Itziar Otano, Lester Suárez, Javier Dotor, Manuela González-Aparicio, Julien Crettaz, Cristina Olagüe, Africal Vales, José Ignacio Riezu‐Boj, Esther Larrea, Francisco Borrás, Alberto Benito, Rubén Hernández-Alcoceba, Stephan Menne, Jesús Prìeto, Gloria González‐Aseguinolaza,
Regulatory T cells (Treg) play a critical role in the modulation of immune responses to viral antigens in chronic viral hepatitis. Woodchucks (Marmota monax) infected with the woodchuck hepatitis virus (WHV) represent the best animal model for chronic hepatitis B virus (HBV) infection. Examination of intrahepatic and peripheral Treg in uninfected and WHV chronically infected woodchucks showed a significant increase of intrahepatic Treg numbers in chronically infected animals, whereas no differences ...
Tópico(s): Liver physiology and pathology
2012 - Lippincott Williams & Wilkins | Hepatology
Itziar Otano, Arantza Azpilikueta, Javier Glez‐Vaz, Maite Álvarez, José Medina‐Echeverz, Iván Cortés‐Domínguez, Carlos Ortiz‐de‐Solórzano, Peter Ellmark, Sara Fritzell, Gabriela Hernández‐Hoyos, Michelle H. Nelson, María C. Ochoa, Elixabet Bolaños, Doina Cuculescu, Patricia Jáuregui, Sandra Sánchez‐Gregorio, Iñaki Etxeberría, María E. Rodríguez-Ruiz, Miguel F. Sanmamed, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero,
Abstract CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signaling. In this study, side-by-side comparisons show that provision of CD137 costimulation in- ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Nature Portfolio | Nature Communications
Natividad Benito, Juan Carlos Martínez-Pastor, Jaime Lora-Tamayo, Javier Ariza, José Baeza, Joaquín Belzunegui-Otano, Javier Cobo, María-Dolores del-Toro, César G. Fontecha, Lluís Font-Vizcarra, Juan Pablo Horcajada, Laura Morata, Óscar Murillo, Joan M. Nolla, Esmeralda Núñez Cuadros, Carlos Pigrau, María Eugenia Portillo, Dolors Rodríguez-Pardo, Beatriz Sobrino-Díaz, Jesús Saavedra‐Lozano,
Infection of a native joint, commonly referred to as septic arthritis, is a medical emergency because of the risk of joint destruction and subsequent sequelae. Its diagnosis requires a high level of suspicion. These guidelines for the diagnosis and treatment of septic arthritis in children and adults are intended for use by any physician caring for patients with suspected or confirmed septic arthritis. They have been developed by a multidisciplinary panel with representatives from the Bone and Joint ...
Tópico(s): Hematological disorders and diagnostics
2023 - Elsevier BV | Enfermedades infecciosas y microbiologia clinica (English ed )
Carlos Beaumont-Caminos, Clint Jean-Louis, Tomás Belzunegui Otano, Bernabé Fenández-Esain, Javier Martínez-Jarauta, José L. García-Sanchotena,
Tópico(s): Dermatological and Skeletal Disorders
2010 - Elsevier BV | The American Journal of Emergency Medicine
Lucas Minig, Lucas Otaño, Iván Díaz-Padilla, Rafael Álvarez-Gallego, M. G. Patrono, Javier Bernabe,
Tópico(s): Acute Lymphoblastic Leukemia research
2012 - Springer Science+Business Media | Clinical & Translational Oncology
Sergio Escamilla, Raquel Badillos, Joan X. Comella, Montse Solé, Isabel Pérez‐Otaño, Jose Vicente Sanchez Mut, Javier Sáez‐Valero, Inmaculada Cuchillo‐Ibáñez,
Abstract BACKGROUND Synaptic and extrasynaptic distribution of N‐methyl‐D‐aspartate receptors (NMDARs) has not been addressed in the brain from Alzheimer´s disease (AD) subjects, despite their contribution to neurodegeneration. METHODS We have developed a protocol to isolate synaptic and extrasynaptic membranes from controls and AD frontal cortex. We characterized the distribution of the NMDAR subunits GluN2B, GluN2A, GluN1, and GluN3A, as well as post‐translational modifications, such as phosphorylation ...
