Produção Nacional
Revisado por pares
Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, Ermerson Vieira dos Santos, Thais Lima Ferreira, Tatiana do Nascimento Paiva Coutinho, Lara Elloyse Almeida Moreira, Rosana de Sousa Campos, Claudia Roberta de Andrade, Wildson Max Barbosa da Silva, Igor de Sá Carneiro, Jacilene Silva, Hélcio Silva dos Santos, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, João Batista de Andrade Neto,
Introduction.Candida spp. are commensal fungal pathogens of humans, but when there is an imbalance in the microbiota, or weak host immunity, these yeasts can become pathogenic, generating high medical costs.Gap Statement. With the increase in resistance to conventional antifungals, the development of new therapeutic strategies is necessary. This study evaluated the in vitro antifungal activity of chlorogenic acid against fluconazole-resistant strains of Candida spp. Mechanism of action through flow ...
Tópico(s): Fungal Infections and Studies
2022 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
João Batista de Andrade, Evaldo Ferrari, Rosana Aparecida Possenti, Ivani Pozar Otsuk, Léo Zimback, Marcos Guimarães de Andrade Landell,
Foi desenvolvido, em 1999/2000, no Instituto de Zootecnia, em Nova Odessa (SP), um experimento para avaliar 60 genótipos de cana-de-açúcar (24 cultivares e 36 clones), para fins de alimentação animal. O experimento foi executado em delineamento de blocos ao acaso, com três repetições. Os genótipos foram amostrados aos 12 e 18 meses de idade. Para todas as características analisadas: porcentagem de matéria seca (%MS); de proteína bruta (%PB); de extrato etéreo (%EE); de matéria mineral (%MM); de carboidratos ...
Tópico(s): Natural Products and Biological Research
2004 - INSTITUTO AGRONÔMICO DE CAMPINAS | Bragantia
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Cecília Rocha da Silva, Maria A. S. Neta, Rosana de Sousa Campos, Janaína T. Siebra, Rose A. C. Silva, Danielle S. Macêdo, Hemerson Iury Ferreira Magalhães, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles B. Grangeiro, Tatiane S. C. Carvalho, Emilay B. T. Diogo, Eufrânio N. da Silva Júnior, Felipe Augusto Rocha Rodrigues, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause of morbidity and mortality; in addition, they prolong hospital stays and raise the costs associated with treatment. Studies have reported a significant increase in infections by non-albicans Candida species, especially C. tropicalis. The number of antifungal drugs on the market is small in comparison to the number of antibacterial agents available. The limited ...
Tópico(s): Cancer therapeutics and mechanisms
2014 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Cecília Rocha da Silva, João Batista de Andrade Neto, Rosana de Sousa Campos, Narjara Silvestre Figueiredo, Sandro Serpa, Hemerson Iury Ferreira Magalhães, Bruno C. Cavalcanti, Danielle S. Macêdo, Geanne Matos de Andrade, Iri Sandro Pampolha Lima, Glauce Socorro de Barros Viana, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles B. Grangeiro, Hélio Vitoriano Nobre Júnior,
ABSTRACT Flavonoids are a class of phenolic compounds commonly found in fruits, vegetables, grains, flowers, tea, and wine. They differ in their chemical structures and characteristics. Such compounds show various biological functions and have antioxidant, antimicrobial, anti-inflammatory, and antiapoptotic properties. The aim of this study was to evaluate the in vitro interactions of flavonoids with fluconazole against Candida tropicalis strains resistant to fluconazole, investigating the mechanism ...
Tópico(s): Essential Oils and Antimicrobial Activity
2013 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
Cecília Rocha da Silva, João Batista de Andrade Neto, José Júlio Costa Sidrim, Maria Rozzelê Ferreira Ângelo, Hemerson Iury Ferreira Magalhães, Bruno C. Cavalcanti, Raimunda Sâmia Nogueira Brilhante, Danielle S. Macêdo, Manoel Odorico de Moraes, Marina Duarte Pinto Lobo, Thalles B. Grangeiro, Hélio Vitoriano Nobre Júnior,
ABSTRACT There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. Combination drug therapies have become one of the most widely used and effective strategies to alleviate this problem. Amiodarone (AMD) ...
