Adam J. Schwarz, Lino Becerra, Jaymin Upadhyay, Julie Anderson, Richard Baumgartner, Alexandre Coimbra, Jeff Evelhoch, Richard Hargreaves, Brigitte Robertson, Smriti Iyengar, J. Tauscher, David Bleakman, David Borsook,
Tópico(s): Functional Brain Connectivity Studies
2011 - Elsevier BV | Drug Discovery Today
Adam J. Schwarz, Lino Becerra, Jaymin Upadhyay, Julie Anderson, Richard Baumgartner, Alexander Coimbra, Jeff Evelhoch, Richard Hargreaves, Brigitte Robertson, Smriti Iyengar, J. Tauscher, David Bleakman, David Borsook,
Functional magnetic resonance imaging (fMRI) experiments are more complex compared with standard radiological imaging, involving additional data streams and hardware along with complex analysis methods. Here, we propose guidelines based around mitigating risks associated with the complexities of the technique at the level of the individual imaging protocol, including workable and effective quality assurance/quality control procedures and rigorous, predefined, analysis pipelines. Our aim is to provide ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2011 - Elsevier BV | Drug Discovery Today
Christoper A. Alarcon‐Ruiz, Zoila Romero-Albino, Percy Soto-Becerra, Jeff Huarcaya-Victoria, Fernando M. Runzer‐Colmenares, Elisa Romani-Huacani, David Villarreal‐Zegarra, Jorge L. Maguiña, Moisés Apolaya-Segura, María Sofía Cuba-Fuentes,
Background: The COVID-19 pandemic significantly impacted the mental and emotional health of the elderly, especially those from low to middle-income countries. However, COVID-19 vaccination may reduce this influence. Therefore, we aimed to estimate the effect of vaccination against COVID-19 on the emotional health of older adults. Methods: We selected a national, random, and stratified sample of non-hospitalized adults aged 60 to 79 years from Peru who intended to receive or had already received the COVID-19 ...
Tópico(s): Optimism, Hope, and Well-being
2023 - Faculty of 1000 | F1000Research
Jordi Rodón, José Alejandro Pérez Fidalgo, Ian E. Krop, Howard A. Burris, Ángel Guerrero‐Zotano, Carolyn D. Britten, Carlos Becerra, Jan H.M. Schellens, Donald Richards, Martin Schüler, Maysa Abu‐Khalaf, Faye M. Johnson, Malcolm Ranson, Jeff Edenfield, Antonio P. Silva, Wolfgang Hackl, Cornelia Quadt, David Demanse, Vincent Duval, José Baselga,
To determine the maximum tolerated dose (MTD) of BEZ235, an oral inhibitor of class I PI3K and mTOR complexes 1 and 2. We performed a phase I/Ib, multicenter, open-label study of oral BEZ235 administered in a continuous daily schedule. The study consisted of two parts: dose-escalation part and safety-expansion part. BEZ235 was administered as a single agent to patients with solid tumors or in combination with trastuzumab for HER2+ advanced breast cancer (aBC). Primary end points were MTD, safety, ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2018 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David C. Perry, Paul Aisen, Arthur W. Toga, Gustavo Jiménez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Arthur W. Toga, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Paul Aisen, Ronald Petersen, Clifford R. Jack, Matt A. Bernstein, Bret Borowski, Jeff Gunter, Matthew L. Senjem, Prashanthi Vemuri, David T. Jones, Kejal Kantarci, Chad Ward, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, William J. Jagust, Susan Landau, John Q. Trojanowki, Leslie M. Shaw, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Virginia Lee, Magdalena Korecka, Michal Figurski, Laurel Beckett, Danielle Harvey, Charles DeCarli, Evan Fletcher, Pauline Maillard, John Olichney, Owen Carmichael, Robert C. Green, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Andrew J. Saykin, Tatiana Foroud, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, John C. Morris, Marc Raichle, David M. Holtzman, John C. Morris, Nigel J. Cairns, Erin Franklin, Lisa Taylor‐Reinwald, Beau M. Ances, David Winkfield, Maria Carroll, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, Lew Kuller, Chester A. Mathis, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Steven M. Paul, Norman Relkin, Gloria Chiang, Michael Z. Lin, Lisa Ravdin, Peter Davies, Marek-Marsel Mesulam, Marek-Marsel Mesulam, Emily Rogalskı, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy Johnson, Peter J. Snyder, Tom Montine, Michael Donohue, Lean Thal, James B. Brewer, Helen Vanderswag, Adam Fleisher, Paul M. Thompson, Ellen Woo, Daniel Silverman, Edmond Teng, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Robert A. Koeppe, Jaimie Ziolkowski, Judith L. Heidebrink, Joanne Lord, Norm Foster, Marilyn Albert, Chiadi U. Onyike, Daniel D’Agostino, Stephanie Kielb, Joseph F. Quinn, Lisa Silbert, Betty Lind, Jeffrey Kaye, Raina Carter, Sara Dolen, Javier Villanueva‐Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Randy Yeh, Daniel Marson, David Geldmacher, Marissa Natelson, Randall Griffith, David Clark, John Brockington, Hillel Grossman, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Martin Sadowski, Mohammed O. Sheikh, Jamika Singleton-Garvin, Anaztasia Ulysse, Mrunalini Gaikwad, P. Murali Doraiswamy, Olga James, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Riham El Khouli, Elizabeth Oates, Gary Conrad, Anton P. Porsteinsson, Kim Martin, Nancy Kowalksi, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Steven Potkin, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Christopher H. van Dyck, Richard E. Carson, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Ntekim E. Oyonumo, Joanne Allard, Olu Ogunlana, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Jerome A. Yesavage, Joy L. Taylor, Steven Chao, Barton Lane, Allyson Rosen, Jared Tinklenberg, Douglas W. Scharre, Maria Kataki, Rawan Tarawneh, Earl A. Zimmerman, Dzintra Celmins, David Hart, Laura A. Flashman, Marc Seltzer, Mary L. Hynes, Robert B. Santulli, Kaycee M. Sink, Mia Yang, Akiva Mintz, Del D. Miller, Karen Ekstam Smith, Hristina Koleva, Ki Won Nam, Hyungsub Shim, Susan K. Schultz, Amanda Smith, Christi Leach, Balebail Ashok Raj, Kristin Fargher, Eric M. Reiman, Kewei Chen, Pierre N. Tariot, Anna Burke, Joel Hetelle, Kathryn DeMarco, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Edward Zamrini, Christine M. Belden, Sherye A. Sirrel, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Charles Bernick, Donna Munic, Zaven S. Khachaturian, Neil Buckholtz, John Hsiao, William Z. Potter, Howard Fillit, Franz Hefti, Carl Sadowsky, Teresa Villena, Ging‐Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, William Pavlosky,
Alzheimer's disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with AD and in an AD mouse model. It accumulates within amyloid deposits, physically ...