Tópico(s): Epilepsy research and treatment
2024 - Wiley | Alzheimer s & Dementia
José Sanz, Daniel Paternain, Mikel Galar, Javier Fernández, Diego Reyero, Tomás Belzunegui Otano,
Severe trauma patients are those who have several injuries implying a death risk. Prediction systems consider the severity of these injuries to predict whether the patients are likely to survive or not. These systems allow one to objectively compare the quality of the emergency services of trauma centres across different hospitals. However, even the most accurate existing prediction systems are based on the usage of a single model. The aim of this paper is to combine several models to make the prediction, ...
Tópico(s): Statistical Methods in Epidemiology
2017 - Elsevier BV | Computer Methods and Programs in Biomedicine
Javier Ibáñez, María Trinidad Herrero, Ricardo Insausti, Tomás Belzunegui Otano, T. Tuñón, F. García‐Bragado, L.M. Gonzalo,
The effect of chronic alcoholism in the neuronal nuclear area (karyometry) of the lateral entorhinal cortex at three rostro-caudal levels (rostral, intermediate and caudal) has been studied in 19 alcoholic subjects and in 15 aged-matched controls. Cases were distributed into three groups according to their age (29–44, 45–60 and 61–70 years of age). In the second group (45–60 years), the nuclear size in layers II and III of the caudal entorhinal cortex showed a very significant decrease compared to controls. ...
Tópico(s): Neuroscience and Neuropharmacology Research
1995 - Elsevier BV | Neuroscience Letters
Itziar Otano, Arantza Azpilikueta, Javier Glez‐Vaz, Peter Ellmark, Sara Fritzell, Gabriela Fernandez-Hoyos, Michelle H. Nelson, Maite Álvarez, María del Carmen Ochoa, Elixabet Bolaños, Doina Cuculescu, Patricia Jáuregui, Sandra Sánchez, Iñaki Etxeberría, María E. Rodríguez-Ruiz, Miguel F. Sanmamed, Álvaro Teijeira, Pedro Berraondo, Igancio Melero,
... in cis or in trans. Citation Format: Itziar Otano, Arantza Azpilikueta, Javier Glez-Vaz, Peter Ellmark, Sara Fritzell, Gabriela Fernandez- ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - American Association for Cancer Research | Cancer Research
Georgina Arrambide, Miguel Ángel Llaneza-González, Lucienne Costa‐Frossard, Virginia Meca‐Lallana, Eva Fernández-Díaz, Irene Moreno‐Torres, José Manuel García‐Domínguez, G. Ortega-Suero, Lucía Ayuso‐Peralta, Mayra Gómez‐Moreno, Javier Sotoca, Ana Belén Caminero-Rodríguez, Luís Antônio, Marcial Corujo-Suárez, María Ángeles Otano-Martínez, Francisco Pérez‐Miralles, Virginia Reyes-Garrido, Teresa Ayuso-Blanco, José Balseiro-Gómez, Mercedes Muñoz-Pasadas, Inmaculada Pérez-Molina, C Arnal-Garcia, Angela Domingo‐Santos, C. Guijarro-Castro, C Iñíguez-Martínez, Nieves Téllez Lara, Fernando Castellanos-Pinedo, Tamara Castillo‐Triviño, Debora María Cerdán-Santacruz, Ángel Pérez Sempere, Berta Torres, Amaya Álvarez de Arcaya, Eva Costa Arpín, Eduardo Durán-Ferreras, Marta Fragoso-Martínez, Montserrat González-Platas, Lamberto Landete Pascual, Jorge Millán‐Pascual, Celia Oreja‐Guevara, José Meca-Lallana,
Objective To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. Methods Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID- ...
