ML quantification across a competitive season. A further aim was to examine the usefulness of differential perceived exertion (dRPE) as a tool for monitoring internal ML in soccer referees. Twenty field referees (FRs) and 43 assistant referees (ARs) participated in the study. Data were collected from 30 competitive ...
Tópico(s): Sports injuries and prevention
2016 - Human Kinetics | International Journal of Sports Physiology and Performance
Manuel A. Ureña-Cámara, Javier Nogueras-Iso, Javier Lacasta, Francisco Javier Ariza López,
With recent advances in remote sensing, location-based services and other related technologies, the production of geospatial information has exponentially increased in the last decades. Furthermore, to facilitate discovery and efficient access to such information, spatial data infrastructures were promoted and standardized, with a consideration that metadata are essential to describing data and services. Standardization bodies such as the International Organization for Standardization have defined ...
Tópico(s): Data Quality and Management
2018 - Taylor & Francis | International Journal of Geographical Information Science
Erika N. Vega, Patricia García‐Herrera, María Ciudad‐Mulero, Ma Ines Dias, María Cruz Matallana González, Montaña Cámara, Javier Tardío, M. Teresa Aguado, José Pinela, Tânia C. S. P. Pires, Lillian Barros, Virginia Fernández-Ruíz, Patrícia Morales,
Wild edible fruits, neglected by the development of commercial agriculture, have recently aroused as a good source of natural colorants and bioactive compounds. These novel uses could cover the recent demand for healthier foods with functional properties. Prunus avium, Fragaria vesca and Vaccinium myrtillus wild fruits were characterized by individual anthocyanin profile and color CIELAB parameters, as well as phenolic fraction. In addition, some bioactivities were evaluated. In P. avium cyanidin- ...
Tópico(s): Botanical Research and Applications
2023 - Elsevier BV | Food Chemistry
Jon Mikel Picabea, Jesús Cámara, Javier Yanci,
The aims of this study were to: (1) analyze table tennis players’ physical profiles considering and comparing players age categories (i.e., under U12, U14, U16, U20, Senior and Older); and (2) to quantify the correlations among the variables measured by each test. Seventy-one table tennis players (61 men and 10 women, 19.7 ± 11.23 years, 1.65 ± 0.13 m, 59.71 ± 17.72 kg and 21.60 ± 4.22 kg/m2) divided into six age groups, performed a sprint test, forearm isometric strength test, countermovement vertical test, ...
Tópico(s): Sport Psychology and Performance
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Manel Puig‐Domingo, Ignacio Bernabéu, Antonio Picó, Betina Biagetti, Joan Gil, Cristina Álvarez‐Escolá, Mireia Jordà, Montserrat Marqués-Pamies, Berta Soldevila, M. Ángeles Gálvez, Rosa Cámara, Javier Aller, Cristina Lamas, Mónica Marazuela,
The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. Considering this, acromegaly treatment should benefit from personalized medicine therapeutic approach by using biomarkers identifying drug response. Pasireotide has been positioned mostly as a compound to be used in ...
Tópico(s): Adrenal and Paraganglionic Tumors
2021 - Frontiers Media | Frontiers in Endocrinology
Etienne Waleckx, Silvia Pérez-Carrillo, Samuel Chávez-Lazo, Rafael Pasos-Alquicira, María Cámara-Heredia, Jesús Acuña-Lizama, Fernando Collí-Balám, Javier Cámara-Mejía, María Jesús Ramírez-Sierra, Julio Vladimir Cruz-Chan, Miguel Rosado‐Vallado, Santos Vázquez-Narvaez, Rosario Nájera-Vázquez, Sébastien Gourbière, Eric Dumonteil,
Non-domiciliated intrusive triatomine vectors are responsible for a low but significant transmission of Trypanosoma cruzi to humans. Their control is a challenge as insecticide spraying is of limited usefulness, and alternative strategies need to be developed for a sustainable control. We performed a non-randomized controlled trial of an Ecohealth intervention based on window insect screens and community participation to reduce house infestation by Triatoma dimidiata in two rural villages in Yucatan, ...
Tópico(s): Insect symbiosis and bacterial influences
2018 - Public Library of Science | PLoS neglected tropical diseases
Javier Nogueras-Iso, Javier Lacasta, Manuel A. Ureña-Cámara, Francisco Javier Ariza López,
During the last decade, numerous governmental, educational or cultural institutions have launched Open Data initiatives that have facilitated the access to large volumes of datasets on the web. The main way to disseminate this availability of data has been the deployment of Open Data catalogs exposing metadata of these datasets, which are easily indexed by web search engines. Open Source platforms have facilitated enormously the labor of institutions involved in Open Data initiatives, making the ...
Tópico(s): Semantic Web and Ontologies
2021 - Institute of Electrical and Electronics Engineers | IEEE Access
Ana Isabel Del Río García, María José Benimeli Camara, Javier Molina Puerto, José Antonio Bonastre Cano, F. Cases,
Tópico(s): Electrochemical Analysis and Applications
2012 - Elsevier BV | International Journal of Electrochemical Science
Patricia García‐Herrera, María de Cortes Sánchez‐Mata, Montaña Cámara, Javier Tardío, Begoña Olmedilla‐Alonso,
Following publication of the above article (DOI 10.1002/jsfa.5952) in the May 2013 issue of Journal of the Science of Food and Agriculture (93:1692–1698), the authors noted an error in the carotenoid concentrations given due to a calculation error in the conversion, from the original units in lab reports (mg/100 g) to the units requested by this Journal (µg g−1). The authors draw attention to the following errors, for which they apologize: On page 1692, in the Abstract, under ‘Results’, one reads: “Lutein, ...
Tópico(s): Phytochemical Studies and Bioactivities
2014 - Wiley | Journal of the Science of Food and Agriculture
M Rebolé, Daniel Castillo, Jesús Cámara, Javier Yanci,
Los objetivos de este estudio fueron por un lado, describir el rendimiento en una prueba de rendimiento cardiovascular realizada en laboratorio y en otra de esprints repetidos (RSA) en árbitros de fútbol de alto nivel, y por otro lado, analizar la asociación entre los resultados obtenidos en ambas pruebas. Doce árbitros de fútbol de alto nivel (Divisiones 1ª, 2ª y 2ª B, 28,8±5,1 años, 73,2±6,6 kg, 1,8±0,1 m 22,82±1,38 kg·m-2) participaron en el estudio. Los árbitros obtuvieron un consumo máximo de ...
Tópico(s): Cardiovascular Effects of Exercise
2016 - University of Málaga | Revista Iberoamericana de Ciencias de la Actividad Física y el Deporte