Benjamin Lacas, Alexandra Carmel, C. Landais, Stuart J. Wong, Lisa Licitra, Jeffrey Tobias, Barbara Burtness, Maria Grazia Ghi, Ezra E.W. Cohen, Cai Grau, Gregory T. Wolf, Ricardo Hitt, Renzo Corvò, Volker Budach, Shaleen Kumar, Sarbani Ghosh Laskar, Jean‐Jacques Mazeron, Lai‐ping Zhong, W. Dobrowsky, Pirus Ghadjar, C. Fallai, Branko Zakotnik, Atul Sharma, René‐Jean Bensadoun, Maria Grazia Ruo Redda, S. Racadot, George Fountzilas, David M. Brizel, P Rovea, Athanassios Argiris, Zoltán Takácsi Nagy, Ju‐Whei Lee, Catherine Fortpied, Jonathan Harris, Jean Bourhis, Anne Aupérin, Pierre Blanchard, Jean‐Pierre Pignon, David J. Adelstein, M. Alfonsi, Y. Belkacemi, Voichita Bar‐Ad, J. Bernier, Åse Bratland, G. Calais, Brittany Campbell, Jimmy J. Caudell, Sylvie Chabaud, Emmanuel Chamorey, Devendra Chaukar, Kwang Nam Choi, O. Choussy, Laurence Collette, Judith Cruz, Carla Dani, Etienne Dauzier, Arlene A. Forastiere, P. Garaud, V. Grégoire, A. Hackshaw, E. Haddad, Bruce G. Haffty, Aaron R. Hansen, Stefanie Hayoz, Jean-Claude Horiot, Branislav Jeremić, Theodore Karrison, Johannes A. Langendijk, M. Lapeyre, Éric Lartigau, Traci Leong, Quynh‐Thu Le, Patricia Lee, Freddi Lewin, Aihua Lin, Alberto Lopes, Samir Mehta, James Moon, Elizabeth Moyal, Bob-valery Occean, P. Olmi, Roberto Orecchia, Brian O’Sullivan, Jens Overgaard, Claire Petit, Harvey Quon, Giuseppe Sanguineti, Tuvana Satar, John Simes, Christian Simon, Clément Sire, Susanne Staar, C. Stromberger, P. Strojan, Stéphane Temam, David Thomson, A. Timochenko, Valter Torri, Vassilikì Tseroni, Jan B. Vermorken, Everett E. Vokes, John Waldron, Klaus–Dieter Wernecke, Joachim Widder, Björn Zackrisson,
The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy ...
Tópico(s): Cleft Lip and Palate Research
2021 - Elsevier BV | Radiotherapy and Oncology
Samy Cecioni, Susan E. Matthews, Helen Blanchard, Jean‐Pierre Praly, Anne Imberty, Sébastien Vidal,
Under microwave activation, the Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) between an azido-functionalized lactoside and tetra-alkynylated core scaffolds (one porphyrin and three topological conformers of calix[4]arenes) afforded four lactosylated glycoclusters in high yields. The glycoclusters were then evaluated and compared to a monovalent probe as ligands of two lectins: ECA from legume plant Erythrina cristagalli and recombinant human galectin-1. Micromolar inhibition concentrations and ...
Tópico(s): Peptidase Inhibition and Analysis
2012 - Elsevier BV | Carbohydrate Research
Pierre Blanchard, Jean-Pierre Huiban, Antonio Musolesi, Patrick Sevestre,
The aim of this article is to assess the impact of obstacles to innovation on firms’ propensity to innovate. We show that distinguishing between firms that do not innovate because they do not intend to and firms that try but fail or give up because of insurmountable obstacles is key for properly measuring the impact of the barriers to innovation. Estimating an innovation production function on appropriately defined subsamples allows obtaining consistent results, i.e. a significant and negative impact ...
Tópico(s): Corporate Finance and Governance
2012 - Oxford University Press | Industrial and Corporate Change
Mohamad‐Ali Tehfe, Jacques Lalevée, Fabrice Morlet‐Savary, Bernadette Graff, Nicolas Blanchard, Jean‐Pierre Fouassier,
New organic photocatalysts derived from pyrene, anthracene, naphthacene, and pentacene are presented here for the formation of free radicals through a photoredox catalysis. These OPCs can work according to an oxidative cycle in a three component system in combination with diphenyl iodonium salt and a silane or in a reductive cycle in combination with amine and alkyl halide. This OPC behavior is highlighted through an investigation of the associated excited state and redox properties. The free radicals ...