Tópico(s): Plant-Microbe Interactions and Immunity
2013 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
João Batista de Andrade, Evaldo Ferrari Júnior, Gilberto Braun,
O objetivo deste trabalho foi determinar o valor nutritivo da silagem de cana-de-açúcar tratada com 0,5% de uréia e acrescida de 0, 40, 80 e 120 kg de rolão-de-milho/t de cana-de-açúcar picada e ensilada. O experimento foi desenvolvido no Instituto de Zootecnia, em Nova Odessa, SP, em delineamento de blocos completos ao acaso com quatro repetições. O teste de consumo e digestibilidade foi efetuado com ovelhas em gaiolas com coletor e separador de fezes e urina. O teste constou de três períodos de ...
Tópico(s): Agroforestry and silvopastoral systems
2001 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Rose Anny Costa Silva, Cecília Rocha da Silva, João Batista de Andrade Neto, Anderson Ramos da Silva, Rosana Sousa Campos, Sandro Serpa, Francisca Bruna Stefany Aires do Nascimento, Brenda da Silva Gaspar, Said Gonçalves da Cruz Fonseca, Maria Aparecida Alexandre Josino, Thalles B. Grangeiro, Danielle S. Macêdo, David Freitas de Lucena, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Recent research has shown broad antifungal activity of the classic antidepressants selective serotonin reuptake inhibitors (SSRIs). This fact, combined with the increased cross-resistance frequency of the genre Candida regarding the main treatment today, fluconazole, requires the development of novel therapeutic strategies. In that context, this study aimed to assess the antifungal potential of fluoxetine, sertraline, and paroxetine against fluconazole-resistant Candida spp. planktonic cells, as ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2017 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Maria Aparecida Alexandre Josino, Cecília Rocha da Silva, Rosana de Sousa Campos, Francisca Bruna Stefany Aires do Nascimento, Sandro Serpa, Lívia Gurgel do Amaral Valente Sá, Igor de Sá Carneiro, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Jacó Ricarte Lima de Mesquita, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
Emergence of methicilin resistant Staphylococcus aureus (MRSA) strains is a major cause of infirmity worldwide and has limited our therapeutic options against these pathogens. In this regard, the search for candidates with an antimicrobial activity, with a greater efficacy and a lower toxicity, is necessary. As a result, there is greater need to search for resistance modifying agents which, in combination with existing drugs, will restore the efficacy of these drugs. The antibacterial effect of fluoxetine ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2018 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Yunierkis Pérez‐Castillo, Tamires Cardoso Lima, Alana Rodrigues Ferreira, Cecília Rocha da Silva, Rosana de Sousa Campos, João Batista de Andrade Neto, Hemerson Iury Ferreira Magalhães, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior, Damião Pergentino de Sousa,
Over the last decade, there has been a dramatic increase in the prevalence and gravity of systemic fungal diseases. This study aimed therefore at evaluating the antifungal potential of ester derivatives of benzoic and cinnamic acids from three Candida species. The compounds were prepared via Fischer esterification, and the antifungal assay was performed by the microdilution method in 96-well microplates for determining the minimal inhibitory concentrations (MICs). The findings of the antifungal tests ...
Tópico(s): Phytochemicals and Antioxidant Activities
2020 - Hindawi Publishing Corporation | BioMed Research International
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Vitória Pessoa de Farias Cabral, Lavouisier Frankilin Brito Nogueira, Cecília Rocha da Silva, Lívia Gurgel do Amaral Valente Sá, Anderson Ramos da Silva, Wildson Max Barbosa da Silva, Jacilene Silva, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
Staphylococcus aureus is a commensal bacterium and opportunistic human pathogen that can cause a wide variety of clinical infections. It is recognized for its ability to acquire antimicrobial resistance, so methicillin-resistant Staphylococcus aureus (MRSA) infections are a global healthcare challenge. Therefore, the development of new therapeutic options and alternative therapies for treatment is necessary. Curcumin, a polyphenolic substance found in the rhizome of turmeric longa L, has been shown ...
