Paula Martínez-Delgado, Serena Lacerenza, Antònia Obrador‐Hevia, María López-Álvarez, José L. Mondaza-Hernández, Elena Blanco‐Alcaina, Paloma Sánchez-Bustos, Nadia Hindi, David S. Moura, Javier Martín‐Broto,
Soft tissue sarcomas (STS) are a rare group of mesenchymal solid tumors with heterogeneous genetic profiles and clinical features. Systemic chemotherapy is the backbone treatment for advanced STS; however, STS frequently acquire resistance to standard therapies, which highlights the need to improve treatments and identify novel therapeutic targets. Increases in the knowledge of the molecular pathways that drive sarcomas have brought to light different molecular alterations that cause tumor initiation ...
Tópico(s): Cancer Diagnosis and Treatment
2020 - Multidisciplinary Digital Publishing Institute | Cells
Nadia Hindi, Irene Carrasco García, Alberto Sánchez-Camacho, Antonio Gutiérrez, J. Peinado, Inmaculada del Rincón, Johanna Benedetti, Pilar Sancho, Paloma Santos, Paloma Sánchez-Bustos, David Marcilla, Victor Encinas-Tobajas, Sara Chacon, Cristóbal Muñoz-Casares, David S. Moura, Javier Martín‐Broto,
Symptomatic control and tumoral shrinkage is an unmet need in advanced soft-tissue sarcoma (STS) patients beyond first-line. The combination of trabectedin and radiotherapy showed activity in a recently reported clinical trial in this setting. This retrospective series aims to analyze our experience with the same regimen in the real-life setting. We retrospectively reviewed advanced sarcoma patients treated with trabectedin concomitantly with radiotherapy with palliative intent. Growth-modulation ...
Tópico(s): Cardiac tumors and thrombi
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Antonio Ríos, A. López‐Navas, P. López Cubillana, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Pedro Gutiérrez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Marco Olivo, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, Pablo Ramírez, Pascual Parrilla,
To analyze the level of understanding of the brain death concept among medical students in universities in Spain.This cross-sectional sociological, interdisciplinary, and multicenter study was performed on 9598 medical students in Spain. The sample was stratified by geographical area and academic year. A previously validated self-reported measure of brain death knowledge (questionnaire Proyecto Colaborativo Internacional Donante sobre la Donación y Transplante de Organos) was completed anonymously ...
Tópico(s): Palliative Care and End-of-Life Issues
2018 - SAGE Publishing | Progress in Transplantation
Antonio Ríos, A. López‐Navas, P. López Cubillana, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Pedro Gutiérrez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, Pablo Ramírez, Pascual Parrilla,
Introduction: Medical students represent a new generation of medical thought, and if they have a favourable attitude towards organ donation this will greatly encourage its promotion.Objective: To analyse the attitude of medical students in Spanish universities towards the donation of their own organs and to determine the factors affecting this attitude.Material and Methods: Type of study: A sociological, interdisciplinary, multicentre, and observational study in Spain. Study population: Students ...
Tópico(s): Grief, Bereavement, and Mental Health
2017 - Taylor & Francis | Ethnicity and Health
Antonio Ríos, A. López‐Navas, P. López Cubillana, Francisco Javier Gómez, Jorge Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Pedro Gutiérrez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, G. Ramis, Pablo Ramírez, Pascual Parrilla,
Research into the transplantation of solid organs from animals (xenotransplantation) is generating interest and curiosity given that this could be a way of resolving the shortage in transplant organs. However, the fact is that currently xenotransplantation is far from becoming a clinical practice.To analyse the attitude of medical students from Spanish universities towards the donation of organs from animals and to determine the factors affecting their attitudes.A sociological, interdisciplinary, ...
