... to the plasma membrane in human skeletal muscleCarsten Juel, Jens Jung Nielsen, and Jens Bangsbo1 April 2000 | American ...
Tópico(s): Mitochondrial Function and Pathology
1986 - American Physiological Society | Physiological Reviews
Jens Juel Christiansen, Jens Meldgaard Bruun, Jens Sandahl Christiansen, Jens Otto Lunde Jørgensen, Claus Højbjerg Gravholt,
Adrenal derived androgens are low in women with adrenal failure. The physiological consequences of substitution therapy are uncertain.To investigate the effects of DHEA substitution in women with adrenal failure on body composition, fuel metabolism, and inflammatory markers. DESIGN, PARTICIPANTS AND INTERVENTION: In this study, ten female patients (median age 38.5 years, range 28-52) with adrenal failure were treated with DHEA 50 mg for 6 months in a double-blind, randomized, placebo-controlled, ...
Tópico(s): Adipose Tissue and Metabolism
2011 - Oxford University Press | European Journal of Endocrinology
Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Jørgen Engberg, Christian Erikstrup, Morten Helms, Mie Agerbæk Juel, Jens Kjeldsen, Hans Linde Nielsen, Anna Christine Nilsson, Anne Rode, Lars Vinter‐Jensen, Christian Lodberg Hvas,
Aim: This Danish national guideline describes the treatment of adult patients with Clostridioides (formerly Clostridium) difficile (CD) infection and the use of faecal microbiota transplantation (FMT). It suggests minimum standard for implementing an FMT service.Method: Four scientific societies appointed members for a working group which conducted a systematic literature review and agreed on the text and recommendations. All clinical recommendations were evalluated for evidence level and grade of ...
Tópico(s): Gut microbiota and health
2021 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Alexandra Hott, Sigurd Liavaag, Niels Gunnar Juel, Jens Ivar Brox, Ole Marius Ekeberg,
To determine the reliability, validity, responsiveness, and interpretability of the Norwegian Anterior Knee Pain Scale (AKPS) in patients with patellofemoral pain (PFP).The AKPS was translated into Norwegian. One hundred and twelve patients with PFP participated in a randomized controlled trial. Fifty stable patients completed the AKPS at a one-week interval for test-retest reliability. Smallest detectable change (SDC) and floor/ceiling effects were evaluated. Validity and responsiveness were assessed ...
Tópico(s): Foot and Ankle Surgery
2019 - Informa | Disability and Rehabilitation
Karin Magnusson, Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kåre Birger Hagen, I.K. Haugen, Tore Julsrud Berg,
To explore whether having long-term type 1 diabetes (>45 years) is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, disability and stiffness.In total N = 96 persons with type 1 diabetes diagnosed before 1970 were included (mean [SD] age: 62.2 [7.4], mean [SD] HbA1c: 7.43 [0.80] and N = 49 [51%] men). Regular measurements of their HbA1c were obtained till 2015. We included N = 69 healthy controls without any diabetes (mean [SD] age: 63.0 [7.0], mean [SD] HbA1c: ...
Tópico(s): Pain Mechanisms and Treatments
2017 - Public Library of Science | PLoS ONE
Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kristian F. Hanssen, Dag Sigurd Fosmark, David R. Sell, Vincent M. Monnier, Tore Julsrud Berg,
We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study. We collected ...
