Carolina Segura, Mauricio Eraso, Javier Bonilla, Carlos O. Mendivil, Giselle Feliz Santiago, Nicolás Useche, Óscar Bernal-Pacheco, Guillermo A. Monsalve, Laura Sanchez, Enrique Hernández, Maria José Peláez-Jaramillo, Allison A. Cárdenas-Mojica,
Rationale: The optimal modality, intensity, duration, frequency, and dose-response of exercise as a therapy for Parkinson's Disease (PD) are insufficiently understood. Objective: To assess the impact of a high-intensity tandem bicycle program on clinical severity, biomarkers, and functional MRI (fMRI) in PD. Methods: A single-center, parallel-group clinical trial was conducted. Thirteen PD patients aged 65 or younger were divided in two groups: a control group and an intervention group that incorporated ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2020 - Frontiers Media | Frontiers in Neurology
Alba Ruiz‐Gaitán, Jordan Fernández-Pereira, Eulogio Valentı́n, María Ángeles Tormo‐Más, Elena Eraso, Javier Pemán, Piet W. J. de Groot,
The emerging multidrug-resistant pathogenic yeast Candida auris causes life-threatening invasive infections and shows a capacity for hospital transmission that is uncommon in other Candida species. Rapid and accurate diagnosis of C. auris infections is crucial; however, the fungus is frequently misidentified. Here, we present a rapid and easily applicable PCR assay for reliable identification of C. auris by designing primers from unique GPI protein-encoding genes. Specificity of the used primers ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2018 - Elsevier BV | International Journal of Medical Microbiology
Mark Lipson, Anna Szécsényi‐Nagy, Swapan Mallick, Annamária Pósa, Balázs Stégmár, Victoria Keerl, Nadin Rohland, Kristin Stewardson, Matthew Ferry, Megan Michel, Jonas Oppenheimer, Nasreen Broomandkhoshbacht, Éadaoin Harney, Susanne Nordenfelt, Bastien Llamas, Balázs Gusztáv Mende, Kitti Köhler, Krisztián Oross, Mária Bondár, Tibor Marton, Anett Osztás, János Jakucs, Tibor Paluch, Ferenc Horváth, Piroska Csengeri, Judit Koós, Katalin Sebők, Alexandra Anders, Pál Raczky, Judit Regenye, Judit P. Barna, Szilvia Fábián, Gábor Serlegi, Zoltán Toldi, Emese Gyöngyvér Nagy, János Dani, Erika Molnár, György Pálfi, László Márk, Béla Melegh, Zsolt Bánfai, László Domboróczki, Javier Fernández Eraso, José Antonio Mujika Alustiza, Carmen Alonso Fernández, Javier Jiménez Echevarría, Ruth Bollongino, Jörg Orschiedt, Kerstin Schierhold, Harald Meller, Alan Cooper, Joachim Bürger, Eszter Bánffy, Kurt W. Alt, Carles Lalueza‐Fox, Wolfgang Haak, David Reich,
Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants who received a limited amount of admixture from resident hunter-gatherers. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which ...