Tópico(s): Oral microbiology and periodontitis research
2021 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Anderson Ramos da Silva, João Batista de Andrade Neto, Cecília Rocha da Silva, Rosana de Sousa Campos, Rose Anny Costa Silva, Daniel Domingues Freitas, Francisca Bruna Stefany Aires do Nascimento, Larissa Nara Dantas de Andrade, Sandro Serpa, Thalles B. Grangeiro, Hemerson Iury Ferreira Magalhães, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
The incidence of fungal infections and, in particular, the incidence of fungal antibiotic resistance, which is associated with biofilm formation, have significantly increased, contributing to morbidity and mortality. Thus, new therapeutic strategies need to be developed. In this context, natural products have emerged as a major source of possible antifungal agents. Berberine is a protoberberine-type isoquinoline alkaloid isolated from the roots, rhizomes, and stem bark of natural herbs, such as ...
Tópico(s): Probiotics and Fermented Foods
2016 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Produção Nacional
Revisado por pares
João Batista de Andrade Neto, Cecília Rocha da Silva, Fátima Daiana Dias Barroso, Lívia Gurgel do Amaral Valente Sá, Rosana de Sousa Campos, Francisca Bruna Stefany Aires do Nascimento, Sandro Serpa, Anderson Ramos da Silva, Lisandra Juvêncio da Silva, Igor de Sá Carneiro, Helaine Almeida Queiroz, Jacó Ricarte Lima de Mesquita, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior,
The emergence of Candida spp. with resistance to antifungal molecules, mainly the azole class, is an increasing complication in hospitals around the globe. Aim: In the present research, we evaluated the synergistic effects of ketamine with two azole derivatives, itraconazole and fluconazole, on strains of Candida spp. to fluconazole. Materials & methods: The drug synergy was evaluated by quantifying the fractional inhibitory concentration index and by fluorescence microscopy and flow cytometry techniques. ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2020 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Francisca Bruna Stefany Aires do Nascimento, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Jacilene Silva, Emmanuel Silva Marinho, Manoel Odorico de Moraes, Maria Erivanda França Rios, Bruno C. Cavalcanti, Iri Sandro Pampolha Lima, Hélio Vitoriano Nobre Júnior,
This study evaluated the effect of etomidate against biofilms of Candida spp. and analysed through molecular docking the interaction of this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: Candida albicans, Candida parapsilosis and Candida tropicalis. Growing biofilms were exposed to etomidate at 31.25-500 µg ml-1. Then, an ALS3 adhesive protein from C. albicans was analysed through a molecular mapping technique, composed of a sequence of algorithms ...
Tópico(s): Fungal Infections and Studies
2020 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
Emanuelle Machado Marinho, João Batista de Andrade Neto, Jacilene Silva, Cecília Rocha da Silva, Bruno C. Cavalcanti, Emmanuel Silva Marinho, Hélio Vitoriano Nobre Júnior,
Coronavirus (COVID-19) is an enveloped RNA virus that is diversely found in humans and that has now been declared a global pandemic by the World Health Organization. Thus, there is an urgent need to develop effective therapies and vaccines against this disease. In this context, this study aimed to evaluate in silico the molecular interactions of drugs with therapeutic indications for treatment of COVID-19 (Azithromycin, Baricitinib and Hydroxychloroquine) and drugs with similar structures (Chloroquine, ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Ricardo Pini Caramit, Adriana Garabini de Freitas Andrade, João Batista Gomes de Souza, Tatiane Alfonso de Araújo, Luíz Henrique Viana, Magno Aparecido Gonçalves Trindade, Valdir Souza Ferreira,
An electroanalytical method for the simultaneous detection and quantification of tert-butylhydroquinone (TBHQ) and butyl hydroxyanisole (BHA) in biodiesel was developed using a voltammetric technique and screen-printed electrodes. The supporting electrolyte solution was composed of Britton–Robinson buffer (0.04 mol L−1) containing methanol (2.0%) and the cationic surfactant cetyltrimethylammonium bromide (CTAB). In the presence of CTAB, the peak current intensity and voltammetric resolution increased ...