Tópico(s): Polyomavirus and related diseases
2021 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation
Natividad Benito, Juan Carlos Martínez-Pastor, Jaime Lora-Tamayo, Javier Ariza, José Baeza, Joaquín Belzunegui-Otano, Javier Cobo, María-Dolores del-Toro, César G. Fontecha, Lluís Font-Vizcarra, Juan Pablo Horcajada, Laura Morata, Óscar Murillo, Joan M. Nolla, Esmeralda Núñez Cuadros, Carlos Pigrau, María Eugenia Portillo, Dolors Rodríguez-Pardo, Beatriz Sobrino-Díaz, Jesús Saavedra‐Lozano,
Infection of a native joint, commonly referred to as septic arthritis, is a medical emergency because of the risk of joint destruction and subsequent sequelae. Its diagnosis requires a high level of suspicion. These guidelines for the diagnosis and treatment of septic arthritis in children and adults are intended for use by any physician caring for patients with suspected or confirmed septic arthritis. They have been developed by a multidisciplinary panel with representatives from the Bone and Joint ...
Tópico(s): Hematological disorders and diagnostics
2023 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
José Sanz, Javier Fernández, Humberto Bustince, Carlos Gradín, Mariano Fortún, Tomás Belzunegui Otano,
Survival prediction of poly-trauma patients measure the quality of emergency services by comparing their predictions with the real outcomes.The aim of this paper is to tackle this problem applying C4.5 since it achieves accurate results and it provides interpretable models.Furthermore, we use sampling techniques because, among the 378 patients treated at the Hospital of Navarre, the number of survivals excels that of deaths.Logistic regressions are used in the comparison, since they are an standard ...
Tópico(s): Artificial Intelligence in Healthcare
2016 - Springer Nature | International Journal of Computational Intelligence Systems
Javier Ibáñez, María Trinidad Herrero, Ricardo Insausti, Tomás Belzunegui Otano, L.M. Gonzalo,
The effect of short-term ethanol intoxication in systems implicated in memory and other cognitive functions in rats has been assessed by studying the variation in the karyometry of the neurons in the different layers of the lateral entorhinal cortex. The analysis showed that short-term ethanol consumption produced a reduction in the nuclear area of neurons in layers V and VI, and to a lesser extent, in layers II and III. These results suggest that the deep layers of the entorhinal cortex are more ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1992 - Elsevier BV | Neuroscience Letters
Rémy Verhaeghe, Oscar Elía‐Zudaire, Sergio Escamilla, Javier Sáez‐Valero, Isabel Pérez‐Otaño,
N-methyl-D-aspartate (NMDA) receptor (NMDAR) dysregulation is thought to contribute to impaired cognition and neurodegeneration in a variety of brain disorders. In a recent article, Zhong et al. proposed that deficiency of the NMDAR subunit GluN3A may be a primary pathogenic factor in sporadic Alzheimer´s disease (AD) based on evidence for degenerative excitotoxicity and cognitive impairment in aging mice lacking GluN3A. Because the result appeared to be at odds with earlier work where genetic GluN3A ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2023 - Wiley | Alzheimer s & Dementia
Adam C. Roberts, Javier Díez‐García, Ramona M. Rodriguiz, Icíar P. López, Rafael Luján, Rebeca Martínez-Turrillas, Esther Picó, Maile A. Henson, Danilo Bernardo, Thomas M. Jarrett, Dallis J. Clendeninn, Laura López‐Mascaraque, Guoping Feng, Donald C. Lo, John F. Wesseling, William C. Wetsel, Benjamin D. Philpot, Isabel Pérez‐Otaño,
NR3A is the only NMDA receptor (NMDAR) subunit that downregulates sharply prior to the onset of sensitive periods for plasticity, yet the functional importance of this transient expression remains unknown. To investigate whether removal/replacement of juvenile NR3A-containing NMDARs is involved in experience-driven synapse maturation, we used a reversible transgenic system that prolonged NR3A expression in the forebrain. We found that removal of NR3A is required to develop strong NMDAR currents, ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2009 - Cell Press | Neuron
Itziar Otano, Cristina Olagüe, Lester Suárez, Javier Dotor, María del Mar González, Alberto Benito, Raymond H. Hernandez, Stephan Menne, José Manuel Compaña Prieto, Gloria González‐Aseguinolaza,
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2012 - Elsevier BV | Journal of Hepatology
Matías Luco, Gisela Salas, Alejandro Zavala, Jesica Otaño, Alberto Toso, Aixa Reusmann, Claudia Cannizzaro, Felipe Santelices, Diana Fariña, Pam Lally, Javier Kattan,
Mortality related to CDH is high, but with great variability among centers. There are few studies on patients with this condition born in South America which show poor outcomes. The goal of this study is to present the outcome of CDH in several high-volume quaternary centers in South America, ascertain the factors associated with lower mortality in our population, and compare our outcomes to those of the CDH Study Group (CDHSG).The data from two South American centers were retrospectively analyzed ...