Nature Portfolio
David Becerra, Tong Wu, Sydney Jeffs, Harald C. Ott,
Lung regeneration is dependent on the availability of progenitor lung cells. Large numbers of self-renewing, patient-specific induced pluripotent stem cell-derived alveolar epithelial cells (iPSC-AECs) are needed to adequately recellularize whole-organ constructs. Prior methods to generate functional iPSC-AECs are not feasible for large-scale cell production. We present a novel protocol to produce iPSC-AECs, which is scalable for whole-organ regeneration. Differentiation of iPSCs was performed with ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2021 - Mary Ann Liebert, Inc. | Tissue Engineering Part C Methods
David Becerra, Sydney Jeffs, Gregory R. Wojtkiewicz, Harald C. Ott,
Abstract OBJECTIVES Emphysema affects millions of patients worldwide. Cell transplantation and tissue engineering are promising approaches for the regeneration of gas exchange tissue in vivo. A reproducible and resource-efficient animal model with relevant pathological and physiological features is critical to assess efficacy of novel therapies. Here, we share a method for rapid development of emphysema in an adaptive immune-deficient rat with <5% mortality, which is ideal for high-throughput ...
Tópico(s): Respiratory Support and Mechanisms
2020 - Oxford University Press | European Journal of Cardio-Thoracic Surgery
B. Becerra, Jeff Linderoth, H. Pesin, Adrian Tudorascu, R. Wassink,
Tópico(s): Nonlinear Partial Differential Equations
2025 - Elsevier BV | Journal of Mathematical Analysis and Applications
Tracy A. Becerra-Culqui, Lina S. Sy, Bradley K. Ackerson, Jeff Slezak, Yi Luo, Christine A. Fischetti, Yvonne U. Ohadike, Carlo Curina, Michele Pellegrini, Zendi Solano, Sara Y. Tartof, Hung Fu Tseng,
The quadrivalent meningococcal conjugate vaccine MenACWY-CRM is recommended for 2-23 month-old infants/toddlers at increased risk for meningococcal disease. This study adds to the current knowledge of MenACWY-CRM safety among this age group in a clinical care setting.Kaiser Permanente Southern California members aged 2-23 months who received MenACWY-CRM between July 2014 and June 2017 were included. Electronic health records were searched for emergency department (ED) and hospitalization encounters, ...
Tópico(s): Pneumonia and Respiratory Infections
2019 - Elsevier BV | Vaccine
Christoper A. Alarcon‐Ruiz, Zoila Romero-Albino, Percy Soto-Becerra, Jeff Huarcaya-Victoria, Fernando M. Runzer‐Colmenares, Elisa Romani-Huacani, David Villarreal‐Zegarra, Jorge L. Maguiña, Moisés Apolaya-Segura, María Sofía Cuba-Fuentes,
Background: The COVID-19 pandemic significantly impacted the mental and emotional health of the elderly, especially those from low to middle-income countries. However, COVID-19 vaccination may reduce this influence. Therefore, we aimed to estimate the effect of vaccination against COVID-19 on the emotional health of older adults. Methods: We selected a national, random, and stratified sample of non-hospitalized adults aged 60 to 79 years from Peru who intended to receive or had already received the COVID-19 ...
Tópico(s): COVID-19 epidemiological studies
2022 - Faculty of 1000 | F1000Research
David Becerra, Helena Linge, Sydney Jeffs, Steven A. Roberts, O Jane, Harald C. Ott,
Lung transplantation remains the only curative treatment for end-stage pulmonary disease. Lung ischemia-reperfusion injury (IRI) is a major contributor to primary allograft dysfunction and donor organ nonutilization. The alveolar macrophage is a key inflammatory mediator in IRI. Ex vivo lung perfusion (EVLP) has been investigated to rehabilitate lungs before transplant but has failed to provide significant improvements after IRI. We hypothesized that liquid ventilation (LV) could be utilized for ex ...
Tópico(s): Mechanical Circulatory Support Devices
2022 - Mary Ann Liebert, Inc. | Tissue Engineering Part A
David Becerra, Sydney Jeffs, Tong Wu, Harald C. Ott,
Purpose Induced pluripotent stem cell derived alveolar epithelial cells (iPSC-AECs) are a patient specific cell source for bio-engineering of human pulmonary epithelium. Disease modeling and therapeutic applications require cost effective and technically feasible differentiation and expansion protocols. Current culture protocols are labor and resource intensive and not scalable for large animal or human studies. We developed a scalable culture protocol switching from adherent hydrogel drops to suspension ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2021 - Elsevier BV | The Journal of Heart and Lung Transplantation
Delonia Cooley, Jeff Brice, Enrique Becerra, Sindy Chapa,
INTRODUCTIONMulti-ethnic U.S. Smarkets, or markets consisting of groups of individuals with distinct ethnic origins, culture, language, history, customs, religion, or features (Riggins 1992) located in the United States, present marketers with an advertising strategy conundrum. Should they invest in ethnic-specific or standardized advertisements? Since individuals have been shown to be more likely to self-define on characteristics, like ethnicity, that makes them distinctive relative to others (McGuire ...
Tópico(s): Consumer Market Behavior and Pricing
2015 - Allied Academies | Academy of Marketing Studies journal
Daniela Becerra, HM Linge, S.C. Jeffs, Scott J. Roberts, J. O, Harald C. Ott,
Results: Patient discharged on multi-agent regimen with plan to complete 6-month course of IV L-AmB, followed by lifelong oral isavuconazole and inhaled L-AmB.Subsequent TBBx without evidence of mucormycosis.Conclusion: Delays in diagnosis and treatment of mucormycosis is lifethreatening, especially in the native lung after single LTx.Patient likely failed oral isavuconazole monotherapy due to decreased blood supply to native lung after single LTx.Inhaled antifungals in conjunction with early surgical ...