Tópico(s): Animal Genetics and Reproduction
2015 - Wiley | Xenotransplantation
Antonio Ríos, A. López‐Navas, P. López Cubillana, Francisco Javier Gómez, Jorge Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, Pilar Sánchez-Gallegos, Pedro Gutiérrez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, Pablo Ramírez, Pascual Parrilla,
AIM:To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this attitude. METHODS:Study type: A sociological, interdisciplinary, multicenter and observational study.Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011.Sample size: A sample of 9598 students stratified by geographical area and academic year.Instrument used to measure attitude: A validated questionnaire ( ...
Tópico(s): Palliative Care and End-of-Life Issues
2016 - Baishideng Publishing Group | World Journal of Gastroenterology
Raquel Lahoz Alonso, P Bailo, María Ángeles César Márquez, José Carlos Sánchez Torres, Javier Ignacio Albericio Portero, Marcelino Sánchez Parrilla, Miguel Ángel Suárez Broto, Luis Rello, Silvia Izquierdo Álvarez,
The presence of microdeletions in the Y-chromosome azoospermia factor (AZF) region (YCMs) is considered the most frequent genetic cause of male infertility along with Klinefelter syndrome. The objective of this study was to investigate the frequencies and type of YCMs in infertile men in Aragon and to analyze the relationship between sex hormones, sperm count and microdeletions in them.Retrospective descriptive study of 644 men who during 2006-2019 were screened for YCMs using YChromStrip (Operón, ...
Tópico(s): Sperm and Testicular Function
2022 - Elsevier BV | Medicina Clínica
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, J. Flores-Medina, J. Carrillo, Á. Sánchez, Pablo Ramírez, Pascual Parrilla,
Religious factors have conditioned the attitude toward organ donation and transplantation (ODT) since the beginning of transplantation, despite the fact that most religions are in favor of transplantation. To assess the impact of religious beliefs of medical students on their attitude toward ODT. Population under study: Medical students in Spanish universities. Study sample: Stratified by geographical area and academic course. Assessment instrument: Attitude ODT questionnaire PCID-DTO-Ríos, anonymous ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2018 - Elsevier BV | Transplantation Proceedings
Antonio Ríos, A. López‐Navas, P. López Cubillana, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Pedro Gutiérrez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Marco Olivo, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, Pablo Ramírez, Pascual Parrilla,
Tópico(s): Dialysis and Renal Disease Management
2016 - Springer Science+Business Media | World Journal of Urology
Javier Martín‐Broto, Nadia Hindi, Antonio López‐Pousa, J. Peinado, Rosa Álvarez, Ana Álvarez-González, Antoîne Italiano, Paul Sargos, Josefina Cruz Jurado, J. Isern, Maria Carmen Dolado, Inmaculada Rincon-Pérez, Paloma Sánchez-Bustos, Antonio Gutiérrez, Cleofé Romagosa, Carlo Morosi, Giovanni Grignani, Marco Gatti, Pablo Luna, I. Alastuey, Andrés Redondo, Belén Belinchón, Jordi Martínez-Serra, Marie‐Pierre Sunyach, Jean‐Michel Coindre, Angelo Paolo Dei Tos, Jesús Romero, Alessandro Gronchi, Jean‐Yves Blay, David S. Moura,
Active therapeutic combinations, such as trabectedin and radiotherapy, offer potentially higher dimensional response in second-line treatment of advanced soft-tissue sarcomas. Dimensional response can be relevant both for symptom relief and for survival.To assess the combined use of trabectedin and radiotherapy in treating patients with progressing metastatic soft-tissue sarcomas.Phase 1 of this nonrandomized clinical trial followed the classic 3 + 3 design, with planned radiotherapy at a fixed dose ...