Tópico(s): Esophageal and GI Pathology
2023 - Elsevier BV | Journal of Pediatric Surgery
Ma Teresa Ayuso Blanco, Ma Eugenia Marzo Sola, Tamara Castillo‐Triviño, Gerardo Soriano Hernández, María Ángeles Otano Martínez, María Ángeles López, Ioana Croitoru, Javier Olascoaga Urtaza,
Objetivo. Evaluar la efectividad y seguridad del fingolimod en la practica clinica en las regiones de Navarra, Gipuzkoa y La Rioja. Pacientes y metodos. Estudio retrospectivo y multicentrico de pacientes con esclerosis multiple recurrente tratados con fingolimod, siguiendo la ficha tecnica. Se evaluo la tasa anualizada de brotes (TAB), el porcentaje de pacientes libres de brotes, la discapacidad usando la escala expandida del estado de discapacidad (EDSS) y el porcentaje de pacientes sin lesiones ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2016 - Viguera Publishers | Revista de Neurología
Marcin Javier, Jokerst Clint, Iñigo Insausti, Tomás Belzunegui Otano, F Urtasun,
Purpose of study: Management of the ruptured splenic aneurysms (RSA) has been surgical though endovascular treatment is currently an alternative option with lower morbidity and mortality. Trans-catheter arterial embolization has gained widespread acceptance as the first line treatment of a ruptured aneurysm. To demonstrate that the application of liquid embolic agent (Onyx) can be applied to ruptured splenic aneurysms. Material and methods: A 47-year-old man presented to the emergency department with ...
Tópico(s): Liver Disease and Transplantation
2010 - Elsevier BV | Resuscitation
Sergio Escamilla, Raquel Badillos-Rodríguez, Montse Solé, Joan X. Comella, Isabel Pérez‐Otaño, José V. Sánchez‐Mut, Inmaculada Cuchillo‐Ibáñez, Javier Sáez‐Valero,
Abstract Background The malfunction of NMDA receptors (NMDARs) is believed to play a key role in Alzheimer’s Disease (AD), the most prevalent type of dementia. NMDARs are activated in different ways: activation at synapses leads to synaptic plasticity, while activation outside of synapses causes excitotoxicity, harm to mitochondria, and cell death. The objective of our research is to better understand the distribution of NMDARs in the brain of individuals with AD, specifically focusing on the distinction ...