Tópico(s): Advanced Glycation End Products research
2017 - Elsevier BV | Journal of Diabetes and its Complications
Niels Gunnar Juel, Jens Ivar Brox, Cathrine Brunborg, Kristine Bech Holte, Tore Julsrud Berg,
Objectives To compare the prevalence of shoulder disorders and self-reported shoulder disability in patients with long-term type 1 diabetes mellitus and diabetes-free subjects; and to explore the association between the long-term glycemic burden and shoulder disability in the diabetes group. Design Cross-sectional study of shoulder diagnoses with 30 years' historical data on glycemic burden in patients with diabetes. Setting Diabetics center and a university hospital. Participants Subjects attending ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2017 - Elsevier BV | Archives of Physical Medicine and Rehabilitation
Cengiz Özcan, Knud Juel, Jens Flensted Lassen, Lene von Kappelgaard, Poul Erik Mortensen, Gunnar Gislason,
Aim: The Danish Heart Registry (DHR) seeks to monitor nationwide activity and quality of invasive diagnostic and treatment strategies in patients with ischemic heart disease as well as valvular heart disease and to provide data for research. Study population: All adult ($15 years) patients undergoing coronary angiography (CAG), percutaneous coronary intervention (PCI), coronary artery bypass grafting, and heart valve surgery performed across all Danish hospitals were included. Main variables: The DHR ...
Tópico(s): Acute Myocardial Infarction Research
2016 - Dove Medical Press | Clinical Epidemiology
Alexandra Hott, Sigurd Liavaag, Niels Gunnar Juel, Jens Ivar Brox,
Patellofemoral pain syndrome (PFPS), also known as Anterior Knee Pain, is a common cause of recurrent or chronic knee pain. The etiology is considered to be multifactorial but is not completely understood. At the current time the leading theory is that pathomechanics in the patellofemoral joint leads to PFPS. Traditionally, conservative treatment has focused on improving strength and timing in the quadriceps muscles. In recent years, evidence has been accumulating to support the importance of hip ...
Tópico(s): Sports Performance and Training
2015 - BioMed Central | BMC Musculoskeletal Disorders
Kaia Beck Engebretsen, Margreth Grotle, Erik Bautz‐Holter, Ole Marius Ekeberg, Niels Gunnar Juel, Jens Ivar Brox,
Background Evidence from a recent randomized controlled trial indicated that supervised exercises (SE) were more effective than radial extracorporeal shock-wave therapy (rESWT) for the treatment of subacromial shoulder pain in the short to medium term. Little knowledge exists about the long-term results of rESWT for subacromial pain. Objective The aim of this study was to evaluate the results of rESWT and SE provided to patients with subacromial shoulder pain after 1 year. Design This was a single- ...
Tópico(s): Pain Management and Treatment
2010 - Oxford University Press | Physical Therapy
Ole Marius Ekeberg, Erik Bautz‐Holter, Anne Keller, Einar Kristian Tveitå, Niels Gunnar Juel, Jens Ivar Brox,
To compare responsiveness and minimal clinically important change (MCIC) for the disease-specific Western Ontario Rotator Cuff index (WORC) and the two region-specific questionnaires Shoulder Pain and Disability Index (SPADI) and Oxford Shoulder Scale (OSS) in patients with rotator cuff disease receiving corticosteroid injection therapy.One hundred twenty-one patients with rotator cuff disease. Western Ontario Rotator Cuff index, SPADI, and OSS were administered before treatment and at 2 and 6 weeks ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2009 - Elsevier BV | Journal of Clinical Epidemiology
Ole Marius Ekeberg, Erik Bautz‐Holter, Einar Kristian Tveitå, Anne Keller, Niels Gunnar Juel, Jens Ivar Brox,
Self-report questionnaires play an important role as outcome measures in shoulder research. Having an estimate of the measurement error of these questionnaires is of importance when assessing follow-up results after treatment and when planning intervention studies. The aim of this study was to cross-culturally adapt the Norwegian version of the OSS and WORC questionnaire and examine and compare agreement, reliability and construct validity of the disease-specific shoulder questionnaire WORC with ...
Tópico(s): Reliability and Agreement in Measurement
2008 - BioMed Central | BMC Musculoskeletal Disorders
Magni Mohr, Peter Krustrup, J. Nielsen, Lars Nybo, Martin Krøyer Rasmussen, Carsten Juel, Jens Bangsbo,
This study examined the effect of two different intense exercise training regimens on skeletal muscle ion transport systems, performance, and metabolic response to exercise. Thirteen subjects performed either sprint training [ST; 6-s sprints (n = 6)], or speed endurance training [SET; 30-s runs approximately 130% Vo(2 max), n = 7]. Training in the SET group provoked higher (P < 0.05) plasma K(+) levels and muscle lactate/H(+) accumulation. Only in the SET group was the amount of the Na(+)/H(+) exchanger isoform ...