Tópico(s): Archaeology and ancient environmental studies
2017 - Nature Portfolio | Nature
Ïñigo Olalde, Swapan Mallick, Nick Patterson, Nadin Rohland, Vanessa Villalba‐Mouco, Marina Silva, Katharina Dulias, Ceiridwen J. Edwards, Francesca Gandini, Maria Pala, Pedro Soares, Manuel Ferrando-Bernal, Nicole Adamski, Nasreen Broomandkhoshbacht, Olivia Cheronet, Brendan J. Culleton, Daniel Fernandes, Ann Marie Lawson, Matthew Mah, Jonas Oppenheimer, Kristin Stewardson, Zhao Zhang, Juan Manuel Jimenéz Arenas, Isidro Jorge Toro Moyano, Domingo C. Salazar‐García, Pere Castanyer, Marta Santos, Joaquim Tremoleda i Trilla, Marina Lozano, Pablo García Borja, Javier Fernández Eraso, José Antonio Mujika Alustiza, Cecilio Barroso Ruíz, Francisco Javier Parra Bermúdez, Enrique Viguera, Josep Burch, Neus Coromina, David Vivó i Codina, Artur Cebrià, Josep María Fullola i Pericot, Oreto García Puchol, Juan Ignacio Morales, F. Xavier Oms, Tona Majó, Josep María Vergès, Antònia Díaz-Carvajal, Imma Ollich-Castanyer, F. Javier López-Cachero, Ana María Silva, Carmen Alonso Fernández, Germán Delibes de Castro, Javier Jiménez Echevarría, Adolfo Moreno Márquez, Guillermo Pascual Berlanga, Pablo Ramos‐García, José Ramos Muñoz, Eduardo Vijande Vila, Gustau Aguilella, Ángel Esparza Arroyo, Katina T. Lillios, Jennifer Mack, Javier Velasco Vázquez, A.J. Waterman, Luis Benítez de Lugo Enrich, María Benito Sánchez, Bibiana Agustí, Ferran Grau i Codina, Gabriel de Prado, Almudena Estalrrich, Álvaro Fernández Flores, Clive Finlayson, Geraldine Finlayson, Stewart Finlayson, Francisco Giles Guzmán, Antonio Rosas, Virginia Barciela González, Gabriel García Atiénzar, Mauro S. Hernández Pérez, Armando Llanos, Yolanda Carrión Marco, Isabel Beneyto, David López Serrano, Mario Sanz Tormo, António Carlos Valera, Concepción Blasco, Corina Liesau von Lettow‐Vorbeck, Patricia Ríos Mendoza, Joan Daura, María Jesús de Pedro Michó, Agustín Diez Castillo, Raúl Flores Fernández, Joan Francès i Farré, Rafael Garrido Peña, Victor S. Gonçalves, Elisa Guerra Doce, Ana Mercedes Herrero Corral, Joaquim Juan-Cabanilles, Dani López, Sarah B. McClure, Marta Pérez, Arturo Oliver Foix, Montserrat Sanz, Ana Catarina Sousa, Julio Manuel Vidal Encinas, Douglas J. Kennett, Martin Richards, Kurt W. Alt, Wolfgang Haak, Ron Pinhasi, Carles Lalueza‐Fox, David Reich,
Genomics of the Iberian Peninsula Ancient DNA studies have begun to help us understand the genetic history and movements of people across the globe. Focusing on the Iberian Peninsula, Olalde et al. report genome-wide data from 271 ancient individuals from Iberia (see the Perspective by Vander Linden). The findings provide a comprehensive genetic time transect of the region. Linguistics analysis and genetic analysis of archaeological human remains dating from about 7000 years ago to the present elucidate ...
Tópico(s): Archaeology and ancient environmental studies
2019 - American Association for the Advancement of Science | Science
Unai Caballero, Elena Eraso, Javier Pemán, Guillermo Quindós, Valvanera Vozmediano, Stephan Schmidt, Nerea Jauregizar,
The aims of this study were to characterize the antifungal activity of amphotericin B against Candida auris in a static in vitro system and to evaluate different dosing schedules and MIC scenarios by means of semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation. A two-compartment model consisting of a drug-susceptible and a drug-resistant subpopulation successfully characterized the time-kill data and a modified Emax sigmoidal model best described the effect of the drug. ...
Tópico(s): Synthesis and Biological Evaluation
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Josu Narbarte-Hernández, Eneko Iriarte, Carlos Rad, Carlos Tejerizo, Javier Fernández Eraso, Juan Antonio Quirós Castillo,
Cultural landscapes are the result of human societies interacting with their environment, which is reflected in the onset and evolution of social practices such as settlement and agricultural production. This paper discusses the results of a transdisciplinary research program carried out on the vineyard landscape of the Rioja Alavesa district, one of the main wine-producing regions of Spain, focusing on the deserted village of Torrentejo (Basque Country, Spain). The study of archival records, combined ...
