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Artigo Revisado por pares

Omar A. Minai, Basma Ricaurte, Roop Kaw, Jeff Hammel, Mary Mansour, Kevin McCarthy, Joseph A. Golish, James K. Stoller,

The correlates and consequences of pulmonary hypertension (PH) associated with obstructive sleep apnea (OSA) are poorly understood. Patients undergoing pulmonary artery catheterization within 6 months of an overnight polysomnography showing OSA were included in the present analysis. A total of 83 patients with complete data were analyzed (no PH, n = 25 [30%]; PH, 58 [70%]; of these, 18 had a pulmonary capillary wedge pressure of <15 mm Hg). No significant differences were observed between the PH and no ...

Tópico(s): Cardiovascular Function and Risk Factors

2009 - Elsevier BV | The American Journal of Cardiology

Artigo Revisado por pares

Herbert Eradat, Steven Coutré, Jacqueline C. Barrientos, Kanti Roop, Charles M. Farber, Peter Hillmen, Jeff P. Sharman, Paolo Ghia, Bertrand Coiffier, Jan Walewski, Zwi Berneman, Susan O’Brien, Jennifer R. Brown, Sissy Peterman, Roger Dansey, Thomas M. Jahn, Paula Cramer, Michael Hallek,

TPS7133 Background: PI3K-delta is critical for the activation, proliferation and survival of B cells and plays a role in homing and retention of B cells in lymphoid tissues. PI3Kδ signaling is hyperactive in many B-cell malignancies. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that reduces proliferation, enhances apoptosis, and alters trafficking of malignant B cells in lymphoid tissues (Lannutti, 2011). Phase 1 trials demonstrated that idelalisib is highly active in heavily ...

Tópico(s): Immunodeficiency and Autoimmune Disorders

2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology

Artigo Revisado por pares

Jacqueline C. Barrientos, Richard R. Furman, John P. Leonard, Ian W. Flinn, Kanti Roop, Sven de Vos, Marshall T. Schreeder, Nina D. Wagner‐Johnston, Jeff P. Sharman, Thomas E. Boyd, Nathan Fowler, Leanne Holes, David M. Johnson, Daniel Li, Roger Dansey, Thomas M. Jahn, Steven Coutré,

7017 Background: PI3K-delta signaling is critical for proliferation, survival, homing and tissue retention of malignant B cells. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown considerable monotherapy activity in pts with heavily pretreated CLL. Methods: This phase I study evaluated idelalisib continuously given at 150 mg BID in combination with rituximab (R, 375 mg/m 2 every wk x 8), bendamustine (B, 70 or 90 mg/m 2 x 2, every 4 wks x 6) or BR (every 4 wks x 6) for ...

Tópico(s): Monoclonal and Polyclonal Antibodies Research

2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology

Artigo Revisado por pares

Jeff Borggaard, Traian Iliescu, John Paul Roop,

In this paper, we present a rigorous numerical analysis for a bounded artificial viscosity model ($\tau=\mu\delta^\sigma a(\delta\|\nabla^s\bm{u}\|_F)\nabla^s\bm{u})$ for the numerical simulation of turbulent flows. In practice, the commonly used Smagorinsky model ($\tau=(c_s\delta)^2\|\nabla^s\bm{u}\|_F\,\nabla^s\bm{u}$) is overly dissipative and yields unphysical results. To date, several methods for "clipping" the Smagorinsky viscosity have proven useful in improving the physical characteristics of ...

Tópico(s): Computational Fluid Dynamics and Aerodynamics

2009 - Society for Industrial and Applied Mathematics | SIAM Journal on Numerical Analysis

Artigo Revisado por pares

Jeff Borggaard, Traian Iliescu, John Paul Roop,

Abstract The r ‐Laplacian has played an important role in the development of computationally efficient models for applications, such as numerical simulation of turbulent flows. In this article, we examine two‐level finite element approximation schemes applied to the Navier‐Stokes equations with r ‐Laplacian subgridscale viscosity, where r is the order of the power‐law artificial viscosity term. In the two‐level algorithm, the solution to the fully nonlinear coarse mesh problem is utilized in a single‐ ...

Tópico(s): Differential Equations and Numerical Methods

2011 - Wiley | Numerical Methods for Partial Differential Equations

Artigo Revisado por pares

Jeff Borggaard, Traian Iliescu, Hyesuk Lee, John Paul Roop, Hyunjin Son,

A two-level method for discretizing the Smagorinsky model for the numerical simulation of turbulent flows is proposed and analyzed. In the two-level algorithm, the solution to the fully nonlinear coarse mesh problem is utilized in a single-step linear fine mesh problem. When modeling parameters are chosen appropriately, the error in the two-level algorithm is comparable to the error in solving the fully nonlinear problem on the fine mesh. We demonstrate numerically that, for an appropriate choice ...

Tópico(s): Meteorological Phenomena and Simulations

2008 - Society for Industrial and Applied Mathematics | Multiscale Modeling and Simulation

Artigo Acesso aberto Revisado por pares

Amy Hai Yan Chan, Braden Te Ao, Christina Baggott, Alana Cavadino, Amber A. Eikholt, Matire Harwood, Joanna Hikaka, Dianna Gibbs, Mariana Hudson, Farhaan Mirza, M. Asif Naeem, Ruth Semprini, Catherina L. Chang, Kevin C. H. Tsang, Syed Ahmar Shah, Aron Jeremiah, Binu Abeysinghe, Rajshri Roy, Clare Wall, Lisa G. Wood, Stuart R Dalziel, Hilary Pinnock, Job F. M. van Boven, Partha S. Roop, Jeff Harrison,

Introduction Asthma attacks are a leading cause of morbidity and mortality but are preventable in most if detected and treated promptly. However, the changes that occur physiologically and behaviourally in the days and weeks preceding an attack are not always recognised, highlighting a potential role for technology. The aim of this study ‘DIGIPREDICT’ is to identify early digital markers of asthma attacks using sensors embedded in smart devices including watches and inhalers, and leverage health ...

Tópico(s): Mobile Health and mHealth Applications

2024 - BMJ | BMJ Open Respiratory Research

Artigo Revisado por pares

Jeff Borggaard, Traian Iliescu, John Paul Roop,

For the numerical approximation of fluid flow phenomena, it is often highly desirable to decouple the equations defining conservation of momentum and conservation of mass by using a penalty function method. The current penalty function methods for power-law Stokes fluids converge at a sublinear rate with respect to the penalty parameter. In this article, we show theoretically and numerically that a linear penalty function approximation to a power-law Stokes problem yields a higher-order accuracy ...

Tópico(s): Numerical methods in engineering

2008 - Elsevier BV | Journal of Computational and Applied Mathematics

Artigo Revisado por pares

Jacqueline C. Barrientos, Steven Coutré, Sven de Vos, Ian W. Flinn, Nina D. Wagner‐Johnston, Marshall T. Schreeder, Jeff P. Sharman, Thomas E. Boyd, Kanti Roop, John P. Leonard, Bess Sorensen, Anthony Viggiano, Thomas M. Jahn, Richard R. Furman,

7011 Background: IDELA is a first-in-class PI3Kδ inhibitor approved in combination with rituximab for pts with relapsed CLL. Methods: Pts with R/R CLL were treated continuously with 150 mg BID oral IDELA and a limited # of cycles (C) of CIT to evaluate safety and efficacy of combination regimens. Pts could enroll in extension study after 48 wks. Responses were evaluated by published criteria (Hallek 2008; Cheson 2012). Results: 114 pts (37F/77M) median (med) age 65 (range 41-87) yrs enrolled with: extensive ...

Tópico(s): Advanced Breast Cancer Therapies

2015 - Lippincott Williams & Wilkins | Journal of Clinical Oncology

Artigo Revisado por pares

John P. Leonard, Nina D. Wagner‐Johnston, Steven Coutré, Ian W. Flinn, Marshall T. Schreeder, Nathan Fowler, Jeff P. Sharman, Ralph V. Boccia, Jacqueline C. Barrientos, Kanti Roop, Thomas E. Boyd, Richard R. Furman, Leanne Holes, David M. Johnson, Yeonhee Kim, Roger Dansey, Wayne R. Godfrey, Sven de Vos,

8500 Background: PI3K-delta signaling is critical for activation, proliferation and survival of B cells, and is hyperactive in many B-cell malignancies. Idelalisib is a first-in-class, selective, oral inhibitor of PI3Kδ that has shown considerable monotherapy activity in recurrent iNHL (Kahl, ICML 2011), as well as combination therapy (Fowler, ASCO 2012). Methods: This phase I study evaluated the activity of continuous (48 weeks) idelalisib (Id), 100/150 mg BID, in combination with rituximab (R) (375 ...

Tópico(s): PI3K/AKT/mTOR signaling in cancer

2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology

Carta Revisado por pares

Ralph Weissleder,

... SohailAkhter, Gaurav KumarJain, MahfoozurRahman, Shadab AhmadPathan, Farhan JaleesAhmad, Roop KrishenKhar2010 | Expert Opinion on Drug Delivery, Vol. 7, ... Imaging, Vol. 16, No. 1Cellular MR ImagingMichelModo, MathiasHoehn, Jeff W.M.Bulte2005 | Molecular Imaging, Vol. 4, No. ...

Tópico(s): Hepatitis B Virus Studies

1994 - Radiological Society of North America | Radiology

Artigo Acesso aberto

Jeff Borggaard, Traian Iliescu, Hyesuk Lee, John Paul Roop, Hyunjin Son,

Abstract A two‐level method for discretizing the Smagorinsky model for the numerical simulation of turbulent flows is proposed. In the two‐level algorithm, the solution to the fully nonlinear coarse mesh problem is utilized in a single‐step linear fine mesh problem. When modeling parameters are chosen appropriately, the error in the two‐level algorithm is comparable to the error in solving the fully nonlinear problem on the fine mesh. We provide an a priori error estimate for the two‐level method, ...

Tópico(s): Advanced Numerical Methods in Computational Mathematics

2007 - Wiley | PAMM

Artigo Revisado por pares

Michael J. Scott, Jeff Dagle, Krista Gaustad, M. Placet, J.M. Roop, Lawrence A. Schienbein, Carlos A. Ulibarrí,

International pressure to close some of the old nuclear reactors built by the former Soviet Union (FSU) has accelerated in the period since that country's dissolution. This pressure has been countered, however, by the argument that resulting electricity shortfalls would hasten ongoing social and economic dislocations. Under feasible economic scenarios, this paper identifies which regions would likely experience electricity supply shortfalls, outlines what adjustments in electricity transfers between ...

Tópico(s): Russia and Soviet political economy

1995 - Elsevier BV | Energy Policy