Tópico(s): Cardiovascular and exercise physiology
2006 - American Physiological Society | AJP Regulatory Integrative and Comparative Physiology
J. Nielsen, Magni Mohr, Christina Klarskov, Michael Kristensen, Peter Krustrup, Carsten Juel, Jens Bangsbo,
A rise in extracellular potassium concentration in human skeletal muscle may play an important role in development of fatigue during intense exercise. The aim of the present study was to examine the effect of intense intermittent training on muscle interstitial potassium kinetics and its relationship to the density of Na(+),K(+)-ATPase subunits and K(ATP) channels, as well as exercise performance, in human skeletal muscle. Six male subjects performed intense one-legged knee-extensor training for ...
Tópico(s): Pharmacological Effects and Assays
2003 - Wiley | The Journal of Physiology
Rania Leventis, Gitte Juel, Jens K. Knudsen, John R. Silvius,
Acyl-CoA binding proteins (ACBPs) from rat and bovine liver were found to inhibit the nonenzymic S-acylation of two representative types of peptides by long-chain acyl-CoAs. As demonstrated previously [Quesnel, S. & Silvius, J. R. (1994) Biochemistry 33 13340−13348; Bharadwaj, M., & Bizzozero, O. A. (1995) J. Neurochem. 65, 1805−1815], peptides with the sequences myristoyl-GCG, myristoyl-GCV, and IRYCWLRR-NH2, all representing physiological S-acylation sites in mammalian proteins, become S-acylated at appreciable ...
Tópico(s): Glycosylation and Glycoproteins Research
1997 - American Chemical Society | Biochemistry
Carsten Juel, Jens Bangsbo, Terry E. Graham, Bengt Saltin,
This study examines lactate and K + fluxes from muscle to blood during and after intense exercise. Ten men performed exhaustive dynamic exercise (mean load 65 W, mean duration 3.18 min) with the knee extensors of one leg. The mean lactate efflux was 15.5 (range 8.9–24.0) mmol min ‐1 at exhaustion, and it was linearly related to the lactate gradient. A linear relationship was also obtained if the H + gradient was taken into account. Muscle pH decreased from 7.14 at rest to 6.71 (range 6.50–6.87) at exhaustion. ...
Tópico(s): Exercise and Physiological Responses
1990 - Wiley | Acta Physiologica Scandinavica
IH Zucker, Norman Levine, Gabor Kaley,
... No. 1Natriuresis induced by mild hypernatremia in humansLars Juel Andersen, Jens Lundbæk Andersen, Bettina Pump, and Peter Bie1 June ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1974 - American Physiological Society | American Journal of Physiology-Legacy Content
Thornborough, S.S. Passo, AB Rothballer,
... Cited ByNatriuresis induced by mild hypernatremia in humansLars Juel Andersen, Jens Lundbæk Andersen, Bettina Pump, and Peter Bie1 June ...
Tópico(s): Renal function and acid-base balance
1973 - American Physiological Society | American Journal of Physiology-Legacy Content
... No. 4Natriuresis induced by mild hypernatremia in humansLars Juel Andersen, Jens Lundbæk Andersen, Bettina Pump, and Peter Bie1 June ...
Tópico(s): Renal function and acid-base balance
1970 - American Physiological Society | American Journal of Physiology-Legacy Content
Jens Otto Lunde Jørgensen, Jens Juel Christensen, Esben Thyssen Vestergaard, Sanne Fisker, Per Ovesen, Jens Sandahl Christiansen,
In healthy adults insulin-like growth factor (IGF)-I levels do not differ between males and females, whereas spontaneous growth hormone (GH) secretion is approximately twofold higher in females. Untreated GH-deficient (GHD) women exhibit lower IGF-I levels compared with men and the increase in serum IGF-I during GH replacement is also significantly less. These data suggest a resistance to GH in women, which in healthy subjects is compensated for by increased GH secretion. Administration of oral oestrogen ...
