Delphine Périé, Carl‐Éric Aubin, Yvan Petit, Marie Beauséjour, Jean Dansereau, Hubert Labelle,
Study Design. To analyze Boston brace biomechanics, pressure measurements and finite element simulations were done on 12 adolescent idiopathic scoliosis patients. Objectives. The aim was to analyze the Boston brace effectiveness using a finite element model and experimental measurements. Summary of Background Data. There are not very many biomechanical studies of Boston brace effectiveness, and its biomechanical action is not completely understood. Methods. This study was performed on 12 girls with ...
Tópico(s): Spine and Intervertebral Disc Pathology
2003 - Lippincott Williams & Wilkins | Spine
Albert R. Davalos, Misako Kawahara, Gautam Malhotra, Nicholas Schaum, Jiahao Huang, Urvi Ved, Christian Beauséjour, Jean‐Philippe Coppé, Françis Rodier, Judith Campisi,
Cellular senescence irreversibly arrests proliferation in response to potentially oncogenic stress. Senescent cells also secrete inflammatory cytokines such as IL-6, which promote age-associated inflammation and pathology. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, but certain immune cells secrete HMGB1 as an extracellular Alarmin to signal tissue damage. We show that nuclear HMGB1 relocalized to the extracellular milieu in senescent human and mouse cells in culture ...
Tópico(s): Immune cells in cancer
2013 - Rockefeller University Press | The Journal of Cell Biology
Yannick D. Benoit, Mavee Witherspoon, Kristian B. Laursen, Amel Guezguez, Marco Beauséjour, Jean‐François Beaulieu, Steven M. Lipkin, Lorraine J. Gudas,
Colorectal cancer is among the leading causes of cancer death in the USA. The polycomb repressive complex 2 (PRC2), including core components SUZ12 and EZH2, represents a key epigenetic regulator of digestive epithelial cell physiology and was previously shown to promote deleterious effects in a number of human cancers, including colon. Using colon cancer stem cells (CCSC) isolated from human primary colorectal tumors, we demonstrate that SUZ12 knockdown and treatment with DZNep, one of the most potent ...
Tópico(s): Cancer Cells and Metastasis
2013 - Elsevier BV | Experimental Cell Research
Albert R. Davalos, Misako Kawahara, Gautam Malhotra, Nicholas Schaum, Jiahao Huang, Urvi Ved, Christian Beauséjour, Jean‐Philippe Coppé, Françis Rodier, Judith Campisi,
Tópico(s): Advanced Glycation End Products research
2013 - Rockefeller University Press | The Journal of Experimental Medicine
Annie Beauséjour, Karine Auger, Jean St‐Louis, M. Brochu,
Despite an increase of circulatory volume and of renin-angiotensin-aldosterone system (RAAS) activity, pregnancy is paradoxically accompanied by a decrease in blood pressure. We have reported that the decrease in blood pressure was maintained in pregnant rats despite overactivation of RAAS following reduction in sodium intake. The purpose of this study was to evaluate the impact of the opposite condition, e.g., decreased activation of RAAS during pregnancy in the rat. To do so, 0.9% or 1.8% NaCl ...
Tópico(s): Electrolyte and hormonal disorders
2003 - American Physical Society | AJP Heart and Circulatory Physiology
Karine Auger, Annie Beauséjour, M. Brochu, Jean St‐Louis,
Gestation is associated with decreased blood pressure and resistance to the effects of vasoconstrictor agents. A recent study showed that pregnant rats, on increased sodium intake, present physiological changes that resemble those observed in preeclampsia. We investigated the effects of sodium supplementation on reactivity and on potassium and Ca(2+) channel activity in blood vessels during gestation. Sodium supplements, 0.9% or 1.8% NaCl as drinking water, were given to nonpregnant and pregnant ...