Tópico(s): Photochromic and Fluorescence Chemistry
2012 - American Chemical Society | Macromolecules
Jacques Lalevée, Mohamad‐Ali Tehfe, Fabrice Morlet‐Savary, Bernadette Graff, Frédéric Dumur, Didier Gigmès, Nicolas Blanchard, Jean‐Pierre Fouassier,
Photoredox catalysis is now well-known in organic synthesis for the formation of free radicals under very soft irradiations conditions (e.g. sunlight, household fluorescence or LED bulbs, Xe lamp). This method has been introduced here to the polymer chemistry area to initiate ring opening polymerizations (ROP) or free radical polymerizations (FRP). The present paper will give an up-to date situation of the photocatalyst achievements in FRP and ROP.
Tópico(s): Chemistry and Chemical Engineering
2012 - Swiss Chemical Society | CHIMIA International Journal for Chemistry
Zahid Soomro, Samy Cecioni, Helen Blanchard, Jean‐Pierre Praly, Anne Imberty, Sébastien Vidal, Susan E. Matthews,
Synthetic multivalent glycoclusters show promise as anti-adhesives for the treatment of bacterial infections. Here we report the synthesis of a family of tetravalent galactose and lactose functionalised macrocycles based on the resorcin[4]arene core. The development of diastereoselective synthetic routes for the formation of lower-rim propargylated resorcin[4]arenes and their functionalistion via Cu-catalyzed azide–alkyne click chemistry is described. ELLA binding studies confirm that galactose ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2011 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Mohamad‐Ali Tehfe, Jacques Lalevée, Fabrice Morlet‐Savary, Bernadette Graff, Nicolas Blanchard, Jean‐Pierre Fouassier,
A new organic photocatalyst (9,10-bis[(triisopropylsilyl)ethynyl]anthracene, An-Si) is proposed here for the formation of free radicals under very soft irradiation conditions under air through a photoredox catalysis. It works according to an oxidative cycle that uses the combination of An-Si, a diphenyl iodonium salt along with a silane. This behavior is highlighted through an investigation of its excited state and redox properties. The different chemical intermediates are characterized by ESR experiments. ...
Tópico(s): Photopolymerization techniques and applications
2011 - American Chemical Society | ACS Macro Letters
Pierre Olivier Lang, Moustapha Dramé, Damien Jolly, Jean‐Luc Novella, F. Blanchard, Jean‐Pierre Michel,
Le vieillissement de la population confronte notre société à d’énormes défis dont celui de l’adaptation et de l’organisation de la prise en charge sanitaire et médicopsychosociale des personnes âgées. L’analyse de la cohorte SAFEs, pour « Sujets Âgés Fragiles : Évaluation et suivi », a permis de mieux caractériser les patients âgés ayant des évènements négatifs durant ou au décours de leur hospitalisation. À partir des principaux résultats, une réflexion de fond sur l’adaptation des filières de soins aux ...
Tópico(s): Aging, Elder Care, and Social Issues
2010 - Elsevier BV | La Presse Médicale
Sofia Telitel, Stéphane Schweizer, Fabrice Morlet‐Savary, Bernadette Graff, Théophile Tschamber, Nicolas Blanchard, Jean Pierre Fouassier, Moreno Lelli, Emmanuel Lacôte, Jacques Lalevée,
A procedure for the production of N-heterocyclic carbene–boryl radicals (NHC-BH2•) upon visible light irradiation under soft conditions is presented. New acridine orange (dye)/diphenyl disulfide/NHC–BH3 and dye/sulfonium salt/NHC–BH3 three-component initiating systems are introduced for the efficient visible light photopolymerization of trimethylolpropane triacrylate. The new systems could be extendend to polymerization reactions in water (hydroxyethyl acrylate and hydroxyethyl methyl acrylate), which ...