Tópico(s): Analytical Chemistry and Sensors
2012 - Elsevier BV | Fuel
Produção Nacional
Revisado por pares
João Batista de Andrade, Evaldo Ferrari, Rosana Aparecida Possenti, Ivani Pozar Otsuk, Léo Zimback, Marcos Guimarães de Andrade Landell,
totais não estruturais, teor de fibra insolúvel em detergente neutro e degradabilidade efetiva da matéria seca.Levando-se em conta apenas a qualidade e degradabilidade foram selecionados os grupos 6, 7, 8, 9 e 10.Incluindo na avaliação, a produção de matéria seca, os grupos selecionados foram os de número 6, 8 e 9.
Tópico(s): Genetics and Plant Breeding
2003 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Veterinary Research and Animal Science
Produção Nacional
Revisado por pares
Leandro do Prado Ribeiro, José Djair Vendramim, Keylla U. Bicalho, Moacir dos Santos Andrade, João Batista Fernandes, Rafael de Andrade Moral, Clarice Garcia Borges Demétrio,
New control methods are necessary for stored grain pest management programs due to both the widespread problems of insecticide-resistance populations and the increasing concerns of consumers regarding pesticide residues in food products. Thus, this study evaluated the bioactivity of extracts and fractions obtained from different structures (leaves, branches, and seeds) of Annona mucosa (Annonaceae) against Sitophilus zeamais (Coleoptera: Curculionidae), which is a primary insect pest of stored cereals ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2013 - Elsevier BV | Journal of Stored Products Research
Produção Nacional
Revisado por pares
Anderson Ramos da Silva, Hélio Vitoriano Nobre Júnior, Sandro Serpa, Francisca Bruna Stefany Aires do Nascimento, Cecília Rocha da Silva, João Batista de Andrade Neto, Ángeles Manresa, Aurora Pinazo, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Iñaki Ruiz‐Trillo, Meritxell Antó, M. Carmen Morán, Lourdes Pérez,
Nowadays, infections caused by fungi and protists constitute a serious problem for public health services. The limited number of treatment options coupled with the increasing number of resistant microorganisms makes necessary the development of new non-toxic antifungal and antiprotozoal agents. Cationic amino acid-based rhamnolipids have been recently prepared by our group and exhibited good antibacterial activity. In this work, the antifungal, antibiofilm and antiprotozoal activity of these new ...
Tópico(s): Legionella and Acanthamoeba research
2020 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Produção Nacional
Revisado por pares
Lisandra Juvêncio da Silva, Fátima Daiana Dias Barroso, Lucas Sousa Vieira, Daniel Roberto Carlos Mota, Bruna Kelly da Silva Firmino, Cecília Rocha da Silva, Vitória Pessoa de Farias Cabral, Thiago M Cândido, Lívia Gurgel do Amaral Valente Sá, Wildson Max Barbosa da Silva, Jacilene Silva, Emmanuel Silva Marinho, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, João Batista de Andrade Neto,
The genus Candida spp. has been highlighted as one of the main etiological agents causing fungal infections, with Candida albicans being the most prominent, responsible for most cases of candidemia. Due to its capacity for invasion and tissue adhesion, it is associated with the formation of biofilms, mainly in the environment and hospital devices, decreasing the effectiveness of available treatments. The repositioning of drugs, which is characterized by the use of drugs already on the market for ...