Tópico(s): Cardiac Ischemia and Reperfusion
2021 - Elsevier BV | The Journal of Heart and Lung Transplantation
Mert R. Sabuncu, Tian Ge, Avram J. Holmes, Jordan W. Smoller, Randy L. Buckner, Bruce Fischl, Michael W. Weiner, Paul Aisen, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Zaven S. Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven M. Paul, Peter Davies, Howard Fillit, Franz Hefti, David M. Holtzman, Marek-Marsel Mesulam, William Z. Potter, Peter J. Snyder, Adam J. Schwartz, Robert C. Green, Tom Montine, Ronald Petersen, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian, Jennifer Mason, Iris Sim, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R. Jack, Matt A. Bernstein, Nick C. Fox, Paul Thompson, Norbert Schuff, Charles DeCarli, Bret Borowski, Jeff Gunter, Matthew L. Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, William J. Jagust, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, John C. Morris, Nigel J. Cairns, Erin Franklin, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Virginia Lee, Magdalena Korecka, Michal Figurski, Arthur W. Toga, Karen Crawford, Scott Neu, Andrew J. Saykin, Tatiana Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Michael W. Weiner, Lean Thal, Leon J. Thal, Neil Buckholtz, Michael W. Weiner, Peter J. Snyder, William Z. Potter, Steven M. Paul, Marilyn Albert, R.T. Frank, Zaven S. Khachaturian, John Hsiao, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne Lord, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva‐Meyer, Valory Pavlik, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau M. Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Erik D. Roberson, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo‐Morrell, Ranjan Duara, Maria T. Greig‐Custo, Warren Barker, Marilyn Albert, Chiadi Onyike, Daniel D’Agostino, Stephanie Kielb, Martin Sadowski, Mohammed O. Sheikh, Anaztasia Ulysse, Mrunalini Gaikwad, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Steven E. Arnold, Jason Karlawish, S. J. Wolk, Christopher Clark, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Steven G. Potkin, Adrian Preda, Dana Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana G. Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po H. Lu, George Bartzokis, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Curtis Caldwell, Ging‐Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek-Marsel Mesulam, Emily Rogalskı, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy E. Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Jerome A. Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, E. Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T‐Y Lee, Dr Rob Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven Potkin, Adrian Preda, Dana Nguyen, Pierre N. Tariot, Anna Burke, Ann Marie Milliken, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre,
Significance Neuroimaging has largely focused on two goals: mapping associations between neuroanatomical features and phenotypes and building individual-level prediction models. This paper presents a complementary analytic strategy called morphometricity that aims to measure the neuroanatomical signatures of different phenotypes. Inspired by prior work on heritability, we define morphometricity as the proportion of phenotypic variation that can be explained by brain morphology (e.g., as captured ...
National Academy of Sciences
Chenzhong Yin, Phoebe Imms, Mingxi Cheng, Anar Amgalan, Nahian F. Chowdhury, Roy J Massett, Nikhil N. Chaudhari, Xinghe Chen, Paul M. Thompson, Paul Bogdan, Andrei Irimia, Michael W. Weiner, Paul Aisen, Ronald Petersen, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Zaven S. Khachaturian, María C. Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Richard J. Perrin, Laurie Ryan, Nina Silverberg, Adam Fleisher, Eli Lilly, Michael W. Weiner, Diana Truran Sacrey, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormos, Robert C. Green, Tom Montine, Cat Conti, Ronald Petersen, Paul Aisen, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Brittany Sloan, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R. Jack, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Danielle Harvey, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, William J. Jagust, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, John C. Morris, Richard J. Perrin, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Magdalena Korecka, Michal Figurski, Arthur W. Toga, Karen Crawford, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana M. Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Michael W. Weiner, Leon J. Thal, Zaven S. Khachaturian, John K. Hsiao, Lisa Silbert, Betty Lind, Rachel Crissey, Jeffrey Kaye, Raina Carter, Sara Dolen, Joseph F. Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James B. Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villanueva-Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, John C. Morris, David Winkfield, Maria Carroll, Georgia Stobbs-Cucchi, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Daniel Marson, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi U. Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, Jamika Singleton-Garvin, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Salvador Borges‐Neto, Jason Karlawish, S. J. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Dung Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Ellen Woo, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow, Susan Vaitekunis, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Chris Heyn, Ging‐Yuek Robin Hsiung,
The gap between chronological age (CA) and biological brain age, as estimated from magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging deviate from their typical trajectories. MRI-derived brain age (BA) estimates are often obtained using deep learning models that may perform relatively poorly on new data or that lack neuroanatomic interpretability. This study introduces a convolutional neural network (CNN) to estimate BA after training on the MRIs of 4,681 cognitively ...
National Academy of Sciences
Diana I. Bocancea, Anna L. Svenningsson, Anna C. van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Michael W. Weiner, Paul Aisen, Ronald Petersen, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Zaven S. Khachaturian, Maria Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Laurie Ryan, Nina Silverberg, Adam Fleisher, Michael W. Weiner, Diana Truran Sacrey, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormo, Robert C. Green, Tom Montine, Cat Conti, Ronald Petersen, Paul Aisen, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R. Jack, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David T. Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Danielle Harvey, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawfor, Paul A. Yushkevich, Sandhitsu R. Das, William J. Jagust, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, John C. Morris, Richard J. Perrin, Nigel J. Cairns, Haley Bernhardt, Leslie M. Shaw, Michal Figurski, Arthur W. Toga, Karen Crawfor, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana Foroud, Kelly Nudelman, Kelley Faber, Michael W. Weiner, John Hsiao, Lisa Silbert, Jeffrey Kaye, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villanueva-Meyer, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Munir Chowdhury, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, John C. Morris, David Winkfield, Maria Carroll, Angela Oliver, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, John Brockington, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuel, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Salvador Borges‐Neto, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Nguyen, Kyle Womack, Dana Mathews, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Susan P. Good, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow, Susan Vaitekunis, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Chris Heyn, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, Andrew Kertesz, Dick Drost, Ian Grant, Brittanie Muse, Emily Rogalskı, Jordan Robso, M-Marsel Mesulam, Chuang‐Kuo Wu, Nancy E. Johnson, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Howard J. Rosen, Bruce L. Miller, David C. Perry, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Kelly McCann, Jessica Poe, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Jerome A. Yesavage, Joy L. Taylor, Steven Chao, Jaila Coleman, Jessica D. White, Barton Lane,
Abstract Mechanisms of resilience against tau pathology in individuals across the Alzheimer’s disease spectrum are insufficiently understood. Longitudinal data are necessary to reveal which factors relate to preserved cognition (i.e. cognitive resilience) and brain structure (i.e. brain resilience) despite abundant tau pathology, and to clarify whether these associations are cross-sectional or longitudinal. We used a longitudinal study design to investigate the role of several demographic, biological ...
Oxford University Press
Michael Robinson, Jeff Boissoneault, Landrew S. Sevel, Janelle E. Letzen, Roland Staud,
... has not yet been successfully performed.5Borsook D. Becerra L. Hargreaves R. Biomarkers for chronic pain and ... 2011; 11: 197-207PubMed Google Scholar, 6Borsook D. Becerra L. Hargreaves R. Biomarkers for chronic pain and ...
Tópico(s): Acupuncture Treatment Research Studies
2016 - Elsevier BV | Journal of Pain
... Open AccessTaking health into account in all policiesFrancisco Becerra-Posada (July, 2015)1 writes about the efforts ...
