Stella Duffy, Val McDermid, Arcturus, Simon Barnes, John Morgan, Lauren Henderson, Gavin Lumsden, Philip Delves, James Lee Burke, Colin Tudge, George Sivell, john diamond, Geoff Brown, Louise Godfrey, Pat Gibson, Peter McKendrick, Edward James, amandip uppal, Dominic Walsh, Jonathan Hill (Political Secretary), Carol Midgley, Media Correspondent, Carol Connell, Frances Fyfileld, Peter Millar, Ian Murray, Medical Correspondent, Jenny MacArthur, Gillian Harris, Scotland Correspondent, Robert Bruce, Deborah Collcutt, Jonathan Sacks, Peter Barnard, Deborah Orombie, Ben Reed, Colin Dexter, Stephen Anderton, AO'C, Caterine Aird, Matt Dickinson, Kate Stronach, Gillian Linscott, Iain C. Baillie, Dean Ryan, Mary Ann Percy, Stephanie Billen, Ruth Rendell, Nick Szczepanik, Robert White, Jeremy Beecham (Leader of the Labour Group), John Whitehead, Media Services, Graham Searjeant, Financial Editor, Russell Jenkins, NW, Sheila Keating, Jane Owen, Walter Gammie, Ian Brodie, Mike Riplay, David Bowker, Dick Francis, Jason Cowley, Margaret Yorke, Fraser Nelson, Jrt, Tim Jones, Steve McManaman, H. R. F. Keating, Danny Baker, Mary Wings, LV, Jim Thompson, Robin Lodge, Dashiell Hammett, Charlie Porter, Reginald Hill, James Ellroy, Edward Gorman Sailing Correspondent, Colin Bateman, Phil Yates, Barney Spender, Andrew Eames, Stella Shamoon, Katherine Tanko, Brian Greer, Paul and Fearne, Andrew Morgan, Paul Hoggart, jonathan meades, Karen Woolfson, Chester Himes, Mark Timlin, Stephen McCormack, Alanna Knight, Patrick Collinson, Clive Davis, Peter Birkett, Sarah Cunningham and Fraser Nelson, Russel James, Robert B. Parker, Christine Buckley Industrial Correspondent, Robert Sheehan, D. R., Philip Kerr, Ruth Edwards, Mike Pattenden, kate muir, Janet Neel, Alan Hamilton, T. P., Simon Brett, Anne Perry, Ruth Painting, Frances Bissell, Katherine Bergen, Martin Symington, Anthony Abrahams, David Charter, Mary Loudon, lish brinkworth, Lizanne Rose, David Adams and Simon de Bruxelles, Helen Wallace, Patrica Cornwell, Elmore Leonard, Judith Wilson, L. G., Amanida Cross, The Rev Canon Hugh Wilcox, MH, Magdalen Hass, Magnus Grimond, Bill James, David Robinson, Gwendoline Butler, John Russell Taylor, Lucy Pinney, Anna Tims, Yusuf Sue Parker, Michael Pearce, S. O'connor, Carl Mortished, International Business Editor, James Sallis, Ian R. Chapman, Sarah Cunningham, Oliver August, Susan Monday, Agathe Christie, Caroline Graham, Wyn Jones, Ian Rankin, Mark Henderson and Kathryn Knight, Dominic Kennedy, Marjorie Robertson Smith, Giles Whittell, Simon De Bruxelles, Alex O'Connell, Mel Webb, Natasha Cooper, Walter Mosley, Mark Hodkinson, Edward Marston, Robert Richardson, Tim Wapshott, GB, Donald Watt, Brian Glanville, Josa Young, Graham Searjeant, Anne Ashworth Personal Finance Editor, Benedict Nightingale, Michael Connelly, Jack Bailey, Joe Warwick, Lindsey Davis, shila keating, Janet Laurence, Anjelica Goodden, Lawrence Block, Conal Gregory, Gill Hornby, Christopher Irvine, Joan Smith, mark harrison, Janet Evenovich, Mike Gerrard, Rob Hughes, Jane MacQuitty, Dorthy Simpon, Donna Leon, Richard Hobson, Ivo Tennant, Jonathan Gash, Philip Howard, Sarah Duant, James Bone, Rachel Campbell-Johnston, Charles Jencks, CP, Dorothy Sayers, Nick Nuttall, Environment