Tópico(s): Memory and Neural Mechanisms
2023 - Wiley | Alzheimer s & Dementia
Gabriel Guillermo Cases, Gustavo Javier Calinski, Mariana Laura Méndez, Flavia Alejandra Vidal, Lucas Otaño, Gonzalo Mariani, Silvana Figar, María Isabel Giménez,
Fil: Cases, Gabriel Guillermo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Ciudad Universitaria. Unidad de Microanalisis y Metodos Fisicos en Quimica Organica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanalisis y Metodos Fisicos en Quimica Organica; Argentina. Hospital Italiano; Argentina
Tópico(s): Effects and risks of endocrine disrupting chemicals
2018 - Biochemical Federation of the Province of Buenos Aires | Acta bioquímica clínica latinoamericana/Acta bioquímica clínica latinoamericana
KD Hyde, MA Abdel-Wahab, Jafar Abdollahzadeh, Pranami D. Abeywickrama, S Absalan, Naghmeh Afshari, AM Ainsworth, O. Yu. Akulov, VV Aleoshin, Abdullah M. Al‐Sadi, Pablo Alvarado, Artur Alves, Genivaldo Alves-Silva, Mario Amalfi, Yulia Amira, TB Amuhenage, J.G. Anderson, Vladimír Antonín, Souhila Aouali, André Aptroot, CCS Apurillo, João P. M. Araújo, Hiran A. Ariyawansa, A Armand, E Arumugam, Raheleh Asghari, D. P. Assis, V. Atienza, Shubhi Avasthi, Eduardo Bessa Azevedo, AH Bahkali, Mounes Bakhshi, Z. Banihashemi, DF Bao, H-O Baral, Marisa Barata, F. R. Barbosa, RN Barbosa, R.W. Barreto, Christiane Baschien, DB Belamesiatseva, M Bennett Reuel, Ishika Bera, JDP Bezerra, JL Bezerra, DJ Bhat, Chitrabhanu S. Bhunjun, M. Virginia Bianchinotti, Janusz Błaszkowski, Aimée Blondelle, Teun Boekhout, Gregory Bonito, Saranyaphat Boonmee, N Boonyuen, Carlo Bregant, Patrick Buchanan, Digvijayini Bundhun, Gaëtan Burgaud, Treena I. Burgess, Bart Buyck, Milay Cabarroi-Hernández, MES Cáceres, Maria Filomena Caeiro, Lei Cai, MF Cai, Mark S. Calabon, Francisco J. Simões Calaça, M Callalli, JF Cano-Lira, Taimy Cantillo Pérez, Benyi Cao, J.R. Carlavilla, Agostinho Carvalho, RF Castañeda-Ruiz, Lisa A. Castlebury, Oscar Castro-Jauregui, MDV Catania, LH Cavalcanti, Jonathan Cazabonne, ML Cedeño-Sanchez, S Chaharmiri-Dokhaharani, Napalai Chaiwan, Nilanjan Chakraborty, Priscila Chaverrí, Ratchadawan Cheewangkoon, Hubiao Chen, Chun‐Yao Chen, KH Chen, Jie Chen, Qian Chen, Wen‐Hua Chen, YP Chen, KWT Chethana, Claudia Coleine, T. Velasco Conde, MA Corazon-Guivin, Alonso Cortés-Pérez, DH Costa-Rezende, Régis Courtecuisse, JA Crouch, PW Crous, Bao‐Kai Cui, Cui Yy, DKA da Silva, Gladstone Alves da Silva, IR da Silva, R. da Silva, Ana Carla da Silva Santos, DQ Dai, YC Dai, Ulrike Damm, Валерій Дармостук, Zoha Daroodi, Kanad Das, Naveed Davoodian, EA Davydov, MC Dayarathne, Cony Decock, MD de Groot, André De Kesel, Thomas Edison E. dela Cruz, R. D. Lange, G. Delgado, CM Denchev, TT Denchev, NT de Oliveira, Nimali I. de Silva, Francisco Adriano de Souza, Bryn T. M. Dentinger, Bandarupalli Devadatha, José Carmine Dianese, Bálint Dima, AG Diniz, Asha J. Dissanayake, LS Dissanayake, HH Doğan, Mingkwan Doilom, Somayeh Dolatabadi, Wei