Tópico(s): Photopolymerization techniques and applications
2012 - American Chemical Society | Macromolecules
Rémy Ricoux, Elodie Girgenti, Hélène Sauriat-Dorizon, Dominique Blanchard, Jean‐Pierre Mahy,
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2002 - Springer Science+Business Media | Journal of Protein Chemistry
Rémy Ricoux, Hélène Sauriat-Dorizon, Elodie Girgenti, Dominique Blanchard, Jean‐Pierre Mahy,
Catalytic antibodies with a metalloporphyrin cofactor or «hemoabzymes», used as models for hemoproteins like peroxidases and cytochrome P450, represent a promising route to catalysts tailored for selective oxidation reactions. A brief overview of the literature shows that until now, the first strategy for obtaining such artificial hemoproteins has been to produce antiporphyrin antibodies, raised against various free-base, N-substituted Sn-, Pd- or Fe-porphyrins. Five of them exhibited, in the presence ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2002 - Elsevier BV | Journal of Immunological Methods
Tópico(s): Archaeology and Historical Studies
2002 - Coimbra University Press | Conimbriga Revista de Arqueologia
José Labarère, Loïc Belle, Magali Fourny, N Genès, Jean‐Marc Lablanche, Didier Blanchard, Jean-Pierre Cambou, Nicolas Danchin,
Background: Despite evidence on the efficacy and safety of percutaneous coronary intervention (PCI) for patients with acute myocardial infarction, it is unclear whether patients admitted to hospitals with on-site PCI facilities (hereinafter, PCI hospitals) have improved outcomes in routine practice. Methods:We compared processes of care, hospital outcomes, and 1-year mortality rate for 1176 consecutive patients admitted to 126 PCI hospitals and 738 patients admitted to 190 non-PCI hospitals in France ...
Tópico(s): Heart Failure Treatment and Management
2007 - American Medical Association | Archives of Internal Medicine
Jean‐Michel Soubeyroux, Jean‐Philippe Vidal, M. Baillon, Michèle Blanchard, Jean-Pierre Céron, L. Franchistéguy, Fabienne Régimbeau, Éric Martin, Jean-Christophe Vincendon,
AbstractEn liaison avec les évènements de sècheresse en Métropole, les applications hydrométéorologiques ont bénéficié ces dernières années des actions de recherche sur la modélisation des bilans hydriques et notamment le développement de la chaîne Safran-Isba-Modcou (SIM) à Météo-France en lien avec ses partenaires hydrologiques. La chaîne SIM est maintenant largement utilisée pour le suivi opérationnel de la ressource en eau en France. Elle a fait l'objet également d'une réanalyse à haute résolution ...
Tópico(s): Hydrology and Watershed Management Studies
2010 - Société hydrotechnique de France | La Houille Blanche
Samy Cecioni, Ruth Lalor, Bertrand Blanchard, Jean‐Pierre Praly, Anne Imberty, Susan E. Matthews, Sébastien Vidal,
Abstract A family of seven topologically isomeric calix[4]arene glycoconjugates was prepared through the synthesis of a series of alkyne‐derivatised calix[4]arene precursors that are suitable for the attachment of sugar moieties by microwave‐assisted copper(I)‐catalysed azide–alkyne cycloaddition (CuAAC). The glycoconjugates thus synthesised comprised one mono‐functionalised derivative, two 1,2‐ or 1,3‐divalent regioisomers, one trivalent and three tetravalent topoisomers in the cone, partial cone ...
Tópico(s): Glycosylation and Glycoproteins Research
2009 - Wiley | Chemistry - A European Journal
Johanna L. Watson, Jeffrey L. Stott, Myra T. Blanchard, Jean‐Pierre Lavoie, W. David Wilson, Laurel J. Gershwin, Dennis W. Wilson,
The alterations in lymphocyte subsets in chronic obstructive pulmonary disease (COPD) in the horse were investigated by using monoclonal antibodies to identify CD3+, CD4+, CD8+, and surface immunoglobulin positive (sIg+) lymphocytes in peripheral blood, bronchoalveolar lavage fluid (BALF), and pulmonary biopsy frozen tissue sections. COPD-affected horses ( n = 5) and normal controls ( n = 5) were sampled prestabling and 14 days poststabling, at which time the COPD-affected horses were exhibiting clinical signs ...
Tópico(s): Exercise and Physiological Responses
1997 - SAGE Publishing | Veterinary Pathology
Jean‐Marc Navenot, Marcello Villanova, Brigitte Lucas-H�ron, Alessandro Malandrini, Dominique Blanchard, Jean‐Pierre Louboutin,
Control of complement deposition on autologous cells is mediated by a group of complement regulatory membrane proteins acting at different levels of the complement cascade. Decay accelerating factor (CD55) prevents the assembly of C3 convertases and CD59 membrane inhibitor of reactive lysis (MIRL) restricts homologous complement lysis by the membrane attack complex of complement (MAC) by inhibition of C5b-8 catalyzed insertion of C9. The aim of this work was to study the eventual expression of CD55 ...