Correspondent, Tony Patrick, Jonathan Kellerman, Nilgin Yusuf, Clare Stewart, Liza Cody, Philip Ridley, Lawrence Dallaglio, James Pringle and Stephen Farrell, Rupert Cox, Jill Crawxhaw, Jean-Christophe Novelli, Marcia Muller, Ruth Gledhill, Patrica Highsmith, Peter Dean, Roger Watkins, Michael Horsnell and Stewart Tendler, Jill McGown, Raymond Chandler, Robin Young, Michael Clark, Eve-Ann Prentice, Ed McBain, P. B., Elizabeth George, Lisa Jardine, VW, Alson Joseph, Nigel Williamson, Tony Hillerman, Michael Lynagh, Michael Dibdin, Robert Barnard, Raymond Keene, Laurie King, James Allcock, Jeannette Hyde, Caroline Merrell and Gavin Lumsden, Min Cooper, Patricia Cornwell, Oliver Holt, Mike Phillips, Sudi Pigott, Ruth Gledhil Religion Correspondent, Hilary Phillips, Adam Fresco, BN, Joanna Pitman, Sue Co, Sara Paretsky, Srikumar Sen Boxing Correspondent, Ellis Peters, Chris McGrath, Christopher Brookmyre, Peter Lovesey, Helen Pridham, Carl Hiaasen, Michael Gove, Jeffrey Robinson, Jane Adams, George V Higgins, Simon Jenkins, H. R. Keating, Chris Ayres, Lottie Moggach, Denise Danks, Chris Riddell, Nicholas Blincoe, Penny Perrick, Peter Robinson, Lealey Grant-Adamson, Peter Barber (Deputy Map Librarian), Susan Emmett, Jon Ashworth, Cath Urquhart, Joanna Hunter, JE, S. A, Fred Redwood, Helena Kennedy, J. W. Morrison, Christopher Somerville, Mark Souster, Nick Hawton, Andrew Taylor, Carl Mortished, david leader, Peter Wilson, Carl Evans, Alex Wijeratne, Sue Gollop, Debra Craine, George Thomas, Ian Rannkin, Maurice Jay, Jennifer Miller, James Crumpley, John Young, Keith Pike, David Hands, Helen Leudar, Martin Fletcher Chief Ireland Correspondent, Michael Cable, Derwent May, Jasper Gerard, VV, Paul Durman, PC, Lisa Grainger, Lynn Hightower, Linda Barnes, P. C. Doherty, Kathryn Kent, Peter Hillman, Mary Higgins Clark, James Prentice, Sir Arthur Conan Doyle, Adam Sage, Anabel Donald, Oliver Miles, P. W., Karina Mantavia, Caroline Merrell, Robin Neillands, Damian Whitworth, Marcel Berlins, Raw Smoked Haddock, Johan Harvey, Guy Maddin, Kenneth Ellison Davis, Kate Charles, Matthew Brace, A. E. Marston, Jane Shilling, Brian MacArthur, Jason Nissé, Denis Watkins, AS, Sue Grafton, Michelle Spring, vinny lee, steve shaw, R. D. Wingdield, Jullian Symons, Tom Rhodes, Andrew Pierce and Christopher Walker, Jill Crawshaw, David Powell, Sam Kiley, David Maddock, John Goodbody, Sports News Correspondent, Minette Walters, Nicholas Freeling, P. D. James,
... of the humble whodunnit P. D. James Liza Cody Goodbye Marple, hello Marlowe Val MeDermid on the ...
1998 - Gale Group | TDA
Shashi Prasad, Virginia Cody, Jennifer K. Saucier-Sawyer, W. Mark Saltzman, Clarence T. Sasaki, Richard L. Edelson, Martin Birchall, Douglas Hanlon,
Encapsulation of tumor-associated antigens in polymer nanoparticles (NP) is a promising approach to enhance efficiency of antigen delivery for anti-tumor vaccines. Head and neck squamous carcinoma (HNSCC) cell lines were initially used to generate tumor-associated antigens (TAA)-containing poly (lactic-co-glycolic acid) (PLGA) NP; encapsulation efficiency and release kinetics were profiled. Findings were adopted to entrap fresh tumor lysate from five patients with advanced HNSCC. To test the hypothesis ...