Tópico(s): Healthcare Systems and Reforms
2015 - Elsevier BV | The Lancet Global Health
Xiaopu Zhou, Yu Chen, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K.Y. Fu, Qihao Guo, Nancy Y. Ip, Andrew J. Saykin, Arthur W. Toga, Bret Borowski, Chad Ward, Charles DeCarli, Chester A. Mathis, Clifford R. Jack, Danielle Harvey, David M. Holtzman, David T. Jones, Devon Gessert, Eli Lilly, Eric M. Reiman, Erin Franklin, Franz Hefti, Greg Sorensen, Gustavo Jiménez, Howard Fillit, Jeff Gunter, Jennifer Salazar, John Hsiao, John C. Morris, John Q. Trojanowki, Karen Crawford Scott Neu, Kejal Kantarci, Kelley Faber, Kelly Harless, Kewei Chen, Kwangsik Nho, Laurel Beckett, Lean Thal, Leon J. Thal, Leslie M. Shaw, Lew Kuller, Li Shen, Lindsey Hergesheimer, Lisa Taylor‐Reinwald, Marek M. Mesulam, Magdalena Korecka, Marc Raichle, María C. Carrillo, Marilyn Albert, Matthew L. Senjem, Matt A. Bernstein, Michael Donohue, Michael W. Weiner, Michal Figurski, Neil Buckholtz, Nick C. Fox, Nigel J. Cairns, Norbert Schuff, Norm Foster, Paul Aisen, Paul M. Thompson, Peter Davies, Peter J. Snyder, Peter J. Snyder, Prashanthi Vemuri, Richard Frank, Robert A. Koeppe, Christopher Green, Ronald Petersen, Sarah Walter, Steven M. Paul, Steven Potkin, Sungeun Kim, Tatiana M. Foroud, Tom Montine, Virginia Lee, William J. Jagust, William Z. Potter, Yuliana Cabrera, Zaven S. Khachaturian, Adam Fleisher, Aimee Pierce, Akiva Mintz, Alan J. Lerner, Alexander Norbash, Allan I. Levey, Allyson Rosen, Amanda Smith, Anaztasia Ulysse, Andrew E. Budson, Andrew Kertesz, Angela Oliver, Ann Marie Hake, Anna Burke, Antero Sarrael, Anton P. Porsteinsson, Ashley Lamb, Athena Lee, Balebail Ashok Raj, Barton Lane, Beatriz Yáñez‐Rivera, Beau M. Ances, Benita Mudge, Betty Lind, Bojana Stefanovic, Bonnie S. Goldstein, Borna Bonakdarpour, Brandy R. Matthews, Brian R. Ott, Brigid Reynolds, Bruce L. Miller, Bryan M. Spann, Carl Sadowsky, Charles Bernick, Charles D. Smith, Chiadi U. Onyike, Chris Heyn, Chris Hosein, Christi Leach, Christine M. Belden, Christopher H. van Dyck, Christopher M. Clark, Chuang‐Kuo Wu, Colleen S. Albers, Connie Brand, Courtney Bodge, Curtis Tatsuoka, Cynthia M. Carlsson, Dana Mathews, Daniel D’Agostino, Daniel Silverman, Daniel Marson, David A. Wolk, David Bachman, David W. Clark, David Geldmacher, David Hart, David S. Knopman, David C. Perry, David Winkfield, Del D. Miller, Diana Kerwin, Dick Drost, Donna M. Simpson, Donna Munic, Douglas W. Scharre, Robert Bartha, Dzintra Celmins, Earl A. Zimmerman, Edmond Teng, Edward Coleman, Edward Zamrini, Effie Mitsis, Elizabeth Finger, Elizabeth Oates, Elizabeth Sosa, Ellen Woo, Emily Rogalskı, Evan Fletcher, Francine Parfitt, Gaby Thai, Gad A. Marshall, Gary Conrad, Geoffrey Tremont, George Bartzokis, Ging‐Yuek Robin Hsiung, Gloria Chiang, Godfrey D. Pearlson, Gregory A. Jicha, Helen Vanderswag, Hillel Grossman, Horacio Capote, Howard Bergman, Howard Chertkow, Howard Feldman, Howard J. Rosen, Hristina Koleva, Hyungsub Shim, Irina Rachinsky, Jacobo Mintzer, Jaimie Ziolkowski, James B. Brewer, James J. Lah, Jamika Singleton-Garvin, Janet S. Cellar, Jared R. Brosch, Jared Tinklenberg, Jason Karlawish, Javier Villanueva‐Meyer, Jeffrey Kaye, Jeffrey M. Burns, Jeffrey R. Petrella, Jerome A. Yesavage, Joanne Allard, Joanne Lord, Joel Hetelle, John Brockington, John C. Morris, John Olichney, John Rogers, Joseph F. Quinn, Joseph S. Kass, Joy L. Taylor, Judith L. Heidebrink, Karen Anderson, Karen Blank, Karen Ekstam Smith, Karen L. Bell, Kathleen Johnson, Kathleen Tingus, Kathryn DeMarco, Kaycee M. Sink, Keith A. Johnson, Kelly M. Makino, Kenneth Spicer, Ki Won Nam, Kim Martin, Kim Poki-Walker, Kris Johnson, Kristin Fargher, Kristine Lipowski, Kyle Womack, Laura A. Flashman, Lawrence S. Honig, Liana G. Apostolova, Liberty Teodoro, Lisa Silbert, Lisa Ravdin, Lon S. Schneider, Lori A. Daiello, M. Saleem Ismail, Marc Seltzer, Marek-Marsel Mesulam, Maria Carroll, Maria Kataki, Maria T. Greig‐Custo, Marissa Natelson Love, Mark A. Mintun, Martin R. Farlow, Martin Sadowski, Mary L. Creech, Mary L. Hynes, Mary Quiceno, MaryAnn Oakley, Mauricio Becerra, Megan Witbracht, Melanie Keltz, Melissa Lamar, Mia Yang, Michael Borrie, Michael Lin, Michele Assaly, Michelle Rainka, Mimi Dang, Mohammed O. Sheikh, Mrunalini Gaikwad, Munir Chowdhury, Nadira Trncic, Nancy Johnson, Nancy Kowalksi, Nathaniel Pacini, Neil W. Kowall, Neill R. Graff‐Radford, Norman Relkin, Ntekim E. Oyonumo, Nunzio Pomara, Olga James, Olu Ogunlana, Oscar L. López, Owen Carmichael, P. Murali Doraiswamy, Parianne Fatica, Patricia Lynn Johnson, Patricia Samuels, Paul Malloy, Paula Ogrocki, Pauline Maillard, Peter Hardy, Pierre N. Tariot, Po H. Lu, Pradeep Varma, Rachelle S. Doody, Raina Carter, Raj C. Shah, Randall Griffith, Randy Yeh, Ranjan Duara, Rawan Tarawneh, Raymond Scott Turner, Raymundo Hernando, Reisa A. Sperling, Richard E. Carson,
Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel variant rs73052335, P = 1.44 × 10 −14 ), two common variants, GCH1 (rs72713460, P = 4.36 × 10 −5 ) and KCNJ15 (rs928771, P = 3.60 × 10 −6 ), were identified and further verified for their possible risk effects for AD in three small non-Asian AD cohorts. Genotype–phenotype analysis showed that KCNJ15 ...
