Produção Nacional
Revisado por pares
Jezrael Rossetti Dutra, Sérgio Luiz Moni Ribeiro Filho, André Luis Christofóro, Túlio Hallak Panzera, Fabrizio Scarpa,
A full factorial design is performed to investigate a sandwich structure consisted of Piassava fibre laminates as face sheets and epoxy-based honeycomb cores containing eucalyptus sawdust and cement particles. A three-point bending test is used to evaluate the composite structure. The composite setup which achieves higher flexural modulus and strength is used as honeycomb core material. Finite element models are developed to predict the failure and the elastic flexural properties of the sandwich ...
Tópico(s): Bamboo properties and applications
2019 - Elsevier BV | Thin-Walled Structures
Yan Li, Jezrael L. Revalde, James W. Paxton,
Membrane transporter proteins (the ABC transporters and SLC transporters) play pivotal roles in drug absorption and disposition, and thus determine their efficacy and safety. Accumulating evidence suggests that the expression and activity of these transporters may be modulated by various phytochemicals (PCs) found in diets rich in plants and herbs. PC absorption and disposition are also subject to the function of membrane transporter and drug metabolizing enzymes. PC–drug interactions may involve ...
Tópico(s): Cholesterol and Lipid Metabolism
2016 - Elsevier BV | Advanced Drug Delivery Reviews
Jezrael L. Revalde, Yan Li, Bill C. Hawkins, Rhonda J. Rosengren, James W. Paxton,
Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5). The use of CUR in the clinic however, is complicated by its instability and poor pharmacokinetic profile. Monocarbonyl analogs of CUR (MACs) are compounds without CUR's unstable β-diketone moiety and were reported to have improved ...
Tópico(s): Metal complexes synthesis and properties
2014 - Elsevier BV | Biochemical Pharmacology
Yan Li, Jezrael L. Revalde, Glen Reid, James W. Paxton,
Tópico(s): Curcumin's Biomedical Applications
2010 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Yan Li, Jezrael L. Revalde, Glen Reid, James W. Paxton,
Common foods, such as fruits and vegetables, contain a large variety of secondary metabolites known as phytochemicals, many of which have been associated with health benefits. However, there is a limited knowledge of the processes by which these, mainly charged, phytochemicals (and/or their metabolites) are absorbed into the body, reach their biological target, and how they are eliminated. Recent studies have indicated that some of these phytochemicals are substrates and modulators of specific members ...
Tópico(s): Metal complexes synthesis and properties
2010 - Taylor & Francis | Drug Metabolism Reviews
Jezrael L. Revalde, Yan Li, Tissa Wijeratne, Piyush Bugde, Bill C. Hawkins, Rhonda J. Rosengren, James W. Paxton,
Our group investigated combining the phytochemical curcumin and gemcitabine in a liposome, to improve gemcitabine's activity against pancreatic tumours. While optimising the curcumin: gemcitabine ratio for co-encapsulation, we found that increasing curcumin concentrations relative to gemcitabine resulted in antagonistic interactions. As curcumin is a promiscuous transporter inhibitor; we suspected that increased resistance occurred via inhibition of Equilibrative nucleoside transporter 1 (ENT1)-mediated ...
Tópico(s): Adenosine and Purinergic Signaling
2017 - Elsevier BV | European Journal of Pharmacology
Lin Xiao, Mawar Karsa, Emma Ronca, Angelika Bongers, Angelika Kosciolek, Ali El‐Ayoubi, Jezrael L. Revalde, Janith A. Seneviratne, Belamy B. Cheung, Laurence C. Cheung, Rishi S. Kotecha, Andrea Newbold, Stefan Bjelosevic, Greg M. Arndt, Richard B. Lock, Ricky W. Johnstone, Andrei V. Gudkov, Katerina V. Gurova, Michelle Haber, Murray D. Norris, Michelle J. Henderson, Klaartje Somers,
Rearrangements of the Mixed Lineage Leukemia ( MLL/KMT2A ) gene are present in approximately 10% of acute leukemias and characteristically define disease with poor outcome. Driven by the unmet need to develop better therapies for KMT2A-rearranged leukemia, we previously discovered that the novel anti-cancer agent, curaxin CBL0137, induces decondensation of chromatin in cancer cells, delays leukemia progression and potentiates standard of care chemotherapies in preclinical KMT2A-rearranged leukemia models. ...
Tópico(s): Acute Myeloid Leukemia Research
2022 - Frontiers Media | Frontiers in Oncology
Samuel Sander Carvalho, Jezrael Rossetti Dutra, André Cerávolo de Carvalho, Luciano Machado Gomes Vieira, André Luis Christofóro,
Timber is the oldest construction materials in the world, have been widely used in structures in addition to having a high longevity, if treated properly (maintenance). If this does not occur, the wood deteriorates due to the action of insects, fungi and other aggressive agents. There are several materials and techniques used to reinforce the damaged parts. This paper presents an experimental study of Eucalyptus grandis and Pinus elliiottii timber beams reinforced with sisal fibres laminated composite ...
Tópico(s): Bamboo properties and applications
2012 - | International journal of composite materials
Dina Buitrago Silva, Marena Trinidad, Alicia Ljungdahl, Jezrael L. Revalde, Geoffrey Y. Berguig, W.E. Wallace, C. Patrick, Lorenzo Bomba, Michelle R. Arkin, Shan Dong, Karol Estrada, Keino Hutchinson, Jonathan H. LeBowitz, Avner Schlessinger, Katrine M. Johannesen, Rikke S. Møller, Kathleen M. Giacomini, Steven Froelich, Stephan Sanders, Arthur Wüster,
Heterozygous variants in SLC6A1, encoding the GAT-1 GABA transporter, are associated with seizures, developmental delay, and autism. The majority of affected individuals carry missense variants, many of which are recurrent germline de novo mutations, raising the possibility of gain-of-function or dominant-negative effects. To understand the functional consequences, we performed an in vitro GABA uptake assay for 213 unique variants, including 24 control variants. De novo variants consistently resulted ...