Dong, ZY Dong, LA Dos Santos, ER Drechsler-Santos, TY Du, Manish Kumar Dubey, Arun Kumar Dutta, Eleonora Egidi, Todd F. Elliott, MS Elshahed, M Erdoğdu, Damien Ertz, Javier Etayo, Evans Hc, Xueling Fan, YG Fan, AG Fedosova, Jack W. Fell, Isabel Fernandes, AL Firmino, Patrícia Oliveira Fiúza, Adam Flakus, CA Fragoso de Souza, Jens C. Frisvad, Sally C. Fryar, Toni Gabaldón, AJ Gajanayake, L. A. Galindo, PB Gannibal, Dania García, SR García-Sandoval, Isaac Garrido‐Benavent, Laura Garzoli, AK Gautam, Zhenyu Ge, DJ Gené, Eleni Gentekaki, Masoomeh Ghobad‐Nejhad, AJ Giachini, Gibertoni Tb, Aristóteles Goés‐Neto, Deecksha Gomdola, AR Gomes de Farias, SP Gorjón, BT Goto, MM Granados-Montero, Gareth Griffith, J.Z. Groenewald, Marizeth Groenewald, Hans‐Peter Grossart, Cécile Gueidan, Ashan Gunarathne, Sugantha Gunaseelan, LFP Gusmão, Alejandra C. Gutierrez, Laura Guzmán‐Dávalos, D Haelewaters, Roy E. Halling, YF Han, KK Hapuarachchi, CB Harder, TC Harrington, T Hattori, MQ He, Shuang‐Hui He, SH He, Rosanne Healy, M Herández-Restrepo, Gabriela Heredia, KT Hodge, María E. Holgado-Rojas, Sinang Hongsanan, Egon Horak, Tsuyoshi Hosoya, Jos Houbraken, SK Huang, Naruemon Huanraluek, JS Hur, VG Hurdeal, VP Hustad, Marco Iotti, Teresa Iturriaga, E Jafar, Przemysław Janik, R.G. Udeni Jayalal, SC Jayasiri, Ruvishika S. Jayawardena, Rajesh Jeewon, GH Jerônimo, AL Jesus, J. Jin, Peter R. Johnston, Ebg Jones, Yogesh Joshi, Alfredo Justo, Patricia Kaishian, Makoto Kakishima, Malarvizhi Kaliyaperumal, G. N. Kang, JC Kang, Omid Karimi, С. И. Карпов, SC Karunarathna, Manfred Kaufmann, Martin Kemler, Kezhocuyi Kezo, Sabin Khyaju, Martín Kirchmair, PM Kirk, MJ Kitaura, Isabell Klawonn, Miroslav Kolařík, Alejandro Kong, Francisco Kuhar, Martin Kukwa, S. Kumar, Ivana Kušan, Carlos Lado, K-H Larsson, KPD Latha, HB Lee, Marco Leonardi, DL Leontyev, AS Lestari, CJY Li, DW Li, H. Li, H-Y Li, Lin Li, QR Li, WL Li, Yi Li, YC Li, CF Liao, Kare Liimatainen, YW Lim, Chuan-Gen Lin, Benedetto Teodoro Linaldeddu, CC Linde, MM Linn, Fang Liu, Jian‐Kui Liu, Ning-Guo Liu, Simin Liu, Shi‐Liang Liu, Liu Xf, XY Liu, Liu Xz, ZB Liu, Li Lu, YZ Lu, Thatsanee Luangharn, JJ Luangsaard, HT Lumbsch, Saisamorn Lumyong, Liang Luo, Ming Luo, Zong-Long Luo,
Guizhou Academy of Agricultural Sciences
M. Alonso Pinedo, M. Acebo García‐Guerrero, Natalia Ojeda del Pozo, Jon García-Ormaza, Javier Peña, Rafael Segarra Echevarría, A. Ugarte Ugarte, L. Martín Otaño, Y. Ballorca Arnáiz, Miguel Fraile,
The objective of the present study was to examine the predictive value of clinical and cognitive -including the cognitive reserve (CR) - variables on the severity of the patient's illness at one year of follow-up. A study was held with 45 patients with first episode psychosis (FEP) from 3 main hospitals in the Basque Country (Spain). All patients underwent cognitive, clinical, and functional assessments at baseline and at 6 months follow-up. The cognitive measures included were: the Stroop test, Vocabulary ...