Tópico(s): Medieval Architecture and Archaeology
2019 - Elsevier BV | CATENA
Jaime Gea, M. Carmen Sampedro, Asier Vallejo, Ana Polo‐Díaz, M. Aránzazu Goicolea, Javier Fernández Eraso, Ramón J. Barrio,
Abstract The characterization of ancient lipids from prehistoric sediments ( fumiers ) located in a rock‐selter has been possible after the optimization of an analytical method based on the microwave‐assisted extraction and solid‐phase extraction clean‐up step and a final derivatization step followed by gas chromatography with mass spectrometry. Eight sterols and two bile acids were detected just in the partially burned and unburned layers of the fumiers (animal organic residues deriving from manure/ ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
2017 - Wiley | Journal of Separation Science
Ana Polo‐Díaz, Mónica Alonso Eguíluz, María del Carmen González Ruiz, Sandy Pérez, José Antonio Mujika, Rosa M. Albert, Javier Fernández Eraso,
Tópico(s): Pleistocene-Era Hominins and Archaeology
2016 - Elsevier BV | Quaternary International
Mónica Alonso Eguíluz, Javier Fernández Eraso, Rosa M. Albert,
Tópico(s): Archaeological and Geological Studies
2016 - Springer Science+Business Media | Vegetation History and Archaeobotany
Javier Fernández Eraso, José Antonio Mujika Alustiza, Lydia Zapata-Peña, María José Iriarte Chiapusso, Ana Polo‐Díaz, Pedro Castaños, Antonio Tarriño Vinagre, Sergio Cardoso, Jesús Sesma-Sesma, Jesús García-Gazólaz,
2014 - Elsevier BV | Quaternary International
Juan Rofes, Mari Cruz Zuluaga, Xabier Murelaga, Javier Fernández Eraso, Salvador Bailón, María José Goñi Iriarte, Luis Ángel Ortega Cuesta, Ainhoa Alonso Olazabal,
Abstract The Peña Larga site, a rock shelter on the southern slopes of the Cantabrian cordillera (north Spain), is an archeological deposit covering nearly 4000 years, from the early Neolithic to the middle Bronze Age (Atlantic/Subboreal chronozones). It was used both as a household and as a stable, with a hiatus in the Chalcolithic when it was used as a collective sepulcher. Nearly twenty-eight thousand small vertebrate elements were recovered from its seven stratigraphic units, of which 2553 items ...
Tópico(s): Archaeology and ancient environmental studies
2012 - Cambridge University Press | Quaternary Research
Ana Polo‐Díaz, Javier Fernández Eraso,
Sediments from archaeological deposits can be affected both by human activity and environmental agents after deposition. As a result, physical and chemical alterations can be recognized in the stratigraphical record. This work focuses on characterizing and comparing the post-depositional alterations that have affected prehistoric stall deposits from two neighbouring rockshelters located in the Upper Ebro Basin: Los Husos-II (ca. 4450–3790 cal. BC) and Los Husos-I (ca. 2210–1620 cal. BC). Micromorphological ...