Tópico(s): Bacterial biofilms and quorum sensing
2021 - Microbiology Society | Journal of Medical Microbiology
Produção Nacional
Revisado por pares
Letícia Serpa Sampaio Moreno, Hélio Vitoriano Nobre Júnior, Anderson Ramos da Silva, Francisca Bruna Stefany Aires do Nascimento, Cecília Rocha da Silva, João Batista de Andrade Neto, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Aurora Pinazo, Lourdes Pérez,
Tópico(s): Antifungal resistance and susceptibility
2021 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Produção Nacional
Revisado por pares
Chieko Yamagata, João Batista Freitas de Andrade, Valter Ussui, Nelson Batista de Lima, José Octavio Armani Paschoal,
Zircon sand was reacted with liquid caustic soda (50% NaOH) in open vessel at 600 oC for 2h. The effect of NaOH/ZrSiO4 reactant ratio on the yield of zirconia recovery was verified. Samples of fusion products water washed were characterized by X-ray diffraction (XRD) to identify the main compounds formed. Silica powders were obtained via acid catalyzed reaction and zirconia powders were resulted from crystallization of zirconium oxychoride. Both zirconia and silica powders were analyzed by XRF (X-ray ...
Tópico(s): Bone Tissue Engineering Materials
2008 - Trans Tech Publications | Materials science forum
Produção Nacional
Revisado por pares
Bruno C. Cavalcanti, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Antônio Adailson de Sousa Silva, Maria Erivanda França Rios, Francisco Stefânio Barreto, José Roberto de Oliveira Ferreira, Cecília Rocha da Silva, Fátima Daiana Dias Barroso, Hemerson Iury Ferreira Magalhães, Hélio Vitoriano Nobre Júnior, Manoel O. de Moraes,
No carcinogenesis or mutagenesis studies have been carried out with etomidate. The current study showed that etomidate has weak cytotoxic potential after 48 h exposure in human lymphocytes and has no hemolytic activity. The weak cytotoxicity seems to be related with redox imbalance of etomidate (40.9 and 81.9 μM) treated lymphocytes. At both etomidate concentrations, a slight decrease of the levels of GSH intracellular content and a significant increase in the amount of carbonylated proteins were ...
Tópico(s): bioluminescence and chemiluminescence research
2020 - Elsevier BV | Toxicology in Vitro
Produção Nacional
Revisado por pares
Maria AV Holanda, Cecília Rocha da Silva, João Batista de Andrade Neto, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Daiana D Barroso, Lisandra J da Silva, Thiago M Cândido, Amanda C Leitão, Amanda Dias Barbosa, Manoel Odorico de Moraes, Bruno Coelho Cavalcânti, Hélio Vitoriano Nobre Júnior,
Aim: The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical Candida spp. in planktonic and biofilm form. Materials & methods: The antifungal activity was observed using the broth microdilution technique. Flow cytometry tests were performed to investigate the probable mechanism of action and the comet test and cytotoxicity test were applied to evaluate DNA damage. Results: Midazolam (MIDAZ) showed antifungal ...
Tópico(s): Antifungal resistance and susceptibility
2021 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Yunierkis Pérez‐Castillo, Ricardo Carneiro Montes, Cecília Rocha da Silva, João Batista de Andrade Neto, Celidarque da Silva Dias, Allana Brunna Sucupira Duarte, Hélio Vitoriano Nobre Júnior, Damião Pergentino de Sousa,
Fungal infections remain a high-incidence worldwide health problem that is aggravated by limited therapeutic options and the emergence of drug-resistant strains. Cinnamic and benzoic acid amides have previously shown bioactivity against different species belonging to the Candida genus. Here, 20 cinnamic and benzoic acid amides were synthesized and tested for inhibition of C. krusei ATCC 14243 and C. parapsilosis ATCC 22019. Five compounds inhibited the Candida strains tested, with compound 16 (MIC = ...
Tópico(s): Computational Drug Discovery Methods
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
João Batista de Andrade, Wagner Lavezzo,
Foi realizado um ensaio para avaliar os efeitos da adicao de 0, 8, 16 e 24% de materia seca de rolao de milho, farelo de trigo e sacharina na forragem verde de Pennisetum purpureum Schum. cv. Guacu, no momento da ensilagem. O delineamento utilizado foi o de blocos ao acaso com parcelas subdivididas. Nas parcelas estudaram-se os aditivos e os niveis, e, nas subparcelas, os tipos de forragem (forragens + aditivos e suas silagens). A capineira foi fertilizada com 20 t/ha de esterco verde de curral e 80, ...