Tópico(s): Immune Cell Function and Interaction
2010 - Elsevier BV | Nanomedicine Nanotechnology Biology and Medicine
Stephen Johnson, John Dugdale, Ian Hislop, Stephen Fry, Nigel Andrew, Joan Bakewell, Margaret Walters, Simon Callow, Martin Fagg, Andrew Motion, Derek Cooper, Philip Skelsey, Peter Straus, Biddy Baxter, Sebastian Cody, Leonard Miall, Richard Combs, Claire Tomalin, Bob Woffinden, Dannie Abse, Paul Binding, Roger Woddis, Adrian Dannatt, Andy Medhurst, Jim Hiley, David Self, Cara Chanteau, Jeremy Siepmann, Judy Cooke, Nick Cooper, Peter Fiddick, Mark Lawson, Michael Cockerell, Satyajit Ray, Bill Grantham, John Cole, Geoffrey Hosking, Graham Fuller, Sarah Dunant, Lynne Truss, Peter Lennon, Gerald Kaufman, Peter Hennessy, Benjamin Woolley, Richard Cork, Rabbi David J. Goldberg, Swan, Martin Pacey,
... Tv High Chaperon How David Selznick stood by Jennifer Jones Watching Week What's on television in ...
1988 - Gale Group | The Listener GDA
Wei‐Jye Lin, Xiaojia Zheng, Chen-Chung Lin, Jun Tsao, Xiaolin Zhu, James J. Cody, Jennifer Coleman, Roberto Gherzi, Ming Luo, Tim M. Townes, Jacqueline N. Parker, Ching‐Yi Chen,
Inherently unstable mRNAs contain AU-rich elements (AREs) in the 3′ untranslated regions. Expression of ARE-containing type I interferon transcripts is robustly induced upon viral infection and rapidly shut off thereafter. Their transient accumulation is partly mediated through posttranscriptional regulation. Here we show that mouse embryonic fibroblasts derived from knockout mice deficient in KH-type splicing regulatory protein (KSRP), an RNA-binding protein required for ARE-mediated mRNA decay, ...
Tópico(s): RNA regulation and disease
2011 - Taylor & Francis | Molecular and Cellular Biology
Shashi Prasad, Virginia Cody, Jennifer K. Saucier-Sawyer, Tarek R. Fadel, Richard L. Edelson, Martin Birchall, Douglas Hanlon,
In order to investigate Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP) as potential vehicles for efficient tumor antigen (TA) delivery to dendritic cells (DC), this study aimed to optimize encapsulation/release kinetics before determining immunogenicity of antigen-containing NP. Various techniques were used to liberate TA from cell lines. Single (gp100) and multiple (B16-tumor lysate containing gp100) antigens were encapsulated within differing molecular weight PLGA co-polymers. Differences in ...
Tópico(s): Nanoparticle-Based Drug Delivery
2012 - Springer Science+Business Media | Pharmaceutical Research
J. Jencson, M. M. Kasliwal, J. Johansson, C. Contreras, S. Castellón, Howard E. Bond, Andrew Monson, Frank J. Masci, Ann Marie Cody, Jennifer E. Andrews, John Bally, Y. Cao, O. Fox, Timothy Gburek, R. D. Gehrz, Wayne Green, G. Hélou, E. Y. Hsiao, N. Morrell, M. M. Phillips, Thomas A. Prince, Robert A. Simcoe, Nathan Smith, Samaporn Tinyanont, R. E. Williams,
SPIRITS---SPitzer InfraRed Intensive Transients Survey---is an ongoing survey of nearby galaxies searching for infrared (IR) transients with Spitzer/IRAC. We present the discovery and follow-up observations of one of our most luminous ($M_{[4.5]} = -17.1\pm0.4$ mag, Vega) and red ($[3.6] - [4.5] = 3.0 \pm 0.2$ mag) transients, SPIRITS 15c. The transient was detected in a dusty spiral arm of IC 2163 ($D\approx35.5$ Mpc). Pre-discovery ground-based imaging revealed an associated, shorter-duration transient in the ...