Tópico(s): Archaeology and ancient environmental studies
2009 - Elsevier BV | Quaternary International
Aida Andrades Valtueña, Gunnar U. Neumann, Maria A. Spyrou, Lyazzat Musralina, Franziska Aron, A. Beisenov, Andrey Belinskiy, Kirsten I. Bos, Alexandra Buzhilova, Matthias Conrad, Leyla Djansugurova, Miroslav Dobeš, Michal Ernée, Javier Fernández Eraso, Bruno Frøhlich, Mirosław Furmanek, Agata Hałuszko, Svend Hansen, Éadaoin Harney, Alina Hiß, Alexander Hübner, Felix M. Key, Elmira Khussainova, Еgor Kitov, Alexandra Kitova, Corina Knipper, Denise Kühnert, Carles Lalueza‐Fox, Judith Littleton, Ken Massy, Alissa Mittnik, José Antonio Mujika Alustiza, Ïñigo Olalde, Luka Papac, Sandra Penske, Jaroslav Peška, Ron Pinhasi, David Reich, Sabine Reinhold, Raphaela Stahl, Harald Stäuble, Rezeda I. Tukhbatova, Sergey Vasilyev, Elizaveta Veselovskaya, Christina Warinner, Philipp W. Stockhammer, Wolfgang Haak, Johannes Krause, Alexander Herbig,
Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks of plague and research using ancient DNA could demonstrate that it already affected human populations during the Neolithic. However, the pathogen’s genetic diversity, geographic spread, and transmission dynamics during this early period of Y. pestis evolution are largely unexplored. Here, we describe a set of ancient plague genomes up to 5,000 y old from across Eurasia. Our data demonstrate that two ...
Tópico(s): Forensic and Genetic Research
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Guillermo Quindós, Elena Eraso, Alfonso Javier Carrillo‐Muñoz, Rafael Cantón, Javier Pemán,
Micafungin is a new and very useful pharmacological tool for the treatment of invasive mycoses with a wide antifungal spectrum for the most common pathogenic fungi. Micafungin is especially active against the genera Candida and Aspergillus. Its antifungal mechanism is based on the inhibition of the beta-1,3- D-glucan synthesis, an essential molecule for the cell wall architecture, with different con sequences for Candida and Aspergillus, being micafungin fungicide for the former and fungistatic ...
Tópico(s): Nail Diseases and Treatments
2009 - Elsevier BV | Revista Iberoamericana de Micología
Guillermo Quindós, Alfonso Javier Carrillo‐Muñoz, Elena Eraso, Rafael Cantón, Javier Pemán,
Voriconazol se ha desarrollado para afrontar la necesidad creciente de nuevos y eficaces antifúngicos para tratar las micosis invasoras. Esta revision describe el espectro de actividad in vitro de voriconazol basándose en los datos obtenidos en estudios publicados en los últimos tres años. Esta valoración demuestra que voriconazol tiene un espectro antifúngico muy amplio que engloba a los patógenos fúngicos más comunes frente a los que desarrolla una acción fungistática (Candida) y fungicida contra ...
Tópico(s): Ocular Infections and Treatments
2007 - Elsevier BV | Revista Iberoamericana de Micología
Se documenta la actividad pastoril en La Rioja Alavesa, desde el Neolítico, por el análisis de cuevas redil.
Tópico(s): Medieval Architecture and Archaeology
2016 - University of Navarre | Cuadernos de Arqueología de la Universidad de Navarra
Cristina Marcos‐Arias, Elena Eraso, Lucila Madariaga, Alfonso Javier Carrillo‐Muñoz, Guillermo Quindós,
Tópico(s): Oral health in cancer treatment
2011 - Springer Science+Business Media | Mycopathologia
Luis Octavio Sánchez Vargas, Elena Eraso, Alfonso Javier Carrillo‐Muñoz, José Manuel Aguirre, Luis Alberto Gaitán Cepeda, Guillermo Quindós,
Oral candidiasis is the most prevalent complication in HIV-infected and AIDS patients. Topical antifungal treatment is useful for the initial episodes of oral candidiasis, but most patients suffer more than one episode and fluconazole or itraconazole can help in the management, and voriconazole may represent a useful alternative agent for the treatment of recalcitrant oral and oesophageal candidiasis. The aim of this research was to study the in vitro activity of voriconazole and fluconazole against ...