Tópico(s): Adrenal Hormones and Disorders
2005 - Karger Publishers | Hormone Research in Paediatrics
Jens Juel Christiansen, Christian Djurhuus, Claus Højbjerg Gravholt, Per Ole Iversen, Jens Sandahl Christiansen, Ole Schmitz, Jørgen Weeke, Jens Otto Lunde Jørgensen, Niels Møller,
Cortisol is an important catabolic hormone, but little is known about the metabolic effects of acute cortisol deficiency.The objective of the study was to test whether clinical symptoms of weight loss, fatigue, and hypoglycemia could be explained by altered energy expenditure, protein metabolism, and insulin sensitivity during cortisol withdrawal in adrenocortical failure.We studied seven women after 24-h cortisol withdrawal and during replacement control during a 3-h basal period and a 3-h glucose ...
Tópico(s): Diet and metabolism studies
2007 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Jens Bülow, Arne Astrup, Niels Juel Christensen, Jens Kastrup,
Blood flow in skin, subcutaneous adipose tissue and skeletal muscle in the forearm of normal man during an oral glucose load. Acta Physiol Scand 130, 657–661. Received 7 November 1986, accepted 8 March 1987. ISSN 00014772. Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital and Hvidovre Hospital, Department of Medical Endocrinology, Hvidovre Hospital, and Department of Medical Endocrinology, Herlev Hospital, Copenhagen, Denmark. Blood flow to the forearm, and the subcutaneous ...
Tópico(s): Cardiovascular and exercise physiology
1987 - Wiley | Acta Physiologica Scandinavica
Jens Juel Christiansen, N.H. Andersen, Keld E. Sørensen, Erik Morre Pedersen, Eric Bennett, Marianne Andersen, Jens Sandahl Christiansen, Jens Otto Lunde Jørgensen, Claus Højbjerg Gravholt,
Summary Background Female adrenal insufficiency implicates reduced production of the adrenal androgen precursor dehydroepiandrosterone (DHEA) and low androgen levels. Oral DHEA restores androgen deficit but the clinical implications and safety of substitution therapy is uncertain. A putative DHEA receptor in vascular endothelium has been described and in vitro studies have shown involvement of DHEA in NO dependent pathways. Aim To evaluate effects of DHEA substitution on cardiovascular parameters. ...
Tópico(s): Pharmacological Effects and Assays
2007 - Wiley | Clinical Endocrinology
Jens Juel Christiansen, Sanne Fisker, Claus Højbjerg Gravholt, Eric Bennett, Birgit Svenstrup, Marianne Andersen, Ulla Feldt‐Rasmussen, Jens Sandahl Christiansen, Jens Otto Lunde Jørgensen,
Objective and design : Compared with their male counterparts, healthy females secrete more growth hormone (GH) and those with GH-deficiency have lower insulin-like growth factor I (IGF-I) levels and are less responsive to GH substitution. To test whether this gender difference is related to sex hormones we measured androgen status and IGF-I related parameters in 38 hypopituitary women (mean (range) age 41.5 (20–58) years) during continued GH substitution as compared with a control group of 38 healthy women ...
Tópico(s): Sexual Differentiation and Disorders
2005 - Oxford University Press | European Journal of Endocrinology
Jens Juel Christiansen, Claus Højbjerg Gravholt, Sanne Fisker, Niels Møller, Marianne Andersen, Birgit Svenstrup, Paul Bennett, Per Ivarsen, Jens Sandahl Christiansen, Jens Otto Lunde Jørgensen,
Objective : In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism. Design : We studied nine females with adrenal insufficiency after 9 days of oral DHEA replacement (50 mg/day) in a double-blind, placebo-controlled crossover study. Methods : Whole body and regional substrate metabolism was assayed in the basal state and during ...