Tópico(s): Attention Deficit Hyperactivity Disorder
2012 - Cambridge University Press | European Psychiatry
Elena Gómez Domínguez, Esther Molina, Luisa Garcı́a-Buey, Marta Casado, Marina Berenguer, Isabel Conde, Miguel Ángel Simón, Pedro Costa‐Moreira, Guilherme Macedo, Rosa M. Morillas, José Presa, Francisco Jorquera, Javier Ampuero, Jose Manuel Sousa-Martin, Antonio Olveira, Manuel Hernández‐Guerra, Juan Ignacio Arenas, Arsénio Santos, Armando Carvalho, Juan Isidro Úriz Otano, María Luisa Gutiérrez García, Elia Pérez‐Fernández, Conrado Fernández-Rodrı́guez,
Tópico(s): Gallbladder and Bile Duct Disorders
2023 - Elsevier BV | Journal of Hepatology
Maria Elena Laino, Mónica Enguita, Santos Castañeda, J. Loricera, C. Moriano, Carlos I. Lasa, V. Calvo-Río, Javier Narváez, P. Navarro Palomo, I. Casafont-Solé, Josep Font, A. Gallego, I. Carrión Barberà, P. Quiroga Colino, Á. García-Aparicio, J. M. Belzunegui Otano, Montserrat López, J. R. De Dios Jiménez de Aberásturi, Sònia Jiménez Hernández, S. Heredia, Annarita Farina, F. J. Navarro Blasco, R. Ortega Castro, Leonel Pérez, E. Labrador-Sánchez, Valvanera Pinillos, M. C. Ortega de la O, Pedro Castro, J. M. Blanco, M. Paulino Huertas, M. A. Matias de la Mano, C. Peralta-Ginés, S. Garcia-Cirera, Jordi Camins, Ana Urruticoechea‐Arana, Margaret Malone, Paula Jiménez, Eva Pérez‐Pampín, B. Varas, Christine Vazquez, N. Vegas-Revenga, O. Rusinovich, E. Giner, J.R. Lamua-Riazuelo, Vicente Aldasoro,
Background Belimumab (BLM) is a monoclonal antibody that inhibits B-lymphocyte stimulating factor (BlyS) approved as a specific treatment for systemic lupus erythematosus (SLE) in 2011. We present the experience with BLM in a Spanish cohort with more than 460 patients. Objectives To describe demographic characteristics, efficacy and safety of BLM in patients with SLE in Spanish population since its approval. Methods Descriptive, retrospective, multicenter study in patients diagnosed with SLE according to EULAR/ ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2023 - BMJ | Annals of the Rheumatic Diseases
... de la musica, el nombramiento del jesuita Nemesio Otano como maximo responsable de la politica musical en ...
Tópico(s): Media, Journalism, and Communication History
2017 - Jesus Tejada and Universidad de Valencia | Revista Electrónica de LEEME
Tatiana Cobo‐Ibáñez, I. Castellví, A. Pros, Marta Domínguez-Álvaro, Laura Nuño, Julia Martínez‐Barrio, Vega Jovaní, Fredeswinda Romero-Bueno, Esther Ruiz-Lucea, Eva Tomero, Ernesto Trallero‐Araguás, Javier Narváez, Jordi Camins-Fàbregas, Alberto Ruíz-Román, Jesús Loarce-Martos, Susana Holgado Pérez, V Miguel Flores-Rodríguez, Francisca Sivera, C. Merino Argumánez, Antonio Juan-Mas, Irene Altabás‐González, María Martín-López, Joaquín Belzunegui-Otano, Carmen Carrasco Cubero, Mercedes Freire-González, Íñigo Rúa‐Figueroa, Nuria Lozano‐Rivas, Julio David Suarez-Cuba, Olga Martínez‐Augustin, R. Ortega Castro, Patricia Alcocer, Alejandro Gómez‐Gómez, Olga Sánchez‐Pernaute, J. L. Tandaipan, Irene Carrión-Barberà, Chamaida Plasencia‐Rodríguez, Oihane Ibarguengoitia-Barrena, Paola Vidal-Montal, Vera Ortiz-Santamaría, N. Garrido-Puñal, Anne Riveros, Esmeralda Delgado-Frías, Juan Miguel López-Gómez, C. Barbadillo, José María Pego‐Reigosa, B. Joven-Ibáñez, Jesús Alejandro Valero-Jaimes, E. Naveda, Ana Isabel Turrión-Nieves, Daniel Seoane‐Mato, Francisco Javier Prado-Galbarro, María Ángeles Puche-Larrubia,
To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment ...