National Academy of Sciences
Xue‐Ning Shen, Yu‐Yuan Huang, Shi-Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin‐Tai Yu, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, María C. Carrillo, William C. Potter, Lisa L. Barnes, Marie Bernard, Hector M. González, Carole Ho, John K. Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Richard J. Perrin, Laurie Ryan, Nina Silverberg, Adam Fleisher, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormos, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Brittany Sloan, Danielle Harvey, Bret Borowski, Chad Ward, Christopher G. Schwarz, David Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert C. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, Richard J. Perrin, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Leon J. Thal, Zaven S. Khachaturian, John K. Hsiao, Lisa Silbert, Betty Lind, Rachel Crissey, Jeffrey Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villanueva‐Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, David Winkfield, Maria Carroll, Georgia Stobbs-Cucchi, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Daniel Marson, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, Jamika Singleton-Garvin, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Salvador Borges‐Neto, Jason H. Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Ellen Woo, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Susan P. Good, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow, Susan Vaitekunis, Chris Hosein, Sandra Black, Bojana Stefanovic, Chris Heyn, Ging‐Yuek Robin Hsiung, Ellen Kim, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, Andrew Kertesz, Dick Drost, John Rogers, Ian Grant, Brittanie Muse, Emily Rogalskı, Jordan Robson, M.‐Marsel Mesulam, Diana Kerwin, Chuang-Kuo Wu, Nancy Johnson, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Howard J. Rosen, Bruce L. Miller, David C. Perry, Raymond Scott Turner, Kathleen Johnson,
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker for Alzheimer’s pathology in the brain. A total of 1189 participants with plasma p-tau181 and PET data of amyloid, tau or FDG PET were included from ADNI. Cross-sectional relationships of plasma p-tau181 with PET biomarkers were tested. Longitudinally, we further investigated ...
Springer Nature
Shi-Dong Chen, Jiaying Lu, Hong‐Qi Li, Yuxiang Yang, Jiehui Jiang, Mei Cui, Chuantao Zuo, Lan Tan, Qiang Dong, Jin‐Tai Yu, Michael W. Weiner, Paul Aisen, Ronald C. Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, María C. Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Richard J. Perrin, Laurie Ryan, Nina Silverberg, Adam Fleisher, Diana Truran Sacrey, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormos, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Brittany Sloan, Danielle Harvey, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David T. Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana M. Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Leon J. Thal, Zaven S. Khachaturian, John Hsiao, Lisa Silbert, Betty Lind, Rachel Crissey, Jeffrey Kaye, Raina Carter, Sara Dolen, Joseph F. Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villanueva‐Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, David Winkfield, Maria Carroll, Georgia Stobbs-Cucchi, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Daniel Marson, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi U. Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, Jamika Singleton-Garvin, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Salvador Borges‐Neto, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Ellen Woo, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Susan P. Good, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow, Susan Vaitekunis, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Chris Heyn, Ging‐Yuek Robin Hsiung, Ellen Kim, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, Andrew Kertesz, Dick Drost, John Rogers, Ian Grant, Brittanie Muse, Emily Rogalskı, Jordan Robson, M.‐Marsel Mesulam, Diana Kerwin, Chuang‐Kuo Wu, Nancy Johnson, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Nunzio Pomara,
Abstract A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo tau progression using biomarker, we constructed a refined topographic 18 F-AV-1451 tau PET staging scheme with longitudinal clinical validation. Seven hundred and thirty-four participants with baseline 18 F-AV-1451 ...
Springer Nature
Yi‐Ting Wang, Joseph Therriault, Stijn Servaes, Cécile Tissot, Nesrine Rahmouni, Arthur C. Macedo, Jaime Fernández Arias, Sulantha Mathotaarachchi, Andréa Lessa Benedet, Jenna Stevenson, Nicholas J. Ashton, Firoza Z Lussier, Tharick A. Pascoal, Henrik Zetterberg, Maria Natasha Rajah, Kaj Blennow, Serge Gauthier, Pedro Rosa‐Neto, Michael W Weiner, Paul Aisen, Michael W Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Zaven S. Khachaturian, Maria Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, John Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Richard J. Perrin, Laurie Ryan, Nina Silverberg, Adam Fleisher, Michael W Weiner, Diana Truran Sacrey, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormos, Robert C. Green, Tom Montine, Cat Conti, Ronald Petersen, Paul Aisen, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Brittany Sloan, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R. Jack, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Danielle Harvey, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, William J. Jagust, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, John C. Morris, Richard J. Perrin, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Magdalena Korecka, Michal Figurski, Arthur W Toga, Scott Neu, Andrew J. Saykin, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Michael W Weiner, Leon J. Thal, Zaven S. Khachaturian, John Hsiao, Lisa Silbert, Betty Lind, Rachel Crissey, Jeffrey Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villanueva-Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, John C. Morris, David Winkfield, Maria Carroll, Georgia Stobbs-Cucchi, Angela Oliver, Mark A. Mintun, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Daniel Marson, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, Jamika Singleton-Garvin, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Salvador Borges‐Neto, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, H S Daniel Silverman, Sarah Kremen, Liana G. Apostolova, Kathleen Tingus, Po H. Lu, George Bartzokis, Ellen Woo, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Adam P. Mecca, Susan P. Good, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow, Susan Vaitekunis, Chris Hosein, Sandra E. Black,
Abstract Females are disproportionately affected by dementia due to Alzheimer's disease. Despite a similar amyloid-β (Aβ) load, a higher load of neurofibrillary tangles (NFTs) is seen in females than males. Previous literature has proposed that Aβ and phosphorylated-tau (p-tau) synergism accelerates tau tangle formation, yet the effect of biological sex in this process has been overlooked. In this observational study, we examined longitudinal neuroimaging data from the TRIAD and ADNI cohorts from Canada ...
