Margaret Shinnie, Donald M. Lockhart, M. G. da Costa,
Tópico(s): Literary and Philosophical Studies
1984 - Wiley | Geographical Journal
Carlos Ortiz‐Hidalgo, Teresa Cuesta-Mejías, Jorge Cervantes-Castro,
... In A Voyage to Abyssinia, written by Father Jeronimo Lobo in the 17th century, based on his travels ...
Tópico(s): Therapeutic Uses of Natural Elements
2007 - SAGE Publishing | International Journal of Surgical Pathology
Tópico(s): Linguistics and Language Studies
1981 - Manchester University Press | Bulletin of the John Rylands Library
Vera Constâncio, Nuno Tiago Tavares, Rui Henrique, Cármen Jerónimo, João Lobo,
Specific cancer types face specific clinical management challenges. Owing to their stability, robustness and fast, easy and cost-effective detection, microRNAs (miRNAs) are attractive candidate biomarkers to the clinic.Based on a comprehensive review of the relevant literature in the field, we explore the potential of miRNAs as biomarkers to answer relevant clinical dilemmas inherent to cancers of the male reproductive tract (prostate [PCa], testis [TGCTs] and penis [PeCa]) and identify some of the challenges/ ...
Tópico(s): Sperm and Testicular Function
2022 - Wiley | Andrology
João Paulo Cabral, Julia Maria Schmalz Martins,
Father Jerónimo Lobo SJ was on a mission to Ethiopia between 1624 and 1634, during which he travelled on foot ...
Tópico(s): African history and culture analysis
2016 - Edinburgh University Press | Archives of Natural History
... The texts on which this study rests are Jerónimo Lobo's Itinerário and its various translations, some of ...
Tópico(s): African history and culture analysis
2011 - Taylor & Francis | Romance Studies
M. G. Da Costa (ed.): The Itinerário of Jerónimo Lobo. Translated by Donald M. Lockhart. Introduction and notes ...
1986 - Cambridge University Press | Bulletin of the School of Oriental and African Studies
Ethiopian Itineraries - The Itinerário of Jerónimo Lobo. Translated by Donald M. Lockhart from the Portuguese text established and edited by M. G. da Costa with an introduction and ...
Tópico(s): African history and culture analysis
1985 - Cambridge University Press | The Journal of African History
The Itinerário of Jerónimo Lobo. Translated by Donald M. Lockhart from the Portuguese text edited by M. G. da Costa with introduction and notes ...
Tópico(s): Historical Studies on Spain
1985 - Cambridge University Press | Journal of the Royal Asiatic Society of Great Britain & Ireland
P.E Jerónimo Lobo: Itinerário e outros escritos inéditos. Edited by M. Gonçalves da costa, in collaboration with C. F. Beckingham and ...
Tópico(s): History of Colonial Brazil
1975 - Cambridge University Press | Journal of the Royal Asiatic Society of Great Britain & Ireland
Journal Article THE “ITINERARIO” OF JERONIMO LOBO Get access C. F. BECKINGHAM C. F. BECKINGHAM Search for other works by this author on: Oxford Academic Google Scholar Journal ...
Tópico(s): African history and culture analysis
1965 - Oxford University Press | Journal of Semitic Studies
Tópico(s): Historical Studies on Spain
1982 - Routledge | Prose Studies
M. Gonçalves da Costa (ed.): P.eJerónimo Lobo: Itinerário e outros escritos inéditos. (Biblioteca Histórica de Portugal e Brasil. Série Ultra-marina.) xxviii, 832 pp., front., 16 plates. [Barcelos]: Livraria Civilização, [1971]. - Volume 37 Issue 3
Tópico(s): Historical Studies on Spain
1974 - Cambridge University Press | Bulletin of the School of Oriental and African Studies
João Lobo, Cármen Jerónimo, Rui Henrique,
In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic (chemo)therapies, given the associated short- and long-term side effects, by introducing more specific targeted therapies as single or combination agents. Due to the well-known implications of the immune system and epigenetic landscape in modulating cancer development, both have been explored as potential targets ...
Tópico(s): Histone Deacetylase Inhibitors Research
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
João Lobo, Cármen Jerónimo, Rui Henrique,
Testicular germ cell tumors share a marked sensitivity to cisplatin, contributing to their overall good prognosis. However, a subset of patients develop resistance to platinum-based treatments, by still-elusive mechanisms, experiencing poor quality of life due to multiple (often ineffective) interventions and, eventually, dying from disease. Currently, there is a lack of defined treatment opportunities for these patients that tackle the mechanism(s) underlying the emergence of resistance. Herein, ...