Tópico(s): Hemoglobinopathies and Related Disorders
1997 - Wiley | Muscle & Nerve
F Latron, Dominique Blanchard, Jean‐Pierre Cartron,
The 12E7 murine monoclonal antibody recognizes a protease-sensitive component of human red cells, platelets and lymphocytes which could not be detected on granulocytes. Scatchard analyses indicated that the 125I-labelled antibody binds to 1000, 4000 and 27,000 antigen sites on each red cell, platelet and lymphocyte respectively, with a binding constant ranging from 4 × 10(7) to 9 × 10(7) M-1. The membrane components recognized by the monoclonal antibody were characterized by immunostaining on nitrocellulose ...
Tópico(s): Glycosylation and Glycoproteins Research
1987 - Portland Press | Biochemical Journal
Dominique Blanchard, Jean‐Pierre Cartron, Bernard Fournet, Jean Montreuil, H. van Halbeek, J.F.G. Vliegenthart,
Glycophorin A and B from Cad erythrocyte membranes are the carriers of the blood group Cad determinants.They are characterized by a significant increase in molecular mass, as compared to the corresponding glycophorins from control erythrocytes (Cartron, J.-p., and Blanchard, D. (1982) Biochem.J. 207, 497-504).Lipid-free glycophorin A, purified from Cad red cells, showed an increased GalNAc content in comparison to blood group B, Cad-negative, control cells.Alkaline-borohydride treatment of this Cad ...
Tópico(s): Blood groups and transfusion
1983 - Elsevier BV | Journal of Biological Chemistry
Marie José Prigent, Dominique Blanchard, Jean‐Pierre Cartron,
Membrane receptors for Vicia graminea (Vg) lectin on human red cells were analyzed using deoxycholate lysates obtained from 125I-erythrocyte membranes incubated with a purified lectin immobilized on Sepharose 4B. The glycoproteins (GP) specifically bound to the gel were eluted and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and autoradiography. Using native erythrocytes the results obtained demonstrate that N red cells have exposed Vg receptors located on GPα (synonym glycophorin ...
Tópico(s): Transgenic Plants and Applications
1983 - Elsevier BV | Archives of Biochemistry and Biophysics
Dominique Blanchard, Jean‐Pierre Cartron, P. Rouger, C Salmon,
An unusual glycoprotein variant (Pj) was found inherited through a caucasian family exhibiting atypical N and Nvg blood-group reactivities. Pj erythrocytes are blood-group-MS homozygous and have a normal sialic acid content. On sodium dodecyl sulphate/polyacrylamide-gel electrophoresis the variant contains a new component Pj of 24kDa apparent molecular mass in the monomeric state which is sharply stained by periodic acid/Schiff reagent. Both blood-group-MN (alpha) and -Ss (delta) glycoproteins were ...
Tópico(s): Erythrocyte Function and Pathophysiology
1982 - Portland Press | Biochemical Journal
Renaud Ciappuccini, Nicolas Aide, D. Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Jean-Jacques Michels, E. Babin, Stéphane Bardet,
18F-FDG-PET/CT is a useful tool used to evidence persistent/recurrent disease (PRD) in patients with differentiated thyroid cancer and iodine-refractory lesions. The aim of this study was to compare the diagnostic value at the cervical level of the routine whole-body (WB) acquisition and that of a complementary head and neck (HN) acquisition, performed successively during the same PET/CT study.PET/CT studies combining WB and HN acquisitions performed in 85 consecutive patients were retrospectively ...
Tópico(s): Medical Imaging Techniques and Applications
2016 - Public Library of Science | PLoS ONE
Pierre Blanchard, Jean-Pierre Huiban, Claude Mathieu,
AbstractThis article provides an empirical model of the shadow of death in which the exit probability of a firm depends on the firm's productive performance and the firm's level of sunk costs, which are viewed as barriers to exit. The shadow of death effect is treated by assuming a relationship between the propensity to exit and both the contemporaneous and lagged values of efficiency and sunk costs. To estimate the unobserved productive efficiency, we use the Ackerberg et al. (2006) estimator extended ...