Tópico(s): Adipose Tissue and Metabolism
2005 - Oxford University Press | European Journal of Endocrinology
H. Galbo, Michael E. Houston, Niels Juel Christensen, Jens J. Holst, B. Nielsen, Else Nygaard, J Suzuki,
The relationship between thermoreception, hormonal secretion and muscular activity was studied. 6 men swam 60 min in 21, 27 and 33 degrees C water at a speed requiring 68% of VO2 max (determined in 27 degrees C water). Rectal temperature increased in 33 degrees C (1.3 +/- 0.2 degrees C, mean and S.E.) and 27 degrees C (0.7+/- 0.1 degrees C) expts. but decreased in 21 degrees C expts. (0.8 +/- 0.3 degrees C). Changes in esophageal and muscle temperatures parallelled changes in rectal temperature. Plasma noradrenaline ...
Tópico(s): Adipose Tissue and Metabolism
1979 - Wiley | Acta Physiologica Scandinavica
H. Galbo, Erik A. Richter, Niels Juel Christensen, Jens J. Holst,
Abstract The importance of the sympatho‐adrenal system for the pancreatic hormonal response to exercise and, furthermore, the role of glucagon and catecholamines for the hepatic glycogen depletion during exercise were studied. Rats were either surgically adrenomedullectomized and chemically sympathectomized with 6‐hydroxydopamine or shamtreated. Two weeks later the rats had either rabbit‐antiglucagon serum or normal rabbit serum injected. Subsequently the rats either rested or swam with a tail weight ...
Tópico(s): Adipose Tissue and Metabolism
1978 - Wiley | Acta Physiologica Scandinavica
Anne‐Mette Hedeager Momsen, Diana Høtoft, Lisbeth Ørtenblad, Finn Friis Lauszus, Rubab Hassan Agha Krogh, Vibeke Lynggaard, Jens Juel Christiansen, Helle Terkildsen Maindal, Claus Vinther Nielsen,
Abstract Aims To present an overview of reviews of interventions for the prevention of diabetes in women after gestational diabetes mellitus (GDM) with the overall aim of gaining information in order to establish local interventions. Methods Six databases were searched for quantitative, qualitative or mixed‐methods systematic reviews. All types of interventions or screening programmes were eligible. The outcomes were effectiveness of reducing diabetes incidence, encouraging healthy behavioural changes ...
Tópico(s): Bariatric Surgery and Outcomes
2021 - Bioscientifica | Endocrinology Diabetes & Metabolism
Simon Winther, Samuel Emil Schmidt, Thomas Mayrhofer, Hans Erik Bøtker, Udo Hoffmann, Pamela S. Douglas, William Wijns, Jeroen J. Bax, Louise Nissen, Vibeke Lynggaard, Jens Juel Christiansen, Antti Saraste, Morten Bøttcher, Juhani Knuuti,
The prevalence of obstructive coronary artery disease (CAD) in symptomatic patients referred for diagnostic testing has declined, warranting optimization of individualized diagnostic strategies. This study sought to present a simple, clinically applicable tool enabling estimation of the likelihood of obstructive CAD by combining a pre-test probability (PTP) model (Diamond-Forrester approach using sex, age, and symptoms) with clinical risk factors and coronary artery calcium score (CACS). The new tool ...
Tópico(s): Cardiovascular Function and Risk Factors
2020 - Elsevier BV | Journal of the American College of Cardiology
Frank Schilder, Emil Bureau, Ilmar F. Santos, Jon Juel Thomsen, Jens Starke,
Noise contaminated zero problems involve functions that cannot be evaluated directly, but only indirectly via observations. In addition, such observations are affected by a non-deterministic observation error (noise). We investigate the application of numerical bifurcation analysis for studying the solution set of such noise contaminated zero problems, which is highly relevant in the context of equation-free analysis (coarse grained analysis) and bifurcation analysis in experiments, and develop specialized ...
Tópico(s): Control Systems and Identification
2015 - Elsevier BV | Journal of Sound and Vibration