Tópico(s): Ovarian cancer diagnosis and treatment
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Ana Laura Costa, João Lobo, Cármen Jerónimo, Rui Henrique,
Testicular germ cell tumors (TGCT) are a group of heterogeneous, biologically diverse and clinically challenging neoplasms. Despite the relatively low incidence and mortality rates, a subgroup of patients with disseminated disease relapse after conventional therapy and have a dismal prognosis. Moreover, TGCT afflict mostly young men and have therapeutic peculiarities, with some patients showing resistance to cisplatin-based treatments and others being troubled by irreversible side effects, such as ...
Tópico(s): Histone Deacetylase Inhibitors Research
2017 - Future Medicine | Epigenomics
Nuno Tiago Tavares, Rui Henrique, Aditya Bagrodia, Cármen Jerónimo, João Lobo,
ABSTRACTIntroduction Testicular germ cell tumors (TGCT) are the most commonly diagnosed cancers among young men. Although these tumors usually have a good prognosis and are highly treatable, clinicians and pathologists still face specific dilemmas inherent to this tumor model, which is highly due to its developmental origin.Areas Covered A wide-ranging review of the currently available and future prospects in the field of TGCT biomarkers is presented.Expert Opinion The field of TGCT biomarkers has ...
Tópico(s): Sarcoma Diagnosis and Treatment
2023 - Taylor & Francis | Expert Review of Molecular Diagnostics
Produção Nacional
Revisado por pares
Vitor Pimentel Dos Santos, André Rodrigues, Gabriel Dutra, Luana Luiza Bastos, Diego Mariano, José Gutembergue de Mendonça, Yan Jerônimo Gomes Lobo, Eduardo Mazoni Andrade Marçal Mendes, Giovana Maia, Karina Machado, Adriano Velasque Werhli, Gerd B. Rocha, Leonardo Henrique França de Lima, Raquel C. de Melo-Minardi,
The SARS-CoV-2 pandemic reverberated, posing health and social hygiene obstacles throughout the globe. Mutant lineages of the virus have concerned scientists because of convergent amino acid alterations, mainly on the viral spike protein. Studies have shown that mutants have diminished activity of neutralizing antibodies and enhanced affinity with its human cell receptor, the ACE2 protein.
Tópico(s): Viral Infections and Immunology Research
2022 - PeerJ, Inc. | PeerJ
Cármen Jerónimo, Rui Henrique, Joana Oliveira, Francisco S. N. Lobo, Irene Pais, Manuel R. Teixeira, Célia Lopes,
Aims: Retinoids are involved in cell growth, differentiation, and carcinogenesis. Their effects depend on cytosolic transport and binding to nuclear receptors. CRBP1 encodes a protein involved in this process. Because altered CRBP1 expression and promoter hypermethylation occur in several tumours, these changes were investigated in prostate tumorigenesis. Methods: The CRBP1 promoter was assessed by methylation specific polymerase chain reaction on tissue samples from 36 radical prostatectomy specimens ( ...
Tópico(s): Estrogen and related hormone effects
2004 - BMJ | Journal of Clinical Pathology
Rose Slavkovsky, Pooja Bansil, Manuel Sandoval, Jacqueline Figueroa, Doris M. Rodriguez, Jose Saul Lobo, José Jerónimo, Sílvia de Sanjosé,
PURPOSE This study aims to assess the detection of cervical intraepithelial lesions grades 2 and 3 (CIN2-3) at 1 year after treatment with thermal ablation among human papillomavirus (HPV)–positive and visual inspection with acetic acid (VIA)–positive women. METHODS All women screened and triaged for cervical cancer at four government health facilities in Honduras who were eligible for ablative treatment were enrolled and treated with thermal ablation. Women with confirmed CIN2-3 and a subset of women ...
Tópico(s): Reproductive tract infections research
2020 - Lippincott Williams & Wilkins | JCO Global Oncology
João Lobo, Ricardo Leão, Cármen Jerónimo, Rui Henrique,
Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we provide an overall review of the current liquid biopsy-based biomarkers of this disease, including ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Sara Monteiro‐Reis, João Lobo, Rui Henrique, Cármen Jerónimo,
Bladder cancer is one of the most incident neoplasms worldwide, and its treatment remains a significant challenge, since the mechanisms underlying disease progression are still poorly understood. The epithelial to mesenchymal transition (EMT) has been proven to play an important role in the tumorigenic process, particularly in cancer cell invasiveness and metastatic potential. Several studies have reported the importance of epigenetic mechanisms and enzymes, which orchestrate them in several features ...