Tópico(s): Cardiac tumors and thrombi
2020 - American Medical Association | JAMA Oncology
Luis Sánchez‐Guillén, Matteo Frasson, Gianluca Pellino, V. Fornés, José Luis Ramos, Blas Flor‐Lorente, Álvaro García‐Granero, Isabel Blesa Sierra, Luís Miguel Jiménez, Alejandro Moya-Martínez, Eduardo García‐Granero, Rico M. A. Alvarez, Brao M. J. García, Juan Manuel Sánchez González, Mariela Braithwaite, E. Martı ́ Martínez, J.A. Álvarez Pérez, Alejandro Espí, Marta Trallero Anoro, Mónica Millán Scheiding, O. Maseda Díaz, Paula Dujovne Lindenbaum, Andrés Monzón Abad, Manuel Romero Simó, Jordi Escoll Rufino, Marta Santamaría Olabarrieta, José Viñas Martinez, M. Lopez Bañaeres, Isabel Blesa Sierra, Francesc Feliu Villaró, Javier Aguiló Lucía, J. Bargallo Berzosa, Naomi A. Hernandez, F. J. Labrador Vallverdú, Pedro A. Parra Baños, Ramón Farrés, J. Hernandis Villalba, Carlos Álvarez Laso, Sonia Martínez Alcaide, Mónica Alvarado, Ignacio Rey Simó, J. Montero García, Alfonso García Fadrique, V. Aguilella Diago, Javier García Septiem, Javier Garcı́a Garcı́a, Luca Ponchietti, M. S. Carceller Navarro, María Ramos Fernández, Raquel Conde Muíño, Daphne Álvarez, Pablo Menéndez Sánchez, Claus-Peter Bienert, M. T. García Martínez, C. Moreno Muzas, Carlos Pastor Idoate, Alejandro Andicoechea, A. P. Alonso Casado, José Vicente Roig Vila, I. Goded Broto, P Collera, Antonio Arroyo Sebastián,
Tópico(s): Enhanced Recovery After Surgery
2020 - Springer Science+Business Media | International Journal of Colorectal Disease
Sílvia Calabuig-Fariñas, Javier Martín‐Broto, Dolors Sánchez-Izquierdo, A Obrador, Luís Ortega, Antonio Casado, Claudia Valverde, Inés de Torres, Andrés Poveda, Aitziber Ugalde, Ángeles Sala, Rafael Ramos, Luis Miguel Gonzalez de Sande, Ferrán Losa, Núria Laínez, Pablo Luna Fra, Josefina Cruz, Ricardo Cubedo, José Antonio López‐Guerrero,
10532 Background: Resected localized GISTs exhibit a wide range of biological behavior from low to high risk of recurrence. Risk categories (low, intermediate and high) are built from mitotic count, size and location. However, the molecular mechanism related to GIST relapse has not yet been fully clarified. The purpose of this study is to characterize miRNA expression profile in high risk GIST patients for both, recurred and not recurred, and detect those differentially expressed in these two subsets. ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, A. Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, J. Carrillo, Á. Sánchez, L. Martínez‐Alarcón, Pascual Parrilla, Pablo Ramírez,
Health professionals are asked to promote health, especially organ transplantation; however, they do not always have specific training. To analyze information about donation and organ transplantation among Spanish medical students. The population under study is medical students in Spanish universities using the database of the International Donor Collaborative Project, stratified by geographic area and academic year (n = 9275). The instrument used is the attitude questionnaire for organ donation for “ ...
Tópico(s): Grief, Bereavement, and Mental Health
2020 - Elsevier BV | Transplantation Proceedings
José L. Mondaza-Hernández, David S. Moura, María López-Álvarez, Paloma Sánchez-Bustos, Elena Blanco‐Alcaina, Carolina Castilla-Ramirez, Paola Collini, Jose Merino-Garcia, Jorge Zamora, Jaime Carrillo, Roberta Maestro, Nadia Hindi, Jesús García‐Foncillas, Javier Martín‐Broto,
Abstract Background Solitary fibrous tumour (SFT) is a rare mesenchymal malignancy that lacks robust prognostic and predictive biomarkers. Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like modifier, associated with tumour progression, and with poor survival of SFT patients, as previous published by our group. Here, we describe the role of ISG15 in the biology of this rare tumour. Methods ISG15 expression was assessed by immunohistochemistry in tissue microarrays from SFT patients and tested ...