Tópico(s): Agroforestry and silvopastoral systems
1998 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Thiago M Cândido, Leilson C de Oliveira, Francisca Bruna Stefany Aires do Nascimento, Fátima DD Barroso, Lisandra J da Silva, Jacó RL de Mesquita, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Aim: The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. Materials & methods: The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used. Results: MRSA strains showed MIC equal to 500 and 1000 μg/ml of etomidate. Four-fifths (80%) of the tested MRSA strains demonstrated synergistic effect with oxacillin. ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2020 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
João Batista de Andrade, Evaldo Ferrari Júnior, Gilberto Braun,
O objetivo deste trabalho foi determinar o valor nutritivo de cana-de-açúcar tratada com 1,0% de hidróxido de sódio e acrescida de 0, 40, 80 e 120 kg de rolão-de-milho/t de cana-de-açúcar. O experimento foi conduzido no Instituto de Zootecnia, em Nova Odessa, SP, e o delineamento utilizado foi o de blocos ao acaso, com quatro repetições. O teste de consumo e digestibilidade foi efetuado com ovelhas em períodos de 10, 10 e 5 dias, que corresponderam, respectivamente, aos períodos de adaptação, controle ...
Tópico(s): Soil Management and Crop Yield
2001 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Maria Aparecida Alexandre Josino, Cecília Rocha da Silva, João Batista de Andrade Neto, Fátima Daiana Dias Barroso, Lisandra Juvêncio da Silva, Bruno C. Cavalcanti, Manoel Odorico de Moraes, Débora Hellen Almeida de Brito, Nágila Maria Pontes Silva Ricardo, Hélio Vitoriano Nobre Júnior,
The emergence of multidrug-resistant (MDR) bacteria is a global problem, by reducing the effectiveness of traditional antibiotics and decreasing the therapeutic arsenal to treat bacterial infections. This has led to an increase in researches about how to overcome this resistance to antibiotics. One strategy is the repositioning (or repurposing) of existing drugs not previously used to combat microorganisms, rather than the development of new drugs. Fluoxetine (FLX) is a selective serotonin reuptake ...
Tópico(s): Drug Solubulity and Delivery Systems
2020 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
Helaine Almeida Queiroz, Cecília Rocha da Silva, João Batista de Andrade Neto, Lívia Gurgel do Amaral Valente Sá, Francisca Bruna Stefany Aires do Nascimento, Letícia Serpa Sampaio Moreno, Fátima DD Barroso, Lisandra J da Silva, Thiago M Cândido, Leilson C de Oliveira, Jacó RL de Mesquita, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Hélio Vitoriano Nobre Júnior,
Aim: To evaluate the activity of diclofenac sodium and synergism with oxacillin against clinical strains of SARM in plactonic cells, antibiofilm and biofilm. Materials & methods: Synergism activity was assessed using the fractional inhibitory concentration index and its possible mechanism of action by flow cytometry. Results: The synergistic activity of diclofenac sodium with oxacillin was observed against plactonic cells, antibiofilm and in biofilm formed from clinical methicillin-resistant Staphylococcus ...
Tópico(s): Antimicrobial agents and applications
2021 - Future Medicine | Future Microbiology
Produção Nacional
Revisado por pares
Bruno C. Cavalcanti, João Batista de Andrade Neto, Antônio Adailson de Sousa Silva, Francisco Stefânio Barreto, José Roberto de Oliveira Ferreira, Cecília Rocha da Silva, Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, Hemerson Iury Ferreira Magalhães, Hélio Vitoriano Nobre Júnior, Manoel Odorico de Moraes,
Ketamine is a potent uncompetitive NMDA receptor antagonist that provides amnesia, analgesia, environmental dissociation and immobility, where it has its cytotoxic effect well described in the literature. However, the work on its genotoxic/mutagenic potentials are scarce and insufficient and does not allow a reasonable evaluation of its role. Thus, in the present work, we decided to evaluate the genotoxic and mutagenic effects of ketamine on human peripheral blood leukocytes (PBLs) and Salmonella ...
Tópico(s): Anesthesia and Sedative Agents
2019 - Elsevier BV | Toxicology in Vitro