Tópico(s): Stellar, planetary, and galactic studies
2017 - IOP Publishing | The Astrophysical Journal
Germán Áñez, Lisa M. Dunkle, Cynthia L. Gay, Karen L. Kotloff, Jeffrey Adelglass, Brandon Essink, James D. Campbell, Shane Cloney-Clark, Mingzhu Zhu, Joyce S. Plested, Pavitra Roychoudhury, Alexander L. Greninger, Nita Patel, Alice McGarry, Wayne Woo, Iksung Cho, Gregory M. Glenn, Filip Dubovsky, James Andersen, Szheckera Fearon, Rosa Negron, Amy Medina, Colleen Figueroa, C. Leslie Smith, Bruce Rankin, John M. Hill, Steven Shinn, Vivek Rajasekhar, Marshall Nash, Ashraf Affan, Armando Acevedo, Alina Monteagudo Can, Hector P. Rodríguez, Israel Zagales, Christine Prieto, Lizz Hernandez Diaz, Max Hale, Patrick Farr, Liesel French, Teresa Goldsmith, James Warmack, Bailey Murphy, Robyn Hartvickson, Brooke Dunlavy, Richard Glover, Amber Grant, Troy Holderman, Stacy Slechta, Terry L. Poling, Terry Klein, Thomas Klein, Tracy Klein, Sarah Pinkham, Shannen Lassiter, Imad Jandali, Maryam Belavilas, David Daniels, Katie E. Leonard, Abigail Vetter, Toni Rich, Samir Arora, Grazia Cannon, Sridhar Guduri, Alandra Lingel, Veronica Moore, Sarah Wilcox, Richard L. Gorman, Gary Horwith, Robín Masón, Laurence Chu, Michelle Listz, Lamar Box, Cindy Duran, Isaiah Knight, Katherine M. Davis, William Seger, John Villegas, Ben Seger, Virginia Loudermilk, Ruth Reyes, Anthony Kim, Wendy C Daly, Rebecca Becherer, Denver Cornett, Karen Dick, Kimberly Downs, Pamela R. Hall, Donald Brandon, William B. Davis, Daniel T. Lawler, Cindy Stevens, Karl A. Walter, Michelle Rios, Howard Schwartz, Nelia Sánchez-Crespo, Thelma Beltron, Jennifer Schwartz, Patricia Balebona, Beatriz Rivera, Bárbara Garcı́a, Christine B. Turley, Andrew McWilliams, Tiffany Esinhart, Natasha Montoya, Shamika Huskey, Leena Paul, Michael Dever, Mitul Shah, Michael S. Delgado, Tameika Scott, Patricia D. Brown, Americo Padilla, Lisa Usdan, Lora J. McGill, Valerie Arnold, Carolyn Scatamacchia, Codi M. Anthony, R. Presley, Stephan C. Sharp, Michael W. Caldwell, Linda M. Schipani, Allison Ulrich, Wendy Tidwell, Stacy Lynn Cox, Michael Levin, Julia Gass, Marcy Kulic, Eduardo D. Rodriguez, Jessica Corea, Sierra Dansbee, John Delgado, Jaleh Ostovar, Audrey Kuehl, Sarah L. Smiley, Danuel Hamlin, Ben Taucher, Cayce Tangeman, Yvonne Davis, Vanessa Armetta, Mary Sue Love, David A. Summers, J. Bruce Etheridge, Teresita Salazar, Femina David, Filipinas Vitug, Amiel Guevarra, Noemí Ramírez, Ronald Ackerman, Jamie Ackerman, Florida Aristy, Lawrence Corey, Kathleen M. Neuzil, Huub G. Gelderblom, Nzeera Ketter, Carrie Sopher, Vicki E. Miller, Amy Starr, Sonia Guerrero, Madiha Baig, Maryam Jamil, Husain Motiwala, Khozema Palanpurwala, Monica Murry, Amy Starr, Meghan Tonti, Rebecca Wischnewsky, Earl Martin, Yogesh K. Paliwal, Amit Paliwal, Sarah Gordon, Krystle Edwards, Cynthia Montano-Pereira, Michael Campos, G.H. Freeman, Esther L. Harmon, Marshall A. Cross, Kacie Sales, Catherine Q. Gular, Joseph Ley, Amanda Donoho, Kimberley Hunt, Donald J. Lewis, Stephanie Tipton, Emily Bratlee‐Whitaker, Jeffry Jacqmein, Maggie Ann Bowers, Dawn Robison, Victoria Mosteller, Janet Garvey, Carlos Fierro, Mary Easley, Amy Thompson, Heather Barker, Mazen Zari, Karol Moore, Daniel K. Finn, Lindsay Blackman, S. Block, Christal Denton, Martha Osborn, Robert J. Smith, Carl Griffin, William Schnitz, Raymond Cornelison, Linda C. Lopez, Kim Hamilton, Kim Calloway, David B. Musante, William P. Silver, Linda R. Belhorn, Nicholas A. Viens, David Dellaero, Elizabeth Wilkers, Robert Jeanfreau, N. L. Johnson, Estafania Bazan, Davilyn Roys, Steven Darden, Susan Jeanfreau, Paul Matherne, Amy Caldwell, Jessica Stahl, Nicole Guttierrez, Cassandra Beeks, Frank Eder, Ryan