Tópico(s): Ferroptosis and cancer prognosis
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
João Lobo, Ad Gillis, Cármen Jerónimo, Rui Henrique, Leendert H. J. Looijenga,
Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibility as well as environmental factors in the pathogenesis, referred to as ‘genvironment’. Moreover, it could also explain various epidemiological findings, including the rising incidence of this type of cancer ...
Tópico(s): Renal and related cancers
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
João Lobo, Rui Henrique, Cármen Jerónimo,
It is well established that cancer cells exhibit alterations in chromatin structure and accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic activity (DNA and histone-modifying enzymes) and chromatin remodelers have been depicted in various tumor models in recent years. Still, little attention has been directed towards testicular germ cell tumors (TGCTs)—representing the most common neoplasm among young adult Caucasian men—with most studies focusing on exploring the ...
Tópico(s): Histone Deacetylase Inhibitors Research
2018 - Multidisciplinary Digital Publishing Institute | Cancers
Nuno Tiago Tavares, Saulė Gumauskaitė, João Lobo, Cármen Jerónimo, Rui Henrique,
Platinum-based chemotherapy is routinely used for the treatment of several cancers. Despite all the advances made in cancer research regarding this therapy and its mechanisms of action, tumor resistance remains a major concern, limiting its effectiveness. DNA methylation-based biomarkers may assist in the selection of patients that may benefit (or not) from this type of treatment and provide new targets to circumvent platinum chemoresistance, namely, through demethylating agents. We performed a systematic ...
Tópico(s): Ferroptosis and cancer prognosis
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Produção Nacional
Revisado por pares
Maila de Castro Lourenço das Neves, Ananda A. Teixeira, Flávia M. Garcia, Joel Rennó, Antônio Geraldo da Silva, Amaury Cantilino, Carlos Eduardo da Rosa, Jeronimo de A. Mendes-Ribeiro, Renan Rocha, Hewdy Ribeiro Lobo, Igor Emanuel Vasconcelos e Martins Gomes, Christiane Carvalho Ribeiro, Fréderico Duarte Garcia,
To systematically review the literature focusing on obstetric and perinatal outcomes in women with previous or current eating disorders (EDs) and on the consequences of maternal EDs for the offspring.The study was performed following the systematic review and meta-analysis (PRISMA) statement. PubMed, SciELO, and Cochrane databases were searched for non-interventional studies published in English or Portuguese from January 1980 to December 2020. Risk of bias was assessed using the Methods guide for ...
Tópico(s): Obesity and Health Practices
2021 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
... de traduire et de publier la relation de Jeronimo Lobo (1595-1678), manuscrit decouvert dans la bibliotheque du ...
Tópico(s): Historical Influence and Diplomacy
2015 - Presses Universitaires De France | Dix-septième siècle
... access DONALD M. LOCKHART (tr.), The Itinerario of Jeronimo Lobo translated from the Portuguese text edited by M. ...
Tópico(s): African history and culture analysis
1984 - Oxford University Press | Journal of Semitic Studies
... by the missionaries Francisco Alvares, Pedro Paez, and Jeronimo Lobo, in the last half of the sixteenth and ...
Tópico(s): Global Maritime and Colonial Histories
1916 - Wiley | Geographical Journal
Vera L. Costa, Rui Henrique, Franclim R. Ribeiro, João Carvalho, Jorge Oliveira, Francisco S. N. Lobo, Manuel R. Teixeira, Cármen Jerónimo,
Constitutive activation of the Wnt signaling pathway is a common feature of solid tumors and contributes to uncontrolled cell-growth and impaired differentiation. We hypothesized that gene silencing mediated through aberrant promoter methylation of upstream Wnt antagonist genes might result in β-catenin accumulation, resulting in constitutive Wnt activation. Wnt antagonist genes (SFRP1, WIF1, APC and CDH1) and CTNNB1 promoter methylation was examined in genomic DNA extracted from 12 urological cancer ...
Tópico(s): Cancer-related gene regulation
2010 - Landes Bioscience | Epigenetics