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Artigo Acesso aberto Revisado por pares

D. Ross Laybutt, Wendy Hasenkamp, Adam Groff, Shane T. Grey, Jean‐Christophe Jonas, Hideaki Kaneto, Arun Sharma, Susan Bonner‐Weir, Gordon C. Weir,

Ross Laybutt, Wendy Hasenkamp, Adam Groff, Shane Grey, Jean-Christophe Jonas, Hideaki Kaneto, Arun Sharma, Susan Bonner-Weir, and Gordon Weir

Tópico(s): Diabetes Management and Research

2001 - American Diabetes Association | Diabetes

Artigo Acesso aberto Revisado por pares

D. Ross Laybutt, Hideaki Kaneto, Wendy Hasenkamp, Shane T. Grey, Jean‐Christophe Jonas, Dennis C. Sgroi, Adam Groff, Christiane Ferran, Susan Bonner‐Weir, Arun Sharma, Gordon C. Weir,

Hypertrophy is one mechanism of pancreatic β-cell growth and is seen as an important compensatory response to insulin resistance. We hypothesized that the induction of protective genes contributes to the survival of enlarged (hypertrophied) β-cells. Here, we evaluated changes in stress gene expression that accompany β-cell hypertrophy in islets from hyperglycemic rats 4 weeks after partial pancreatectomy (Px). A variety of protective genes were upregulated, with markedly increased expression of the ...

Tópico(s): Diet, Metabolism, and Disease

2002 - American Diabetes Association | Diabetes

Artigo Acesso aberto Revisado por pares

Bruce A. Adams, Elaine Vickers, C. Warby, Min-Kyu Park, Wolfgang Fischer, A. Grey Craig, Jean Rivier, Nancy M. Sherwood,

Multiple forms of GnRH within individual brains may have different functions. However, some vertebrates such as salmonids continue to reproduce even though they have lost or do not express 1 of the 3 forms of GnRH found in most other teleosts. We examined a basal salmonid, lake whitefish, to determine the mechanism by which a reduction in the number of GnRH forms occurs. We identified for the first time 3 distinct GnRHs in a salmonid. One form is novel and is designated whitefish GnRH. The primary ...

Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

2002 - Oxford University Press | Biology of Reproduction

Artigo Acesso aberto Revisado por pares

John Powell, Yonathan Zohar, Abigail Elizur, M Park, Wolfgang Fischer, A. Grey Craig, Jean Rivier, David A. Lovejoy, Nancy M. Sherwood,

Most vertebrate species have more than one form of gonadotropin-releasing hormone (GnRH) in their brains, but it is not clear whether each form has a distinct function. We report that sea bream (Sparus aurata) brains have three forms of GnRH, one of which is described herein and is called sea bream GnRH (sbGnRH). The primary structures of two forms were determined by Edman degradation and mass spectral analysis. The amino acid sequence of sbGnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Ser-Pro-Gly-NH2. The ...

Tópico(s): Reproductive biology and impacts on aquatic species

1994 - National Academy of Sciences | Proceedings of the National Academy of Sciences

Artigo Revisado por pares

James F. F. Powell, Wolfgang Fischer, M. Park, A. Grey Craig, Jean Rivier, S A White, R. C. Francis, Russell D. Fernald, Paul Licht, C. Warby, Nancy M. Sherwood,

GnRH is a decapeptide family with at least nine distinct structures. Vertebrates, except for most placental mammals, have more than one of these GnRH forms within the brain. We report chromatographical and immunological evidence that three forms of GnRH are in the brains of both cichlid (Haplochromis burtoni) and pumpkinseed (Lepomis gibbosus) fishes. We argue that the three forms correspond to those previously described as sea bream GnRH (sbGnRH), chicken GnRH-II and salmon GnRH. In contrast, only ...

Tópico(s): Regulation of Appetite and Obesity

1995 - Elsevier BV | Regulatory Peptides

Artigo Acesso aberto Revisado por pares

Alejandro D. Montaner, Lucas A. Mongiat, Victoria Lux‐Lantos, Min Kyu Park, Wolfgang Fischer, A. Grey Craig, Jean Rivier, David W. Lescheid, David A. Lovejoy, Carlos Libertun, Nancy M. Sherwood, Gustavo M. Somoza,

Rat and hamster brain tissues were used to investigate the possible existence of a follicle stimulating hormone (FSH)-releasing factor with similar characteristics to the lamprey gonadotropin-releasing hormone III (lGnRH-III) form proposed in previous reports. The present studies involved isolation and purification of the molecule by high-performance liquid chromatography (HPLC), identification by radioimmunoassay, sequence analysis by automated Edman degradation, mass spectrometry and examination ...

Tópico(s): Growth Hormone and Insulin-like Growth Factors

2001 - Karger Publishers | Neuroendocrinology

Artigo Revisado por pares

Gregory M. Weber, John Powell, M Park, Wolfgang Fischer, A. Grey Craig, Jean Rivier, Uthairat Na‐Nakorn, Ishwar S. Parhar, Somsri Ngamvongchon, E. Gordon Grau, Nancy M. Sherwood,

Three forms of gonadotropin-releasing hormone (GnRH) are isolated and identified here by chemical sequence analysis for one species of tilapia, Oreochromis niloticus, and by HPLC elution position for a second species of tilapia, O. mossambicus. Of the three GnRH forms in O. mossambicus, chicken GnRH-II (cGnRH-II) and sea bream GnRH (sbGnRH) are present in greater abundance in the brain and pituitary than salmon GnRH (sGnRH). These three native forms of GnRH are shown to stimulate the release of prolactin ( ...