Little, S. E. Owen, Heather Shaw, John Tarbox, Victoia Engler, Roni Gray, Fritz Raiser, C. D. Wilson, Tiffany Nemecek, Hannah K. Harrington, Charles Harper, Torie A. Johnson, Chelsie Nutsch, Sally Eppenbach, Wendell Lewis, Katlyn Mace, Brannon C Perilloux, Christopher Dedon, Lori G. Cook, Zedlitz Zedlitz, Vasavi Srinivasan, Paige Melner, Joanna Sextor, Jessica E. Long, Francis B. Palumbo, Devon Myers, Caroline Vleck, Peter Warfield, Tatiana Beresnev, Maryam Koushkie Jahromi, Mary Marovich, Julia Hütter, Martha Nason, Mark Leibowitz, Fernanda Morales, M. Delgado, Rosario Sánchez, Norma Vega, Gary Albert, Erin Coston, Chinar Desai, Haoua Dunbar, Mark Eickhoff, Renee Entzminger-Sneed, Jenina Garcia, Margaret Kautz, Angela Lee, Maggie Lewis, Patrick Newingham, Patty Price-Abbott, Patty Reed, Kimberly Cerenze Short, Diana Vegas, Bethanie Wilkinson, Katherine R. Smith, David L. Fried, Lynne A. Haughey, Ariana C. Stanton, Monica R. Freeman, Jacqueline DiFazio, Courtney Langlois, Rosario Retino, Alexis Deniz, Wendy Paiva, Leonel Pajarillaga, Lisa Pyio, Lendy Torres, Paul Wisman, Carlos Armengol, Gemia Bouber, Peggy Bressler,
Greater than 20% of cases and 0.4% of deaths from COVID-19 occur in children. Following demonstration of the safety and efficacy of the adjuvanted, recombinant spike protein vaccine NVX-CoV2373 in adults, the PREVENT-19 trial immediately expanded to adolescents.
American Medical Association
Walter J. Rogan, Michael T. Brady, Helen J. Binns, Joel Forman, Catherine J. Karr, Kevin C. Osterhoudt, Jerome A. Paulson, James R. Roberts, Megan Sandel, James M. Seltzer, Robert O. Wright, Elizabeth H. Blackburn, Mark Anderson, Sharon A. Savage, N. Beth Ragan, Paul Spire, Joseph A. Bocchini, Henry H. Bernstein, John S. Bradley, Carrie L. Byington, Penelope H. Dennehy, Margaret C. Fisher, Robert W. Frenck, Mary P. Glodé, Harry Keyserling, David W. Kimberlin, Walter A. Orenstein, Lorry G. Rubin, Robert S. Baltimore, Julia A. McMillan, Beth P. Bell, Robert Bortolussi, Richard D. Clover, Marc Anthony Fischer, Richard L. Gorman, R. Douglas Pratt, Jennifer S. Read, Bruce G. Gellin, Jeffrey R. Starke, Jack Swanson, Carol J. Baker, Sarah S. Long, Larry K. Pickering, Edgar O. Ledbetter, H. Cody Meissner, Jennifer M. Frantz,
Drinking water for approximately one sixth of US households is obtained from private wells. These wells can become contaminated by pollutant chemicals or pathogenic organisms, leading to significant illness. Although the US Environmental Protection Agency and all states offer guidance for construction, maintenance, and testing of private wells, there is little regulation, and with few exceptions, well owners are responsible for their own wells. Children may also drink well water at child care or ...
Tópico(s): Environmental Justice and Health Disparities
2009 - American Academy of Pediatrics | PEDIATRICS
... with your doctor.AcknowledgmentWe would like to thank Jennifer Cody for her assistance with the preparation of this ...
Tópico(s): Cardiac pacing and defibrillation studies
2010 - Lippincott Williams & Wilkins | Circulation
William R. Marchand, James N. Lee, John Thatcher, Grant William Thatcher, Cody Jensen, Jennifer Starr,
Compelling evidence suggests abnormal functioning of frontal-subcortical (FSC) circuits in bipolar disorder, but it is unknown whether these are state or trait abnormalities. Longitudinal functional neuroimaging studies may help clarify this issue. However, studies to date have not determined which activation paradigms may be most useful for this purpose. A paced motor task has the potential to be more reliable than cognitive or emotional activation paradigms. To evaluate the utility of a paced motor ...