Tópico(s): Genomics and Rare Diseases
2024 - Elsevier BV | The American Journal of Human Genetics
Produção Nacional
Revisado por pares
... nosso artigo apresenta a historia do vale de Jezrael considerado hoje um local muito importante para a ...
Tópico(s): Archaeology and Historical Studies
2015 - UNIVERSIDADE METODISTA DE SÃO PAULO | Caminhando
Produção Nacional
Revisado por pares
... Monte Tabor e o outro no Vale de Jezrael. Com o advento da Escrita, Israel Norte produziu ...
Tópico(s): Ancient Egypt and Archaeology
2020 - Editora da Pontifícia Universidade Católica do Rio Grande do Sul (EDIPUCRS) | Teocomunicação
... Movement, 1910–1948 Michal Man (Max Stern Emek Jezrael College) Shifra Shvarts (Ben Gurion University) Early Detection ...
Tópico(s): Historical Psychiatry and Medical Practices
2009 - Johns Hopkins University Press | Bulletin of the history of medicine
... Clete Shannon in pursuit of a vicious killer, Jezrael Dushane. At the same time. Goodwin falls in ...
Tópico(s): American Literature and Culture
1995 - University of Nebraska Press | Western American literature
Tyler C. Detomasi, Gilles Degotte, Sijie Huang, Rahul K. Suryawanshi, Amy Diallo, Luca Lizzadro, Francisco J. Zaptero-Belinchón, Taha Y. Taha, Jiapeng Li, Alicia Richards, Eric R. Hantz, Zain Alam, Mauricio Montaño, Maria McCavitt-Malvido, R. Gumpena, James R. Partridge, G.J. Correy, Yusuke Matsui, Annemarie F. Charvat, Isabella Glenn, Julia Rosecrans, Jezrael L. Revalde, David J. Anderson, Judd F. Hultquist, Michelle R. Arkin, R. Jeffrey Neitz, Danielle L. Swaney, Nevan J. Krogan, Brian K. Shoichet, Kliment A. Verba, Mélanie Ott, Adam R. Renslo, Charles S. Craik,
Tópico(s): Animal Virus Infections Studies
2025 - American Association for the Advancement of Science | Science Advances
Kevin Wilkins, Till Schroeder, Sohyun Gu, Jezrael L. Revalde, Stephen N. Floor,
DDX3X regulates the translation of a subset of human transcripts containing complex 5′ untranslated regions (5′ UTRs). In this study, we developed the helicase activity reporter for translation (HART), which uses DDX3X-sensitive 5′ UTRs to measure DDX3X-mediated translational activity in cells. To directly measure RNA structure in DDX3X-dependent mRNAs, we used SHAPE-MaP to determine the secondary structures present in DDX3X-sensitive 5′ UTRs and then used HART to investigate how sequence alterations ...
Tópico(s): RNA Research and Splicing
2024 - Cold Spring Harbor Laboratory Press | RNA
Carlos D. Ramos-Villanueva, Guadalupe Carrillo-Benítez, Erika Janet Zamora-Macorra, Eduardo Santiago-Elena, Samuel Ramírez–Alarcón, Jezrael Jimenez-Vidals, Ricardo Ávila-López,
The Tomato brown rugose fruit virus (ToBRFV) is one of the main pathogens affecting tomato crops in Mexico. Despite efforts to prevent its spread, it is nearly impossible due to its low transmission percentage through seeds and its high susceptibility to being transmitted through cultural practices. Therefore, alternative management strategies are being sought. This research aimed to determine the effect of endophytic microorganisms applied to the soil on tomato plants infected with ToBRFV. A tomato ...
Tópico(s): Nematode management and characterization studies
2023 - | Revista mexicana de fitopatología(en línea)/Revista mexicana de fitopatología
Produção Nacional
Hálisson Alves Ribeiro, Jezrael Rossetti Dutra, Flávia Cláudia Silva, Ian Mazzetti Rodrigues Valle, Flávio de Souza Araújo, Fabíola Bertú Medeiros, Rodrigo Gustavo da Silva Carvalho,
O objetivo do presente estudo foi analisar o efeito da facilitação neuromuscular proprioceptiva (FNP), realizada em meio terrestre e aquático, na flexibilidade de posteriores da coxa e extensores do quadril em adultos saudáveis. Trata-se de um ensaio clínico aleatorizado. A amostra foi composta por 16 adultos (18 a 35 anos) de ambos os sexos, randomizados em dois grupos: experimental (GE, n=08), submetido ao alongamento por FNP no meio aquático; e controle (GC, n=08), que recebeu a FNP no meio terrestre. ...
Tópico(s): Children's Physical and Motor Development
2022 - UNIVERSIDADE CESUMAR | Saúde e Pesquisa
Nicole M. Haynes, Theresa Connor, Ben Morrow, Judy P. Doherty, Matthew L. Dennis, Jonathan G. Hubert, Sukhdeep K. Spall, Anthony N. Cuzzupe, Karen H. White, Susan A. Charman, Aaron Lock, Vicky M. Avery, Stewart D. Nuttall, Thomas S. Peat, Olan Dolezal, Pat Pilling, Jezrael L. Revalde, Tin T. Yow, Greg M. Arndt, Hendrik Falk, Mark Devlin, Ian P. Street, Poh Sim Khoo, Paul A. Stupple, Brendon Monahan,
Tópico(s): Peptidase Inhibition and Analysis
2019 - BMJ | Journal for ImmunoTherapy of Cancer