Tópico(s): Economic Growth and Productivity
2014 - Taylor & Francis | Applied Economics
Patrick Barnable, Giulia Calenda, Louise A. Ouattara, Agegnehu Gettie, James Blanchard, Ninochka Jean‐Pierre, Larisa Kizima, Aixa Rodríguez, Ciby J. Abraham, Radhika Menon, Samantha Seidor, Michael L. Cooney, Kevin Roberts, Rhoda Sperling, Michael Piatak, Jeffrey D. Lifson, José A. Fernández-Romero, Thomas M. Zydowsky, Melissa Robbiani, Natalia Teleshova,
To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaques, we evaluated safety and anti-SHIV-RT activity of MZC and related gel formulations ex vivo in macaque mucosal explants. In addition, safety was further evaluated in human ectocervical explants. The gels did not induce mucosal toxicity. A single ex vivo ...
Tópico(s): HIV/AIDS Research and Interventions
2014 - Public Library of Science | PLoS ONE
N. Ratynski, Giovanni Cioni, Linda S. Franck, Yvette Blanchard, Jean‐Pierre Sizun,
The neonatal behavioral observation is an important source of medical information in three domains: 1) assessment of development which can be done with the Assessment of Preterm Infant Behavior, 2) assessment of pain with the analysis of facial expression using validated pain scales such as the Neonatal Facial Coding System, 3) assessment of brain injuries with the Quality Assessment of General Movements. Such a behavioral observation of the newborn using validated tools is a useful complement of ...
Tópico(s): Infant Health and Development
2002 - Elsevier BV | Archives de Pédiatrie
Raphaël Pourcelot, A. Vigan, Kjetil Dohlen, Bastien Rouzé, Jean-François Sauvage, Mona El Morsy, Maxime Abellan Lopez, Mamadou N’Diaye, A. Caillat, Élodie Choquet, G. P. P. L. Otten, A. Abbinanti, Philippe Balard, M. Carbillet, P. Blanchard, Jean‐Pierre Hulin, Étienne Robert,
Imaging faint objects, such as exoplanets or disks, around nearby stars is extremely challenging because host star images are dominated by the telescope diffraction pattern. Using a coronagraph is an efficient solution for removing diffraction but requires an incoming wavefront with good quality to maximize starlight rejection. On the ground, the most advanced exoplanet imagers use extreme adaptive optics (ExAO) systems that are based on a deformable mirror (DM) with a large number of actuators to ...
Tópico(s): Optical Systems and Laser Technology
2021 - EDP Sciences | Astronomy and Astrophysics
Claire Petit, Pierre Blanchard, Jean‐Pierre Pignon, B. Lueza,
This study aimed at applying the restricted mean survival time difference (rmstD) as an absolute outcome measure in a network meta-analysis and comparing the results with those obtained using hazard ratios (HR) from the individual patient data (IPD) network meta-analysis (NMA) on the role of chemotherapy for nasopharyngeal carcinoma (NPC) recently published by the MAC-NPC collaborative group (Meta-Analysis of Chemotherapy [CT] in NPC). Twenty trials (5144 patients) comparing radiotherapy (RT) with or without ...
Tópico(s): Fibroblast Growth Factor Research
2019 - BioMed Central | Systematic Reviews
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T.�C. Chan, Ruey‐Long Hong, Ming‐Yuan Chen, Lei Chen, Wen‐Fei Li, Pei‐Yu Huang, Terence Tan, Roger K.C. Ngan, Guopei Zhu, Hai‐Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L.�W. Kwong, James Moon, Jean Bourhis, Anne Aupérin, Jean‐Pierre Pignon, Pierre Blanchard, Anne Aupérin, Pierre Blanchard, E Benhamou, Jean Bourhis, Alexandra Carmel, Somvilai Chakrabandhu, Anthony T.�C. Chan, Lei Chen, Ming‐Yuan Chen, Qiuyan Chen, Yong Chen, Richard J. Chappell, Cheuk‐Wai Choi, Daniel T. T. Chua, Melvien Lee Kiang Chua, George Fountzilas, Julian P. T. Higgins, Ming Hong, Ruey‐Long Hong, Pei‐Yu Huang, Edwin P. Hui, Chin‐Fu Hsiao, Michael Kam, Georgia-Angeliki Koliou, Dora L.�W. Kwong, Benjamin Lacas, Shu-Chuan Lai, Ka On Lam, Michael LeBlanc, Anne WM Lee, Victor Lee, Wen Fei Li, Yoke Lim, Brigette Ma, Jun Ma, Hai‐Qiang Mai, Frankie Mo, James Moon, Wai Tong Ng, Roger K.C. Ngan, Camille Ollivier, Brian O’Sullivan, Claire Petit, Jean‐Pierre Pignon, Sharon Poh, Gerta Rücker, Jonathan S. T. Sham, Yoke Lim Soong, Ying Sun, Terence Tan, Lin‐Quan Tang, Yuk Tung, Joseph Wee, Xuang Wu, Tingting Xu, Li Zhang, Yuan Zhang, Guopei Zhu,
The meta-analysis of chemotherapy for nasopharynx carcinoma (MAC-NPC) collaborative group previously showed that the addition of adjuvant chemotherapy to concomitant chemoradiotherapy had the highest survival benefit of the studied treatment regimens in nasopharyngeal carcinoma. Due to the publication of new trials on induction chemotherapy, we updated the network meta-analysis.For this individual patient data network meta-analysis, trials of radiotherapy with or without chemotherapy in patients ...