Tópico(s): Schizophrenia research and treatment
2007 - Elsevier BV | Journal of Affective Disorders
William R. Marchand, James N. Lee, John Thatcher, Grant William Thatcher, Cody Jensen, Jennifer Starr,
We used a functional magnetic resonance imaging motor activation paradigm for both hands and functional connectivity analyses to investigate motor deactivation. These analyses revealed ipsilateral (to the task) postcentral gyrus connectivity with the ipsilateral primary motor cortex as well as contralateral cerebellum for both hands. Analyses using default-mode network nodes as seed regions revealed connectivity patterns similar to previous studies of the default network and therefore provide evidence ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2007 - Elsevier BV | NeuroImage
... Arabscommunity policingcontact hypothesis Notes 1. See, for example, Cody W. Telep, Jennifer A. Varriale, Jennifer C. Gibbs, Chongmin Na and ...
Tópico(s): Wildlife Conservation and Criminology Analyses
2013 - Taylor & Francis | Israel Affairs
Jeanie L.Y. Cheong, Deanne K. Thompson, Alicia J. Spittle, Cody Potter, Jennifer Walsh, Alice Burnett, Katherine J. Lee, Jian Chen, Richard Beare, Lillian G. Matthews, Rod W. Hunt, Peter J. Anderson, Lex W. Doyle,
Tópico(s): Neonatal Respiratory Health Research
2016 - Elsevier BV | The Journal of Pediatrics
John A. Tix, Caleb T. Hasler, Cody Sullivan, Jennifer D. Jeffrey, Cory D. Suski,
Tópico(s): Environmental Toxicology and Ecotoxicology
2016 - Springer Science+Business Media | Aquatic Ecology
John A. Tix, Caleb T. Hasler, Cody Sullivan, Jennifer D. Jeffrey, Cory D. Suski,
The current study investigated the behavioural response of Lepomis macrochirus following exposures to elevated carbon dioxide (CO2 ). For this, L. macrochirus were held at ambient pCO2 (160 μatm pCO2 ) for 7 days, then exposed to elevated pCO2 (8300 μatm pCO2 ) for 5 days, and then returned to ambient conditions for a further 5 days to recover. At the end of each exposure period, several behavioural metrics were quantified (boldness, lateralization and activity). Data showed no change in lateralization and ...
Tópico(s): Parasite Biology and Host Interactions
2016 - Wiley | Journal of Fish Biology
Annie Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey,
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacking. Here, we generated traversal-deficient sporozoites by genetic disruption of sporozoite microneme protein essential for cell traversal (PfSPECT) or perforin-like protein 1 (PfPLP1). Loss of either gene did not affect P. falciparum growth in erythrocytes, ...
Tópico(s): Liver Disease Diagnosis and Treatment
2017 - Cell Press | Cell Reports
H. Pablo, Noel D. Richardson, Jim Fuller, Jason F. Rowe, A. F. J. Moffat, R. Kuschnig, Adam Popowicz, G. Handler, C. Neiner, A. Pigulski, G. A. Wade, W. W. Weiß, B. Buysschaert, Tahina Ramiaramanantsoa, A. D. Bratcher, Cody Gerhartz, Jennifer Greco, Kevin K. Hardegree-Ullman, L. Lembryk, W. L. Oswald,
ι Ori is a well-studied massive binary consisting of an O9 III + B1 III/IV star. Due to its high eccentricity (e = 0.764) and short orbital period (Porb = 29.133 76 d), it has been considered to be a good candidate to show evidence of tidal effects; however, none have previously been identified. Using photometry from the BRIght Target Explorer (BRITE)-Constellation space photometry mission, we have confirmed the existence of tidal distortions through the presence of a heartbeat signal at periastron. We combine ...
Tópico(s): Astro and Planetary Science
2017 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Simon Ferguson, Melinda Wuest, Susan Richter, Cody Bergman, Jennifer Dufour, Daniel Krys, Jennifer Simone, Hans-Sonke Jans, Terence A. Riauka, Frank Wuest,
Radiolabeled peptides play a central role in nuclear medicine as radiotheranostics for targeted imaging and therapy of cancer. We have recently proposed the use of metabolically stabilized GRPR antagonist BBN2 for radiolabeling with 18F and 68Ga and subsequent PET imaging of GRPRs in prostate cancer. The present work studied the impact of 44gSc- and 68Ga-labeled DOTA complexes attached to GRPR antagonist BBN2 on the in vitro GRPR binding affinity, and their biodistribution and tumor uptake profiles ...