Oxford University Press
Xiuming Zhang, Elizabeth C. Mormino, Nanbo Sun, Reisa A. Sperling, Mert R. Sabuncu, B.T. Thomas Yeo, Michael W. Weiner, Paul Aisen, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Zaven S. Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven M. Paul, Peter Davies, Howard Fillit, Franz Hefti, David M. Holtzman, M. Marcel Mesulam, William Z. Potter, Peter J. Snyder, Adam J. Schwartz, Robert C. Green, Tom Montine, Ronald Petersen, Paul Aisen, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Archana B. Balasubramanian, Jennifer Mason, Iris Sim, Laurel Beckett, Danielle Harvey, Michael Donohue, Clifford R. Jack, Matt A. Bernstein, Nick C. Fox, Paul Thompson, Norbert Schuff, Charles DeCarli, Davis Bret Borowski, Jeff Gunter, Matthew L. Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, William J. Jagust, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, John C. Morris, Nigel J. Cairns, Erin Franklin, Lisa Taylor‐Reinwald, Leslie M. Shaw, John Q. Trojanowki, Virginia Lee, Magdalena Korecka, Michal Figurski, Arthur W. Toga, Karen Crawford, Scott Neu, Andrew J. Saykin, Tatiana Foroud, Steven Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Michael W. Weiner, Lean Thal, Zaven S. Khachaturian, Leon J. Thal, Neil Buckholtz, Michael W. Weiner, Peter J. Snyder, William Z. Potter, Steven M. Paul, Marilyn Albert, R.T. Frank, Zaven S. Khachaturian, John Hsiao, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne Lord, Ronald Petersen, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva‐Meyer, Valory Pavlik, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau M. Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, David Geldmacher, Marissa Natelson Love, Randall Griffith, David A. Clark, John Brockington, Erik D. Roberson, Hillel Grossman, Effie Mitsis, Raj C. Shah, Leyla deToledo‐Morrell, Ranjan Duara, Maria T. Greig‐Custo, Warren Barker, Marilyn Albert, Chiadi Onyike, Daniel D’Agostino, Stephanie Kielb, Martin Sadowski, Mohammed O. Sheikh, Anaztasia Ulysse, Mrunalini Gaikwad, P. Murali Doraiswamy, Jeffrey R. Petrella, Salvador Borges‐Neto, Terence Z. Wong, Edward Coleman, Steven E. Arnold, Jason H. Karlawish, David A. Wolk, Christopher Clark, Charles D. Smith, Gregory A. Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Steven Potkin, Adrian Preda, Dana Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Liana G. Apostolova, Kathleen Tingus, Ellen Woo, Daniel Silverman, Po H. Lu, George Bartzokis, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Pradeep Varma, Howard Chertkow, Howard Bergman, Chris Hosein, Sandra E. Black, Bojana Stefanovic, Curtis Caldwell, Ging‐Yuek Robin Hsiung, Benita Mudge, Vesna Sossi, Howard Feldman, Michele Assaly, Elizabeth Finger, Stephen Pasternack, Irina Rachisky, Dick Trost, Andrew Kertesz, Charles Bernick, Donna Munic, Marek-Marsel Mesulam, Emily Rogalskı, Kristine Lipowski, Sandra Weıntraub, Borna Bonakdarpour, Diana Kerwin, Chuang‐Kuo Wu, Nancy E. Johnson, Carl Sadowsky, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Jerome A. Yesavage, Joy L. Taylor, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil W. Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Thomas O. Obisesan, Saba Wolday, Joanne Allard, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Parianne Fatica, E. Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Owen Carmichael, Smita Kittur, Michael Borrie, T‐Y Lee, Robert Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Steven Potkin, Adrian Preda, Dana Nguyen, Pierre N. Tariot, Anna Burke, Ann Marie Milliken, Nadira Trncic, Adam Fleisher, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka,
Significance Alzheimer’s disease (AD) affects 10% of the elderly population. The disease remains poorly understood with no cure. The main symptom is memory loss, but other symptoms might include impaired executive function (ability to plan and accomplish goals; e.g., grocery shopping). The severity of behavioral symptoms and brain atrophy (gray matter loss) can vary widely across patients. This variability complicates diagnosis, treatment, and prevention. A mathematical model reveals distinct brain ...
National Academy of Sciences
Zahra Shirzadi, Stephanie A. Schultz, Wai‐Ying Wendy Yau, Nelly Joseph‐Mathurin, Colleen Fitzpatrick, Raina Levin, Kejal Kantarci, Gregory M. Preboske, Clifford R. Jack, Martin R. Farlow, Jason Hassenstab, Mathias Jucker, John C. Morris, Chengjie Xiong, Celeste M. Karch, Allan I. Levey, Brian A. Gordon, Peter R. Schofield, Stephen Salloway, Richard J. Perrin, Eric McDade, Johannes Levin, Carlos Cruchaga, Ricardo Allegri, Nick C. Fox, Alison Goate, Gregory S. Day, Robert A. Koeppe, Helena C. Chui, Sarah Berman, Hiroshi Mori, Raquel Sánchez‐Valle, Jae‐Hong Lee, Pedro Rosa‐Neto, Myuri Ruthirakuhan, Che‐Yuan Wu, Walter Swardfager, Tammie L.S. Benzinger, Hamid R. Sohrabi, Ralph N. Martins, Randall J. Bateman, Keith A. Johnson, Reisa A. Sperling, Steven M. Greenberg, Aaron P. Schultz, Jasmeer P. Chhatwal, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Zaven S. Khachaturian, Maria Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Laurie Ryan, Nina Silverberg, Adam Fleisher, Diana Truran Sacrey, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Miriam T. Ashford, Derek Flenniken, Adrienne Kormos, Tom Montine, Michael S. Rafii, Rema Raman, Gustavo Jiménez, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Brittany Sloan, Danielle Harvey, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David T. Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Prashanthi Vemuri, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul M. Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Duygu Tosun, Stephanie Rossi Chen, Mark Choe, Karen Crawford, Paul A. Yushkevich, Sandhitsu R. Das, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chester A. Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Magdalena Korecka, Michael Figurski, Scott Neu, Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Li Shen, Tatiana M. Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Leon J. Thal, Lisa Silbert, Betty Lind, Rachel Crissey, Jeffrey Kaye, Raina Carter, Sara Dolen, Joseph F. Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne Lord, Sara S. Mason, Colleen S. Albers, David S. Knopman, Kris Johnson, Javier Villaneuva-Meyer, Valory Pavlik, Nathaniel Pacini, Ashley Lamb, Joseph S. Kass, Rachelle S. Doody, Victoria Shibley, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, David Winkfield, Maria Carroll, Georgia Stobbs-Cucchi, Angela Oliver, Mary L. Creech, Mark A. Mintun, Stacy Schneider, David Geldmacher, Marissa Natelson Love, Randall Griffith, David Clark, John Brockington, Daniel Marson, Hillel Grossman, Martin Goldstein, Jonathan Greenberg, Effie Mitsis, Raj C. Shah, Melissa Lamar, Patricia Samuels, Ranjan Duara, Maria T. Greig‐Custo, Rosemarie Rodriguez, Marilyn Albert, Chiadi Onyike, Leonie Farrington, Scott Rudow, Rottislav Brichko, Stephanie Kielb, Amanda Smith, Balebail Ashok Raj, Kristin Fargher, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, Arline Faustin, Julia Rao, Karen M. Castro, Anaztasia Ulysse, Shannon Chen, Mohammed O. Sheikh, Jamika Singleton-Garvin, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Terence Z. Wong, Salvador Borges‐Neto, Jason Karlawish, David A. Wolk, Sanjeev Vaishnavi, Christopher M. Clark, Steven E. Arnold, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Flavius D. Raslau, Oscar L. López, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Kim Martin, Nancy Kowalski, Melanie Keltz, Bonnie S. Goldstein, Kelly M. Makino, M. Saleem Ismail, Connie Brand, Gaby Thai, Aimee Pierce, Beatriz Yáñez‐Rivera, Elizabeth Sosa, Megan Witbracht, Brendan Kelley, Trung Dung Nguyen, Kyle Womack, Dana Mathews, Mary Quiceno, Allan I. Levey, James J. Lah, Ihab Hajjar, Janet S. Cellar, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Kathleen Tingus, Po H. Lu, George Bartzokis, Ellen Woo, Edmond Teng, Neill R. Graff‐Radford, Francine Parfitt, Kim Poki-Walker, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Jared R. Brosch, Scott Herring, Christopher H. van Dyck, Adam P. Mecca, Susan P. Good, Martha G. MacAvoy, Richard E. Carson, Pradeep Varma, Howard Chertkow,
Importance Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. Objective To estimate the associations of neurodegeneration and parenchymal and vessel amyloidosis with WMH accumulation and investigate ...