Tópico(s): IgG4-Related and Inflammatory Diseases
2022 - Springer Nature | Cellular and Molecular Life Sciences
Antonio Fernández‐Serra, David S. Moura, María Dolores Sanchez-Izquierdo, Sílvia Calabuig-Fariñas, María López-Álvarez, Andrea Martínez-Martínez, Irene Carrasco-García, Marta Ramírez-Calvo, Elena Blanco‐Alcaina, R. Fernández López, Antònia Obrador‐Hevia, Regina Alemany, Antonio Gutiérrez, Nadia Hindi, Andrés Poveda, José Antonio López‐Guerrero, Javier Martín‐Broto,
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level, and they have been described as being associated with tumor prognosis. Here, miRNA profiling was planned to explore new molecular prognostic biomarkers in localized intestinal high-risk GIST. Paraffin tumor blocks of 14 and 86 patients were used in the discovery and expansion sets, respectively. GeneChip miRNA v3.0 was employed to identify the miRNAs differentially expressed between ...
Tópico(s): Metastasis and carcinoma case studies
2020 - Multidisciplinary Digital Publishing Institute | Cancers
David S. Moura, Paloma Sánchez-Bustos, Antonio Fernández‐Serra, María López-Álvarez, José L. Mondaza-Hernández, Elena Blanco‐Alcaina, Angela Gavilan-Naranjo, Paula Martínez-Delgado, Serena Lacerenza, Paloma Santos-Fernandez, Irene Carrasco-García, Samuel Hidalgo-Ríos, Antonio Gutiérrez, Rafael Ramos, Nadia Hindi, Miguel Tarón, José Antonio López‐Guerrero, Javier Martín‐Broto,
A translational study was designed to analyze the expression of nucleotide excision repair (NER) and homologous recombination (HR) genes as potential predictive biomarkers for trabectedin in soft-tissue sarcoma (STS). This study is part of a randomized phase II trial comparing trabectedin plus doxorubicin versus doxorubicin in advanced STS. Gene expression levels were evaluated by qRT-PCR, while CUL4A protein levels were quantified by immunohistochemistry. Expression levels were correlated with patients’ ...
Tópico(s): Lymphoma Diagnosis and Treatment
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan R. Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, J. Flores-Medina, J. Carrillo, Á. Sánchez, Pablo Ramírez, Pascual Parrilla,
The awareness of organ donation among health professionals is important at the time of transplant promotion. In this sense, the training and awareness of the professionals in training is fundamental.To analyze the differences in the attitude toward organ donation and the factors that condition it among medical students of regions with donation rates >50 donors per million population (pmp) with respect to those with rates 50 donors pmp. Group 2 (n = 2018): university students in regions with 50 donors ...
Tópico(s): Organ and Tissue Transplantation Research
2018 - Elsevier BV | Transplantation Proceedings
María López-Álvarez, Cristina González‐Aguilera, David S. Moura, Paloma Sánchez-Bustos, José L. Mondaza-Hernández, Marta Martín‐Ruíz, Marta Renshaw, Rafael Ramos, Carolina Castilla, Elena Blanco‐Alcaina, Nadia Hindi, Javier Martín‐Broto,
Although the overall survival of advanced soft-tissue sarcoma (STS) patients has increased in recent years, the median progression-free survival is lower than 5 months, meaning that there is an unmet need in this population. Among second-line treatments for advanced STS, eribulin is an anti-microtubule agent that has been approved for liposarcoma. Here, we tested the combination of eribulin with gemcitabine in preclinical models of L-sarcoma. The effect in cell viability was measured by MTS and clonogenic ...