Tópico(s): Neuroendocrine Tumor Research Advances
2020 - Elsevier BV | Nuclear Medicine and Biology
Madhusmita Misra, Vibha Singhal, Brian Carmine, Amita Bose, Megan M. Kelsey, Fatima Cody Stanford, Jennifer Bram, Jeremy T. Aidlen, Thomas H. Inge, Mary Bouxsein, Miriam A. Bredella,
Sleeve gastrectomy is the most commonly performed weight loss surgery in adolescents with moderate-to-severe obesity. While studies in adults have reported on the deleterious effects of gastric bypass surgery on bone structure and strength estimates, data are lacking for the impact of sleeve gastrectomy on these measures in adolescents. To evaluate the impact of sleeve gastrectomy on bone outcomes in adolescents and young adults over 12 months using dual energy X-ray absorptiometry (DXA) and high ...
Tópico(s): Diet and metabolism studies
2020 - Elsevier BV | Bone
Alison Behrman, Jennifer Cody, Samantha Elandary, Peter L. Flom, Shilpa Chitnis,
Purpose SPEAK OUT! and The LOUD Crowd is a standardized speech therapy program of 12 individual treatments combined with ongoing weekly group sessions for individuals with dysarthria due to Parkinson's disease (PD). The premise of this program is that individuals with PD must rely on goal-directed basal ganglia-cortical circuits to compensate for deficits in habitual, automatic control. The purpose of this study was to assess the outcome of this therapy program. Method Forty individuals with idiopathic ...
Tópico(s): Dysphagia Assessment and Management
2020 - American Speech–Language–Hearing Association | American Journal of Speech-Language Pathology
Cody Buntain, Jennifer Golbeck, Brooke Fisher Liu, Gary LaFree,
Twitter and other social platforms have become important communication channels during crises. While research into crisis informatics and social media is growing, the rarity of terrorist attacks in developed, Western countries complicates analysis of these specific events. To address this gap, we explore social media response to three terror events: the 2013 Boston Marathon Bombing, the 2014 Sydney Hostage Crisis, and the 2015 Charlie Hebdo Shooting. We show that, while these events do not significantly ...
Tópico(s): Terrorism, Counterterrorism, and Political Violence
2021 - | Proceedings of the International AAAI Conference on Web and Social Media
J. Matthew Hutzler, Young-Sun Yang, Daniel Albaugh, Cody L. Fullenwider, Jennifer Schmenk, Michael B. Fisher,
Substrates of aldehyde oxidase (AO), for which human clinical pharmacokinetics are reported, were selected and evaluated in pooled mixed-gender cryopreserved human hepatocytes in an effort to quantitatively characterize AO activity. Estimated hepatic clearance (Cl h ) for BIBX1382, carbazeran, O 6 -benzylguanine, zaleplon, and XK-469 using cryopreserved hepatocytes was 18, 17, 12, <4.3, and <4.3 ml · min −1 · kg −1 , respectively. The observed metabolic clearance in cryopreserved hepatocytes was confirmed to be ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2011 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Brandon K. Bellows, Cody J. Olsen, Jennifer Voelker, Curtis Wander,
The American College of Cardiology (ACC) and American Heart Association (AHA) released a new blood cholesterol treatment guideline in November 2013. It is unknown how the new recommendations have affected cholesterol medication use and adherence in a commercial health plan.To evaluate the effect of the 2013 guideline release on antihyperlipidemic treatment patterns and statin adherence in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a historical control group.This study ...
Tópico(s): Medication Adherence and Compliance
2016 - AMCP | Journal of Managed Care & Specialty Pharmacy
Laura Wray‐Lake, Cody R. DeHaan, Jennifer Shubert, Richard M. Ryan,
Civic engagement may benefit individuals who engage in it, yet empirical evidence is lacking. We examined whether civic engagement was associated with well-being in a seven-day daily diary study of 276 college students. Based on self-determination theory, we hypothesized that satisfaction of basic psychological needs mediates the link between civic engagement and well-being. Four types of civic engagement – helping, pro-environmental behavior, volunteering, and charitable giving – were examined as separate ...
Tópico(s): Nonprofit Sector and Volunteering
2017 - Routledge | The Journal of Positive Psychology
Bih‐Rong Wei, Shelley Hoover, Cody J. Peer, Jennifer E. Dwyer, Hibret A. Adissu, Priya Shankarappa, Howard H. Yang, Maxwell Lee, Tyler J. Peat, William D. Figg, R. Mark Simpson,
Melanomas arising in the mucous membranes are a rare and aggressive subtype. New treatment approaches are needed, yet accumulating sufficient evidence to improve patient outcomes is difficult. Clinical and pathological correlates between human and canine mucosal melanomas are substantial, and the relatively greater incidence of spontaneous naturally occurring mucosal melanoma in dogs represents a promising opportunity for predictive modeling. The genomic landscapes of human and canine mucosal melanoma ...
Tópico(s): Infectious Diseases and Mycology
2020 - American Association for Cancer Research | Molecular Cancer Therapeutics
Diane E. Frank, Frederick J. Schnell, Cody Akana, Saleh El-Husayni, Cody A. Desjardins, Jennifer E. Morgan, Jay S. Charleston, Valentina Sardone, Joana Domingos, George Dickson, Volker Straub, Michela Guglieri, Eugenio Mercuri, Laurent Servais, Francesco Muntoni,
Objective To report safety, pharmacokinetics, exon 53 skipping, and dystrophin expression in golodirsen-treated patients with Duchenne muscular dystrophy (DMD) amenable to exon 53 skipping. Methods Part 1 was a randomized, double-blind, placebo-controlled, 12-week dose titration of once-weekly golodirsen; part 2 is an ongoing, open-label evaluation. Safety and pharmacokinetics were primary and secondary objectives of part 1. Primary biological outcome measures of part 2 were blinded exon skipping and dystrophin ...
Tópico(s): Adipose Tissue and Metabolism
2020 - Lippincott Williams & Wilkins | Neurology
Cody S. Nelson, Jennifer A. Jenks, Norbert Pardi, Matthew L. Goodwin, Hunter Roark, W. Daniel Edwards, Jason S. McLellan, Justin Pollara, Drew Weissman, Sallie R. Permar,
Human cytomegalovirus (HCMV) is the most common infectious cause of infant birth defects, resulting in permanent neurological disability for one newborn child every hour in the United States. After more than a half century of research and development, we remain without a clinically licensed vaccine or immunotherapeutic to reduce the burden of HCMV-associated disease. In this study, we sought to improve upon the glycoprotein B protein vaccine (gB/MF59), the most efficacious HCMV vaccine evaluated in ...
Tópico(s): Parvovirus B19 Infection Studies
2020 - American Society for Microbiology | Journal of Virology
Cody Buntain, Jennifer Golbeck,
This paper explores whether trust, developed in one context, transfers into another, distinct context and, if so, attempts to quantify the influence this prior trust exerts. Specifically, we investigate the effects of artificially stimulated prior trust as it transfers across disparate contexts and whether this prior trust can compensate for negative objective information. To study such incidents, we leveraged Berg’s investment game to stimulate varying degrees of trust between a human and a set ...
Tópico(s): Game Theory and Applications
2015 - Springer Nature | Journal of Trust Management
Aleem Gangjee, Wěi Li, Roy L. Kisliuk, Vivian Cody, Jim Pace, Jennifer Piraino, Jennifer Makin,
N-{4-[(2-Amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl}-l-glutamic acid 2 and 13 nonclassical analogues 2a−2m were synthesized as potential dual thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitors and as antitumor agents. The key intermediate in the synthesis was 2-amino-6-ethyl-5-iodothieno[2,3-d]pyrimidin-4(3H)-one, 7, to which various arylthiols were attached at the 5-position. Coupling 8 with l-glutamic acid diethyl ester and saponification afforded ...
Tópico(s): Biochemical and Molecular Research
2009 - American Chemical Society | Journal of Medicinal Chemistry
Vivian Cody, Jim Pace, Jennifer Makin, Jennifer Piraino, Sherry F. Queener, A. Rosowsky,
To understand the role of specific active site residues in conferring selective dihydrofolate reductase (DHFR) inhibition from pathogenic organisms such as Pneumocystis carinii (pc) or Pneumocystis jirovecii (pj), the causative agent in AIDS pneumonia, it is necessary to evaluate the role of these residues in the human enzyme. We report the first kinetic parameters for DHFR from pjDHFR and pcDHFR with methotrexate (MTX), trimethoprim (TMP), and its potent analogue, PY957. We also report the mutagenesis ...
Tópico(s): Tuberculosis Research and Epidemiology
2009 - American Chemical Society | Biochemistry