Tópico(s): Aquaculture Nutrition and Growth

1997 - Bioscientifica | Journal of Endocrinology

Artigo Revisado por pares

Roderick McGillis,

... bio) "Behind the baroque of images hides the grey eminence of politics." (Jean Baudrillard) I intend to be unashamedly personal. My ...

Tópico(s): Russian Literature and Bakhtin Studies

1997 - Johns Hopkins University Press | ˜The œLion and the unicorn

Artigo Revisado por pares

Charlotte Grey, Mark Nieuwenhuijsen, Jean Golding,

Several epidemiological studies, particularly from the United States, have suggested health concerns may arise from the chronic exposure of young children to pesticides in their home environment. Most of these studies are retrospective and the available pesticide exposure information is either subject to the problem of recall or derived from surrogate information. Currently, little is known about the extent of pesticide use in homes and gardens in the UK. This was investigated in this study using ...

Tópico(s): Air Quality and Health Impacts

2006 - Elsevier BV | The Science of The Total Environment

Artigo Revisado por pares

Alberto Benchimol, Jean F. Legler, E. Grey Dimond,

I N a PREVIOUS paper’ we reported abnormalities of the indirect carotid tracing in patients with aortic valvular stenosis, and we confirmed some of the findings previously described in the literature.2-12 The described findings, consistently present in all patients with this valvular lesion, consisted of prolonged total ejection time and upstroke time, carotid shudder, low anacrotic notch and an inconspicuous dicrotic notch. At that time we also indicated that 2 of our cases with subaortic stenosis ...

Tópico(s): Congenital heart defects research

1963 - Elsevier BV | The American Journal of Cardiology

Artigo

Arthur A. Grey, S Narasimhan, Jean Robert Brisson, Harry Schachter, J. P. Carver,

High field magnetic resonance spectroscopy has been utilized to deduce the primary structure of the glycopeptides from a human myeloma γ 1 -immunoglobulin G (Tem). The major structures found belong to the biantennary complex class of glycopeptides, with a minor (5%) fraction belonging to the bisected biantennary complex class. In the biantennary class, three structures were present with different residues at the termini of the αMan(1-6) and αMan(1-3) arms: (i) with βGal(1-4) and αNeuNAc(2-6), respectively ( ...

Tópico(s): Monoclonal and Polyclonal Antibodies Research

1982 - Canadian Science Publishing | Canadian Journal of Biochemistry

Artigo Revisado por pares

Stéphane Hamelet, Pierre Gibot, Montse Casas‐Cabanas, D. Bonnin, Clare P. Grey, Jordi Cabana, Jean‐Bernard Leriche, J. Rodrı́guez-Carvajal, Matthieu Courty, Stéphane Levasseur, Philippe Carlach, Michèle van Thournout, Jean‐Marie Tarascon, Christian Masquelier,

The thermal behavior under air of LiFePO4-based powders was investigated through the combination of several techniques such as temperature-controlled X-ray diffraction, thermogravimetric analysis and Mössbauer and NMR spectroscopies. The reactivity with air at moderate temperatures depends on the particle size and leads to progressive displacement of Fe from the core structure yielding nano-size Fe2O3 and highly defective, oxidized LixFeyPO4 compositions whose unit-cell volume decreases dramatically ...

Tópico(s): Advanced Battery Technologies Research

2009 - Royal Society of Chemistry | Journal of Materials Chemistry

Artigo Revisado por pares

Haiyan Chen, Michel Armand, Matthieu Courty, Meng Jiang, Clare P. Grey, Franck Dolhem, Jean‐Marie Tarascon, Philippe Poizot,

The use of lithiated redox organic molecules containing electrochemically active C=O functionalities, such as lithiated oxocarbon salts, is proposed. These represent alternative electrode materials to those used in current Li-ion battery technology that can be synthesized from renewable starting materials. The key material is the tetralithium salt of tetrahydroxybenzoquinone (Li(4)C(6)O(6)), which can be both reduced to Li(2)C(6)O(6) and oxidized to Li(6)C(6)O(6). In addition to being directly synthesized ...

Tópico(s): Transition Metal Oxide Nanomaterials

2009 - American Chemical Society | Journal of the American Chemical Society

Artigo Revisado por pares

Charlotte Grey, Mark Nieuwenhuijsen, Jean Golding,

Tópico(s): Health, Environment, Cognitive Aging

2004 - Elsevier BV | Environmental Research

Artigo Revisado por pares

Wayne D. Kornreich, Robert Galyean, Javier Hernández, A. Grey Craig, Cynthia J. Donaldson, Gayle Yamamoto, Catherine Rivier, Wylie Vale, Jean Rivier,

... structure-activity relationship studyWayne D. Kornreich, Robert Galyean, Jean Francois Hernandez, A. Grey Craig, Cynthia J. Donaldson, Gayle Yamamoto, Catherine Rivier, Wylie Vale, and Jean RivierCite this: J. Med. Chem. 1992, 35, 10, ...

Tópico(s): Stress Responses and Cortisol

1992 - American Chemical Society | Journal of Medicinal Chemistry