Tópico(s): Head and Neck Surgical Oncology
2023 - Elsevier BV | The Lancet Oncology
Anaïs Colas, Alexandre Baudet, Pierre Le Cann, Olivier Blanchard, Jean‐Pierre Gangneux, Estelle Baurès, Arnaud Florentin,
Previous studies have described the chemical pollution in indoor air of healthcare and care facilities. From these studies, the main objective of this work was to conduct a quantitative health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care facilities (hospitals, dental and general practitioner offices, pharmacies and nursing homes). The molecules of interest were 36 volatile and 13 semi-volatile organic compounds. Several professional exposure ...
Tópico(s): Healthcare and Environmental Waste Management
2022 - Multidisciplinary Digital Publishing Institute | Toxics
Produção Nacional
Revisado por pares
Benjamin Lacas, Jean Bourhis, Jens Overgaard, Qiang Zhang, Vincent Grégoire, Matthew Nankivell, Björn Zackrisson, Z. Szutkowski, Rafał Suwiński, Michael Poulsen, Brian O’Sullivan, Renzo Corvò, Sarbani Ghosh Laskar, C. Fallai, Hideya Yamazaki, W. Dobrowsky, Kwan Ho Cho, Beth M. Beadle, Johannes A. Langendijk, Célia M. Viégas, John Hay, Mohamed Lotayef, Mahesh Parmar, Anne Aupérin, Carla van Herpen, P. Maingon, Andy Trotti, Cai Grau, Jean‐Pierre Pignon, Pierre Blanchard, Pierre Blanchard, Jean Bourhis, Benjamin Lacas, Jean‐Pierre Pignon, Jacques Bernier, Quynh‐Thu Le, Jens Overgaard, Masheh KB Parmar, Andy Trotti, Jai Prakash Agarwal, Anne Aupérin, Kian Ang, Hassan K. Awwad, Almalina Bacigalupo, Harry Bartelink, E Benhamou, Jacques Bernier, Pierre Blanchard, Jean Bourhis, Wilfried Budach, Imjai Chitapanarux, Kwan Ho Cho, Laurence Collette, Renzo Corvò, Carla Dani, Stanley Dische, W. Dobrowsky, James W. Denham, C.M.L. Driessen, C. Fallai, Beth M. Beadle, Sarbani Ghosh Laskar, Sushmita Ghoshal, Cai Grau, Vincent Grégoire, John Hay, Carla van Herpen, A Hliniak, Jørgen Johansen, Claus Andrup Kristiansen, Valentina Krstevska, Benjamin Lacas, Johannes A. Langendijk, M. Lapeyre, Quynh‐Thu Le, Mohamed Lotayef, B. Maciejewski, P. Maingon, Wojciech Michalski, Sung Ho Moon, Per Nilsson, Patrizia Olmi, Matthew Nankivell, Kinji Nishiyama, Brian O’Sullivan, Jens Overgaard, Mahesh Parmar, Jean‐Pierre Pignon, Michael Poulsen, Kunnambath Ramadas, Anupam Rishi, David I. Rosenthal, Giuseppe Sanguineti, Michele I. Saunders, Christian Sire, Krzysztof Składowski, Luís Souhami, Rafał Suwiński, Z. Szutkowski, Nitin Tandon, Harm van Tinteren, Valter Torri, Lee Tripcony, Andy Trotti, Célia M. Viégas, John Waldron, Joachim Widder, Stuart J. Wong, Jonn Wu, Hideya Yamazaki, Björn Zackrisson, Qiang Zhang,
Summary Background The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered ...
Tópico(s): Lung Cancer Treatments and Mutations
2017 - Elsevier BV | The Lancet Oncology