Tópico(s): Muscle Physiology and Disorders
2025 - BioMed Central | Arthritis Research & Therapy
Jesús T. Sánchez-Costa, Rosendo Bugarín González, E. Fernández-Fernández, M. T. Silva, J. M. Belzunegui Otano, C. Moriano, J. Sanchez-Martin, J. Lluch Pons, I. Calvo, Vicente Aldasoro, Lydia Abásolo, J. Loricera, Alberto Ruiz Román, Santos Castañeda, Patricia Moya, María Jesús García Villanueva, V. A. Navarro Angeles, C. Galisteo, Alejandra Chávez‐Riveros, Jose Andrés Román Ivorra, S. Labrada, Margarida Vasques Rocha, C. L. Iñíguez, María González, C Molina, M. Alcalde Villar, Antonio Juan Más, E. De Miguel, Javier Narváez, Miguel Á. González‐Gay, Noemí Patricia Garrido Puñal, Paula Estrada, Ricardo Blanco,
Background Epidemiological information on Giant Cell Arteritis (GCA) comes mainly from the Scandinavian countries of northern Europe, which show a higher incidence than the countries of southern Europe. GCA clinical manifestations can be divided into cranial, extracranial, and general syndrome. Objectives In a large series of GCA from Spain, we studied a ) the incidence of GCA, b ) clinical manifestations, and c ) comorbidities at the time of disease diagnosis. Methods ARTESER is a retrospective epidemiological ...
Tópico(s): IgG4-Related and Inflammatory Diseases
2022 - BMJ | Annals of the Rheumatic Diseases
Olga Rusinovich Lovgach, Zulema Plaza, M. Fernández Castro, José Rosas, Víctor M. Martínez‐Taboada, Alejandro Olivé, Raúl Menor Almagro, Belén Serrano Benavente, Judit Font Urgelles, Ángel García-Aparicio, Sara Manrique‐Arija, Alberto García-Vadillo, Ruth López‐González, Javier Narváez, Maͣ Beatriz Rodriguez-Lozano, C. Galisteo, Jorge Juan González Martín, Paloma Vela, C. Bohórquez Heras, Celia Erausquin, María Beatriz Paredes-Romero, Leyre Riancho‐Zarrabeitia, S. Melchor Díaz, José María Pego‐Reigosa, S. Heredia, C. Moriano, María Ángeles Blázquez-Cañamero, Paula Estrada Alarcón, Enrique Júdez, Joaquín Belzunegui Otaño, C. Ramos Giráldez, M Alvaro, Fernando Sánchez‐Alonso, José Luís Andreu,
To quantify the mortality risk in a large, well-characterized cohort of Sjögren's disease (SjD) patients and to identify independent predictors of mortality in this population. We included 314 patients diagnosed with SjD according to the 2002 American-European Consensus Group criteria from a prospective, multicenter SjögrenSER-PROS cohort. Detailed data on systemic manifestations, serological markers, disease activity, and mortality was collected after 9 years of follow up. The primary outcome was ...
Tópico(s): Salivary Gland Disorders and Functions
2025 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology