Bernard J. van Varik, Liv M Vossen, Roger Rennenberg, Jelle Stoffers, Alfons G.H. Kessels, Peter W. de Leeuw, Abraham A. Kroon,
Arterial stiffness is an important pathophysiological factor linking cardiovascular disease and kidney disease. Controversy exists as to whether arterial stiffness causes renal function decline, or kidney dysfunction leads to stiffening or whether the association is mutual. We aimed to investigate the longitudinal association between arterial stiffness and annual rate of renal function decline. We prospectively investigated in a primary care population whether carotid-femoral pulse wave velocity ( ...
Tópico(s): Sodium Intake and Health
2016 - Springer Nature | Hypertension Research
James C. Dykstra, Jelle van Oort, Ali Tafazoli Yazdi, Eric Vossen, Constantinos Patinios, John van der Oost, Diana Z. Sousa, Servé W. M. Kengen,
Abstract Background Ethyl acetate is a bulk chemical traditionally produced via energy intensive chemical esterification. Microbial production of this compound offers promise as a more sustainable alternative process. So far, efforts have focused on using sugar-based feedstocks for microbial ester production, but extension to one-carbon substrates, such as CO and CO 2 /H 2 , is desirable. Acetogens present a promising microbial platform for the production of ethyl esters from these one-carbon substrates. ...
Tópico(s): Enzyme Catalysis and Immobilization
2022 - BioMed Central | Microbial Cell Factories
Roberta Rovito, Hans-Jörg Warnatz, Szymon M. Kiełbasa, Hailiang Mei, Vyacheslav Amstislavskiy, Ramon Arens, Marie‐Laure Yaspo, Hans Lehrach, Aloys C.M. Kroes, Jelle J. Goeman, Ann C.T.M. Vossen,
Congenital Cytomegalovirus infection (cCMV) is the leading infection in determining permanent long-term impairments (LTI), and its pathogenesis is largely unknown due to the complex interplay between viral, maternal, placental, and child factors. The cellular activity, considered to be the result of the response to exogenous and endogenous factors, is captured by the determination of gene expression profiles. In this study, we determined whole blood transcriptomes in relation to cCMV, CMV viral load ...
Tópico(s): Biosensors and Analytical Detection
2018 - Public Library of Science | PLoS ONE
Jelle L. Epker, Paula van Biezen, Paul Van Daele, Teun van Gelder, Ann C.T.M. Vossen, Jan L.C.M. van Saase,
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection of the brain caused by the JC-virus. Both a decreased cellular or humoral immune response can increase the susceptibility for JC-virus induced PML. Not only HIV infected people are at risk, a wide range of otherwise immune compromised patients are a potential target for this virus. This report of five PML patients shows the importance of a clinician's familiarity with this disease and it's presenting symptoms. The presenting ...
Tópico(s): Full-Duplex Wireless Communications
2008 - Elsevier BV | European Journal of Internal Medicine
Bernard J. van Varik, Liv M Vossen, Jelle Stoffers, Abraham A. Kroon, Peter W. de Leeuw,
Objective: We aimed to prospectively investigate whether there are differences between carotid remodeling between hypertensive and normotensive people over time. Design and method: In a prospective longitudinal cohort study we compared common carotid artery ultrasonography measurements from hypertensive patients with normotensive volunteers from a single general practice. We assessed markers of arterial remodeling intima-media thickness (IMT), lumen diameter (LD), cross-sectional area (CSA), circumferential ...
Tópico(s): Blood Pressure and Hypertension Studies
2018 - Lippincott Williams & Wilkins | Journal of Hypertension
Willemijn M. Passtoors, Judith M. Boer, Jelle J. Goeman, Erik B. van den Akker, Joris Deelen, Bas J. Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H. A. M. Vossen, Jeanine J. Houwing‐Duistermaat, G.J.B. van Ommen, Rudi G. J. Westendorp, Diana van Heemst, Anton J. M. de Craen, Andrew White, David A. Gunn, Marian Beekman, P. Eline Slagboom,
The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for mRNAs whose expression changes with age and associates with longevity. We first compared gene expression profiles from whole blood samples between 50 nonagenarians ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2012 - Public Library of Science | PLoS ONE
Willemijn M. Passtoors, Judith M. Boer, Jelle J. Goeman, Erik B. van den Akker, Joris Deelen, Bas J. Zwaan, Ann Scarborough, Ruud van der Breggen, Rolf H. A. M. Vossen, Jeanine J. Houwing‐Duistermaat, G.J.B. van Ommen, Rudi G. J. Westendorp, Diana van Heemst, Anton J. M. de Craen, Andrew White, David A. Gunn, Marian Beekman, P. Eline Slagboom,
The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles.To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for mRNAs whose expression changes with age and associates with longevity.We first compared gene expression profiles from whole blood samples between 50 nonagenarians ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2012 - Public Library of Science | PLoS ONE