Tópico(s): HIV/AIDS oral health manifestations
2009 - Wiley | Mycoses
D. Marín, R. García, Javier Eraso Zabalegui, Jorge Urrestarazu, C. Miranda, José Bernardo Royo Díaz, Francisco Javier Abad Zamora, Gonzaga Santesteban García,
Beyond pest resistance, rootstocks significantly influence the performance of grapevine varieties. However, the effect of the rootstock is strongly affected by its interaction with the environment, and it is therefore necessary to evaluate their influence in a particular terroir. With the aim of evaluating the influence of 12 rootstocks on the agronomic performance of 'Syrah' and 'Tempranillo', a trial was established in 2011 and 2012 in Miranda de Arga (Navarra, Spain), under the typical environmental ...
Tópico(s): Fermentation and Sensory Analysis
2019 - Julius Kühn-Institut | Vitis
Marı́a J. Mazón, Francisco Barros, Pilar de la Peña, Juan Francisco Quesada‐Espinosa, Adela Escudero, Ana María Cobo, Samuel Ignacio Pascual Pascual, Eduardo Gutiérrez‐Rivas, Encarna Guillén‐Navarro, Javier Arpa, Pilar Eraso, Francisco Portillo, Jesús Molano,
Tópico(s): Cardiac electrophysiology and arrhythmias
2011 - Elsevier BV | Neuromuscular Disorders
Elena Eraso, Maite Ruesga, María Villar-Vidal, Alfonso Javier Carrillo‐Muñoz, Ana Espinel‐Ingroff, Guillermo Quindós,
ATB Fungus 2 y SensititreYeastOne son métodos comerciales para el estudio de la sensibilidad in vitro de levaduras a los antifúngicos. La concordancia entre estos dos métodos fue evaluada con un total de 133 aislamientos de Candida (60 Candida albicans, 18 Candida dubliniensis, 29 Candida glabrata y 26 Candida krusei). La lectura de las CMIs se realizó para cada método después de 24 h de incubación a 36 ± 1 °C. La reproducibilidad intralaboratorio de ambos métodos fue excelente (≥ 99%). La concordancia ...
Tópico(s): Nail Diseases and Treatments
2008 - Elsevier BV | Revista Iberoamericana de Micología
Mónica Ruíz Alonso, Lydia Zapata, Sebastián Pérez Díaz, José Antonio López Sáez, Javier Fernández Eraso,
This paper presents the combined results of archaeobotanical studies, of both macro-remains (carbonised wood, seeds and fruit) and micro-remains (pollen, spores and non-pollen microfossils), at three sites in Sierra de Cantabria (Basque Country, northern Iberian Peninsula): Peña Larga, Peña Parda and San Cristóbal, dated from the early Neolithic to the Bronze Age (5500–900 cal BC). The main results show that, despite the abundance of deciduous trees, the taxa used as fuel included both deciduous species ( ...
Tópico(s): Cultural Heritage Materials Analysis
2016 - Elsevier BV | Quaternary International
Luis Miguel Martínez Torres, Javier Fernández Eraso, José Antonio Mujika Alustiza, Álvaro Rodríguez Miranda, José Manuel Valle Melón,
La Chabola de la Hechicera , a Neolithic collective tomb which was first used at ca. 3850 B.C., has been re‐excavated for interpretation and stabilization. Information about the sources, handling, and placement of building materials allowed determination of the methods used to construct the dolmen monument. All of the rocks used in the structure are local Miocene sandstones, and the slabs were probably taken directly from the base of natural slopes near the monument. The chamber slabs were not carved, ...
Tópico(s): Medieval Architecture and Archaeology
2014 - Wiley | Geoarchaeology
I. Miranda-Zapico, Elena Eraso, José Luis Hernández-Almaraz, Leire López-Soria, Alfonso Javier Carrillo‐Muñoz, Juan Manuel Hernández-Molina, Guillermo Quindós,
There is scarce information on the clinical relevance and antifungal susceptibility of Candida bracarensis, Candida nivariensis, Candida orthopsilosis and Candida metapsilosis. The objective of this study was to assess the prevalence and in vitro antifungal susceptibility of these cryptic species among 173 blood isolates previously identified as Candida glabrata or Candida parapsilosis at the Hospital of Cruces (Barakaldo, Spain). The survey was extended to 518 clinical isolates from the culture ...