Tópico(s): Cancer Genomics and Diagnostics
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
L. Martínez‐Alarcón, Antonio Ríos, Pedro Gutiérrez, Elena Santainés‐Borredá, Francisco Javier Gómez, María Concepción Agras‐Suarez, Jorge Iriarte, Guillermo A. Cañadas‐De la Fuente, Rafael Herruzo, Bárbara Hurtado‐Pardos, Gerardo Blanco‐Fernández, Carmen Bárcena‐Calvo, Javier Llorca, Catalina Perelló‐Campaner, Ángel Asúnsolo, Juan Manuel Arribas Marín, P. Sánchez, Silvia García‐Mayor, Ana Fernández‐Santander, Nelia Soto‐Ruiz, María Teresa de Jesús, Juan Carlos Navalón, Alberto Lana, Carme Bertran‐Noguer, Lorena Fuentes‐Broto, Maria Pilar Peña-Amaro, Juan Ramón Hernández Hernández, María Herrera, J. Virseda, Rafaela Blanco‐Sánchez, José Yélamos, María Dolores Calvo Sánchez, J.A. Bondía, María Carmen Prado-Laguna, Alberto González‐García, Adelina Martínez-Rodríguez, Pilar Bas‐Sarmiento, Francisco Faus-Gabandé, Alicia Muiños-Álvarez, Loreto Peyró-Gregori, Helena Hernández Martínez, A. López‐Navas, Pascual Parrilla, Pablo Ramírez,
The knowledge acquired during university education about organ donation and transplantation (ODT) decisively influences the information future health professionals transmit. This is important in ODT where the participation of the general public is essential to obtain organs. To determine notions of Spanish medicine and nursing students on ODT and its relationship with attitude toward ODT. and design. We conducted a sociologic, multicenter, and observational study. The population for our study consisted ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2020 - Elsevier BV | Transplantation Proceedings
L. Martínez‐Alarcón, Antonio Ríos, Pedro Gutiérrez, Francisco Javier Gómez, Elena Santainés‐Borredá, María Concepción Agras‐Suarez, Jorge Iriarte, Guillermo A. Cañadas‐De la Fuente, Rafael Herruzo, Bárbara Hurtado‐Pardos, Gerardo Blanco‐Fernández, Carmen Bárcena‐Calvo, Javier Llorca, Catalina Perelló‐Campaner, Ángel Asúnsolo, Juan Manuel Arribas Marín, P. Sánchez, Silvia García‐Mayor, Ana Fernández‐Santander, Nelia Soto‐Ruiz, María Teresa de Jesús, Juan Carlos Navalón, Alberto Lana, Carme Bertran‐Noguer, Lorena Fuentes‐Broto, Maria Pilar Peña-Amaro, Juan Ramón Hernández Hernández, María Herrera, J. Virseda, Rafaela Blanco‐Sánchez, José Yélamos, María Dolores Calvo Sánchez, J.A. Bondía, María Carmen Prado-Laguna, Alberto González‐García, Adelina Martínez-Rodríguez, Pilar Bas‐Sarmiento, Francisco Faus-Gabandé, Alicia Muiños-Álvarez, Loreto Peyró-Gregori, Helena Hernández Martínez, A. López‐Navas, Pascual Parrilla, Pablo Ramírez,
Information provided by health care professionals is crucial to create a climate of social opinion. This is important in organ donation and transplantation (ODT), where the participation of the general public is essential to obtain organs. To determine the attitude toward the Law of Presumed Consent (LPC) among Spanish university students and to analyze their relation with attitude toward ODT. and design. The type of study was a sociologic, multicenter, observational study. The population included ...
Tópico(s): Grief, Bereavement, and Mental Health
2020 - Elsevier BV | Transplantation Proceedings
Raquel Lahoz Alonso, P Bailo, María Ángeles César Márquez, José Carlos Sánchez Torres, Javier Ignacio Albericio Portero, Marcelino Sánchez Parrilla, Miguel Ángel Suárez Broto, Luis Rello Varas, Silvia Izquierdo Álvarez,
The presence of microdeletions in the Y-chromosome azoospermia factor (AZF) region (YCMs) is considered the most frequent genetic cause of male infertility along with Klinefelter syndrome. The objective of this study was to investigate the frequencies and type of YCMs in infertile men in Aragon and to analyze the relationship between sex hormones, sperm count and microdeletions in them. Retrospective descriptive study of 644 men who during 2006–2019 were screened for YCMs using YChromStrip (Operón, ...