Tópico(s): Nitric Oxide and Endothelin Effects
2004 - American Physical Society | AJP Heart and Circulatory Physiology
Annie Beauséjour, Daniel Grenier, Jean‐Paul Goulet, Noëlla Deslauriers,
ABSTRACT Chronic inflammation rather than invasion is characteristic of some forms of superficial candidiasis such as denture stomatitis. We hypothesized that Candida albicans may play a critical role in the pathogenesis of inflammatory lesions observed in chronic candidiasis by activating the proinflammatory cytokine interleukin-1β (IL-1β) from epithelial stores of the precursor. The aim of this study was therefore to demonstrate the proteolytic cleavage and activation of the inactive precursor ...
Tópico(s): Immune Response and Inflammation
1998 - American Society for Microbiology | Infection and Immunity
Nicolas Bailly, Lucien Diotalevi, Marie-Hélène Beauséjour, Éric Wagnac, Jean‐Marc Mac‐Thiong, Yvan Petit,
Background The pathogenesis of the central cord syndrome is still unclear. While there is a consensus on hyperextension as the main traumatic mechanism leading to this condition, there is yet to be consensus in studies regarding the pathological features of the spine (intervertebral disc bulging or ligamentum flavum hypertrophy) that could contribute to clinical manifestations. Methods A comprehensive finite element model of the cervical spine segment and spinal cord was used to simulate high-speed ...
Tópico(s): Spinal Fractures and Fixation Techniques
2020 - Elsevier BV | Clinical Biomechanics
Marie‐Lyne Nault, Marie Beauséjour, Marjolaine Roy‐Beaudry, Jean‐Marc Mac‐Thiong, Jacques A. de Guise, Hubert Labelle, Stefan Parent,
Mini The aim of this prospective cohort study was to improve the prediction of curve progression in AIS. By adding the 3D morphology parameters at first visit, the predictive model explains 65% of the variability. It is one of the greatest advances in the understanding of scoliosis progression in the last 30 years. Study Design. Prospective cohort study. Objective. The objective of the present study was to design a model of AIS progression to predict Cobb angle at full skeletal maturity, based on ...
Tópico(s): Pelvic and Acetabular Injuries
2019 - Lippincott Williams & Wilkins | Spine
Pascal Mputu Mputu, Marie Beauséjour, Andréane Richard‐Denis, Jean‐Marc Mac‐Thiong,
Background Neurological outcomes after traumatic spinal cord injury are variable and depend on patient-, trauma-, and treatment-related factors as well as on spinal cord injury characteristics, imaging, and biomarkers. Objective The aims of the study were to identify and classify the early predictors of neurological outcomes after traumatic spinal cord injury. Data Sources The Medline, PubMed, Embase, and the Cochrane Central Database were searched using medical subject headings. The search was ...
Tópico(s): Trauma Management and Diagnosis
2021 - Lippincott Williams & Wilkins | American Journal of Physical Medicine & Rehabilitation
Jessica Spagnolo, Marie Beauséjour, Marie‐Josée Fleury, Jean-François Clément, Claire Gamache, Carine Sauvé, Lyne Couture, Richard Fleet, Shane Knight, Christine Gilbert, Helen‐Maria Vasiliadis,
Abstract Background There was an increase in self-reported mental health needs during the COVID-19 pandemic in Canada, with research showing reduced access to mental health services in comparison to pre-pandemic levels. This paper explores 1) barriers and facilitating factors associated with mental health service delivery via primary care settings during the first two pandemic waves in Quebec, Canada, and 2) recommendations to addressing these barriers. Methods A qualitative descriptive study design ...
Tópico(s): Mental Health Treatment and Access
2022 - BioMed Central | BMC Primary Care
Jean‐François Groulx, Véronique Giroux, Marco Beauséjour, Salah Boudjadi, Nùria Basora, Julie Carrier, Jean‐François Beaulieu,
The integrin α6 subunit pre-messenger RNA undergoes alternative splicing to generate two different splice variants, named α6A and α6B, having distinct cytoplasmic domains. In the human colonic gland, these splice variants display different patterns of expression suggesting specific functions for each variant. We have previously found an up-regulation of the α6β4 integrin in colon adenocarcinomas as well as an increase in the α6A/α6B ratio, but little is known about the involvement of α6Aβ4 versus ...
Tópico(s): RNA and protein synthesis mechanisms
2014 - Oxford University Press | Carcinogenesis
Annie Beauséjour, Karine Bibeau, J.-C. Lavoie, Jean St‐Louis, M. Brochu,
Tópico(s): Reproductive System and Pregnancy
2006 - Elsevier BV | Placenta
Yann Facchinello, Marie Beauséjour, Andréane Richard‐Denis, Cynthia Thompson, Jean‐Marc Mac‐Thiong,
Predicting the long-term functional outcome after traumatic spinal cord injury (TSCI) is needed to adapt medical strategies and plan an optimized rehabilitation. This study investigates the use of regression trees for the development of predictive models based on acute clinical and demographic predictors. This prospective study was performed on 172 patients hospitalized after TSCI. Functional outcome was quantified using the Spinal Cord Independence Measure (SCIM) collected within the first-year post- ...
Tópico(s): Injury Epidemiology and Prevention
2017 - Mary Ann Liebert, Inc. | Journal of Neurotrauma
Salah Boudjadi, Gérald Bernatchez, Blanche Sénicourt, Marco Beauséjour, Pierre H. Vachon, Julie Carrier, Jean‐François Beaulieu,
Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling that participate in the regulation of cell shape, adhesion, migration, survival and proliferation. The integrin α1β1 is known to be involved in RAS/ERK proliferative pathway activation and plays an important role in fibroblast proliferation. In the small intestine, the integrin α1 subunit is present in the crypt proliferative compartment and absent in the villus. We have recently shown that the integrin ...
Tópico(s): Cancer Cells and Metastasis
2017 - Multidisciplinary Digital Publishing Institute | Cancers
Andréane Richard‐Denis, Marie Beauséjour, Cynthia Thompson, Bich-Han Nguyen, Jean‐Marc Mac‐Thiong,
Accurately predicting functional recovery is an asset for all clinicians and decision makers involved in the care of patients with acute traumatic spinal cord injury (TSCI). Unfortunately, there is a lack of information on the relative importance of significant predictors of global functional outcome. There is also a need for identifying functional predictors that can be timely optimized by the medical and rehabilitation teams throughout the hospitalizations phases. The main objective of this work ...
Tópico(s): Trauma and Emergency Care Studies
2018 - Mary Ann Liebert, Inc. | Journal of Neurotrauma
Marie-Hélène Beauséjour, Éric Wagnac, Pierre‐Jean Arnoux, Jean-Marc Mac Thiong, Yvan Petit,
Abstract Flexion-distraction injuries frequently cause traumatic cervical spinal cord injury (SCI). Post-traumatic instability can cause aggravation of the secondary SCI during patient care. However, there is little information on how the pattern of disco-ligamentous injury affects the SCI severity and mechanism. This study objective was to analyze how posterior disco-ligamentous injuries affect spinal cord compression and stress and strain patterns in the spinal cord during post-traumatic flexion ...
Tópico(s): Trauma Management and Diagnosis
2021 - ASM International | Journal of Biomechanical Engineering
Gabriel Gutman, Mathieu Benoit, Julie Joncas, Marie Beauséjour, Soraya Barchi, Hubert Labelle, Stefan Parent, Jean‐Marc Mac‐Thiong,
Background Context The Boston brace (Bb) is the most widely used brace design to treat adolescent idiopathic scoliosis (AIS). The dynamic SpineCor (SC) brace is prescribed in several scoliosis clinics worldwide, but its effectiveness remains controversial. Purpose The study aimed to compare the treatment effectiveness of SC in patients with AIS treated by the developers of the brace with that of the Bb at a single institution. Study Design/Setting This is a retrospective comparison between a cohort ...
Tópico(s): Pelvic and Acetabular Injuries
2016 - Elsevier BV | The Spine Journal
John A. Naslund, Jodie Dionne‐Odom, Cléonas Junior Destiné, Kristen Jogerst, Redouin Renold Sénécharles, Michelande Jean Louis, Jasmin Desir, Yvette Néptune Ledan, Jude Ronald Beauséjour, Roland Charles, Alice Werbel, Elizabeth A. Talbot, Patrice Joseph, Jean W. Pape, Peter F. Wright,
Objective. In Mozambique, a patient-led Community ART Group model developed by Médecins Sans Frontières improved retention in care and adherence to antiretroviral therapy (ART) among persons with HIV. We describe the adaptation and implementation of this model within the HIV clinic located in the largest public hospital in Haiti's Southern Department. Methods. Our adapted model was named Group of 6. Hospital staff enabled stable patients with HIV receiving ART to form community groups with 4-6 members ...
Tópico(s): HIV/AIDS Impact and Responses
2014 - Hindawi Publishing Corporation | AIDS Research and Treatment
Alireza Roostaee, Amel Guezguez, Marco Beauséjour, Aline Simoneau, Pierre H. Vachon, Émile Lévy, Jean‐François Beaulieu,
Mechanisms that maintain proliferation and delay cell differentiation in the intestinal crypt are not yet fully understood. We have previously shown the implication of histone methylation in the regulation of enterocytic differentiation. In this study, we investigated the role of histone deacetylation as an important epigenetic mechanism that controls proliferation and differentiation of intestinal cells using the histone deacetylase inhibitor suberanilohydroxamic acid (SAHA) on the proliferation ...
Tópico(s): Cancer-related gene regulation
2015 - Wiley | Journal of Cellular Biochemistry
Sylvain Létourneau, Jean‐Sébastien Palerme, Jean‐Sébastien Delisle, Christian Beauséjour, Richard L. Momparler, Denis Cournoyer,
Tópico(s): Polyomavirus and related diseases
2000 - Springer Nature | Cancer Gene Therapy
Gabriel Gutman, Julie Joncas, Jean‐Marc Mac‐Thiong, Marie Beauséjour, Marjolaine Roy‐Beaudry, Hubert Labelle, Stefan Parent,
Study Design. Prospective validation of the Scoliosis Research Society Outcomes Questionnaire French-Canadian version (SRS-22fv) in adolescent patients with spondylolisthesis. Objective. To determine the measurement properties of the SRS-22fv. Summary of Background Data. The SRS-22 is widely used for the assessment of health-related quality of life in adolescent idiopathic scoliosis (AIS) and other spinal deformities. Spondylolisthesis has an important effect on quality of life. The instrument was ...
Tópico(s): Spine and Intervertebral Disc Pathology
2017 - Lippincott Williams & Wilkins | Spine
Marco Beauséjour, Dominique Noël, Sonya Thibodeau, Véronique Bouchard, Charlène Harnois, Jean‐François Beaulieu, Marie‐Josée Demers, Pierre H. Vachon,
In human intestinal epithelial crypt (HIEC) cells, the PI3-K/Akt-1 pathway is crucial for the promotion of cell survival and suppression of anoikis. Class I PI3-K consists of a complex formed by a catalytic (C) and regulatory (R) subunit. Three R (p85α, β, and p55γ) and four C (p110α, β, γ and δ) isoforms are known. Herein, we analyzed the expression of PI3-K isoforms in HIEC cells and determined their roles in cell survival, as well as in the β1 integrin/Fak/Src-mediated suppression of anoikis. We report ...
Tópico(s): Colorectal Cancer Treatments and Studies
2012 - Springer Science+Business Media | APOPTOSIS
Sergio Crespo‐Garcia, Pamela R. Tsuruda, Agnieszka Dejda, Rathi D. Ryan, Frédérik Fournier, S. Chaney, Frédérique Pilon, Taner Dogan, Gaël Cagnone, Priyanka Patel, Manuel Buscarlet, Sonali Dasgupta, Gabrielle Girouard, Surabhi Rao, Ariel M. Wilson, Robert O’Brien, Rachel Juneau, Vera Guber, Alexandre Dubrac, Christian Beauséjour, Scott A. Armstrong, Frédérick A. Mallette, Christopher B. Yohn, Jean‐Sébastien Joyal, Dan Marquess, Pedro J. Beltran, Przemysław Sapieha,
Attenuating pathological angiogenesis in diseases characterized by neovascularization such as diabetic retinopathy has transformed standards of care. Yet little is known about the molecular signatures discriminating physiological blood vessels from their diseased counterparts, leading to off-target effects of therapy. We demonstrate that in contrast to healthy blood vessels, pathological vessels engage pathways of cellular senescence. Senescent (p16INK4A-expressing) cells accumulate in retinas of ...
Tópico(s): Retinal Imaging and Analysis
2021 - Cell Press | Cell Metabolism
Yann Facchinello, Andréane Richard‐Denis, Marie Beauséjour, Cynthia Thompson, Jean‐Marc Mac‐Thiong,
Post hoc analysis of prospectively collected data. Assess the influence of surgical timing on neurological recovery using classification tree analysis in patients sustaining cervical traumatic spinal cord injury. Hôpital du Sacré-Coeur de Montreal 42 patients sustaining cervical SCI were followed for at least 6 months post injury. Neurological status was assessed from the American Spinal Injury Association impairment scale (AIS) and neurological level of injury (NLI) at admission and at follow-up. ...
Tópico(s): Cervical and Thoracic Myelopathy
2018 - Springer Nature | Spinal Cord
Hany Abdel Gawwad Soliman, Marie Beauséjour, Julie Joncas, Marjolaine Roy‐Beaudry, Soraya Barchi, Jean‐Marc Mac‐Thiong, Hubert Labelle, Guy Grimard, Stefan Parent,
Tópico(s): Blood transfusion and management
2019 - Springer Science+Business Media | European Spine Journal
Marco Beauséjour, Sonya Thibodeau, Marie‐Josée Demers, Véronique Bouchard, Rémy Gauthier, Jean‐François Beaulieu, Pierre H. Vachon,
Abstract Background Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differentiation. Therefore, we investigated whether α2β1, α3β1, α5β1, and α6β4 integrins perform differentiation state-specific roles in the suppression of IEC anoikis. Results Human (HIEC, Caco-2/15) IECs were exposed to specific antibodies that block the binding activity of integrin ...
Tópico(s): Immune Response and Inflammation
2013 - Springer Science+Business Media | BMC Cell Biology
Basma Benabdallah, Cynthia Désaulniers-Langevin, Chloé Colas, Yuanyi Li, Guy Rousseau, Jean Guimond, Élie Haddad, Christian Beauséjour,
The safe utilization of induced pluripotent stem cell-derivatives in clinic is tributary to the complete elimination of the risk of forming teratomas after transplantation. The extent by which such a risk exists in immune competent hosts is mostly unknown. Here, using humanized mice reconstituted with fetal hematopoietic stem cells and autologous thymus tissue (Hu-BLT) or following the adoptive transfer of peripheral blood mononuclear cells (PBMCs) (Hu-AT), we evaluated the capacity of immune cells ...
Tópico(s): Renal and related cancers
2019 - Frontiers Media | Frontiers in Immunology
Françis Rodier, Denise P. Muñoz, Robert Teachenor, Victoria Chu, Oanh Lê, Dipa Bhaumik, Jean-Philippe Coppé, Eric Campeau, Christian Beauséjour, Sahn-Ho Kim, Albert R. Davalos, Judith Campisi,
DNA damage can induce a tumor suppressive response termed cellular senescence. Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other proteins and harbor persistent nuclear foci that contain DNA damage response (DDR) proteins. To understand how persistent damage foci differ from transient foci that mark repairable DNA lesions, we identify sequential events that differentiate transient foci from persistent foci, which we term 'DNA segments with chromatin alterations ...
Tópico(s): DNA Repair Mechanisms
2010 - The Company of Biologists | Journal of Cell Science
Jean St‐Louis, Benoît Sicotte, Annie Beauséjour, M. Brochu,
Lowering and increasing sodium intake in pregnant rats evoke opposite changes in renin–angiotensin–aldosterone system (RAAS) activity and are associated with alterations of blood volume expansion. As augmented uterine blood flow during gestation is linked to increased circulatory volume, we wanted to determine if low- and high-sodium intakes affect the mechanical properties and angiotensin II (AngII) responses of the uterine vasculature. Non-pregnant and pregnant rats received a normal sodium (0.22% ...
Tópico(s): Nitric Oxide and Endothelin Effects
2006 - Bioscientifica | Reproduction