Tópico(s): Nail Diseases and Treatments
2011 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Rocío Múñoz‐Hernández, Antonio J. Vallejo‐Vaz, Ángeles Sánchez Armengol, Rafael Moreno‐Luna, Candela Caballero‐Eraso, Hada C. Macher, José R. Villar, Ana Merino, Javier Castell, Francisco Capote, Pablo Stiefel,
Study objectives This study tries to assess the endothelial function in vivo using flow-mediated dilatation (FMD) and several biomarkers of endothelium formation/restoration and damage in patients with obstructive sleep apnoea (OSA) syndrome at baseline and after three months with CPAP therapy. Design Observational study, before and after CPAP therapy. Setting and Patients We studied 30 patients with apnoea/hypopnoea index (AHI) >15/h that were compared with themselves after three months of CPAP therapy. ...
Tópico(s): Fatty Acid Research and Health
2015 - Public Library of Science | PLoS ONE
Mónica Alonso Eguíluz, Rosa M. Albert, Josep María Vergès, Javier Fernández Eraso,
The use of caves and/or rock shelters as a refugee for herds was a common practice in the Mediterranean area since the early Neolithic. Shepherds move the herds to pastures in higher altitudes, away from the settlements where the animals graze nearby the shelters where livestock is regrouped. Dung and residues produced during the occupation of these shelters were generally heaped and burnt to clean the site and prepare it for new usage, forming a characteristic deposit known as fumier. Fumier deposits ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
2023 - Elsevier BV | Quaternary International
José Manuel Sánchez Losada, Pilar Davila García, Javier Caamaño Eraso,
This article discusses the influence of the airport management on airport fees, focusing on the survival of small airports. The authors explore the convenience of having small airports and the ways to make such airports economically self-sufficient. Their approach combines a reduction in airport costs with strategies that enhance the potential for increasing revenue. The authors present the perspective of airport management in Spain, where the Aena Aeropuertos in the unique airport authority that ...
Tópico(s): Transportation Planning and Optimization
2012 - Fabrizio Serra Editore | Rivista Internazionale di Economia dei Trasporti
Javier Fernández Eraso, Maite García Rojas,
Tópico(s): Pleistocene-Era Hominins and Archaeology
2010 - Institución Príncipe de Viana | Trabajos de Arqueología Navarra
Rafael Cantón, Javier Pemán, Guillermo Quindós, Elena Eraso, I. Miranda-Zapico, María Álvarez, Paloma Merino, Isolina Campos-Herrero, Francesc Marco, Elia Gómez G. de la Pedrosa, Genoveva Yagüe, Remedios Guna, Carmen Íñiguez, Consuelo Miranda, Carmen Pazos, David Velasco,
A 13-month prospective multicenter study including 44 hospitals was carried out to evaluate the epidemiology of Candida parapsilosis complex candidemia in Spain. Susceptibility to amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, caspofungin, and micafungin was tested by the microdilution colorimetric method. A total of 364 C. parapsilosis complex isolates were identified by molecular methods: C. parapsilosis (90.7%), Candida orthopsilosis (8.2%), and ...
Tópico(s): Oral health in cancer treatment
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Francesca Tiziana Cannizzo, Elena Eraso, Pilar A. Ezkurra, María Villar-Vidal, Enrico Bollo, G. Castellá, F. Javier Cabañes, V. Vidotto, Guillermo Quindós,
Malassezia pachydermatis fungemia has been reported in patients receiving parenteral nutrition. Biofilm formation on catheters may be related to the pathogenesis of this mycosis. We investigated the biofilm-forming ability of 12 M. pachydermatis strains using a metabolic activity plate-based model and electronic microscopic evaluation of catheter surfaces. All M. pachydermatis strains developed biofilms but biofilm formation showed variability among the different strains unrelated to their clinical ...
Tópico(s): Fungal Biology and Applications
2007 - Oxford University Press | Medical Mycology