American Medical Association
Hao Zhou, Vikas Singh, Sterling C. Johnson, Grace Wahba, Adam Fleisher, Adrian Preda, Aimee Pierce, Akiva Mintz, Alan J. Lerner, Alexander Norbash, Allan I. Levey, Allyson Rosen, Amanda Smith, Anaztasia Ulysse, Andrew E. Budson, Andrew J. Saykin, Andrew Kertesz, Angela Oliver, Ann Marie Hake, Anna Burke, Ansgar J. Furst, Antero Sarrael, Anton P. Porsteinsson, Arthur W. Toga, Ashley Lamb, Athena Lee, Balebail Ashok Raj, Barton Lane, Beatriz Yáñez‐Rivera, Beau M. Ances, Benita Mudge, Betty Lind, Bojana Stefanovic, Bonnie S. Goldstein, Bonnie S. Goldstein, Borna Bonakdarpour, Brandy R. Matthews, Bret Borowski, Brian R. Ott, Brigid Reynolds, Bruce L. Miller, Bryan M. Spann, Carl Sadowsky, Chad Ward, Charles Bernick, Charles D. Smith, Chester A. Mathis, Chiadi Onyike, Chris Heyn, Chris Hosein, Christi Leach, Christine M. Belden, Christopher H. van Dyck, Christopher Clark, Chuang‐Kuo Wu, Clifford R. Jack, Colleen S. Albers, Connie Brand, Courtney Bodge, Craig Nelson, Curtis Tatsuoka, Cynthia M. Carlsson, Dana Mathews, Dana Nguyen, Daniel Catalinotto, Daniel D’Agostino, Daniel Silverman, Daniel Marson, Daniel Varon, Danielle Harvey, Dariella Fernandez, David A. Wolk, David Bachman, David Bickford, David Clark, David Geldmacher, David M. Hart, David M. Holtzman, David T. Jones, David S. Knopman, David C. Perry, David Winkfield, Debra Fleischman, Del D. Miller, Denise A. Reyes, Devon Gessert, Devon Gessert, Diana Kerwin, Dick Drost, Dino Massoglia, Donna M. Simpson, Donna Munic, Douglas W. Scharre, Dzintra Celmins, Earl A. Zimmerman, Edmond Teng, Edward Coleman, Edward Zamrini, Effie Mitsis, Elaine R. Peskind, Eli Lilly, Elise Ong, Elizabeth Finger, Elizabeth Oates, Elizabeth Shaffer, Elizabeth Sosa, Ellen Woo, Emily Rogalskı, Eric C. Petrie, Eric M. Reiman, Erin Drake, Erin Franklin, Erin Householder, E. Fletcher, Francine Parfitt, Franz Hefti, Gaby Thai, Gad A. Marshall, Gad A. Marshall, Gail Li, Gary Conrad, Geoffrey Tremont, George Bartzokis, Ging‐Yuek Robin Hsiung, Gloria Chiang, Godfrey D. Pearlson, Gregory A. Jicha, Greg Sorensen, Gustavo Jiménez, Helen Vanderswag, Hillel Grossman, Horacio Capote, Howard Bergman, Howard Chertkow, Howard Feldman, Howard Fillit, Howard J. Rosen, Howard Rosen, Hristina Koleva, Hyungsub Shim, Irina Rachinsky, J. Jay Fruehling, Jacobo Mintzer, Jacqueline Hayes, Jaimie Ziolkowski, James Brewer, James J. Lah, Jamika Singleton-Garvin, Janet S. Cellar, Jared R. Brosch, Jared Tinklenberg, Jason H. Karlawish, Javier Villanueva‐Meyer, Jeff Gunter, Jeffrey Kaye, Jeffrey M. Burns, Jeffrey R. Petrella, Jennifer Salazar, Jerome A. Yesavage, Jerome A. Yesavage, Joanne Allard, Joanne Lord, Joel Hetelle, John Brockington, John C. Morris, John Hsiao, John C. Morris, John Olichney, John Q. Trojanowki, John Rogers, Jordan Grafman, Joseph Quinn, Joseph S. Kass, Joy L. Taylor, Judith L. Heidebrink, Karen Anderson, Karen Blank, Karen Crawford, Karen Ekstam Smith, Karen L. Bell, Karl E. Friedl, Kathleen Johnson, Kathleen Tingus, Kathryn DeMarco, Kaycee M. Sink, Keith A. Johnson, Kejal Kantarci, Kelley Faber, Kelley Faber, Kelly E. Behan, Kelly Harless, Kelly M. Makino, Kelly Nudelman, Kelly Scherer, Kenneth Spicer, Kewei Chen, Ki Won Nam, Kim Martin, Kim Poki-Walker, Kimberly S. Martin, Konstantinos Arfanakis, Kris Johnson, Kristin Fargher, Kristine Lipowski, Kwangsik Nho, Kyle Womack, Laura A. Flashman, Laurel Beckett, Lawrence S. Honig, Lean Thal, Leon J. Thal, Leslie M. Shaw, Lew Kuller, Li Shen, Liana G. Apostolova, Liberty Teodoro, Lindsey Hergesheimen, Lindsey Hergesheimer, Lisa Silbert, Lisa Ravdin, Lisa Taylor‐Reinwald, Lon S. Schneider, Lori A. Daiello, Marek-Marsel Mesulam, M. Saleem Ismail, Magdalena Korecka, Marc Raichle, Marc Seltzer, Marek-Marsel Mesulam, María C. Carrillo, Maria Carroll, Maria Kataki, Maria T. Greig, Maria T. Greig‐Custo, Marilyn Albert, Marissa Natelson Love, Mark A. Mintun, Martin R. Farlow, Martin Sadowski, Marwan N. Sabbagh, Mary L. Creech, Mary L. Hynes, Mary Quiceno, MaryAnn Oakley, Matthew L. Senjem, Matt A. Bernstein, Mauricio Becerra, Megan Witbracht, Melanie Keltz, Melissa Lamar, Meryl A. Butters, Mia Yang, Michael Borrie, Michael Donohue, Michael Z. Lin, Michael W. Weiner, Michael W. Weiner, Michal Figurski, Michele Assaly, Michelle Rainka, Michelle Zmuda, Mike Donohue, Mimi Dang, Mohammed O. Sheikh, Mrunalini Gaikwad, Munir Chowdhury, Nadira Trncic, Nancy Johnson, Nancy Kowalksi, Nathaniel Pacini, Neil Buckholtz, Neil W. Kowall, Neill R. Graff‐Radford, Nick C. Fox, Nigel J. Cairns, Norbert Schuff, Norm Foster, Norman Relkin, Ntekim E. Oyonumo, Nunzio Pomara, Olga Brawman‐Mintzer, Olga James, Olu Ogunlana, Oscar L. Lopez, Owen Carmichael, P. Murali Doraiswamy, Parianne Fatica, Patricia Lynn Johnson, Patricia Samuels, Paul Aisen, Paul Malloy, Paul M. Thompson, Paula Ogrocki, Pauline Maillard, Peter Davies, P. Hardy,
When sample sizes are small, the ability to identify weak (but scientifically interesting) associations between a set of predictors and a response may be enhanced by pooling existing datasets. However, variations in acquisition methods and the distribution of participants or observations between datasets, especially due to the distributional shifts in some predictors, may obfuscate real effects when datasets are combined. We present a rigorous statistical treatment of this problem and identify conditions ...
National Academy of Sciences
Lisa Holper, Andrea M. Gross, Felix Scholkmann, B. Kim Humphreys, Michael L. Meier, Ursula Wolf, Martin Wolf, Sabina Hotz‐Boendermaker,
... nociception and painKe Peng, Sarah C. Steele, Lino Becerra and David Borsook1 Feb 2018 | Progress in Neurobiology, ... cerebral hemodynamics using near-infrared spectroscopySarah A. Vinette, Jeff F. Dunn, Edward Slone and Paolo Federico26 May ...
Tópico(s): Musculoskeletal pain and rehabilitation
2014 - Imperial College Press | Journal of Integrative Neuroscience
Frank G. Shellock, Terry O. Woods, John V. Crues,
... epilepsyJohn M.Stern, Norman M.Spivak, Sergio A.Becerra, Taylor P.Kuhn, Alexander S.Korb, DavidKronemyer, NégarKhanlou, ...
Tópico(s): Genetic Neurodegenerative Diseases
2009 - Radiological Society of North America | Radiology
William T. Hu, Tuğba Öztürk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, Zaven Kachaturian, Maria Carrillo, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John Hsiao, Eliezer Masliah, Donna Masterman, Ozioma C. Okonkwo, Laurie Ryan, Nina Silverberg, Adam Fleisher, Tom Montine, Jeffrey Kaye, Lisa Silbert, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, James Brewer, Judith L. Heidebrink, David S. Knopman, Javier Villanueva‐Meyer, Rachelle S. Doody, Joseph S. Kass, Yaakov Stern, Lawrence S. Honig, Akiva Mintz, Beau M. Ances, Mark A. Mintun, David Geldmacher, Marissa Natelson Love, Hillel Grossman, Martin Goldstein, Raj C. Shah, Melissa Lamar, Ranjan Duara, Maria T. Greig‐Custo, Marilyn Albert, Chiadi U. Onyike, Amanda Smith, Martin Sadowski, Thomas Wısnıewskı, Melanie Shulman, P. Murali Doraiswamy, Jeffrey R. Petrella, Olga James, Jason Karlawish, David A. Wolk, Charles D. Smith, Gregory A. Jicha, Riham El Khouli, Oscar L. López, Anton P. Porsteinsson, Gaby Thai, Aimee Pierce, Brendan Kelley, Trung Nguyen, Kyle Womack, Allan I. Levey, James J. Lah, Jeffrey M. Burns, Russell H. Swerdlow, William M. Brooks, Daniel Silverman, Sarah Kremen, Neill R. Graff‐Radford, Martin R. Farlow, Christopher H. van Dyck, Adam P. Mecca, Howard Chertkow, Susan Vaitekunis, Sandra E. Black, Bojana Stefanovic, Chris Heyn, Ging‐Yuek Robin Hsiung, Vesna Sossi, Elizabeth Finger, Stephen Pasternak, Irina Rachinsky, Ian Grant, Emily Rogalskı, M.‐Marsel Mesulam, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Howard J. Rosen, Bruce L. Miller, David C. Perry, Raymond Scott Turner, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Jerome A. Yesavage, Joy L. Taylor, Steven Chao, Christine M. Belden, Alireza Atri, Bryan M. Spann, Ronald Killiany, Robert A. Stern, Jesse Mez, Thomas O. Obisesan, Oyonumo Ntekim, Alan J. Lerner, Paula Ogrocki, Curtis Tatsuoka, Evan Fletcher, Pauline Maillard, John Olichney, Charles DeCarli, Vernice Bates, Horacio Capote, Michael Borrie, T.-Y. Lee, Robert Bartha, Sterling C. Johnson, Sanjay Asthana, Cynthia M. Carlsson, Allison Perrin, Douglas W. Scharre, Maria Kataki, Rawan Tarawneh, David Hart, Earl A. Zimmerman, Dzintra Celmins, Del D. Miller, Hristina Koleva, Hyungsub Shim, Jeff D. Williamson, Suzanne Craft, Jo Cleveland, Brian R. Ott, Jonathan Drake, Geoffrey Tremont, Marwan N. Sabbagh, Aaron Ritter, Jacobo Mintzer, Joseph C. Masdeu, Jiong Shi, Paul Newhouse, Steven Potkin, Stephen Salloway, Paul Malloy, Stephen Correia, Smita Kittur, Godfrey D. Pearlson, Karen Blank, Laura A. Flashman, Marc Seltzer, Athena Lee, Norman Relkin, Gloria Chiang,
Abstract Neuroinflammation is associated with Alzheimer’s disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer’s Disease Neuro-imaging Initiative as well participants ...
Tópico(s): Dementia and Cognitive Impairment Research
2021 - Nature Portfolio | Nature Communications
Jeffrey S. Brown, Lisa Bastarache, Mark G. Weiner,
... Wiltse; Ramkiran Gouripeddi; Julio Facelli; Robert Clark; Benjamin Becerra; Yao Yan; Jimmy Phuong; Yooree Chae; Rena C. ...
Tópico(s): Artificial Intelligence in Healthcare
2021 - American Medical Association | JAMA Network Open