Tópico(s): Sperm and Testicular Function
2023 - Elsevier BV | Medicina Clínica (English Edition)
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, L. Martínez‐Alarcón, Alberto Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, A.M. Hernández, Marco Antonio Ayala‐García, J. Flores-Medina, J. Carrillo, Á. Sánchez, Juan José Ruiz‐Manzanera, Pablo Ramírez, Pascual Parrilla,
The involvement of health professionals from their training period is important for the promotion of living liver donation. There are data that indicate that the awareness of living donation is lower in areas with high rates of deceased donation.To analyze the attitude toward living liver donation among Spanish medical students, according to donation rates of their regions.Population under study: Medical students in Spanish universities. Database of the Collaborative International Donor Project, ...
Tópico(s): Grief, Bereavement, and Mental Health
2018 - Elsevier BV | Transplantation Proceedings
Javier Martín‐Broto, Antonio Fernández‐Serra, José Durán, Sílvia Calabuig-Fariñas, Antonio Gutiérrez, Irene Felipe‐Abrio, Dolors Sánchez-Izquierdo, Javier Martínez‐Trufero, Antonio Casado, Andrés Poveda, Luis R. Martinez, Carmen Balañá, Ferrán Losa, Claudia Valverde, Jordi Rubió‐Casadevall, Josefina Cruz, Luis Miguel Gonzalez de Sande, Cristina Tous, Ricardo Cubedo, José Antonio López‐Guerrero,
10524 Background: Risk estimation of recurrence in localized GIST relies on factors as mitosis, size, site or capsule rupture. Recently, genotype has shown to add prognostic value at least in intermediate risk group. Nevertheless, there is a remarkable lack of molecular prognostic variables in localized GIST. We had previously performed miRNA arrays in a subset of localized intestinal GIST comparing relapsed vs no-relapsed patients. We identified let-7e (FC = – 1163.9; p < 0.0001) and miR-550 (FC = +204.2; ...
Tópico(s): Metastasis and carcinoma case studies
2015 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Javier Martin-Broto, MD, PhD; Nadia Hindi, MD; Antonio Lopez-Pousa, MD; Javier Peinado-Serrano, MD; Rosa Alvarez, MD; Ana Alvarez-Gonzalez, MD; Antoine Italiano, MD; Paul Sargos, MD; Josefina Cruz-Jurado, MD; Josep Isern-Verdum, MD; Maria Carmen Dolado, MD; Inmaculada Rincon-Pérez, MD; Paloma Sanchez-Bustos, MSc; Antonio Gutierrez, MD, PhD; Cleofe Romagosa, MD, PhD; Carlo Morosi, MD; Giovanni Grignani, MD; Marco Gatti, ...
Tópico(s): Neuroblastoma Research and Treatments
2020 - American Medical Association | JAMA Oncology
David S. Moura, María López-Álvarez, A. Salinas-Villegas, Paloma Sánchez-Bustos, Nadia Hindi, Mihai Roca, Javier Martín‐Broto,
Background: Eribulin (Halaven®; Eisai Co., Tokyo, Japan) is a synthetic analogue of halichondrin B that was approved for advanced liposarcoma. Eribulin, besides its well stablished cytotoxic activity, induces vascular remodelling and increased tumor perfusion, as well as inhibits pericyte- and endothelial-driven angiogenesis, which could facilitate the distribution of other drugs within the tumor. Altogether, we hypothesize that eribulin and gemcitabine, acting in different cell cycle phases and ...
Tópico(s): Sarcoma Diagnosis and Treatment
2018 - Elsevier BV | Annals of Oncology
Nadia Hindi, Alejandro Falcón, Roberto Lasso, Maria Pilar Sancho Marquez, Inmaculada Sanchez-Simon, Ana Fernández‐Teijeiro, Catalina Márquez-Vega, M. Noguer, Javier Martín‐Broto,
e22509 Background: High-dose methotrexate (HDMTX) is a backbone of systemic therapy of osteosarcoma along with cisplatin and doxorubicin. Children excrete MTX more effectively than adults and on this basis most protocols exclude HDMTX in patients (pts) aged over 40 years. Folinic rescue, hydration and plasma drug concentration are critical in the HDMTX management. Here we review our experience with HDMTX in a series of pts > 40y Methods: Those osteosarcoma pts treated in our institution with chemotherapy ...
Tópico(s): Polyomavirus and related diseases
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
José Antonio López‐Guerrero, Antonio Fernández‐Serra, Sílvia Calabuig-Fariñas, Dolors Sánchez-Izquierdo, A Obrador, José Durán, Luis R. Martinez, Regina Alemany, Javier Martín‐Broto,
10514 Background: Risk classification of gastrointestinal stromal tumors (GISTs) is critical owing to adjuvant systemic treatments with tyrosine kinase inhibitors (TKI). Tumor size, mitotic count, location or tumor rupture are used to assess patient prognosis after surgical resection and have been validated for GIST risk stratification. miRNAs have been involved in the pathogenesis and progression of most tumors. The purpose of this study is to characterize and to validate differentially expressed ...
Tópico(s): Metastasis and carcinoma case studies
2014 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, A. Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, J. Carrillo, Á. Sánchez, L. Martínez‐Alarcón, Pascual Parrilla, Pablo Ramírez,
Despite sensitization of medical students toward the donation of organs, a non-negligible percentage of students are not in favor of donation. To analyze the reasons of Spanish medical students who do not have a favorable attitude toward the donation of their own organs after death. The population under study is medical students in Spanish universities, using the database of the International Donor Collaborative Project, stratified by geographic area and academic year. The questionnaire completion ...
Tópico(s): Ethics in Clinical Research
2020 - Elsevier BV | Transplantation Proceedings
Antonio Ríos, A. López‐Navas, Pedro Gutiérrez, Francisco Javier Gómez, J. Iriarte, Rafael Herruzo, Gerardo Blanco‐Fernández, Javier Llorca, Ángel Asúnsolo, P. Sánchez, Ana Fernández‐Santander, María Teresa de Jesús, A. Lana, Lorena Fuentes‐Broto, Juan Ramón Hernández Hernández, J. Virseda, José Yélamos, J.A. Bondía, J. Carrillo, Á. Sánchez, L. Martínez‐Alarcón, Pascual Parrilla, Pablo Ramírez,
Awareness of organ donation among Spanish doctors and medical students is very positive. However, the emerging group of professionals of non-Spanish nationality studying in Spain has not been analyzed. To analyze the differences in the attitudes toward the different types of donation among medical students, according to their nationality. The population under study is medical students in Spanish universities using the database of the International Collaborative Donor Project, stratified by geographic ...
Tópico(s): Reproductive Health and Technologies
2020 - Elsevier BV | Transplantation Proceedings
Javier Martín‐Broto, Antonio Fernández‐Serra, Antonio Gutiérrez, Irene Felipe‐Abrio, José Durán, Sílvia Calabuig-Fariñas, Dolors Sánchez-Izquierdo, Nadia Hindi, Andrés Poveda, Regina Alemany, José Antonio López‐Guerrero,
e22514 Background: Molecular prognostic factors related to recurrence in localized GIST are still scarce so that this recurrence risk relies on clinical and pathologic factors as mitotic count, size, location and capsule rupture. Our group has previously reported the prognostic relevance for relapse free survival (RFS) of let-7e microRNA in 89 high risk intestinal localized GIST. The median of RFS were 26 (19.5-32.6) vs 50 (24.6-39.7) months for below and above median values of let-7e respectively ( ...
Tópico(s): Gastric Cancer Management and Outcomes
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology